Pub Date : 2024-07-01DOI: 10.21608/bvmj.2024.288019.1823
Heba Elsaied Sherif, Y. E. El- Senosi, S. Hussein, Ehab Mahmoud Elzoghaby, Mohamed Ahmed Sobh, Heba Sheta, Basma Hamed Osman
ABSTRACT
摘要
{"title":"Mesenchymal Stem Cells Restore Ovarian Function and Follicular Morphology Changes in Cyclophosphamide-Induced Infertility in Female Rats","authors":"Heba Elsaied Sherif, Y. E. El- Senosi, S. Hussein, Ehab Mahmoud Elzoghaby, Mohamed Ahmed Sobh, Heba Sheta, Basma Hamed Osman","doi":"10.21608/bvmj.2024.288019.1823","DOIUrl":"https://doi.org/10.21608/bvmj.2024.288019.1823","url":null,"abstract":"ABSTRACT","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.21608/bvmj.2024.282586.1805
Samia hamed Saliman, A. Edris, Mohamed Nabil
{"title":"Prevalence of Sulfite-reducing clostridia in some salted marketed fish products","authors":"Samia hamed Saliman, A. Edris, Mohamed Nabil","doi":"10.21608/bvmj.2024.282586.1805","DOIUrl":"https://doi.org/10.21608/bvmj.2024.282586.1805","url":null,"abstract":"","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-06DOI: 10.21608/bmfj.2023.230162.1877
Eman helal, reham gameaa
: Background: Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer worldwide. For individuals with intermediate-stage HCC, Transarterial chemoembolization (TACE) is a viable therapy option. So it is crucial to select patients to improve clinical outcomes in HCC patients after TACE. For patients with various cancers, immune health, including nutritional status and inflammatory state is essential. The prognostic nutritional index (PNI) is a multiparametric indicator that has been shown to accurately reflect patients' immune-inflammatory and nutritional status. The levels of neutrophil/lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been well-documented as systemic inflammation biomarkers that predict the prognosis of multiple neoplasms. Aim: This Study aimed to detect the impact of immuno-nutritional status in HCC patients treated with TACE. Patients and methods: Sixty patients with HCC who underwent TACE were enrolled and followed up in the Tropical Medicine Department, Tanta University. We excluded patients with prior locoregional therapy, systemic therapy and/or surgical intervention. At baseline and at 1& 3months post-procedure, laboratory criteria, tumor criteria were recorded, PNI, NLR PLR were calculated before TACE. Univariate and multivariate analyses were performed to identify factors affecting response to TACE. Results: Univariate analysis showed that high PNI, low NLR and low PLR were associated with a better response after TACE while multivariate analysis showed that only high PNI was an independent predictor of good response. Conclusion: Prognostic nutritional index can be used as baseline predictor of response before TACE.
{"title":"Impact of Immuno-nutritional status (prognostic nutritional index, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio) on response to Transarterial chemoembolization in Patients with Hepatocellular carcinoma","authors":"Eman helal, reham gameaa","doi":"10.21608/bmfj.2023.230162.1877","DOIUrl":"https://doi.org/10.21608/bmfj.2023.230162.1877","url":null,"abstract":": Background: Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer worldwide. For individuals with intermediate-stage HCC, Transarterial chemoembolization (TACE) is a viable therapy option. So it is crucial to select patients to improve clinical outcomes in HCC patients after TACE. For patients with various cancers, immune health, including nutritional status and inflammatory state is essential. The prognostic nutritional index (PNI) is a multiparametric indicator that has been shown to accurately reflect patients' immune-inflammatory and nutritional status. The levels of neutrophil/lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been well-documented as systemic inflammation biomarkers that predict the prognosis of multiple neoplasms. Aim: This Study aimed to detect the impact of immuno-nutritional status in HCC patients treated with TACE. Patients and methods: Sixty patients with HCC who underwent TACE were enrolled and followed up in the Tropical Medicine Department, Tanta University. We excluded patients with prior locoregional therapy, systemic therapy and/or surgical intervention. At baseline and at 1& 3months post-procedure, laboratory criteria, tumor criteria were recorded, PNI, NLR PLR were calculated before TACE. Univariate and multivariate analyses were performed to identify factors affecting response to TACE. Results: Univariate analysis showed that high PNI, low NLR and low PLR were associated with a better response after TACE while multivariate analysis showed that only high PNI was an independent predictor of good response. Conclusion: Prognostic nutritional index can be used as baseline predictor of response before TACE.","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135723671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : C MYC, BCL2 and CD30 play an important role in initiation and propagation of diffuse large B-cell lymphoma (DLBCL). Protein expression of these marker were used in the diagnosis, predicting the prognosis and as a therapeutic target in DLBCL. Purpose : This study aimed to assess the prognostic impact and therapeutic utility of expression patterns of CD30, BCL2, MYC in DLBCL. Patients and Methods: This retrospective study was carried out on DLBCL diagnosed at Oncology Centre Mansoura University (2016-2019). The study was approved by IRB of Mansoura faculty of Medicine Code Number: R.23.01.2043, 21/03/2023. Results : BCL2, C MYC, concurrent BCL2, C MYC and CD30 overexpression was present in 76%, 36%,and 26% of the studied cases respectively. Concurrent expressions of BCL2, C MYC showed significant association with the presence relapse (P= 0.003). Concurrent expression of BCL2, C MYC revealed significant association with the progressive therapy response (P=0.003). In addition, C MYC, expression was significantly associated with the presence of extra-nodal presentation (P=0.03). CD30 protein overexpression was significantly associated with stage II and III (P=0.03). CD30 positivity showed inverse correlation with the concurrent expression of BCL2, C MYC (Correlation Coefficient=--.355, P=0,02). Also, CD30 positivity and concurrent expression of BCL2, C MYC reflected significant prognostic impact on overall survival (OS) and disease free survival (DFS) (all P=0.00). Conclusion: concurrent C MYC, BCL2 overexpression is associated with a lower OS, and DFS. CD30 positivity is associated with a better OS, and DFS which can be utilized in management plan of DLBCL.
{"title":"Inverse correlation of concurrent BCL2, and C MYC expressions and CD30 positivity as regard the Prognostic significance in diffuse large B-cell lymphoma","authors":"afaf ibrahiem, Azza Abdel-aziz‎, Doaa Ghorab, shimaa yussif, Nahed Soliman","doi":"10.21608/bmfj.2023.213074.1829","DOIUrl":"https://doi.org/10.21608/bmfj.2023.213074.1829","url":null,"abstract":"Background : C MYC, BCL2 and CD30 play an important role in initiation and propagation of diffuse large B-cell lymphoma (DLBCL). Protein expression of these marker were used in the diagnosis, predicting the prognosis and as a therapeutic target in DLBCL. Purpose : This study aimed to assess the prognostic impact and therapeutic utility of expression patterns of CD30, BCL2, MYC in DLBCL. Patients and Methods: This retrospective study was carried out on DLBCL diagnosed at Oncology Centre Mansoura University (2016-2019). The study was approved by IRB of Mansoura faculty of Medicine Code Number: R.23.01.2043, 21/03/2023. Results : BCL2, C MYC, concurrent BCL2, C MYC and CD30 overexpression was present in 76%, 36%,and 26% of the studied cases respectively. Concurrent expressions of BCL2, C MYC showed significant association with the presence relapse (P= 0.003). Concurrent expression of BCL2, C MYC revealed significant association with the progressive therapy response (P=0.003). In addition, C MYC, expression was significantly associated with the presence of extra-nodal presentation (P=0.03). CD30 protein overexpression was significantly associated with stage II and III (P=0.03). CD30 positivity showed inverse correlation with the concurrent expression of BCL2, C MYC (Correlation Coefficient=--.355, P=0,02). Also, CD30 positivity and concurrent expression of BCL2, C MYC reflected significant prognostic impact on overall survival (OS) and disease free survival (DFS) (all P=0.00). Conclusion: concurrent C MYC, BCL2 overexpression is associated with a lower OS, and DFS. CD30 positivity is associated with a better OS, and DFS which can be utilized in management plan of DLBCL.","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135062671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.21608/bmfj.2023.160201.1657
Reda Sanad, Ahmad Sobeih, Ahmed Ibrahim, Hamada Khater
{"title":"Lung Ultrasonography in Evaluation of Neonatal Respiratory Distress","authors":"Reda Sanad, Ahmad Sobeih, Ahmed Ibrahim, Hamada Khater","doi":"10.21608/bmfj.2023.160201.1657","DOIUrl":"https://doi.org/10.21608/bmfj.2023.160201.1657","url":null,"abstract":"","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136133427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-28DOI: 10.21608/bmfj.2023.237606.1905
Enas Ahmad, Howyda Shabaan, Doaa Amin, Dina Abdelmotaleb
: Background: YKL-40, a glycoprotein, is associated with inflammatory conditions, including endothelial dysfunction and atherosclerosis. This study aimed to assess the significance of YKL-40 levels in the serum in a hemodialysis (HD) population and investigate their connection to cardiovascular disease (CVD) development. Methods: A case-control study was conducted from August 2022 to January 2023, involving 80 participants (30 patients with CVD and chronic HD, 30 patients with chronic HD without CVD, and 20 apparently healthy individuals). Laboratory assessments encompassed kidney function tests (creatinine and urea), serum sodium and potassium levels, Troponin I, highly sensitive C-reactive protein (Hs-CRP), and serum YKL-40 concentrations measured using ELISA. Incidences of CVD events among the patients were documented. Results: Significantly elevated YKL-40 levels were observed in HD patients with CVD compared to HD patients without CVD and the control group (p<0.001). There was also a significant increase in YKL-40 in HD patients without CVD compared to the control group (p<0.001). Additionally, a significant positive correlation was found between YKL-40 and Troponin I (p<0.001) in HD patients, both with and without CVD. ROC analysis indicated that YKL-40, with a cutoff value of >928.4 ng/ml, could effectively differentiate between HD patients with and without CVD. Both univariate and multivariate analyses demonstrated that troponin I and YKL-40 were associated with an increased likelihood of CVD among HD patients. Conclusion: YKL-40 is a biomarker associated with inflammation, and it is shown to have elevated levels among patients with HD. Among those patients, our study shows that YKL-40
{"title":"Association between YKL-40 and Cardiovascular Events in Hemodialysis Patients","authors":"Enas Ahmad, Howyda Shabaan, Doaa Amin, Dina Abdelmotaleb","doi":"10.21608/bmfj.2023.237606.1905","DOIUrl":"https://doi.org/10.21608/bmfj.2023.237606.1905","url":null,"abstract":": Background: YKL-40, a glycoprotein, is associated with inflammatory conditions, including endothelial dysfunction and atherosclerosis. This study aimed to assess the significance of YKL-40 levels in the serum in a hemodialysis (HD) population and investigate their connection to cardiovascular disease (CVD) development. Methods: A case-control study was conducted from August 2022 to January 2023, involving 80 participants (30 patients with CVD and chronic HD, 30 patients with chronic HD without CVD, and 20 apparently healthy individuals). Laboratory assessments encompassed kidney function tests (creatinine and urea), serum sodium and potassium levels, Troponin I, highly sensitive C-reactive protein (Hs-CRP), and serum YKL-40 concentrations measured using ELISA. Incidences of CVD events among the patients were documented. Results: Significantly elevated YKL-40 levels were observed in HD patients with CVD compared to HD patients without CVD and the control group (p<0.001). There was also a significant increase in YKL-40 in HD patients without CVD compared to the control group (p<0.001). Additionally, a significant positive correlation was found between YKL-40 and Troponin I (p<0.001) in HD patients, both with and without CVD. ROC analysis indicated that YKL-40, with a cutoff value of >928.4 ng/ml, could effectively differentiate between HD patients with and without CVD. Both univariate and multivariate analyses demonstrated that troponin I and YKL-40 were associated with an increased likelihood of CVD among HD patients. Conclusion: YKL-40 is a biomarker associated with inflammation, and it is shown to have elevated levels among patients with HD. Among those patients, our study shows that YKL-40","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-28DOI: 10.21608/bmfj.2023.228490.1875
Heba Rashad, Aya Abdel monem, Mohebat Gouda, Taghreed Abdelaziz
: Background: Adrenocortical tumors (ACTs) are detected in 5– 7% of the general population. Dysregulation of micro-ribonucleic acid (microRNA) biogenesis machinery-is involved in a variety of human cancers. Dicer1 is an essential component of microRNA machinery. Aim: To evaluate the diagnostic and prognostic significance of Dicer1 in adrenocortical adenoma (ACA) and carcinoma (ACC), then correlate the results with clinico-pathological data. Material and Methods: Forty adrenocortical lesions were included in this retrospective study, included (20) ACA and (20) ACC. Clinicopathological characteristics of examined cases were correlated with the IHC expression of Dicer1. Results: Dicer1 IHC expression was more frequent in ACC (65%) than in ACA (25%), (P =0.04). But among ACC, a weak Dicer1 expression was significantly more frequent in advanced ACCs. There was a significant statistical inverse relation between Dicer1 expression in studied ACC cases according to tumor size, weight, Weiss score, lymph node metastasis, lympho-vascular invasion and ENSAT stage (P <0.05). Other clinico-pathological variables such as age, sex, tumor site, tumor grade, and distant metastasis showed no significant statistical difference (P >0.05). Dicer1 showed 76% sensitivity and 67% specificity for differentiating ACA from ACC. Conclusion: Reduced Dicer1 expression with tumor progression in ACC may play a role in the tumorigenesis and further decline in Dicer1 expression may be associated with poor prognosis in ACC.
{"title":"Significance of Dicer1 in Adrenocortical Adenoma and Carcinoma (Immunohistochemical Study)","authors":"Heba Rashad, Aya Abdel monem, Mohebat Gouda, Taghreed Abdelaziz","doi":"10.21608/bmfj.2023.228490.1875","DOIUrl":"https://doi.org/10.21608/bmfj.2023.228490.1875","url":null,"abstract":": Background: Adrenocortical tumors (ACTs) are detected in 5– 7% of the general population. Dysregulation of micro-ribonucleic acid (microRNA) biogenesis machinery-is involved in a variety of human cancers. Dicer1 is an essential component of microRNA machinery. Aim: To evaluate the diagnostic and prognostic significance of Dicer1 in adrenocortical adenoma (ACA) and carcinoma (ACC), then correlate the results with clinico-pathological data. Material and Methods: Forty adrenocortical lesions were included in this retrospective study, included (20) ACA and (20) ACC. Clinicopathological characteristics of examined cases were correlated with the IHC expression of Dicer1. Results: Dicer1 IHC expression was more frequent in ACC (65%) than in ACA (25%), (P =0.04). But among ACC, a weak Dicer1 expression was significantly more frequent in advanced ACCs. There was a significant statistical inverse relation between Dicer1 expression in studied ACC cases according to tumor size, weight, Weiss score, lymph node metastasis, lympho-vascular invasion and ENSAT stage (P <0.05). Other clinico-pathological variables such as age, sex, tumor site, tumor grade, and distant metastasis showed no significant statistical difference (P >0.05). Dicer1 showed 76% sensitivity and 67% specificity for differentiating ACA from ACC. Conclusion: Reduced Dicer1 expression with tumor progression in ACC may play a role in the tumorigenesis and further decline in Dicer1 expression may be associated with poor prognosis in ACC.","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-20DOI: 10.21608/bmfj.2023.225229.1862
Seham El Berry, Mona Safwat, Tamer Asser, Ahmed Mohamed
Background: Digital colposcopy is a novel diagnostic approach that offers enhanced visualization and documentation of cervical abnormalities compared to traditional colposcopy. The conventional methods for diagnosing cervical pathology, including Pap smear (cytology) and classic histopathological examination of excised cervix have been the standard techniques for decades. This study aimed to evaluate the usefulness and accuracy of digital colposcopy as a comparable tool to the conventional pap smear (cytology) and the classic histopathological examination. Methods: This cross-sectional study was carried out on 77 sexually active women, aged 20 to 65 years, presenting with chronic leucorrhoea, post-coital bleeding/spotting, or intermenstrual bleeding/spotting. All participants underwent comprehensive assessments, including history taking, general and abdominal examinations and pelvic ultrasound. Pap smears were collected from the ectocervix and endocervix, while digital colposcopy utilizing equipment categorized colposcopic findings as "normal," "abnormal", or "miscellaneous". Digital colposcopy-directed biopsies were conducted for major findings or suspicious for invasion cases. Results : The digital colposcope demonstrated 76.9% sensitivity and a 72%specificity for detecting the condition according to histopathology. The PPV was 85.1%, and the NPV was 60%, resulting in an overall accuracy of 75.3%. On the other hand, the PAP smear exhibited higher performance with a sensitivity of 98.1% and a specificity of 84%. The PPV for the PAP smear was 92.7%, and the NPV was 95.5%, leading to an overall accuracy of 93.5%. Conclusion: Digital colposcopy holds promise as a valuable adjunct to conventional screening methods, such as the Pap smear, in diagnosing cervical pathology
{"title":"Accuracy of Digital Colposcopy in Diagnosis of Cervical Pathology","authors":"Seham El Berry, Mona Safwat, Tamer Asser, Ahmed Mohamed","doi":"10.21608/bmfj.2023.225229.1862","DOIUrl":"https://doi.org/10.21608/bmfj.2023.225229.1862","url":null,"abstract":"Background: Digital colposcopy is a novel diagnostic approach that offers enhanced visualization and documentation of cervical abnormalities compared to traditional colposcopy. The conventional methods for diagnosing cervical pathology, including Pap smear (cytology) and classic histopathological examination of excised cervix have been the standard techniques for decades. This study aimed to evaluate the usefulness and accuracy of digital colposcopy as a comparable tool to the conventional pap smear (cytology) and the classic histopathological examination. Methods: This cross-sectional study was carried out on 77 sexually active women, aged 20 to 65 years, presenting with chronic leucorrhoea, post-coital bleeding/spotting, or intermenstrual bleeding/spotting. All participants underwent comprehensive assessments, including history taking, general and abdominal examinations and pelvic ultrasound. Pap smears were collected from the ectocervix and endocervix, while digital colposcopy utilizing equipment categorized colposcopic findings as \"normal,\" \"abnormal\", or \"miscellaneous\". Digital colposcopy-directed biopsies were conducted for major findings or suspicious for invasion cases. Results : The digital colposcope demonstrated 76.9% sensitivity and a 72%specificity for detecting the condition according to histopathology. The PPV was 85.1%, and the NPV was 60%, resulting in an overall accuracy of 75.3%. On the other hand, the PAP smear exhibited higher performance with a sensitivity of 98.1% and a specificity of 84%. The PPV for the PAP smear was 92.7%, and the NPV was 95.5%, leading to an overall accuracy of 93.5%. Conclusion: Digital colposcopy holds promise as a valuable adjunct to conventional screening methods, such as the Pap smear, in diagnosing cervical pathology","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135665227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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