Astaxanthin is known to be a significant carotenoid recognized for its biomedicine and therapeutic applications offering strong immune support, antioxidant properties, and protective benefits to skin, cardiovascular system. This review discusses global market insights, ongoing challenges to cope up with and various biotechnological advancements aiming at enhancement of astaxanthin production biologically. Researchers are in process to refine cultivation conditions, optimization strategies, stress induction, and improving extraction protocol to raise overall output.This review more emphasizes on outcome-driven biotechnological approaches to optimize culture conditions for enhancing astaxanthin productivity. Additionally, AI-driven modeling platforms are emerging to serve mining of multi omics data and predicts optimal gene edits or culture parameters, accelerating the natural astaxanthin yields. Coupling high-throughput techniques like Next Generation Sequencing (NGS) with AI-driven data analysis making it possible to select the superior strains along with adjusting the growth conditions.A deeper grasp of the molecule’s biosynthetic regulation will also clarify its therapeutic promise against chronic illness. This review outlines the application of Life cycle Assessment (LCA) integrated with techno-economic analysis in evaluating the feasibility, and cost effectiveness of natural astaxanthin production, comparing conventional methods with innovative approaches enabled by genetic engineering.Future work on astaxanthin production should focus on integrating strain engineering, smart bioprocess design, and formulating sustainable assessment along with proper techno-economic analysis to overcome current limitation of biomass productivity.
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