Amr Farhan, A. Lyazidi, Badreddine Labakoum, M. Rattal, A. Mouhsen
Chronic stress overactivates the sympathetic nervous system, which alters the body, mind, and behavior. Purpose Stress can indeed be employed to preserve homeostasis when there is a physical or mental imbalance brought on by damaging stimuli. Currently, there isn't a standard reference point for quantifying stress. The purpose of this meta-analysis is to assess studies that support the use of heart rate variability (HRV) as an indicator of stress. Methods and Materials: Studies concerning HRV that have been published in bibliographic database from 2013 to 2023 were firstly selected. A total of 181 articles were found, 69 in Elsevier, 51 in Google Scholar, 38 PubMed, and 23 in other databases. The criteria selected were human study, HRV reactivity and the HRV as an objective indicator of psychological stress. Only human study was restrained. Finally, ten publications that fit criteria were found. Results: Majority of research selected found that HRV components changed in response to stress brought on by diverse techniques. The most often cited component associated with variance in HRV variables was a drop in the high-frequency band and an increase in the low-frequency band, both of which are markers of diminished parasympathetic activity. HRV may be related to cortical areas that are engaged in evaluating stressful situations, according to neuroimaging research. Conclusion: The findings support the use of HRV for the purpose of evaluating stress and mental health objectively, and neurobiological data suggests that HRV is impacted by stress reactions.
{"title":"Impact of Heart Rate Variability on Physiological Stress: Systematic Review","authors":"Amr Farhan, A. Lyazidi, Badreddine Labakoum, M. Rattal, A. Mouhsen","doi":"10.13005/bpj/2681","DOIUrl":"https://doi.org/10.13005/bpj/2681","url":null,"abstract":"Chronic stress overactivates the sympathetic nervous system, which alters the body, mind, and behavior. Purpose Stress can indeed be employed to preserve homeostasis when there is a physical or mental imbalance brought on by damaging stimuli. Currently, there isn't a standard reference point for quantifying stress. The purpose of this meta-analysis is to assess studies that support the use of heart rate variability (HRV) as an indicator of stress. Methods and Materials: Studies concerning HRV that have been published in bibliographic database from 2013 to 2023 were firstly selected. A total of 181 articles were found, 69 in Elsevier, 51 in Google Scholar, 38 PubMed, and 23 in other databases. The criteria selected were human study, HRV reactivity and the HRV as an objective indicator of psychological stress. Only human study was restrained. Finally, ten publications that fit criteria were found. Results: Majority of research selected found that HRV components changed in response to stress brought on by diverse techniques. The most often cited component associated with variance in HRV variables was a drop in the high-frequency band and an increase in the low-frequency band, both of which are markers of diminished parasympathetic activity. HRV may be related to cortical areas that are engaged in evaluating stressful situations, according to neuroimaging research. Conclusion: The findings support the use of HRV for the purpose of evaluating stress and mental health objectively, and neurobiological data suggests that HRV is impacted by stress reactions.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87985643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Romano, S. Mastrangelo, G. Attina’, P. Maurizi, A. Ruggiero
The diagnosis of pregnancy-associated cancer, although rare, is a condition of great human and social significance and difficult clinical management. A pregnancy-associated neoplasm is defined as a cancer diagnosis made during pregnancy or within 12 months after delivery/abortion. The most common cancers in pregnancy occur most frequently in women of reproductive age with an incidence overall like that observed in non-pregnant women of the same age. This incidence is likely to increase in view of both the expected increase in certain malignancies among young women (particularly breast cancer and melanoma) and the increasing frequency of pregnancies undertaken later in life (fourth and fifth decades of life) that is characterizing modern society. Chemotherapy is generally contraindicated before 12 weeks of pregnancy due to the increased risk of congenital anomalies while exposure in the second and third trimester of pregnancy to chemotherapy has been associated with more growth restriction and preterm delivery. Clinical decisions about the optimal management should consider maternal and fetal characteristics with the involvement of a multidisciplinary team.
{"title":"Pregnancy-associated Cancer and Chemotherapy during Pregnancy","authors":"A. Romano, S. Mastrangelo, G. Attina’, P. Maurizi, A. Ruggiero","doi":"10.13005/bpj/2652","DOIUrl":"https://doi.org/10.13005/bpj/2652","url":null,"abstract":"The diagnosis of pregnancy-associated cancer, although rare, is a condition of great human and social significance and difficult clinical management. A pregnancy-associated neoplasm is defined as a cancer diagnosis made during pregnancy or within 12 months after delivery/abortion. The most common cancers in pregnancy occur most frequently in women of reproductive age with an incidence overall like that observed in non-pregnant women of the same age. This incidence is likely to increase in view of both the expected increase in certain malignancies among young women (particularly breast cancer and melanoma) and the increasing frequency of pregnancies undertaken later in life (fourth and fifth decades of life) that is characterizing modern society. Chemotherapy is generally contraindicated before 12 weeks of pregnancy due to the increased risk of congenital anomalies while exposure in the second and third trimester of pregnancy to chemotherapy has been associated with more growth restriction and preterm delivery. Clinical decisions about the optimal management should consider maternal and fetal characteristics with the involvement of a multidisciplinary team.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87408131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study was designed to investigate effect of artesunate on blood parameters in female rats. Ten female Wistar rats (130 – 150 g) were grouped into control and artesunate (1.43 mg/kg) – treated groups for blood assay. The artesunate was administered orally for 50 days. Hematological assay was carried out using hemocytometer, while biochemical assay was carried out using spectrophotometry. Mean +/- SEM and student’s t-test at p<0.05 were determined. Artesunate (1.43 mg/kg) significantly reduced RBC, platelet and lymphocyte counts when compared to their controls. It also significantly decreased total protein, ALT and ALP values relative to their controls. However, it induced no significant changes in the PCV, Hb, TWBC, neutrophil, monocyte, eosinophil, MCV, MCHC, MCH, albumin, globulin, AST, BUN and creatinine values relative to their controls. Conclusively, it can be suggested that artesunate had both harmful and advantageous effects on blood parameters in female rats.
{"title":"Effect of Artesunate on Haematological and Plasma Biochemical Parameters in Female Wistar Rats","authors":"Oyedeji K. O, Abiodun A","doi":"10.13005/bpj/2706","DOIUrl":"https://doi.org/10.13005/bpj/2706","url":null,"abstract":"This study was designed to investigate effect of artesunate on blood parameters in female rats. Ten female Wistar rats (130 – 150 g) were grouped into control and artesunate (1.43 mg/kg) – treated groups for blood assay. The artesunate was administered orally for 50 days. Hematological assay was carried out using hemocytometer, while biochemical assay was carried out using spectrophotometry. Mean +/- SEM and student’s t-test at p<0.05 were determined. Artesunate (1.43 mg/kg) significantly reduced RBC, platelet and lymphocyte counts when compared to their controls. It also significantly decreased total protein, ALT and ALP values relative to their controls. However, it induced no significant changes in the PCV, Hb, TWBC, neutrophil, monocyte, eosinophil, MCV, MCHC, MCH, albumin, globulin, AST, BUN and creatinine values relative to their controls. Conclusively, it can be suggested that artesunate had both harmful and advantageous effects on blood parameters in female rats.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88684873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
With the emerging trend of preferring naturopathy over modern medicine, common people are in more danger when consuming natural plant products without the knowledge of the toxic agents present in them. Aim and Objective: To evaluate the safety of methanolic leaf extract of Costus pictus D Don on albino Wistar rats. Methodology: The current study was designed strictly based on the organization for economic cooperation and development (OECD) guideline 423 for acute toxicity study to determine LD50 and guideline 407 for sub-acute toxicity study for hazard identification and risk assessment of the test solution. Methanolic leaf extract was prepared by soxhlation. 12 animals (each 12-week-old nulliparous, non-pregnant female Wistar rats with a mean weight of 142 ± 2 g), 3 per step were used for the acute toxicity study. The test was initiated with a single test dose of 300 mg/kg BW on three animals and continued till 2000 mg/kg BW. After ingesting the test dose each animal was observed individually for the first 4 hours and later every day for 2 weeks for signs of toxicity. For the sub-acute toxicity study, 30 adult Wistar rats (each 16-week-old rat weighing 250±12g) were randomized into 3 groups (1 control and 2 study groups) of 10 each consisting of five males and 5 females. Animals in the control group received 1% Carboxymethyl cellulose (CMC) at a dose of 10 ml/kg BW whereas the animals in the study group received 500 and 1000 mg/kg body weight (BW) of the extract respectively for 28 days. Later, all the animals were sacrificed and blood samples were studied for hematological and biochemical changes. Results: The lethal dose of Costus pictus D Don methanolic leaf extract was fixed as more than 2000 mg/kg Body weight. No obvious change was observed in feeding habits, weight, hematology, biochemical parameters, and histopathology. Conclusion: Methanolic leaf extract of Costus pictus D Don was observed to be absolutely safe when given orally in albino Wistar rats.
{"title":"Evaluation of Safety Profile of Costus Pictus D Don Methanolic Leaf Extract on Albino Wistar Rats","authors":"J. Raj, P. S, M. K, Srinivasan Ar","doi":"10.13005/bpj/2673","DOIUrl":"https://doi.org/10.13005/bpj/2673","url":null,"abstract":"With the emerging trend of preferring naturopathy over modern medicine, common people are in more danger when consuming natural plant products without the knowledge of the toxic agents present in them. Aim and Objective: To evaluate the safety of methanolic leaf extract of Costus pictus D Don on albino Wistar rats. Methodology: The current study was designed strictly based on the organization for economic cooperation and development (OECD) guideline 423 for acute toxicity study to determine LD50 and guideline 407 for sub-acute toxicity study for hazard identification and risk assessment of the test solution. Methanolic leaf extract was prepared by soxhlation. 12 animals (each 12-week-old nulliparous, non-pregnant female Wistar rats with a mean weight of 142 ± 2 g), 3 per step were used for the acute toxicity study. The test was initiated with a single test dose of 300 mg/kg BW on three animals and continued till 2000 mg/kg BW. After ingesting the test dose each animal was observed individually for the first 4 hours and later every day for 2 weeks for signs of toxicity. For the sub-acute toxicity study, 30 adult Wistar rats (each 16-week-old rat weighing 250±12g) were randomized into 3 groups (1 control and 2 study groups) of 10 each consisting of five males and 5 females. Animals in the control group received 1% Carboxymethyl cellulose (CMC) at a dose of 10 ml/kg BW whereas the animals in the study group received 500 and 1000 mg/kg body weight (BW) of the extract respectively for 28 days. Later, all the animals were sacrificed and blood samples were studied for hematological and biochemical changes. Results: The lethal dose of Costus pictus D Don methanolic leaf extract was fixed as more than 2000 mg/kg Body weight. No obvious change was observed in feeding habits, weight, hematology, biochemical parameters, and histopathology. Conclusion: Methanolic leaf extract of Costus pictus D Don was observed to be absolutely safe when given orally in albino Wistar rats.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79697836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: It is a widely held belief that if the trigeminal nerve is damaged, the victim would experience agonising and unrelenting external pain. A lesion to the trigeminal nerve may have a wide-reaching effect, such as on one side of the face in particular, or it might have a more localised effect, such as on some or all of your gums. The risk of damage increases the likelihood that it will be difficult to speak and swallow. This nerve provides sensation to a part of your face that may be constantly aching or tingling for some people. However, the trigeminal nerve injury-related persistent orofacial pain might be brought on by a wide variety of unknown triggers. Aim: In this study investigate the clinical manifestations of chronic orofacial pain brought on by a damage to the trigeminal nerve, as well as the diagnostic and therapeutic approaches available to treat this condition. Methodology Through the use of search phrases such as "Trigeminal nerve injury," "Trigeminal ganglion," "Trigeminal spinal subnucleus caudalis," "Craniofacial pain," "Oral prognosis," and "treatment," the computerised databases for the last twenty years have been investigated. There are now two hundred objects in total that have been accumulated. There have been around fifty of them that are pertinent to the discussion that is going on in this work. Majority of the patients fair enough with the pharmacology treatment/drugs like the carbamazepine & oxcarbazepine which forms the first line treatment options followed by lamotrigine & baclofen encompassing the second line of drugs along with adjuvant drug support of topiramate, levetiracetam, gabapentin, pregabalin. As the field of science has explored &advanced for the latest treatment options include microvascular decompression, gamma knife radiosurgery, percutaneous rhizotomies variable based on the evidences & guidelines 54 Conclusion: New diagnostic criteria and treatment alternatives have become available for people who suffer from trigeminal neuropathy and orofacial neuropathic pain as a result of recent developments in fundamental animal research that have led to their development. Despite the results, more research needs to investigate a greater variety of distinct non-neuronal cell feature approaches.
{"title":"Pathophysiology, Clinical Implications and Management of Orofacial Neuropathic Pain- with special attention to Trigeminal neuralgia: A Narrative Review","authors":"A. Nabhan","doi":"10.13005/bpj/2666","DOIUrl":"https://doi.org/10.13005/bpj/2666","url":null,"abstract":"Background: It is a widely held belief that if the trigeminal nerve is damaged, the victim would experience agonising and unrelenting external pain. A lesion to the trigeminal nerve may have a wide-reaching effect, such as on one side of the face in particular, or it might have a more localised effect, such as on some or all of your gums. The risk of damage increases the likelihood that it will be difficult to speak and swallow. This nerve provides sensation to a part of your face that may be constantly aching or tingling for some people. However, the trigeminal nerve injury-related persistent orofacial pain might be brought on by a wide variety of unknown triggers. Aim: In this study investigate the clinical manifestations of chronic orofacial pain brought on by a damage to the trigeminal nerve, as well as the diagnostic and therapeutic approaches available to treat this condition. Methodology Through the use of search phrases such as \"Trigeminal nerve injury,\" \"Trigeminal ganglion,\" \"Trigeminal spinal subnucleus caudalis,\" \"Craniofacial pain,\" \"Oral prognosis,\" and \"treatment,\" the computerised databases for the last twenty years have been investigated. There are now two hundred objects in total that have been accumulated. There have been around fifty of them that are pertinent to the discussion that is going on in this work. Majority of the patients fair enough with the pharmacology treatment/drugs like the carbamazepine & oxcarbazepine which forms the first line treatment options followed by lamotrigine & baclofen encompassing the second line of drugs along with adjuvant drug support of topiramate, levetiracetam, gabapentin, pregabalin. As the field of science has explored &advanced for the latest treatment options include microvascular decompression, gamma knife radiosurgery, percutaneous rhizotomies variable based on the evidences & guidelines 54 Conclusion: New diagnostic criteria and treatment alternatives have become available for people who suffer from trigeminal neuropathy and orofacial neuropathic pain as a result of recent developments in fundamental animal research that have led to their development. Despite the results, more research needs to investigate a greater variety of distinct non-neuronal cell feature approaches.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88310599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ginseng is a plant’s root of the Panax family that is characterized by the presence of ginsenosides. It is used as a traditional medicine for many years in East Asian regions generally as an adaptogenic medicine to make the body resistant to homeostasis and other adverse environmental factors. Inflammation and lipid signaling are intermixed modulators of homeostasis and immunity. Cyclooxygenase is a key enzyme in lipid signalling. The present study focused on the anti-inflammatory analysis of phytoconstituents of the ginseng plant against COX1 and COX2 genes. In this study we approached the study of the interaction of phytoconstituents of ginseng plant with COX-1 and COX-2 using an insilico approach. It is done in 2 main stages: docking between COX1 and COX2 with phytoconstituents of ginseng plant and the ADMET analysis. . The drug-likeness of phytoconstituents were predicted and the ADMET properties. Molecular docking studies were done using the Autodock server and MyPresto program to explore the binding pattern with COX-1 and COX-2. The result showed that phytoconstituents gallic acid and myricetin have high anti-inflammatory action due to the electrostatic force of attraction of COX1 and COX2. Quercetin, and apigenin due to high binding affinity due to the attraction of COX2, epicatechin, and chlorogenic acid on COX1. The phytoconstituents gallic acid, myricetin, apigenin, chlorogenic acid, epicatechin and quercetin can potentially be used as anti-inflammatory agents.
{"title":"Anti-Inflammatory Activity of Phytoconstituents of Ginseng Plant- Insilico Approach","authors":"Anit Treesa Joy, H. M, Rishad K. S","doi":"10.13005/bpj/2698","DOIUrl":"https://doi.org/10.13005/bpj/2698","url":null,"abstract":"Ginseng is a plant’s root of the Panax family that is characterized by the presence of ginsenosides. It is used as a traditional medicine for many years in East Asian regions generally as an adaptogenic medicine to make the body resistant to homeostasis and other adverse environmental factors. Inflammation and lipid signaling are intermixed modulators of homeostasis and immunity. Cyclooxygenase is a key enzyme in lipid signalling. The present study focused on the anti-inflammatory analysis of phytoconstituents of the ginseng plant against COX1 and COX2 genes. In this study we approached the study of the interaction of phytoconstituents of ginseng plant with COX-1 and COX-2 using an insilico approach. It is done in 2 main stages: docking between COX1 and COX2 with phytoconstituents of ginseng plant and the ADMET analysis. . The drug-likeness of phytoconstituents were predicted and the ADMET properties. Molecular docking studies were done using the Autodock server and MyPresto program to explore the binding pattern with COX-1 and COX-2. The result showed that phytoconstituents gallic acid and myricetin have high anti-inflammatory action due to the electrostatic force of attraction of COX1 and COX2. Quercetin, and apigenin due to high binding affinity due to the attraction of COX2, epicatechin, and chlorogenic acid on COX1. The phytoconstituents gallic acid, myricetin, apigenin, chlorogenic acid, epicatechin and quercetin can potentially be used as anti-inflammatory agents.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75413363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Masyeni, I. Made, Wisnu Wardhana, H. Harapan, A. Santosa, E. Nelwan
Background: Vaccination has been recognized as an additional option, besides the health protocols practices to control the coronavirus disease 2019 (COVID-19) pandemic, especially with the unknown specific treatment for the disease. This study sought to evaluate the immunogenicity of CoronaVac among the general population in Bali province, a popular tourist spot in Indonesia. Methods: As many as 422 volunteers were recruited from the three vaccination centers, of which 230 volunteers were seronegative and included in the study. CoronaVac was used as vaccine with dose of 0.5 mL or 3 µg at each administration. Blood samples were drawn before vaccination, 21 days after the first dose, and 56 days after second dose, where the interval between the first and second dose vaccination was 28 days. Vaccine immunogenicity was evaluated by the anti-spike receptor-binding domain (anti-S-RBD) IgG titer which was measured using the electrochemiluminescence immunoassay technique. Results: The mean anti-S-RBD levels at 21 days after first dose, and 21 days after the second dose of vaccination are 25.25 ± 59.74 U/mL and 138.77 ± 90.93 U/mL, respectively. The result of the Friedman test was p <0.001 which means that there are significant differences in anti-S-RBD levels between 21 days after first dose and 21 days after second vaccination. Post hoc analysis with the Wilcoxon test also showed significant difference among the three-testing point (p < 0.001). The seroconversion rate from the first dose of CoronaVac was 69.7% and it increased to 99.4% (171/172) on after the second dose. Conclusion: Although the protective level was not totally reached on the first vaccination, the immunogenicity was considered rapid 3 weeks after the first vaccination.
{"title":"S-RBD Antibody Titers Following the First and Second Doses of Inactivated SARS-CoV-2 Vaccination (CoronaVac) in Native Participants: A Prospective Cohort Study in Bali, Indonesia","authors":"S. Masyeni, I. Made, Wisnu Wardhana, H. Harapan, A. Santosa, E. Nelwan","doi":"10.13005/bpj/2654","DOIUrl":"https://doi.org/10.13005/bpj/2654","url":null,"abstract":"Background: Vaccination has been recognized as an additional option, besides the health protocols practices to control the coronavirus disease 2019 (COVID-19) pandemic, especially with the unknown specific treatment for the disease. This study sought to evaluate the immunogenicity of CoronaVac among the general population in Bali province, a popular tourist spot in Indonesia. Methods: As many as 422 volunteers were recruited from the three vaccination centers, of which 230 volunteers were seronegative and included in the study. CoronaVac was used as vaccine with dose of 0.5 mL or 3 µg at each administration. Blood samples were drawn before vaccination, 21 days after the first dose, and 56 days after second dose, where the interval between the first and second dose vaccination was 28 days. Vaccine immunogenicity was evaluated by the anti-spike receptor-binding domain (anti-S-RBD) IgG titer which was measured using the electrochemiluminescence immunoassay technique. Results: The mean anti-S-RBD levels at 21 days after first dose, and 21 days after the second dose of vaccination are 25.25 ± 59.74 U/mL and 138.77 ± 90.93 U/mL, respectively. The result of the Friedman test was p <0.001 which means that there are significant differences in anti-S-RBD levels between 21 days after first dose and 21 days after second vaccination. Post hoc analysis with the Wilcoxon test also showed significant difference among the three-testing point (p < 0.001). The seroconversion rate from the first dose of CoronaVac was 69.7% and it increased to 99.4% (171/172) on after the second dose. Conclusion: Although the protective level was not totally reached on the first vaccination, the immunogenicity was considered rapid 3 weeks after the first vaccination.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72770332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arshia Singh, Amit Gupta, Simran Srivastava, Bhavya Choudhury, Sidharth Jain, A. Bajpai
Natural products are believed to be one of the richest sources of prophylactic and therapeutic-based compounds which show a wide range of applications in the food and pharmaceutical industries. An aqueous extract of Momordica charantia was evaluated systematically for antioxidant (2,2-diphenyl-1-picrylhydrazyl, DPPH free radical assay), antimicrobial (bacterial strains), and anti-inflammatory (heat-induced hemolysis, proteinase inhibitory activity, protein denaturation, i.e., bovine serum albumin, BSA, and typhoid vaccine) agents, as well as its phenolic content. The results showed its higher concentration of phenolic content, as reported in this study, which is directly correlated with the antioxidant activity of Momordica charantia against DPPH. Similar results were obtained in the antimicrobial assay, where the diameter of the inhibition zone against bacterial strains is measured in millimetres (mm), which is wider in the case of the aqueous extract. In addition, anti-inflammatory studies were also taken into consideration, and the results suggest that higher doses of Momordica charantia may enhanced the percentage of protein denaturation as compared to BSA or typhoid vaccine alone and also induced heat induce hemolysis and proteinase inhibitory activity, In short, Momordica charantia may have shown several immunopharmacological properties, and this study may have been used further have used for isolation of desired prophylactic or therapeutic based compounds and to develop better nutraceutical or pharmaceutical agents.
{"title":"Assessment its Antioxidant, Antimicrobial and Anti-Inflammatory Potential of Momordica Charantia","authors":"Arshia Singh, Amit Gupta, Simran Srivastava, Bhavya Choudhury, Sidharth Jain, A. Bajpai","doi":"10.13005/bpj/2672","DOIUrl":"https://doi.org/10.13005/bpj/2672","url":null,"abstract":"Natural products are believed to be one of the richest sources of prophylactic and therapeutic-based compounds which show a wide range of applications in the food and pharmaceutical industries. An aqueous extract of Momordica charantia was evaluated systematically for antioxidant (2,2-diphenyl-1-picrylhydrazyl, DPPH free radical assay), antimicrobial (bacterial strains), and anti-inflammatory (heat-induced hemolysis, proteinase inhibitory activity, protein denaturation, i.e., bovine serum albumin, BSA, and typhoid vaccine) agents, as well as its phenolic content. The results showed its higher concentration of phenolic content, as reported in this study, which is directly correlated with the antioxidant activity of Momordica charantia against DPPH. Similar results were obtained in the antimicrobial assay, where the diameter of the inhibition zone against bacterial strains is measured in millimetres (mm), which is wider in the case of the aqueous extract. In addition, anti-inflammatory studies were also taken into consideration, and the results suggest that higher doses of Momordica charantia may enhanced the percentage of protein denaturation as compared to BSA or typhoid vaccine alone and also induced heat induce hemolysis and proteinase inhibitory activity, In short, Momordica charantia may have shown several immunopharmacological properties, and this study may have been used further have used for isolation of desired prophylactic or therapeutic based compounds and to develop better nutraceutical or pharmaceutical agents.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80326997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Afnan Nurul Aman Shaikh, Khadija Jalal, Athira Suresh Kumar, Swetha Kannan, J. Muttappallymyalil
Background: Patients throughout the world frequently use complementary and alternative medicine (CAM), especially to treat chronic or untreatable diseases. Since the standards for many chronic illnesses have shifted dramatically, researches have shown that many healthcare providers include integrative and holistic approach in their treatment programs. Therefore, this study evaluates people's literacy, attitudes, and usage of CAM modalities in the current setting. Methods: The thorough narrative review presented is carried out utilizing six computerized databases: Taylor & Francis Online, Research Gate, Frontiers, ScienceDirect, BioMed Central, and PubMed. The key word used for the search was Complementary and alternate medicine (CAM). The results were collected and subjected to content analysis. Results: The current data show that people who are employed, younger, and female likely to be more knowledgeable, have better attitudes, and use CAM frequently. Friends and family are the most frequent sources of knowledge about CAM. Conclusion: Further study is needed in this area due to the lack of studies that address CAM literacy and attitudes.
背景:世界各地的患者经常使用补充和替代医学(CAM)，特别是治疗慢性或不治之症。由于许多慢性疾病的标准发生了巨大的变化，研究表明，许多医疗保健提供者在他们的治疗方案中包括综合和整体的方法。因此，本研究评估人们的读写能力，态度，和使用CAM模式在当前的设置。方法:采用六个计算机化数据库:Taylor & Francis Online、Research Gate、Frontiers、ScienceDirect、BioMed Central和PubMed进行全面的叙述性综述。搜索的关键词是补充替代医学(CAM)。收集结果并进行内容分析。结果:目前的数据显示，有工作的人，年轻的，女性可能更有知识，有更好的态度，并经常使用CAM。朋友和家人是了解CAM最常见的来源。结论:由于缺乏关于CAM素养和态度的研究，这一领域需要进一步研究。
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Akshatha P Kamath, N. Patil, Amrita Parida, Karthik Rao, Nadeem Khan G, S. Gurung, Afreen Begum H Itagi, M. V, Heraa Islam, Mohsin Nazeer, S. Hegde, N. Anand
In the present study, reproductive toxicity caused by cyclophosphamide on sperm parameters, biochemical parameters, histopathology and protective effect of wheatgrass juice was examined. There were total 6 groups of adult Wistar albino rats. Each group had 6 rats. After 24hrs of the last treatment, rats were sacrificed by cervical dislocation and sperm parameters like sperm count and motility, plasma malonaldehyde (MDA) levels, catalase (CAT) levels, superoxide dismutase (SOD) and glutathione (GSH) activities in testicular tissue, and testicular histopathological changes in the testicular tissue were examined. Administration of cyclophosphamide showed an increase in plasma MDA level and decrease in SOD, GSH and Catalase activity. These values were statistically significant. However, wheatgrass juice treatment along with cyclophosphamide markedly showed improvement in reducing Cyclophosphamide-induced oxidative stress, and normalized sperm characteristics and testicular histopathology. Thus, in conclusion, cyclophosphamide causes fertility changes which leads to male infertility, whereas wheatgrass juice has a protective effect on reversing the testicular damage and male infertility.
{"title":"Effect of Wheatgrass Juice on Fertility Changes Induced by Cyclophosphamide in Male Wistar Albino Rats","authors":"Akshatha P Kamath, N. Patil, Amrita Parida, Karthik Rao, Nadeem Khan G, S. Gurung, Afreen Begum H Itagi, M. V, Heraa Islam, Mohsin Nazeer, S. Hegde, N. Anand","doi":"10.13005/bpj/2682","DOIUrl":"https://doi.org/10.13005/bpj/2682","url":null,"abstract":"In the present study, reproductive toxicity caused by cyclophosphamide on sperm parameters, biochemical parameters, histopathology and protective effect of wheatgrass juice was examined. There were total 6 groups of adult Wistar albino rats. Each group had 6 rats. After 24hrs of the last treatment, rats were sacrificed by cervical dislocation and sperm parameters like sperm count and motility, plasma malonaldehyde (MDA) levels, catalase (CAT) levels, superoxide dismutase (SOD) and glutathione (GSH) activities in testicular tissue, and testicular histopathological changes in the testicular tissue were examined. Administration of cyclophosphamide showed an increase in plasma MDA level and decrease in SOD, GSH and Catalase activity. These values were statistically significant. However, wheatgrass juice treatment along with cyclophosphamide markedly showed improvement in reducing Cyclophosphamide-induced oxidative stress, and normalized sperm characteristics and testicular histopathology. Thus, in conclusion, cyclophosphamide causes fertility changes which leads to male infertility, whereas wheatgrass juice has a protective effect on reversing the testicular damage and male infertility.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84618432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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