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PROBIOTICS AND PREBIOTICS 益生元
Pub Date : 2018-09-15 DOI: 10.1159/isbn.978-3-318-03059-4
Urvashi B Singh, Rizwan M. Sanadi
The human gut contains 10 times more bacteria than cells elsewhere in human body. The enormous biomass consists of over 400 known bacterial species that generate intense metabolic activity and are of key importance for human health. Resident microbiota actively contributes to host protection through: blocking of colonization by pathogens, development of cell structure and function, development of the immune system and modulation of inflammatory responses, commensal bacteria influence expression of mediators such as intracellular adhesion molecule I (ICAM-I), E-selectin, and Interleukin (IL-8), commensal bacteria also modulate immune responses and enhance cellular homeostatic mechanisms. 1 This ecosystem gets disrupted when exposed to toxic substances in the form of polluted water and food as well as injudicious use of antibiotics. Antibiotic resistance, with the emergence of multiple resistant strains, is an increasingly important global problem. This causes destruction of beneficial bacteria leaving behind  resistant, pathogenic bacteria. 1   With the number of bacteria-resistant diseases on the rise and the length of time it takes to develop new antibiotics, it might be time to consider another alternative, for eg. the use of beneficial bacteria, the  'Probiotics', which stimulate health promoting indigenous flora and reverting back the change,  in the treatment of periodontal disease.
人体肠道中细菌的含量是人体其他部位细胞的10倍。巨大的生物量由400多种已知细菌组成,这些细菌产生强烈的代谢活性,对人类健康至关重要。常驻微生物群通过以下途径积极参与宿主保护:阻断病原体的定植、细胞结构和功能的发展、免疫系统的发展和炎症反应的调节、共生细菌影响介质的表达,如细胞内粘附分子I(ICAM-I)、E-选择素和白细胞介素(IL-8),共生细菌还调节免疫反应并增强细胞稳态机制。1当暴露在污染的水和食物等有毒物质以及不明智地使用抗生素时,这种生态系统会受到破坏。随着多种耐药菌株的出现,抗生素耐药性是一个日益重要的全球性问题。这会导致有益细菌的破坏,留下具有耐药性的致病菌。1随着细菌耐药性疾病的数量不断增加,以及开发新抗生素所需的时间越来越长,可能是时候考虑另一种替代方案了,例如在治疗牙周病时使用有益细菌“益生菌”,它可以刺激健康,促进本地菌群并逆转这种变化。
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引用次数: 0
Identification of Pencil-Using Skills of Children Aged 36-66 Months 36-66月龄儿童铅笔使用技能鉴定
Pub Date : 2017-12-19 DOI: 10.21276/2454-9916
Müge Yurtsever Kiliçgün, Ayşe Kiliçkaya
The aim of the current study was to identify pencil-using skills of the children aged 36-66 months. The sample of the study was consisted of 600 children who were attended preschool institutions. As data collection tools; “Observation form for pencil-using skills”, “goniometer” to identify positions of paper, sitting, shoulder, elbow, arm and wrist and “hand dynamometer” and “finger dynamometer” to measure hand-grip strength and compressive strength of fingers were used. Pencil-using skills were assessed under the titles of hand-preference, positions of paper, sitting, shoulder, elbow, arm and wrist, pencil-using skills and pencil-grip point, the number of the pencil-gripping fingers, position of thumb and flexion angle of index finger. According to the research findings; hand-preference, positions of paper, sitting, shoulder, elbow, arm and wrist, pencil-using skills and pencil-grip point, the number of the pencil-gripping fingers did not differ significantly in terms of gender whereas position of thumb and flexion angle of index finger was significantly different on behalf of girls. Positions of paper, sitting, shoulder, elbow, arm and wrist, pencil-using skills and pencil-grip point, position of thumb and flexion angle of index finger did not differ significantly in terms of age whereas the number of the pencil-gripping fingers was significantly different on behalf of children aged 49-60 months. Hand-grip strength and compressive strength of fingers of the children differed significantly on behalf of boys in terms of gender and those aged 61-66 months in terms of age.
目前这项研究的目的是确定36-66个月大的孩子使用铅笔的技能。该研究的样本由600名就读于学前机构的儿童组成。作为数据收集工具;使用“用笔技能观察表”,“测角仪”识别纸、坐、肩、肘、臂、腕的位置,“手测力仪”和“手指测力仪”测量手握力和手指抗压强度。使用铅笔的技能在“手偏好”、“纸张位置”、“坐姿”、“肩膀、肘部、手臂和手腕”、“使用铅笔技巧和握笔点”、“握笔手指数”、“拇指位置”和“食指屈曲角度”等题目下进行评估。根据研究结果;手偏好、纸张位置、坐姿、肩、肘、臂、腕、使用铅笔技巧、握笔点、握笔手指数量在性别上无显著差异,而女生的拇指位置和食指屈曲角度在性别上存在显著差异。纸、坐、肩、肘、臂、腕的体位、使用铅笔技巧和握笔点、拇指位置和食指屈曲角度在年龄上无显著差异,而49 ~ 60月龄儿童握笔手指数存在显著差异。男孩的握力和手指抗压强度在性别上存在显著差异,61 ~ 66月龄的儿童在年龄上存在显著差异。
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引用次数: 0
GREENHOUSE EFFECT AND GLOBAL WARMING 温室效应和全球变暖
Pub Date : 2017-11-22 DOI: 10.4324/9780203425305-13
N. Singh, Anoj Ekka, Dinanath
We face Conflicts between human development and nature Capacity to Provide The resources for such development. This is a great paradox the countries that have most benefited from industrial development by producing greenhouse gases. The atmosphere surrounding the earth, heats the soil and the Plants also. Greenhouse is the body which allows the short wave length incoming solar radiation to come in but does not allow the long wave outgoing terrestrial infrared radiation to scope in a way and atmosphere energy going up. Green house where co2 acts as like a glass windows. Co2 and water Vapors in the atmosphere transmit short wave length solar radiation but reflect the longer wave length heat radiation from warmed surface of the co2 molecules are transparent to sunlight but not to the heat re action .So the trap and re enforce the solar heat stimulating an effect which is properly known as Greenhouse effect.
人类的发展与自然提供人类发展资源的能力之间存在矛盾。这是一个巨大的悖论,那些从工业发展中受益最多的国家却产生了温室气体。环绕着地球的大气也给土壤和植物加热。温室是允许短波太阳辐射进入,但不允许长波地球红外辐射在某种程度上扩大范围和大气能量上升的主体。温室里的二氧化碳就像一扇玻璃窗。大气中的二氧化碳和水蒸气传输短波长的太阳辐射,但反射来自温暖的二氧化碳分子表面的短波长的热辐射,这些分子对阳光是透明的,但对热反应却不透明。因此,这种捕获和增强太阳热量的作用刺激了一种被恰当地称为温室效应的效应。
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引用次数: 1
A COMPARATIVE STUDY OF FIXATION OF PERTROCHANTERIC FRACTURES WITH DYNAMIC HIP SCREW AND PROXIMAL FEMORAL NAIL 动力髋螺钉与股近端钉固定股骨粗隆骨折的比较研究
Pub Date : 2017-07-01 DOI: 10.22271/ortho.2017.v3.i3l.124
Nadir Z. Shah, A. Singh, Arohi Sharma
Trochanteric femoral fractures are among the most common injuries necessitating hospital admission. Regardless the type of fracture, trochanteric fractures can lead to substantial morbidity and mortality , especially in elderly patients. [1,2] Surgery is the mainstay of the treatment for both displaced and non displaced trochanteric fractures, to allow early mobilization of the patient, depending on the stability of the reduction and fixation achieved. [4] Dynamic Hip Screw [DHS] as extramedullary and Proximal Femoral Nail [PFN] as intramedullary  systems are established and standard in treatment of trochanteric femoral fractures. [5,6] Aim: To compare the results of Dynamic Hip Screw and Proximal Femoral Nail in the treatment of intertrochanteric fractures. Materials & Methods: In our study we compared DHS with PFN in a group of 60 patients admitted in a tertiary care hospital between August 2013 – December 2016 . Patients  with intertrochanteric fractures  without having concomitant shaft femur or neck femur fractures  were included. The preoperative morbidity was evaluated using Parker’s mobility scale. Salvati and Wilson’s scoring helped in measuring overall functional outcome at 16 & 24 weeks between the two study groups. Results: The preoperative Parker’s mobility scale was comparable between two study groups. Salvati and Wilson’s score at 16 & 24 weeks was significantly better with PFN group. The functional outcome based on SWS score was Fair in 39% of patients operated with DHS at 16 weeks while for PFN it was Fair to Good in 79 % of patients . At 24 weeks it was Fair to Good in 84% patients operated with DHS while in case of PFN the score was Fair to Good in 59% of the patients & Excellent in 38% of the patients. Conclusion: Our conclusion from this study supported the use of PFN for both stable and unstable peritrochanteric fractures over DHS due to its lesser operation time, lesser blood loss, early weight bearing, limited open reduction & better functional outcome.
股骨转子骨折是最常见的需要住院治疗的损伤之一。无论何种类型的骨折,转子骨折可导致大量的发病率和死亡率,特别是在老年患者中。[1,2]手术是治疗移位和非移位转子骨折的主要方法,根据复位和固定的稳定性,允许患者早期活动。[4]动力髋螺钉(DHS)作为髓外系统和股骨近端钉(PFN)作为髓内系统被建立和规范用于治疗股骨粗隆骨折。[5,6]目的:比较动力髋螺钉与股近端钉治疗股骨粗隆间骨折的效果。材料与方法:在我们的研究中,我们比较了DHS和PFN在2013年8月至2016年12月期间在一家三级医院住院的60名患者。未合并股骨骨干或股骨颈骨折的股骨粗隆间骨折患者纳入研究。术前发病率采用帕克氏活动度量表评估。Salvati和Wilson的评分有助于测量两个研究组在16周和24周时的整体功能结果。结果:术前帕克氏活动量表在两个研究组之间具有可比性。PFN组在16周和24周时的Salvati和Wilson评分明显改善。基于SWS评分的功能结果在16周DHS手术的患者中有39%为一般,而在PFN手术的患者中有79%为一般至良好。在24周时,84%的DHS患者的评分从一般到良好,而在PFN的情况下,59%的患者的评分从一般到良好,38%的患者评分为优秀。结论:本研究的结论支持PFN用于DHS的稳定和不稳定转子周围骨折,因为PFN手术时间短,出血量少,早期负重,开放复位有限,功能预后好。
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引用次数: 0
Implementation and impact of sarfaesi act 2002 2002年《萨法西法》的实施和影响
Pub Date : 2017-05-24 DOI: 10.5958/2249-7137.2020.00998.2
M. Kumar, R. Khosla
Banks are the foundation of any nation as they are inescapable for the monetary advancement of a nation. Investors are the absolute entirety of any business. Banks are delegates between the investors and borrowers. This connection separates when the borrower neglect to reimburse the vital and premium sum; subsequently the banking segment concentrate on the issue of Non-Performing Assets. So far as India is worried, before 2002 banks have no alternative other than implementing the security through a court/tribunal, to recoup its duty. On the suggestion of Narasimham Committee –II SARFAESI Act 2002 came as a sigh of relief for the banking sector. This demonstration enabled the banks and budgetary organizations for the procurement of the secured resources of the borrowers held with the bankers at the time of availing loans. This paper endeavors to concentrate the execution and effect of SARFAESI Act 2002 for the administration of NPA in Indian Banking.
银行是任何国家的基础,因为它们对一个国家的货币发展是不可或缺的。投资者是任何企业的绝对整体。银行是投资者和借款人之间的代表。当借款人疏忽偿还生命和保险费时,这种联系就分开了;随后,银行部门集中精力处理不良资产问题。就印度所担心的而言,在2002年之前,银行除了通过法院/法庭实施担保,别无选择,以收回其责任。根据Narasimham委员会-II SARFAESI法案2002的建议,银行业松了一口气。这一示范使银行和预算组织能够获得借款人在获得贷款时在银行持有的有担保资源。本文试图集中研究2002年SARFAESI法案的执行和效果,为印度银行业的不良资产管理提供参考。
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引用次数: 0
STUDY OF TEACHER EFFICACY OF SECONDARY SCHOOL TEACHERS IN RELATION TO THEIR TEACHING COMPETENCY 中学教师效能感与教学能力的关系研究
Pub Date : 2017-05-02 DOI: 10.5958/2230-7311.2017.00012.5
Parmjot Kaur
Present study focuses on teacher efficacy of secondary school teachers and its relation with teaching competency. This study was carried out in rural and urban secondary school teachers. Data was collected mainly through questionnaire. Teacher Efficacy Scale (TES) by Kumar and General Teaching Competency Scale (GTCS) by Passi and Lalitha were used respectively. Sample of 200 urban and rural secondary school teachers were randomly selected for collecting data. This study demonstrated that there is a relationship between teacher efficacy and teaching competency. This study also revealed that there is significant difference between rural and urban secondary school teachers.
本研究主要研究中学教师的教师效能感及其与教学能力的关系。这项研究是在农村和城市中学教师中进行的。数据主要通过问卷调查收集。分别使用Kumar的教师效能感量表(TES)和Passi和Lalitha的一般教学能力量表(GTCS)。随机抽取200名城乡中学教师作为样本进行数据收集。本研究表明,教师效能感与教学胜任力之间存在一定的关系。本研究还表明,农村和城市中学教师之间存在显著差异。
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引用次数: 3
ESTIMATION OF MEAN TIME TO RECRUITMENT FOR A TWO GRADED MANPOWER SYSTEM WITH TWO THRESHOLDS, DIFFERENT EPOCH FOR EXITS AND CORRELATED INTER-DECISIONS UNDER CORRELATED WASTAGE 相关损耗下具有两个阈值、不同退出时间和相关决策的两级人力系统平均招聘时间估计
Pub Date : 2016-12-31 DOI: 10.21474/IJAR01/2640
L. Saral, S. Selvi, A. Srinivasan
In this paper, an organization with two grades, subjected to exit of personnel due to policy decisions taken by the organization is considered. As the exit of personnel is unpredictable a univariate recruitment policy involving two thresholds one is optional and other is mandatory is suggested to enable the organization to plan its decision on recruitment. Assuming that the policy decisions and exits occur at different epochs, a stochastic model is constructed and the mean time to recruitment is obtained when the loss of manpower at each decision epoch are identically distributed constantly correlated and exchangeable exponential random variables, thresholds follows independent and identically distributed exponential random variables , the inter-policy decision times are identically distributed constantly correlated and exchangeable exponential random variables  and inter-exit times form an ordinary renewal process.
本文考虑一个有两个等级的组织,由于组织的政策决定而导致人员的退出。由于人员的退出是不可预测的,建议采用涉及两个门槛的单变量招聘政策,一个是可选的,另一个是强制性的,以使组织能够计划其招聘决定。假设决策和退出发生在不同时期,构建随机模型,得到每个决策时期的人力损失为同分布、不断相关且可交换的指数随机变量,阈值为独立且同分布的指数随机变量时的平均招聘时间。政策间决策时间是同分布、不断相关、可交换的指数随机变量,退出间决策时间形成一个普通的更新过程。
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引用次数: 0
RAPAMYCIN INCREASES LENGTH AND MECHANOSENSORY FUNCTION OF PRIMARY CILIA IN RENAL EPITHELIAL AND VASCULAR ENDOTHELIAL CELLS. 雷帕霉素增加了肾上皮细胞和血管内皮细胞初级纤毛的长度和机械感觉功能。
Rinzhin T Sherpa, Kimberly F Atkinson, Viviana P Ferreira, Surya M Nauli

Primary cilia arebiophysically-sensitive organelles responsible for sensing fluid-flow and transducing this stimulus into intracellular responses. Previous studies have shown that the primary cilia mediate flow-induced calcium influx, and sensitivity of cilia function to flow is correlated to cilia length. Cells with abnormal cilia length or function can lead to a host of diseases that are collectively termed as ciliopathies. Rapamycin, a potent inhibitor of mTOR (mammalian target of rapamycin), has been demonstrated to be a potential pharmacological agent against the aberrant mTOR signaling seen in ciliopathies such as polycystic kidney disease (PKD) and tuberous sclerosis complex (TSC). Here we look at the effects of rapamycin on ciliary length and function for the first time. Compared to controls, primary cilia in rapamycin-treated porcine renal epithelial and mouse vascular endothelial cells showed a significant increase in length. Graded increases in fluid-shear stress further indicates that rapamycin enhances cilia sensitivity to fluid flow. Treatment with rapamycin led to G0 arrest in porcine epithelial cells while no significant change in cell cycle were observed in rapamycin-treated mouse epithelial or endothelial cells, indicating a species-specific effect of rapamycin. Given the previousin vitro and in vivo studies establishing rapamycin as a potential therapeutic agent for ciliopathies, such as PKD and TSC, our studies show that rapamycin enhances ciliary function and sensitivity to fluid flow. The results of our studies suggest a potential ciliotherapeutic effect of rapamycin.

初级纤毛是生物物理敏感的细胞器,负责感知流体流动并将这种刺激转化为细胞内反应。已有研究表明,初级纤毛介导血流诱导的钙内流,纤毛功能对血流的敏感性与纤毛长度有关。纤毛长度或功能异常的细胞可导致一系列统称为纤毛病的疾病。雷帕霉素是一种有效的mTOR(哺乳动物雷帕霉素靶点)抑制剂,已被证明是一种潜在的药物,可用于治疗多囊肾病(PKD)和结节性硬化症(TSC)等纤毛病中异常的mTOR信号。本文首次探讨了雷帕霉素对纤毛长度和功能的影响。与对照组相比,雷帕霉素处理的猪肾上皮细胞和小鼠血管内皮细胞的初级纤毛长度显着增加。流体剪切应力的逐渐增加进一步表明雷帕霉素增强了纤毛对流体流动的敏感性。雷帕霉素处理导致猪上皮细胞G0阻滞,而在雷帕霉素处理的小鼠上皮细胞或内皮细胞中未观察到细胞周期的显著变化,表明雷帕霉素具有物种特异性作用。鉴于之前的体外和体内研究证实雷帕霉素是一种潜在的治疗纤毛病的药物,如PKD和TSC,我们的研究表明雷帕霉素可以增强纤毛功能和对液体流动的敏感性。我们的研究结果提示雷帕霉素有潜在的纤毛治疗作用。
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引用次数: 0
DIGITAL INDIA: LABOUR REFORMS AND CHALLENGES 数字印度:劳动力改革和挑战
Pub Date : 2016-04-18 DOI: 10.2139/SSRN.2712168
S. Deo
'Digital India' is yet another initiative with a vision to digitally empower each and every citizen of the country. Digital India project aims at broadening the digital access for Indians and making sure government functions and services are available online to citizens. It hopes to launch a number of health, education and governance initiatives digitally in an attempt to deliver the essential services to all citizens even in far-flung areas.
“数字印度”是另一项旨在赋予该国每一位公民数字权力的倡议。数字印度计划旨在扩大印度人的数字访问,并确保公民可以在线获得政府职能和服务。它希望以数字方式发起若干保健、教育和治理举措,以便向所有公民,甚至是偏远地区的公民提供基本服务。
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引用次数: 0
E TEACHER – A BLOOMING BOON 老师——一朵盛开的恩惠
Pub Date : 2016-02-15 DOI: 10.2139/ssrn.2712169
S. Deo
We are using technology in every sphere of our lives. Then why teaching should be left behind. The age old practice of teaching that is a teacher coming to a class engaging lecture for an hour, at about the same time, chanting the canons is a regular feature of her one hour class. This all is quite boring also for the students. Few students just attend the class for the sake of attendance only. So it is really important to bring a change in the age old method of teaching. Since also now days we are experiencing that many colleges are setting up their campuses at outskirt of cities or there are few students whose colleges are in another city and have to travel such distance daily. Same is the case with teachers too. What will be situation if good education is very accessible?  It is possible through e-learning and e-teaching.  We are using technology in every sphere of our lives. Then why teaching should be left behind. The age old practice of teaching that is a teacher coming to a class engaging lecture for an hour, at about the same time, chanting the canons is a regular feature of her one hour class. This all is quite boring also for the students. Few students just attend the class for the sake of attendance only. So it is really important to bring a change in the age old method of teaching. Since also now days we are experiencing that many colleges are setting up their campuses at outskirt of cities or there are few students whose colleges are in another city and have to travel such distance daily. Same is the case with teachers too. What will be situation if good education is very accessible?  It is possible through e-learning and e-teaching.
我们生活的方方面面都在使用科技。那么为什么教学应该被抛在后面。一种古老的教学方式是,一位老师在课堂上讲了一个小时的课,在大约同一时间,诵经是她一小时课的常规特征。这对学生来说也很无聊。很少有学生只是为了出勤而上课。因此,改变陈旧的教学方法是非常重要的。从现在起,我们正经历着许多大学都把校园设在城市的郊区,或者很少有学生的大学在另一个城市,每天都要走这么远。教师也是如此。如果良好的教育很容易获得,情况会怎样?这可以通过电子学习和电子教学实现。我们生活的方方面面都在使用科技。那么为什么教学应该被抛在后面。一种古老的教学方式是,一位老师在课堂上讲了一个小时的课,在大约同一时间,诵经是她一小时课的常规特征。这对学生来说也很无聊。很少有学生只是为了出勤而上课。因此,改变陈旧的教学方法是非常重要的。从现在起,我们正经历着许多大学都把校园设在城市的郊区,或者很少有学生的大学在另一个城市,每天都要走这么远。教师也是如此。如果良好的教育很容易获得,情况会怎样?这可以通过电子学习和电子教学实现。
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引用次数: 0
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International education and research journal
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