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Effect of Laurusnobilis extract and Atorvastatin on Liver and Kidney function of Hyperlipidemia Male Rats 月桂提取物和阿托伐他汀对高脂血症雄性大鼠肝肾功能的影响
Pub Date : 2022-01-01 DOI: 10.37506/ijop.v10i1.3208
Faraj Hato
Introduction: Hyperlipidemia associated with increase of atherosclerosis and heart, blood vessels diseases. the present study was discuss of potentials effect of bay leave extract (BLE) and atorvastatin drug at diet with high fat, feeding rat types. Material and Methods: The Rats were randomly classificationfor 4 groups each group have 10 rats. control feed standard diet, group two rats feed HFD, group three rats feed HFD + ( BLE 250mg/kg ) and group four rats feed HFD + Atorvastatin 20 mg/kg in the experiment, the treatment done by gavage and treated with 4 weeks daily. Results and Conclusion : The results show increased significantly at the end body weights also the weight gain at group two by treated (HFD) , while hepatic levels was inhibited for the cholesterol, and also triglycerides, also the low-density lipoprotein cholesterol; While the hepatic levels and serum of high-density lipoprotein cholesterol may be increased when the animal treated 250 mg/kg BLE and 20mg/kg atorvastatin , also the result showed increased significantly in serum AST ,ALT, ALP, urea and creatinine in group of animals treated HFD , and caused decreased significantly in the value of above parameters when the animals treated 250 mg/kg BLE and 20mg/kg atorvastatin ,it reach the control. In conclusion, bay leave exerts and atorvastatin have amelioration effect against hyperlipidemia in HFD-fed rats.
导读:高脂血症与动脉粥样硬化和心脏、血管疾病的增加有关。本研究探讨了月桂叶提取物(BLE)和阿托伐他汀药物在高脂饲粮、饲养型大鼠中的潜在作用。材料与方法:将大鼠随机分为4组,每组10只。对照组饲喂标准日粮,2组大鼠饲喂HFD, 3组大鼠饲喂HFD + (BLE 250mg/kg), 4组大鼠饲喂HFD +阿托伐他汀20mg /kg,采用灌胃方式,每天给药4周。结果与结论:结果表明:处理组(HFD)末重和增重显著增加,肝脏胆固醇、甘油三酯、低密度脂蛋白胆固醇水平受到抑制;250mg /kg BLE和20mg/kg阿托伐他汀可使肝脏高密度脂蛋白胆固醇水平和血清升高,HFD组血清AST、ALT、ALP、尿素和肌酐均显著升高,250mg /kg BLE和20mg/kg阿托伐他汀可使上述参数值显著降低,达到对照水平。由此可见,香叶提取物和阿托伐他汀对hfd喂养大鼠的高脂血症有改善作用。
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引用次数: 0
The effect of weight bearing exercises on Spastic Diplegic Children 负重运动对痉挛性双瘫儿童的影响
Pub Date : 2022-01-01 DOI: 10.37506/ijop.v10i3.3294
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引用次数: 0
Physiological and Motor Performance Characteristics in Rugby and Soccer Players: Data from a Developing Country 橄榄球和足球运动员的生理和运动表现特征:来自发展中国家的数据
Pub Date : 2022-01-01 DOI: 10.37506/ijop.v10i4.3342
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引用次数: 0
Comparative Study Of Physical Fitness Index And Predicted VO2max among Rural And Urban Female Students 城乡女大学生体质指数与预测VO2max的比较研究
Pub Date : 2022-01-01 DOI: 10.37506/ijop.v10i2.3253
G.Suneethi
Background: Physical fitness index (PFI) measures fitness for muscular work and ability to recover from work. It assess cardiopulmonary efficiency. Vo2 max refers to maximum amount of oxygen that an individual can utilize during intense exercise and is best indicator of cardiovascular fitness and aerobic endurance. PFI and Vo2 max are dependent on height, weight, BMI. Differences in anthropometry among urban and rural subjects due to different environmental, social, nutritional and life style habits can affect PFI and Vo2 max. Thus present study is intended to compare PFI and predicted Vo2 max among rural and urban female students . Materials and Methods: 50 participants of age group 18-20 years, 25 sedentary female subjects from each of rural and urban sectors of 1 st year MBBS were taken by random sampling. PFI was determined by modified Harvard step test and Vo2 max was determined by Indirect Queens college step test. Mean PFI was higher in rural group compared to urban group (p= 0.48). Mean Vo2 max was similar in both the groups (p=0.99). PFI was positively correlated with Vo2 max in both the groups (p<0.05). Conclusion: Rural female students do not have a statistically significant higher value of PFI and Vo2 max than urban female students.
背景:身体健康指数(Physical fitness index, PFI)衡量肌肉运动的适应性和从工作中恢复的能力。它评估心肺效率。最大摄氧量指的是一个人在剧烈运动中可以利用的最大氧气量,是心血管健康和有氧耐力的最佳指标。PFI和Vo2 max取决于身高,体重,BMI。由于不同的环境、社会、营养和生活方式习惯,城乡受试者的人体测量差异会影响PFI和Vo2 max。因此,本研究旨在比较农村和城市女学生的PFI和预测Vo2 max。材料与方法:采用随机抽样的方法,从MBBS一年级的农村和城市各抽取年龄在18-20岁的女性受试者各25名。PFI采用改良哈佛步进法测定,Vo2 max采用间接皇后学院步进法测定。农村组平均PFI高于城市组(p= 0.48)。两组平均最大摄氧量相似(p=0.99)。两组PFI与Vo2 max呈正相关(p<0.05)。结论:农村女生的PFI和Vo2 max值均不高于城市女生,差异无统计学意义。
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引用次数: 0
Assessment of Post – COVID 19 Sequelae: A Retrospective Study COVID - 19后后遗症评估:一项回顾性研究
Pub Date : 2022-01-01 DOI: 10.37506/ijop.v10i2.3252
D. Celine, S.Suguna, M.Nishanth
Background: COVID–19 is an acute respiratory illness caused by SARS–CoV–2. COVID-19 created a major impact on physical, cognitive, mental health and social status in patients with SARS–CoV–2. Aim and Objective : To assess the post COVID sequelae in COVID19 recovered individuals. To assess the functional limitations using post COVID functional status scale after 4weeks of onset of illness. Materials and Methods : Subjects were selected from compiled list of Triage OP from Chengalpattu Medical College and Hospital. The semi structured questionnaire enclosed with Socio – demographic details, physical and socio – psychological domains based on COVID-19 Yorkshire Rehabilitation Screening tool (C19-YRS) were assessed and the impact of each domain was graded using a Likert scale. Post – COVID 19 functional status scale (PCFS) to assess functional limitations was also sent through Google form and the details were collected. Analysis: Collected data was analyzed using Microsoft Excel with descriptive statistics. Result: 1044 individuals participated in the study. On Assessment of post COVID sequelae fatigue was major symptom reported followed by cough and other neuropsychiatric symptoms. 53.4% of COVID recovered individuals had functional limitations and 2.4% of these individuals had severe functional limitations and they require assistance for daily living. Conclusion: Most COVID–19 recovered individuals had persistence of some clinical symptoms. From PCFS it was observed that 23% individuals had moderate to severe functional limitations, therefore early detection and rehabilitation measures are recommended.
背景:COVID-19是由SARS-CoV-2引起的急性呼吸道疾病。COVID-19对SARS-CoV-2患者的身体、认知、心理健康和社会地位产生了重大影响。目的与目的:了解新型冠状病毒感染症(COVID - 19)患者康复后的后遗症情况。采用发病4周后功能状态量表评估患者功能受限情况。材料与方法:研究对象选自成都市医学院医院编撰的分诊门诊目录。采用基于COVID-19约克郡康复筛查工具(C19-YRS)的半结构化问卷,对社会人口学细节、身体和社会心理领域进行评估,并使用李克特量表对每个领域的影响进行评分。通过谷歌表格发送评估功能限制的新冠肺炎后功能状态量表(PCFS),并收集详细信息。分析:收集的数据使用Microsoft Excel进行描述性统计分析。结果:1044人参与了这项研究。冠状病毒感染后的主要症状是疲劳,其次是咳嗽等神经精神症状。53.4%的康复患者有功能限制,其中2.4%有严重功能限制,日常生活需要帮助。结论:大多数COVID-19康复者仍存在部分临床症状。从PCFS中观察到,23%的个体有中度至重度功能限制,因此建议早期发现和康复措施。
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引用次数: 0
Genetican Alysis of the Role of Connexin 37 Polymorphism in Spontaneous Abortion 连接蛋白37多态性在自然流产中的遗传分析
Pub Date : 2021-08-27 DOI: 10.37506/ijop.v9i4.3088
Nayela Sayeed, W. Nagadeepa, Vemulapalli Ravi Kumar
Introduction: Among unique cardiovascular risk factors in women are complications during pregnancy,including miscarriage. Important risk factor is also genetic background. One of powerful candidate genesfor cardiovascular disease of atherosclerotic origin (aCVD) is gene for connexin 37 (Cx37) with stronggene-environment interaction including smoking status, that is also strong risk factor for complications inpregnancy including spontaneous abortion (SA). Material and Methods: We analysed association betweenSA and Cx37 gene polymorphism (1019C>T; Pro319Ser) in 547 foetuses and its potential interaction withsmoking status of mothers. Using genetic analyses from women from general population as controls, ORsfor T allele, found in our previous studies to be protective against a CVD, were calculated. This study wasa secondary analysis of a randomized controlled trial. Results and Conclusion: T allele carriers (foetuses),had OR 0.91 (95 % CI 0.72-1.14) and no interaction with smoking was observed. In conclusion, no significantassociation between Cx37 polymorphism and SA was observed and no modifying effect of smoking statuson this association was detected.
妇女独特的心血管危险因素是妊娠期间的并发症,包括流产。遗传背景也是一个重要的风险因素。连接蛋白37 (Cx37)基因是动脉粥样硬化源性心血管疾病(aCVD)的一个强有力的候选基因,它具有包括吸烟状况在内的强基因-环境相互作用,也是妊娠并发症(包括自然流产(SA))的强烈危险因素。材料与方法:我们分析了sa与Cx37基因多态性(1019C >t;547例胎儿中Pro319Ser的表达及其与母亲吸烟状况的潜在相互作用。通过对普通人群女性的遗传分析作为对照,我们计算了在我们之前的研究中发现的对心血管疾病有保护作用的T等位基因的ors。本研究是一项随机对照试验的二次分析。结果与结论:T等位基因携带者(胎儿)的OR为0.91 (95% CI 0.72 ~ 1.14),与吸烟无交互作用。综上所述,Cx37多态性与SA之间没有显著的相关性,吸烟状态也没有改变这种相关性。
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引用次数: 0
A Study of Lipid Profile in Obese Hypertensive Subjects 肥胖高血压患者血脂水平的研究
Pub Date : 2021-08-27 DOI: 10.37506/ijop.v9i4.3086
Anant Kumar, R. Ranjan, Priyanka., V. Rani, R. Singh
Background: Obesity is a significant risk factor for metabolic syndrome in adults. Central fat distributiongreatly alters the lipid profile and induces atherogenic dyslipidemia even in normoglycaemic, nonhypertensivesubjects.Aim and Objectives: Hence, the aim of the present study to assess lipid profile changes in non-obesehypertensive subjects. Obesity, hypertension and dyslipidemia are the three highly significant risk factorfor the deranged lipid profile. Obesity can be defined as excess accumulation of body fat arising froma sustained or a periodic positive energy balance that when energy intake exceeds energy expenditure1.Indicators of overweight are useful in the diagnosis and management of obesity in both children and adults.Material & Methods: This study was conducted on newly diagnosed cases of essential hypertensionattending medical outdoor of M.G.M. Medical College, Kisangani. A complete clinical examinationincluding laboratory investigation was done to exclude any systemic or other diseases which are likely toaffect blood lipid levels directly or indirectly.Results- The association between dyslipidaemia, obesity and hypertension is well establishedand all havebeen found to be major risk factor for the development of CAD, a leading cause of visits to physician andcause of death .Conclusion: Our study was envisaged to know the effect of obesity on lipid profile profile only inhypertensive and not in general population, and the study found some definite but paradoxical effects.These are that in obesity on a background of hypertension, the total and LDL cholesterol as also the HDLcholesterol are decreased, but on use other hand, the value of VLDL cholesterol and triglycerides are grosslyand significantly increased. These finding have two major Clinical implications in that obese hypertensiveswill be more prone to metabolic syndrome and type 2 diabetes mellitus, and steps should be taken to preventthem accordingly and also apart from statins one should treat the obese hypertensives with fibrates, fatrestriction and physical exercise also.
背景:肥胖是成人代谢综合征的重要危险因素。即使在血糖正常、无高血压的受试者中,中心脂肪分布也会极大地改变脂质谱,诱发动脉粥样硬化性血脂异常。目的和目的:因此,本研究的目的是评估非肥胖性高血压受试者的血脂变化。肥胖、高血压和血脂异常是血脂异常的三个高度显著的危险因素。肥胖可以定义为当能量摄入超过能量消耗时,由于持续的或周期性的正能量平衡而引起的体内脂肪的过度积累。超重指标对儿童和成人肥胖的诊断和管理都是有用的。材料与方法:对基桑加尼M.G.M.医学院室外内科新诊断的原发性高血压患者进行研究。完整的临床检查包括实验室检查,以排除任何可能直接或间接影响血脂水平的全身性或其他疾病。结果-血脂异常、肥胖和高血压之间的关系已经得到了很好的确立,并且都被发现是冠心病发展的主要危险因素,冠心病是就诊的主要原因和死亡的主要原因。结论:我们的研究旨在了解肥胖对血脂的影响,仅在高血压患者中,而不是在一般人群中,研究发现了一些明确但矛盾的影响。在高血压背景下的肥胖中,总胆固醇和低密度脂蛋白胆固醇以及高密度脂蛋白胆固醇都降低了,但另一方面,VLDL胆固醇和甘油三酯的值却显著升高。这些发现有两个主要的临床意义,即肥胖高血压更容易发生代谢综合征和2型糖尿病,应该采取相应的措施来预防它们,除了他汀类药物外,还应该用贝特类药物、限制脂肪和体育锻炼来治疗肥胖高血压。
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引用次数: 0
A Study of Red Blood Cell Indices among Covid 19 Individuals in Tertiary Care Triage Centre 三级医疗分诊中心新冠肺炎患者红细胞指标的研究
Pub Date : 2021-08-27 DOI: 10.37506/ijop.v9i4.3085
A.Anitha, P.Sudhakar, S.Ramapriya
Background: SARS-CoV-2 infection is characterized by the development and progression of inflammatoryresponses. The exploration of prognostic predictors for patients with COVID-19 is vital for prompt clinicalintervention. Our study aims to explore the predictive value of hematological parameters in categorizationof patients with COVID-19.We aimed to investigate associations between hematological parameters anddisease severity in patients with SARS-CoV-2infection.The red blood cell distribution width (RDW),an indicator of anisocytosis has emerged as a potential tool for risk stratification of critically ill patients.Materials and Methods: Retrospective study after getting approval from Institutional ethics committeewas performed with data obtained from triage OPD in Chengalpattu Medical College & Hospital. Thedemographic, clinical, laboratory profile of COVID 19 positive patients who attended Triage OPD for aperiod of one month were collected. 3000 RT-PCR confirmed COVID positive patients of age group 20to 70 years of both genders were included in the study. COVID 19 positive paediatric cases, antenatal andpostnatal mothers, postoperative cases and sick cases admitted in COVID ICU were excluded from thestudy. Symptoms, associated co-morbidities and severity of COVID 19 were tabulated. Complete BloodCount measured by Automated Sysmex Analyser at the time of reporting to triage was noted. Red bloodcell indices were analysed using SPSS 21.0 version. Results: There was statistically significant increase inRDW and decrease in MCV among patients with co-morbidity and severe illness compared to those withmild disease. There is no statistically significant difference in Red blood cell indices between patients withand without symptoms and patients without co-morbidities. Conclusion: RDW was found to be a screeningtool to identify patients with severe COVID-19 and the results of this study suggest that RDW should be partof routine laboratory assessment and monitoring of COVID-19.
背景:SARS-CoV-2感染的特点是炎症反应的发生和进展。探索COVID-19患者的预后预测因素对于及时进行临床干预至关重要。本研究旨在探讨血液学参数对COVID-19患者分类的预测价值。我们的目的是研究sars - cov -2感染患者血液学参数与疾病严重程度之间的关系。红细胞分布宽度(RDW),一个指标的红细胞各向异性已成为一个潜在的工具,危险分层危重患者。材料与方法:经机构伦理委员会批准后,采用成都医学院附属医院分诊科的资料进行回顾性研究。收集在分诊门诊就诊1个月的COVID - 19阳性患者的人口学、临床和实验室资料。本研究纳入了3000名年龄在20 ~ 70岁的男性和女性的RT-PCR确诊的COVID阳性患者。排除COVID - 19阳性儿科病例、产前和产后母亲、术后病例和COVID - 19 ICU住院病例。将COVID - 19的症状、相关合并症和严重程度制成表格。在报告分诊时,全自动Sysmex分析仪测量的全血细胞计数被记录。红细胞指标分析采用SPSS 21.0版本。结果:与轻症患者相比,合并重症患者的rdw升高,MCV降低,具有统计学意义。有、无症状和无合并症患者的红细胞指标无统计学差异。结论:RDW是一种筛查COVID-19重症患者的工具,本研究结果提示RDW应作为COVID-19常规实验室评估和监测的一部分。
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引用次数: 0
A Study on Neutrophil Lymphocyte Ratio in Covid 19 Patients in Tertiary Care Centre 三级医疗中心新冠肺炎患者中性粒细胞比例的研究
Pub Date : 2021-08-27 DOI: 10.37506/ijop.v9i4.3087
Céline, T. Vijayalakshmi, G. Chandini
Introduction: COVID-19 pandemic is spread by droplet infectionwith symptoms of fever, cough,diarrhea,dyspnea, fatigue, myalgia, headache, anosmia and ageusia. Morbidity and mortality is higher amongelderly and in patients with comorbidities especially Diabetes Mellitus(DM). Biomarkers of inflammationare potential predictors for prognosis in covid patients.Aim: To analyze the association of NLR in covid 19 patients with symptoms and diabetic status Objective:1. To studyNLR in covid 19 patients with and without symptoms2. To study the association of NLR between diabetic and non-diabetic covid 19 patients.3. To study the association between symptomatology and NLR in diabeticcovid 19 patients.Methodology: 3000 RT-PCR confirmed Covid 19 patients who attended triage op were included afterEthicscommittee approval.Patients were grouped as patients with and without symptoms and patients with andwithout DM.The diabetic Covid patients were also analyzed based on the symptoms. Blood samplesonreporting were used for analysis of NLR andparameters analyzed using SPSS23.0 version.Result: There is no statistically significant difference in NLR among Covid symptomatic and asymptomaticpatients. But NLR is markedly raised in covid symptomatic patients with diabetes mellitus.
导语:COVID-19大流行通过飞沫感染传播,症状为发热、咳嗽、腹泻、呼吸困难、疲劳、肌痛、头痛、嗅觉丧失和衰老。发病率和死亡率在老年人和有合并症特别是糖尿病(DM)的患者中较高。炎症生物标志物是covid患者预后的潜在预测因素。目的:分析新冠肺炎患者NLR与症状和糖尿病状态的关系。研究有症状和无症状的covid - 19患者的ynlr。2 .研究糖尿病与非糖尿病患者NLR的相关性。目的:探讨糖尿病患者症状学与NLR的关系。方法:经伦理委员会批准,纳入3000例参加分诊手术的RT-PCR确诊的Covid - 19患者。将患者分为有症状和无症状患者、有dm和无dm患者,并根据症状对糖尿病新冠患者进行分析。采用报告血样进行NLR分析,参数分析采用SPSS23.0版本。结果:新冠肺炎有症状和无症状患者NLR差异无统计学意义。但在有新冠肺炎症状的糖尿病患者中,NLR明显升高。
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引用次数: 0
A Descriptive Study to Assess the Perceptions of Undergraduate Medical Students Towards Acceptance of E-Learning Vs Conventional Methods in An Integrated Curriculum in Physiology 一项描述性研究评估本科医学生在生理学综合课程中对接受电子学习与传统方法的看法
Pub Date : 2021-08-27 DOI: 10.37506/ijop.v9i4.3090
S. Ali, Hifzur Rehman, P. Ba
Background: Institutions across the world have shifted to virtual education to keep the academic activitiesgoing due to the COVID-19 pandemic jeopardizing the academiccalendars. E-learning was being used asa part of distance learning courses but the preparedness, designing and effectiveness in using it towardsconducting regular courses have been the main concern in countries where students are not used to virtualclasses due to technical constraints like faculty training, suitability of devices and bandwidth availabilityposing a serious challenge. Methods: A cross-sectional, web-based study was done among 50 second yearmedical undergraduate students in 2020. A standardized, electronic, self-administered, Google Form datacollection sheet was distributed. It included the seven components to evaluate; Course Schedule, objectives,time management, teaching methods, assessment methods, academic achievement and student concerns.Descriptive, inferential statistics were applied. Results: e-learning has been accepted very well by thestudents (48%) and they found it to add as a better learning resource (44%). About 25% of students find bothe-leaning and conventional methods as convenient in learning.The major advantage in conventional methodswere due to peer interaction, student-faculty interaction and active participation of faculty with feedback.Conclusion: Most of the students appraised that e-learning can be used as complementary to conventionalmethods. The conventional methods had an upper hand in long term; teaching concepts, peer interaction andfaculty feedback with better planning and implementation of curricular activities holding the key for successin fulfilling the expected outcomes by either of the methods.
背景:由于新冠肺炎疫情影响了学术日程,世界各地的机构都转向了虚拟教育,以保持学术活动的进行。电子学习已被用作远程学习课程的一部分,但在一些国家,由于教师培训、设备适用性和带宽可用性等技术限制,学生不习惯虚拟课程,因此将其用于常规课程的准备、设计和有效性一直是主要关注的问题。方法:对50名2020年医学本科二年级学生进行了一项基于网络的横断面研究。分发了一份标准化、电子、自我管理的谷歌表格数据收集表。它包括七个要评估的组成部分;课程安排、目标、时间管理、教学方法、评估方法、学习成绩和学生关注的问题。采用描述性、推断性统计。结果:学生对电子学习的接受程度很高(48%),他们认为电子学习是一种更好的学习资源(44%)。约25%的学生认为学习方法和传统方法都很方便。传统方法的主要优势在于同伴互动、师生互动以及教师的积极参与和反馈。结论:大多数学生认为网络学习可以作为传统方法的补充。从长期来看,传统方法具有优势;教学理念、同伴互动和教师反馈以及更好地规划和实施课程活动是两种方法成功实现预期结果的关键。
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引用次数: 0
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International journal of physiology
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