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A Study on Prevalence of Colour Vision Defects and Correlation with Sex, Visual Acuity and Blood Groups of the Study Group 色觉缺陷患病率及其与性别、视力、血型的相关性研究
Pub Date : 2021-01-27 DOI: 10.37506/IJOP.V9I1.2606
I. V. Padma, S. Panda
Inherited color blindness is a lifelong challenge. While it may limit prospects for certain jobs, most peoplefind ways to adapt to the condition. Colour vision defect is usually for red-green colour and it is X-linkedrecessive trait. It is mainly homozygous that develop colour vision defects. Female heterozygous usuallyhave normal vision. Colour vision defects also have a strong genetic component , especially if both parentshave colour vision defects , and people with a particular blood group , and very myopic or hypermetropic, there is a good chance their child will be same. Color blindness is often apparent at a young age whenchildren are learning their colours and goes undetected because as they grow they learn to associate specificcolours with certain objects.For example, they come to know that grass is green, so they call the colour theysee green. If symptoms are very mild, a person may not realize that they don’t see certain colours.
遗传性色盲是一项终身挑战。虽然这可能会限制某些工作的前景,但大多数人都会找到适应这种情况的方法。色觉缺陷通常是红绿色的,它是X连锁的反射性特征。主要是纯合子导致色觉缺陷。女性杂合子通常视力正常。色觉缺陷也有很强的遗传成分,尤其是如果父母都有色觉缺陷,而且有特定血型,而且近视或远视,他们的孩子很有可能是一样的。色盲通常在很小的时候就很明显了,当时孩子们正在学习自己的颜色,但却没有被发现,因为随着他们的成长,他们学会了将特定的颜色与某些物体联系起来。例如,他们知道草是绿色的,所以他们把看到的颜色叫做绿色。如果症状非常轻微,一个人可能没有意识到他们看不到某些颜色。
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引用次数: 1
Prevalence of High Risk Pregnancy: in A Tertiary Care Centre of Sagar Division of M.P. 高危妊娠的流行:在一个三级保健中心的Sagar省
Pub Date : 2021-01-27 DOI: 10.37506/IJOP.V9I1.2609
R. Arjariya, P. Tiwari
Background: High risk pregnancy is broadly defined as one in which mother, fetus or newborn is or will beat increased risk for morbidity or mortality before or after delivery. According to WHO, globally about 830women die from pregnancy or childbirth-related complications every day. About 20-30% of all pregnanciesbelong to high-risk category, which is responsible for 70–80% of perinatal mortality and morbidity.Hence, the current study was done to determine the prevalence of high-risk pregnancies and associated highrisk factors among antenatal women in a tertiary care centre of central India.Aims & Objectives: To know the prevalence of high-risk pregnancies and associated high risk factors.Materials and methods: Ethics approval to conduct the study was obtained from the Institutional EthicsCommittee. It is a record-based retrospective longitudinal study done among 3898 antenatal women whohave attended/ referred to our tertiary care institute, Bundelkhand Medical College, Sagar, M.P. duringFebruary 2020 to May 2020.High-risk pregnancy was classified based on the guidelines from the Pradhan Mantri Surakshit MatritvaAbhiyan.Results: Among 3898 antenatal case record reviewed. Results of this study show that the prevalence ofhigh-risk pregnancy among study participants was 16.54%.Most of the pregnant women were in age group of 20-35 years that is 94.72%.Most of the pregnant women were multigravida 57.20% by gestation.Regarding obstetric and neonatal outcomes, majority had normal vaginal delivery (60.6%). The mostcommon high risk factors were history of previous cesarean section 31.94 %, Hypertension in Pregnancy22.17% & Abnormal Presentation were 13.95%.Conclusion: The current study found that almost one-sixth (16.54%) of the pregnant women have highriskpregnancy. Hence, early detection of high-risk pregnancy needs to be done to improve the maternal,obstetric, and neonatal outcomes.
背景:高风险妊娠被广泛定义为母亲、胎儿或新生儿在分娩前或分娩后患病或死亡风险增加的妊娠。据世卫组织称,全球每天约有830名妇女死于妊娠或分娩相关并发症。约20-30%的妊娠属于高危妊娠,占围产期死亡率和发病率的70-80%。因此,目前的研究是为了确定高危妊娠的流行率和相关的高危因素在产前妇女在印度中部的三级保健中心。目的:了解高危妊娠的流行情况及相关高危因素。材料和方法:本研究的伦理批准已获得机构伦理委员会的批准。这是一项基于记录的回顾性纵向研究,在2020年2月至2020年5月期间,在我们的三级保健研究所(Bundelkhand Medical College, Sagar, mp)就诊/转诊的3898名产前妇女中进行。高危妊娠是根据Pradhan Mantri Surakshit MatritvaAbhiyan的指导方针进行分类的。结果:回顾了3898例产前病例。本研究结果显示,研究对象中高危妊娠发生率为16.54%。孕妇以20 ~ 35岁年龄组居多,占94.72%。多数孕妇为多胎妊娠(57.20%)。关于产科和新生儿结局,大多数正常阴道分娩(60.6%)。最常见的高危因素为有剖宫产史(31.94%)、妊娠高血压(22.17%)和异常表现(13.95%)。结论:本研究发现近六分之一(16.54%)的孕妇为高危妊娠。因此,需要及早发现高危妊娠,以改善孕产妇、产科和新生儿结局。
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引用次数: 0
Effect of Acute Warm Water Swim Stress on Antioxidant Levels in Swiss Albino Rats 急性温水游泳应激对瑞士白化大鼠抗氧化水平的影响
Pub Date : 2021-01-27 DOI: 10.37506/IJOP.V9I1.2604
B. Madhuri, R. Reddy
Background: Heat stress affects both physical and mental tasks. Imbalance in maintenance of temperatureleads to oxidative stress and damage to the body systems. Aim: To evaluate the effect of acute warm waterswim stress on antioxidant status changes in albino rats. Materials and Methods: The present study wasconducted in the Department of Physiology, Meenakshi medical College& Research Institute, Chennai.Twenty male albino rats were randomly divided in to two groups, control group and experimental group.Experimental group of rats were exposed to warm water swim stress at 40oc for duration of 15min ofcontinuous single exposure. The antioxidant status namely enzyme activity (LPO,CAT, SOD & GPx) andnon-enzyme activity (Vitamin C & Vitamin E) were estimated as per standard procedures. Results: Therewas a significant (P<0.001) increase in Lipid peroxidation and was significantly (P<0.001) decrease inenzyme activity (SOD, CAT, & GPx) and non- enzyme activity (Vitamin C & Vitamin E) when comparedwith their normal controls. Conclusion: The changes in antioxidant estimation helps in developing a newapproach in understanding the changes in the body under acute exposure to heat water swim stress whichis mainly responsible for pathophysiological changes and to know the thermoregulatory activities of themammals.
背景:热应激影响体力和脑力。温度维持不平衡会导致氧化应激和身体系统损伤。目的:评价急性温水游泳应激对白化病大鼠抗氧化状态变化的影响。材料和方法:本研究在金奈Meenakshi医学院和研究所生理学系进行。20只雄性白化大鼠随机分为对照组和实验组。实验组大鼠在40℃的温水游泳应激下连续单次暴露15min。根据标准程序评估抗氧化状态,即酶活性(LPO、CAT、SOD和GPx)和非酶活性(维生素C和维生素E)。结果:与正常对照组相比,脂质过氧化显著增加(P<0.001),酶活性(SOD、CAT和GPx)和非酶活性(维生素C和维生素E)显著降低(P<0.01)。结论:抗氧化剂估计的变化有助于开发一种新的方法来理解急性暴露于热水游泳应激下身体的变化,这主要是病理生理变化的原因,并了解哺乳动物的体温调节活性。
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引用次数: 0
Mechanism of Biological Aging-A Review 生物衰老机制研究进展
Pub Date : 2021-01-27 DOI: 10.37506/IJOP.V9I1.2607
Namita, M. Mondal, Bandhu Bandhu
Aging is a universal, inherent, natural phenomenon that occurs in all organism. Aging involves morphologicaland functional changes in cellular and extracellular components leading to progressive decline in mostbiological functions. It causes reduction in strength, basal metabolism, sexual activity and the body’sdefenses.Aging is the progressive decline in the maintenance of homeostasis, which leads to decreased response ofthe body against internal and external stress. It involves imbalance between free radicals and the antioxidantmechanism lead to damaged cells, tissues, and organs resulting in age related changes.With age there is modifications in energy metabolism, insulin sensitivity, neuroendocrine function andinduction of hormesis response. Telomere shortening, mitochondrial dysfunction, increase of oxidativestress, alteration of insulin-like growth factor and growth hormone signaling are considered to be importantcontributors of aging process.Recently many genes and changes in gene expression have been found associated with aging which affectsmany biological processes and are associated with senescence and oxidative stress.This review focuses on the underlying mechanism of biological aging. With an increase in the number ofelderly population and the patients of age-related diseases, it is becoming increasingly important to considerthese in the field of research. We have attempted to discuss the different aging mechanism along with thenewer concepts, which can give a direction for the future research studies.
衰老是一种普遍的、固有的、自然的现象,发生在所有生物体中。衰老涉及细胞和细胞外成分的形态和功能变化,导致大多数生物功能的逐渐下降。它会导致力量、基础代谢、性活动和身体防御能力的下降。衰老是维持体内平衡的能力逐渐下降,导致身体对内外压力的反应减弱。它涉及自由基和抗氧化机制之间的不平衡,导致细胞、组织和器官受损,从而导致与年龄相关的变化。随着年龄的增长,能量代谢、胰岛素敏感性、神经内分泌功能和激效反应的诱导都发生了变化。端粒缩短、线粒体功能障碍、氧化应激增加、胰岛素样生长因子和生长激素信号的改变被认为是衰老过程的重要因素。近年来,人们发现了许多与衰老相关的基因及其表达变化,衰老影响许多生物过程,并与衰老和氧化应激有关。本文就生物衰老的潜在机制作一综述。随着老年人口和老年相关疾病患者数量的增加,在研究领域考虑这些问题变得越来越重要。我们试图探讨不同的衰老机制以及新的概念,为未来的研究提供方向。
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引用次数: 0
Major Depression Induced Endocrine Modulation is a Risk Factor for Low bone Mineral Density in Premenopausal Women 重度抑郁诱导的内分泌调节是绝经前妇女低骨密度的危险因素
Pub Date : 2021-01-27 DOI: 10.37506/IJOP.V9I1.2608
P. Pahari, Vinita Ailani, J. Bhattacharya, Ritwik Ganguli
Background: The significant physiological effects of psychological depression are beginning to berecognized as exacerbating common diseases, including osteoporosis. This review discusses the currentevidence for psychological depression-associated mental health disorders as risk factors for osteoporosis,the mechanisms that may link these conditions, and potential implications for treatmentOsteoporosis is a major public health threat and depression is second most important cause of disabilityworldwide in 2020. Several studies have reported an association between depression and low bone mineraldensity, but a causal link between these two conditions is disputed.We propose that depression induces earlybone loss in premenopausal women, primarily via specific endocrine mechanisms associated poor lifestylehabits contributory.Aim and Objectives: To find the clinical correlation between depression, serum cortisol, vitamin D,hypothyroidism and BMD in Premenopausal Women.To find out a new risk factor of secondary osteoporosis in premenopausal women.Methods: The study group consisted of 80 osteoporotic female patient’s age range between 30-60years.Thestate of depression was analyzed by using Ham D scale. BMD and endocrine parameters was measured byDEXA and chemiluminisence,ELISA. Statistical correlation analyzed by SPSS22software.Results: A highly significant (P <0.00001) correlation was observedbetween HAM-D score and serumcortisol. The correlation between HAM-D and BMD was also significant (P <0.05).No significant correlationwas found between BMD and serum cortisol (P? 0.05).The correlation of serum vitamin D with BMD wasfar more significant (P<0.00001) compared to the association with TSH (P<0.0001).Discussion & Conclusion: A high score of depression associated with low vitamin D level or high serumcortisol and TSH level which is a risk factor for low BMD in premenopausal women to develop secondaryosteoporosisIt can be concluded that Irrespective of the specific causes, subjects with depression should be consideredfor screening for bone mineral density and, vice versa, subjects with low BMD should be considered forscreening for depression in early stage of life and supplementation of vitamin D with regular physicalactivity in premenopausal women for prevention of secondary osteoporosis.
背景:人们开始认识到心理抑郁的显著生理效应会加剧常见疾病,包括骨质疏松症。这篇综述讨论了目前关于心理抑郁相关的精神健康障碍作为骨质疏松症危险因素的证据,可能与这些疾病相关的机制,以及对治疗的潜在影响。骨质疏松症是一个主要的公共卫生威胁,抑郁症是2020年全球第二大致残原因。一些研究报告了抑郁症和低骨矿物质密度之间的联系,但这两种情况之间的因果关系存在争议。我们认为抑郁症诱发绝经前妇女早期骨质流失,主要是通过与特定内分泌机制相关的不良生活习惯促成的。目的:探讨绝经前妇女抑郁、血清皮质醇、维生素D、甲状腺功能减退和骨密度的临床相关性。探讨绝经前妇女继发性骨质疏松症的一个新的危险因素。方法:研究对象为80例骨质疏松症女性患者,年龄30 ~ 60岁。采用hamd量表对抑郁状态进行分析。采用dexa和化学发光法(ELISA)测定骨密度和内分泌参数。采用spss22软件进行统计相关分析。结果:HAM-D评分与血清皮质醇呈极显著相关(P <0.00001)。HAM-D与BMD的相关性也有统计学意义(P <0.05)。骨密度与血清皮质醇(P?0.05)。血清维生素D与BMD的相关性(P<0.00001)远高于与TSH的相关性(P<0.0001)。讨论与结论:高抑郁水平与低维生素D水平或高血清皮质醇和促甲状腺激素水平相关这是绝经前妇女低骨密度发生继发性骨质疏松症的危险因素可以得出结论,无论具体原因如何,抑郁症患者都应考虑进行骨密度筛查,反之亦然。低骨密度的受试者应考虑在生命早期筛查抑郁症,绝经前妇女应在定期体育活动中补充维生素D,以预防继发性骨质疏松症。
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引用次数: 0
Effect of Short-Term Practice of Bhramari Pranayama on Sleep Quality and Perceived Stress in School Students Bhramari Pranayama短期实践对中学生睡眠质量和压力感知的影响
Pub Date : 2021-01-27 DOI: 10.37506/IJOP.V9I1.2603
Abhishek Kumar, S. Venkatesh
Background: In today’s highly-competitive era of modern education, students are constantly exposedto ‘high’ academic stress. Stress, in turn, affects sleep quality. Deterioration in sleep quality adverselyaffects overall health. Yogic breathing exercise i.e., ‘Pranayama’ practice is an easy yet effective way tomaintain sound physical and mental health. Traditional yogic literatures particularly recommend ‘Bhramari’Pranayama (the ‘Humming Bee’ breath) for effectively reducing stress and improving quality of sleep. Dueto lack of specific scientific evidence to support these benefits from Bhramari Pranayama, this study wasundertaken to evaluate the effect of Bhramari Pranayama practice on sleep quality and perceived stress inschool students.Objectives: To evaluate the effect of short-term (6 weeks) practice of Bhramari Pranayama on Sleep Qualityand Perceived Stress in school students.Methodology: After obtaining Ethical clearance, 60 school students of class X were randomly selected forthe study. Assent from participants and written informed consent from their parents were obtained. Afterhistory-taking and general physical examination, ‘baseline’ data including assessment of Sleep quality andPerceived stress were obtained using the PSQI (Pittsburgh Sleep Quality Index) and PSS (Perceived StressScale) questionnaires respectively. Thereafter, Bhramari Pranayama was practiced by the students for 6weeks. Finally, at the end of 6 weeks sleep quality and perceived stress were re-assessed using the abovequestionnaires. Pre- and post- Bhramari pranayama data were compared and analysed using descriptivestatistics and Student’s t-test; p-value <0.05 was considered as statistically significant.Results: Post Bhramari Pranayama practice, there was significant improvement in Sleep quality & asignificant reduction in Perceived stress (p-value<0.05).Conclusion: Hence, just a few weeks practice of Bhramari Pranayama significantly improves sleep qualityand reduces perceived stress.
背景:在当今竞争激烈的现代教育时代,学生们不断面临“高”的学业压力。压力反过来又会影响睡眠质量。睡眠质量的恶化会对整体健康产生不利影响。瑜伽呼吸练习,即“Pranayama”练习是保持良好身心健康的一种简单而有效的方法。传统瑜伽文献特别推荐“Bhramari”Ranayama(“蜂鸣”呼吸)能有效减轻压力和改善睡眠质量。由于缺乏具体的科学证据来支持Bhramari Pranayama的这些益处,本研究旨在评估Bhramari-Pranayam练习对中学生睡眠质量和感知压力的影响。目的:评估短期(6周)实践Bhramari Pranayama对中学生睡眠质量和压力感知的影响。方法:在获得伦理许可后,随机选择60名X班学生进行研究。获得了参与者的同意和他们父母的书面知情同意。在病史采集和一般体检后,分别使用PSQI(匹兹堡睡眠质量指数)和PSS(感知压力量表)问卷获得包括睡眠质量评估和感知压力在内的“基线”数据。此后,学生们进行了为期6周的Bhramari Pranayama练习。最后,在6周结束时,使用上述问卷重新评估睡眠质量和感知压力。使用描述性统计和Student t检验对Bhramari调息前后的数据进行比较和分析;p值<0.05被认为具有统计学意义。结果:实践Bhramari Pranayama后,睡眠质量显著改善,感知压力显著降低(p值<0.05)。
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引用次数: 2
Effect of Occupational Exposure to Pesticides on Cardiovascular System among Farmers: A Comparative Study 农药职业暴露对农民心血管系统影响的比较研究
Pub Date : 2020-07-22 DOI: 10.37506/ijop.v8i3.1336
M. Sunitha, S. J. Bhoopala, S. Bondade
Background: Agriculturea very complex occupation, apart from increasing productivity also brings huge loss to community in terms of its ill effects on human health,plant and animal life. Adverse effects on cardiovascular system is likely to occur due to aggressive use of agrochemicals such as pesticides. Objectives: To Study Changes in ECG due to pesticide exposure among farmers and to Compare these ECG Changes in those farmers with that of normal non-exposed subjects. Materials and Method: A 12 lead ECG was recorded in apparenty healthy male farmers exposed to pesticides and normal non exposed age matched male control subjects and analysed for parameters such as heart rate, PR interval, QTC interval, QRS axis, ST and T wave changes and compared. Results: This study reports significantly increased heart rate, prolonged QTC interval and non-specific ST and T wave changes among pesticide exposed farmers compared to non-exposed control subjects. Conclusion: The current study concludes that there is a need to detect these ECG changes as early as possible so that future risk of cardiovascular disease can be prevented by adapting precautionary measures during application of pesticides. Some form of continuous cardiac monitoring seems advisable. Farmers can be advised to quit toxic chemical fertilizers & pesticides and opt Organic ones to be safe from the hazardous implications of exposure.
背景:农业是一个非常复杂的职业,在提高生产力的同时也给社区带来了巨大的损失,因为它对人类健康、植物和动物的生命产生了不良影响。大量使用农药等农用化学品可能对心血管系统产生不良影响。目的:研究农药暴露对农民心电图的影响,并与未接触农药的正常人群进行比较。材料与方法:记录农药暴露后表面健康的男性农民与正常未暴露年龄相匹配的男性对照者12导联心电图,分析心率、PR间期、QTC间期、QRS轴、ST、T波变化等参数,并进行比较。结果:本研究报告了农药暴露农民与未暴露对照组相比,心率显著增加,QTC间隔延长,ST波和T波非特异性变化。结论:目前的研究表明,有必要尽早检测这些心电图变化,以便在施用农药时采取预防措施,预防未来心血管疾病的风险。某种形式的持续心脏监测似乎是可取的。可以建议农民放弃使用有毒的化学肥料和农药,选择有机肥料,以避免接触有害的影响。
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引用次数: 0
Correlation of Changes of Blood Pressure and Intra Ocular Pressure After Isometric Handgrip Exercise Test in Young Adults 青年人等长握力运动试验后血压和眼压变化的相关性研究
Pub Date : 2020-07-22 DOI: 10.37506/IJOP.V8I3.1332
P. Rao, H. A. Chethan
Objective: To correlate the blood pressure changes to intraocular pressure before and after Handgrip exercise Method: Healthy young male adults in the age group of 18-22 years were selected among general population. Sample size was 40. Heart rate and intra ocular pressure (IOP) were recorded at rest and after isometric Handgrip test Results: Handgrip predictably raised Systolic blood pressure has increased significantly from resting of 113.40±5.75 to 133.50±4.29 (p<0.001) immediately after Handgrip exercise SBP has returned back to resting level within 10 min after exercise. Diastolic blood pressure has increased from significantly from resting of 72.45±4.37 to 89.95±3.28 p<0.001) immediately after Handgrip IOP has returned back to baseline level within 10 min after exercise (p-0.001- sig). Right eye IOP has decreased significantly from resting 16.27±1.54 to 13.34±1.32 (p<0.001) after handgrip exercise. Left eye IOP has decreased significantly from resting 16.28±1.55 to 13.04±1.19 (p<0.001)immediately after handgrip exercise;p<0.05). Blood Pressure is significantly and negatively correlated with IOP (Pearson’s correlation coefficient, r = -0.352). Conclusion: Isometric Handgrip exercise induces raise in blood pressure and simultaneously lowers IOP which were significant. Hence may prove useful in normotensive glaucomatous patients
目的:探讨握力运动前后血压变化与眼压的关系。方法:在普通人群中选择年龄在18 ~ 22岁的健康青年男性。样本量为40。结果:握力可预测地提高收缩压,从静止时的113.40±5.75显著增加到133.50±4.29 (p<0.001)。握力运动后,收缩压在运动后10分钟内恢复到静止水平。Handgrip IOP在运动后10分钟内恢复到基线水平后,舒张压从静止时的72.45±4.37显著增加到89.95±3.28 (p <0.001)。握力训练后右眼IOP由静止时的16.27±1.54下降至13.34±1.32 (p<0.001)。左眼IOP由静息时的16.28±1.55显著下降到握力训练后的13.04±1.19 (p<0.001), p<0.05)。血压与IOP呈显著负相关(Pearson相关系数r = -0.352)。结论:等长握力运动可引起血压升高,同时降低眼压。因此可能对正常血压青光眼患者有用
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引用次数: 0
The Comparative Study on Stress of Medical and Engineering Students by Using Kessler’s k-10 Questionnaire 应用Kessler k-10量表对医工科学生压力状况的比较研究
Pub Date : 2020-04-29 DOI: 10.37506/IJOP.V8I2.1235
A. P. Kulkarni, R. Rohilla, B. Reddy, J. Behera
Context: Many studies in medical students show that they experience a high level of stress in Undergraduatecourse(1,2,3,4,5). This high level of stress has detrimental effect on learning and cognitive functioning ofstudents(6).Aim: To determine the level of stress in medical and engineering students using K 10 questionnaire.Results: The response rate of students for questionnaire was 85.6%. High prevalence of stress was noted(experienced both by male and female) in medical compared with engineering students. Stress levels werehigher in first year and final year among medical students. Stress level subsided as the year of study inprofessional course progressed.Conclusion: Stress was found in both medical and engineering students with higher stress levels in femalesas compared to males. There is a pressing need to teach students to handle stress.
背景:许多针对医学生的研究表明,他们在本科生课程中经历了高水平的压力(1,2,3,4,5)。这种高水平的压力对学生的学习和认知功能有不利影响(6)。目的:采用K 10量表测定医学与工程专业学生的压力水平。结果:学生对问卷的回答率为85.6%。与工科学生相比,医学生的压力发生率较高(男性和女性都有)。医学生的压力水平在第一年和最后一年更高。随着专业课程学习的进行,压力水平逐渐降低。结论:医学和工程专业的学生都存在压力,女性的压力水平高于男性。迫切需要教会学生如何处理压力。
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引用次数: 0
Impact of Duration of Smoking on Lung Function Parameters in Young Adult Males 吸烟时间对青年男性肺功能参数的影响
Pub Date : 2020-04-29 DOI: 10.37506/IJOP.V8I2.1236
M. ChandrashekharD, Anandkumar, K. JayalakshmiM, P. Babu
Background: The tobacco epidemic is one of the biggest public health threats the world has ever faced,killing more than 8 million people a year. In 2002, about 20% of young teens smoked worldwide, half ofthose who begin smoking in adolescent years are projected to go on to smoke for 15 to 20 years. Smokingincreases the risk of developing coronary artery disease, stroke, chronic obstructive pulmonary disease(COPD) and various malignancies. Smoking is being recognized as the most important causative factor forCOPD. While studies have shown an overall ‘dose response curve” for smoking and lung function, someindividuals develop severe disease within few years of smoking, whereas some individuals show minimalto no clinical symptoms even after many years of smoking. Hence the following cross sectional study wasundertaken to assess the extent of decline in lung function parameters with duration of smoking in youngadults with no apparent clinical features of COPD.Objectives: To assess the impact of duration of smoking on various lung function parameters in young adultmales.Materials and Method: Fifty apparently healthy, young smokers were selected for the study. Pulmonaryfunction test was evaluated by computerized spirometer (UNI-EM SPIROMIN). Correlation betweenduration of smoking and various lung function parameters was analyzed by ANNOVA.Results: All parameters were found to decline with duration of smoking, however the decline in FVC andFEV1 were statistically significant.Conclusion: Duration of smoking is correlated strongly with decline in FVC and FEV1 values.
背景:烟草流行是世界有史以来面临的最大公共卫生威胁之一,每年造成800多万人死亡。2002年,全世界约有20%的青少年吸烟,其中一半在青少年时期开始吸烟,预计将持续吸烟15至20年。吸烟会增加患冠状动脉疾病、中风、慢性阻塞性肺病(COPD)和各种恶性肿瘤的风险。吸烟被认为是COPD最重要的致病因素。虽然研究表明吸烟和肺功能的总体“剂量-反应曲线”,但有些人在吸烟几年内就会患上严重疾病,而有些人即使在吸烟多年后也表现出最低程度的临床症状。因此,进行了以下横断面研究,以评估没有明显COPD临床特征的年轻人的肺功能参数随吸烟时间的下降程度。目的:评估吸烟时间对青年成年男性各种肺功能参数的影响。材料和方法:选择50名明显健康的年轻吸烟者进行研究。肺功能测试采用计算机肺活量计(UNI-EM SPIROMIN)进行评估。用ANNOVA分析吸烟时间与各种肺功能参数之间的相关性。结果:所有参数均随吸烟时间的延长而下降,但FVC和FEV1的下降具有统计学意义。结论:吸烟时间与FVC和FEV1值的下降密切相关。
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引用次数: 1
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International journal of physiology
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