Lattice strain engineering has emerged as a powerful and versatile strategy for modulating the electronic and geometric structures of electrocatalysts at the atomic scale. By finely tuning interatomic distances and orbital interactions, lattice strain directly influences adsorption energetics and reaction kinetics, offering an effective pathway to overcome intrinsic activity and stability limitations in key electrochemical processes. This review systematically summarizes the fundamental principles of lattice strain effects, including electronic and geometric modulation mechanisms and their correlation with the d-band center theory. We highlight the main approaches for strain induction, such as orbital symmetry matching, antibonding state occupancy, charge redistribution, and adsorbate-induced surface relaxation. We further summarize quantitative relationships between strain and catalytic activity, including volcano plots, strain-ΔG* correlations, and strain-TOF dependencies, distinguishing between compressive and tensile strain effects across various reactions such as HER, OER, ORR, CO2RR, and NRR. Special attention is given to how controlled strain optimizes intermediate adsorption energies in accordance with the Sabatier principle, thereby enhancing catalytic activity, selectivity, and durability. Finally, we discuss the remaining challenges in controlling strain magnitude, stability, and scalability, and outline perspectives for integrating strain engineering with other design principles. This review establishes lattice strain as a unifying and predictive framework for rational catalyst design, paving the way for high-performance electrocatalysts in sustainable energy conversion and storage technologies.
Organic nanoparticles can play an integral role in the biomedical field by optimizing the medication process in cancer treatment. They can ensure the non-toxic and target-specific delivery of a cancer-based antigen. Compared to conventional strategies, the microfluidic approach can ensure reproducible organic nanoparticles. The microfluidic approach can ensure the utmost controllability over reaction parameters and mixing performance. In this way, scientists can secure organic nanoparticles with a narrow size distribution and mono-dispersion. The microfluidic approach offers the chance for health scientists to secure industrial-scale productivity of organic nanoparticles. This review summarizes recent advancements in microfluidics for the synthesis of organic nanoparticles with relevant specifications. We emphasize the key fundamentals and the advantages of next-generation microfluidics over conventional strategies for the preparation of organic nanoparticles. Some positive and negative prospects that can affect the structural morphology and delivery of organic nanoparticles are highlighted. The developments in cancer-based therapies and administration routes via organic nanoparticles are also discussed briefly.

