Archivos de la Sociedad Espanola de Oftalmologia最新文献

英文中文

Pigmentary dispersion syndrome and pigmentary glaucoma: Diagnostic relevance of the classical triad in a Mediterranean population 色素性色散综合征和色素性青光眼：地中海人群经典三联征的诊断相关性。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-08-23 DOI: 10.1016/j.oftale.2025.08.007

J. Benitez-del-Castillo , M. Villalba-Conde , V. Amaya-López , M.D. Pinazo-Duran

Introduction and objectives

To assess prevalence of classic clinical signs of Pigment Dispersion Syndrome (PDS) in PDS and Pigmentary Glaucoma (PG) in caucasian patients from Southern Spain.

Materials and methods

Cross-sectional observational case-series study evaluating the prevalence of characteristic clinical signs of PDS: Krukenberg spindle (KS), Trabecular meshwork pigmentation (TMP) and Iris transillumination defects (ITD). Differences between PDS and PG patients are evaluated and the probability of association with PG of clinical signs with statistically significant differences is also calculated (Odds Ratio OR in logistic regression analysis).

Results

144 PDS/PG patients. Prevalence of KS, TMP and ITD is 91%, 88.9% and 24.3%. 48 right eyes (66.7%) were PDS and 24 right eyes (33.3%) were considered PG patients. Prevalence of KS is 95.8% in PDS and 91.7% in PG (p = 0.47). Prevalence of TMP is 87.5% in PDS and 95.8% in PG (p = 0.26). Prevalence of ITD is 16.7% in PDS and 41.7% in PG (p = 0.02). OR of those presenting PG is 3.57 for ITD (95% CI 1.17 to 10.85) (p = 0.02).

Conclusions

There are no major differences in the prevalence of KS and TMP in our population of patients with PDS/PG compared to published data in the Caucasian population (91% vs 95% for KS and 88.9% vs 86% for TMP) but there are differences in the prevalence of ITD (24.3% vs 86%).

简介和目的：评估西班牙南部高加索患者色素弥散综合征（PDS）和色素性青光眼（PG）中典型临床体征的患病率。材料和方法：横断面观察性病例系列研究评估PDS特征性临床体征的患病率：Krukenberg纺锤体（KS）、小梁网色素沉着（TMP）和虹膜透射缺陷（ITD）。评估PDS与PG患者之间的差异，并计算有统计学差异的临床体征与PG相关的概率（logistic回归分析中的Odds Ratio OR）。结果：144例PDS/PG患者。KS、TMP和ITD患病率分别为91%、88.9%和24.3%。48只右眼（66.7%）为PDS， 24只右眼（33.3%）为PG。PDS患者KS患病率为95.8%，PG患者为91.7% （p = 0.47）。PDS患者TMP患病率为87.5%，PG患者为95.8% （p = 0.26）。PDS的ITD患病率为16.7%，PG为41.7% （p = 0.02）。ITD患者PG的OR为3.57 (95% CI 1.17 ~ 10.85) （p = 0.02）。结论：与已发表的高加索人群数据相比，PDS/PG患者中KS和TMP的患病率没有重大差异（KS为91%对95%，TMP为88.9%对86%），但ITD的患病率存在差异（24.3%对86%）。

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引用次数: 0

AMBISiON-IMPaCT: A project to enrich the IMPaCT cohort with eye health measures for precision medicine 雄心-影响：这是一个项目，旨在为精准医疗提供眼科健康措施，以丰富IMPaCT队列。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-10-20 DOI: 10.1016/j.oftale.2025.10.010

E. García-Esquinas , M.J. Sánchez , J.J. González-López , F. Rodríguez-Artalejo , B. Pérez-Gómez , on behalf of all AMBISiON-IMPaCT project investigators

引用次数: 0

Relevance of ‘popcorn’ discovery in retinopathy of premature “爆米花”发现与早产儿视网膜病变的相关性。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-09-20 DOI: 10.1016/j.oftale.2025.09.007

E. Gracia-Rovira, A. Díaz Barrón, A.M. Duch Samper

引用次数: 0

Ophthalmologic findings in a patient with methylmalonic acidemia and the N219Y mutase mutation 甲基丙二酸血症和N219Y突变患者的眼科检查结果。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-10-14 DOI: 10.1016/j.oftale.2025.10.004

Mark Rabinovich , Kristof Vandekerckhove , Adrian Gericke

We document the clinical ocular presentation of methylmalonic acidemia (MMA) with a mutase defect, specifically the MUT N219Y variant, in a 27-year-old female who presented with sudden bilateral visual acuity deterioration. The ophthalmologic workup included visual acuity testing, biomicroscopic and fundus examinations, macular spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence, multicolor imaging, retinal nerve fiber layer analysis, kinetic and static visual field testing, and head magnetic resonance imaging. The patient demonstrated bilateral visual acuity loss, more severe in the left eye. SD-OCT of the macula and optic nerve appeared normal, yet static visual field testing showed elevated central threshold values bilaterally, and kinetic testing revealed bilateral constriction. MRI of the head revealed bilateral focal signal abnormalities of the optic nerves, with left-sided predominance. This case represents the first detailed ophthalmologic description in a patient with MMA carrying the MUT N219Y variant.

我们记录了一位27岁女性的临床眼部表现，甲基丙二酸血症（MMA）伴有突变酶缺陷，特别是MUT N219Y变异，她表现为突然的双侧视力恶化。眼科检查包括视力检查、生物显微镜和眼底检查、黄斑光谱域光学相干断层扫描（SD-OCT）、眼底自身荧光、多色成像、视网膜神经纤维层析、动态和静态视野测试、头部磁共振成像。患者表现为双侧视力丧失，左眼更为严重。黄斑和视神经SD-OCT显示正常，但静态视野测试显示双侧中枢阈值升高，动力学测试显示双侧缩窄。头部MRI显示双侧视神经局灶性信号异常，以左侧为主。该病例代表了携带MUT N219Y变异的MMA患者的第一个详细的眼科描述。

引用次数: 0

30-Gauge needle Descemet membrane endothelial keratoplasty graft obtention: A novel, safer and cheap technique 30针角膜内皮膜移植术：一种新颖、安全、廉价的技术。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-09-27 DOI: 10.1016/j.oftale.2025.09.011

P. Pérez-García , J.A. Gegúndez-Fernández , M. Ariño-Gutiérrez , M. Molero-Senosiaín , B. Burgos-Blasco , D. Díaz-Valle

This work aims to present a novel technique for obtaining grafts for Descemet Membrane Endothelial Keratoplasty (DMEK) safely and efficiently, thanks to its fast learning curve and reduced risk of graft tears. The technique involves the peripheral dissection of the endothelium starting with a superficial incision made using a 30-Gauge needle, 1 mm inside Schwalbe's line across 360º of the corneal periphery. Trypan Blue is then applied to visualize the dissection boundary, and a DMEK Sinskey hook is used to lift 1 mm of the peripheral graft along the entire circumference. The technique continues with the separation of Descemet's membrane from the stroma, as is commonly performed. This technique reduces costs by employing a standard needle and achieves low failure rates compared to other techniques.

这项工作的目的是提出一种新的技术，安全有效地获得移植物的Descemet膜内皮角膜移植术（DMEK），由于其快速的学习曲线和降低移植物撕裂的风险。该技术涉及到内皮细胞的周围剥离，首先使用30号针在角膜周围360度的施瓦尔贝线内1毫米处做一个浅表切口。然后应用台盼蓝显示解剖边界，并使用DMEK Sinskey钩沿整个周长提起1mm外周移植物。该技术继续将Descemet的膜从基质中分离出来，这是通常的做法。与其他技术相比，该技术通过使用标准针头降低了成本，故障率低。

引用次数: 0

Analysis of factors associated with post-vitrectomy cataract formation in phakic patients undergoing vitrectomy for rhegmatogenous retinal detachment 玻璃体切除术后孔源性视网膜脱离白内障形成的相关因素分析。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-09-05 DOI: 10.1016/j.oftale.2025.09.004

A. Gibelalde, S. Pinar-Sueiro, I. Martínez-Soroa

Introductions and objectives

This study assesses risk factors for developing cataracts after vitrectomy with tamponade for rhegmatogenous retinal detachment (RRD) in phakic patients and explores the potencial causal relationship between RRD surgery and the development of cataracts.

Materials and methods

This was a retrospective study analysing the medical records of patients undergoing RRD surgery between 2012 and 2020 (9 years) at Donostia University Hospital (HUD). We collected data on the date of phacoemulsification surgery after vitrectomy surgery for RRD, as well as the type of vitrectomy and patient characteristics.

Results

Patients who underwent cataract surgery were on average older (mean age of 60.79 years old ± 9.49) than those who did not undergo this type of surgery during follow-up (52.97 years old ± 13.59), the difference being statistically significant (0P < .0001). Classifying patients by age at the date of the vitrectomy (≤50 years or >50 years of age), we found between-group differences in phacoemulsification rates after vitrectomy in the follow-up period, cataract surgery being performed in a third of the younger group and three-quarters of the older group (P < .0001).

Conclusions

Patients with phakic RRD under 50 years old have a lower risk of cataract development after vitrectomy with tamponade than those over 50 years old. The use of long-acting tamponade gases such as C3F8 and silicone oil in phakic patients seems to increase the likelihood of needing early cataract surgery after RRD surgery with PPV.

前言和目的：本研究评估晶状体切除术合并填塞治疗孔源性视网膜脱离（RRD）后白内障发生的危险因素，探讨RRD手术与白内障发生之间的潜在因果关系。材料和方法：这是一项回顾性研究，分析了2012年至2020年（9年）在多诺斯蒂亚大学医院（HUD）接受RRD手术的患者的医疗记录。我们收集了RRD玻璃体切除术后超声乳化手术的资料，以及玻璃体切除术的类型和患者的特征。结果：随访期间，行白内障手术的患者平均年龄（平均年龄60.79±9.49岁）大于未行白内障手术的患者（平均年龄52.97±13.59岁），差异有统计学意义（p < 50岁）；随访期间，玻璃体切除术后的超声乳化率组间差异较大（p < 50岁），年轻组有三分之一的患者行白内障手术，老年组有四分之三的患者行白内障手术（p < 50岁）。年龄在50岁以下的晶状体白内障患者在玻璃体切除合并填塞后发生白内障的风险低于年龄在50岁以上的患者。在有晶状体的患者中使用长效填塞气体，如C3F8和硅油，似乎增加了在有PPV的RRD手术后需要早期白内障手术的可能性。

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引用次数: 0

Should XYY syndrome be considered in the differential diagnosis of syndromic myopia? Apropos of a case 在辨证性近视时是否应考虑XYY综合征？关于一个案子。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-08-06 DOI: 10.1016/j.oftale.2025.08.005

R. Morales-Reyes , L.A. Garza-Garza , R.A. Villafuerte-de la Cruz , M. Garza-Leon

Introduction and objectives

XYY syndrome is relatively common and misdiagnosed. In addition high myopia appears to be more frequent in this syndrome than in the general population. Therefore, the objective of the present report is to emphasize the association of XYY syndrome and high myopia.

Materials and methods

Case report of a single patient.

Results

An 8-year-old male patient with a history of XYY syndrome was examined. Physical examination revealed tall stature, low-set auricular pavilion implantation, mid-face hypoplasia, horizontal palpebral fissures. Ophthalmological evaluation showed early-onset high myopia in both eyes and a complete nuclear cataract and chronic retinal detachment in the right eye.

Discussion

Patients with XYY syndrome appear to exhibit a high prevalence of myopia. Although the pathophysiology of myopia in patients with XYY syndrome is not yet fully understood, it should be considered as a differential diagnosis for syndromic myopia.

简介与目的：XYY综合征是一种较为常见且易误诊的疾病。此外，高度近视在这种综合征中似乎比在一般人群中更常见。因此，本报告的目的是强调XYY综合征与高度近视的关系。材料与方法：1例病例报告。结果：我们检查了一名有XYY综合征病史的8岁男性患者。体格检查：身高高，耳亭植入位置低，中脸发育不全，睑裂水平。眼科检查显示双眼早发性高度近视，右眼完全性核性白内障及慢性视网膜脱离。讨论：XYY综合征患者似乎表现出高度流行的近视。虽然XYY综合征患者近视的病理生理尚不完全清楚，但应将其作为综合征性近视的鉴别诊断。

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引用次数: 0

Comparison of 2 swept-source optical biometers: IOLMaster 700 vs. Revo FC 130 两种扫描源光学生物计的比较：IOLMaster 700与Revo FC 130。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-09-05 DOI: 10.1016/j.oftale.2025.09.002

A. Ortiz , E. García , J. Ortega , J. de Vera , E. Vázquez , M. Carrillo , V. Romero , K. Merizalde

Objective

To evaluate the measurement accuracy of 2 swept-source optical biometers, the IOLMaster 700 and the Revo FC 130, in patients diagnosed with cataracts.

Methods

We conducted a prospective, observational and comparative study in patients older than 40 years with cataracts. A single operator performed optical biometry using both devices during the same session. Cataract grading was conducted using the Lens Opacities Classification System III.

Results

Biometric measurements were obtained from the 504 eyes of 279 patients, with a mean age of 70.93 ± 8.41 years. Statistically significant differences were found between the IOLMaster 700 and Revo FC 130 in the following parameters: mean keratometry (43.53 ± 1.56 vs 44.27 ± 1.68 diopters), total average keratometry and mean keratometry (43.56 ± 1.55 D vs 44.27 ± 1.67 diopters), white-to-white distance (11.98 ± 0.52 vs 12.66 ± 0.73 mm), and lens thickness (4.53 ± 0.40 vs 4.60 ± 0.40 mm). No significant differences were found in axial length (23.31 ± 0.96 vs 23.25 ± 1.01 mm) or anterior chamber depth (3.02 ± 0.38 vs 3.02 ± 0.37 mm), which were not clinically relevant. No statistically significant differences were found between the IOLMaster 700 measurements of total mean keratometry (43.53 ± 1.56 diopters) and mean keratometry (43.56 ± 1.56 diopters).

Conclusions

Although most measurements do not reveal any clinically relevant differences, the 2 devices should not be used interchangeably, mainly due to variations in keratometry readings.

目的：评价两种扫描源光学生物计IOLMaster 700和Revo FC 130在白内障患者中的测量精度。方法：我们对40岁以上白内障患者进行了一项前瞻性、观察性和比较研究。一名操作员在同一会话期间使用两种设备进行光学生物测定。采用晶状体混浊分级系统III进行白内障分级。结果279例患者504只眼获得生物特征测量，平均年龄70.93±8.41岁。IOLMaster 700与Revo FC 130在以下参数上差异有统计学意义：平均角膜屈光度（43.53±1.56 vs 44.27±1.68）、总平均角膜屈光度与平均角膜屈光度（43.56±1.55 D vs 44.27±1.67）、白-白距离（11.98±0.52 vs 12.66±0.73 mm）、晶状体厚度（4.53±0.40 vs 4.60±0.40 mm）。轴长（23.31±0.96 vs 23.25±1.01 mm）和前房深度（3.02±0.38 vs 3.02±0.37 mm）差异无统计学意义，无临床意义。IOLMaster 700测量的总平均角膜屈光度（43.53±1.56屈光度）与平均角膜屈光度（43.56±1.56屈光度）无统计学差异。结论：虽然大多数测量结果没有显示任何临床相关差异，但这两种设备不应互换使用，主要是由于角膜测量读数的差异。

{"title":"Comparison of 2 swept-source optical biometers: IOLMaster 700 vs. Revo FC 130","authors":"A. Ortiz , E. García , J. Ortega , J. de Vera , E. Vázquez , M. Carrillo , V. Romero , K. Merizalde","doi":"10.1016/j.oftale.2025.09.002","DOIUrl":"10.1016/j.oftale.2025.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the measurement accuracy of 2 swept-source optical biometers, the IOLMaster 700 and the Revo FC 130, in patients diagnosed with cataracts.</div></div><div><h3>Methods</h3><div>We conducted a prospective, observational and comparative study in patients older than 40 years with cataracts. A single operator performed optical biometry using both devices during the same session. Cataract grading was conducted using the Lens Opacities Classification System III.</div></div><div><h3>Results</h3><div>Biometric measurements were obtained from the 504 eyes of 279 patients, with a mean age of 70.93 ± 8.41 years. Statistically significant differences were found between the IOLMaster 700 and Revo FC 130 in the following parameters: mean keratometry (43.53 ± 1.56 vs 44.27 ± 1.68 diopters), total average keratometry and mean keratometry (43.56 ± 1.55 D vs 44.27 ± 1.67 diopters), white-to-white distance (11.98 ± 0.52 vs 12.66 ± 0.73 mm), and lens thickness (4.53 ± 0.40 vs 4.60 ± 0.40 mm). No significant differences were found in axial length (23.31 ± 0.96 vs 23.25 ± 1.01 mm) or anterior chamber depth (3.02 ± 0.38 vs 3.02 ± 0.37 mm), which were not clinically relevant. No statistically significant differences were found between the IOLMaster 700 measurements of total mean keratometry (43.53 ± 1.56 diopters) and mean keratometry (43.56 ± 1.56 diopters).</div></div><div><h3>Conclusions</h3><div>Although most measurements do not reveal any clinically relevant differences, the 2 devices should not be used interchangeably, mainly due to variations in keratometry readings.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 11","pages":"Pages 658-665"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravitreal Fluocinolone Acetonide Implant (ILUVIEN®) for the treatment of ocular juvenile xanthogranuloma 玻璃体内氟西诺酮醋酸酯植入物（ILUVIEN®）治疗幼年性眼黄色肉芽肿。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-08-06 DOI: 10.1016/j.oftale.2025.08.002

M. Larrañaga Cores , M. Asencio Durán , J. Peralta Calvo , M. Feito Rodríguez , G. Amorena Santesteban , A. del Hierro Zarzuelo , A. Boto-de-los-Bueis

This is the case of a 14-years-old woman referred to our ophthalmology department with suspected iris juvenile xanthogranuloma, with reported bilateral, hematic recurrent uveitis as soon as she discontinued treatment with topical prednisolone acetate eye drops. After numerous treatments at the 3-year follow-up, including oral steroids, repeated injections of subtenon triamcinolone acetonide and intracameral and intravitreal anti-VEGF, treatment with intravitreal fluocinolone acetonide implant (ILUVIEN®) in both eyes was decided. Evolution since then and at the 10-month follow-up has been satisfactory; the patient has not exhibited any new episodes of ocular inflammation or hyphema despite the progressive withdrawal of topical corticosteroids, and vision has remained at 20/20 in both eyes. As far as we know, this is the first case of bilateral ocular juvenile xanthogranuloma successfully treated with an intravitreal fluocinolone implant.

这是一名14岁的女性，因疑似虹膜幼年黄色肉芽肿而转诊至我们的眼科，她在停止使用醋酸泼尼松龙眼药水治疗后立即报告双侧出血性复发性葡萄膜炎。经过3年随访期间的多次治疗，包括口服类固醇、反复注射曲安奈德次坦、眼内和玻璃体内抗vegf，最终决定双眼使用玻璃体内醋酸氟西诺酮种植体（ILUVIEN®）治疗。此后和10个月随访的进展令人满意；尽管局部皮质类固醇逐渐停用，但患者未出现任何新的眼部炎症或前房积血发作，双眼视力保持在20/20。据我们所知，这是首例通过玻璃体内氟西诺酮植入成功治疗双侧幼年性眼黄色肉芽肿的病例。

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引用次数: 0

Retinal detachment associated to macular hole in nanophthalmos and high hyperopia 纳米眼和高度远视与黄斑孔相关的视网膜脱离。

Archivos de la Sociedad Espanola de Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-08-06 DOI: 10.1016/j.oftale.2025.08.004

A.L. Quiroz, P. Armendariz, J.D. Grigera

We report the case of a 74-year-old woman with high hyperopia and nanophthalmos who presented with a progressive central scotoma in her left eye. Best-corrected visual acuity was limited to hand motion, and examination revealed a full-thickness macular hole associated with retinal detachment. Pars plana vitrectomy with the inverted internal limiting membrane (ILM) flap technique and 20% sulfur hexafluoride (SF6) tamponade was performed, but hole closure was not achieved. A second surgery including phacovitrectomy, retinal massage and ILM flap repositioning resulted in successful anatomical closure and visual improvement. This case highlights the value of adjunctive techniques such as retinal massage and accurate ILM flap repositioning to promote closure in complex and uncommon scenarios.

我们报告的情况下，74岁的妇女高度远视和纳米眼谁提出了进行性中央暗斑在她的左眼。最佳矫正视力仅限于手部运动，检查发现全层黄斑孔伴视网膜脱离。采用倒内限制膜（ILM）皮瓣技术和20%六氟化硫（SF6）填塞术行玻璃体平面肌切除术，但未达到闭眼效果。第二次手术包括晶状体切除术，视网膜按摩和ILM瓣重新定位，成功地闭合了解剖和改善了视力。本病例强调了辅助技术的价值，如视网膜按摩和准确的ILM瓣重新定位，以促进复杂和罕见情况下的闭合。

引用次数: 0

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