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One-year outcomes by index treatment in older patients with acute cholecystitis. Protocol of the international, prospective, observational GOLDENEYE study. 老年急性胆囊炎患者指数治疗的1年预后。国际前瞻性观察性GOLDENEYE研究方案。
Pub Date : 2025-12-23 DOI: 10.1016/j.cireng.2025.800282
Núria Lluís, Sara Pérez-Brotons, Isabel de Castro, Belén Martínez, José R Aparicio, Pedro Zapater, Fèlix Lluís, Enrique de-Madaria

Background: This research project is motivated by the increasing prevalence of gallstones and biliary tract diseases in patients of advanced age, while also recognizing that the comorbidity burden of this population may necessitate a tailored treatment approach. Acute cholecystitis can rapidly progress to systemic inflammatory response syndrome, sepsis and even death. Age per se has no bearing on the severity of acute cholecystitis, but the burden of comorbidity in older patients may lead to rapid disease progression.

Methods: The GOLDENEYE study is an international, multicenter, prospective, observational research project designed to compare the outcomes of different management strategies for acute cholecystitis in seniors. The primary aims are to evaluate the efficacy of different treatments-supportive care, percutaneous gallbladder drainage, early or delayed cholecystectomy, and EUS-guided gallbladder drainage-on one-year additional treatment modalities, hospital readmissions, and outpatient care. Secondary outcomes are quality of life and survival rates. The study implements propensity score matching analysis to account for the non-randomized allocation of treatment modalities. Patients ≥ 70 years diagnosed with acute cholecystitis, as per the Tokyo guidelines, are included. Exclusion criteria include prior episodes of cholecystitis or pancreatitis, terminal illness, and concurrent diagnosis of acute pancreatitis, cholangitis, bile duct disease, or digestive malignancy. Data collection is performed with the REDCap platform for data entry and monitoring.

Discussion: The GOLDENEYE study aims to generate evidence-based insights that will significantly influence the management of acute cholecystitis in elderly patients, ultimately improving patient outcomes and healthcare practices in this growing demographic population.

Clinicaltrials: gov, NCT07006298.

背景:该研究项目的动机是由于胆结石和胆道疾病在老年患者中的患病率日益增加,同时也认识到这一人群的合并症负担可能需要量身定制的治疗方法。急性胆囊炎可迅速发展为全身炎症反应综合征、败血症甚至死亡。年龄本身与急性胆囊炎的严重程度无关,但老年患者的合并症负担可能导致疾病快速进展。方法:GOLDENEYE研究是一项国际、多中心、前瞻性、观察性研究项目,旨在比较老年人急性胆囊炎不同治疗策略的结果。主要目的是评估不同治疗方法(支持治疗、经皮胆囊引流、早期或延迟胆囊切除术和eus引导下的胆囊引流)对1年额外治疗方式、再入院和门诊治疗的疗效。次要结果是生活质量和生存率。本研究采用倾向评分匹配分析来解释治疗方式的非随机分配。根据东京指南,≥70岁诊断为急性胆囊炎的患者也包括在内。排除标准包括既往胆囊炎或胰腺炎发作、绝症、急性胰腺炎、胆管炎、胆管疾病或消化道恶性肿瘤的并发诊断。数据收集是通过REDCap平台进行数据输入和监控的。讨论:GOLDENEYE研究旨在产生基于证据的见解,这将显著影响老年患者急性胆囊炎的管理,最终改善患者的预后和医疗保健实践。临床试验:政府,NCT07006298。
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引用次数: 0
Information systems in surgery: How do I obtain the data I need? Confidentiality and data protection. 外科信息系统:我如何获得我需要的数据?保密和数据保护。
Pub Date : 2025-12-17 DOI: 10.1016/j.cireng.2025.800265
Francisco Miguel González Valverde
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引用次数: 0
The importance of establishing and monitoring quality objectives and indicators. 建立和监控质量目标和指标的重要性。
Pub Date : 2025-12-17 DOI: 10.1016/j.cireng.2025.800266
Ana Rodríguez-Sánchez, Ramón Moreno Balsalobre
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引用次数: 0
Real robotic approach for left hepatectomy with en bloc caudatectomy and portal vein resection for Bismuth IIIb hilar cholangiocarcinoma. 真正的机器人入路治疗Bismuth IIIb肝门部胆管癌的左肝整体尾状切除术和门静脉切除术。
Pub Date : 2025-12-13 DOI: 10.1016/j.cireng.2025.800267
Jordi Navinés-López, Alba Zárate Pinedo, Francisco Espin Alvarez, Esteban Cugat Andorrà

This article provides a detailed description of the robotic approach used to perform an extended left hepatectomy with venous resection in a 65-year-old female patient with a Bismuth-Corlette tumour type 3b infiltrating the portal confluence. A Glissonean pedicle approach was used to achieve total prehepatic vascular control and resection of the left portal confluence, followed by transverse reconstruction according to the Heineke-Mikulicz technique. The parenchymal transection, including the entire caudate lobe, was performed robotically, with left hanging manoeuvre after complete piggybacking of the vena cava. The final pathological result was G3 pT2bN1M0 (2/11) signet ring cell adenocarcinoma. The robotic approach enabled adjuvant treatment to be initiated immediately. No major complications were recorded within 90 days, and the patient was discharged on the 5th day.

这篇文章详细描述了机器人入路对一名浸润门静脉汇合处的3b型Bismuth-Corlette肿瘤的65岁女性患者进行扩展左肝切除术并静脉切除。采用Glissonean椎弓根入路控制肝前血管并切除左门静脉汇合处,然后根据Heineke-Mikulicz技术进行横向重建。包括整个尾状叶在内的实质横断是机器人完成的,在完全背靠腔静脉后采用左悬挂操作。最终病理结果为G3 pT2bN1M0(2/11)印戒细胞腺癌。机器人方法可以立即开始辅助治疗。90天内无重大并发症记录,第5天出院。
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引用次数: 0
A stepwise approach to totally robotic pancreas-sparing duodenectomy with intracorporeal duodenojejunostomy. 全机器人保留胰腺十二指肠切除术与十二指肠空肠内吻合术的逐步方法。
Pub Date : 2025-12-11 DOI: 10.1016/j.cireng.2025.800273
Giuseppe Serena, Naib Chowdhury, Gary Bernard Deutsch, Sandeep Anantha Sathyanarayana

While pancreaticoduodenectomy is the standard for duodenal malignancy, pancreas-sparing duodenectomy (PSD) is a surgical option for benign duodenal disease. Robotic surgery for PSD offers advantages, such as enhanced visualization, improved instrument dexterity, and optimized dissection, while maintaining resection quality. After preoperative imaging review, we performed a totally robotic PSD with intracorporeal duodenojejunostomy in a 70-year-old patient with a 2.2-cm sessile polyp and dysplasia in the D3 portion of the duodenum. Although PSD is not indicated for malignancy, a negative intraoperative frozen section is critical before proceeding in select cases. A key learning point is combining robotic visualization with upper endoscopy to accurately define the distance between the ampulla and the lesion, ensuring oncologic margins. This manuscript outlines a stepwise surgical approach in a technically challenging scenario, aiming to preserve patient safety and provide an oncologically sound resection using totally robotic techniques.

胰十二指肠切除术是十二指肠恶性肿瘤的标准手术,保留胰十二指肠切除术(PSD)是良性十二指肠疾病的手术选择。机器人手术为PSD提供了优势,如增强可视化,提高器械灵活性,优化解剖,同时保持切除质量。在术前影像学检查后,我们对一名70岁的患者进行了全机器人PSD和体内十二指肠空肠造口术,该患者在十二指肠D3部分有2.2 cm的无根息肉和发育不良。虽然PSD并不表示恶性肿瘤,但在某些情况下,术中冷冻切片阴性是至关重要的。一个关键的学习点是将机器人可视化与上内窥镜相结合,以准确地确定壶腹和病变之间的距离,确保肿瘤边缘。本文概述了在技术上具有挑战性的情况下的逐步手术方法,旨在保护患者的安全,并使用完全机器人技术提供肿瘤良性切除。
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引用次数: 0
Gastric diverticulum: incidental finding in preoperative study. 胃憩室:术前研究中偶然发现。
Pub Date : 2025-12-03 DOI: 10.1016/j.cireng.2025.800253
Mónica Pujante Menchón, Asunción Candela Gomis, Laura Rius Acebes, Antonio F Compañ Rosique
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引用次数: 0
Can we decrease the risk of complex liver surgery with the new GLP1 and GIP analogues? 我们可以用新的GLP1和GIP类似物降低复杂肝脏手术的风险吗?
Pub Date : 2025-12-02 DOI: 10.1016/j.cireng.2025.800264
Iago Justo, María Calatayud, Javier Salamanca, María Camara, Alvaro García-Sesma, Carmelo Loinaz
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引用次数: 0
Predictive values of axillary involvement in breast cancer 腋窝受累对乳腺癌的预测价值。
Pub Date : 2025-12-01 DOI: 10.1016/j.cireng.2025.800231
Laura Comín Novella , Mónica Oset García , Marta González Pérez , El Mostafa el Yaqine er Raoudi , Pedro Pablo Stredel Russian , Francisco Luis Carrillo Trabalón , Sandra Lario Pérez , José Francisco Noguera Aguilar

Introduction

In breast cancer, recommendations for axillary surgery are currently shifting toward omitting SLNB. Studies have shown that not performing axillary staging has no impact on regional control or survival and translates into improved quality of life. We sought to determine whether certain clinical factors such as tumor size or type, immunohistochemical characteristics, tumor grade or Ki 67 value are predictive of metastatic disease in the lymph nodes.

Methods

A retrospective observational study was conducted of patients who underwent breast cancer surgery during the years 2019–2024. Inclusion criteria were: tumor size equal to or less than 2 cm as measured by ultrasound, and axilla that was clinically and ultrasound-negative.

Results

One hundred and fifty-six breasts were operated on, with a mean age of 64.5 years. Regarding immunohistochemistry, tumor grade, and age, no differences were observed. However, patients with tumors >2 cm and lobular tumors did have greater lymph node involvement (P < .05).

Conclusions

There are no variables that predict lymph node involvement before surgery. Today, we are not prepared to lose the information provided by SLNB, and part of the postoperative treatment is determined by its results.
简介:在乳腺癌中,腋窝手术的建议目前正在转向省略SLNB。研究表明,不进行腋窝分期对局部控制或生存没有影响,并转化为生活质量的提高。我们试图确定某些临床因素,如肿瘤大小或类型、免疫组织化学特征、肿瘤分级或Ki 67值是否可预测淋巴结转移性疾病。方法:对2019-2024年间接受乳腺癌手术的患者进行回顾性观察研究。纳入标准:超声测量肿瘤大小等于或小于2cm,临床及超声阴性腋窝。结果:共手术156例,平均年龄64.5岁。在免疫组化、肿瘤分级和年龄方面,没有观察到差异。然而,肿瘤bbb2cm和小叶肿瘤患者确实有更大的淋巴结累及(P)结论:术前没有预测淋巴结累及的变量。今天,我们不准备失去SLNB提供的信息,部分术后治疗取决于其结果。
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引用次数: 0
Inguinoscrotal hernia with bladder herniation and ureterohydronephrosis 腹股沟阴囊疝合并膀胱疝和输尿管肾积水。
Pub Date : 2025-12-01 DOI: 10.1016/j.cireng.2025.800243
Gema Cabanillas Vera , Alejandro Rodriguez Caballero , Alberto Hernández Matías , Sara Gortázar de las Casas
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引用次数: 0
Hepatic gas gangrene 肝气性坏疽。
Pub Date : 2025-12-01 DOI: 10.1016/j.cireng.2025.800241
María del Mar Gómez Cisneros , Cristina Méndez García , Jesús Cañete Gómez , Pablo Parra-Membrives
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引用次数: 0
期刊
Cirugia espanola
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