Experimental gerontology最新文献_第8页

Exergaming interventions for older adults: The effect of game characteristics on gameplay 针对老年人的外部游戏干预：游戏特征对游戏性的影响。

IF 3.9

Experimental gerontology

Pub Date : 2024-10-20 DOI: 10.1016/j.exger.2024.112610

Helen Müller , Nina Skjæret-Maroni , Ellen Marie Bardal , Beatrix Vereijken , Jochen Baumeister

Purpose

Exergames can be used to train physical and cognitive abilities and have been shown to be effective in reducing the risk of falls in older adults. However, there is limited evidence about how people play exergames and how gameplay is affected by game settings and, thus, the potential training effects. The aim of this study was to investigate the impact of repeated exergaming sessions over 4 weeks and two game settings (difficulty level and game speed) on gameplay (performance, physical activity and perceived exertion) in older adults over a four-week exergaming intervention.

Methods

28 independently living older adults (mean age 74.47 years; 14 females) played two different exergames (Puzzle and Fox) at two difficulty levels 3× per week for 4 weeks. Physical activity measures from an accelerometer at the lower back, performance as game scores from the exergaming system, and self-reported measures of physical and cognitive exertion were collected at sessions 1,2,3,6,9 and 12.

Results

For the Puzzle game, performance and physical activity increased significantly across the 12 training sessions. For the Fox game, an increased game speed was associated with increased performance, physical activity, and exertion across the exergaming sessions. Across all exergaming sessions, increasing difficulty by adding cognitive elements decreased the performance and amount of physical activity.

Conclusion

Game characteristics significantly influence how the exergames are played during a 4-week exergaming intervention. Hence, individual tailoring of the difficulty level and game speed is important. This study highlights the importance of understanding the interplay between game characteristics and gameplay during an exergaming intervention, thereby adding critical information for interpreting intervention effects – or the lack thereof.

目的：体外游戏可用于训练体能和认知能力，并被证明可有效降低老年人跌倒的风险。然而，关于人们如何玩外部游戏、游戏设置对游戏性的影响以及潜在的训练效果等方面的证据却很有限。本研究的目的是调查在为期四周的外显子游戏干预中，4周内重复外显子游戏课程和两种游戏设置（难度级别和游戏速度）对老年人游戏（表现、体力活动和感知消耗）的影响。方法：28名独立生活的老年人（平均年龄74.47岁；14名女性）在4周内每周3次玩两种不同难度级别的外显子游戏（拼图和狐狸）。在第 1、2、3、6、9 和 12 次游戏中，收集了腰部加速度计的体力活动测量值、外显子游戏系统的游戏成绩以及自我报告的体力和认知消耗测量值：益智游戏的成绩和体力活动在 12 次训练中显著增加。在狐狸游戏中，游戏速度的提高与各次运动训练中成绩、体力活动和消耗的增加有关。在所有外显子游戏训练中，通过增加认知元素来提高难度会降低成绩和体力活动量：结论：在为期四周的外显子游戏干预中，游戏特征对外显子游戏的玩法有很大影响。因此，根据个人情况调整游戏难度和速度非常重要。这项研究强调了了解外显子游戏干预过程中游戏特征和游戏方式之间相互作用的重要性，从而为解释干预效果或缺乏干预效果提供了重要信息。

{"title":"Exergaming interventions for older adults: The effect of game characteristics on gameplay","authors":"Helen Müller , Nina Skjæret-Maroni , Ellen Marie Bardal , Beatrix Vereijken , Jochen Baumeister","doi":"10.1016/j.exger.2024.112610","DOIUrl":"10.1016/j.exger.2024.112610","url":null,"abstract":"<div><h3>Purpose</h3><div>Exergames can be used to train physical and cognitive abilities and have been shown to be effective in reducing the risk of falls in older adults. However, there is limited evidence about how people play exergames and how gameplay is affected by game settings and, thus, the potential training effects. The aim of this study was to investigate the impact of repeated exergaming sessions over 4 weeks and two game settings (difficulty level and game speed) on gameplay (performance, physical activity and perceived exertion) in older adults over a four-week exergaming intervention.</div></div><div><h3>Methods</h3><div>28 independently living older adults (mean age 74.47 years; 14 females) played two different exergames (Puzzle and Fox) at two difficulty levels 3× per week for 4 weeks. Physical activity measures from an accelerometer at the lower back, performance as game scores from the exergaming system, and self-reported measures of physical and cognitive exertion were collected at sessions 1,2,3,6,9 and 12.</div></div><div><h3>Results</h3><div>For the Puzzle game, performance and physical activity increased significantly across the 12 training sessions. For the Fox game, an increased game speed was associated with increased performance, physical activity, and exertion across the exergaming sessions. Across all exergaming sessions, increasing difficulty by adding cognitive elements decreased the performance and amount of physical activity.</div></div><div><h3>Conclusion</h3><div>Game characteristics significantly influence how the exergames are played during a 4-week exergaming intervention. Hence, individual tailoring of the difficulty level and game speed is important. This study highlights the importance of understanding the interplay between game characteristics and gameplay during an exergaming intervention, thereby adding critical information for interpreting intervention effects – or the lack thereof.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112610"},"PeriodicalIF":3.9,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of moderate-intensity aquatic treadmill exercise on cognitive function and cerebral blood flow for healthy older adults 中等强度水上跑步机运动对健康老年人认知功能和脑血流量的影响。

IF 3.9

Experimental gerontology

Pub Date : 2024-10-19 DOI: 10.1016/j.exger.2024.112605

Billy, C.L. So , Hiko, C.Y. Cheung , Y.P. Zheng , Manny, M.Y. Kwok , Eugenie, Y.K. Man , Fabiola, Tang Mok , Gerald, C.N. Ng , Nicco, N.L. Sze , Stella, W.S. Tang , Shamay, S.M. Ng

To compare the effect of moderate-intensity aquatic treadmill exercise (ATM) on cerebral blood flow (CBF) and cognitive function in healthy older adults to that of moderate-intensity land-based treadmill exercise (LTM). This randomized controlled trial study was conducted between May 2023 and Oct 2023. Twenty-eight participants aged 60–80 were randomly assigned to either ATM group (N = 14) or LTM group (N = 14). Cognitive function and cerebral blood flow were assessed before and after the exercise. The outcome measures used in this study were the Digit Symbol Substitution Test (DSST) and the Digit Span Test (DST) to assess cognitive performance, and the mean middle cerebral artery blood velocity (MCAvmean) to evaluate CBF. A mixed effects model was used to analyze the within-group and between-group differences in cognitive function and CBF outcomes pre-to-post treadmill by SPSS. The DSST demonstrated a statistically significant improvement within both the ATM [β ± SE: −13.643 ± 2.407, 95 % CI: −18.749, −8.537] and LTM [β ± SE: −19.25 ± 3.66, 95 % CI: −26.424, −12.076] groups, indicating clinical significance in both groups. Both ATM and LTM groups exhibited post-exercise improvements within their respective groups for forward Digit Span Test (FDST) [ATM β ± SE: −0.143 ± 0.362, 95 % CI: −0.92, 0.634; LTM β ± SE: −0.286 ± 0.37, 95 % CI: −1.078, 0.506] and backward Digit Span Test (BDST) (ATM β ± SE: −1.741 ± 5.377, 95 % CI: −13.27, 9.792; LTM β ± SE: −6.729 ± 5.370, 95 % CI: −4.788, 18.24). In terms of MCAv_mean, there is a higher improvement of CBF in ATM group [β ± SE: −138.669 ± 67.9217, 95 % CI: −288.164, 10.826] than LTM group [β ± SE: −9.305 ± 70.076, 95 % CI: −153.617, 135.007]. Hence, a single bout of moderate-intensity ATM and LTM can enhance cognitive function and CBF in healthy older adults, suggesting their potential as preventive strategies against age-related declines.

目的：比较中等强度的水中跑步机运动（ATM）与中等强度的陆上跑步机运动（LTM）对健康老年人脑血流量（CBF）和认知功能的影响。这项随机对照试验研究于 2023 年 5 月至 2023 年 10 月间进行。28 名 60-80 岁的参与者被随机分配到 ATM 组（14 人）或 LTM 组（14 人）。运动前后对认知功能和脑血流量进行了评估。本研究采用数字符号替换测试（DSST）和数字跨度测试（DST）来评估认知能力，并采用大脑中动脉平均血流速度（MCAvmean）来评估脑血流。SPSS采用混合效应模型分析了跑步机前后认知功能和CBF结果的组内和组间差异。DSST 在 ATM 组[β±SE：-13.643 ± 2.407，95 % CI：-18.749, -8.537]和 LTM 组[β±SE：-19.25 ± 3.66，95 % CI：-26.424, -12.076]均有统计学意义上的显著改善，表明两组均有临床意义。在前向数字跨度测试（FDST）方面，ATM 组和 LTM 组在各自组别内均表现出运动后的改善[ATM β ± SE：-0.143 ± 0.362，95 % CI：-0.92，0.634；LTM β ± SE：-0.286±0.37，95 % CI：-1.078，0.506]和后向数字跨度测试（BDST）（ATM β±SE：-1.741±5.377，95 % CI：-13.27，9.792；LTM β±SE：-6.729±5.370，95 % CI：-4.788，18.24）。就 MCAvmean 而言，ATM 组的 CBF 改善程度 [β±SE：-138.669 ± 67.9217，95 % CI：-288.164，10.826] 高于 LTM 组 [β±SE：-9.305 ± 70.076，95 % CI：-153.617，135.007]。因此，单次中等强度的 ATM 和 LTM 可增强健康老年人的认知功能和 CBF，这表明它们有可能成为预防与年龄有关的衰退的策略。

{"title":"Effect of moderate-intensity aquatic treadmill exercise on cognitive function and cerebral blood flow for healthy older adults","authors":"Billy, C.L. So , Hiko, C.Y. Cheung , Y.P. Zheng , Manny, M.Y. Kwok , Eugenie, Y.K. Man , Fabiola, Tang Mok , Gerald, C.N. Ng , Nicco, N.L. Sze , Stella, W.S. Tang , Shamay, S.M. Ng","doi":"10.1016/j.exger.2024.112605","DOIUrl":"10.1016/j.exger.2024.112605","url":null,"abstract":"<div><div>To compare the effect of moderate-intensity aquatic treadmill exercise (ATM) on cerebral blood flow (CBF) and cognitive function in healthy older adults to that of moderate-intensity land-based treadmill exercise (LTM). This randomized controlled trial study was conducted between May 2023 and Oct 2023. Twenty-eight participants aged 60–80 were randomly assigned to either ATM group (N = 14) or LTM group (N = 14). Cognitive function and cerebral blood flow were assessed before and after the exercise. The outcome measures used in this study were the Digit Symbol Substitution Test (DSST) and the Digit Span Test (DST) to assess cognitive performance, and the mean middle cerebral artery blood velocity (MCAvmean) to evaluate CBF. A mixed effects model was used to analyze the within-group and between-group differences in cognitive function and CBF outcomes pre-to-post treadmill by SPSS. The DSST demonstrated a statistically significant improvement within both the ATM [β ± SE: −13.643 ± 2.407, 95 % CI: −18.749, −8.537] and LTM [β ± SE: −19.25 ± 3.66, 95 % CI: −26.424, −12.076] groups, indicating clinical significance in both groups. Both ATM and LTM groups exhibited post-exercise improvements within their respective groups for forward Digit Span Test (FDST) [ATM β ± SE: −0.143 ± 0.362, 95 % CI: −0.92, 0.634; LTM β ± SE: −0.286 ± 0.37, 95 % CI: −1.078, 0.506] and backward Digit Span Test (BDST) (ATM β ± SE: −1.741 ± 5.377, 95 % CI: −13.27, 9.792; LTM β ± SE: −6.729 ± 5.370, 95 % CI: −4.788, 18.24). In terms of MCAv<sub>mean</sub>, there is a higher improvement of CBF in ATM group [β ± SE: −138.669 ± 67.9217, 95 % CI: −288.164, 10.826] than LTM group [β ± SE: −9.305 ± 70.076, 95 % CI: −153.617, 135.007]. Hence, a single bout of moderate-intensity ATM and LTM can enhance cognitive function and CBF in healthy older adults, suggesting their potential as preventive strategies against age-related declines.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112605"},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LRE-MMF: A novel multi-modal fusion algorithm for detecting neurodegeneration in Parkinson's disease among the geriatric population LRE-MMF：用于检测老年帕金森病神经变性的新型多模态融合算法。

IF 3.9

Experimental gerontology

Pub Date : 2024-10-16 DOI: 10.1016/j.exger.2024.112585

Indranath Chatterjee , Videsha Bansal

Parkinson's disease (PD) is a prevalent neurological disorder characterized by progressive dopaminergic neuron loss, leading to both motor and non-motor symptoms. Early and accurate diagnosis is challenging due to the subtle and variable nature of early symptoms. This study aims to address these diagnostic challenges by proposing a novel method, Localized Region Extraction and Multi-Modal Fusion (LRE-MMF), designed to enhance diagnostic accuracy through the integration of structural MRI (sMRI) and resting-state functional MRI (rs-fMRI) data. The LRE-MMF method utilizes the complementary strengths of sMRI and rs-fMRI: sMRI provides detailed anatomical information, while rs-fMRI captures functional connectivity patterns. We applied this approach to a dataset consisting of 20 PD patients and 20 healthy controls (HC), all scanned with a 3 T MRI. The primary objective was to determine whether the integration of sMRI and rs-fMRI through the LRE-MMF method improves the classification accuracy between PD and HC subjects. LRE-MMF involves the division of imaging data into localized regions, followed by feature extraction and dimensionality reduction using Principal Component Analysis (PCA). The resulting features were fused and processed through a neural network to learn high-level representations. The model achieved an accuracy of 75 %, with a precision of 0.8125, recall of 0.65, and an AUC of 0.8875. The validation accuracy curves indicated good generalization, with significant brain regions identified, including the caudate, putamen, thalamus, supplementary motor area, and precuneus, as per the AAL atlas. These results demonstrate the potential of the LRE-MMF method for improving early diagnosis and understanding of PD by effectively utilizing both sMRI and rs-fMRI data. This approach could contribute to the development of more accurate diagnostic tools.

帕金森病（Parkinson's disease，PD）是一种常见的神经系统疾病，以进行性多巴胺能神经元缺失为特征，可导致运动和非运动症状。由于早期症状细微且多变，早期准确诊断具有挑战性。本研究旨在通过提出一种新方法--局部区域提取和多模态融合（LRE-MMF）--来解决这些诊断难题，该方法旨在通过整合结构磁共振成像（sMRI）和静息态功能磁共振成像（rs-fMRI）数据来提高诊断准确性。LRE-MMF 方法利用了 sMRI 和 rs-fMRI 的互补优势：sMRI 提供详细的解剖信息，而 rs-fMRI 则捕捉功能连接模式。我们将这种方法应用于一个数据集，该数据集由 20 名帕金森病患者和 20 名健康对照者（HC）组成，所有患者均使用 3 T MRI 扫描。主要目的是确定通过 LRE-MMF 方法整合 sMRI 和 rs-fMRI 是否能提高 PD 和 HC 受试者之间的分类准确性。LRE-MMF涉及将成像数据划分为局部区域，然后使用主成分分析（PCA）进行特征提取和降维。由此产生的特征通过神经网络进行融合和处理，以学习高级表征。该模型的准确率达到 75%，精确度为 0.8125，召回率为 0.65，AUC 为 0.8875。验证精确度曲线表明该模型具有良好的泛化能力，并根据 AAL 图谱识别出了重要的脑区，包括尾状核、丘脑、丘脑、辅助运动区和楔前肌。这些结果表明，LRE-MMF方法可有效利用sMRI和rs-fMRI数据，提高对帕金森病的早期诊断和理解。这种方法有助于开发更准确的诊断工具。

{"title":"LRE-MMF: A novel multi-modal fusion algorithm for detecting neurodegeneration in Parkinson's disease among the geriatric population","authors":"Indranath Chatterjee , Videsha Bansal","doi":"10.1016/j.exger.2024.112585","DOIUrl":"10.1016/j.exger.2024.112585","url":null,"abstract":"<div><div>Parkinson's disease (PD) is a prevalent neurological disorder characterized by progressive dopaminergic neuron loss, leading to both motor and non-motor symptoms. Early and accurate diagnosis is challenging due to the subtle and variable nature of early symptoms. This study aims to address these diagnostic challenges by proposing a novel method, Localized Region Extraction and Multi-Modal Fusion (LRE-MMF), designed to enhance diagnostic accuracy through the integration of structural MRI (sMRI) and resting-state functional MRI (rs-fMRI) data. The LRE-MMF method utilizes the complementary strengths of sMRI and rs-fMRI: sMRI provides detailed anatomical information, while rs-fMRI captures functional connectivity patterns. We applied this approach to a dataset consisting of 20 PD patients and 20 healthy controls (HC), all scanned with a 3 T MRI. The primary objective was to determine whether the integration of sMRI and rs-fMRI through the LRE-MMF method improves the classification accuracy between PD and HC subjects. LRE-MMF involves the division of imaging data into localized regions, followed by feature extraction and dimensionality reduction using Principal Component Analysis (PCA). The resulting features were fused and processed through a neural network to learn high-level representations. The model achieved an accuracy of 75 %, with a precision of 0.8125, recall of 0.65, and an AUC of 0.8875. The validation accuracy curves indicated good generalization, with significant brain regions identified, including the caudate, putamen, thalamus, supplementary motor area, and precuneus, as per the AAL atlas. These results demonstrate the potential of the LRE-MMF method for improving early diagnosis and understanding of PD by effectively utilizing both sMRI and rs-fMRI data. This approach could contribute to the development of more accurate diagnostic tools.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112585"},"PeriodicalIF":3.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake 卵泡耗竭后的空间学习和记忆障碍与海马葡萄糖摄取减少有关。

IF 3.9

Experimental gerontology

Pub Date : 2024-10-15 DOI: 10.1016/j.exger.2024.112607

Nur Zuliani Ramli , Mohamad Fairuz Yahaya , Nur Azlina Mohd Fahami , Hamizah Shahirah Hamezah , Zulzikry Hafiz Abu Bakar , Aslina Pahrudin Arrozi , Daijiro Yanagisawa , Ikuo Tooyama , Meharvan Singh , Hanafi Ahmad Damanhuri

The menopausal transition is a complex neuroendocrine aging process affecting brain structure and metabolic function. Such changes are consistent with neurological sequelae noted following the menopausal transition, including cognitive deficits. Although studies in rodent models of the menopause revealed changes in learning and memory, little is known about the structural and metabolic changes in the brain regions serving the cognitive function in these models. The administration 4-vinylcyclohexene diepoxide (VCD) in laboratory animals results in follicular depletion, and thus, is a powerful translational tool that models the human menopause. In the studies presented here, we evaluated behavior, brain structure, and metabolism in young female rats administered with either VCD or vehicle for 15 days across the early, mid, and post-follicular depletion states at 1-, 2-, and 3-months post-final injection, respectively. Additionally, we evaluated the serum hormonal profile and ovarian follicles based on the estrous cycle pattern. Positron emission tomography (PET) was utilized to determine regional brain glucose metabolism in the hippocampus, medial prefrontal cortex, and striatum. Subsequently, the rats were euthanized for ex-vivo magnetic resonance imaging (MRI) to assess regional brain volumes. VCD-induced rats at the post-follicular depleted time points had diminished spatial learning and memory as well as reduced hippocampal glucose uptake. Additionally, VCD-induced rats at post-follicular depletion time points had marked reductions in estradiol, progesterone, and anti-mullerian hormone with an increase in follicle-stimulating hormone. These rats also exhibited fewer ovarian follicles, indicating that substantial ovarian function loss during post-follicular time points impairs the female rats' spatial learning/memory abilities and triggers the metabolic changes in the hippocampus.

绝经过渡期是一个复杂的神经内分泌老化过程，会影响大脑结构和代谢功能。这种变化与更年期过渡后出现的神经系统后遗症（包括认知障碍）是一致的。尽管对更年期啮齿动物模型的研究显示了学习和记忆方面的变化，但人们对这些模型中具有认知功能的大脑区域的结构和代谢变化知之甚少。在实验动物体内施用 4-乙烯基环己烯二环氧化物（VCD）会导致卵泡耗竭，因此是模拟人类更年期的一种强大的转化工具。在本文介绍的研究中，我们对年轻雌性大鼠的行为、大脑结构和新陈代谢进行了评估，这些大鼠分别在卵泡耗竭的早期、中期和后期，在最后注射后的 1 个月、2 个月和 3 个月内服用了 15 天的 VCD 或药物。此外，我们还根据发情周期模式评估了血清激素谱和卵巢滤泡。正电子发射断层扫描（PET）用于测定海马、内侧前额叶皮层和纹状体的区域脑葡萄糖代谢。随后，大鼠被安乐死，进行体外磁共振成像（MRI）以评估区域脑容量。VCD诱导的大鼠在卵泡耗竭后时间点的空间学习和记忆能力减弱，海马葡萄糖摄取量减少。此外，VCD 诱导的大鼠在卵泡耗竭后时间点的雌二醇、孕酮和抗苗勒氏管激素明显减少，而促卵泡激素增加。这些大鼠还表现出较少的卵巢滤泡，表明在卵泡后时间点卵巢功能的大量丧失损害了雌性大鼠的空间学习/记忆能力，并引发了海马的新陈代谢变化。

{"title":"Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake","authors":"Nur Zuliani Ramli , Mohamad Fairuz Yahaya , Nur Azlina Mohd Fahami , Hamizah Shahirah Hamezah , Zulzikry Hafiz Abu Bakar , Aslina Pahrudin Arrozi , Daijiro Yanagisawa , Ikuo Tooyama , Meharvan Singh , Hanafi Ahmad Damanhuri","doi":"10.1016/j.exger.2024.112607","DOIUrl":"10.1016/j.exger.2024.112607","url":null,"abstract":"<div><div>The menopausal transition is a complex neuroendocrine aging process affecting brain structure and metabolic function. Such changes are consistent with neurological sequelae noted following the menopausal transition, including cognitive deficits. Although studies in rodent models of the menopause revealed changes in learning and memory, little is known about the structural and metabolic changes in the brain regions serving the cognitive function in these models. The administration 4-vinylcyclohexene diepoxide (VCD) in laboratory animals results in follicular depletion, and thus, is a powerful translational tool that models the human menopause. In the studies presented here, we evaluated behavior, brain structure, and metabolism in young female rats administered with either VCD or vehicle for 15 days across the early, mid, and post-follicular depletion states at 1-, 2-, and 3-months post-final injection, respectively. Additionally, we evaluated the serum hormonal profile and ovarian follicles based on the estrous cycle pattern. Positron emission tomography (PET) was utilized to determine regional brain glucose metabolism in the hippocampus, medial prefrontal cortex, and striatum. Subsequently, the rats were euthanized for ex-vivo magnetic resonance imaging (MRI) to assess regional brain volumes. VCD-induced rats at the post-follicular depleted time points had diminished spatial learning and memory as well as reduced hippocampal glucose uptake. Additionally, VCD-induced rats at post-follicular depletion time points had marked reductions in estradiol, progesterone, and anti-mullerian hormone with an increase in follicle-stimulating hormone. These rats also exhibited fewer ovarian follicles, indicating that substantial ovarian function loss during post-follicular time points impairs the female rats' spatial learning/memory abilities and triggers the metabolic changes in the hippocampus.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112607"},"PeriodicalIF":3.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobiological and anti-aging benefits of yoga: A comprehensive review of recent advances in non-pharmacological therapy. 瑜伽对神经生物学和抗衰老的益处：全面回顾非药物疗法的最新进展。

IF 3.9

Experimental gerontology

Pub Date : 2024-10-15 Epub Date: 2024-09-02 DOI: 10.1016/j.exger.2024.112550

Qiaoyan Chen

Aging is an unavoidable process marked by numerous physiological and psychological changes that profoundly impact overall health and quality of life. As the global population ages, there is a growing interest in non-pharmacological therapies that can mitigate the adverse effects of aging and promote longevity. This narrative review explores the broad spectrum of non-pharmacological mechanisms offering anti-aging benefits, with a special emphasis on holistic practices such as yoga, meditation, and lifestyle interventions. These therapies influence critical biological processes, including reducing oxidative stress, modulating chronic inflammation, enhancing immune function, and preserving telomere length-key markers of cellular aging. Additionally, these practices contribute to improved cardiovascular health, musculoskeletal strength, and mental well-being, fostering a comprehensive approach to healthy aging. Yoga, for instance, combines physical postures, breath control, and meditation to enhance physical flexibility, mental clarity, and emotional balance. Meditation practices are shown to reduce stress and improve cognitive function, further supporting healthy aging. Lifestyle modifications, such as diet and regular physical activity, complement these therapies by promoting overall vitality and reducing the risk of age-related diseases. This review underscores the potential of integrating these non-pharmacological strategies into daily routines to enhance resilience against aging, improve quality of life, and extend healthspan. Furthermore, it highlights the need for continued research to fully elucidate the mechanisms by which these therapies exert their anti-aging effects and to develop evidence-based guidelines for their implementation.

衰老是一个不可避免的过程，其特点是生理和心理上的诸多变化，对整体健康和生活质量产生深远影响。随着全球人口老龄化的加剧，人们对能够减轻衰老的不利影响并促进长寿的非药物疗法越来越感兴趣。这篇叙述性综述探讨了具有抗衰老功效的各种非药物疗法机制，并特别强调了瑜伽、冥想和生活方式干预等整体疗法。这些疗法会影响关键的生物过程，包括减少氧化应激、调节慢性炎症、增强免疫功能和保持端粒长度--细胞衰老的关键标志物。此外，这些疗法还有助于改善心血管健康、肌肉骨骼力量和心理健康，从而促进健康老龄化的综合方法。例如，瑜伽将身体姿势、呼吸控制和冥想结合在一起，可增强身体灵活性、头脑清晰度和情绪平衡。冥想练习可减轻压力，改善认知功能，进一步促进健康老龄化。调整生活方式，如饮食和有规律的体育锻炼，通过促进整体活力和降低老年相关疾病的风险来补充这些疗法。本综述强调了将这些非药物疗法融入日常生活的潜力，以增强抗衰老能力、提高生活质量并延长健康寿命。此外，它还强调了继续研究的必要性，以充分阐明这些疗法发挥抗衰老作用的机制，并为其实施制定循证指南。

{"title":"Neurobiological and anti-aging benefits of yoga: A comprehensive review of recent advances in non-pharmacological therapy.","authors":"Qiaoyan Chen","doi":"10.1016/j.exger.2024.112550","DOIUrl":"10.1016/j.exger.2024.112550","url":null,"abstract":"<p><p>Aging is an unavoidable process marked by numerous physiological and psychological changes that profoundly impact overall health and quality of life. As the global population ages, there is a growing interest in non-pharmacological therapies that can mitigate the adverse effects of aging and promote longevity. This narrative review explores the broad spectrum of non-pharmacological mechanisms offering anti-aging benefits, with a special emphasis on holistic practices such as yoga, meditation, and lifestyle interventions. These therapies influence critical biological processes, including reducing oxidative stress, modulating chronic inflammation, enhancing immune function, and preserving telomere length-key markers of cellular aging. Additionally, these practices contribute to improved cardiovascular health, musculoskeletal strength, and mental well-being, fostering a comprehensive approach to healthy aging. Yoga, for instance, combines physical postures, breath control, and meditation to enhance physical flexibility, mental clarity, and emotional balance. Meditation practices are shown to reduce stress and improve cognitive function, further supporting healthy aging. Lifestyle modifications, such as diet and regular physical activity, complement these therapies by promoting overall vitality and reducing the risk of age-related diseases. This review underscores the potential of integrating these non-pharmacological strategies into daily routines to enhance resilience against aging, improve quality of life, and extend healthspan. Furthermore, it highlights the need for continued research to fully elucidate the mechanisms by which these therapies exert their anti-aging effects and to develop evidence-based guidelines for their implementation.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112550"},"PeriodicalIF":3.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the impact of internet-enabled nursing practices, guided by specialist nurses on patients with hypertension and their caregivers 研究由专科护士指导的互联网护理实践对高血压患者及其护理人员的影响。

IF 3.9

Experimental gerontology

Pub Date : 2024-10-15 DOI: 10.1016/j.exger.2024.112606

Xiao-Juan He , Xin-Yu Yi , Na Wei

Purpose

To aim of this study is to assess the impact of an internet-enabled nursing model, led by specialized nurses within a framework of multidisciplinary collaboration, on both, patients diagnosed with hypertension, and their respective caregivers.

Methods

A total of 158 patients with hypertension, along with their corresponding caregivers, were meticulously selected and paired. By using a random number table method, participants were allocated into either a control group or an observation group. The control group received conventional health education, blood pressure monitoring, and routine telephone follow-ups administered by designated nurses. Conversely, patients in the observation group underwent treatment within an internet-enabled nursing model, led by specialist nurses within a multidisciplinary collaborative framework. Parameters including systolic and diastolic blood pressure readings of the patients, as well as their scores in compliance with the hypertension treatment, quality of life, and caregiving proficiency of family members, which were meticulously documented prior to intervention (T₀), as well as at 3- and 6-month intervals post-intervention (T₁ and T₂).

Results

Statistically significant differences were observed in both systolic and diastolic blood pressure levels among patients, as well as in their scores reflecting compliance with hypertension treatment, quality of life, and caregiving proficiency of family members, when comparing pre- and post-intervention periods within each group, across groups, and within the interaction effect (p < 0.05). Also, there were statistically significant differences in the aforementioned parameters between the two groups at adjacent time points (p < 0.05). Specifically, patients within the observation group exhibited notable reductions in systolic and diastolic blood pressure levels at both T₁ and T₂, alongside heightened scores indicative of enhanced compliance with hypertension treatment, enhanced quality of life, and increased caregiving proficiency among family members, when compared to patients within the control group (p < 0.05).

Conclusion

The implementation of an internet-enabled nursing model, overseen by specialized nurses within a framework of multidisciplinary collaboration, demonstrates superior efficacy in preserving the stability of blood pressure among patients with hypertension. This model significantly enhances patient compliance with treatment regimens, enhances their overall quality of life, and fosters heightened caregiving proficiency among their respective caregivers.

目的：本研究旨在评估在多学科合作框架内由专科护士领导的互联网护理模式对高血压患者及其护理人员的影响：方法：精心挑选并配对了 158 名高血压患者及其护理人员。采用随机数字表法，将参与者分配到对照组或观察组。对照组接受常规健康教育、血压监测和由指定护士进行的例行电话随访。相反，观察组的患者则在多学科协作框架内接受由专科护士领导的互联网护理模式的治疗。干预前（T0）、干预后 3 个月和 6 个月（T1 和 T2），对患者的收缩压和舒张压读数、高血压治疗依从性评分、生活质量和家庭成员的护理能力等参数进行了详细记录：结果：与对照组患者相比，在干预前和干预后各组内、各组间和交互效应内（P1 和 T2），患者的收缩压和舒张压水平以及反映高血压治疗依从性、生活质量和家庭成员护理能力的评分均有统计学意义的差异（P 结论：实施互联网护理干预后，患者的收缩压和舒张压水平均有所改善：在多学科协作的框架内，由专业护士监督实施的互联网护理模式在保持高血压患者血压稳定方面显示出卓越的疗效。这种模式大大提高了患者对治疗方案的依从性，改善了他们的整体生活质量，并提高了各自护理人员的护理能力。

{"title":"Examining the impact of internet-enabled nursing practices, guided by specialist nurses on patients with hypertension and their caregivers","authors":"Xiao-Juan He , Xin-Yu Yi , Na Wei","doi":"10.1016/j.exger.2024.112606","DOIUrl":"10.1016/j.exger.2024.112606","url":null,"abstract":"<div><h3>Purpose</h3><div>To aim of this study is to assess the impact of an internet-enabled nursing model, led by specialized nurses within a framework of multidisciplinary collaboration, on both, patients diagnosed with hypertension, and their respective caregivers.</div></div><div><h3>Methods</h3><div>A total of 158 patients with hypertension, along with their corresponding caregivers, were meticulously selected and paired. By using a random number table method, participants were allocated into either a control group or an observation group. The control group received conventional health education, blood pressure monitoring, and routine telephone follow-ups administered by designated nurses. Conversely, patients in the observation group underwent treatment within an internet-enabled nursing model, led by specialist nurses within a multidisciplinary collaborative framework. Parameters including systolic and diastolic blood pressure readings of the patients, as well as their scores in compliance with the hypertension treatment, quality of life, and caregiving proficiency of family members, which were meticulously documented prior to intervention (T<sub>0</sub>), as well as at 3- and 6-month intervals post-intervention (T<sub>1</sub> and T<sub>2</sub>).</div></div><div><h3>Results</h3><div>Statistically significant differences were observed in both systolic and diastolic blood pressure levels among patients, as well as in their scores reflecting compliance with hypertension treatment, quality of life, and caregiving proficiency of family members, when comparing pre- and post-intervention periods within each group, across groups, and within the interaction effect (<em>p</em> < 0.05). Also, there were statistically significant differences in the aforementioned parameters between the two groups at adjacent time points (<em>p</em> < 0.05). Specifically, patients within the observation group exhibited notable reductions in systolic and diastolic blood pressure levels at both T<sub>1</sub> and T<sub>2</sub>, alongside heightened scores indicative of enhanced compliance with hypertension treatment, enhanced quality of life, and increased caregiving proficiency among family members, when compared to patients within the control group (<em>p</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>The implementation of an internet-enabled nursing model, overseen by specialized nurses within a framework of multidisciplinary collaboration, demonstrates superior efficacy in preserving the stability of blood pressure among patients with hypertension. This model significantly enhances patient compliance with treatment regimens, enhances their overall quality of life, and fosters heightened caregiving proficiency among their respective caregivers.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112606"},"PeriodicalIF":3.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of tamoxifen as an adjuvant therapy for breast cancer on apolipoproteins and lipoprotein(a) concentrations in women: A meta-analysis of randomized controlled trials 他莫昔芬作为乳腺癌辅助疗法对妇女体内脂蛋白和脂蛋白（a）浓度的影响：随机对照试验的荟萃分析。

IF 3.9

Experimental gerontology

Pub Date : 2024-10-11 DOI: 10.1016/j.exger.2024.112587

Bohua Zhang , Yafang Huang , Jingjing Zhang , Wenbo Fu , Kousalya Prabahar , Benjamin Hernández-Wolters , Hua Hu , Fei Hao

Background and aim

Tamoxifen has been used in the management of breast cancer. The available evidence on the effect of tamoxifen on lipoprotein(a) and apolipoproteins is controversial. Hence, this meta-analysis of randomized controlled trials (RCTs) was conducted to increase the quality of evidence on the effect of tamoxifen on lipoprotein(a) and apolipoproteins.

Methods

Eligible RCTs published up to September 2023 were carefully selected following a comprehensive search. Thereafter, a meta-analysis was conducted using a random-effects model and the results were presented as the weighted mean difference (WMD) with a 95 % confidence interval (CI).

Results

The results from the random-effects model indicated a rise in ApoA-I (WMD: 16.24 mg/dL, 95 % CI: 5.35, 27.12, P = 0.003), and a decrease in ApoB (WMD: −9.37 mg/dL, 95 % CI: −15.16, −3.59, P = 0.001) and lipoprotein(a) (WMD: −3.24 mg/dL, 95 % CI: −5.66, −0.83, P < 0.001) concentrations following tamoxifen administration in women. Furthermore, a more pronounced decrease in ApoB (WMD: −12.86 mg/dL, 95 % CI: −19.78, −5.93, P < 0.001) and elevation in ApoA-1 levels (WMD: 51.97 mg/dL, 95 % CI: 45.89, 58.05, P < 0.001) were identified in a single study on patients with breast cancer.

Conclusion

The current meta-analysis demonstrated an increase of ApoA-I and a decrease of ApoB and lipoprotein(a) levels after treatment with tamoxifen in women.

背景和目的：他莫昔芬一直被用于治疗乳腺癌。关于他莫昔芬对脂蛋白（a）和脂蛋白的影响，现有证据尚存在争议。因此，我们对随机对照试验（RCTs）进行了荟萃分析，以提高他莫昔芬对脂蛋白（a）和脂蛋白影响的证据质量：方法：经过全面检索，精心挑选了截至 2023 年 9 月发表的符合条件的随机对照试验。随后，采用随机效应模型进行了荟萃分析，结果以加权平均差（WMD）和95%置信区间（CI）表示：随机效应模型的结果显示载脂蛋白 A-I 上升（WMD：16.24 mg/dL，95 % CI：5.35, 27.12，P = 0.003），载脂蛋白 B 下降（WMD：-9.37 mg/dL，95 % CI：-15.16, -3.59，P = 0.001），脂蛋白（a）下降（WMD：-3.24 mg/dL，95 % CI：-5.66, -0.83，P 结论：目前的荟萃分析表明，妇女使用他莫昔芬治疗后，载脂蛋白 A-I 水平升高，载脂蛋白 B 和脂蛋白（a）水平降低。

{"title":"The effect of tamoxifen as an adjuvant therapy for breast cancer on apolipoproteins and lipoprotein(a) concentrations in women: A meta-analysis of randomized controlled trials","authors":"Bohua Zhang , Yafang Huang , Jingjing Zhang , Wenbo Fu , Kousalya Prabahar , Benjamin Hernández-Wolters , Hua Hu , Fei Hao","doi":"10.1016/j.exger.2024.112587","DOIUrl":"10.1016/j.exger.2024.112587","url":null,"abstract":"<div><h3>Background and aim</h3><div>Tamoxifen has been used in the management of breast cancer. The available evidence on the effect of tamoxifen on lipoprotein(a) and apolipoproteins is controversial. Hence, this meta-analysis of randomized controlled trials (RCTs) was conducted to increase the quality of evidence on the effect of tamoxifen on lipoprotein(a) and apolipoproteins.</div></div><div><h3>Methods</h3><div>Eligible RCTs published up to September 2023 were carefully selected following a comprehensive search. Thereafter, a meta-analysis was conducted using a random-effects model and the results were presented as the weighted mean difference (WMD) with a 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>The results from the random-effects model indicated a rise in ApoA-I (WMD: 16.24 mg/dL, 95 % CI: 5.35, 27.12, <em>P</em> = 0.003), and a decrease in ApoB (WMD: −9.37 mg/dL, 95 % CI: −15.16, −3.59, <em>P</em> = 0.001) and lipoprotein(a) (WMD: −3.24 mg/dL, 95 % CI: −5.66, −0.83, <em>P</em> < 0.001) concentrations following tamoxifen administration in women. Furthermore, a more pronounced decrease in ApoB (WMD: −12.86 mg/dL, 95 % CI: −19.78, −5.93, <em>P</em> < 0.001) and elevation in ApoA-1 levels (WMD: 51.97 mg/dL, 95 % CI: 45.89, 58.05, P < 0.001) were identified in a single study on patients with breast cancer.</div></div><div><h3>Conclusion</h3><div>The current meta-analysis demonstrated an increase of ApoA-I and a decrease of ApoB and lipoprotein(a) levels after treatment with tamoxifen in women.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112587"},"PeriodicalIF":3.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating the effective age for dietary restriction and the key metabolites involved 阐明饮食限制的有效年龄和相关的关键代谢物。

IF 3.9

Experimental gerontology

Pub Date : 2024-10-10 DOI: 10.1016/j.exger.2024.112601

Jazween Loo, Geetha Gunasekaran, Jen Kit Tan, Jo Aan Goon

Dietary restriction (DR) extends lifespan in various species, but its effect at different ages, especially when started later, is unclear. This study used Caenorhabditis elegans to explore the impact of DR at different ages. Worms were divided into control and DR groups, with daily survival monitored. To confirm the occurrence of DR, the expression of DR-sensitive genes namely acdh-1, pyk-1, pck-2 and cts-1 were determined using RT-qPCR. Liquid chromatography mass spectrometry (LC-MS) was employed to observe the changes in metabolites affected by DR. The results indicated that young worms subjected to mild DR displayed the longest lifespan, highlighting the effectiveness of initiating DR at a young age. Increased expression of acdh-1 and pck-2 suggests activation of beta-oxidation and gluconeogenesis, while decreased cts-1 expression indicates a reduced citric acid cycle, further supporting the observed effects of DR in these worms. Metabolomic results indicated that DR decreased the activity of mechanistic Target of Rapamycin (mTOR) and the synthesis of amino acids namely leucine, tyrosine and tryptophan to conserve energy for cell repair and survival. DR also decreased levels of N-acetyl-L-methionine and S-adenosyl-methionine (SAM) in methionine metabolism, thereby promoting autophagy, reducing inflammation, and facilitating the removal of damaged cells and proteins. In conclusion, initiating dietary restriction early in life extends the lifespan by modulating amino acid metabolism and enhancing the autophagy pathway, thereby maintaining cellular wellbeing.

饮食限制（DR）可延长不同物种的寿命，但其在不同年龄段的影响尚不清楚，尤其是开始较晚时。本研究利用秀丽隐杆线虫来探讨 DR 在不同年龄段的影响。蠕虫被分为对照组和DR组，每天监测其存活率。为了证实 DR 的发生，使用 RT-qPCR 检测了 DR 敏感基因（即 acdh-1、pyk-1、pck-2 和 cts-1）的表达。结果表明，受轻度DR影响的幼虫寿命最长，这说明在幼虫时期启动DR是有效的。acdh-1和pck-2的表达量增加表明β-氧化和葡萄糖生成被激活，而ts-1的表达量减少表明柠檬酸循环减少，这进一步证实了在这些蠕虫中观察到的DR效应。代谢组学结果表明，DR 降低了雷帕霉素机械靶标（mTOR）的活性以及氨基酸（即亮氨酸、酪氨酸和色氨酸）的合成，从而为细胞修复和存活保存能量。DR 还能降低蛋氨酸代谢中 N-乙酰-L-蛋氨酸和 S-腺苷蛋氨酸（SAM）的水平，从而促进自噬，减轻炎症，并有利于清除受损细胞和蛋白质。总之，在生命早期开始限制饮食可通过调节氨基酸代谢和增强自噬途径延长寿命，从而维持细胞的健康。

{"title":"Elucidating the effective age for dietary restriction and the key metabolites involved","authors":"Jazween Loo, Geetha Gunasekaran, Jen Kit Tan, Jo Aan Goon","doi":"10.1016/j.exger.2024.112601","DOIUrl":"10.1016/j.exger.2024.112601","url":null,"abstract":"<div><div>Dietary restriction (DR) extends lifespan in various species, but its effect at different ages, especially when started later, is unclear. This study used <em>Caenorhabditis elegans</em> to explore the impact of DR at different ages. Worms were divided into control and DR groups, with daily survival monitored. To confirm the occurrence of DR, the expression of DR-sensitive genes namely <em>acdh-1</em>, <em>pyk-1</em>, <em>pck-2</em> and <em>cts-1</em> were determined using RT-qPCR. Liquid chromatography mass spectrometry (LC-MS) was employed to observe the changes in metabolites affected by DR. The results indicated that young worms subjected to mild DR displayed the longest lifespan, highlighting the effectiveness of initiating DR at a young age. Increased expression of <em>acdh-1</em> and <em>pck-2</em> suggests activation of beta-oxidation and gluconeogenesis, while decreased <em>cts-1</em> expression indicates a reduced citric acid cycle, further supporting the observed effects of DR in these worms. Metabolomic results indicated that DR decreased the activity of mechanistic Target of Rapamycin (mTOR) and the synthesis of amino acids namely leucine, tyrosine and tryptophan to conserve energy for cell repair and survival. DR also decreased levels of <em>N</em>-acetyl-L-methionine and S-adenosyl-methionine (SAM) in methionine metabolism, thereby promoting autophagy, reducing inflammation, and facilitating the removal of damaged cells and proteins. In conclusion, initiating dietary restriction early in life extends the lifespan by modulating amino acid metabolism and enhancing the autophagy pathway, thereby maintaining cellular wellbeing.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112601"},"PeriodicalIF":3.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The development of intrinsic capacity measures for longitudinal research: The Longitudinal Aging Study Amsterdam 开发用于纵向研究的内在能力测量方法：阿姆斯特丹老龄化纵向研究。

IF 3.9

Experimental gerontology

Pub Date : 2024-10-09 DOI: 10.1016/j.exger.2024.112599

Yuwei Qi , Laura A. Schaap , Benjamin D. Schalet , Emiel O. Hoogendijk , Dorly J.H. Deeg , Marjolein Visser , Kaisa Koivunen , Martijn Huisman , Natasja M. van Schoor

Background

The World Health Organization has introduced the construct of intrinsic capacity (IC) as an important component of healthy ageing and overall well-being in older adults The present study aimed to develop domain-specific and composite IC scores and to validate these scores by examining their longitudinal relation with functioning.

Methods

We used prospective data on participants aged 57 to over 90 years, with a 10-year follow-up, from the Longitudinal Aging Study Amsterdam, an ongoing cohort study of older Dutch men and women Using a formative, stepwise approach, we identified indicators across the different domains of IC, i.e. vitality, sensory, cognition, psychology, and locomotion, using a combination of unidimensional factor analyses and Partial Least Squares Structural Equation Modelling (PLS-SEM). Next, domain-specific and composite IC scores were generated, and the construct validity (score across age groups) and criterion validity (relationship with change in functional limitations) were assessed.

Results

The multiple unidimensional factor analyses and PLS-SEM identified a total of 18 indicators, covering the five domains of IC. The mean composite IC score was 70.9 (SD = 0.9) in men and 69.7 (0.8) in women. The domain-specific and composite IC scores all showed good construct validity, with known-group validation results indicating age-related declines. A higher composite IC score was associated with less functional limitations over time (B = 0.20, 95%CI [0.19, 0.22]).

Conclusion

The developed domain-specific IC scores and the composite IC score effectively discriminated age-related declines in IC. Additionally, the composite IC score was longitudinally associated with functional limitations. By creating this comprehensive and reliable tool for tracking IC, we aim to provide valuable insights into the dynamics of ageing and support more effective strategies for promoting health and well-being throughout later life. These scores establish a foundation for future research to track longitudinal changes across various IC domains and relate these changes to key age-related outcomes.

背景：本研究旨在开发特定领域和综合 IC 评分，并通过研究其与功能的纵向关系来验证这些评分：我们使用了 "阿姆斯特丹纵向老龄化研究"（Longitudinal Ageing Study Amsterdam）的前瞻性数据，该研究是一项对荷兰老年男性和女性进行的队列研究，参与者年龄从 57 岁到 90 岁以上，随访时间为 10 年。然后，生成了特定领域和综合 IC 分数，并评估了构建效度（不同年龄组的分数）和标准效度（与功能限制变化的关系）：多重单维因子分析和 PLS-SEM 共确定了 18 个指标，涵盖了 IC 的五个领域。男性的 IC 平均综合得分为 70.9（SD = 0.9），女性为 69.7（0.8）。特定领域的 IC 分值和 IC 综合分值均显示出良好的结构效度，已知组验证结果表明，IC 分值的下降与年龄有关。随着时间的推移，较高的综合 IC 分数与较少的功能限制相关（B = 0.20，95%CI [0.19，0.22]）：结论：已开发的特定领域 IC 评分和 IC 综合评分能有效区分与年龄相关的 IC 下降情况。此外，综合 IC 评分与功能限制存在纵向关联。通过创建这一全面、可靠的 IC 跟踪工具，我们旨在为老龄化动态提供有价值的见解，并为促进晚年健康和幸福的更有效策略提供支持。这些分值为今后的研究奠定了基础，以便追踪不同 IC 领域的纵向变化，并将这些变化与关键的年龄相关结果联系起来。

{"title":"The development of intrinsic capacity measures for longitudinal research: The Longitudinal Aging Study Amsterdam","authors":"Yuwei Qi , Laura A. Schaap , Benjamin D. Schalet , Emiel O. Hoogendijk , Dorly J.H. Deeg , Marjolein Visser , Kaisa Koivunen , Martijn Huisman , Natasja M. van Schoor","doi":"10.1016/j.exger.2024.112599","DOIUrl":"10.1016/j.exger.2024.112599","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization has introduced the construct of intrinsic capacity (IC) as an important component of healthy ageing and overall well-being in older adults The present study aimed to develop domain-specific and composite IC scores and to validate these scores by examining their longitudinal relation with functioning.</div></div><div><h3>Methods</h3><div>We used prospective data on participants aged 57 to over 90 years, with a 10-year follow-up, from the Longitudinal Aging Study Amsterdam, an ongoing cohort study of older Dutch men and women Using a formative, stepwise approach, we identified indicators across the different domains of IC, i.e. vitality, sensory, cognition, psychology, and locomotion, using a combination of unidimensional factor analyses and Partial Least Squares Structural Equation Modelling (PLS-SEM). Next, domain-specific and composite IC scores were generated, and the construct validity (score across age groups) and criterion validity (relationship with change in functional limitations) were assessed.</div></div><div><h3>Results</h3><div>The multiple unidimensional factor analyses and PLS-SEM identified a total of 18 indicators, covering the five domains of IC. The mean composite IC score was 70.9 (SD = 0.9) in men and 69.7 (0.8) in women. The domain-specific and composite IC scores all showed good construct validity, with known-group validation results indicating age-related declines. A higher composite IC score was associated with less functional limitations over time (B = 0.20, 95%CI [0.19, 0.22]).</div></div><div><h3>Conclusion</h3><div>The developed domain-specific IC scores and the composite IC score effectively discriminated age-related declines in IC. Additionally, the composite IC score was longitudinally associated with functional limitations. By creating this comprehensive and reliable tool for tracking IC, we aim to provide valuable insights into the dynamics of ageing and support more effective strategies for promoting health and well-being throughout later life. These scores establish a foundation for future research to track longitudinal changes across various IC domains and relate these changes to key age-related outcomes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112599"},"PeriodicalIF":3.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between nighttime sleep duration and quality with low back pain in middle-aged and older Chinese adults 中国中老年人夜间睡眠时间和质量与腰背痛的关系

IF 3.9

Experimental gerontology

Pub Date : 2024-10-05 DOI: 10.1016/j.exger.2024.112602

Jiju Yang , Cong Liu , Guanwei Wu , Sihao Zhao

Background

This study aims to investigate the association between sleep duration, sleep quality, and the risk of low back pain (LBP) among middle-aged and elderly individuals in China.

Methods

Utilizing data from the China Health and Retirement Longitudinal Study spanning 2011 to 2020, we categorized sleep duration into long, medium, and short categories, and sleep quality into good, fair, and poor levels. LBP status was determined based on self-reported information by participants. Multivariable logistic regression analysis was employed to assess the relationship between sleep duration, sleep quality, with the risk of LBP.

Results

A total of 6750 individuals were included in the longitudinal study. After 9 years of follow-up, the prevalence of LBP was 25.69 %. In the fully adjusted model, compared to individuals with medium sleep duration, those with short sleep duration had a 28 % increased risk of developing LBP (OR = 1.28, 95%CI: 1.12, 1.46). Additionally, when compared to individuals with good sleep quality, those with fair and poor sleep quality had a 35 % (OR = 1.35, 95%CI: 1.19, 1.54) and 33 % (OR = 1.33, 95%CI: 1.12, 1.58) increased risk of LBP, respectively. Joint analysis of both factors revealed that individuals with poor sleep quality and short sleep duration had the highest risk of LBP.

Conclusion

Among middle-aged and elderly individuals in China, short sleep duration and poor sleep quality were associated with an increased risk of LBP. Future studies should further explore the mechanisms underlying this association and validate the findings through randomized controlled trials.

研究背景本研究旨在调查中国中老年人的睡眠时间、睡眠质量与腰背痛（LBP）风险之间的关系：利用中国健康与退休纵向研究（2011-2020 年）的数据，我们将睡眠时间分为长、中、短三类，将睡眠质量分为好、一般、差三级。枸杞多糖症状况则根据参与者的自我报告信息确定。采用多变量逻辑回归分析评估睡眠时间、睡眠质量与枸杞痛风险之间的关系：共有 6750 人参与了这项纵向研究。经过9年的随访，枸杞痛的患病率为25.69%。在完全调整模型中，与睡眠时间中等的人相比，睡眠时间短的人患腰背痛的风险增加了 28%（OR = 1.28，95%CI：1.12, 1.46）。此外，与睡眠质量好的人相比，睡眠质量一般和睡眠质量差的人患腰背痛的风险分别增加了 35% (OR = 1.35, 95%CI: 1.19, 1.54) 和 33% (OR = 1.33, 95%CI: 1.12, 1.58)。对这两个因素的联合分析表明，睡眠质量差和睡眠时间短的人患腰背痛的风险最高：结论：在中国的中老年人中，睡眠时间短和睡眠质量差与枸杞痛风险增加有关。今后的研究应进一步探讨这种关联的机制，并通过随机对照试验验证研究结果。

{"title":"Association between nighttime sleep duration and quality with low back pain in middle-aged and older Chinese adults","authors":"Jiju Yang , Cong Liu , Guanwei Wu , Sihao Zhao","doi":"10.1016/j.exger.2024.112602","DOIUrl":"10.1016/j.exger.2024.112602","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to investigate the association between sleep duration, sleep quality, and the risk of low back pain (LBP) among middle-aged and elderly individuals in China.</div></div><div><h3>Methods</h3><div>Utilizing data from the China Health and Retirement Longitudinal Study spanning 2011 to 2020, we categorized sleep duration into long, medium, and short categories, and sleep quality into good, fair, and poor levels. LBP status was determined based on self-reported information by participants. Multivariable logistic regression analysis was employed to assess the relationship between sleep duration, sleep quality, with the risk of LBP.</div></div><div><h3>Results</h3><div>A total of 6750 individuals were included in the longitudinal study. After 9 years of follow-up, the prevalence of LBP was 25.69 %. In the fully adjusted model, compared to individuals with medium sleep duration, those with short sleep duration had a 28 % increased risk of developing LBP (OR = 1.28, 95%CI: 1.12, 1.46). Additionally, when compared to individuals with good sleep quality, those with fair and poor sleep quality had a 35 % (OR = 1.35, 95%CI: 1.19, 1.54) and 33 % (OR = 1.33, 95%CI: 1.12, 1.58) increased risk of LBP, respectively. Joint analysis of both factors revealed that individuals with poor sleep quality and short sleep duration had the highest risk of LBP.</div></div><div><h3>Conclusion</h3><div>Among middle-aged and elderly individuals in China, short sleep duration and poor sleep quality were associated with an increased risk of LBP. Future studies should further explore the mechanisms underlying this association and validate the findings through randomized controlled trials.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112602"},"PeriodicalIF":3.9,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0