Experimental gerontology最新文献_第9页

Longitudinal changes of sarcopenia status and risks of cardiovascular disease and all-cause mortality 骨骼肌减少症状态与心血管疾病和全因死亡率风险的纵向变化

IF 4.3

Experimental gerontology

Pub Date : 2025-12-08 DOI: 10.1016/j.exger.2025.112989

Kaixin Zhang , Xiaowei Zheng , Tao Ma

Background and objectives

Little is known about the association between changes in sarcopenia status with cardiovascular disease (CVD) and all-cause mortality. We aimed to evaluate the associations between sarcopenia status changes and incident CVD and mortality in a large prospective cohort of middle-aged and older adults.

Methods

A total of 7257 participants from the China Health and Retirement Longitudinal Study 2011 were included in analyses. Sarcopenia status was defined according to the Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria. Cox proportional hazards regression models were used to examine the association of changes in sarcopenia status (never, onset, remitted, and persistent) with CVD (stroke or cardiac events) and all-cause mortality.

Results

During a maximum follow-up period of 2 years, a total of 722 (9.95 %) respondents experienced CVD (303 stroke and 456 cardiac events), and 292 (4.02 %) deaths were identified. Compared to participants without any sarcopenia, those in the improved and persistent sarcopenia had an increased risk of CVD, with multiple-adjusted hazard ratios (95 % confidence intervals) of 1.37 (1.04–1.80) and 1.32 (1.03–1.69), respectively. Individuals with improved and persistent sarcopenia also had higher risk of stroke and cardiac events. Among participants with baseline possible sarcopenia, those who recovered to a non-sarcopenia status had a significantly lower risk of new-onset CVD and stroke, compared to those who remained in the possible sarcopenia status.

Conclusion

Changes in sarcopenia status are associated with varying risks of new-onset CVD risk and all-cause mortality. Monitoring long-term changes in the sarcopenia should prioritize CVD prevention strategies.

背景和目的：关于肌肉减少症与心血管疾病（CVD）和全因死亡率之间的关系，我们知之甚少。我们的目的是评估肌肉减少症状态变化与CVD事件和死亡率之间的关系，在一个大型的中老年前瞻性队列中。方法：2011年中国健康与退休纵向研究共纳入7257名参与者。肌少症状态根据2019年亚洲肌少症工作组（AWGS 2019）标准定义。使用Cox比例风险回归模型来检查肌肉减少症状态（从未、发作、缓解和持续）的变化与CVD（中风或心脏事件）和全因死亡率的关系。结果：在最长2 年的随访期间，共有722名（9.95 %）受访者经历了CVD（303例卒中和456例心脏事件），并确定了292例（4.02 %）死亡。与没有任何肌肉减少症的参与者相比，改善和持续肌肉减少症的参与者患心血管疾病的风险增加，多重校正风险比（95 %置信区间）分别为1.37（1.04-1.80）和1.32（1.03-1.69）。肌肉减少症得到改善和持续的个体也有较高的中风和心脏事件的风险。在基线可能有肌少症的参与者中，那些恢复到非肌少症状态的人与那些仍然处于可能的肌少症状态的人相比，新发心血管疾病和中风的风险显着降低。结论：肌少症状态的改变与不同的新发心血管疾病风险和全因死亡率相关。监测肌肉减少症的长期变化应优先考虑心血管疾病预防策略。

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引用次数: 0

A subtle association raising bigger questions: Implicit and explicit ageism in the Dutch age IAT 一个微妙的联系引发了更大的问题：荷兰时代的隐性和显性年龄歧视。

IF 4.3

Experimental gerontology

Pub Date : 2025-12-08 DOI: 10.1016/j.exger.2025.112988

Belia Schuurman , Jolanda Lindenberg , Tineke A. Abma , Wilco P. Achterberg

This study presents the first baseline analysis of the Dutch Age Implicit Association Test (IAT) data, examining both implicit and explicit ageism measures in the Netherlands. Analyzing data from 8680 participants over a range of 12 years, we investigated implicit ageism scores, their association with explicit ageism measures, and associations with demographic characteristics. Results position the Netherlands in the international midfield for implicit ageism. Significant gender differences emerged, with men showing higher implicit ageism scores than women. We found no significant relationship between age and implicit ageism. The study revealed small to moderate yet significant correlations between implicit and explicit ageism measures, suggesting these are subtly related yet distinct constructs. These findings contribute to the international comparative literature on ageism by establishing a Dutch baseline and emphasize the need for further research into the association between implicit and explicit ageism. To tackle the prevalence and consequences of ageism in our social lives and institutions, the mechanisms underlying age-related biases across different contexts need to be investigated further.

本研究提出了荷兰年龄内隐联想测试（IAT）数据的第一个基线分析，检查了荷兰的内隐和外显年龄歧视措施。我们分析了8680名参与者在12 年的时间里的数据，研究了内隐年龄歧视评分、它们与外显年龄歧视措施的关系，以及它们与人口统计学特征的关系。结果显示，荷兰队因隐性年龄歧视而处于国际中场位置。显著的性别差异出现了，男性的隐性年龄歧视得分高于女性。我们发现年龄与隐性年龄歧视之间没有显著的关系。该研究揭示了内隐和外显年龄歧视测量之间的小到中度但显著的相关性，表明它们是微妙相关但不同的结构。这些发现通过建立荷兰基线，为年龄歧视的国际比较文献做出了贡献，并强调了对内隐和外显年龄歧视之间关系的进一步研究的必要性。为了解决在我们的社会生活和机构中普遍存在的年龄歧视及其后果，需要进一步研究不同背景下与年龄相关的偏见的潜在机制。

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引用次数: 0

Prognostic assessment of sepsis-induced acute respiratory distress syndrome in older patients using clinical and CT-based radiomic features 使用临床和基于ct的放射学特征评估败血症引起的老年患者急性呼吸窘迫综合征的预后。

IF 4.3

Experimental gerontology

Pub Date : 2025-12-05 DOI: 10.1016/j.exger.2025.112987

Xiya Wang , Bowen Zhang , Ying Chen , Xinzhen Gao , Yongshen Bai , Shuxing Wei , Shubin Guo , Xue Mei

Background

Sepsis-induced acute respiratory distress syndrome (SI-ARDS) is associated with high mortality rates, necessitating early risk stratification. This study aimed to develop and validate a radiomics-based nomogram integrating computed tomography (CT) features and clinical parameters to predict 28-day mortality in older patients with SI-ARDS.

Methods

In this retrospective cohort study, 302 older patients (≥60 years) diagnosed with SI-ARDS between January 2019 and December 2023 were enrolled. Radiomic features were extracted from admission chest CT images. Patients were randomly allocated to training (n = 242) and validation (n = 60) cohorts. Three predictive models—radiomic, clinical, and combined—were constructed using Maximum Relevance Minimum Redundancy (MRMR) algorithm and Least Absolute Shrinkage and Selection Operator (LASSO) regression. Model performance was assessed using the concordance index (C-index), calibration curves, and decision curve analysis. A nomogram was developed based on the optimal model for clinical application.

Results

The fusion model achieved superior discrimination compared with the radiomic model, clinical model, and Sequential Organ Failure Assessment score in both cohorts (C-index: training, 0.850 vs. 0.798, 0.781, and 0.654; validation, 0.839 vs. 0.768, 0.779, and 0.696; all p < 0.001). The model demonstrated excellent calibration and provided greater net clinical benefit across threshold probabilities of 10 %–90 %. Risk stratification using the nomogram identified distinct prognostic groups with significantly different 28-day survival (log-rank p < 0.001).

Conclusion

The nomogram developed from the fusion model demonstrated superior predictive performance for 28-day mortality in older patients with SI-ARDS compared to conventional scoring systems, though multicenter validation is required to confirm clinical utility.

背景：败血症引起的急性呼吸窘迫综合征（SI-ARDS）死亡率高，需要进行早期风险分层。本研究旨在开发和验证一种基于放射组学的图，结合计算机断层扫描（CT）特征和临床参数来预测老年SI-ARDS患者的28天死亡率。方法：在这项回顾性队列研究中，纳入了2019年1月至2023年12月期间诊断为SI-ARDS的302例老年患者（≥60 岁）。从入院胸部CT图像中提取放射学特征。患者被随机分配到训练组（n = 242）和验证组（n = 60）。使用最大相关最小冗余（MRMR）算法和最小绝对收缩和选择算子（LASSO）回归构建了放射学、临床和组合三种预测模型。采用一致性指数（C-index）、校准曲线和决策曲线分析来评估模型的性能。在此基础上建立了一种适合临床应用的模式图。结果：在两个队列中，与放射学模型、临床模型和序贯器官衰竭评估评分相比，融合模型取得了更好的识别效果(c指数：训练，0.850比0.798、0.781和0.654；验证，0.839比0.768、0.779和0.696；结论：与传统评分系统相比，融合模型开发的nomogram对SI-ARDS老年患者28天死亡率的预测能力更强，但需要多中心验证来证实其临床实用性。

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引用次数: 0

Copper-to-zinc ratio predicts incident sarcopenia and adverse health outcomes: Results from I-Lan Longitudinal Aging Study 铜锌比预测肌肉减少症和不良健康结果：来自宜兰纵向衰老研究的结果。

IF 4.3

Experimental gerontology

Pub Date : 2025-12-01 DOI: 10.1016/j.exger.2025.112984

Kuan-Yu Peng , Wei-Ju Lee , Chih-Kuang Liang , Li-Ning Peng , Ming-Hsien Lin , Ching-Hui Loh , Fei-Yuan Hsiao , Liang-Kung Chen

Introduction

The copper-to‑zinc (Cu/Zn) ratio is linked to inflammation and aging, but longitudinal evidence for sarcopenia remains limited. We examined associations of serum copper (Cu), zinc (Zn), and Cu/Zn ratio with adverse health outcomes and sarcopenia.

Methods

Cu, Zn, and the Cu/Zn ratio were analyzed as continuous variables and by tertiles. The study included (1) a 5-year survival analysis assessing associations with adverse outcomes (falls, hospital admissions, emergency department visits, mortality, and a composite outcome); and (2) cross-sectional and 3-year longitudinal analysis examining their associations with prevalent and incident sarcopenia. Sarcopenia was defined based on the Asian Working Group for Sarcopenia 2019 criteria.

Results

Over five years, 357 of 2015 participants experienced adverse events; 311 of 1474 non-sarcopenic participants developed incident sarcopenia over three years. Each standard deviation increase in the Cu/Zn ratio was associated with higher risks of adverse outcomes (aHR 1.18, 95 % CI 1.04–1.33, p = 0.008), hospitalization (aHR 1.23, 95 % CI 1.02–1.49, p = 0.030), mortality (aHR 1.50, 95 % CI 1.06–2.13, p = 0.021), and incident sarcopenia (aOR 1.39, 95 % CI 1.13–1.73, p < 0.001). Higher Cu levels predicted low muscle mass (aOR 1.18, 95 % CI 1.05–1.33, p = 0.005), while higher Zn levels were protective against muscle weakness (aOR 0.84, 95 % CI 0.73–0.97, p = 0.015). Importantly, the association between the Cu/Zn ratio and incident sarcopenia remained significant after additional adjustment for cardiometabolic risk factors and inflammatory biomarkers.

Conclusions

Elevated serum Cu/Zn ratio predicts adverse outcomes and sarcopenia, highlighting its value as a biomarker for clinical risk in older adults.

铜锌比（Cu/Zn）与炎症和衰老有关，但骨骼肌减少症的纵向证据仍然有限。我们研究了血清铜（Cu）、锌（Zn）和铜/锌比与不良健康结果和肌肉减少症的关系。方法：以Cu、Zn、Cu/Zn比为连续变量，采用分位数法进行分析。该研究包括(1)5年生存分析，评估与不良结果（跌倒、住院、急诊就诊、死亡率和综合结果）的关联；(2)横断面和3年的纵向分析，检查它们与普遍和偶然的肌肉减少症的关系。肌少症是根据2019年亚洲肌少症工作组的标准定义的。结果：在5年多的时间里，2015名参与者中有357人经历了不良事件；在1474名非肌少症参与者中，有311人在三年内发生了肌少症。每个标准偏差增加铜/锌比值与更高风险的不良结果(aHR 1.18, 95 %可信区间1.04 - -1.33,p = 0.008),住院治疗(aHR 1.23, 95 %可信区间1.02 - -1.49,p = 0.030),死亡率(aHR 1.50, 95 %可信区间1.06 - -2.13,p = 0.021),和事件sarcopenia(优势比1.39,95 %可信区间1.13 - -1.73,p 结论:升高血清铜/锌比值预测不良结果sarcopenia,突出它的价值作为一个生物标志物在老年人临床风险。

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引用次数: 0

Life after migration: A comparative study on successful aging in India 移民后的生活：印度成功老龄化的比较研究。

IF 4.3

Experimental gerontology

Pub Date : 2025-12-01 DOI: 10.1016/j.exger.2025.112966

Bittu Mandal , Kalandi Charan Pradhan , Arun Balachandran

Understanding the dynamics of successful aging in India is crucial, especially in the context of a rising aging population. India, being home to one of the largest internal migrant population in the world, presents a unique context to examine how migration influences aging outcomes. This study investigates disparities in successful aging outcomes between migrant and non-migrant populations in India. Utilizing the Longitudinal Aging Study in India data (n = 23,690), it focuses on the impact of migration status, regional variations, and early life socio-economic and health conditions on aging. Logistic regression, propensity score matching and Blinder-Oaxaca decomposition are employed to explore the association between migration and successful aging. Results reveal significant disparities, with migrants less likely to achieve successful aging, particularly those from lower socio-economic backgrounds. Significant regional disparities and varied childhood socio-economic and health effects highlight the complex interplay between migration and socio-economic status in shaping successful aging trajectories in India. This study provides the first nationally representative evidence from India linking migration and aging, grounded in the Cumulative Inequality framework. The findings emphasize the need for migrant-inclusive aging and health policies, particularly improving portability of social protection, strengthening community-based care, and addressing gendered vulnerabilities to promote equitable and successful aging.

了解印度成功老龄化的动态至关重要，特别是在人口老龄化日益严重的背景下。印度是世界上最大的内部移民人口之一，为研究移民如何影响老龄化结果提供了一个独特的背景。本研究调查了印度移民和非移民人口在成功老龄化结果方面的差异。利用纵向老龄化研究在印度的数据（n = 23,690），它侧重于移民身份，区域差异和早期生活的社会经济和健康状况对老龄化的影响。采用Logistic回归、倾向评分匹配和Blinder-Oaxaca分解等方法探讨移民与成功老龄化之间的关系。结果显示了显著的差异，移民实现成功老龄化的可能性较小，特别是那些社会经济背景较低的移民。重大的区域差异和不同的儿童社会经济和健康影响突出表明，在塑造印度成功的老龄化轨迹方面，移徙与社会经济地位之间存在复杂的相互作用。本研究在累积不平等框架的基础上，提供了印度第一个将移民与老龄化联系起来的具有全国代表性的证据。调查结果强调需要制定包容移民的老龄化和卫生政策，特别是改善社会保护的可移植性，加强社区护理，解决性别脆弱性问题，以促进公平和成功的老龄化。

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引用次数: 0

Plasma Alzheimer's biomarkers and physical functions in aging adults with and without motoric cognitive risk syndrome 血浆阿尔茨海默病的生物标志物和老年人的身体功能，有和没有运动认知风险综合征

IF 4.3

Experimental gerontology

Pub Date : 2025-12-01 DOI: 10.1016/j.exger.2025.112975

Pei-Hao Chen , Sang-I Lin , Ying-Yi Liao , Gwo-Chi Hu , Fang-Yu Cheng

Background

Mobility impairments such as slowed gait and diminished functional capacity are increasingly recognized as early indicators of neurodegenerative processes in aging, including Alzheimer's disease. While cerebrospinal fluid and imaging biomarkers have shown links to physical decline, blood-based biomarkers offer a less invasive and more scalable alternative. However, their associations with physical performance across different stages of cognitive aging remain insufficiently explored. This study aimed to examine the cross-sectional associations between plasma amyloid beta 42 and total tau levels and physical function in older adults with normal cognition, motoric cognitive risk syndrome, and mild Alzheimer's disease.

Methods

A total of 159 community-dwelling older adults were enrolled and categorized into three cognitive groups. Plasma biomarker levels were measured using immunomagnetic reduction assays. Physical function was assessed using gait speed, Timed Up and Go, tandem stance, and dual-task walking. Generalized linear models were applied to assess associations between biomarkers and performance within each group.

Results

Higher plasma amyloid beta 42 levels were significantly associated with poorer Timed Up and Go performance in the full sample and in those with motoric cognitive risk syndrome. Unexpectedly, higher plasma total tau levels were positively associated with gait speed in the motoric cognitive risk group. No significant associations were observed for balance or dual-task performance.

Conclusion

Plasma biomarkers may reflect stage-specific mobility changes in aging populations. Their integration with performance-based tests may support early identification of functional decline and guide timely interventions.

活动障碍，如步态缓慢和功能能力下降，越来越多地被认为是老年神经退行性过程的早期指标，包括阿尔茨海默病。虽然脑脊液和成像生物标志物显示出与身体衰退有关，但基于血液的生物标志物提供了一种侵入性更小、更可扩展的替代方法。然而，它们与认知衰老不同阶段的身体表现之间的关系仍未得到充分探讨。本研究旨在研究血浆淀粉样蛋白β 42和总tau水平与正常认知、运动认知风险综合征和轻度阿尔茨海默病老年人身体功能之间的横断面关联。方法对159名居住在社区的老年人进行研究，并将其分为三个认知组。采用免疫磁还原法测定血浆生物标志物水平。身体功能通过步态速度、计时起身和行走、串联站立和双任务行走来评估。应用广义线性模型来评估每组生物标志物与表现之间的关系。结果血浆淀粉样蛋白β 42水平升高与全样本和运动认知风险综合征患者较差的Timed Up和Go表现显著相关。出乎意料的是，在运动认知风险组中，较高的血浆总tau水平与步态速度呈正相关。在平衡或双任务表现方面没有观察到显著的关联。结论血浆生物标志物可反映老年人群不同阶段的流动性变化。它们与基于表现的测试相结合，可能有助于早期识别功能衰退，并指导及时干预。

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引用次数: 0

The interactive influences of sleep duration and activities of daily living on low back pain: Insights from CHARLS 睡眠时间和日常生活活动对腰痛的交互影响：CHARLS的见解。

IF 4.3

Experimental gerontology

Pub Date : 2025-12-01 DOI: 10.1016/j.exger.2025.112986

Yang Xu , Fei Jiang , Bin Zheng , Guang-Lei Zhang , Ren-Hu Li

Objectives

To quantify interactions between sleep duration and activities of daily living (ADL) limitations on low back pain (LBP) in Chinese adults ≥45 years using China Health and Retirement Longitudinal Study (CHARLS) data.

Methods

This study presents a cross-sectional analysis of CHARLS data collected between 2011 and 2015. Participants self-reported their sleep duration and LBP experiences. ADL limitations were assessed using a 12-item scale. Logistic regression analysis was used to evaluate the interaction effects of sleep duration and ADL limitations on LBP.

Results

Short sleep (OR = 1.50, 95 % CI 1.32, 1.70), basic activities of daily living (BADL) limitation (OR = 2.22, 95 % CI 1.68, 2.95), and instrumental activities of daily living (IADL) limitation (OR = 2.01, 95 % CI 1.72, 2.36) were independently associated with LBP. Multiplicative interactions were significant for short sleep with BADL (OR = 3.03, 95 % CI 1.97, 4.67) and IADL (OR = 1.94, 95 % CI 1.53, 2.45), and for long sleep with BADL (OR = 2.54, 95 % CI 1.41, 4.56) and IADL (OR = 1.62, 95 % CI 1.20, 2.18). Additive synergy was found in adults ≥60 years with short sleep and BADL (RERI = 2.81, AP = 0.56, S = 3.32), while long sleep and IADL showed antagonism (RERI = -1.30, AP = -0.68, S = 0.41).

Conclusion

In adults ≥60 years, short sleep combined with BADL limitation exhibits an additive interaction on LBP, while long sleep combined with IADL limitation shows antagonism. Therefore, longitudinal studies are needed for causality and targeted interventions.

目的：利用中国健康与退休纵向研究（CHARLS）数据，量化≥45 岁中国成年人睡眠时间与日常生活活动（ADL）限制腰痛（LBP）之间的相互作用。方法：对2011 - 2015年CHARLS数据进行横断面分析。参与者自我报告了他们的睡眠时间和腰痛经历。使用12项量表评估ADL限制。采用Logistic回归分析评估睡眠时间和ADL限制对LBP的交互作用。结果:短睡眠(或 = 1.50,1.32 95 % CI, 1.70),基本日常生活活动(BADL)限制(或 = 2.22,1.68 95 % CI, 2.95),和工具性日常生活活动(IADL)限制(或 = 2.01,1.72 95 % CI, 2.36)是独立与LBP有关。乘法交互与BADL显著短睡眠(或 = 3.03,1.97 95 % CI, 4.67)和IADL(或 = 1.94,1.53 95 % CI, 2.45),和长时间的睡眠BADL(或 = 2.54,1.41 95 % CI, 4.56)和IADL(或 = 1.62,1.20 95 % CI, 2.18)。添加剂协同作用被发现在成年人≥60 年短睡眠和BADL (RERI = 2.81,美联社 = 0.56,3.32 S = ),而长时间睡眠和IADL显示对抗(RERI = -1.30,美联社 = -0.68 S = 0.41)。结论：在≥60 岁的成年人中，短睡眠合并BADL限制对LBP表现出加性相互作用，而长睡眠合并IADL限制对LBP表现出拮抗作用。因此，需要对因果关系和有针对性的干预进行纵向研究。

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引用次数: 0

High Torque teno virus viremia predicts long-term mortality and reflects chronic low-grade inflammation (inflammaging) in geriatric inpatients 高扭矩病毒血症可预测老年住院患者的长期死亡率并反映慢性低度炎症（炎症）。

IF 4.3

Experimental gerontology

Pub Date : 2025-12-01 DOI: 10.1016/j.exger.2025.112978

Laura Cianfruglia , Gretta Veronica Badillo Pazmay , Carlo Fortunato , Pietro Giorgio Spezia , Federica Novazzi , Francesco Piacenza , Marco Malavolta , Francesca Marchegiani , Rina Recchioni , Giulia Matacchione , Chiara Giordani , Maurizio Cardelli , Tiziana Casoli , Mirko Di Rosa , Antonio Cherubini , Giuseppe Pelliccioni , Riccardo Sarzani , Francesco Spannella , Fabrizia Lattanzio , Anna Rita Bonfigli , Robertina Giacconi

Torque teno virus (TTV) is a ubiquitous virus whose viremia increases in conditions of immune dysfunction and aging, suggesting its potential role as a biomarker of immunosenescence. This study investigated the association between TTV viremia and all-cause mortality risk over seven years in a hospitalized older cohort, and its relationship with inflammatory markers including osteopontin (OPN) and growth differentiation factor 15 (GDF15). Data from 956 patients were analyzed, with high TTV load defined as ≥5 log DNA copies/mL. High TTV viremia was significantly associated with increased mortality risk at 1, 3, and 7 years independently of age, sex, comorbidities, and inflammatory markers. In stratified analyses, this association was significant at one year in both males and females, but persisted at three and seven years only in males. The strongest association was observed in participants aged 80–89 years, remaining significant across all follow-up periods. When patients were stratified by a composite immune score reflecting degrees of immunosenescence, high TTV viremia predicted increased mortality among those with intermediate or severe immune dysfunction, persisting up to seven years in the most immunosenescent subgroup. Patients with elevated TTV loads exhibited increased erythrocyte sedimentation rate (ESR), decreased serum albumin and hemoglobin, and significantly higher plasma levels of OPN and GDF15, whereas IL-10 tended to decrease. No significant differences were observed for neutrophil-to-lymphocyte ratio, IL-6, CD163, CCL22, or CXCL9 between high and low TTV viremia groups. These findings indicate that high TTV viremia independently predicts mortality risk and reflects a pro-inflammatory and immunosenescent state.

TTV是一种普遍存在的病毒，其病毒血症在免疫功能障碍和衰老的情况下增加，提示其作为免疫衰老的生物标志物的潜在作用。本研究调查了7年住院老年队列中TTV病毒血症与全因死亡风险之间的关系，及其与骨桥蛋白（OPN）和生长分化因子15 （GDF15）等炎症标志物的关系。分析了956例患者的数据，高TTV负荷定义为≥5 log DNA拷贝/mL。高TTV病毒血症与1、3和7 岁时死亡风险增加显著相关，与年龄、性别、合并症和炎症标志物无关。在分层分析中，这种关联在男性和女性一岁时都很显著，但仅在男性3岁和7岁时持续存在。在80-89岁 岁的参与者中观察到最强的关联，在所有随访期间都保持显著。当用反映免疫衰老程度的综合免疫评分对患者进行分层时，高TTV病毒血症预示着中度或重度免疫功能障碍患者的死亡率增加，在最免疫衰老亚组中持续长达7年。TTV负荷升高的患者表现为红细胞沉降率（ESR）升高，血清白蛋白和血红蛋白降低，血浆OPN和GDF15水平显著升高，而IL-10趋于降低。中性粒细胞与淋巴细胞比率、IL-6、CD163、CCL22或CXCL9在高、低TTV病毒血症组之间无显著差异。这些发现表明，高TTV病毒血症独立预测死亡风险，并反映了促炎和免疫衰老状态。

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引用次数: 0

Associations between sleep duration trajectories and sarcopenia among middle-aged and older Chinese adults 中国中老年人睡眠时间轨迹与肌肉减少症之间的关系。

IF 4.3

Experimental gerontology

Pub Date : 2025-12-01 DOI: 10.1016/j.exger.2025.112972

Wanli Deng , Changqing Li , Xiaojiang Zhao

Background

The association between a single time-point measurement of sleep duration and sarcopenia has been extensively explored in existing literature. However, the potential link between sleep duration trajectories and sarcopenia remains largely unexplored. This study aims to assess the relationship between sleep duration trajectories and sarcopenia within a longitudinal cohort of middle-aged and older Chinese individuals.

Methods

This study analyzed a substantial cohort of participants (n = 6305), aged 45 to 80, drawn from the China Longitudinal Study of Health and Retirement (CHARLS). Sleep duration data, collected at intervals from 2011 to 2015, were employed to plot sleep duration trajectories using group-based trajectory modeling (GBTM). Sarcopenia was assessed utilizing data from 2015. Subsequently, a multivariable logistic regression model was applied to investigate the association between varying sleep duration trajectories and the risk of sarcopenia.

Results

Four distinct trajectories of sleep duration were identified: Class 1, characterized by persistently long sleep duration (n = 1391, 22.06 %); Class 2, characterized by persistently high-normal sleep duration (n = 2129, 33.77 %); Class 3, characterized by persistently low-normal sleep duration (n = 1401, 22.22 %); and Class 4, characterized by persistently short sleep duration (n = 1384, 21.95 %). In the model 0, both persistently long sleep duration (OR: 1.83, 95 % CI: 1.50–2.24; p < 0.001) and persistently short sleep duration (OR: 1.76, 95 % CI: 1.44–2.15; p < 0.001) were notably correlated with a greater risk of sarcopenia when compared to persistently high-normal sleep duration. Furthermore, the stratified analyses generally corroborated the primary findings.

Conclusions

Both persistently long and short sleep duration trajectories are associated with an elevated risk of sarcopenia, compared to persistently high-normal sleep duration trajectories among middle-aged and older Chinese adults. Furthermore, the findings highlight the essential need to monitor changes in sleep duration over time.

背景：现有文献对单时间点睡眠时间测量与肌肉减少症之间的关系进行了广泛的探讨。然而，睡眠时间轨迹和肌肉减少症之间的潜在联系在很大程度上仍未被探索。本研究旨在评估中国中老年个体的睡眠持续时间轨迹与肌肉减少症之间的关系。方法：本研究分析了来自中国健康与退休纵向研究（CHARLS）的45至80岁的大量参与者（n = 6305）。从2011年到2015年每隔一段时间收集一次睡眠持续时间数据，使用基于组的轨迹建模（GBTM）绘制睡眠持续时间轨迹。利用2015年的数据评估肌肉减少症。随后，应用多变量逻辑回归模型来研究不同睡眠时间轨迹与肌肉减少症风险之间的关系。结果：确定了四种不同的睡眠时间轨迹：1类，其特征是持续较长的睡眠时间（n = 1391,22.06 %）；2类，以持续高正常睡眠时间为特征（n = 2129,33.77 %）；第三类，以持续低正常睡眠时间为特征（n = 1401,22.22 %）；第4类以持续短睡眠时间为特征（n = 1384,21.95 %）。在模型0中，持续的长睡眠时间（OR: 1.83, 95 % CI: 1.50-2.24; p ）结论：与中国中老年成年人持续的高正常睡眠时间轨迹相比，持续的长睡眠时间轨迹和短睡眠时间轨迹都与肌肉减少症的风险增加有关。此外，研究结果强调了监测睡眠时间变化的必要性。

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引用次数: 0

Corrigendum to “Regulatory mechanisms of transforming growth factor-β in senescence of fibroblast associated with refractory skin diseases” [Exp. Gerontol. Volume 211, November 2025, 112900] “转化生长因子-β在与难治性皮肤病相关的成纤维细胞衰老中的调节机制”的更正[j] .老年医学杂志。卷211，十一月2025,112900]。

IF 4.3

Experimental gerontology

Pub Date : 2025-12-01 DOI: 10.1016/j.exger.2025.112934

Yujie Zheng , Jindi Lei , An Zhang , Cheng Cao , Aie Xu , Miaoni Zhou , Fuquan Lin

引用次数: 0