Experimental gerontology最新文献_第9页

Cost-effectiveness of a multicomponent training programme for older adults with decreased functional capacity: An economic evaluation 功能能力下降的老年人多成分训练计划的成本效益：经济评估。

IF 4.3

Experimental gerontology

Pub Date : 2025-09-25 DOI: 10.1016/j.exger.2025.112911

J. Subías-Perié , D. Navarrete-Villanueva , A.I. Fernández-García , A. Moradell , J.T. Alcalá-Nalvaiz , E.J. Groessl , I. Ara , S. Vila-Maldonado , J. Pérez-Gómez , M. Gonzalez-Gross , A. Gómez-Cabello , G. Vicente-Rodríguez , J.A. Casajús

Purpose

This study aimed to (I) examine the resources required to implement a multicomponent training (MCT) programme, (II) assess its impact on health care utilisation cost, and (III) evaluate its cost-effectiveness in older adults with decreased functional capacity.

Methods

A total of 123 older adults (mean age: 80.3 ± 5.9 years) were allocated into a control (CON, n = 64) or training group (TRAIN, n = 59). The TRAIN group performed a 6-month MCT programme, which included aerobic exercise, resistance training, flexibility and balance components, while the CON group continued with their usual care. Functional capacity, frailty and health-related quality of life (HRQoL) were assessed at three different timepoints using the Short Physical Performance Battery (SPPB), Frailty Phenotype of Fried and the EuroQol-5D (EQ-5D), respectively. Primary outcome measures included the costs of delivering the MCT, health care utilisation, quality-adjusted life-years (QALYs), and the incremental cost effectiveness ratio (ICER). Analyses were conducted from a health system perspective with a 6-month time horizon.

Results

While no significant changes were observed in the CON group, the TRAIN group showed improvements in SPPB (+3.38 ± 1.32), HRQoL (+0.07 ± 0.12), and frailty (−0.64 ± 1.06) (all p < 0.05). The average cost per TRAIN participant was €164. Health care utilisation cost was lower for TRAIN compared to CON (€3091 and €4135, respectively). The ICERs were €115/point increase in SPPB and €407/point reduction in frailty score. The cost per QALY gained by the TRAIN participant relative to the usual care cost was €6274. At a willingness-to-pay threshold of €49,000/QALY (Spanish Health System), the probability of the exercise intervention being cost-effective was 100 %.

Conclusions

The 6-month Exernet-Elder 3.0 training programme demonstrated an ICER of €115 per SPPB point gained, €407 per point of frailty reduction, and €6274 per QALY gained. The intervention was low-cost (€164 per participant) and produced clinically meaningful improvements in functional capacity, HRQoL, and frailty. These findings underscore the importance of integrating a structured, group-based exercise programmes into public health strategies to address the growing socioeconomic and health burden associated with ageing populations.

Trial registration

ClinicalTrial.gov identifier: NCT03831841

Date of registration

6/02/2019 (Last update 02/07/2020).

目的：本研究旨在(I)检查实施多成分培训（MCT）计划所需的资源，（II）评估其对医疗保健利用成本的影响，以及（III）评估其在功能能力下降的老年人中的成本效益。方法：将123名老年人（平均年龄：80.3 ± 5.9 岁）分为对照组（n = 64）和训练组（n = 59）。TRAIN组进行了为期6个月的MCT计划，其中包括有氧运动，阻力训练，柔韧性和平衡成分，而CON组继续他们的常规护理。在三个不同的时间点分别使用短物理性能电池（SPPB）、Fried虚弱表型和EuroQol-5D （EQ-5D）评估功能能力、虚弱和健康相关生活质量（HRQoL）。主要结局指标包括提供MCT的成本、医疗保健利用、质量调整生命年（QALYs）和增量成本效益比（ICER）。从卫生系统角度进行了为期6个月的分析。结果：CON组未观察到显著变化，TRAIN组在SPPB（+3.38 ± 1.32）、HRQoL（+0.07 ± 0.12）和虚弱（-0.64 ± 1.06）（均p ）方面有所改善。结论：6个月的exnet - elder 3.0培训计划显示，每增加SPPB点的ICER为115欧元，每减少虚弱点的ICER为407欧元，每增加QALY点的ICER为6274欧元。干预是低成本的（每位参与者164欧元），并在功能能力、HRQoL和虚弱方面产生了有临床意义的改善。这些发现强调了将有组织的、以群体为基础的锻炼规划纳入公共卫生战略的重要性，以解决与人口老龄化有关的日益严重的社会经济和健康负担。试验注册：ClinicalTrial.gov标识符：NCT03831841注册日期：2019年6月2日（最后更新日期：2020年7月2日）。

{"title":"Cost-effectiveness of a multicomponent training programme for older adults with decreased functional capacity: An economic evaluation","authors":"J. Subías-Perié , D. Navarrete-Villanueva , A.I. Fernández-García , A. Moradell , J.T. Alcalá-Nalvaiz , E.J. Groessl , I. Ara , S. Vila-Maldonado , J. Pérez-Gómez , M. Gonzalez-Gross , A. Gómez-Cabello , G. Vicente-Rodríguez , J.A. Casajús","doi":"10.1016/j.exger.2025.112911","DOIUrl":"10.1016/j.exger.2025.112911","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to (I) examine the resources required to implement a multicomponent training (MCT) programme, (II) assess its impact on health care utilisation cost, and (III) evaluate its cost-effectiveness in older adults with decreased functional capacity.</div></div><div><h3>Methods</h3><div>A total of 123 older adults (mean age: 80.3 ± 5.9 years) were allocated into a control (CON, <em>n</em> = 64) or training group (TRAIN, <em>n</em> = 59). The TRAIN group performed a 6-month MCT programme, which included aerobic exercise, resistance training, flexibility and balance components, while the CON group continued with their usual care. Functional capacity, frailty and health-related quality of life (HRQoL) were assessed at three different timepoints using the Short Physical Performance Battery (SPPB), Frailty Phenotype of Fried and the EuroQol-5D (EQ-5D), respectively. Primary outcome measures included the costs of delivering the MCT, health care utilisation, quality-adjusted life-years (QALYs), and the incremental cost effectiveness ratio (ICER). Analyses were conducted from a health system perspective with a 6-month time horizon.</div></div><div><h3>Results</h3><div>While no significant changes were observed in the CON group, the TRAIN group showed improvements in SPPB (+3.38 ± 1.32), HRQoL (+0.07 ± 0.12), and frailty (−0.64 ± 1.06) (all <em>p</em> < 0.05). The average cost per TRAIN participant was €164. Health care utilisation cost was lower for TRAIN compared to CON (€3091 and €4135, respectively). The ICERs were €115/point increase in SPPB and €407/point reduction in frailty score. The cost per QALY gained by the TRAIN participant relative to the usual care cost was €6274. At a willingness-to-pay threshold of €49,000/QALY (Spanish Health System), the probability of the exercise intervention being cost-effective was 100 %.</div></div><div><h3>Conclusions</h3><div>The 6-month Exernet-Elder 3.0 training programme demonstrated an ICER of €115 per SPPB point gained, €407 per point of frailty reduction, and €6274 per QALY gained. The intervention was low-cost (€164 per participant) and produced clinically meaningful improvements in functional capacity, HRQoL, and frailty. These findings underscore the importance of integrating a structured, group-based exercise programmes into public health strategies to address the growing socioeconomic and health burden associated with ageing populations.</div></div><div><h3>Trial registration</h3><div>ClinicalTrial.gov identifier: NCT03831841</div></div><div><h3>Date of registration</h3><div>6/02/2019 (Last update 02/07/2020).</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112911"},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory mechanisms of transforming growth factor-β in senescence of fibroblast associated with refractory skin diseases 转化生长因子-β在难治性皮肤病相关成纤维细胞衰老中的调控机制

IF 4.3

Experimental gerontology

Pub Date : 2025-09-25 DOI: 10.1016/j.exger.2025.112900

Yujie Zheng , Jindi Lei , An Zhang , Cheng Cao , Aie Xu , Miaoni Zhou , Fuquan Lin

Fibroblasts, critical for skin structure and function via extracellular matrix (ECM) production, undergo senescence linked to ECM changes and inflammation via senescence-associated secretory phenotypes (SASPs). Transforming growth factor (TGF-β), a pleiotropic cytokine, modulates fibroblast function through multiple signaling pathways, inducing cell cycle arrest, oxidative stress, DNA damage, and SASP production. These processes disrupt ECM homeostasis, exacerbate inflammation, and impair tissue repair, contributing to pathological skin changes.

TGF-β induced fibroblast senescence involves multiple mechanisms and pathways. It causes cell cycle arrest by upregulating CDK inhibitors and activating the p53 pathway. TGF-β also promotes oxidative stress-induced senescence by increasing reactive oxygen species (ROS) production, activating pathways like SMAD, and causing DNA damage. In photoaging, UV exposure induces fibroblast senescence via TGF-β related mechanisms, reducing collagen production and increasing MMP levels. TGF-β also suppresses immune cell functions, creating an immunosuppressive microenvironment that accelerates cellular senescence.

In refractory skin diseases like vitiligo, melanoma, and so on, TGF-β plays a complex role. Its abnormal activation drives fibroblast senescence, impacting immune responses and skin structure. However, Maintaining the normal expression of TGF-β preserves ECM homeostasis, promotes collagen synthesis, and reduces inflammatory factor expression. Emerging therapeutic strategies targeting TGF-β signaling show promise. Pharmaceutical agents and phototherapy mitigate senescence by modulating TGF-β pathways and thus suppress ROS, enhancing collagen synthesis. Combined approaches synergistically improve skin repair and elasticity.

In summary, TGF-β significantly regulates fibroblast senescence in refractory skin diseases through various mechanisms and pathways. Its precise modulation could enhance skin repair and anti-aging therapies. However, further research is needed to explore the interactions between anti-aging ingredients and their clinical effects.

成纤维细胞，通过细胞外基质（ECM）的产生对皮肤结构和功能至关重要，经历与ECM变化相关的衰老和通过衰老相关分泌表型（sasp）引起的炎症。转化生长因子（TGF-β）是一种多效性细胞因子，通过多种信号通路调节成纤维细胞的功能，诱导细胞周期阻滞、氧化应激、DNA损伤和SASP的产生。这些过程破坏ECM稳态，加剧炎症，损害组织修复，导致病理性皮肤变化。TGF-β诱导成纤维细胞衰老涉及多种机制和途径。它通过上调CDK抑制剂和激活p53通路导致细胞周期阻滞。TGF-β还通过增加活性氧（ROS）的产生、激活SMAD等通路和引起DNA损伤来促进氧化应激诱导的衰老。在光老化中，紫外线暴露通过TGF-β相关机制诱导成纤维细胞衰老，减少胶原蛋白的产生，增加MMP水平。TGF-β也抑制免疫细胞功能，形成免疫抑制微环境，加速细胞衰老。在白癜风、黑色素瘤等难治性皮肤病中，TGF-β发挥着复杂的作用。它的异常激活驱动成纤维细胞衰老，影响免疫反应和皮肤结构。然而，维持TGF-β的正常表达可保持ECM稳态，促进胶原合成，降低炎症因子表达。针对TGF-β信号的新兴治疗策略显示出希望。药物和光疗通过调节TGF-β通路从而抑制ROS，促进胶原合成来延缓衰老。综合方法协同改善皮肤修复和弹性。综上所述，TGF-β通过多种机制和途径显著调节难治性皮肤病成纤维细胞衰老。它的精确调节可以促进皮肤修复和抗衰老疗法。然而，抗衰老成分之间的相互作用及其临床效果有待进一步研究。

{"title":"Regulatory mechanisms of transforming growth factor-β in senescence of fibroblast associated with refractory skin diseases","authors":"Yujie Zheng , Jindi Lei , An Zhang , Cheng Cao , Aie Xu , Miaoni Zhou , Fuquan Lin","doi":"10.1016/j.exger.2025.112900","DOIUrl":"10.1016/j.exger.2025.112900","url":null,"abstract":"<div><div>Fibroblasts, critical for skin structure and function via extracellular matrix (ECM) production, undergo senescence linked to ECM changes and inflammation via senescence-associated secretory phenotypes (SASPs). Transforming growth factor (TGF-β), a pleiotropic cytokine, modulates fibroblast function through multiple signaling pathways, inducing cell cycle arrest, oxidative stress, DNA damage, and SASP production. These processes disrupt ECM homeostasis, exacerbate inflammation, and impair tissue repair, contributing to pathological skin changes.</div><div>TGF-β induced fibroblast senescence involves multiple mechanisms and pathways. It causes cell cycle arrest by upregulating CDK inhibitors and activating the p53 pathway. TGF-β also promotes oxidative stress-induced senescence by increasing reactive oxygen species (ROS) production, activating pathways like SMAD, and causing DNA damage. In photoaging, UV exposure induces fibroblast senescence via TGF-β related mechanisms, reducing collagen production and increasing MMP levels. TGF-β also suppresses immune cell functions, creating an immunosuppressive microenvironment that accelerates cellular senescence.</div><div>In refractory skin diseases like vitiligo, melanoma, and so on, TGF-β plays a complex role. Its abnormal activation drives fibroblast senescence, impacting immune responses and skin structure. However, Maintaining the normal expression of TGF-β preserves ECM homeostasis, promotes collagen synthesis, and reduces inflammatory factor expression. Emerging therapeutic strategies targeting TGF-β signaling show promise. Pharmaceutical agents and phototherapy mitigate senescence by modulating TGF-β pathways and thus suppress ROS, enhancing collagen synthesis. Combined approaches synergistically improve skin repair and elasticity.</div><div>In summary, TGF-β significantly regulates fibroblast senescence in refractory skin diseases through various mechanisms and pathways. Its precise modulation could enhance skin repair and anti-aging therapies. However, further research is needed to explore the interactions between anti-aging ingredients and their clinical effects.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112900"},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

D-galactose-induced aging and obese conditions contribute to aging and pathologies in dental pulp of male wistar rats d -半乳糖诱导的衰老和肥胖对雄性wistar大鼠牙髓老化和病理有影响。

IF 4.3

Experimental gerontology

Pub Date : 2025-09-22 DOI: 10.1016/j.exger.2025.112907

Savitri Vaseenon , Nattayaporn Apaijai , Wasana Pratchayasakul , Nipon Chattipakorn , Siriporn C. Chattipakorn

Our previous studies demonstrated that both D-galactose (D-gal)-mediated aging and high-fat diet (HF)-promoted obesity trigger inflammation, impair mitochondrial function in heart and brain, and disrupt bone homeostasis. However, the dental pulp pathologies in aging and obesity remain unclear. Insight into pulp biology under systemic conditions may facilitate strategies for maintaining pulp vitality. This study explored the effects of D-gal-mediated aging and HF-promoted obesity and co-administered conditions on aging, inflammation, oxidative stress, mitochondrial dynamics, and cell death in rats' dental pulp. Forty-eight male Wistar rats were randomly allocated to normal diet (ND) or HF. At week 13, each dietary condition was subdivided into four subgroups (n = 6/subgroup). Each subgroup was administered either vehicle (NDV or HFV; 0.9 % normal saline, subcutaneous injection, once daily) or D-gal (NDD or HFD; 150 mg/kg/day, subcutaneous injection, once daily) for four or eight weeks. After euthanasia, rats' dental pulp was gathered. At both time points, HF-fed rats showed insulin-resistance and hypercholesterolemia; D-gal caused only insulin-resistance in ND-fed rats and did not exacerbate metabolic disorder in HF-fed rats. At four weeks, pulpal inflammation was observed in the HFD rats. At eight weeks, dental pulp from NDD and HFV rats exhibited senescence and inflammation, while HFV rats also showed impaired mitophagy and increased apoptosis. The pulpal pathologies were most observed in eight-week HFD rats including senescence, inflammation, oxidative stress, imbalanced mitochondrial dynamics, impaired mitophagy and autophagy, and increased apoptosis. These findings suggest D-gal-mediated aging aggravated senescence and pathologies in dental pulp of obese rats progressively over time.

我们之前的研究表明，d -半乳糖（D-gal）介导的衰老和高脂肪饮食（HF）促进的肥胖都会引发炎症，损害心脏和大脑的线粒体功能，并破坏骨骼稳态。然而，老年和肥胖对牙髓病理的影响尚不清楚。深入了解系统条件下的牙髓生物学可以促进维持牙髓活力的策略。本研究探讨了d -gal介导的衰老和hf促进的肥胖以及共同给药条件对大鼠牙髓衰老、炎症、氧化应激、线粒体动力学和细胞死亡的影响。48只雄性Wistar大鼠随机分为正常饮食组（ND）和HF组（HF）。在第13周，将每种饮食状况再分为4个亚组（n = 6/亚组）。每个亚组分别给药4或8周（NDV或HFV； 0.9% %生理盐水，皮下注射，每日1次）或D-gal （NDD或HFD； 150 mg/kg/天，皮下注射，每日1次）。安乐死后，收集老鼠的牙髓。在这两个时间点，喂食高频饲料的大鼠表现出胰岛素抵抗和高胆固醇血症；D-gal只引起nd喂养大鼠的胰岛素抵抗，而不加剧hf喂养大鼠的代谢紊乱。4周时，HFD大鼠出现牙髓炎症。8周时，NDD和HFV大鼠的牙髓出现衰老和炎症，HFV大鼠的牙髓也出现线粒体自噬受损和细胞凋亡增加。8周HFD大鼠髓质病理表现为衰老、炎症、氧化应激、线粒体动力学失衡、线粒体自噬和自噬功能受损、细胞凋亡增加。这些发现表明，随着时间的推移，d -gal介导的衰老加剧了肥胖大鼠牙髓的衰老和病理。

{"title":"D-galactose-induced aging and obese conditions contribute to aging and pathologies in dental pulp of male wistar rats","authors":"Savitri Vaseenon , Nattayaporn Apaijai , Wasana Pratchayasakul , Nipon Chattipakorn , Siriporn C. Chattipakorn","doi":"10.1016/j.exger.2025.112907","DOIUrl":"10.1016/j.exger.2025.112907","url":null,"abstract":"<div><div>Our previous studies demonstrated that both D-galactose (D-gal)-mediated aging and high-fat diet (HF)-promoted obesity trigger inflammation, impair mitochondrial function in heart and brain, and disrupt bone homeostasis. However, the dental pulp pathologies in aging and obesity remain unclear. Insight into pulp biology under systemic conditions may facilitate strategies for maintaining pulp vitality. This study explored the effects of D-gal-mediated aging and HF-promoted obesity and co-administered conditions on aging, inflammation, oxidative stress, mitochondrial dynamics, and cell death in rats' dental pulp. Forty-eight male Wistar rats were randomly allocated to normal diet (ND) or HF. At week 13, each dietary condition was subdivided into four subgroups (<em>n</em> = 6/subgroup). Each subgroup was administered either vehicle (NDV or HFV; 0.9 % normal saline, subcutaneous injection, once daily) or D-gal (NDD or HFD; 150 mg/kg/day, subcutaneous injection, once daily) for four or eight weeks. After euthanasia, rats' dental pulp was gathered. At both time points, HF-fed rats showed insulin-resistance and hypercholesterolemia; D-gal caused only insulin-resistance in ND-fed rats and did not exacerbate metabolic disorder in HF-fed rats. At four weeks, pulpal inflammation was observed in the HFD rats. At eight weeks, dental pulp from NDD and HFV rats exhibited senescence and inflammation, while HFV rats also showed impaired mitophagy and increased apoptosis. The pulpal pathologies were most observed in eight-week HFD rats including senescence, inflammation, oxidative stress, imbalanced mitochondrial dynamics, impaired mitophagy and autophagy, and increased apoptosis. These findings suggest D-gal-mediated aging aggravated senescence and pathologies in dental pulp of obese rats progressively over time.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112907"},"PeriodicalIF":4.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil-to-lymphocyte ratio in aging: Trends and clinical implications 衰老中的中性粒细胞与淋巴细胞比率：趋势和临床意义

IF 4.3

Experimental gerontology

Pub Date : 2025-09-22 DOI: 10.1016/j.exger.2025.112908

Francisco Alejandro Lagunas-Rangel

The neutrophil-to-lymphocyte ratio (NLR) has emerged as a widely accessible and cost-effective marker of systemic inflammation, derived from routine peripheral blood counts. It has demonstrated clinical relevance across a broad spectrum of conditions, including infections, cardiovascular disease, malignancies, trauma, postoperative complications, and cancer. Aging is associated with a gradual rise in NLR, driven by increasing neutrophil counts and declining lymphocyte numbers, reflecting underlying immunosenescence and systemic inflammation. Elevated NLR in older adults has been linked to greater morbidity and mortality, with higher levels correlating with increased risk, disease severity, and poorer clinical outcomes in age-related conditions. Interestingly, centenarians exhibit a slower age-related increase in NLR compared with non-centenarians, suggesting a more resilient immune system. This narrative review synthesizes current evidence on the trajectory of NLR across the human lifespan and its clinical relevance in the diagnosis, prognosis, and management of selected age-related diseases. Additionally, it explores emerging strategies to mitigate age-related NLR increases, including regular physical activity, targeted dietary interventions, and pharmacological approaches. A deeper understanding of NLR dynamics may inform preventive and therapeutic strategies to enhance health outcomes in aging populations.

中性粒细胞与淋巴细胞比率（NLR）已成为一种广泛可及且具有成本效益的全身性炎症标志物，来源于常规外周血计数。它已在广泛的疾病中显示出临床相关性，包括感染、心血管疾病、恶性肿瘤、创伤、术后并发症和癌症。衰老与NLR的逐渐上升有关，这是由中性粒细胞计数增加和淋巴细胞数量下降所驱动的，反映了潜在的免疫衰老和全身性炎症。老年人NLR升高与更高的发病率和死亡率有关，较高的NLR水平与年龄相关疾病的风险增加、疾病严重程度和较差的临床结果相关。有趣的是，与非百岁老人相比，百岁老人NLR的年龄相关增长速度较慢，这表明他们的免疫系统更具弹性。这篇叙述性综述综合了NLR在整个人类生命周期中的发展轨迹及其在某些年龄相关疾病的诊断、预后和管理中的临床相关性的现有证据。此外，它还探讨了减轻与年龄相关的NLR增加的新兴策略，包括定期的身体活动，有针对性的饮食干预和药物方法。更深入地了解NLR动态可以为预防和治疗策略提供信息，以提高老年人的健康结果。

{"title":"Neutrophil-to-lymphocyte ratio in aging: Trends and clinical implications","authors":"Francisco Alejandro Lagunas-Rangel","doi":"10.1016/j.exger.2025.112908","DOIUrl":"10.1016/j.exger.2025.112908","url":null,"abstract":"<div><div>The neutrophil-to-lymphocyte ratio (NLR) has emerged as a widely accessible and cost-effective marker of systemic inflammation, derived from routine peripheral blood counts. It has demonstrated clinical relevance across a broad spectrum of conditions, including infections, cardiovascular disease, malignancies, trauma, postoperative complications, and cancer. Aging is associated with a gradual rise in NLR, driven by increasing neutrophil counts and declining lymphocyte numbers, reflecting underlying immunosenescence and systemic inflammation. Elevated NLR in older adults has been linked to greater morbidity and mortality, with higher levels correlating with increased risk, disease severity, and poorer clinical outcomes in age-related conditions. Interestingly, centenarians exhibit a slower age-related increase in NLR compared with non-centenarians, suggesting a more resilient immune system. This narrative review synthesizes current evidence on the trajectory of NLR across the human lifespan and its clinical relevance in the diagnosis, prognosis, and management of selected age-related diseases. Additionally, it explores emerging strategies to mitigate age-related NLR increases, including regular physical activity, targeted dietary interventions, and pharmacological approaches. A deeper understanding of NLR dynamics may inform preventive and therapeutic strategies to enhance health outcomes in aging populations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112908"},"PeriodicalIF":4.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor: Specialized large language models with explainability for Alzheimer's disease diagnosis 给编辑的信：专门用于阿尔茨海默病诊断的具有可解释性的大型语言模型。

IF 4.3

Experimental gerontology

Pub Date : 2025-09-18 DOI: 10.1016/j.exger.2025.112905

Mete Ucdal

引用次数: 0

Relationship between stress systems and inflammation in older adults concerned about falling – Findings from the FEARFALL study 担心跌倒的老年人的压力系统和炎症之间的关系——来自FEARFALL研究的发现。

IF 4.3

Experimental gerontology

Pub Date : 2025-09-17 DOI: 10.1016/j.exger.2025.112899

Anja Müller , Robert Kob , Cornel Christian Sieber , Ellen Freiberger , Nicolas Rohleder , Sabine Britting

Concerns about falling (CaF) in older adults are associated with decreased activity and negative health outcomes. The aim of this study was to examine associations between CaF, stress system activity, and low-grade inflammation in community-dwelling older adults.

In the randomized-controlled FEARFALL study, N = 160 older adults (≥70 years) were enrolled (mean age: 79.5; 73.8 % women); data from 102 were analyzed. The Falls Efficacy Scale-International (FES-I), the FES-I Avoidance Behavior (FES-IAB) and Updated Perceived Control over Falling Scale (UP-CoF) were used to assess CaF. Saliva samples were analyzed to determine stress system activity (cortisol, alpha-amylase). Inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6]) were determined in blood.

A higher UP-CoF score was significantly associated with higher individual cortisol values (β = 0.01, 95 %-CI [0.00, 0.01], p = .047) and was marginally associated with a steeper diurnal cortisol decline (p = .059). No significant associations were found between CaF and alpha-amylase or its parameters (AAR, slope, AUCg). IL-6 was significantly associated with age (β = 0.01, 95 %-CI [0.00, 0.01], p = .019) and BMI (β = 0.27, 95 %-CI [0.00, 0.02], p = .004), while CRP also showed a significant association with BMI (β = 0.01, 95 %-CI [0.00, 0.02], p = .004). There were no significant associations between CaF and inflammatory markers.

Perceived control over falls is associated with physiological cortisol dynamics and may play a role in regulating the stress system activity in older adults. These findings show that psychological factors, such as perceived control, may influence stress regulation in older adults.

老年人担心跌倒（CaF）与活动减少和负面健康结果有关。本研究的目的是研究社区居住老年人的CaF、应激系统活性和低度炎症之间的关系。在随机对照的FEARFALL研究中，N = 纳入了160名老年人（≥70 岁）（平均年龄：79.52岁，73.8 %为女性）；分析了102例的数据。采用跌落效能国际量表（FESI）、FES-I回避行为量表（FES-IAB）和更新的跌落量表感知控制量表（UP-CoF）评估CaF。分析唾液样本以确定应激系统活性（皮质醇，α -淀粉酶）。检测血中炎症标志物（c反应蛋白[CRP]、白细胞介素-6 [IL-6]）。较高的UP-CoF评分与较高的个体皮质醇值显著相关（β = 0.01,95 %-CI [0.00; 0.01], p = ）。047)，且与皮质醇日下降幅度较大有轻微关联（p = .059）。CaF与α -淀粉酶或其参数（AAR、slope、AUCg）之间无显著关联。IL-6与年龄显著相关（β = 0.01,95 %-CI [0.00; 0.01], p = ）。019)和BMI(β = 0.27,95 % ci [0.00, 0.02], p = 。004)， CRP与BMI也有显著相关性（β = 0.01,95 %-CI [0.00; 0.02], p = .004）。CaF与炎症标志物之间无显著相关性。对跌倒的感知控制与生理皮质醇动力学有关，并可能在调节老年人的应激系统活动中发挥作用。这些发现表明，心理因素，如感知控制，可能会影响老年人的压力调节。

{"title":"Relationship between stress systems and inflammation in older adults concerned about falling – Findings from the FEARFALL study","authors":"Anja Müller , Robert Kob , Cornel Christian Sieber , Ellen Freiberger , Nicolas Rohleder , Sabine Britting","doi":"10.1016/j.exger.2025.112899","DOIUrl":"10.1016/j.exger.2025.112899","url":null,"abstract":"<div><div>Concerns about falling (CaF) in older adults are associated with decreased activity and negative health outcomes. The aim of this study was to examine associations between CaF, stress system activity, and low-grade inflammation in community-dwelling older adults.</div><div>In the randomized-controlled FEARFALL study, <em>N</em> = 160 older adults (≥70 years) were enrolled (mean age: 79.5; 73.8 % women); data from 102 were analyzed. The Falls Efficacy Scale-International (FES-I), the FES-I Avoidance Behavior (FES-IAB) and Updated Perceived Control over Falling Scale (UP-CoF) were used to assess CaF. Saliva samples were analyzed to determine stress system activity (cortisol, alpha-amylase). Inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6]) were determined in blood.</div><div>A higher UP-CoF score was significantly associated with higher individual cortisol values (<em>β</em> = 0.01, 95 %-CI [0.00, 0.01], <em>p</em> = .047) and was marginally associated with a steeper diurnal cortisol decline (<em>p</em> = .059). No significant associations were found between CaF and alpha-amylase or its parameters (AAR, slope, AUCg). IL-6 was significantly associated with age (<em>β</em> = 0.01, 95 %-CI [0.00, 0.01], <em>p</em> = .019) and BMI (<em>β</em> = 0.27, 95 %-CI [0.00, 0.02], <em>p</em> = .004), while CRP also showed a significant association with BMI (<em>β</em> = 0.01, 95 %-CI [0.00, 0.02], <em>p</em> = .004). There were no significant associations between CaF and inflammatory markers.</div><div>Perceived control over falls is associated with physiological cortisol dynamics and may play a role in regulating the stress system activity in older adults. These findings show that psychological factors, such as perceived control, may influence stress regulation in older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112899"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative impact of body composition from abdominal computed tomography and paraspinal muscle degeneration on subsequent vertebral fracture risk 腹部计算机断层扫描和棘旁肌退变对随后椎体骨折风险的比较影响。

IF 4.3

Experimental gerontology

Pub Date : 2025-09-17 DOI: 10.1016/j.exger.2025.112904

Yuchao Xiong , Wei Guo , Zhiwu Li , Zhiqiong Li , Bohuan Wang , Xuwen Zeng , Fan Xu , Li Wu , Honghong Jiang

Background

Vertebral compression fractures (VCFs) are a growing public health concern, particularly as a complication of osteoporosis, and significantly increase the risk of subsequent VCFs. This study aimed to elucidate the independent contributions of body composition and paraspinal muscle degeneration to subsequent VCFs.

Methods

This retrospective cohort study enrolled patients diagnosed with acute VCF between 2013 and 2022 who met the following criteria: undergoing abdominal computed tomography (CT) within ±7 days of diagnosis and having a clinical follow-up of ≥1 year. These patients were then categorized into subsequent and non-subsequent VCF groups based on fracture occurrence during follow-up. Body composition parameters at the L3 level and across L1-L5, along with paraspinal muscle indices and FI at L4/5, were assessed using automated CT analysis. Univariate and multivariate logistics were used to identify independent predictors of subsequent VCFs.

Results

A total of 96 patients were included, including 21 in the subsequent VCF group and 75 in the non-subsequent VCF group. Multivariate analysis revealed that higher multi-slice fat infiltration (FI) (odds ratio [OR] = 5.26, 95 % confidence interval [CI]: 1.27–21.77, P = 0.02), lower L4/5 multifidus muscle index (MFMI) (OR = 6.32, 95 % CI: 1.61–24.83, P = 0.01), and a history of non-vertebral fractures (OR = 5.47, 95 % CI: 1.09–27.36, P = 0.04) were independent predictors of subsequent VCFs.

Conclusion

This study demonstrates that systemic muscle quality (reflected by muscle FI) and local paraspinal muscle health (specifically MFMI) are independent risk factors for subsequent VCFs, alongside a history of other fractures. These findings underscore the importance of assessing muscle health in the management and prevention of recurrent VCFs.

背景：椎体压缩性骨折（VCFs）是一个日益受到关注的公共卫生问题，特别是作为骨质疏松症的并发症，并显著增加后续VCFs的风险。本研究旨在阐明身体成分和棘旁肌退变对随后的VCFs的独立贡献。方法：本回顾性队列研究纳入2013年至2022年间诊断为急性VCF的患者，符合以下标准：在诊断后±7 天内接受腹部计算机断层扫描（CT），临床随访≥1 年。然后根据随访期间骨折的发生情况将这些患者分为后续和非后续VCF组。使用自动CT分析评估L3水平和L1-L5的身体成分参数，以及L4/5的棘旁肌肉指数和FI。使用单变量和多变量物流来确定后续vcf的独立预测因子。结果：共纳入96例患者，其中后续VCF组21例，非后续VCF组75例。多变量分析显示,高摘要多层脂肪浸润(FI)(优势比[或] = 5.26,95 %可信区间[CI]: 1.27 - -21.77, P = 0.02),降低L4/5 multifidus肌肉指数(MFMI)(或 = 6.32,95 % CI: 1.61 - -24.83, P = 0.01),和历史的据统计有(或 = 5.47,95 % CI: 1.09 - -27.36, P = 0.04)是后续vcf的独立预测指标。结论：本研究表明，全身肌肉质量（由肌肉FI反映）和局部棘旁肌健康（特别是MFMI）与其他骨折史一起是后续vcf的独立危险因素。这些发现强调了评估肌肉健康在管理和预防复发性vcf中的重要性。

{"title":"Comparative impact of body composition from abdominal computed tomography and paraspinal muscle degeneration on subsequent vertebral fracture risk","authors":"Yuchao Xiong , Wei Guo , Zhiwu Li , Zhiqiong Li , Bohuan Wang , Xuwen Zeng , Fan Xu , Li Wu , Honghong Jiang","doi":"10.1016/j.exger.2025.112904","DOIUrl":"10.1016/j.exger.2025.112904","url":null,"abstract":"<div><h3>Background</h3><div>Vertebral compression fractures (VCFs) are a growing public health concern, particularly as a complication of osteoporosis, and significantly increase the risk of subsequent VCFs. This study aimed to elucidate the independent contributions of body composition and paraspinal muscle degeneration to subsequent VCFs.</div></div><div><h3>Methods</h3><div>This retrospective cohort study enrolled patients diagnosed with acute VCF between 2013 and 2022 who met the following criteria: undergoing abdominal computed tomography (CT) within ±7 days of diagnosis and having a clinical follow-up of ≥1 year. These patients were then categorized into subsequent and non-subsequent VCF groups based on fracture occurrence during follow-up. Body composition parameters at the L3 level and across L1-L5, along with paraspinal muscle indices and FI at L4/5, were assessed using automated CT analysis. Univariate and multivariate logistics were used to identify independent predictors of subsequent VCFs.</div></div><div><h3>Results</h3><div>A total of 96 patients were included, including 21 in the subsequent VCF group and 75 in the non-subsequent VCF group. Multivariate analysis revealed that higher multi-slice fat infiltration (FI) (odds ratio [OR] = 5.26, 95 % confidence interval [CI]: 1.27–21.77, <em>P</em> = 0.02), lower L4/5 multifidus muscle index (MFMI) (OR = 6.32, 95 % CI: 1.61–24.83, <em>P</em> = 0.01), and a history of non-vertebral fractures (OR = 5.47, 95 % CI: 1.09–27.36, <em>P</em> = 0.04) were independent predictors of subsequent VCFs.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that systemic muscle quality (reflected by muscle FI) and local paraspinal muscle health (specifically MFMI) are independent risk factors for subsequent VCFs, alongside a history of other fractures. These findings underscore the importance of assessing muscle health in the management and prevention of recurrent VCFs.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112904"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive impairment: The missing link between sarcopenic obesity and functional decline 认知障碍：肌肉减少型肥胖和功能衰退之间缺失的一环。

IF 4.3

Experimental gerontology

Pub Date : 2025-09-15 DOI: 10.1016/j.exger.2025.112895

Esther Hesline Palandi , Amândio de Araújo Sarmento , Muhammad Iqbal Fajri , Asep Setiawan , Gilbert Rely , Ardi Azhar Nampira , Yurika , Zeth Parinding , Erfan Ramadhani

引用次数: 0

A health promotion behavior intervention for migrant older adults: a randomized controlled trial 老年移民健康促进行为干预：一项随机对照试验

IF 4.3

Experimental gerontology

Pub Date : 2025-09-15 DOI: 10.1016/j.exger.2025.112894

Na Zhou, Hailu Wu, Tianle Xiang, Fang Li, Meijuan Cao

Objectives

This study aimed to evaluate the effects of a Behavior Change Wheel (BCW)-based intervention on improving health promotion behaviors, aging perception, family care, and loneliness among migrant older adults.

Methods

This single-blind, randomized controlled trial included 61 migrant older adults (35 females ≥55 years, 26 males ≥60 years) from two community health centers in Huzhou, China. Participants were randomly assigned to the intervention group (n = 30), received a 12-week BCW-based health promotion program targeting capability, opportunity, and motivation via health education, community activities, and family support, or to the control group (n = 31) received routine community care. The outcomes were measured at baseline, week 6, and post-intervention using validated scales.

Results

All participants (n = 61) completed the study. The intervention group showed significantly greater improvements in health promotion behaviors at week 6 (β = 7.99; 95 % CI: 5.86–10.13; p < 0.001) and post-intervention (β = 11.07; 95 % CI: 8.88–13.26; p < 0.001). Similarly, the intervention group exhibited significantly reduced aging perception (β = −4.80; 95 % CI: [−8.10, −1.49]; p = 0.004) and loneliness (β = −2.92; 95 % CI: [−4.74, −1.11]; p = 0.002), along with enhanced family care (β = 1.75; 95 % CI: [0.76, 2.74]; p < 0.001) at post-intervention. All sub-dimensions of health promotion behaviors improved significantly (p < 0.05).

Conclusions

The BCW-based health promotion intervention effectively enhanced the well-being of migrant older adults by addressing their unique needs. The findings highlight the potential of tailored, multidimensional interventions to support this vulnerable population. Future research should explore long-term effects and cost effectiveness for broader implementation.

目的：本研究旨在评估基于行为改变轮（BCW）的干预对改善流动老年人健康促进行为、衰老感知、家庭护理和孤独感的影响。方法：这项单盲、随机对照试验纳入了来自中国湖州两个社区卫生中心的61名流动老年人（35名女性≥55 岁，26名男性≥60 岁）。参与者被随机分配到干预组（n = 30），通过健康教育、社区活动和家庭支持，接受为期12周的以bcw为基础的健康促进计划，目标是能力、机会和动机，或对照组（n = 31）接受常规社区护理。使用有效的量表在基线、第6周和干预后测量结果。结果：所有参与者（n = 61）完成了研究。干预组在第6周健康促进行为的改善显著更大（β = 7.99;95 % CI: 5.86-10.13; p ）结论：基于bcw的健康促进干预通过解决老年人的独特需求，有效地提高了老年人的幸福感。研究结果强调了为支持这一弱势群体而量身定制的多维干预措施的潜力。未来的研究应探索更广泛实施的长期效果和成本效益。

{"title":"A health promotion behavior intervention for migrant older adults: a randomized controlled trial","authors":"Na Zhou, Hailu Wu, Tianle Xiang, Fang Li, Meijuan Cao","doi":"10.1016/j.exger.2025.112894","DOIUrl":"10.1016/j.exger.2025.112894","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the effects of a Behavior Change Wheel (BCW)-based intervention on improving health promotion behaviors, aging perception, family care, and loneliness among migrant older adults.</div></div><div><h3>Methods</h3><div>This single-blind, randomized controlled trial included 61 migrant older adults (35 females ≥55 years, 26 males ≥60 years) from two community health centers in Huzhou, China. Participants were randomly assigned to the intervention group (<em>n</em> = 30), received a 12-week BCW-based health promotion program targeting capability, opportunity, and motivation via health education, community activities, and family support, or to the control group (<em>n</em> = 31) received routine community care. The outcomes were measured at baseline, week 6, and post-intervention using validated scales.</div></div><div><h3>Results</h3><div>All participants (<em>n</em> = 61) completed the study. The intervention group showed significantly greater improvements in health promotion behaviors at week 6 (β = 7.99; 95 % CI: 5.86–10.13; <em>p</em> < 0.001) and post-intervention (β = 11.07; 95 % CI: 8.88–13.26; p < 0.001). Similarly, the intervention group exhibited significantly reduced aging perception (β = −4.80; 95 % CI: [−8.10, −1.49]; <em>p</em> = 0.004) and loneliness (β = −2.92; 95 % CI: [−4.74, −1.11]; <em>p</em> = 0.002), along with enhanced family care (β = 1.75; 95 % CI: [0.76, 2.74]; <em>p</em> < 0.001) at post-intervention. All sub-dimensions of health promotion behaviors improved significantly (<em>p</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>The BCW-based health promotion intervention effectively enhanced the well-being of migrant older adults by addressing their unique needs. The findings highlight the potential of tailored, multidimensional interventions to support this vulnerable population. Future research should explore long-term effects and cost effectiveness for broader implementation.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112894"},"PeriodicalIF":4.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of exercise on gut microbiota in older people with sarcopenia: Study protocol for a randomised controlled trial 运动对老年肌肉减少症患者肠道微生物群的影响：随机对照试验研究方案

IF 4.3

Experimental gerontology

Pub Date : 2025-09-14 DOI: 10.1016/j.exger.2025.112898

Yanqing Ren , Haiyun Fang , Yu Gao , Gonghua Yin , Xiangfeng He , Nan Chen

Background

Sarcopenia is an age-related disease imposing a substantial burden on individuals and healthcare systems. Resistance training (RT) is recommended as the primary non-pharmacological treatment, and Baduanjin (BDJ) has shown positive effects for sarcopenia. However, the mechanisms through which exercise improves sarcopenia remain unclear. Research has suggested that exercise may enhance sarcopenia through the gut–muscle axis. Therefore, the present study aims to evaluate the effects of BDJ-RT on the gut microbiota in older people with sarcopenia, identify potential target microbial taxa and explore related mechanisms.

Methods

In this 12-week randomised, single-blind controlled trial, 30 older people with sarcopenia will be randomly assigned to the BDJ-RT group (n = 15) or control group (n = 15). The BDJ-RT group will undergo BDJ combined with RT, and the control group will receive health education. Muscle mass, strength, physical performance, quality of life, gut microbiota and short-chain fatty acids will be assessed at baseline, post-intervention and follow-up. Potential target gut microbiota related to sarcopenia will be identified through metagenomic sequencing. The identified strains will then be gavaged to sarcopenic mice to evaluate their effects on sarcopenia. Data will be analysed using an intention-to-treat approach.

Discussion

This study will be the first to systematically investigate the effects of BDJ-RT on the gut microbiota in older people with sarcopenia. The findings will provide potential microbial targets and mechanistic insights into the gut–muscle axis underlying exercise-induced improvements in sarcopenia.

Trial registration

This study was registered on the International Traditional Medicine Clinical Trial Registry, with registration number ITMCTR2025000036.

背景：肌肉减少症是一种与年龄相关的疾病，给个人和医疗保健系统带来了沉重的负担。抗阻训练（RT）被推荐为主要的非药物治疗方法，八段金（BDJ）对肌少症有积极的疗效。然而，运动改善肌肉减少症的机制尚不清楚。研究表明，运动可以通过肠道肌肉轴增强肌肉减少症。因此，本研究旨在评估BDJ-RT对老年肌肉减少症患者肠道微生物群的影响，确定潜在的目标微生物群，并探讨相关机制。方法：在这项为期12周的随机单盲对照试验中，30名老年肌肉减少症患者将被随机分配到BDJ-RT组（n = 15）或对照组（n = 15）。BDJ-RT组接受BDJ联合RT，对照组接受健康教育。将在基线、干预后和随访时评估肌肉质量、力量、身体表现、生活质量、肠道微生物群和短链脂肪酸。与肌肉减少症相关的潜在目标肠道微生物群将通过宏基因组测序进行鉴定。然后将鉴定出的菌株灌胃给肌肉减少症小鼠，以评估其对肌肉减少症的影响。数据将采用意向治疗方法进行分析。讨论：这项研究将是第一个系统地研究BDJ-RT对老年肌肉减少症患者肠道微生物群的影响。该研究结果将提供潜在的微生物靶点和肠道肌肉轴的机制，以了解运动诱导的肌肉减少症的改善。试验注册：本研究已在国际传统医学临床试验注册中心注册，注册号为ITMCTR2025000036。

{"title":"Effects of exercise on gut microbiota in older people with sarcopenia: Study protocol for a randomised controlled trial","authors":"Yanqing Ren , Haiyun Fang , Yu Gao , Gonghua Yin , Xiangfeng He , Nan Chen","doi":"10.1016/j.exger.2025.112898","DOIUrl":"10.1016/j.exger.2025.112898","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is an age-related disease imposing a substantial burden on individuals and healthcare systems. Resistance training (RT) is recommended as the primary non-pharmacological treatment, and Baduanjin (BDJ) has shown positive effects for sarcopenia. However, the mechanisms through which exercise improves sarcopenia remain unclear. Research has suggested that exercise may enhance sarcopenia through the gut–muscle axis. Therefore, the present study aims to evaluate the effects of BDJ-RT on the gut microbiota in older people with sarcopenia, identify potential target microbial taxa and explore related mechanisms.</div></div><div><h3>Methods</h3><div>In this 12-week randomised, single-blind controlled trial, 30 older people with sarcopenia will be randomly assigned to the BDJ-RT group (<em>n</em> = 15) or control group (n = 15). The BDJ-RT group will undergo BDJ combined with RT, and the control group will receive health education. Muscle mass, strength, physical performance, quality of life, gut microbiota and short-chain fatty acids will be assessed at baseline, post-intervention and follow-up. Potential target gut microbiota related to sarcopenia will be identified through metagenomic sequencing. The identified strains will then be gavaged to sarcopenic mice to evaluate their effects on sarcopenia. Data will be analysed using an intention-to-treat approach.</div></div><div><h3>Discussion</h3><div>This study will be the first to systematically investigate the effects of BDJ-RT on the gut microbiota in older people with sarcopenia. The findings will provide potential microbial targets and mechanistic insights into the gut–muscle axis underlying exercise-induced improvements in sarcopenia.</div></div><div><h3>Trial registration</h3><div>This study was registered on the International Traditional Medicine Clinical Trial Registry, with registration number ITMCTR2025000036.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112898"},"PeriodicalIF":4.3,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0