Experimental gerontology最新文献

{"title":"Frailty increases depression risk independently of cognitive decline: Insights from Mendelian randomization and cross-sectional analysis","authors":"Wenjie Li ,&nbsp;Qi Tian ,&nbsp;Jingxi Duan ,&nbsp;Xintong Liu ,&nbsp;Jianwei Shou ,&nbsp;Ting Tang ,&nbsp;Weihua Yu ,&nbsp;Yang Lü","doi":"10.1016/j.exger.2024.112603","DOIUrl":"10.1016/j.exger.2024.112603","url":null,"abstract":"<div><h3>Background</h3><div>Frailty, cognitive decline, and depression are common syndromes among the elderly and are closely interconnected. However, it is still unclear whether the impact of frailty on depression depends on the role of cognitive decline.</div></div><div><h3>Method</h3><div>We conducted the Mendelian randomization (MR) analysis based on the instrumental variables (IVs) from the genome-wide association study (GWAS) databases, and we also performed a cross-sectional study consisting of 1362 older adults aged ≥65 for validation.</div></div><div><h3>Results</h3><div>The results of the multivariable MR analysis showed that frailty significantly increased the risk of depression, even after controlling for the influence of cognitive performance. Conversely, after controlling for frailty, the effect of cognitive performance on depression risk was noticeably reduced. In the cross-sectional study, frailty mediated 24.04 % of the relationship between cognition and depression, and cognition mediated 7.63 % of the relationship between frailty and depression.</div></div><div><h3>Conclusions</h3><div>We provide evidence that frailty could increase depression risk independently of cognitive decline. Further research with a larger sample size is necessary.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112603"},"PeriodicalIF":3.9,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs as commonly expressed biomarkers for sarcopenia and frailty: A systematic review","authors":"Hyung Eun Shin ,&nbsp;Jae Young Jang ,&nbsp;Heeeun Jung ,&nbsp;Chang Won Won ,&nbsp;Miji Kim","doi":"10.1016/j.exger.2024.112600","DOIUrl":"10.1016/j.exger.2024.112600","url":null,"abstract":"<div><h3>Background</h3><div>Coexistent sarcopenia and frailty is more strongly associated with adverse health outcomes than each condition alone. As the importance of coexistent sarcopenia and frailty increases, exploring their underlying mechanisms is warranted. Recently, noncoding ribonucleic acids (RNAs) have been suggested as potential biomarkers of sarcopenia and frailty. This systematic review aimed to summarize noncoding RNAs commonly expressed in sarcopenia and frailty, and to search the predicted target genes and biological pathways of them.</div></div><div><h3>Methods</h3><div>We systematically searched the literatures on PubMed, Embase, Cochrane Library, Web of Science, and Scopus for literature published till November 15, 2023. A total of 7,202 literatures were initially retrieved. After de-duplication, 34 studies (26 sarcopenia-related and 8 frailty-related) were full-text reviewed, and 15 studies (11 sarcopenia-related and 4 frailty-related) were finally included.</div></div><div><h3>Results</h3><div>miR-29a-3p, miR-29b-3p, and miR-328 were identified as commonly expressed in same direction in sarcopenia and frailty. These microRNAs (miRNAs), identified in the literature search using PubMed, modulate transforming growth factor-β signaling via extracellular matrix components and calcineurin/nuclear factor of activated T cells 3 signaling via sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase 2a, which are involved in regulating skeletal muscle fibrosis and the growth of slow-twitch muscle fibers, respectively. miR-155-5p, miR-486, and miR-23a-3p were also commonly expressed in two conditions, although in different or conflicting directions.</div></div><div><h3>Conclusion</h3><div>In this systematic review, we highlight the potential of shared miRNAs that exhibit consistent expression patterns as biomarkers for the early diagnosis and progression assessment of both sarcopenia and frailty.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112600"},"PeriodicalIF":3.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenic obesity and osteoporosis: Research progress and hot spots.","authors":"Shangheng Fan, Yulan Cai, Yunqin Wei, Jia Yang, Jianmei Gao, Yan Yang","doi":"10.1016/j.exger.2024.112544","DOIUrl":"10.1016/j.exger.2024.112544","url":null,"abstract":"<p><p>Sarcopenic obesity (SO) and osteoporosis (OP) are associated with aging and obesity. The pathogenesis of SO is complex, including glucolipid and skeletal muscle metabolic disorders caused by inflammation, insulin resistance, and other factors. Growing evidence links muscle damage to bone loss. Muscle-lipid metabolism disorders of SO disrupt the balance between bone formation and bone resorption, increasing the risk of OP. Conversely, bones also play a role in fat and muscle metabolism. In the context of aging and obesity, the comprehensive review focuses on the effects of mechanical stimulation, mesenchymal stem cells (MSCs), chronic inflammation, myokines, and adipokines on musculoskeletal, at the same time, the impact of osteokines on muscle-lipid metabolism were also analyzed. So far, exercise combined with diet therapy is the most effective strategy for increasing musculoskeletal mass. A holistic treatment of musculoskeletal diseases is still in the preliminary exploration stage. Therefore, this article aims to improve the understanding of musculoskeletal -fat interactions in SO and OP, explores targets that can provide holistic treatment for SO combined with OP, and discusses current limitations and challenges. We hope to provide relevant ideas for developing specific therapies and improving disease prognosis in the future.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112544"},"PeriodicalIF":3.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating small non-coding RNA profiling for identification of older adults with low muscle strength and physical performance: A preliminary study","authors":"Hyung Eun Shin ,&nbsp;Chang Won Won ,&nbsp;Miji Kim","doi":"10.1016/j.exger.2024.112598","DOIUrl":"10.1016/j.exger.2024.112598","url":null,"abstract":"<div><h3>Background</h3><div>Small non-coding RNAs (ncRNAs) have recently emerged as potential biomarkers of sarcopenia. However, previous studies have rarely explored the association of small ncRNAs with sarcopenic components, especially muscle strength and physical performance. We aimed to examine circulating small ncRNA profiles to detect low muscle strength and physical performance in older adults.</div></div><div><h3>Methods</h3><div>Ninety-eight older adults were randomly selected from Korean Frailty and Aging Cohort Study and classified into the “Normal,” “Low muscle strength (MS) only,” “Low physical performance (PP) only,” and “Low MS and PP” groups by Asian Working Group for Sarcopenia 2019 criteria. We used high-throughput sequencing to delineate small ncRNA profiles in plasma. Differentially expressed small ncRNAs were analyzed to reveal distinct patterns based on muscle strength and physical performance status.</div></div><div><h3>Results</h3><div>In “Low MS and PP” group, 119 miRNAs, 86 piRNAs, 92 snoRNAs, 106 snRNAs, and 15 tRNAs were differentially expressed compared to “Normal” group (<em>p</em> &lt; 0.05). After Benjamini-Hochberg adjustment, 39 miRNAs, 2 piRNAs, 75 snoRNAs, 48 snRNAs, and 15 tRNAs showed differential expression in “Low MS and PP” group compared to than “Normal” group (adjusted <em>p</em> &lt; 0.05). No significant differences were observed in comparisons between the other groups (adjusted <em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The expression of circulating small ncRNAs were comprehensively characterized, revealing distinct signatures in older adults with both low muscle strength and physical performance compared to normal individuals. Although preliminary, this characterization can advance small ncRNA research on age-related declines in muscle strength and physical performance by providing foundational data for further investigation.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112598"},"PeriodicalIF":3.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mitochondrial function of peripheral blood mononuclear cells in frail older patients","authors":"Tingting Huang ,&nbsp;Li Qin ,&nbsp;Danmei Zhang,&nbsp;Qiangwei Tong,&nbsp;Qianqian Zhu,&nbsp;Guoxian Ding,&nbsp;Juan Liu","doi":"10.1016/j.exger.2024.112594","DOIUrl":"10.1016/j.exger.2024.112594","url":null,"abstract":"<div><h3>Background</h3><div>Frailty increases the incidence of geriatric syndromes and even the risk of death in old adults. However, the diagnostic criteria for frailty are inconsistent because of complex pathological processes and diverse clinical manifestations. To determine the effective biomarker and recognize frail status early, we investigated the correlation of mitochondrial morphology and function of human peripheral blood mononuclear cells (PBMCs) with frailty status in older adults.</div></div><div><h3>Methods</h3><div>This Cross-sectional study followed 393 participants (aged 25–100 years, female 31.04 %) from the First Affiliated Hospital of Nanjing Medical University. The frailty status of subjects was assessed by the physical frailty phenotype (PFP) scale. We analyzed mitochondria functions including mitochondria copy number (mtDNAcn), the mRNA expressions of mitochondrial dynamics-related genes mitofusin 1(MFN1), mitofusin 2(MFN2), optic atrophy protein-1(OPA1), fission protein-1(FIS1) and dynamin-related protein 1(DRP1), mitochondrial oxidative respiration and reactive oxygen species(ROS) levels in PBMCs. Mitochondria morphology, size, and number were observed by transmission electron microscopy (TEM).</div></div><div><h3>Results</h3><div>After adjustment for sex and BMI, mtDNAcn, the mRNA expression of FIS1, mitochondrial respiratory function (proton leak, maximum oxygen consumption, and respiratory reserve) and ROS level were significantly correlated with age (<em>P</em> = 0.031, 0.030, 0.042, 0.003, 0.002, 0.022, respectively). After correcting for age, sex, and BMI, mtDNAcn and the mRNA expression of OPA1 were correlated with 4 m gait speed respectively (<em>P</em> = 0.003, 0.028, respectively). Compared with non-frail people, mtDNAcn, the mRNA expression of MFN1, mitochondrial basal respiration, proton leak, maximum oxygen consumption, ATP production and space capacity were significantly decreased in frail older adults (<em>P</em> = 0.013, 0.036, 0.026, 0.024, 0.012, 0.032, 0.020, respectively). ROS levels were significantly increased in the frail group (<em>P</em> = 0.016). Compared with non-frail people, the number, length, and perimeter, area of mitochondria were reduced in frail group under TEM (all <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Mitochondrial dysfunctions (decreased mtDNAcn, impaired mitochondrial morphology, imbalanced mitochondrial dynamic, impaired mitochondrial respiratory function, and increased ROS levels) were significantly correlated with frail status.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112594"},"PeriodicalIF":3.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic observation and analysis of factors influencing the progression of diabetic retinopathy","authors":"Ying Zhao,&nbsp;Da-chuan Liu","doi":"10.1016/j.exger.2024.112581","DOIUrl":"10.1016/j.exger.2024.112581","url":null,"abstract":"<div><h3>Objective</h3><div>To actively monitor and analyze the factors that affect the advancement of diabetic retinopathy (DR).</div></div><div><h3>Method</h3><div>In this study, we prospectively recruited patients diagnosed with non-proliferative diabetic retinopathy (NPDR) for concurrent monitoring. A total of 75 patients who transitioned from NPDR to proliferative diabetic retinopathy (PDR) comprised the progression group, while 112 NPDR patients who did not develop PDR formed the stable group in a prospective cohort study. Follow-up assessments occurred every six months, and patients were observed continuously over an eight-year period. Clinical parameters from both NPDR and PDR groups were collected to assess the stability of these indicators (with a coefficient of variation [CV] &gt; 5 % indicating instability and CV &lt; 5 % indicating stability).</div></div><div><h3>Results</h3><div>In the NPDR cohort, 80.4 % Control the stability ratio regulation of glycosylated hemoglobin (HbA1c), whereas in the PDR cohort, 80.0 % Control the proportion of instability (<em>P</em> = 0.001); for blood creatinine (Cr), 64.3 % of NPDR patients maintained stable levels, contrasting with 77.3 % of PDR patients with fluctuating levels (<em>P</em> = 0.001). Blood urea nitrogen (BUN) and homocysteine (HCY) control demonstrated instability in both NPDR and PDR groups. Instability in regulating HbA1c, Cr, BUN, and HCY served as independent risk factors for DR progression, with significant associations found between HbA1c CV (HR: 15.586; 95 % CI: 14.205–15.988; <em>p</em> = 0.001), Cr CV (HR: 9.231; 95 % CI: 9.088–10.235; <em>p</em> = 0.005), BUN CV (HR: 3.568; 95 % CI: 3.183–4.367; <em>p</em> = 0.01), and HCY CV (HR: 8.678; 95 % CI: 7.754–8.998；<em>p</em> = 0.003).</div></div><div><h3>Conclusion</h3><div>Inadequate regulation of HbA1c, Cr, BUN, and HCY independently impact the advancement of DR.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112581"},"PeriodicalIF":3.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of age and sex on heart rate variability and cardiometabolic function in healthy adults","authors":"Alaa I. Alyahya ,&nbsp;Sarah J. Charman ,&nbsp;Nduka C. Okwose ,&nbsp;Amy S. Fuller ,&nbsp;Christopher Eggett ,&nbsp;Peter Luke ,&nbsp;Kristian Bailey ,&nbsp;Guy A. MacGowan ,&nbsp;Djordje G. Jakovljevic","doi":"10.1016/j.exger.2024.112591","DOIUrl":"10.1016/j.exger.2024.112591","url":null,"abstract":"<div><div>Heart rate variability (HRV) is a non-invasive measure of cardiac autonomic function. A clearer understanding as to whether resting autonomic function represented by HRV could be associated with changes in peak exercise cardiac function remains unanswered. This study evaluated the effect of age and sex on HRV, cardiometabolic function, and determined the correlation between HRV and cardiac function in healthy individuals. Sixty-eight participants (age range: 19–78 years old, females, <em>n</em> = 28) were recruited. Participants were stratified according to age (younger (&lt;40 years old, <em>n</em> = 43, females, <em>n</em> = 17) and older age groups (&gt;55 years old, <em>n</em> = 25, females, <em>n</em> = 11). Firstly, HRV was measured using non-invasive impedance cardiography method (TaskForce, CNSystems, Graz, Austria) and recorded at rest (supine position) for 30 min. HRV measures included: low frequency (LF) power, high frequency (HF) power (both normalised (nu) and absolute units (ms²)) and LF/HF ratio. Participants then completed a progressive cardiorespiratory exercise test using a semi-recumbent cycle ergometer (Corival, Lode, Groningen, Netherlands) with simultaneous gas exchange measurements (Metalyzer 3B, Cortex, Leipzig, Germany). Cardiac function was represented by peak exercise cardiac power output index (CPO). After controlling for body mass index and physical activity, males had significantly higher mean vales of RR interval than females (males = 1043 ± 165; females = 952 ± 128 ms, <em>p</em> = 0.02). There was no significant main effect of age, sex or their interaction on any of the other HRV measures. In younger and older females, resting RR interval had a significant relationship with peak exercise CPO (young females: <em>r</em> = 0.54, <em>p</em> &lt; 0.05; old females: <em>r</em> = 0.81, <em>p</em> &lt; 0.01). There was also a significant relationship between resting HF power and peak exercise CPO in younger females (<em>r</em> = 0.70, <em>p</em> &lt; 0.01). HRV was not influenced by age but RR interval was associated with peak exercise CPO in females regardless of age, whilst HF power was significantly associated with CPO in younger females only.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112591"},"PeriodicalIF":3.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging impaired locomotor and biochemical activities in Drosophila melanogaster Oregon R (fruit fly) model","authors":"Abdullateef Onoruoiza Yusuf ,&nbsp;Barnabas Danborno ,&nbsp;Zainab M. Bauchi ,&nbsp;Dahiru Sani ,&nbsp;Iliya Shehu Ndams","doi":"10.1016/j.exger.2024.112593","DOIUrl":"10.1016/j.exger.2024.112593","url":null,"abstract":"<div><div>Despite advancements in healthcare and increased lifespan, aging populations face numerous challenges, including declining cognitive function, increased susceptibility to chronic diseases, and reduced quality of life. This study investigated Aging impaired Locomotors and Biochemical Activities in <em>Drosophila melanogaster</em> Oregon R (Fruit Fly) Model with the aim to elucidate the mechanism involved. Adult wild-type <em>Drosophila melanogaster</em> Oregon R was used for this study. Survival assay, antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and malondialdehyde (MDA)) and total protein (TP) concentration were investigated. Data obtained were analyzed using R studio and GraphPad Prism. The result indicated low survival in male flies compared to female flies and the highest survival rate was observed with both flies reared together in the same vial. There was impaired locomotor activity in the flies with age. There was a significant decrease in the level of SOD, CAT, GSH and TP with age with a corresponding significant increase in the level of MDA. This finding demonstrated that locomotor activity decreased with aging with decrease performance index and also established the involvement of oxidation through the activities of antioxidant enzymes in aging; decreased (<em>p</em> &lt; 0.05) concentration of antioxidant enzymes and increased (<em>p</em> &lt; 0.05) lipid peroxidation. Also, it demonstrated that female species had longer lifespan compared to males while co-habiting of male and female species extended lifespan.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112593"},"PeriodicalIF":3.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urolithin A prevents age-related hearing loss in C57BL/6J mice likely by inducing mitophagy","authors":"Sung Il Cho ,&nbsp;Eu-Ri Jo ,&nbsp;Hee Sun Jang","doi":"10.1016/j.exger.2024.112589","DOIUrl":"10.1016/j.exger.2024.112589","url":null,"abstract":"<div><div>Mitochondrial dysfunction with aging is associated with the development of age-related hearing loss. Mitophagy is a cardinal mechanism to maintain a healthy mitochondrial population through the turnover of damaged mitochondria. Declining mitophagy with age causes a buildup of damaged mitochondria, leading to sensory organ dysfunction. The effect of Urolithin A (UA), a mitophagy inducer, was investigated on age-related hearing loss in a mouse model. C57BL/6J mice were treated with UA from 6 to 10 months of age. UA attenuated an auditory brainstem responses (ABR) threshold shift at 8, 16, and 32 kHz frequencies, and improved mitochondrial DNA integrity and ATP production in the cochlea and auditory cortex. The mRNA levels of mitophagy-related genes and protein levels of PINK1, Parkin, BNIP3, and LC3B increased in the cochlea and auditory cortex. The expression of mitophagosomes and mitophagolysosomes in the cochlea, spiral ganglion, auditory cortex, and inferior colliculus increased, together with the expression of Parkin and BNIP3 in the cochlea, spiral ganglion, auditory cortex, and inferior colliculus. These results indicate that UA counteracted mitophagy decline in the auditory system and prevented age-related hearing loss. UA can be used as a potential agent to prevent age-related hearing loss.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112589"},"PeriodicalIF":3.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524002353/pdfft?md5=9b41e98ca366936b355dc7fbde806de5&pid=1-s2.0-S0531556524002353-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The acute effects of coffee ingestion on postural control and physical function in older adults: A randomised crossover trial","authors":"Darren L. Richardson ,&nbsp;Matt Hill ,&nbsp;Jason Tallis ,&nbsp;Lucas Guimaraes Ferreira ,&nbsp;Neil D. Clarke","doi":"10.1016/j.exger.2024.112592","DOIUrl":"10.1016/j.exger.2024.112592","url":null,"abstract":"<div><div>Caffeine consumption can elicit improvements in aspects of physical function in older adults but also, negatively modify standing balance, potentially increasing fall risk. However, balance alterations and changes in physical function induced by commonly consumed caffeine vehicles such as coffee have not been investigated. Therefore, this study investigated coffee ingestion providing 3 mg·kg BW⁻¹ caffeine on balance performance and physical function, in a group of older adults. In a randomised, crossover design, 22 older adults (Male <em>n</em> = 10, Age: 68 ± 6 years) completed bipedal standing balance and physical function assessments (Senior Fitness Test) under one of the following conditions: caffeinated coffee (COF), decaffeinated coffee (DEC), placebo (PLA) or a control (CON) (no fluid ingestion). Centre of pressure (COP) root mean square and power frequency were calculated to characterise postural performance and strategy, respectively. The complexity (i.e., regularity) of the COP signal was also determined by calculating sample entropy. Caffeinated coffee had limited effects on COP outcomes. Frequency of the COP in the anteroposterior direction was greater following COF compared to DEC (<em>P</em> = 0.047;<em>g</em> = 0.29) but there were no statistical differences between COF and PLA or CON (<em>P</em> &gt; 0.05). Furthermore, there were no significant performance differences between any conditions in all tests of physical function (<em>P</em> &gt; 0.05). This suggests that coffee has limited effects on balance performance or physical function but may influence both balance complexity and the strategy utilised to maintain upright stance. Overall, a strong cup of coffee does not significantly influence balance and measures of functional performance in healthy older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112592"},"PeriodicalIF":3.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524002389/pdfft?md5=a2535eb161577535a098754877c08b62&pid=1-s2.0-S0531556524002389-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}