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An Ultrasonic Transceiver for Non-Invasive Intracranial Pressure Sensing 用于非侵入式颅内压力传感的超声波收发器
Pub Date : 2024-10-16 DOI: 10.1109/TBCAS.2024.3481414
Gerald Topalli;Yingying Fan;Matt Y. Cheung;Ashok Veeraraghavan;Mohammad Hirzallah;Taiyun Chi
This paper presents a 9-mW ultrasonic through-transmission transceiver (TRX) for portable, non-invasive intracranial pressure (ICP) sensing. It employs two ultrasound transducers placed at the temporal bone windows to measure changes in the ultrasonic time-of-flight (ToF), based on which the skull expansion and the corresponding ICP waveform are derived. Key components include a high-efficiency Class-DE power amplifier (PA) with 95% efficiency and an output swing of 15.8 $V_{PP}$, along with a successive approximation register (SAR) delay-locked loop (DLL)-based time-to-digital converter (TDC) with 29.8 ps resolution and 122 ns range. Other than electrical characterization, the sensor is validated through two demonstrations using a water tank setup and a human head phantom setup, respectively. It demonstrates a high correlation of $R^{2}=0.93$ with a medical-grade invasive ICP sensor. The proposed system offers high accuracy, low power consumption, and reliable performance, making it a promising solution for real-time, portable, non-invasive ICP monitoring in various clinical settings.
本文介绍了一种用于便携式无创颅内压 (ICP) 检测的 9 mW 超声波穿透式收发器 (TRX)。它采用放置在颞骨窗口的两个超声波传感器来测量超声波飞行时间(ToF)的变化,并在此基础上得出颅骨膨胀和相应的 ICP 波形。主要组件包括一个效率为 95% 的高效 DE 类功率放大器 (PA),输出摆幅为 15.8 VPP,以及一个基于逐次逼近寄存器 (SAR) 的延迟锁定环 (DLL),分辨率为 29.8 ps,量程为 122 ns 的时间数字转换器 (TDC)。除电气特性外,该传感器还分别通过水箱设置和人体头部模型设置进行了两次演示验证。它与医疗级有创 ICP 传感器的相关性高达 R2 = 0.93。该系统具有精度高、功耗低、性能可靠等特点,是在各种临床环境中进行实时、便携、无创 ICP 监测的理想解决方案。
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引用次数: 0
BrainForest: Neuromorphic Multiplier-Less Bit-Serial Weight-Memory-Optimized 1024-Tree Brain-State Classification Processor BrainForest:神经形态乘法器--低比特序列权重--内存优化的 1024 树脑状态分类处理器
Pub Date : 2024-10-16 DOI: 10.1109/TBCAS.2024.3481160
Gerard O’Leary;Jamie Koerner;Mustafa Kanchwala;Jose Sales Filho;Jianxiong Xu;Taufik A. Valiante;Roman Genov
Personalized brain implants have the potential to revolutionize the treatment of neurological disorders and augment cognition. Medical implants that deliver therapeutic stimulation in response to detected seizures have already been deployed for the treatment of epilepsy. These devices require low-power integrated circuits for life-long operation. This constraint impedes the integration of machine-learning driven classifiers that could improve treatment outcomes. This paper introduces BrainForest, a neuromorphic multiplier-less bit-serial weight-memory-optimized brain-state classification processor. The architecture achieves state-of-the-art energy efficiency using two layers of neuron models to implement the spectral and temporal functions needed for classification: 1) resonate-and-fire neurons are used to extract physiological signal band energy EEG biomarkers 2) leaky integrator neurons are used to build multi-timescale representations for classification. Sparse neural model firing activity is used to clock-gate device logic, thereby decreasing power consumption by 93%. An energy-optimized 1024-tree boosted decision forest performs the classification used to trigger stimulation in response to detected pathological brain states. The IC is implemented in 65nm CMOS with state-of-the-art power consumption (best case: 9.6µW, typical: 118µW), achieving a seizure sensitivity of 97.5% with a false detection rate of 2.08 per hour.
个性化脑部植入物有望彻底改变神经系统疾病的治疗方法,并增强认知能力。根据检测到的癫痫发作提供治疗性刺激的医疗植入体已被用于治疗癫痫。这些设备需要低功耗集成电路来实现终身运行。这种限制阻碍了机器学习驱动的分类器的集成,而机器学习驱动的分类器可以改善治疗效果。本文介绍的 BrainForest 是一种神经形态乘法器--无位串行权重内存优化脑状态分类处理器。该架构采用两层神经元模型来实现分类所需的频谱和时间函数,从而实现了最先进的能效:1)共振-发射神经元用于提取生理信号带能量脑电图生物标记;2)泄漏积分器神经元用于建立分类所需的多时间尺度表征。稀疏神经模型的发射活动被用于时钟门器件逻辑,从而将功耗降低了 93%。经过能量优化的 1024 树提升决策森林执行分类,用于根据检测到的大脑病理状态触发刺激。该集成电路采用 65nm CMOS 工艺实现,功耗达到最先进水平(最佳情况:9.6μW,典型情况:118μW),癫痫发作灵敏度达到 97.5%,错误检测率为每小时 2.08 次。
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引用次数: 0
A Memristive Spiking Neural Network Circuit for Bio-inspired Navigation Based on Spatial Cognitive Mechanisms. 基于空间认知机制的生物启发导航记忆性尖峰神经网络电路
Pub Date : 2024-10-15 DOI: 10.1109/TBCAS.2024.3480272
Zhanfei Chen, Xiaoping Wang, Zilu Wang, Chao Yang, Tingwen Huang, Jingang Lai, Zhigang Zeng

Cognitive navigation, a high-level and crucial function for organisms' survival in nature, enables autonomous exploration and navigation within the environment. However, most existing works for bio-inspired navigation are implemented with non-neuromorphic computing. This work proposes a bio-inspired memristive spiking neural network (SNN) circuit for goal-oriented navigation, capable of online decision-making through reward-based learning. The circuit comprises three primary modules. The place cell module encodes the agent's spatial position in real-time through Poisson spiking; the action cell module determines the direction of subsequent movement; and the reward-based learning module provides a bio-inspired learning method adaptive to delayed and sparse rewards. To facilitate practical application, the entire SNN is quantized and deployed on a real memristive hardware platform, achieving about a 21× reduction in energy consumption compared to a typical digital acceleration system in the forward computing phase. This work offers an implementation idea of neuromorphic solution for robotic navigation application in low-power scenarios.

认知导航是生物在自然界中生存的高级关键功能,可实现在环境中的自主探索和导航。然而,大多数现有的生物启发导航工作都是通过非超构计算实现的。本研究提出了一种用于目标导向导航的生物启发记忆尖峰神经网络(SNN)电路,能够通过基于奖励的学习进行在线决策。该电路由三个主要模块组成。位置单元模块通过泊松尖峰实时编码代理的空间位置;动作单元模块决定后续运动的方向;基于奖励的学习模块提供一种生物启发的学习方法,以适应延迟和稀疏的奖励。为了便于实际应用,整个 SNN 被量化并部署在真正的忆阻硬件平台上,在前向计算阶段与典型的数字加速系统相比,能耗降低了约 21 倍。这项工作为低功耗场景下的机器人导航应用提供了神经形态解决方案的实现思路。
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引用次数: 0
GAPses: Versatile smart glasses for comfortable and fully-dry acquisition and parallel ultra-low-power processing of EEG and EOG. GAPses:多功能智能眼镜,用于舒适的全干式采集和并行超低功耗处理脑电图和眼电图。
Pub Date : 2024-10-10 DOI: 10.1109/TBCAS.2024.3478798
Sebastian Frey, Mattia Alberto Lucchini, Victor Kartsch, Thorir Mar Ingolfsson, Andrea Helga Bernardi, Michael Segessenmann, Jakub Osieleniec, Simone Benatti, Luca Benini, Andrea Cossettini

Recent advancements in head-mounted wearable technology are revolutionizing the field of biopotential measurement, but the integration of these technologies into practical, user-friendly devices remains challenging due to issues with design intrusiveness, comfort, reliability, and data privacy. To address these challenges, this paper presents GAPSES, a novel smart glasses platform designed for unobtrusive, comfortable, and secure acquisition and processing of electroencephalography (EEG) and electrooculography (EOG) signals.We introduce a direct electrode-electronics interface within a sleek frame design, with custom fully dry soft electrodes to enhance comfort for long wear. The fully assembled glasses, including electronics, weigh 40 g and have a compact size of 160 mm × 145 mm. An integrated parallel ultra-low-power RISC-V processor (GAP9, Greenwaves Technologies) processes data at the edge, thereby eliminating the need for continuous data streaming through a wireless link, enhancing privacy, and increasing system reliability in adverse channel conditions. We demonstrate the broad applicability of the designed prototype through validation in a number of EEG-based interaction tasks, including alpha waves, steady-state visual evoked potential analysis, and motor movement classification. Furthermore, we demonstrate an EEG-based biometric subject recognition task, where we reach a sensitivity and specificity of 98.87% and 99.86% respectively, with only 8 EEG channels and an energy consumption per inference on the edge as low as 121 μJ. Moreover, in an EOG-based eye movement classification task, we reach an accuracy of 96.68% on 11 classes, resulting in an information transfer rate of 94.78 bit/min, which can be further increased to 161.43 bit/min by reducing the accuracy to 81.43%. The deployed implementation has an energy consumption of 40 μJ per inference and a total system power of only 12.4 mW, of which only 1.61% is used for classification, allowing for continuous operation of more than 22 h with a small 75 mAh battery.

头戴式可穿戴技术的最新进展正在彻底改变生物电位测量领域,但由于设计的侵入性、舒适性、可靠性和数据隐私等问题,将这些技术集成到实用、用户友好的设备中仍具有挑战性。为了应对这些挑战,本文介绍了一种新型智能眼镜平台 GAPSES,该平台专为无干扰、舒适、安全地采集和处理脑电图(EEG)和脑电图(EOG)信号而设计。完全组装好的眼镜(包括电子设备)重 40 克,体积小巧,仅为 160 毫米 × 145 毫米。集成的并行超低功耗 RISC-V 处理器(GAP9,Greenwaves Technologies 公司)在边缘处理数据,因此无需通过无线链路持续传输数据,增强了私密性,并提高了系统在不利信道条件下的可靠性。我们通过对一些基于脑电图的交互任务(包括阿尔法波、稳态视觉诱发电位分析和运动分类)进行验证,证明了所设计原型的广泛适用性。此外,我们还演示了基于脑电图的生物特征识别任务,在该任务中,我们仅用 8 个脑电图通道就达到了 98.87% 和 99.86% 的灵敏度和特异度,每次边缘推理的能耗低至 121 μJ。此外,在基于 EOG 的眼球运动分类任务中,我们对 11 个类别的准确率达到 96.68%,信息传输速率为 94.78 比特/分钟,通过将准确率降低到 81.43%,信息传输速率可进一步提高到 161.43 比特/分钟。所部署的实现方案每次推理的能耗为 40 μJ,系统总功耗仅为 12.4 mW,其中只有 1.61% 用于分类,使用 75 mAh 的小电池即可连续工作 22 小时以上。
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引用次数: 0
78.8 pJ/b, 100 Mb/s Noncoherent IR-UWB Receiver for Multichannel Neurorecording Implants. 用于多通道神经记录植入体的 78.8 pJ/b、100 Mb/s 非相干 IR-UWB 接收器。
Pub Date : 2024-10-02 DOI: 10.1109/TBCAS.2024.3471818
Razieh Eskandari, Mohamad Sawan

In this article, we present a novel approach for designing a low-power, low-area impulse radio ultra-wideband (IR-UWB) noncoherent receiver capable of achieving a data rate of 100 Mbps. Our proposed receiver demonstrates the ability to demodulate ON-OFF keying pulse streams across the entire lower frequency band defined by the Federal Communication Commission for UWB applications. The key components of the proposed receiver include a reconfigurable differential two-stage low-noise amplifier, a fully differential squarer, narrow-band interface rejection filters, and variable gain baseband amplifiers. These circuits work cohesively to ensure efficient signal reception and processing. To validate the performance of the proposed receiver, we implemented the design using TSMC 40-nm CMOS process technology. A short-range communication including a 1.5 cm tissue layer is tested utilizing a typical upconversion UWB transmitter fabricated in the same technology. Remarkably, the proposed receiver achieves a data rate of 100 Mbps with an impressively low energy efficiency of 78.8 pJ/b and occupies an area of 0.705 mm2. The compact size, remarkable energy efficiency, and high data rate capabilities of the proposed receiver meet the stringent requirements of neural recording implants.

本文介绍了一种设计低功耗、低面积脉冲无线电超宽带(IR-UWB)非相干接收器的新方法,该接收器能够实现 100 Mbps 的数据传输速率。我们提出的接收器展示了在联邦通信委员会为 UWB 应用定义的整个低频段解调 ON-OFF 键控脉冲流的能力。拟议接收器的关键部件包括一个可重新配置的差分两级低噪声放大器、一个全差分平方器、窄带接口抑制滤波器和可变增益基带放大器。这些电路协同工作,确保高效的信号接收和处理。为了验证拟议接收器的性能,我们采用台积电 40 纳米 CMOS 工艺技术实现了设计。利用采用相同技术制造的典型上变频 UWB 发射器,对包括 1.5 厘米组织层在内的短程通信进行了测试。值得注意的是,所提出的接收器实现了 100 Mbps 的数据传输速率,能效低至 78.8 pJ/b,占地面积仅为 0.705 mm2。该接收器体积小、能效高、数据传输率高,符合神经记录植入物的严格要求。
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引用次数: 0
EPOC: A 28-nm 5.3 pJ/SOP Event-driven Parallel Neuromorphic Hardware with Neuromodulation-based Online Learning. EPOC:基于神经调制在线学习的 28 纳米 5.3 pJ/SOP 事件驱动并行神经形态硬件。
Pub Date : 2024-10-02 DOI: 10.1109/TBCAS.2024.3470520
Faquan Chen, Qingyang Tian, Lisheng Xie, Yifan Zhou, Ziren Wu, Liangshun Wu, Rendong Ying, Fei Wen, Peilin Liu

Bio-inspired neuromorphic hardware with learning ability is highly promising to achieve human-like intelligence, particularly in terms of high energy efficiency and strong environmental adaptability. Though many customized prototypes have demonstrated learning ability, learning on neuromorphic hardware still lacks a bio-plausible and unified learning framework, and inherent spike-based sparsity and parallelism have not been fully exploited, which fundamentally limits their computational efficiency and scale. Therefore, we develop a unified, event-driven, and massively parallel multi-core neuromorphic online learning processor, namely EPOC. We present a neuromodulation-based neuromorphic online learning framework to unify various learning algorithms, and EPOC supports high-accuracy local/global supervised Spike Neural Network (SNN) learning with a low-memory-demand streaming single-sample learning strategy through different neuromodulator formulations. EPOC leverages a novel event-driven computation method that fully exploits spike-based sparsity throughout the forward-backward learning phases, and parallel multi-channel and multi-core computing architecture, bringing 9.9× time efficiency improvement compared with the baseline architecture. We synthesize EPOC in a 28-nm CMOS process and perform extensive benchmarking. EPOC achieves state-of-the-art learning accuracy of 99.2%, 98.2%, and 94.3% on the MNIST, NMNIST, and DVS-Gesture benchmarks, respectively. Local-learning EPOC achieves 2.9× time efficiency improvement compared with the global learning counterpart. EPOC operates at a typical clock frequency of 100 MHz, providing a peak 328 GOPS/51 GSOPS throughput and a 5.3 pJ/SOP energy efficiency.

具有学习能力的生物启发神经形态硬件很有希望实现类人智能,特别是在高能效和强环境适应性方面。虽然许多定制的原型已经展示了学习能力,但神经形态硬件的学习仍然缺乏一个生物可信的统一学习框架,基于尖峰的固有稀疏性和并行性也没有得到充分利用,这从根本上限制了其计算效率和规模。因此,我们开发了一种统一、事件驱动和大规模并行的多核神经形态在线学习处理器,即 EPOC。我们提出了一个基于神经调制的神经形态在线学习框架来统一各种学习算法,EPOC通过不同的神经调制器形式,以低内存需求的流式单样本学习策略支持高精度的局部/全局监督穗状神经网络(SNN)学习。EPOC 采用新颖的事件驱动计算方法,在整个前向-后向学习阶段充分利用基于尖峰的稀疏性,并采用并行多通道和多核计算架构,与基线架构相比,时间效率提高了 9.9 倍。我们在 28 纳米 CMOS 工艺中合成了 EPOC,并进行了广泛的基准测试。在 MNIST、NMNIST 和 DVS-Gesture 基准测试中,EPOC 的学习准确率分别达到了 99.2%、98.2% 和 94.3% 的一流水平。与全局学习相比,本地学习 EPOC 的时间效率提高了 2.9 倍。EPOC 的典型时钟频率为 100 MHz,峰值吞吐量为 328 GOPS/51 GSOPS,能效为 5.3 pJ/SOP。
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引用次数: 0
IEEE Transactions on Biomedical Circuits and Systems Publication Information IEEE 生物医学电路与系统论文集》出版信息
Pub Date : 2024-09-26 DOI: 10.1109/TBCAS.2024.3463213
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引用次数: 0
TechRxiv: Share Your Preprint Research with the World! TechRxiv:与世界分享您的预印本研究成果!
Pub Date : 2024-09-26 DOI: 10.1109/TBCAS.2024.3464773
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引用次数: 0
Together, We are advance technology 我们共同推动技术进步
Pub Date : 2024-09-26 DOI: 10.1109/TBCAS.2024.3464777
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引用次数: 0
IEEE Circuits and Systems Society Information 电气和电子工程师学会电路与系统协会信息
Pub Date : 2024-09-26 DOI: 10.1109/TBCAS.2024.3464769
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引用次数: 0
期刊
IEEE transactions on biomedical circuits and systems
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