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Biochar-bacteria coupling system enhanced the bioremediation of phenol wastewater-based on life cycle assessment and environmental safety analysis. 基于生命周期评估和环境安全分析的生物炭-细菌耦合系统增强了苯酚废水的生物修复能力。
Pub Date : 2024-11-05 DOI: 10.1016/j.jhazmat.2024.136414
Xuejiao An, Yanlin Wang, Chenglong Yu, Xiaojing Hu

The efficient treatment of phenol wastewater is of great necessity since it induces serious pollution of water and soil ecosystems. Using biochar-immobilized functional microorganisms can innovatively and sustainably deal with the existing problem. In this study, we utilized response surface methodology (RSM) combined with life cycle assessment (LCA) to improve phenol biodegradation rate through a novel separated alkali-resistant and thermophilic strain Bacillus halotolerans ACY. Bioinformatic analysis revealed the genetic foundation of ACY to adapt to harsh environments. The characteristics of pig manure biochar (PMB) produced at varying pyrolysis temperatures (300-700 ℃) and adsorption experiment were investigated, immobilization of the phenol-degrading ACY on PMB600 under alkaline and high pollution load promoted phenol removal and extreme environment resistance, and the phenol removal rate reached 99.5 % in 7d in actual phenol wastewater, which increased compared with those achieved by PMB (50.6 %) and free bacteria (80.5 %) alone. Scanning Electron Microscope (SEM) and Fourier transform infrared spectrometry (FTIR) observations indicated the successful bacterial immobilization on PMB600. Reusability and economic cost study further demonstrated PMB600 as an excellent carrier for wastewater treatment. LC-MS, toxicology and carbon footprint analyses demonstrated that bacterial metabolism exerted synergy with adsorption for phenol removal, while biodegradation exerted the predominant impact on the immobilized bacterial system. This study provides an eco-friendly and effective approach to treat phenol wastewater.

酚类废水会对水和土壤生态系统造成严重污染,因此必须对其进行有效处理。使用生物炭固定化功能微生物可以创新性地、可持续地解决现有问题。在本研究中,我们利用响应面方法(RSM)结合生命周期评估(LCA),通过分离出的新型耐碱嗜热菌株卤代不耐热芽孢杆菌(Bacillus halotolerans ACY)来提高苯酚的生物降解率。生物信息学分析揭示了 ACY 适应恶劣环境的遗传基础。研究了不同热解温度(300-700 ℃)下产生的猪粪生物炭(PMB)的特性,并进行了吸附实验。在碱性和高污染负荷下,将降解苯酚的 ACY 固定在 PMB600 上,促进了苯酚的去除和对极端环境的耐受性,在实际苯酚废水中 7d 苯酚去除率达到 99.5%,与单独使用 PMB(50.6%)和游离菌(80.5%)相比有所提高。扫描电子显微镜(SEM)和傅立叶变换红外光谱仪(FTIR)的观察结果表明,细菌在 PMB600 上的固定化取得了成功。可重复使用性和经济成本研究进一步证明 PMB600 是一种用于废水处理的优良载体。LC-MS、毒理学和碳足迹分析表明,细菌代谢与吸附对苯酚的去除具有协同作用,而生物降解则对固定化细菌系统产生了主要影响。这项研究为处理苯酚废水提供了一种环保而有效的方法。
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引用次数: 0
Antibiotic intermediates and antibiotics synergistically promote the development of multiple antibiotic resistance in antibiotic production wastewater. 抗生素中间体和抗生素会协同促进抗生素生产废水中多种抗生素耐药性的产生。
Pub Date : 2024-11-05 Epub Date: 2024-08-22 DOI: 10.1016/j.jhazmat.2024.135601
Sun Miao, Yanyan Zhang, Baochan Li, Xin Yuan, Cong Men, Jiane Zuo

Antibiotic resistance (AR) is a major public health concern. Antibiotic intermediates (AIs) used in the production of semisynthetic antibiotics have the same bioactive structure as parent antibiotics and synthetic antibiotic production wastewater usually contains high concentrations of residual AIs; however, the effects of AIs and their interactive effects with antibiotics on the emergence of AR are unknown. In this study, antibiotic-sensitive E. coli K12 was exposed to five types of β-lactam AIs and their parent antibiotic ampicillin to analyze their impact on the evolution of multiple AR. The results indicated that AI 6-APA inhibits bacterial growth and stimulates the production of reactive oxygen species, as well as induces AR and antibiotic persistence like the parent antibiotic AMP. Combined exposure to 6-APA and AMP synergistically stimulated the induction of multiple AR and antibiotic persistence. The resistance mutation frequency increased up to 6.1 × 106-fold under combined exposure and the combination index reached 1326.5, indicating a strong synergy of 6-APA and AMP. Phenotypic and genotypic analyses revealed that these effects were associated with the overproduction of reactive oxygen species, enhanced stress response signatures, and activation of efflux pumps. These findings provide evidence and mechanistic insights into AR induction by AIs in antibiotic production wastewater.

抗生素耐药性(AR)是一个重大的公共卫生问题。用于生产半合成抗生素的抗生素中间体(AIs)具有与母体抗生素相同的生物活性结构,合成抗生素生产废水中通常含有高浓度的残留 AIs;然而,AIs 及其与抗生素的相互作用对 AR 的产生的影响尚不清楚。本研究将对抗生素敏感的大肠杆菌K12暴露于五种β-内酰胺类人工合成物及其母体抗生素氨苄西林中,分析它们对多种AR进化的影响。结果表明,6-APA AI 能抑制细菌生长,刺激活性氧的产生,并能像母体抗生素 AMP 一样诱导 AR 和抗生素持久性。同时接触 6-APA 和 AMP 会协同刺激多种 AR 的诱导和抗生素的持久性。在联合暴露的情况下,耐药性突变频率增加到 6.1 × 106 倍,联合指数达到 1326.5,表明 6-APA 和 AMP 有很强的协同作用。表型和基因型分析表明,这些效应与活性氧的过度产生、应激反应特征的增强以及外排泵的激活有关。这些发现提供了抗生素生产废水中人工合成物诱导 AR 的证据和机理。
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引用次数: 0
Revealing the essence of anion ligands in regulating amorphous MnOx to activate peracetic acid for micropollutant removal. 揭示阴离子配体在调节无定形氧化锰活化过乙酸以去除微污染物方面的本质。
Pub Date : 2024-10-31 DOI: 10.1016/j.jhazmat.2024.136361
Yudan Dong, Si Sun, Yunzhe Zheng, Jiamei Liu, Peng Zhou, Zhaokun Xiong, Jing Zhang, Zhi-Cheng Pan, Chuan-Shu He, Bo Lai

How the anion ligands of manganese precursors affect the catalytic activity of amorphous manganese oxides (MnOx) in Fenton-like process is poorly understood. Here, five amorphous MnOx synthesized by Mn(II) precursors with different ligands were characterized and adopted to activate peracetic acid (PAA) for bisphenol A (BPA) degradation. Although > 90 % BPA removal was achieved in the five MnOx/PAA processes via both adsorption and oxidation, the oxidation kobs greatly differentiates by the ligands types with the order of MnOx-N > MnOx-S > MnOx-Cl > MnOx-AA > MnOx-OA. Ligands types would affect the specific surface area of MnOx and their ability to adsorb BPA, however which is not the decisive factor in determining the contaminant oxidation efficiency. Multiple experimental results indicate that the generation of oxygen vacancies induced by the ligands alters the Mn(III)/Mn(IV) ratio, ultimately contributing to the different efficiency of BPA oxidation driven by the direct electron transfer mechanism. Moreover, amorphous MnOx holds the promise of practical applications in catalytic PAA of various micropollutants with good stability. This study advances the fundamental understanding of ligand-regulated amorphous MnOx-catalyzed PAA process.

人们对锰前体的阴离子配体如何影响无定形锰氧化物(MnOx)在类似芬顿过程中的催化活性知之甚少。在此,研究人员对由含不同配体的锰(II)前体合成的五种无定形氧化锰进行了表征,并将其用于活化过乙酸(PAA)以降解双酚 A(BPA)。尽管在五种 MnOx/PAA 工艺中,通过吸附和氧化两种方式,双酚 A 的去除率均大于 90%,但氧化作用因配体类型的不同而有很大差异,顺序为 MnOx-N > MnOx-S > MnOx-Cl > MnOx-AA > MnOx-OA。配体类型会影响氧化锰的比表面积及其吸附双酚 A 的能力,但这并不是决定污染物氧化效率的决定性因素。多项实验结果表明,配体诱导产生的氧空位会改变锰(III)/锰(IV)的比例,最终导致直接电子转移机制驱动的双酚 A 氧化效率不同。此外,无定形氧化锰具有良好的稳定性,有望实际应用于各种微污染物的催化 PAA。本研究加深了人们对配体调控非晶态氧化锰催化 PAA 过程的基本认识。
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引用次数: 0
Unique role of Mn(II) in enhancing electro-oxidation of organic pollutants on anodes with low oxygen evolution potential at low current density. 锰(II)在低电流密度、低氧进化电位的阳极上增强有机污染物电氧化作用的独特作用。
Pub Date : 2024-10-31 DOI: 10.1016/j.jhazmat.2024.136332
Erdan Hu, Yuhua Ye, Bing Wang, Hefa Cheng

This study systematically explored the role of Mn(II) in the removal of 4-chlorophenol (4-CP) by electro-oxidation (EO) employing anodes with low oxygen evolution potential (OEP), i.e., Ti/RuO2-IrO2, Ti/Pt, and Ti/Ti4O7, as well as anodes with high OEP, namely, Ti/PbO2, Ti/SnO2, and boron-doped diamond (Si/BDD). Mn(II) significantly promoted 4-CP removal on the anodes with low OEP at fairly low current density (0.04 to 1 mA/cm2), but had minimal to negative impact on those with high OEP. Cyclic voltammetry and X-ray photoelectron spectra revealed that Mn(II) was oxidized to Mn(III), then to Mn(IV) on the anodes with low OEP, whereas its was oxidized directly to Mn(IV) on those with high OEP. Deposition of manganese oxide on the anodes with low OEP suppressed oxygen evolution reaction (OER) in EO process, but enhanced OER on those with high OEP. Quenching and spectral results consistently indicated that Mn(III) and Mn(IV) were the primary species responsible for enhancing 4-CP removal on the anodes with low OEP. These findings provide mechanistic insights into the redox transformation of Mn(II) in EO and the theoretical basis for a novel strategy to boost pollutant degradation in EO systems using low OEP anodes through coupling with the redox chemistry of manganese.

本研究系统地探讨了 Mn(II)在利用低氧进化电位(OEP)阳极(即 Ti/RuO2-IrO2、Ti/Pt 和 Ti/Ti4O7)以及高 OEP 阳极(即 Ti/PbO2、Ti/SnO2 和掺硼金刚石(Si/BDD))通过电氧化(EO)去除 4-氯苯酚(4-CP)过程中的作用。在相当低的电流密度下(0.04 至 1 mA/cm2),锰(II)能明显促进低 OEP 阳极对 4-CP 的去除,但对高 OEP 阳极的影响很小,甚至是负面的。循环伏安法和 X 射线光电子能谱显示,在 OEP 值低的阳极上,锰(II)被氧化成锰(III),然后再氧化成锰(IV),而在 OEP 值高的阳极上,锰(II)直接被氧化成锰(IV)。在 OEP 值低的阳极上沉积氧化锰抑制了 EO 过程中的氧进化反应(OER),但在 OEP 值高的阳极上却增强了 OER。淬火和光谱结果一致表明,锰(III)和锰(IV)是在低 OEP 阳极上提高 4-CP 去除率的主要物质。这些发现从机理上揭示了氧化锰(II)在环氧乙烷中的氧化还原转化,并为通过与锰的氧化还原化学耦合,在使用低 OEP 阳极的环氧乙烷系统中促进污染物降解的新策略提供了理论基础。
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引用次数: 0
Catalytic membrane with dual-layer structure for ultrafast degradation of emerging contaminants in surface water treatment. 用于超快降解地表水处理中新出现污染物的双层结构催化膜。
Pub Date : 2024-10-31 DOI: 10.1016/j.jhazmat.2024.136333
Qieyuan Gao, Xinyao Jin, Xi Zhang, Junwei Li, Peng Liu, Peijie Li, Xinsheng Luo, Weijia Gong, Daliang Xu, Raf Dewil, Heng Liang, Bart Van der Bruggen

The catalytic membrane-based oxidation-filtration process integrates physical separation and chemical oxidation, offering a highly efficient water purification strategy. However, the oxidation-filtration process is limited in practical applications due to the short residence time of milliseconds within the catalytic layer and the interference of coexisting organic pollutants in real water. Herein, a dual-layer membrane containing a top selective layer and a bottom catalytic layer was fabricated using an in situ co-casting method with a double-blade knife. Experimental results demonstrated that the selective layer rejected macromolecular organic pollutants, thereby alleviating their interference with bisphenol A (BPA) degradation. Concurrently, the catalytic layer activated peracetic acid oxidant and achieved a high BPA degradation exceeding 90 % in milliseconds with reactive oxygen species (especially •OH). The finite-element analysis confirmed a high-concentration reaction field occupying the pore cavity of the catalytic layer, enhancing collision probability between reactive oxygen species and BPA, i.e., the nano-confinement effect. Additionally, the dual-layer membrane achieved a long-term stable performance for emerging contaminant degradation in surface water treatment. This work underscores a novel catalytic membrane structure design for high-performance oxidation-filtration processes and elucidates its mechanisms underlying ultrafast degradation.

基于催化膜的氧化-过滤过程集物理分离和化学氧化于一体,是一种高效的水净化策略。然而,由于催化层内的停留时间短至几毫秒,加上实际水中共存的有机污染物的干扰,氧化-过滤过程在实际应用中受到限制。在此,我们采用双刃刀原位共铸法制造了一种包含顶部选择层和底部催化层的双层膜。实验结果表明,选择层可阻挡大分子有机污染物,从而减轻其对双酚 A(BPA)降解的干扰。同时,催化层激活了过乙酸氧化剂,并在几毫秒内利用活性氧(尤其是-OH)实现了超过 90% 的双酚 A 降解。有限元分析证实,高浓度反应场占据了催化层的孔腔,提高了活性氧与双酚 A 之间的碰撞概率,即纳米聚集效应。此外,双层膜在地表水处理中实现了长期稳定的新污染物降解性能。这项研究强调了用于高性能氧化-过滤过程的新型催化膜结构设计,并阐明了其超快降解的机理。
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引用次数: 0
Phototransformation and photoreactivity of MPs-DOM in aqueous environment: Key role of MPs structure decoded by optical and molecular signatures. MPs-DOM 在水环境中的光转化和光活性:通过光学和分子特征解读 MPs 结构的关键作用。
Pub Date : 2024-10-31 DOI: 10.1016/j.jhazmat.2024.136331
Saisai Guo, Linan Liu, Lan Wang, Jingchun Tang

The dissolved organic matter (DOM) derived from microplastics (MPs-DOM) can be one of the photoactive components in DOM. However, information on the properties and photoreactivity of MPs-DOM during phototransformation is limited. Here, we investigated the properties and photoreactivity of MPs-DOM from polyolefins (MPs-DOM-POs), MPs-DOM derived from benzene-containing polymers (MPs-DOM-BCPs), and Suwannee River natural organic matter (SR-NOM), during a 168-hour phototransformation. After phototransformation, all examined types of DOM exhibit a decrease in concentration and molecular weight. Notably, MPs-DOM-POs display increased aromaticity and saturation, while MPs-DOM-BCPs and SR-NOM show reduced aromaticity and saturation. MPs-DOM-POs present higher steady-state concentrations of •OH but much lower steady-state concentrations of 1O2 than those of MPs-DOM-BCPs. In comparison, MPs-DOM produce more •OH but less 1O2 than SR-NOM. This study proposes that the diversification of aliphatic C─H bonds (arylation and carbonylation) by reactive intermediates (especially •OH) is the main pathway for MPs-DOM-POs phototransformation for the first time. On the other hand, the cleavage on the aromatic carboxylic acids by reactive intermediates (especially 1O2) is the main mechanism for MPs-DOM-BCPs and SR-NOM phototransformation. Our findings provide new insights into the phototransformation and photoreactivity of MPs-DOM and help to understand the potential risks of MPs in aqueous environment.

来自微塑料的溶解有机物(DOM)(MPs-DOM)可能是 DOM 中具有光活性的成分之一。然而,有关 MPs-DOM 在光转化过程中的性质和光活性的信息非常有限。在此,我们研究了来自聚烯烃的 MPs-DOM(MPs-DOM-POs)、来自含苯聚合物的 MPs-DOM(MPs-DOM-BCPs)和苏瓦尼河天然有机物(SR-NOM)在 168 小时光转化过程中的性质和光活性。光转化后,所有受检类型的 DOM 的浓度和分子量都有所下降。值得注意的是,MPs-DOM-POs 的芳香度和饱和度都有所提高,而 MPs-DOM-BCPs 和 SR-NOM 的芳香度和饱和度都有所降低。与 MPs-DOM-BCPs 相比,MPs-DOM-POs 的 -OH 稳态浓度更高,但 1O2 稳态浓度却低得多。相比之下,与 SR-NOM 相比,MPs-DOM 产生的 -OH 更多,但 1O2 更少。本研究首次提出,反应性中间产物(尤其是 -OH)使脂肪族 C─H 键多样化(芳基化和羰基化)是 MPs-DOM-POs 光转化的主要途径。另一方面,反应性中间产物(尤其是 1O2)对芳香族羧酸的裂解是 MPs-DOM-BCPs 和 SR-NOM 光转化的主要机制。我们的研究结果为了解 MPs-DOM 的光转化和光活性提供了新的视角,有助于理解 MPs 在水环境中的潜在风险。
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引用次数: 0
pH dependence of reactive oxygen species generation and pollutant degradation in Fe(II)/O2/tripolyphosphate system. Fe(II)/O2/tripolyphosphate 系统中活性氧生成和污染物降解的 pH 值依赖性。
Pub Date : 2024-10-16 DOI: 10.1016/j.jhazmat.2024.136174
Chengwu Zhang, Anqi Yang, Bing Qin, Wei Zhao, Chuipeng Kong, Chuanyu Qin

It has been reported that tripolyphosphate (TPP) can effectively enhance the activation of O2 by Fe(II) to remove organic pollutants in the environment. However, the influence of solution pH on the generation and conversion of reactive oxygen species (ROS) and their degradation of pollutants in the Fe(II)/O2/TPP system needs further investigation. In this study, we demonstrated that O2•- and •OH were the main ROS responsible for degradation in the system at different pH conditions, and their formation rates were calculated using a steady-state model. Experiments combined with density functional theory (DFT) calculations showed that the p-nitrophenol (PNP) degradation pathway in the Fe(II)/O2/TPP system is regulated by solution pH. Specifically, at pH = 3, the existence of Fe(II) in the solution is dominated by [Fe(II)(HTPP)2]2-, which leads to a rapid conversion from O2 and HO2• to generate •OH, and PNP is primarily oxidatively degraded. However, at pH = 5/7, [Fe(II)(TPP)2]4- is taking the lead with which O2•- is accumulated in the solution due to the slow conversion to •OH in this condition, and the PNP is mainly reductively degraded. This study proposes a new strategy to achieve the targeted oxidative/reductive removal of different types of pollutants by simply varying the solution pH in the Fe(II)/O2/TPP system.

据报道,三聚磷酸钠(TPP)能有效增强铁(II)对氧气的活化作用,从而去除环境中的有机污染物。然而,在 Fe(II)/O2/TPP 系统中,溶液 pH 值对活性氧(ROS)的生成和转化及其对污染物降解的影响还需要进一步研究。在本研究中,我们证明了在不同的 pH 值条件下,O2-- 和 -OH 是该体系中导致降解的主要 ROS,并利用稳态模型计算了它们的形成率。实验结合密度泛函理论(DFT)计算表明,Fe(II)/O2/TPP体系中对硝基苯酚(PNP)的降解途径受溶液pH值的调节。具体来说,在 pH = 3 时,溶液中的 Fe(II) 以 [Fe(II)(HTPP)2]2- 为主,导致 O2 和 HO2- 快速转化生成 -OH,PNP 主要被氧化降解。然而,在 pH = 5/7 时,[Fe(II)(TPP)2]4- 起主导作用,由于在此条件下转化为 -OH 的速度较慢,溶液中积累了 O2-,PNP 主要被还原降解。本研究提出了一种新策略,只需改变 Fe(II)/O2/TPP 体系中溶液的 pH 值,就能有针对性地氧化/还原去除不同类型的污染物。
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引用次数: 0
Hot spots of resistance: Transit centers as breeding grounds for airborne ARG-carrying bacteriophages. 抗药性的热点:转运中心是空气中携带 ARG 的噬菌体的滋生地。
Pub Date : 2024-10-16 DOI: 10.1016/j.jhazmat.2024.136165
Jing Zhang, Jiayu Shang, Beibei Liu, Dong Zhu, Qinfen Li, Li Yin, Okugbe Ebiotubo Ohore, Shaobai Wen, Changfeng Ding, Yican Zhang, Zhengfu Yue, Yukun Zou

The presence of pathogenic bacteria and antibiotic resistance genes (ARGs) in urban air poses a significant threat to public health. While prevailing research predominantly focuses on the airborne transmission of ARGs by bacteria, the potential influence of other vectors, such as bacteriophages, is often overlooked. This study aims to investigate the characteristics of phages and ARGs in aerosols originating from hospitals, public transit centers, wastewater treatment plants, and landfill sites. The average abundance of ARGs carried by phages in the public transit centers was 8.81 ppm, which was 2 to 3 times higher than that at the other three sites. Additionally, the abundance of ARGs across different risk levels at this site was also significantly higher than at the other three sites. The assembled phage communities bearing ARGs in public transit centers are chiefly governed by homogeneous selection processes, likely influenced by human movement. Furthermore, observations at public transit sites revealed that the average abundance ratio of virulent phages to their hosts was 1.01, and the correlation coefficient between their auxiliary metabolic genes and hosts' metabolic genes was 0.59, which were 20 times and 3 times higher, respectively, than those of temperate phages. This suggests that virulent phages may enhance their survival by altering host metabolism, thereby aiding the dispersion of ARGs and bacterial resistance. These revelations furnish fresh insights into phage-mediated ARG transmission, offering scientific substantiation for strategies aimed at preventing and controlling resistance within aerosols.

城市空气中存在的致病细菌和抗生素耐药基因(ARGs)对公众健康构成了严重威胁。目前的研究主要集中在细菌通过空气传播 ARGs 的问题上,而噬菌体等其他载体的潜在影响往往被忽视。本研究旨在调查来自医院、公共交通中心、污水处理厂和垃圾填埋场的气溶胶中噬菌体和 ARGs 的特征。在公共交通中心,噬菌体携带的 ARGs 平均含量为 8.81 ppm,是其他三个地点的 2 到 3 倍。此外,该地点不同风险等级的 ARGs 丰度也明显高于其他三个地点。在公共交通中心,带有 ARGs 的噬菌体群落主要受同质选择过程的支配,很可能受到人类活动的影响。此外,在公交站点的观察发现,毒力噬菌体与宿主的平均丰度比为1.01,其辅助代谢基因与宿主代谢基因的相关系数为0.59,分别是温带噬菌体的20倍和3倍。这表明,毒性噬菌体可能通过改变宿主的新陈代谢来提高自身的生存能力,从而有助于ARGs的扩散和细菌的抗药性。这些发现为噬菌体介导的 ARG 传播提供了新的视角,为气溶胶中抗药性的预防和控制策略提供了科学依据。
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引用次数: 0
Antibiotic resistance at environmental multi-media interfaces through integrated genotype and phenotype analysis. 通过基因型和表型综合分析研究环境多媒体界面的抗生素耐药性。
Pub Date : 2024-10-15 DOI: 10.1016/j.jhazmat.2024.136160
Chen-Xi Fu, Chen Chen, Qian Xiang, Yi-Fei Wang, Lu Wang, Feng-Yuan Qi, Dong Zhu, Hong-Zhe Li, Li Cui, Wei-Li Hong, Matthias C Rillig, Yong-Guan Zhu, Min Qiao

Antibiotic resistance is currently an unfolding global crisis threatening human health worldwide. While antibiotic resistance genes (ARGs) are known to be pervasive in environmental media, the occurrence of antibiotic resistance at interfaces between two or more adjacent media is largely unknown. Here, we designed a microcosm study to simulate plastic pollution in paddy soil and used a novel method, stimulated Raman scattering coupled with deuterium oxide (D2O) labelling, to compare the antibiotic resistance in a single medium with that at the interface of multiple environmental media (plastic, soil, water). Results revealed that the involvement of more types of environmental media at interfaces led to a higher proportion of active resistant bacteria. Genotypic analysis showed that ARGs (especially high-risk ARGs) and mobile genetic elements (MGEs) were all highly enriched at the interfaces. This enrichment was further enhanced by the co-stress of heavy metal (arsenic) and antibiotic (ciprofloxacin). Our study is the first to apply stimulated Raman scattering to elucidate antibiotic resistance at environmental interfaces and reveals novel pathway of antibiotic resistance dissemination in the environment and overlooked risks to human health.

目前,抗生素耐药性正在成为威胁全球人类健康的全球性危机。众所周知,抗生素耐药性基因(ARGs)普遍存在于环境介质中,但抗生素耐药性在两种或多种相邻介质界面上的发生情况却大多不为人知。在此,我们设计了一个模拟稻田土壤中塑料污染的微观世界研究,并使用一种新方法--刺激拉曼散射与氧化氘(D2O)标记相结合--来比较单一介质中的抗生素耐药性与多种环境介质(塑料、土壤、水)界面上的抗生素耐药性。结果表明,界面上的环境介质种类越多,活性耐药菌的比例就越高。基因型分析表明,ARGs(尤其是高风险 ARGs)和移动基因元件(MGEs)在界面处都高度富集。重金属(砷)和抗生素(环丙沙星)的共同作用进一步增强了这种富集。我们的研究首次应用受激拉曼散射来阐明环境界面上的抗生素耐药性,揭示了抗生素耐药性在环境中传播的新途径,以及对人类健康的潜在风险。
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引用次数: 0
Polystyrene nanoplastics enhance thrombosis through adsorption of plasma proteins. 聚苯乙烯纳米塑料通过吸附血浆蛋白促进血栓形成。
Pub Date : 2024-10-15 DOI: 10.1016/j.jhazmat.2024.136168
Chao Sheng, Guozhen Wang, Zijia Liu, Yuchen Zheng, Zijie Zhao, Duo Tang, Wenzhuo Li, Ao Li, Qi Zong, Renhang Zhou, Xiaonan Hou, Mengfei Yao, Zhixiang Zhou

Plastic products offer remarkable convenience for modern life. However, growing concerns are emerging regarding the potential health hazards posed by nanoplastics, which formed as plastics break down. Currently, the biological effects and mechanisms induced by nanoplastics are largely underexplored. In this study, we report that polystyrene nanoplastics can enter the bloodstream and enhance thrombus formation. Our findings show that polystyrene nanoplastics adsorb plasma proteins, particularly coagulation factor XII and plasminogen activator inhibitor-1, play a key role in this process, as demonstrated by proteomics, bioinformatic analyses, and molecular dynamics simulations. The adsorption of these proteins by nanoplastics is an essential factor in thrombosis enhancement. This newly uncovered pathway of protein adsorption leading to enhanced thrombosis provides new insights into the biological effects of nanoplastics, which may inform future safety and environmental risk assessment of plastics.

塑料产品为现代生活提供了极大的便利。然而,人们越来越关注塑料分解过程中形成的纳米塑料对健康造成的潜在危害。目前,人们对纳米塑料的生物效应和机理还缺乏深入研究。在本研究中,我们报告了聚苯乙烯纳米塑料可进入血液并促进血栓形成。我们的研究结果表明,聚苯乙烯纳米塑料吸附血浆蛋白,尤其是凝血因子 XII 和纤溶酶原激活剂抑制剂-1,在这一过程中发挥了关键作用,这一点已通过蛋白质组学、生物信息学分析和分子动力学模拟得到证实。纳米塑料对这些蛋白质的吸附是增强血栓形成的一个重要因素。这种新发现的导致血栓形成增强的蛋白质吸附途径为了解纳米塑料的生物效应提供了新的视角,可为未来塑料的安全和环境风险评估提供参考。
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引用次数: 0
期刊
Journal of hazardous materials
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