Journal of pharmacy & bioallied sciences最新文献

Background: Sleep disorders and ocular conditions are prevalent health concerns with significant impact on the quality of life. However, the relationship between them remains underexplored. Additionally, therapeutic interventions targeting both sleep and eye health are explored.

Materials and methods: A prospective clinical study was conducted involving 500 participants aged between 30 and 65 years, recruited from an outpatient clinic specializing in sleep disorders and ophthalmology. Participants underwent comprehensive assessments including polysomnography for sleep disorders diagnosis and ophthalmic examinations for ocular condition evaluation. Sleep quality was assessed using standardized questionnaires, while ocular health was evaluated through clinical examination, including measurements of intraocular pressure, tear film break-up time, and retinal imaging. Statistical analyses were performed using Chi-square tests and logistic regression models to determine associations between sleep disorders and ocular conditions, adjusting for potential confounders.

Results: Among the participants, 35% were diagnosed with sleep apnea, 25% with insomnia, 20% with dry eye syndrome, 15% with glaucoma, and 10% with diabetic retinopathy. Significant associations were found between sleep disorders and ocular conditions. Participants with sleep apnea were more likely to have dry eye syndrome (odds ratio [OR] = 2.5, 95% confidence interval [CI] = 1.8-3.4, P < 0.001) and glaucoma (OR = 1.8, 95% CI = 1.3-2.5, P = 0.002). Similarly, insomnia was associated with dry eye syndrome (OR = 2.2, 95% CI = 1.5-3.1, P < 0.001) and diabetic retinopathy (OR = 1.6, 95% CI = 1.1-2.3, P = 0.012).

Conclusion: This study highlights the significant association between sleep disorders and ocular conditions, suggesting a potential bidirectional relationship.

Background: Virtual surgical planning (VSG), also known as computer-assisted reconstruction, has started to become the norm for more complex patients in many centers in recent times.

Aim: This study was conducted to evaluate the VSG in maxillofacial reconstruction surgery.

Methods and materials: This study included 20 patients who underwent surgery for maxillofacial reconstruction. The study participants were divided into two main categories: Category 1: Conventional surgical planning (CSG). Category 2: VSG. The surgical planning in both categories, including the evaluation of volume of defect, length, width, and height of graft, to be placed.

Results: The gap between defect to be reconstructed and graft placed was greater in CSG as compared to VSG. The distance of graft from actual location was lesser in VSG as compared to CSG. The findings were significant statistically. Frequency of success was 93.21% and 97.47%, respectively. The frequency of success was greater in VSG as compared to CSG.

Conclusion: Virtual surgical planning is more effective in maxillofacial reconstruction surgery.

Background: Ocular manifestations of systemic diseases pose significant challenges to clinicians due to their diverse presentations and potential impact on vision. Understanding these manifestations is crucial for effective patient management and prevention of vision loss.

Materials and methods: In this prospective clinical study, we investigated ocular manifestations in 50 patients with various systemic diseases, including diabetes mellitus, hypertension, autoimmune disorders, and infectious diseases. Patients underwent comprehensive ocular examinations and systemic evaluations to assess the prevalence and characteristics of ocular complications associated with each systemic condition.

Conclusion: Diabetic retinopathy was the most common ocular manifestation among diabetic patients, while hypertensive retinopathy predominated in hypertensive individuals. Autoimmune disorders were associated with uveitis and retinal vasculitis, whereas infectious diseases presented with ocular infections. Correlation analyses revealed significant associations between systemic parameters and ocular findings, emphasizing the importance of systemic disease control in preventing vision-threatening complications.

Introduction: The permanent pacemaker implantation has a history of more than 60 years with improved mortality and quality of life but also recorded many complications.

Objectives: The objective is to evaluate the rate of early complications at the National Heart Institute of Vietnam and the factors associated with the early complication of the permanent pacemaker implantation procedure.

Methods: A cross-sectional descriptive is about 294 patients who received permanent pacemaker implantation at the National Heart Institute of Vietnam from 01/08/2020 to 30/30/2020.

Results: The rate of complications is statistically higher in the diabetic group (OR = 2.5; 95% CI: 1.1-5.6), chronic kidney failure (OR = 2.7; 95% CI: 1.1-6.6), preheart surgery (OR = 3.8; 95% CI: 1.3-11.8), taking oral anticoagulants (OR = 4.3; 95% CI: 1.9-9.9), dual antiplatelets (OR = 2.95; 95% CI: 1.1-8.1), continuation to maintain anticoagulants, or dual antiplatelets (OR = 2.7; 95% CI: 1.2-6.4).

Conclusion: Early onset of complications (onset of early complications) has been associated with some factors such as diabetes disease, chronic kidney failure, preheart surgery, oral anticoagulants, dual antiplatelets, continuation to maintain anticoagulation, and antiplatelets with statistical significance.

Background: Apical periodontitis and irreversible pulpitis are typical dental conditions treated with "Root Canal Treatment (RCT)". Single-visit RCT has become a viable alternative to the multi-visit RCT method used in traditional RCT.

Methods: A total of 100 RCT participants were randomised to either the single-visit or multiple-visit groups at random. A "Visual Analogue Scale (VAS)" was used to measure post-operative discomfort at 24, 48, and 72 hours. At 6 and 12 months, peri-apical radiographs were used to assess the healing results.

Results: At all time periods, there were no discernible variations in post-operative discomfort between the single-visit and multiple-visit groups. In contrast to the multiple-visit group, the single-visit group had greater rates of full healing at both 6 and 12 months.

Conclusion: Compared to multiple-visit RCT, single-visit RCT provides similar post-operative pain alleviation and may result in better healing results. This suggests that single-visit RCT is a feasible and effective management option for patients who need root canal therapy.

Background: Forensic medicine deals with the identification of individuals, but it also involves legal documents, financial transactions, and civil affairs. One of the most established and trustworthy biometric techniques is the fingerprint, which is accepted as valid identification documentation for individuals.

Methods: This cross-sectional research involved 420 Saudi students, including 300 males and 120 females, aged between 18 and 27. On a white A4-sized Performa, rolled imprints of each participant's ten fingers were obtained, and these were categorized into loops, whorls, arches, and composites. The relationship between the ABO and Rh blood groups and fingerprint patterns were compared using the Chi-square test to see for any correlation.

Results: The study included 420 participants in total. Of these 420, there were males 300 (71.4%), and females 112 (28.6%) participants, respectively. Of the 420 participants, blood groups, such as A, B, AB, and O, were represented by 112 (26.7%), 75 (17.8%), 20 (4.8%), and 213 (50.7%) of the participants, respectively. Out of the 4200 fingerprints, 127 (3.0%) were composite, 1547 (36.8%) were whorl, 197 (4.7%) were arch, and 2329 (55.5%) were loop. An analysis of the fingerprint patterns of the ABO blood group revealed a statistically significant variance (P = 0.0002).

Conclusion: According to this study, the most common fingerprints were loop (55.5%) and whorl (36.8%). ABO blood group differences in fingerprint patterns were found to be statistically significant.

Objective: This retrospective review aimed to analyze the outcomes of tonsillectomy and adenoidectomy (T and A) procedures in pediatric patients, focusing on complications and recurrence rates.

Methods: Medical records of pediatric patients who underwent T and A were retrospectively reviewed. Data on patient demographics, preoperative indications, surgical techniques, intraoperative findings, postoperative complications, and recurrence rates were collected and analyzed.

Results: A total of 240 pediatric patients were included in the study. Postoperative complications occurred with postoperative bleeding being the most common (5.2%). Other complications included infection (3.1%), respiratory compromise (1.7%), and velopharyngeal insufficiency (0.6%). Recurrence of tonsillitis and adenoiditis was observed in 6.7% of cases, respectively.

Conclusion: This retrospective review provides valuable insights into the outcomes of T and A procedures in pediatric patients. Postoperative complications, including bleeding and infection, underscore the importance of meticulous surgical technique and postoperative care. Recurrence rates of tonsillitis and adenoiditis highlight the need for long-term follow-up and surveillance in pediatric patients undergoing T and A.

Aim: To assess the co-relation between mandibular flare and thickness of lingual cortex in relation to the third molars.

Materials and methods: Retrospectively obtained computed tomography (CT) data of 26 patients was used after classifying them into respective skeletal malocclusion groups (classes I, II, and III). Thickness of lingual cortex was measured at crestal, middle, and apical levels in mandibular third molar region. Two angular and two linear measurements were used to measure mandibular flare. Angular measurements included the angle between condylion (Co) and menton (Me), and between gonion (Go) and menton (Me). Linear measurements included bigonial and bicondylion widths.

Results: The two angular measurements did not differ significantly among the three skeletal malocclusion groups. Contrastingly, bicondylion width differed significantly among the three groups. Class II group showed no significant correlation between mandibular flare and lingual cortical thickness. Class III group demonstrated a significant negative correlation of linear and angular measurements with cortical bone thickness. Bicondylion width was significantly more in Class III group than in other skeletal groups, which proved an increased mandibular flare in patients with Class III malocclusion.

Conclusion: Increase in mandibular flare was associated with decreased thickness of lingual cortical bone.

Background: Attempts should be made to identify the molecule-based biomarkers, which give indication about the progression of precancer and malignancy of the oral area.

Aim: To evaluate the reliability of methylation of genes of saliva like P16, MGMT, and DAP-K as biomarkers for diagnosis of oral squamous cell carcinoma.

Methods and materials: This study included 30 cases of histopathologically proven cases of oral squamous cell carcinoma. This study was conducted to detect demethylation of genes P16, MGMT, and DAP-K in saliva in these patients. Approximately, 1 mL of saliva was collected from each individual. Bisulfite sequencing PCR (BSP) was done with bisulfite conversion-specific primers produced by MethPrimer. The BSP compounds will be quantified on a one percent agarose gel. A fraction of the products obtained in BSP were then analyzed with the help of qMSP.

Results: The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of methylation of genes P16, MGMT, and DAP-K as biomarkers of oral carcinoma were statistically significant. In our research, there were some very important useful findings regarding the possibility of the use of deoxyribonucleic acid methylation as a potential biomarker for the progression of premalignancy and malignancy of oral cavity, which need to be further followed up.

Conclusion: Salivary biomarkers like P16, MGMT, and DAP-K can be used in the diagnosis of oral squamous cell carcinoma.

Introduction: Dental crowding can be defined as a disparity in the relationship between the tooth size and arch length, which results in imbrication and rotation of teeth. Crowding of permanent teeth, especially in the anterior part of the mandible, is believed to be the most frequent form of malocclusion in children. The appropriate age for treatment of crowding is the late mixed dentition period.

Aim: To assess and compare the dental and skeletal factors associated with early crowding and non-crowding in children with mixed dentition. Methodology: This experimental cross-sectional study was conducted in Mangalore within 24 months. A total of sixty subjects between the age group of 7-10 years of both sexes were included in the study, in which the experimental group includes 30 subjects with mandibular crowding and the control group includes 30 subjects without lower anterior crowding. A comparison of model analysis parameters between the crowding group and the non-crowding group was done using Student's t-test. Any P-value of ≤0.05 is considered statistically significant.

Results: The result showed that dental parameters like total incisor width were greater and intercanine width was found to be reduced in the crowding group, whereas arch diameter was found to be increased in non-crowding group, which was statically significant (P-value). Skeletal parameters like SNA and SNB were found to be significantly decreased in crowding individuals (P-values of 0.011 and 0.04, respectively).

Conclusion: The total incisor width was found to be greater in the crowding group when compared to the non-crowding group, and this could be one of the reasons for the cause of crowding in the early mixed dentition period. The intercanine width and arch diameter were reduced in the crowding group when compared to the non-crowding group. Crowding in the permanent dentition may either be eliminated or at least severity can be reduced if interceptive orthodontics is initiated at an early stage in such children.