Journal of pharmacy & bioallied sciences最新文献

Introduction: The aim of the study was to assess and compare the efficacy of autotransplantation of molars with complete and incomplete root formation, by checking the viability of the procedure to replace non-restorable molar teeth in the extraction sockets.

Materials and methods: Twenty patients with non-restorable molars were included in this study. They were divided into two groups with complete and incomplete root-formed third molars, which needed to be transplanted in place of non-restorable molars. A routine surgical procedure was performed to remove infected molars. Atraumatic removal of the third molar was performed and reimplanted in the socket of previously extracted infected molars.

Results: Results were evaluated based on clinical observation and radiographic analysis of the transplanted tooth. Out of 20 transplants, one transplant, despite good initial stability, was extracted after one month because of abnormal horizontal and axial mobility; this was the single failure case (5%). Of the rest, 19/20 (95%) transplants were followed up for 6 months and showed no failure.

Conclusion: This study clearly indicated that the benefits of autotransplantation over other treatment options are numerous, and the results are not affected by whether the root of the transplanted tooth is complete or incompletely formed.

Background: A common sleep problem linked to poor cardiovascular outcomes and death is "sleep apnea (SL)." Nevertheless, little is known about how SL affects cardiovascular health in the long run. The purpose of this research was to investigate the relationship between a tertiary care center's long-term cohort's cardiovascular morbidity and mortality and the severity of their SL.

Methods: Between January 1, 2010, and December 31, 2020, 500 individuals at a tertiary care facility who had been diagnosed with SL participated in this retrospective cohort research. Electronic medical records were used to collect patient data, which were then examined for cardiovascular outcomes, treatment methods, comorbidities, sleep research findings, and demographics. Heart failure, myocardial infarction, stroke, and cardiovascular-related mortality were among the cardiovascular events that were noted throughout the follow-up period, and the severity of SL was classified using the "apnea-hypopnea index."

Findings: Of the 500 patients in the cohort, 60% were men and the mean age was 55.7 years. Fifty percent of people had one or more cardiovascular risk factors, including diabetes, high blood pressure, and smoking. During the course of the follow-up, 100 cardiovascular-related fatalities were reported, and 40% of patients had at least one cardiovascular event. The severity of SL was shown to be positively correlated with the occurrence of cardiovascular events (16.7% in mild, 25% in moderate, and 40% in severe SL, P < 0.05).

Conclusion: In a cohort of patients receiving tertiary care, this research shows a substantial correlation between the severity of SL and cardiovascular morbidity and death. It is crucial to identify and treat SL early on to reduce cardiovascular risks and enhance patient outcomes. To further understand the underlying processes and develop treatment approaches for people with cardiovascular comorbidities and SL, more research is necessary.

Aim: The present study assessed the three-dimensional bone loss, at three different levels, around implants placed immediately after extraction using the socket shield method versus immediate implant placement.

Materials and methods: A non-randomized clinical trial was conducted in 30 cases divided into two groups: socket shield method and immediate implant placement (15 cases each). Horizontal bone width (HBW) (at three different levels from baseline) and vertical bone level (VBL) (mesial and distal surfaces of the implant) were measured preoperatively and 6 months postoperatively by using cone beam computed tomography and radio visio graphy.

Results: The mean difference at 2-mm and 8-mm HBW from the baseline was better in the socket shield technique, although the results were not significant. Significant results were found in Levene's test for equality of error variances. The VBL was significant at both the distal and mesial surfaces of the implant.

Conclusion: The socket shield approach demonstrated promising clinical outcomes in preserving alveolar ridge morphology. It can be utilized as a substitute for the typical instantaneous implant placement in the aesthetic zone.

Background: This research has been conducted to assess the effect of orthodontic treatment on endodontically treated tooth.

Materials and methods: Overall, fifty subjects had been recruited. The participants received root canal therapy within 3 months as well as had an appointment for fixed orthodontic therapy. All candidates underwent an intraoral investigation. Radiographic evaluation as well as therapy planning were completed. Fixed orthodontic therapy had been initiated. All of the participants had been recalled. Endodontically restored teeth had been evaluated. All outcomes were assessed via Statistical Package for the Social Sciences (SPSS) software.

Results: In this study, there were 25 males and 25 females. Pulp stones were seen in 15 subjects. Apical periodontitis was seen in nine subjects. Apical root resorption was seen in seven subjects, and enamel decalcification was seen in four subjects. Overall, 35 out of 50 subjects showed negative effects of orthodontic treatment on endodontically treated teeth.

Conclusion: Excessive orthodontic force may result in increased pulp and peri-apical inflammation.

Background: Reducing the levels of oral microbials, including Streptococcus mutans, Candida albicans, and Lactobacilli sp., would provide the prevention of dental caries and oral illness.

Aims: To assess the antimicrobial effectiveness against oral pathogens of oral care products that contain urginea maritima extract (UM) extract, including lozenges, mouth spray, and mouthwash.

Methods: The skin irritation test was conducted on each product compared with controls in healthy participants (n = 10) by the 24-hour closed obstruction patch test. The elimination of oral pathogens in participants (n = 30) before and after product usage (as per the instruction) was assessed using a modified dip slide test.

Result: The physical appearance and stability of oral care products were almost preferable. When added to oral care products for oral health maintenance, the cariogenic bacteria S. mutans, Candida species, and Lactobacilli species have been found to exhibit antimicrobial activity.

Context: The goals of orthodontic therapy are to provide stable treatment results and the best possible tooth alignment. Orthodontic retention regimens are essential for avoiding relapses after treatment; however, there is ongoing discussion on the best regimen.

Methods: Orthodontic patients treated at a tertiary care center were the subject of a retrospective analysis. Information was gathered about follow-up evaluations, treatment techniques, patient demographics, and retention procedures. Relapse rates and occlusal characteristics were among the objective variables used to evaluate treatment stability. A statistical analysis evaluated the effectiveness of various retention strategies.

Findings: When it came to preserving treatment stability, fixed retainers outperformed detachable appliances, Hawley retainers, and Essix retainers. The mean changes in occlusal parameters and relapse rates were greater for removable appliances, but the performance of Hawley and Essix retainers was moderate. Significant variations in retention techniques were verified by statistical analysis, with fixed retainers outperforming alternative detachable retainers and removable appliances. In conclusion, compared to alternative detachable retainers and removable equipment, fixed retainers are more successful in preserving treatment stability. Retention protocols, however, must to be established with each patient's needs and treatment preferences in mind. The length of patient compliance and retention has a crucial role in determining the stability of therapy, underscoring the significance of patient education and continued monitoring. To improve long-term treatment results and optimize orthodontic retention techniques, further research and technical developments are required.

Background: In order to completely remove bacteria and debris from the root canal system, root canal treatment (RCT) calls for efficient irrigation methods. There is still a lack of research on the relative safety and efficacy of various irrigation systems in tertiary care settings.

Methods: Patients receiving RCT at a tertiary care endodontic clinic were included in a prospective comparison research of 150 subjects. One of four irrigation solutions-sodium hypochlorite, chlorhexidine, ethylenediaminetetraacetic acid (EDTA), or a combination of the three-was given to patients at random. Following surgery, microbial decrease and patient-reported pain levels were evaluated.

Results: The analysis showed that there were significant differences (P < 0.05) in microbial decrease between the irrigation solution groups. EDTA, sodium hypochlorite, and chlorhexidine were the next three groups with the biggest mean log decrease in microbial counts, after the combination group. Nonetheless, there were no appreciable variations in the groups' patient-reported pain levels (P > 0.05).

Conclusion: Our results imply that microbial reduction in RCT is highly influenced by the irrigation solution selection. Without having an impact on the pain sensations reported by the patients, the combination of irrigation solutions showed higher efficacy in microbial control. These findings highlight how crucial it is to choose an irrigation solution carefully in order to maximize endodontic outcomes in tertiary care settings.

Background: Neonatal care interventions are crucial for reducing infant mortality rates, particularly in low-resource settings where access to advanced medical facilities is limited. Implementing these interventions poses significant challenges due to resource constraints and infrastructural limitations.

Materials and methods: This clinical study investigated the challenges, successes, and strategies involved in implementing advanced neonatal care interventions in a low-resource setting. A retrospective analysis was conducted on the data collected from a neonatal care unit in a resource-limited area over a period of two years. The study assessed the availability of medical equipment, healthcare personnel training, and the efficacy of interventions in improving neonatal health outcomes.

Results: The analysis revealed that despite resource constraints, significant strides were made in implementing advanced neonatal care interventions. Availability of essential medical equipment increased by 30%, and healthcare personnel received targeted training programs resulting in a 25% improvement in neonatal survival rates. Strategies such as task-shifting and community outreach programs played a pivotal role in overcoming infrastructural limitations.

Conclusion: Implementing advanced neonatal care interventions in low-resource settings is challenging but feasible with targeted strategies. While resource constraints remain a barrier, innovative approaches such as task-shifting and community involvement can significantly improve neonatal health outcomes. Continued investment in infrastructure, training, and community engagement is essential for sustainable progress in reducing neonatal mortality rates in resource-limited areas.

Background: Both the mechanical cleansing effect and the irrigants' capacity to disintegrate tissue are necessary for irrigation to be successful. Strong antibacterial but not poisonous to the periapical tissues and increased pulp tissue dissolution irrigant are all desirable qualities in an irrigant.

Aim: To assess and compare the antibacterial properties and pulp tissue dissolving activity of various irrigation solutions.

Methods and materials: A total of 240 human mandibular permanent premolar teeth that were extracted recently for periodontal or orthodontic reasons were used in this investigation. Following irrigation, blood agar plates were used to conduct colony-forming unit (CFU) counts of the microorganism breeding colonies. Next, log CFU was computed. Before evaluating the ability of the five distinct irrigants utilized in this investigation to dissolve the frozen pulp tissues, the tissues were first smashed into smaller pieces using a mallet.

Results: The bacterial count after irrigation in category 1 (normal saline), category 2 (aqueous ozone), category 3 (ethylenediaminetetraacetic acid (EDTA)), category 4 (chlorhexidine gluconate (CHX)), category 5 (super-oxidized water), and category 6 (sodium hypochlorite (NaOCl)) was 6.08 ± 0.87 log CFU mL^-1, 0.92 ± 0.89 log CFU mL^-1, 4.15 ± 0.20 log CFU mL^-1, 3.34 ± 0.46 log CFU mL^-1, 0.21 ± 0.52 log CFU mL^-1, and 0.00 ± 0.00 log CFU mL^-1, respectively.

Conclusion: NaOCl has maximum antimicrobial reduction and pulp tissue dissolution property.

Objective: The purpose of this 5-year longitudinal study was to assess the diagnostic accuracy of panoramic radiography (PR) in identifying oral pathology at a tertiary care facility.

Methods: A retrospective review of patient files was done, encompassing those of patients who had PR for suspected oral lesions, followed by a biopsy. At various times, several diagnostic accuracy metrics were computed, such as sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic odds ratio (DOR).

Results: The research had 250 patients in total. In terms of identifying oral pathology, PR showed a sensitivity of 85% and a specificity of 90%. There were 80% and 92% PPV and NPV, respectively. With a computed DOR of 25, PR's total discriminating power was found to be high.

Conclusion: In summary, PR consistently demonstrates great diagnostic accuracy in identifying oral pathology at a tertiary care facility. These results confirm that PR is a useful screening technique for oral lesions in standard clinical practice. In order to overcome PR's shortcomings and investigate methods for enhancing its diagnostic effectiveness, more investigation is necessary.