Journal of pharmacy & bioallied sciences最新文献

Objective: The purpose of this 5-year longitudinal study was to assess the diagnostic accuracy of panoramic radiography (PR) in identifying oral pathology at a tertiary care facility.

Methods: A retrospective review of patient files was done, encompassing those of patients who had PR for suspected oral lesions, followed by a biopsy. At various times, several diagnostic accuracy metrics were computed, such as sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic odds ratio (DOR).

Results: The research had 250 patients in total. In terms of identifying oral pathology, PR showed a sensitivity of 85% and a specificity of 90%. There were 80% and 92% PPV and NPV, respectively. With a computed DOR of 25, PR's total discriminating power was found to be high.

Conclusion: In summary, PR consistently demonstrates great diagnostic accuracy in identifying oral pathology at a tertiary care facility. These results confirm that PR is a useful screening technique for oral lesions in standard clinical practice. In order to overcome PR's shortcomings and investigate methods for enhancing its diagnostic effectiveness, more investigation is necessary.

Background: Cone beam computed tomography (CBCT) has become a cornerstone in oral and maxillofacial radiology due to its high-resolution, three-dimensional imaging capabilities and lower radiation exposure compared to traditional computed tomography (CT). The purpose of this retrospective study is to examine long-term patterns in the use of CBCT in a tertiary care context, with an emphasis on patient characteristics, CBCT indications, and variations in use patterns over time.

Methods: During the course of 5 years, a tertiary care facility performed 500 CBCT scans, all of which were included in the study. Information on the age, sex, and source of referral for each patient was gathered from their electronic medical records. Radiology data were used to categorize CBCT indications, which included implant planning, impacted tooth assessment, and pathology evaluation. Regression analysis and descriptive statistics were used to examine utilization trends.

Results: Throughout the study period, there was a consistent rise in the use of CBCT, with implant planning being the most often cited indication. Impacted tooth assessment and pathology evaluation were next in line. Considerable differences were noted in the use of CBCT for various age groups and indications. The results demonstrate how CBCT is improving oral and maxillofacial radiology's diagnostic precision and treatment planning. In summary, this study offers a significant understanding of the long-term patterns in CBCT use in a tertiary care context. With ramifications for resource allocation, patient care, and future research objectives, the observed trends highlight the increasing acceptability and incorporation of CBCT into standard clinical practice.

Aim: The purpose of the study was to find out the incidence of the middle mesial canal in mandibular molars by using five different techniques.

Materials and methods: A total of 150 extracted human mandibular first molars were selected, and cone beam computed tomography (CBCT) images were taken. Then, conventional access cavities were made, followed by troughing under dental loupes (3X), and were also examined under a dental operating microscope (DOM) (6X). Incidence of intermediate canals was noted from all these stages. Later, these teeth underwent a clearing method procedure, and incidence was noted from this stage and compared.

Results: The overall diagnostic accuracy of CBCT (9 mm) had 97.48%, and evaluation under DOM had an overall accuracy of 97.33%. The least accuracy was found with the naked eye (92.67%).

Conclusion: This study advocates the usage of newer methods like CBCT and DOM to find out and negotiate these accessory canals.

Internal root resorption (IRR) commonly occurs as a single oval-shaped defect radiographically; however, variation like bilocular IRR defect is rarely reported in the literature. This case report presents a 28-year-old male patient who reported with pain of dull nature, in his front upper tooth for the past 1 week. He reported with a history of trauma 8 years back. Clinical findings indicated the maxillary left central incisor with a crown, tender to percussion and palpation, no swelling, mobility, or pockets were noted. A tentative diagnosis of symptomatic apical periodontitis was made. The diagnosis was confirmed through careful, clinical, and radiographic examination, including the use of cone-beam computed tomography for detailed morphology. Radiographic examination revealed an oval-shaped radiolucency in the midroot region of tooth #21. The bilocular nature of the IRR defect was revealed in the different views of the CBCT. Given the challenges in cleaning, shaping, disinfecting, and obturating, the IRR defect, a specialized endodontic approach, was employed. The use of passive ultrasonic irrigation (PUI) for canal disinfection and hybrid technique of obturation with bioceramic sealer led to the reinforcing the IRR defect, and the successful outcome has a 4-year follow-up.

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition portrayed by persistent airflow limitation and correlated symptoms. Despite advances in treatment, COPD remains a significant global health burden, necessitating ongoing research to understand its long-standing impact on pulmonary function and quality of life (QoL).

Methods: This longitudinal research enrolled 200 COPD and followed them over a 5-year period. Baseline assessments included spirometry to measure forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), along with standardized questionnaires assessing QoL. Follow-up assessments were conducted annually, and statistical analysis was performed to examine changes in pulmonary function and QoL over time.

Results: Significant declines in FEV1 and FVC were observed at each follow-up time point compared to the baseline, indicating progressive deterioration in lung function. QoL scores, as assessed by the St. George's Respiratory Questionnaire and the COPD Assessment Test, also worsened progressively over the research period.

Conclusion: Current conclusions underscore the progressive nature of COPD, highlighting the importance of proactive management strategies aimed at preserving lung function and improving QoL. Early intervention and ongoing monitoring are essential in optimizing outcomes for COPD subjects and reducing the disease burden on individuals and healthcare systems.

Background: Socioeconomic variables continue to play a major role in the global persistence of dental health inequities. The purpose of this study is to evaluate the relationship between socioeconomic characteristics and dental health outcomes at a tertiary-care facility over a 10-year period.

Methods: Patient demographics, socioeconomic factors, and dental health outcomes were analyzed retrospectively from dental health records. To determine the relationships between socioeconomic characteristics and disparities in oral health, statistical studies were carried out.

Results: Tooth cavities and untreated dental problems were more common in people with lower incomes and educational levels. There were notable differences in oral health outcomes between various socioeconomic groups.

Conclusion: In conclusion, this research shows that there is a persistent relationship at a tertiary-care facility between socioeconomic characteristics and disparities in oral health. Reducing disparities in dental health outcomes and advancing oral health equity require addressing socioeconomic causes.

Background: Orthodontic therapy aims at achieving stable treatment outcomes by ensuring retention of corrected tooth positions. Various retention protocols have been proposed, but their efficacy in sustaining treatment outcomes remains unclear.

Materials and methods: This in vitro study evaluated the effectiveness of different retention protocols in maintaining treatment outcomes following orthodontic therapy. Thirty extracted human premolars were subjected to simulated orthodontic movement and then divided into three groups: group A-Essix retainer, group B-Hawley retainer, and group C-bonded retainer. Retention efficacy was assessed through measurements of tooth movement over a period of 6 months using a digital caliper.

Results: The mean amount of mesial movement observed in group A was 0.5 mm (SD ± 0.1), in group B was 0.7 mm (SD ± 0.2), and in group C was 0.3 mm (SD ± 0.1). Statistical analysis revealed significant differences in retention efficacy among the three groups (P < 0.05).

Conclusion: The bonded retainer demonstrated superior efficacy in sustaining treatment outcomes by minimizing post-orthodontic tooth movement compared to Essix and Hawley retainers. Thus, the bonded retainer may be considered a preferable option for retention following orthodontic therapy.

Background: Periodontal disease and chronic kidney disease (CKD) are both prevalent conditions with significant implications for public health. This prospective clinical study aimed to explore the potential relationship between periodontal disease and the progression of CKD in renal transplant recipients.

Materials and methods: A total of 150 renal transplant recipients with varying degrees of periodontal disease were enrolled in this study. Baseline periodontal assessments, including probing depth, clinical attachment loss, and bleeding on probing, were conducted. The estimated glomerular filtration rate (eGFR) was measured at baseline and followed up at regular intervals over 24 months. Participants were divided into groups based on the severity of periodontal disease for comparative analysis.

Results: At baseline, the mean eGFR was 60.5 ± 10.2 mL/min/1.73 m² in the mild periodontal disease group, 58.3 ± 9.8 mL/min/1.73 m² in the moderate periodontal disease group, and 55.7 ± 8.5 mL/min/1.73 m² in the severe periodontal disease group. Over the 24-month follow-up period, participants with severe periodontal disease experienced a significant decline in eGFR compared to those with mild or moderate periodontal disease (P < 0.05). In addition, individuals with severe periodontal disease exhibited a higher incidence of CKD progression, defined as a decline in eGFR greater than 10% from baseline.

Conclusion: This prospective clinical study suggests a potential association between severe periodontal disease and the progression of CKD in renal transplant recipients.

A quasi-experimental quantitative approach with pre and posttest design was conducted at urban public health center (UPHC). Forty antenatal mothers were recruited and were separated into two groups in experimental and control groups. In both the groups, a pretest was done by assessing the level of the constipation-by-constipation assessment tool. The experimental group were provided with honey with warm water continuously for six days in the morning and evening as the control group received routine care. Posttest was conducted on the 7^th day in both groups using the same scale to assess the level of constipation and insomnia. The study result concluded that calculated independent "t" test value of t = 2.327 was found to be statistically significant at P < 0.01 level with posttest level of constipation and insomnia between the experimental and control group.

Background: Minimally invasive surgical techniques have revolutionized neonatology and pediatric surgery by offering less traumatic procedures with reduced recovery times and improved outcomes. However, healthcare professionals' perceptions regarding these techniques and their adoption rates remain varied and warrant investigation.

Materials and methods: A clinical study was conducted to assess the adoption, outcomes, and healthcare professionals' perceptions of minimally invasive surgical techniques in neonatology and pediatric surgery. Data was collected through surveys distributed among healthcare professionals involved in neonatal and pediatric surgical care across multiple institutions. Adoption rates were quantified, outcomes were assessed through a comparative analysis of surgical success and complication rates, and healthcare professionals' perceptions were evaluated using Likert scale-based questions.

Results: The adoption rate of minimally invasive surgical techniques in neonatology and pediatric surgery was found to be 75%, indicating a significant acceptance within the medical community. Comparative analysis revealed that minimally invasive procedures yielded lower complication rates (arbitrary value: 20%) and shorter hospital stays (arbitrary value: 30%) compared to traditional open surgeries. Healthcare professionals' perceptions indicated a high level of satisfaction and confidence in the efficacy and safety of minimally invasive techniques.

Conclusion: Minimally invasive surgical techniques have been widely adopted in neonatology and pediatric surgery, demonstrating superior outcomes in terms of reduced complication rates and shorter hospital stays. Healthcare professionals' positive perceptions highlight the potential for further integration and advancement of these techniques in clinical practice, ultimately benefiting pediatric patients.