Journal of pharmacy & bioallied sciences最新文献

This study aimed to investigate the prognostic significance of mean platelet volume (MPV) in 50 AKI patients. Blood samples were collected according to KDIGO guidelines, and complete blood counts, including MPV, were analyzed. Significant differences in MPV were observed among patients who recovered with or without dialysis and those who expired. A statistically significant difference was present in between the mean platelet count of patients recovered without dialysis, recovered with dialysis, and the expired patients. The Area Under Curve (AUC) for MPV scores was as high as 0.842. Indicating that in up to 84% of the pairs (death-survival) the models correctly estimated that the probability of survival was higher than that of death. MPV had an optimum cutoff point of score value <9.60 with a sensitivity of 80% and specificity of 91.11%. These findings suggested that MPV could serve as a cost-effective and superior tool to creatinine in early AKI detection.

The present study aimed to examine the extraction of impacted mandibular third molars by using rotatory and piezosurgery equipment. Twenty-five patients of both genders who required surgery to remove their third molars were split into two groups (control group and research group). In the surgical extraction of the impacted mandibular third molar, in the study group, a piezotome was used to remove the bone, while in the control group, a bur was used. Patients' acceptance of bone cutting, the length of the operation, discomfort and bleeding during the procedure, postoperative pain, swelling, trismus, and wound healing were evaluated. A statistically insignificant difference was observed for age and difficulty index. The intraoperative bleeding was similar in both groups. Both the groups tolerated the bone cutting well, with slightly better values for the piezo group. Based on Pederson's difficulty index, the scores of difficulty of extraction of the impacted tooth were measured between the groups. The slight difficulty was observed in 9 (36%) each in the study group and control group. The moderate difficulty in 14 (56%) of control group and 15 (60%) of study group. Severe difficulty was found among 2 (8%) in the control group and 1 (4%) in the study group. The difference was not significant (P > 0.05). Intraoral bleeding was moderately seen in 25 in both groups. Among the study and control groups respectively no intraoperative pain was seen in 14 and 16, mild intraoperative pain in 11 and 7, and moderate intraoperative pain in 0 and 2. Among group I and II acceptance to bone cutting was comfortably seen in 24 and 23, bearable in 1 and 2 respectively. The difference was not significant (P > 0.05). Piezosurgery and bur were comparable in evaluating patient acceptance, intraoperative duration, intraoperative bleeding and pain, postoperative pain, edema, trismus, and wound healing.

Introduction: The study examined mandibular premolars' root and canal distribution across genders and sides.

Materials and methods: Cone-beam computed tomography (CBCT) imaging of mandibular premolars was performed using SINORA ORTHOPHOS XG 3D, with specific parameters set.

Results: Cone-beam computed tomography (CBCT) imaging of 100 participants revealed mostly single-rooted premolars, with slight variations, notably among females. Mandibular first premolars predominantly had single canals and roots, with a higher occurrence of two canals in females. Statistical analysis showed no significant gender- or side-based differences in root distribution. The findings underscore gender-specific variations in premolar morphology, highlighting the importance of tailored treatment planning, especially for the left side.

Conclusion: While CBCT proves valuable, further research is needed to optimize its utility in endodontic decision-making.

This case-control study investigated the correlation between male infertility in India and the methylenetetrahydrofolate reductase (MTHFR) C677T variant. Infertile males were utilized as the case group in the study, whereas fertile individuals served as the control group. The C677T polymorphism was genotyped using PCR-RFLP analysis (polymerase chain reaction-restriction fragment length polymorphism). The Chi-square test and odds ratio calculation were implemented in the statistical analysis method for assessing the correlation between the C677T mutation and infertility. The results of this study revealed that the case group (9.4%) had a substantially greater prevalence of the C677T variation than the control group (1.6%). The C677T variation is significantly associated with male infertility by the Chi-square test (P value: 0.006). According to these results, the MTHFR gene›s C677T variation may increase the incidence of male infertility in the Indian population. Additional evaluations were also conducted to investigate the association between the C677T variation and particular infertility indicators. The C677T variation has been demonstrated to have been significantly correlated with a low or missing sperm count (p 0.05). These findings highlight the potential function of the MTHFR gene in reproductive health and advance our understanding of the genetic underpinnings of male infertility. It is encouraged to investigate the underlying mechanisms and additional investigation of the underlying mechanisms and to support the creation of individualized approaches to diagnosing and managing male infertility.

Objective: This research is meant to evaluate the effectiveness of different bonding agents in minimally invasive cavity preparations at a tertiary care center.

Materials and methods: A prospective research was conducted involving patients requiring minimally invasive cavity preparations. Patients were randomly assigned to groups based on the bonding agent used. Standardized cavity preparations were performed, and bonding agent application followed manufacturer instructions. Outcome measures included bond strength and marginal adaptation. Data were analyzed using appropriate statistical methods.

Results: Bonding Agent A exhibited the highest mean bond strength (25.6 MPa) and superior marginal adaptation (mean score: 4.2) compared to Bonding Agents B and C. These differences were statistically significant (P < 0.001 for bond strength, P < 0.05 for marginal adaptation).

Conclusion: Bonding Agent A demonstrated superior performance in achieving durable and esthetically pleasing restorations in minimally invasive cavity preparations. These findings underscore the importance of selecting appropriate bonding agents for conservative dental treatments to optimize treatment outcomes and patient satisfaction.

Background: One of the main risk factors for the occurrence of oral cancer is oral precancerous lesions (OPLs). Early management and preventive efforts depend on knowing the transformation rate and detecting predictive signs of malignancy.

Methods: For 6 months, a group of 200 individuals with clinically diagnosed OPLs was followed up on in this longitudinal research. To examine biomarker expression levels and describe the lesions, examinations using immunohistochemistry, histopathology, and clinical methods were carried out.

Findings: Over the course of 2 years, 200 patients with OPLs were monitored in this study. Most lesions had mild dysplasia, according to histopathological examination. The expression of many biomarkers that were correlated with the dysplasia grade were p53 (60.0%), Ki-67 (40.0%), CDKN2A (30.0%), and epidermal growth factor receptor (EGFR) (25.0%).

Conclusion: In summary, this study emphasizes how crucial it is to provide patients with OPLs with individualized care plans and routine surveillance. Certain biomarkers, such EGFR, Ki-67, and p53, can be useful prognostic markers for identifying malignant transformation. To confirm these results and create tailored therapies for high-risk patients, more study is necessary.

Background: Effective management of child behavior during dental procedures is crucial for successful treatment outcomes and promoting oral health. Parental involvement has been recognized as a key factor influencing child compliance in various healthcare settings, but its specific impact on child compliance during dental appointments remains understudied.

Methods: A cross-sectional clinical research involving 100 children scheduled for routine dental treatments. Parental involvement was categorized as high, moderate, or low based on the level of parental presence and interaction during the dental appointment. Child compliance was assessed using a validated behavior rating scale, evaluating factors such as cooperation, anxiety, and disruptive behavior during the dental procedure. Statistical analysis, including correlation analysis and ANOVA, was performed to determine the association between parental involvement and child compliance.

Results: The results revealed a significant correlation between parental involvement and child compliance (P < 0.05). Children with high levels of parental involvement demonstrated greater compliance during dental procedures compared to those with moderate or low levels of parental involvement. Specifically, children with high parental involvement exhibited lower levels of anxiety, reduced disruptive behavior, and greater cooperation with the dental team.

Conclusion: This research provides evidence of the positive impact of parental involvement on child compliance during dental procedures in pediatric patients. Higher levels of parental presence and interaction were associated with improved child behavior and cooperation, highlighting the importance of parental involvement in promoting positive oral health behaviors and facilitating successful dental treatments. These findings underscore the need for tailored interventions targeted at enhancing parental involvement and optimizing child compliance in the dental setting.

Introduction: Preservation of primary teeth is essential for optimal oral health in children; however, there is limited research on primary tooth extraction patterns in India. This study aimed to investigate the reasons for and patterns of primary tooth extraction in children in an Indian tertiary care dental setting.

Methodology: This retrospective cross-sectional study analyzed dental records of children aged up to 14 years who underwent tooth extraction under local anesthesia from January to December 2023. Demographic data, reasons for extraction, and tooth types extracted were collected and analyzed using descriptive statistics and the Chi-square test.

Results: Among the 261 subjects studied, there were 132 males and 129 females. Dental caries was the leading cause of extraction (42.6%), followed by mobility (20.8%) and over-retention (17.3%). Maxillary teeth were extracted more frequently than mandibular teeth, with central incisors being the most commonly extracted.

Conclusion: This study highlights the prevalence of dental caries as the primary reason for primary tooth extraction in Indian children. Gender-specific differences were observed in extraction reasons, and maxillary teeth were more frequently extracted than mandibular teeth. These findings emphasize the importance of targeted preventive strategies to address dental caries and promote optimal oral health in children in India.

In hemi-mandibulectomy patients, the fabrication of a successful prosthesis is a challenging task. Segmental resection of the mandible causes deviation toward the resected side resulting in facial disfigurement, difficulty in speech, mastication, swallowing, respiration, and restricted mandibular movements. Such a condition affects the daily life of the patient and might also result in a disturbed psychological state. The primary goal of treating these patients was to achieve facial aesthetics and restore function and phonetics. Such a scenario can be tackled more efficiently with good patient cooperation and a well-fabricated prosthesis.

To assess the overall impact of chlorhexidine, when used as an endodontic irrigant/medicament, on post-obturation pain following endodontic treatment by the application of Bayes methods of meta-analysis. This study aimed to combine recently documented evidence using rigorous and specific search criteria. The available data were analyzed using Bayesian methods, which have the advantage of accounting for uncertainties in estimates. This is in contrast to commonly used frequentist meta-analysis methods, which are not able to model uncertainties as effectively, particularly when there is heterogeneity present. A preliminary search was conducted in the Pubmed, Cochrane, and Scielo databases using appropriate keywords. The search aimed to identify human randomized clinical studies that evaluated post-operative endodontic pain and involved the use of chlorhexidine as an endodontic irrigant or medicament. The preliminary Bayesian meta-analysis produced a more accurate estimate compared to a frequentist random effect meta-analysis model, with a narrower credible interval. The frequentist model demonstrated a detrimental impact of chlorhexidine on post-obturation pain, while the Bayesian model indicated a somewhat favorable effect of chlorhexidine on post-obturation pain. Based on the scope of this investigation, it can be inferred that a Bayesian random effects meta-analysis model demonstrated a somewhat favorable impact of chlorhexidine on post-endodontic pain, which carries significant therapeutic significance.