Gastric cancer (GC) is a pervasive global malignancy with high mortality rates due to distant metastasis [1]. GC metastasis can occur via hematogenous route, peritoneal route, and specifically through ovarian spread in females [2]. Among these, peritoneal metastasis is the most prevalent and challenging condition to treat [3]. The Cancer Genome Atlas (TCGA) has uncovered four molecular subtypes of GC: microsatellite instability, Epstein-Barr virus-related, chromosomal instability, and genomically stable [4]. These subtypes exhibit unique features and metastatic behaviors [5], providing valuable insights into the molecular characteristics of GC. Nevertheless, there remains a gap in understanding gene expression feature in metastatic GC compared to corresponding primary tumors, particularly regarding its biological and clinical relevance in different metastatic patterns.