Bulletin Physiology and Pathology of Respiration最新文献

{"title":"Trends in tuberculosis epidemiology in the Republic of Crimea for the period 2014-2021","authors":"Z. Makhkamova, T. Golubova, I. Tkachenko","doi":"10.36604/1998-5029-2022-86-8-14","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-86-8-14","url":null,"abstract":"Aim. To assess the epidemiological situation on tuberculosis (TB) in the Republic of Crimea in 2014­2021 based on the study of morbidity, prevalence and mortality.Materials and methods. The analysis was conducted based on official data presented by the Crimean Republican Clinical Center of Phthisiology and Pulmonology.Results. During the study period in the Republic of Crimea the TB incidence decreased in 2.1 times. The downward tendency of both the incidence of all forms of TB (the growth rate is 51.7%) and pulmonary TB (growth rate is 50.2%) has been de­tected. The incidence of destructive forms of TB in Crimea reduced by 1.6 times, the proportion of destructive forms among first-time detected cases of TB was 48.2%. The peak of TB prevalence in the Republic of Crimea was in 2014 (132.1 cases per 100,000 population). In the following years there was a positive trend and by 2021 the rate decreased by 1.7 times, amounting to 77.8 cases per 100 thousand population. During the study period in the region there was a 2-fold decrease in the TB mortality rate from 17.1 in 2014 to 8.3 cases per 100 thousand population in 2021 (growth rate -51.5%). Despite the steady decrease in the mortality rate from all forms of TB in the region, there is still a stable high proportion of TB patients who died before the first year of follow-up. One of the reasons for the negative situation should be called the late diagnostics of the pathology under study, which is confirmed by the average percentage for the period 2014-2021 of untimely detected cases of TB, as well as neglected forms of TB (33.7% and 22.5%, respectively). During the period when the Republic of Crimea was a part of the Russian Federation, the financing of TB service increased by 2.1 times and, accordingly, the possibility of improving the quality and efficiency of medical care for TB patients increased, which is certainly one of the important reasons for the positive trends in improving the epidemiological situation of TB in the re­gion for the period 2014-2021.Conclusion. Over the period 2014-2021 in the Republic of Crimea, against the background of significant improvement in the financing of TB services in the region, positive dynamics in the main indicators of the epidemiological situation of TB (morbidity, prevalence and mortality) were observed. At the same time, the part of TB patients who died before the first year of follow-up remained high.","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85977744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of TRPM8 polymorphism on the progression of bronchial obstruction in patients with chronic obstructive pulmonary disease","authors":"I. Sugaylo, D. Gassan, O. Kotova, D. Naumov, Y. Gorchakova, E. Sheludko, E. Afanas'eva","doi":"10.36604/1998-5029-2022-86-15-23","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-86-15-23","url":null,"abstract":"Introduction. Chronic obstructive pulmonary disease (COPD) is a severe respiratory pathology, the main risk factor for which is tobacco smoking. The progression of bronchial obstruction is subject to individual variability which indicates an important role of genetic factors in the pathogenesis of COPD.Aim. To establish the possible effects of TRPM8 gene polymorphisms on the rate of bronchial obstruction progression in COPD patients.Materials and methods. The study included 134 COPD patients. All patients underwent genotyping of six TRPM8 gene polymorphisms by asymmetric LATE-PCR. In order to assess the rate of the disease progression post-bronchodilator spirometry was per­formed twice with an interval of one year and a decrease in FEV1 >50 ml was considered as the presence of progressive bronchial obstruction.Results. The patients were divided into two groups: the first group included patients with progression of bronchial obstruction (59 people), the second group included patients without progression of bronchial obstruction (75 people). When analyzing the relationship between the individual polymorphisms of TRPM8 gene and the severity of COPD progression it was found that the carriage of the C allele for rs11562975 polymorphism predominates in patients with pro­gressive obstruction. In the dominant model the frequency of GC+CC genotypes carriage among persons from the first group was 35.6% versus 10.7% in the second group (p=0.001). At the same time, the effect of polymorphism remained significant regardless of gender, age, pack-year index, baseline FEV1 and the exacerbations frequency (OR 3.7, 95% CI [1.29; 10.3], p=0.01). In addition, carriers of the C allele were characterized by a more significant annual decrease in FEV1 during the year compared with patients who had the GG genotype (-120.0 [-340.0; -30.0] ml/year vs. -20.0 [-130.0; 40.0] ml/year, respectively, p=0.002).Conclusion. The obtained results indicate that carriage of the C allele (genotypes GC and CC) for rs11562975 polymorphism of TRPM8 gene is a risk factor for a more severe course of COPD with a progressive decrease in FEV1.","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79428994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil extracellular traps in the pathogenesis of obstetric complications in COVID-19 (brief review)","authors":"O. Zhukovskaya","doi":"10.36604/1998-5029-2022-85-143-150","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-85-143-150","url":null,"abstract":"Introduction. In the pathogenesis of the new coronavirus infection (COVID-19), innate cellular elements of the immune system are of great importance, among which special attention is paid to neutrophils and the mechanisms of their death – netosis, which leads to the formation of extracellular DNA traps. Neutrophil extracellular traps play an important role in the development of endothelial dysfunction and thrombotic disorders, which not only complicates the course of COVID-19 infection, but also causes severe obstetric complications that increase the risk of maternal and infant mortality. This review describes possible mechanisms for the formation of neutrophil extracellular traps, as well as their role in the pathogenesis of COVID-19.Materials and methods. An analysis of Russian (eLibrary) and foreign (PubMed) literature was carried out with a search depth of 2010-2021.Results. The pathogenesis of COVID-19 is directly related to the uncontrolled progression of systemic inflammation, which changes the innate immune response in the form of functional maladaptation and premature death of neutrophils with the formation of neutrophil extracellular traps. The neutrophils that were transformed by netosis play a key role in the development of thrombotic disorders of the microvasculature, which leads to the development of life-threatening complications such as acute respiratory distress syndrome and multiple organ failure, which increases the mortality of patients with COVID-19 infection. During pregnancy, increased formation of neutrophilic extracellular traps is the cause of hemodynamic disturbances of the fetoplacental complex, placental disorders and endothelial dysfunction, concomitant with the development of preterm labor and preeclampsia, which increases the risk of postpartum hemorrhage, maternal morbidity and mortality. Therefore, new data on neutrophil extracellular traps and mechanisms of formation may lead to a reconsideration of the pathogenesis of thrombotic disorders in pregnant women with COVID-19 infection, which is important for further management of pregnancy.","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72903292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathomorphological characteristics of cotyledons with weak contrasting of the blood flow in the placenta of women who have undergone exacerbation of cytomegalovirus infection during the second trimester of pregnancy","authors":"I. Gorikov","doi":"10.36604/1998-5029-2022-85-100-107","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-85-100-107","url":null,"abstract":"Aim. To give pathomorphological characteristics of placental cotyledons with weakly contrasted bloodstream in women who had an exacerbation of cytomegalovirus infection (CMVI) in the second trimester of pregnancy.Materials and methods. A study was made of involutive-destructive processes in 153 cotyledons of the placenta with well and weakly contrasted bloodstream in women with pregnancy, uncomplicated and complicated by exacerbation of CMVI at 21-24 weeks of gestation. The first group included 36 cotyledon placentas from women with CMV-seronegative uncomplicated pregnancy with well contrasted blood vessels; the second group – 67 cotyledon placentas from patients with chronic compensated placental insufficiency (CCPI) and poorly contrasted vascular network; the third group – 30 cotyledon placentas from women with chronic subcompensated placental insufficiency (CSPI) with indistinctly visualized blood vessels; the fourth group – 20 cotyledon placentas from patients with chronic decompensated placental insufficiency (CDPI). Dosed introduction of red lead on drying oil (1:3) into the blood vessels of the placenta was carried out through the umbilical cord vein. Obtaining X-ray images of cotyledons with well and weakly contrasted blood vessels in the marginal part of the organ was carried out on the apparatus RUM-20M with X-ray image intensifier Sapphire (Russia). Cotyledon biopsy specimens for histometry and histochemical analysis were taken before their contrasting, and for survey microscopy – after injection of the contrast mass.Results. In the first group, the amount of fibrinoid in the stroma of the villi was 1.35±0.09%, perivillous fibrinoid − 1.02±0.08% in the absence of pseudonecrosis and calcifications. In the second group, unlike the first one, cotyledons prevailed, in which in 40-50% of cases weakly expressed contours of blood vessels were found, an increase in the specific volume of stromal fibrinoid by 1.82 times was observed (p<0.001), and fibrinoid around villi by 2.04 times (p<0.001); pseudonecrosis accounted for 2.29±0.13%, and calcificates − 1.50±0.12%. In the third group, in comparison with the second one, cotyledons were more common with 50-70% of indistinctly contoured vessels, villi with edematous changes and stromal collagenization; the concentration of stromal fibrinoid increased by 1.47 times (p<0.001), the proportion of perivillous fibrinoid – 1.46 times (p<0.001), pseudonecrosis – 1.41 times (p<0.001) and the accumulation of calcium salt – 1.57 times (p<0.001). In the fourth group, compared to the third one, cotyledons were more common, in which more than 70% of weakly contrasted blood vessels were determined, while the number of collagen fibers and acid glycosaminoglycans increased in the villi; there was an increase in the amount of fibrinoid around the villi by 1.24 times (p<0.01), pseudonecrosis – by 1.23 times (p<0.05) and calcificates – by 1.32 times (p<0.01).Conclusion. In women with an exacerbation of CMVI in the se","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88938602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusing capacity of lungs in chronic obstructive pulmonary disease: gender, age, and race aspects","authors":"O. Kytikova, M. Antonyuk, T. Gvozdenko, T. Novgorodtseva","doi":"10.36604/1998-5029-2022-85-116-130","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-85-116-130","url":null,"abstract":"Introduction. Diffusion capacity of lungs is the second most important respiratory test after spirometry. The importance of assessing lung diffusion capacity in chronic obstructive pulmonary disease (COPD) is not given due attention, although this parameter reflects changes in functional lung volume and gas transport through the alveolar-capillary membrane, thereby providing more information about respiratory physiology than spirometry results. Diffusing capacity of the lung for carbon monoxide (DLCO) measurement is the standard in pulmonology, however, in recent years, close attention has been given to the determination of lung diffusion capacity for nitric oxide (DLNO), which gives better explanation of gas transport through the alveolar-capillary membrane compared to DLCO. Recent literature is actively discussing the inclusion of age, race, and gender aspects in spirometric reference equations that are used to assess spirometric parameters and lung diffusion capacity.Aim. To analyze the literature over the past five years, reflecting the views of modern researchers on methods for diagnosing lung diffusion capacity, as well as the contribution of age, race, and gender aspects to the assessment of this parameter in COPD.Materials and methods. The PubMed database was searched for information for the period 2017-2022 according to the selected inclusion criteria. Information requests included the following set of keywords: “diffusion capacity”, “chronic obstructive pulmonary disease”, “gender”, “age”, “race”, “DLNO”, “DLCO”. 123 articles were analyzed.Results. Recent evidence highlights the importance of including lung diffusivity in COPD prognostic programs. Determining the diffusion capacity of the lungs for nitric oxide may be a promising area of research soon. Gender and age considerations play an important role in the interpretation of spirometry data and lung diffusion capacity. The issue of including a racial trait in the assessment of the diffusing capacity of the lungs in COPD is in doubt.","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80476008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation of pneumomediastinum in a case of severe COVID-19-associated pneumonia in a teenager","authors":"E. Knizhnikova, G. Evseeva, S. A. Cherezov, T. M. Adlivankina, R. Telepneva, S. Suprun, O. Lebedko","doi":"10.36604/1998-5029-2022-85-108-115","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-85-108-115","url":null,"abstract":"Aim. Demonstration of the clinical case of pneumomediastinum in a teenager with severe COVID-19- associated pneumonia.Materials and methods. The clinical case of spontaneous pneumomediastinum was presented, which was a complication of the severe course of COVID-19 pneumonia in a teenager.Results. Patient Ch., 15 years old, with obesity of the 1st degree, was admitted to the hospital of infectious diseases for patients with a COVID-19 on the 7th day of the illness in a severe condition and had complaints of an increase in body temperature to 40ºC, pronounced cough and weakness, dyspnea when walking and at rest. The PCR test for SARS-CoV-2 gave a positive result. Multispiral computed tomography showed polysegmental interstitial lesion of both lungs, which had multiple areas of “ground glass”, signs of pneumomediastinum, subcutaneous emphysema of the upper third of the chest, left-sided pleural effusion. The volume of lung tissue lesion was 50% on the right and 85% on the left. The positive effect of treatment was not observed after 2-3 days in the hospital. The condition of heavy severity continued due to intoxication syndrome, respiratory failure, inflammatory changes in lung tissue syndrome. In this regard, the patient was injected intravenously with tocilizumab (Actemra®) 400 mg. The child was released on the 20th day of hospitalization with a positive clinical effect.Conclusion. The above clinical case demonstrates that in children a novel coronavirus infection can occur not only in severe form, but also with the possible development of complications in the form of pneumomediastinum and low effectiveness of antibacterial and antiviral therapy, which required the use of humanized monoclonal antibodies (tocilizumab).","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90588227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibilities of respiratory rehabilitation in correction of small airway dysfunction","authors":"N. S. Yubitskaya, M. Antonyuk, T. Gvozdenko","doi":"10.36604/1998-5029-2022-85-131-142","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-85-131-142","url":null,"abstract":"Introduction. It is now recognized that small airway dysfunction is a component of the development of chronic obstructive diseases. The damage of the small airways is characteristic of certain phenotypes of bronchial asthma and chronic obstructive pulmonary disease, which determines the characteristics of the clinical manifestations of the disease and requires a personalized approach to treatment.Aim. Summarizing the data of domestic and foreign researchers on the possibility of using non-drug methods of rehabilitation of chronic obstructive diseases in terms of their impact on the small airways.Materials and methods. The review uses data from articles published in PubMed, Google Scholar, eLIBRARY.Results. The article presents modern methods for assessing small airways. The choice of criteria and the complexity of diagnosing small airway dysfunction at the stage of rehabilitation treatment are discussed. The effectiveness of the use of natural and preformed physical factors in the rehabilitation treatment of chronic obstructive pulmonary diseases has been shown. The authors analyze the influence of physiotherapeutic factors on the dynamics of spirometry parameters, indirectly indicating the state of small airways. The preferred choice of inhalation preparations with extrasmall sizes of medicinal particles penetrating into the distal respiratory tract is shown. The influence of natural and preformed physical factors on the small airway dysfunction in chronic obstructive pulmonary diseases is highlighted.Conclusion. Literature data suggest a positive effect of pulmonary rehabilitation methods on the small airway dysfunction. Further studies are required to study the mechanisms of action of physiotherapeutic factors on the peripheral parts of the respiratory tract and the development of targeted medical technologies.","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87530540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of COVID-19 clinical course among vaccinated against SARS-CoV-2 people in the Khabarovsk krai","authors":"E. Bazykina, O. Trotsenko, T. Zaitseva, T. Karavyanskaya","doi":"10.36604/1998-5029-2022-85-19-25","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-85-19-25","url":null,"abstract":"Aim. To analyze clinical manifestations of novel coronavirus infection among vaccinated population of the Khabarovsk krai with breakthrough infection.Materials and methods. Analysis was based on official data including information on COVID-19 breakthrough infections provided by Khabarovsk krai Rospotrebnadzor regional office. Statistical analysis included calculation of Spearman's rank correlation, odds ratio.Results. A relatively small proportion (0.7%) of breakthrough COVID-cases that occurred among Khabarovsk residents vaccinated against SARS-CoV-2 was shown during analyzed period of time. The highest risk of contracting COVID-19 was revealed among people aged over 50 years. Course of breakthrough COVID-19 infection was mostly mild ‒ 61.0% (95% CI: 54.2‒67.6%). In most cases COVID-19 manifested itself as acute respiratory viral infection ‒ 66.7% (95% CI: 60.0‒73.0%). A significant negative correlation was noted between levels of blood saturation and duration of the disease (ρ=-0.82; p<0.05). Duration of COVID- 19 among vaccinated people was 16 days in for patients treated in an outpatient facility and 17 days for hospitalized patients in average. Most common clinical manifestations of COVID-19, noted by more than half of the respondents, were hyperthermia ‒ 55.7% (95% CI: 48.8–62.5%), weakness and cough ‒ 65.7% each (95% CI: 59.1–72,2%).Conclusion. Obtained data testify in favor of significant protective potential of vaccines against COVID-19.","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89662662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in immunological parameters and umbilical blood flow in pregnant women during exacerbation of chronic bronchitis associated with cytomegalovirus infection","authors":"L. Nakhamchen, V. Kolosov, I. Gorikov, I. Andrievskaya, N. A. Ishutina, A. Odireev, A. V. Bushmanov, T. Smirnova, E. Karapetyan","doi":"10.36604/1998-5029-2022-85-91-99","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-85-91-99","url":null,"abstract":"Aim. To evaluate changes in immunological parameters and umbilical blood flow in pregnant women with exacerbation of chronic bronchitis associated with cytomegalovirus infection (CMVI).Materials and methods. The concentration of secretory immunoglobulin A (sIgA), immunoglobulin E (IgE), circulating immune complexes (CIC), interleukin- 6 (IL-6), interleukin-4 (IL-4) and systolic-diastolic ratio (SDR) in the umbilical artery was studied in 80 women with exacerbation of chronic bronchitis in the second trimester of pregnancy, uncomplicated and complicated by the acute phase of CMVI. The first group was represented by 30 women with cytomegalovirus seronegative physiological pregnancy; the second – 25 patients with exacerbation of chronic bronchitis caused by reactivation of CMVI, complicated by the development of chronic compensated placental insufficiency (CCPI); the third – 25 women with chronic simple bronchitis in the acute stage in the setting of the acute phase of CMVI, initiating the formation of chronic subcompensated placental insufficiency (CSPI) at 30-34 weeks of gestation.Results. In the first group, the concentration of sIgA in blood serum was 4.3±0.26 mg/L, IgE – 3.64±0.23 IU/mL, CIC – 0.091±0.005 AU, IL-6 – 2.41±0.21 pg/mL, IL-4 – 30.1±2.19 pg/mL, cortisol – 527.2±20.95 nmol/L, and SDR in the artery umbilical cord – 3.41±0.06 relative units. In women of the second group, in comparison with the first one, there was an increase in the concentration of sIgA by 1.40 times (p<0.01), IgE – by 1.95 times (p<0.001), CIC – by 1.83 times (p<0.001) , IL-6 – 2.61 times (p<0.001), IL-4 – 1.29 times (p<0.05), cortisol – 1.35 times (p<0.001) in the absence of statistically significant differences the magnitude of vascular resistance in the umbilical artery. In the third group, in comparison with the first one, there was a decrease in sIgA values by 1.26 times (p<0.05) in the setting of an increase in the concentration of IgE by 2.56 times (p<0.001), CIC – by 2.09 times (p<0.001 ), IL-6 – by 3.65 times (p<0.001), IL-4 – by 1.64 times (p<0.001), cortisol – by 1.52 times (p<0.001) and SDR in the umbilical artery – 1.27 times (p<0.001). In women of the third group, in contrast to the second one, a decrease in the concentration of sIgA by 1.77 times (p<0.001), as well as an increase in IgE by 1.31 times (p<0.01), CIC ‒ by 1.14 times (p<0.001), IL-6 ‒ 1.39 times (p<0.001), IL-4 ‒ 1.27 times (p<0.05), cortisol ‒ 1.13 times (p<0.05) and SDR in the umbilical artery ‒ 1.21 times (p<0.001). A direct correlation was established between IL-6 and cord blood flow (r=0.53; p<0.01), as well as an inverse relationship between sIgA and cortisol (r=-0.44; p<0.05).Conclusion. In the second trimester of gestation, exacerbation of chronic simple bronchitis caused by reactivation of CMVI, which initiates the development of CSPI, in contrast to chronic bronchitis in the acute stage, associated with the acute phase of chronic CMVI, which induces the formation of CCPI, is acco","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72633461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of chronic obstructive pulmonary disease biomarkers using ROC-analysis","authors":"T. I. Vitkina, E. Kondratyeva","doi":"10.36604/1998-5029-2022-85-32-36","DOIUrl":"https://doi.org/10.36604/1998-5029-2022-85-32-36","url":null,"abstract":"Aim. To identify key diagnostic criteria for chronic obstructive pulmonary disease (COPD).Materials and methods. We examined 112 patients with mild, moderate and severe COPD and 32 relatively healthy volunteers with no disturbances in the lung function. The level of IL-4, IL-6, IL-10, IL-17A, TNF-α, IFN-γ, TGF-β1 and CD4+CD126+ cells was determined by means of flow cytometry method. Prooxidant and antioxidant markers of oxidative stress 8-OHdeoxyguanosine, protein carbonyl, glutathione, glutathione reductase, glutathione peroxidase, thioredoxin-1, and thioredoxin reductase-1 were assessed by enzyme immunoassay.Results. The presence of high-ranking correlations of the proinflammatory link of immunity and components of the prooxidant system was revealed, which indicates the presence of systemic alterative processes in patients with COPD. Based on ROC-analysis, key biomarkers were identified in patients with stable COPD: 8-OH-deoxyguanosine, CD4+CD126+ cells, IL-17, and thioredoxin, and their threshold levels were established.Conclusion. The recommended diagnostic criteria will optimize the therapeutic strategies for COPD.","PeriodicalId":9598,"journal":{"name":"Bulletin Physiology and Pathology of Respiration","volume":"360 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82913365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}