Carbohydrate Polymer Technologies and Applications最新文献

{"title":"Tunable chemotherapy release using biocompatible fatty acid-modified ethyl cellulose nanofibers","authors":"Michael Wildy ,&nbsp;Qiangjun Hao ,&nbsp;Wanying Wei ,&nbsp;Duc Huy Nguyen ,&nbsp;Kai Xu ,&nbsp;John Schossig ,&nbsp;Xiao Hu ,&nbsp;David Salas-de la Cruz ,&nbsp;Dong Choon Hyun ,&nbsp;Zhihong Wang ,&nbsp;Ping Lu","doi":"10.1016/j.carpta.2025.100670","DOIUrl":"10.1016/j.carpta.2025.100670","url":null,"abstract":"<div><div>Localized stimuli-responsive delivery systems for chemotherapy drugs have the potential to revolutionize therapeutic outcomes by offering greater selectivity, thereby reducing systemic side effects and bolstering patient benefits. In this work, ethyl cellulose (EC) nanofibers were prepared using electrospinning, encapsulating both doxorubicin HCl (DOX) and Rhodamine B (RhB) as representative hydrophilic chemotherapy and model drugs, respectively, and lauric acid (LA) as a biocompatible phase change material (PCM). <em>In vitro</em> release profiles demonstrated a distinct temperature-dependent release pattern: a noteworthy 27 % increase in release for DOX at pH 7.4 at 40 °C compared to 37 °C after 96 h Additionally, the release mechanism of DOX showcased pronounced pH sensitivity, evidenced by an increase of 41 % in release after 96 h at pH 4 when the temperature was increased from 37 °C to 40 °C, combined with a noticeable reduction of burst release. Furthermore, cytotoxicity assay indicated the prolonged efficacy of the DOX-embedded nanofibers, underscoring their therapeutic potential. Advanced analytical techniques, such as DSC, XRD, and FTIR, revealed an amorphous state of the drugs and a harmonious PCM integration. Our EC drug delivery system (DDS) demonstrated potential for targeted, stimuli-responsive DOX release, which could revolutionize its traditional administration, particularly in post-surgical scenarios to prevent tumor recurrence.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100670"},"PeriodicalIF":6.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carboxymethyl cellulose/copper complex/Rhazya stricta bio-nanocomposite based on barley stem wastes for anticancer and biomimetic catalytic application","authors":"Farideh Hydari ,&nbsp;Amir Sh. Saljooghi ,&nbsp;Atena Naeimi","doi":"10.1016/j.carpta.2025.100667","DOIUrl":"10.1016/j.carpta.2025.100667","url":null,"abstract":"<div><div>Molecular weight and degree of substitution of extracted sodium carboxymethyl cellulose (CMC) from barley stem wastes were assessed. A novel bio-nanocomposite, CMC/Cu@RS, was developed in the presence of CMC, a copper complex, and <em>Rhazya stricta</em>. This bio-nanocomposite was characterized by techniques such as X-ray photoelectron spectroscopy (XPS), dynamic light scattering (DLS), zeta potential analysis, nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), UV–visible spectroscopy, and fourier-transform infrared spectroscopy (FT-IR). The anticancer properties of <em>Rhazya stricta</em>, Paclitaxel, and the CMC/Cu@RS bio-nanocomposite were evaluated against the human breast cancer cell line MCF-7 using the MTT assay. The cytotoxicity of the CMC/Cu@RS bio-nanocomposite was significantly lower compared to <em>Rhazya stricta.</em> Additionally, the cellular uptake of the CMC/Cu@RS bio-nanocomposite by MCF-7 cells was investigated through fluorescence microscopy. It seems that the nanocomposite was absorbed and penetrated the cancer cells. The catalytic activity of bio-nanocomposite was considered as a nano-catalyst for the oxidation of alcohols using hydrogen peroxide in aqueous conditions. The excellent conversions and selectivities were gained in this green strategy. This straightforward synthesis of the nanocomposite from agricultural waste, coupled with its significant anticancer and catalytic activities, underscored its potential for both the environmentally friendly processes and the sustainability initiatives.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100667"},"PeriodicalIF":6.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histidine-tagged dialdehyde cellulose nanoparticles to study the co-treatment effect of curcumin and 3-methyladenine on HepG2 cells","authors":"Sheyda Sharifi ,&nbsp;Effat Alizadeh ,&nbsp;Sevil Vaghefi Moghaddam ,&nbsp;Fereshteh Rahdan ,&nbsp;Roya Herizchi ,&nbsp;Leila Alidoust ,&nbsp;Parvaneh Keshavarz","doi":"10.1016/j.carpta.2025.100664","DOIUrl":"10.1016/j.carpta.2025.100664","url":null,"abstract":"<div><div>The anticancer effects of curcumin (CUR) against hepatocellular carcinoma (HCC) cells have been well-documented. However, poor solubility limits its use in clinical practice. Natural delivery systems could help to overcome this restriction and reduce adverse effects on normal cells during cancer therapy. Besides, modification of carriers by amino acids can enhance their potential to enter and release payloads. For instance, histidine (His) not only induces pH responsivity but also protonated His inside the endosomes will possibly undergo endosomal bump and release of cargos in tumor cells. In addition, the small molecule 3-methyladenine (3-MA) has been reported to influence tumor control by altering autophagy in cells. This study intended to develop a pH-responsive nanocarrier based on dialdehyde cellulose (DAC) nanoparticles (NPs) to enhance the bioavailability and controlled release of CUR in HepG2 cells. Also, we add 3-MA to the culture media to evaluate their synergistic effect and autophagy inhibition. The physicochemical evaluations of NPs and the release kinetics studies showed proper fabrication as well as controlled and smart release of CUR from NPs. We found that combining CUR/DAC<img>His with 3-MA could stimulate autophagy and had a synergistic effect on HepG2 cells (<em>p</em> &lt; 0.05) while representing negligible toxic effects on normal fibroblasts.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100664"},"PeriodicalIF":6.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetone gas sensor based on chitosan-metal-organic framework mixed matrix membranes for diabetes diagnosis","authors":"Lamia A. Siddig ,&nbsp;Ashraf Ali ,&nbsp;Shaikha S. Al Neyadi ,&nbsp;Yaser E. Greish ,&nbsp;Stefan Wuttke ,&nbsp;Saleh T. Mahmoud","doi":"10.1016/j.carpta.2025.100661","DOIUrl":"10.1016/j.carpta.2025.100661","url":null,"abstract":"<div><div>Detecting diabetes in its early stages through non-invasive methods remains a major challenge for researchers. One promising approach involves the development of a rapid and sensitive chemiresistive sensor to measure acetone levels in exhaled breath-a potential biomarker for diabetes. In this study, we successfully fabricated a novel composite sensor comprising chitosan, a linear polysaccharide, combined with a metal-organic framework (UiO-66-NH₂ MOF) and the ionic liquid glycerol. This combination enhances the film-forming properties of the material, leveraging the MOF's high surface area and selective adsorption capabilities for superior performance.</div><div>The sensor was designed to detect acetone through chemiresistive sensing and demonstrated remarkable response to acetone concentrations as low as 1 ppm. Operating at a low temperature of 60 °C with a bias voltage of 4 V, the sensor exhibited excellent functionality even in high-humidity environments. Furthermore, it showed good repeatability, long-term stability, and fast response and recovery times of 23 ± 0.25 s and 18 ± 0.1 s, respectively.</div><div>These characteristics make the sensor suitable for biomedical applications. Its flexibility and eco-friendly design further underscore its potential as a real-time breath analyzer for diabetes detection. The results of this study suggest a promising pathway for future clinical implementation of this technology.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100661"},"PeriodicalIF":6.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transparent, flexible, and glycerol-free TEMPO-oxidized starch/montmorillonite nanocomposites with high mechanical strength and high anti-UV properties","authors":"Chun-Nan Wu,&nbsp;Hsi-Mei Lai","doi":"10.1016/j.carpta.2025.100663","DOIUrl":"10.1016/j.carpta.2025.100663","url":null,"abstract":"<div><div>The transparent, flexible, and glycerol-free 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized starch (OS) films were first successfully prepared using the TEMPO/NaClO/NaClO₂ system. The OS05 film (degree of oxidation 5 %, ∼33 μm in thickness) exhibited high transparency (89–91 % light transmittance at 400–700 nm), superior mechanical properties (Young's modulus of 1.6 GPa, tensile strength of 42.4 MPa), anti-UV property (light transmittance &lt;26 % at 200–275 nm), and low water vapor permeability (1.81 × 10^–10 g m^–1 s^–1 Pa^–1). After incorporating 2.5 % montmorillonite (MMT) to form the OS05M2.5 composite film, transparency was maintained, and all other properties improved, particularly Young's modulus (1.8 GPa) and anti-UV property (&lt;16 %). XRD results show the <em>d</em>-spacing of MMT nanoplatelets increased from ∼1 to ∼1.9 nm after combining with OS, indicating successful intercalation of OS molecules into MMT interlayers, consistent even with 10 % MMT content. The effective modulus of MMT nanoplatelets in the OS matrix was determined to be 18.5 GPa. Based on the experimental evidence, the biodegradable OS05 and OS05M2.5 films are promising candidates for transparent packaging materials.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100663"},"PeriodicalIF":6.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recyclable nano-CuI immobilized on UiO-66-NH2 coated with porous sodium alginate-polysulfonamide for synthesis of phenols","authors":"Samaneh Koosha ,&nbsp;Ramin Ghorbani-Vaghei ,&nbsp;Sedigheh Alavinia","doi":"10.1016/j.carpta.2025.100665","DOIUrl":"10.1016/j.carpta.2025.100665","url":null,"abstract":"<div><div>Buchwald-Hartwig reaction for phenol synthesis is an important tool in organic chemistry, offering a reliable and versatile method for constructing aryl ether linkages, which are prevalent in many natural products, pharmaceuticals, and advanced materials. This research presented a recyclable environmentally-friendly catalyst for the synthesis of phenols from the reaction of aryl halides and sodium hydroxide. For this purpose, we synthesized porous functionalized sodium alginate based polymer (porous sodium alginate-polysulfonamide, SA-PS) immobilized on the surface of UiO-66-NH₂ (UiO-66-NH₂@SA-PS). Finally, copper iodide nanoparticles were then introduced, resulting in the formation of UiO-66-NH₂-supported porous sodium alginate-polysulfonamide-copper iodide nanocatalyst (UiO-66-NH₂@SA-PS/CuI). Successful functionalizations were confirmed through FT-IR and XRD analyses. FESEM images revealed spherical sodium alginate particles and TEM analysis indicated a core-shell structure. ICP data confirmed the anchoring of 0.67 mol% of copper iodide. The nanocatalyst UiO-66-NH₂@SA-PS/CuI demonstrated exceptional performance in Buchwald-Hartwig reaction, facilitating high product yields in the cross-coupling of various aryl halides, and sodium hydroxide under mild conditions. Furthermore, the catalyst displayed the ability to be reused up to six times without significantly reducing productivity, proving its environmental friendliness and sustainability in promoting the creation of C<img>O bonds in organic synthesis. This versatile nanocatalyst holds promising for efficient and economically viable catalysis in diverse chemical applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100665"},"PeriodicalIF":6.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inclusion complex of water-soluble arbutin with β-cyclodextrin: Computer modeling and experimental studies","authors":"Narin Paiboon ,&nbsp;Supawan Rujipairoj ,&nbsp;Suvimol Surassmo ,&nbsp;Uracha Rungsardthong Ruktanonchai ,&nbsp;Sarunya Phunpee ,&nbsp;Saba Ali ,&nbsp;Nitchakan Darai ,&nbsp;Thanyada Rungrotmongkol ,&nbsp;Apinan Soottitantawat","doi":"10.1016/j.carpta.2025.100662","DOIUrl":"10.1016/j.carpta.2025.100662","url":null,"abstract":"<div><div>A water-soluble arbutin was investigated for its potential to form an inclusion complex with β-cyclodextrin (β-CD). Molecular modeling tests confirmed that arbutin can be accommodated within the cavity of β-CD primarily through Van der Waals forces rather than electrostatic interactions. The structure of the arbutin-β-CD inclusion complex was characterized using Differential Scanning Calorimetry (DSC), and Proton Nuclear Magnetic Resonance Spectroscopy (¹H NMR). The inclusion complex prepared at a mole ratio of 1:1 (arbutin: β-CD) exhibited the highest encapsulation efficiency at 43.72 %. The study findings affirm that encapsulation of arbutin within β-CD does not reduce its inherent antioxidant activity and its inhibitory effects against tyrosinase enzyme activity. Moreover, the complexation of arbutin with β-CD resulted in a notably slower release rate, indicating the role of β-CD in modulating substance release kinetics. Furthermore, encapsulation of arbutin within β-CD demonstrated a reduction in hydrolysis from arbutin to hydroquinone by <em>Staphylococcus epidermidis</em>, highlighting the potential of the inclusion complex to mitigate enzymatic conversion processes.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100662"},"PeriodicalIF":6.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cu(II) supported on crosslinked chitosan-cellulose beads as efficient and recyclable catalysts for oxidative self-coupling of amines to imines","authors":"Waranya Limprasart ,&nbsp;Jariyaporn Sangkaworn ,&nbsp;Sirichok Paosopa ,&nbsp;Soraya Pornsuwan ,&nbsp;Thanthapatra Bunchuay ,&nbsp;Jonggol Tantirungrotechai","doi":"10.1016/j.carpta.2024.100660","DOIUrl":"10.1016/j.carpta.2024.100660","url":null,"abstract":"<div><div>To address environmental and sustainability goals, catalytic processes must be efficient, economical, and practical. Chitosan-supported metal catalysts face challenges in mechanical strength and chemical stability, which can be improved by crosslinking and blending with cellulose. This study developed Cu(II) supported crosslinked chitosan-cellulose beads as a cost-effective and sustainable catalyst for green synthesis of imines, focusing on mechanical robustness to extend catalyst lifetime. The catalyst beads were prepared by mixing medium molecular weight chitosan and microcrystalline cellulose in HCl solution (2:1 w/w), crosslinking with 0.17 wt.% glyoxal, and depositing copper using 30 mM Cu(OAc)₂ solution. The interactions between Cu(II) ions and the crosslinked chitosan-cellulose matrix were investigated. The Cu(II) species formed a stable square planar geometry, coordinating with oxygen and nitrogen donor atoms in the crosslinked matrix. The resulting structure combined the strength of cellulose with the chemical stability provided by glyoxal crosslinking, outperforming pure chitosan in mechanical strength and stability. The Cu/chitosan-cellulose beads catalyzed the oxidative self-coupling of amines to imines (14 examples), achieving yields of 45–97 % and retaining activity over 13 cycles with simple separation and recycling. Therefore, this Cu-based catalyst, with its robust structure and bead form, is a promising option for sustainable and efficient synthesis of imines.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100660"},"PeriodicalIF":6.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of alginate oligosaccharides on the growth performance, hepatocyte health, and intestinal inflammation of the Chinese sea bass (Lateolabrax maculatus)","authors":"Shengzhe An ,&nbsp;Wei Yu ,&nbsp;Xiaolin Huang ,&nbsp;Yukai Yang ,&nbsp;Keng Yang ,&nbsp;Chuanpeng Zhou ,&nbsp;Pengwei Xun ,&nbsp;Liqin Han ,&nbsp;Heizhao Lin","doi":"10.1016/j.carpta.2024.100658","DOIUrl":"10.1016/j.carpta.2024.100658","url":null,"abstract":"<div><div>In this study, the effects of alginate oligosaccharides (AOS) on the growth performance and health of the Chinese sea bass (<em>Lateolabrax maculatus</em>) were evaluated. Six trial diets (0.00 %, 0.03 %, 0.06 %, 0.09 %, 0.12 %, and 0.15 % AOS) were formulated and fed to Chinese sea bass larvae (body weight 8.16 ± 0.11 g) for 56 days. The results showed that the growth performance of fish fed with diets containing 0.09–0.15 % AOS were significantly higher than that with the control diet. The activities of alkaline phosphatase, glutathione peroxidase, peroxidase, and lysozyme were significantly higher in fish fed with diets containing AOS than in those in the control group; however, the plasma triglyceride concentrations of fish were decreased. Dietary AOS with 0.06–0.15 % activated the <em>Keap1-Nrf2</em> signaling pathway and enhanced the antioxidant and anti-inflammatory capacities of the fish. Simultaneously, it promoted the expression of genes related to lipid metabolism and inhibited cell apoptosis. Conclusively, this study reveals that dietary AOS improves the growth performance, lipid metabolism, antioxidant capacity, apoptosis, and immunity of the Chinese sea bass.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100658"},"PeriodicalIF":6.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of glucomannan molecules derived from Porang (Amorphophallus muelleri Blume) flour by various purification process and the optical transparency","authors":"Ivan Rizoputra ,&nbsp;Sriati Wahyudi ,&nbsp;Sudarsono ,&nbsp;Diky Anggoro ,&nbsp;Niniek Fajar Puspita ,&nbsp;Risdiana ,&nbsp;Darminto","doi":"10.1016/j.carpta.2024.100659","DOIUrl":"10.1016/j.carpta.2024.100659","url":null,"abstract":"<div><div>Porang flour derived from porang tubers (<em>Amorphophallus muelleri</em> Blume) of the <em>Araceae</em> family and has contains high levels of glucomannan, ranging between 15 and 64% dry weight. Furthermore, porang flour includes oxalic acid, especially potassium oxalate monohydrate (K₂C₂O₄.H₂O), which is unnecessary in many applications due to it is hazardous to organisms. As a result, purification methods porang flour is a crucial step in removing these harmful chemicals. Therefore, the purpose of this research is to identify the chemical components of glucomannan and potassium oxalate monohydrate in porang flour samples before and after purification, as well as to investigate potential applications. Purification was accomplished using centrifugation and soaking for 30 minutes and 7 days. Furthermore, the content of glucomannan and potassium oxalate monohydrate in porang flour samples was determined by investigating the surface morphology, various chemical elements, molecular bonds and structures, and optical properties. EDX characterization showed that carbon (C) and oxygen (O) content increased while potassium (K) content de-creased significantly in samples purified using centrifugation and soaking methods. In addition, the FTIR spectrum confirmed the existence of H₂O functional group peaks, which explains the presence of potassium oxalate monohydrate in porang flour samples without purification and after soaking for 30 minutes and 7 days, respectively. According to the ¹HNMR results, the centrifugation purification method on porang flour significantly reduces the oxalate structure. The results of the ¹HNMR peak analysis showed that all samples contained Mannose and Glucose compounds such as α-D-Manose, β-D Mannose, α-D-glucose, β-D-Glucose, β-D-NAcetylmannosamine (β-D-ManNAc), α-D-NAcetylmannosamine (α-D-ManNAc), β-D-NAcetylglucosamine (β-D-GlcNAc) and α-D-NAcetylglucosamine (α-D-GlcNAc).The UV–Vis spectroscopy characteristics of the porang flour sample soaked for 7 days showed a lower absorption peak than the sample soaked for 30 minutes without purification. This shows that purification with a 7-day soaking method yields low oxalic acid levels, especially potassium oxalate monohydrate. As a result, purification by soaking for 7 days is an efficient method to produce porang flour with low potassium oxalate monohydrate levels. As a result, the purification method has the potential to be used in a variety of applications using porang flour, especially as a biomaterial in the medical field.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100659"},"PeriodicalIF":6.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}