Carbohydrate Polymer Technologies and Applications最新文献_第4页

Development of clay/alginate/chondroitin sulfate composite microspheres via continuous process for chronic wounds regeneration

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-13 DOI: 10.1016/j.carpta.2025.100711

Cristian Nomicisio , Marco Ruggeri , Christine Taviot-Guého , Cinzia Boselli , Antonia Icaro Cornaglia , Eleonora Bianchi , Elena Del Favero , Caterina Ricci , Giuseppe Firpo , Barbara Vigani , Paolo Vacca , César Viseras , Silvia Rossi , Giuseppina Sandri

Chronic wounds significantly affect the quality of life of millions of people, generating substantial problems for the patients and for health care systems. Therefore, this work focuses on the development of microparticles based on alginate and chondroitin sulfate which were doped with layered double hydroxides (LDH), anionic clay minerals, based on Zn and Al. The obtained clay/polysaccharide composite materials could provide enhanced properties for wound healing, in particular related to cell adhesion and proliferation. The microparticles were manufactured by spray drying and crosslinked using CaCl₂ to obtain insoluble scaffolds for application in the physiological environment. The materials and the process were chosen continuous manufacturing in the industrial field. The mean diameter of the obtained microparticles ranged from 10 to 15 µm with a narrow dimensional distribution. Solid state characterizations (XRD, FTIR, SAXS, TGA/DSC) confirmed the LDH doping in a concentration of around 5 %w/w. The presence of LDH enhanced the stability of the systems in aqueous environment, increasing the wettability and decreasing the zeta potential due to their positive charge. Preclinical in vitro studies suggested a positive impact of LDH doping which led to a cell proliferation increase of around 15 %. In vivo studies demonstrated the safety and efficacy of the systems, suggesting the potential of this platform for therapeutic use.

{"title":"Development of clay/alginate/chondroitin sulfate composite microspheres via continuous process for chronic wounds regeneration","authors":"Cristian Nomicisio , Marco Ruggeri , Christine Taviot-Guého , Cinzia Boselli , Antonia Icaro Cornaglia , Eleonora Bianchi , Elena Del Favero , Caterina Ricci , Giuseppe Firpo , Barbara Vigani , Paolo Vacca , César Viseras , Silvia Rossi , Giuseppina Sandri","doi":"10.1016/j.carpta.2025.100711","DOIUrl":"10.1016/j.carpta.2025.100711","url":null,"abstract":"<div><div>Chronic wounds significantly affect the quality of life of millions of people, generating substantial problems for the patients and for health care systems. Therefore, this work focuses on the development of microparticles based on alginate and chondroitin sulfate which were doped with layered double hydroxides (LDH), anionic clay minerals, based on Zn and Al. The obtained clay/polysaccharide composite materials could provide enhanced properties for wound healing, in particular related to cell adhesion and proliferation. The microparticles were manufactured by spray drying and crosslinked using CaCl<sub>2</sub> to obtain insoluble scaffolds for application in the physiological environment. The materials and the process were chosen continuous manufacturing in the industrial field. The mean diameter of the obtained microparticles ranged from 10 to 15 µm with a narrow dimensional distribution. Solid state characterizations (XRD, FTIR, SAXS, TGA/DSC) confirmed the LDH doping in a concentration of around 5 %w/w. The presence of LDH enhanced the stability of the systems in aqueous environment, increasing the wettability and decreasing the zeta potential due to their positive charge. Preclinical in vitro studies suggested a positive impact of LDH doping which led to a cell proliferation increase of around 15 %. In vivo studies demonstrated the safety and efficacy of the systems, suggesting the potential of this platform for therapeutic use.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 ","pages":"Article 100711"},"PeriodicalIF":6.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pectin from fruit peel: A comprehensive review on various extraction approaches and their potential applications in pharmaceutical and food industries

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-11 DOI: 10.1016/j.carpta.2025.100708

Snigdha Satabdi Dixit , L. Muruganandam , I. Ganesh Moorthy

The complex heteropolysaccharide pectin has become a versatile biological polymer with possible applications in the pharmaceutical and food industries. Pectin has a lot of potential applications in cancer treatment as well. Pectin is an underutilized resource that is abundant and renewable. Understanding pectin's physicochemical qualities and functional features necessitates an awareness of its structural characterization, which includes metrics such as degree of esterification, molecular weight, and functional groups. This study thoroughly investigates the process of removing pectin from fruit peels, purifying, and characterizing. The effectiveness of extraction processes, including established and novel approaches, is evaluated closely to determine how they affect pectin production and quality. The detailed discussion includes further purifying procedures to eliminate impurities and improve pectin characteristics. This study addresses the practical applications of pectin as a texturizing agent in the food sector and its possible effectiveness in the pharmaceutical industry as a bioactive molecule and drug delivery carrier. To promote the creation of sustainable and high-value pectin-based products, difficulties related to pectin extraction, purification, and characterization are noted, along with possible directions for further study.

{"title":"Pectin from fruit peel: A comprehensive review on various extraction approaches and their potential applications in pharmaceutical and food industries","authors":"Snigdha Satabdi Dixit , L. Muruganandam , I. Ganesh Moorthy","doi":"10.1016/j.carpta.2025.100708","DOIUrl":"10.1016/j.carpta.2025.100708","url":null,"abstract":"<div><div>The complex heteropolysaccharide pectin has become a versatile biological polymer with possible applications in the pharmaceutical and food industries. Pectin has a lot of potential applications in cancer treatment as well. Pectin is an underutilized resource that is abundant and renewable. Understanding pectin's physicochemical qualities and functional features necessitates an awareness of its structural characterization, which includes metrics such as degree of esterification, molecular weight, and functional groups. This study thoroughly investigates the process of removing pectin from fruit peels, purifying, and characterizing. The effectiveness of extraction processes, including established and novel approaches, is evaluated closely to determine how they affect pectin production and quality. The detailed discussion includes further purifying procedures to eliminate impurities and improve pectin characteristics. This study addresses the practical applications of pectin as a texturizing agent in the food sector and its possible effectiveness in the pharmaceutical industry as a bioactive molecule and drug delivery carrier. To promote the creation of sustainable and high-value pectin-based products, difficulties related to pectin extraction, purification, and characterization are noted, along with possible directions for further study.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100708"},"PeriodicalIF":6.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in characterization and preclinical applications of hyaluronic acid-based biomaterials for wound healing: A review

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-10 DOI: 10.1016/j.carpta.2025.100706

Marjan Talebi , Rouzbeh Almasi Ghale , Roghayeh Mokhtari Asl , Fatemeh Tabandeh

Wound healing involves replacing damaged tissue with new, healthy tissue. While conventional dressings are used, more effective solutions are needed, especially for chronic wounds. This review offers a comprehensive update on newly developed hyaluronic acid-based biomaterials used in the wound healing process focusing on preclinical aspects. Biomaterials play a pivotal role in modern wound healing applications, with hyaluronic acid (HA) emerging as a promising component in advanced dressing technologies. HA, a glycosaminoglycan, is crucial for inflammatory responses, angiogenesis, and tissue regeneration. We discuss how molecular weight, concentration, and chemical modifications affect the properties of HA-based dressings. Additionally, we explore the potential of combining HA with other biomaterials and the development of sustained release systems. The biocompatibility, biodegradability, and hydrophilic properties of HA facilitate its incorporation into various wound dressing materials such as sponges, hydrogels, films, and electrospun membranes. Notably, HA-based hydrogel dressings can be used throughout all four stages of wound healing. This study highlights the roles of natural and synthetic biomaterials in wound dressings, and the potential applications of HA in treating infection, diabetic wounds, burns, and pain management. Furthermore, clinical prospects for wound healing with HA are elaborated upon.

{"title":"Advancements in characterization and preclinical applications of hyaluronic acid-based biomaterials for wound healing: A review","authors":"Marjan Talebi , Rouzbeh Almasi Ghale , Roghayeh Mokhtari Asl , Fatemeh Tabandeh","doi":"10.1016/j.carpta.2025.100706","DOIUrl":"10.1016/j.carpta.2025.100706","url":null,"abstract":"<div><div>Wound healing involves replacing damaged tissue with new, healthy tissue. While conventional dressings are used, more effective solutions are needed, especially for chronic wounds. This review offers a comprehensive update on newly developed hyaluronic acid-based biomaterials used in the wound healing process focusing on preclinical aspects. Biomaterials play a pivotal role in modern wound healing applications, with hyaluronic acid (HA) emerging as a promising component in advanced dressing technologies. HA, a glycosaminoglycan, is crucial for inflammatory responses, angiogenesis, and tissue regeneration. We discuss how molecular weight, concentration, and chemical modifications affect the properties of HA-based dressings. Additionally, we explore the potential of combining HA with other biomaterials and the development of sustained release systems. The biocompatibility, biodegradability, and hydrophilic properties of HA facilitate its incorporation into various wound dressing materials such as sponges, hydrogels, films, and electrospun membranes. Notably, HA-based hydrogel dressings can be used throughout all four stages of wound healing. This study highlights the roles of natural and synthetic biomaterials in wound dressings, and the potential applications of HA in treating infection, diabetic wounds, burns, and pain management. Furthermore, clinical prospects for wound healing with HA are elaborated upon.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100706"},"PeriodicalIF":6.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-08 DOI: 10.1016/j.carpta.2025.100691

Liangliang Hu , Ting Meng , Davies Marabada , Zhichao Jin , Qing Huang , Shijie Wei , Zhizhong Wang

5-Fluorouracil (5-FU) serves as a first-line therapeutic agent for colorectal cancer, however, its utility is limited by a short half-life and significant cytotoxicity. This study focused on the construction of 5-Fluorouracil-β-Cyclodextrin polymers (5-FUSA-β-CD and 5-FUBA-β-CD) by covalent conjugation using linker strategies to address limitations. The cytotoxicity assays on human colon cancer cell lines HT-29 and normal colon epithelial cells NCM-460 demonstrated that the IC₅₀ value of the 5-FUBA-β-CD conjugate for the HT-29 cells was 38.72 ± 0.13 μM, indicating superior antitumor activity compared to both 5-FUBA-β-CD and 5-FU. Additionally, the conjugate exhibited reduced cytotoxicity towards normal colon epithelial cells. Pharmacokinetic analyses revealed that 5-FUSA-β-CD and 5-FUBA-β-CD were eliminated slowly and their half-lives were longer than that of free 5-FU. Distinct linkers were meticulously designed and synthesized to generate 5-Fluorouracil-β-Cyclodextrin conjugates that exhibit differential anti-colon cancer activity and half-lives. These findings not only demonstrated that 5-Fluorouracil-β-Cyclodextrin conjugates exhibits superior antitumor activity and reduced toxicity but also suggest that the linker plays a crucial role in determining both the efficacy of drug conjugates as an anticancer agent and its associated adverse effects. Future designs of linker can be optimized for greater efficiency.

{"title":"5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects","authors":"Liangliang Hu , Ting Meng , Davies Marabada , Zhichao Jin , Qing Huang , Shijie Wei , Zhizhong Wang","doi":"10.1016/j.carpta.2025.100691","DOIUrl":"10.1016/j.carpta.2025.100691","url":null,"abstract":"<div><div>5-Fluorouracil (5-FU) serves as a first-line therapeutic agent for colorectal cancer, however, its utility is limited by a short half-life and significant cytotoxicity. This study focused on the construction of 5-Fluorouracil-β-Cyclodextrin polymers (5-FUSA-β-CD and 5-FUBA-β-CD) by covalent conjugation using linker strategies to address limitations. The cytotoxicity assays on human colon cancer cell lines HT-29 and normal colon epithelial cells NCM-460 demonstrated that the IC<sub>50</sub> value of the 5-FUBA-β-CD conjugate for the HT-29 cells was 38.72 ± 0.13 μM, indicating superior antitumor activity compared to both 5-FUBA-β-CD and 5-FU. Additionally, the conjugate exhibited reduced cytotoxicity towards normal colon epithelial cells. Pharmacokinetic analyses revealed that 5-FUSA-β-CD and 5-FUBA-β-CD were eliminated slowly and their half-lives were longer than that of free 5-FU. Distinct linkers were meticulously designed and synthesized to generate 5-Fluorouracil-β-Cyclodextrin conjugates that exhibit differential anti-colon cancer activity and half-lives. These findings not only demonstrated that 5-Fluorouracil-β-Cyclodextrin conjugates exhibits superior antitumor activity and reduced toxicity but also suggest that the linker plays a crucial role in determining both the efficacy of drug conjugates as an anticancer agent and its associated adverse effects. Future designs of linker can be optimized for greater efficiency.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100691"},"PeriodicalIF":6.2,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amine modified sodium alginate: Synthesis, characterization and in vivo evaluation in rainbow trout (Oncorhynchus mykiss)

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-06 DOI: 10.1016/j.carpta.2025.100699

Samira Salarvand , Seyed Amir Hossein Jalali , Nasrollah Mahboobi Soofiani , Alireza Allafchian

Alginate is a natural linear anionic biopolymer abundantly found in the seabed. Alginate becomes an adequate option as a diet improver or drug/gene carrier through chemical modification processes and changes in its structure. This study modified a simple sodium alginate by oxidation and reductive amination processes. The characteristics of modified sodium alginate were evaluated by FTIR, XRD, zeta potential, FE-SEM, EDX, and MAP analysis. Its cytotoxicity was evaluated using an MTT assay. Finally, its effects were assessed orally in rainbow trout (3 ± 0.3 g) for 6 weeks at 2 levels (2.5 and 5 g kg^-1). The characterization showed that the chemical modification process was successful, and amine groups were incorporated into the alginate structure. The amount of amine added to modified sodium alginate was 2.53 % based on EDX. MTT results showed no cytotoxicity for modified alginate. The in vivo results showed that amine-modified alginate treatments significantly increased non-specific immune parameters, including lysozyme activity, alternative complement activity, and serum bactericidal activity, and also enhanced intestinal bacterial population compared with the control and simple alginate treatments (P < 0.05). Administration of 2.5 and 5 g kg^-1 modified alginate significantly increased FCR (0.84±0.01 and 0.83±0.04, respectively) and other growth parameters compared with other experimental groups (P < 0.05). Also, after being challenged by ozone, amine-modified alginate fish groups showed the highest relative percent survival (RPS) values (75 %, 90 %). This improvement can be attributed to the modified alginate's nature and the amine groups' role in its structure. Therefore, amine-modified alginate can be suggested as an immunostimulant.

{"title":"Amine modified sodium alginate: Synthesis, characterization and in vivo evaluation in rainbow trout (Oncorhynchus mykiss)","authors":"Samira Salarvand , Seyed Amir Hossein Jalali , Nasrollah Mahboobi Soofiani , Alireza Allafchian","doi":"10.1016/j.carpta.2025.100699","DOIUrl":"10.1016/j.carpta.2025.100699","url":null,"abstract":"<div><div>Alginate is a natural linear anionic biopolymer abundantly found in the seabed. Alginate becomes an adequate option as a diet improver or drug/gene carrier through chemical modification processes and changes in its structure. This study modified a simple sodium alginate by oxidation and reductive amination processes. The characteristics of modified sodium alginate were evaluated by FTIR, XRD, zeta potential, FE-SEM, EDX, and MAP analysis. Its cytotoxicity was evaluated using an MTT assay. Finally, its effects were assessed orally in rainbow trout (3 ± 0.3 g) for 6 weeks at 2 levels (2.5 and 5 g kg<sup>-1</sup>). The characterization showed that the chemical modification process was successful, and amine groups were incorporated into the alginate structure. The amount of amine added to modified sodium alginate was 2.53 % based on EDX. MTT results showed no cytotoxicity for modified alginate. The <em>in vivo</em> results showed that amine-modified alginate treatments significantly increased non-specific immune parameters, including lysozyme activity, alternative complement activity, and serum bactericidal activity, and also enhanced intestinal bacterial population compared with the control and simple alginate treatments (<em>P</em> < 0.05). Administration of 2.5 and 5 g kg<sup>-1</sup> modified alginate significantly increased FCR (0.84±0.01 and 0.83±0.04, respectively) and other growth parameters compared with other experimental groups (<em>P</em> < 0.05). Also, after being challenged by ozone, amine-modified alginate fish groups showed the highest relative percent survival (RPS) values (75 %, 90 %). This improvement can be attributed to the modified alginate's nature and the amine groups' role in its structure. Therefore, amine-modified alginate can be suggested as an immunostimulant.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100699"},"PeriodicalIF":6.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143351141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yogurt enrichment with sulfated alginate microcapsules containing garlic- and cardamom essential oils-loaded β-cyclodextrin: Investigating physicochemical and biological properties

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-05 DOI: 10.1016/j.carpta.2025.100694

Marjan Teymuri-Yeghaneh , Davoud Salarbashi , Hossein Derakhshankhah , Mehdi Jaymand

Side effects of synthetic food additives caused considerable concerns. In this context, natural substances such as essential oils (EOs) have received significant interest owing to their safety as well as anti-oxidant, anti-microbial, anti-cancer, anti-inflammatory, hypoglycemic, and some other biological properties. The purpose of this study was to use natural preservatives to determine the effect of sulfated alginate (S-Alg) microcapsules contaning cardamom (CEO)- and garlic (GEO) essential oils-loaded β-cyclodextrin (β-CD) on pathogenic and spoilage bacteria as well as anti-oxidant properties to increase shelf-life in yogurt. For this purpose, CEO and GEO were loaded into β-CD, and then encapsulated into S-Alg microparticles. The microcapsules containing CEO- and GEO-loaded β-CD were added to milk at three different concentrations (0.5, 1, and 1.5 % w/v) to prepare yogurt, and then anti-oxidant, pH, syneresis, sensory, and anti-bacterial properties of the resultant yogurt were evaluated during 21 days of storage. It was found that adding encapsulated CEO and GEO increased the shelf-life of yogurt and preserved its sensory and anti-bacterial properties during 21 days of storage compared to pure EOs.

{"title":"Yogurt enrichment with sulfated alginate microcapsules containing garlic- and cardamom essential oils-loaded β-cyclodextrin: Investigating physicochemical and biological properties","authors":"Marjan Teymuri-Yeghaneh , Davoud Salarbashi , Hossein Derakhshankhah , Mehdi Jaymand","doi":"10.1016/j.carpta.2025.100694","DOIUrl":"10.1016/j.carpta.2025.100694","url":null,"abstract":"<div><div>Side effects of synthetic food additives caused considerable concerns. In this context, natural substances such as essential oils (EOs) have received significant interest owing to their safety as well as anti-oxidant, anti-microbial, anti-cancer, anti-inflammatory, hypoglycemic, and some other biological properties. The purpose of this study was to use natural preservatives to determine the effect of sulfated alginate (S-Alg) microcapsules contaning cardamom (CEO)- and garlic (GEO) essential oils-loaded β-cyclodextrin (β-CD) on pathogenic and spoilage bacteria as well as anti-oxidant properties to increase shelf-life in yogurt. For this purpose, CEO and GEO were loaded into β-CD, and then encapsulated into S-Alg microparticles. The microcapsules containing CEO- and GEO-loaded β-CD were added to milk at three different concentrations (0.5, 1, and 1.5 % w/v) to prepare yogurt, and then anti-oxidant, pH, syneresis, sensory, and anti-bacterial properties of the resultant yogurt were evaluated during 21 days of storage. It was found that adding encapsulated CEO and GEO increased the shelf-life of yogurt and preserved its sensory and anti-bacterial properties during 21 days of storage compared to pure EOs.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100694"},"PeriodicalIF":6.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chito-oligosaccharides (COS) with anti-aging effect from Flammulina velutipes

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-05 DOI: 10.1016/j.carpta.2025.100705

Qian Teng, Peng Wang, Fei Fang, Qinghong Liu

Chito-oligosaccharides (COS) with a degree of deacetylation (DD) of 67.85 % and a degree of polymerization (DP) ranging from 2 to 6 was prepared from Flammulina velutipes (F. velutipes). The COS was confirmed as α-form by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Nuclear magnetic resonance analysis (NMR). Furthermore, the in vitro antioxidant activity of COS was evaluated, along with its anti-aging effects in D-Galactose (D-gal)-induced aging BALB/c mice. COS treatment demonstrated a dose-dependent enhancement in the scavenging activities of DPPH, ABTS, and hydroxyl radicals. Additionally, COS treatment alleviated tissue injury in the liver and kidney of mice induced by D-gal. The antioxidative indices, including superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px), were improved in the liver of mice treated with COS. Moreover, the relative expressions of inflammatory factors Interleukin-1β (IL-1β) and Interleukin-6 (IL-6) were reduced in the COS treatment groups. These findings indicate that F. velutipes COS exhibits resistance to D-gal-induced aging, with mechanisms linked to its antioxidant and immunoregulatory activities. This suggests that F. velutipes COS may serve as a potential source of antioxidant and anti-aging agent.

{"title":"Chito-oligosaccharides (COS) with anti-aging effect from Flammulina velutipes","authors":"Qian Teng, Peng Wang, Fei Fang, Qinghong Liu","doi":"10.1016/j.carpta.2025.100705","DOIUrl":"10.1016/j.carpta.2025.100705","url":null,"abstract":"<div><div>Chito-oligosaccharides (COS) with a degree of deacetylation (DD) of 67.85 % and a degree of polymerization (DP) ranging from 2 to 6 was prepared from <em>Flammulina velutipes</em> (<em>F. velutipes</em>). The COS was confirmed as α-form by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Nuclear magnetic resonance analysis (NMR). Furthermore, the <em>in vitro</em> antioxidant activity of COS was evaluated, along with its anti-aging effects in D-Galactose (D-gal)-induced aging BALB/c mice. COS treatment demonstrated a dose-dependent enhancement in the scavenging activities of DPPH, ABTS, and hydroxyl radicals. Additionally, COS treatment alleviated tissue injury in the liver and kidney of mice induced by D-gal. The antioxidative indices, including superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px), were improved in the liver of mice treated with COS. Moreover, the relative expressions of inflammatory factors Interleukin-1β (IL-1β) and Interleukin-6 (IL-6) were reduced in the COS treatment groups. These findings indicate that <em>F. velutipes</em> COS exhibits resistance to D-gal-induced aging, with mechanisms linked to its antioxidant and immunoregulatory activities. This suggests that <em>F. velutipes</em> COS may serve as a potential source of antioxidant and anti-aging agent.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100705"},"PeriodicalIF":6.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning-assisted sedimentation analysis of cellulose nanofibers to predict the specific surface area

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-04 DOI: 10.1016/j.carpta.2025.100697

Koyuru Nakayama, Akio Kumagai, Keita Sakakibara

This study introduced a novel machine learning (ML) approach for predicting the specific surface area (SSA) of cellulose nanofibers (CNFs) at various fibrillation stages by leveraging sedimentation profiles from their aqueous slurries. Both sedimentation speed and sedimentation heatmap images, derived from the sedimentation profile data, formed the basis of the ML-assisted prediction model, achieving a coefficient of determination (R²) of up to 0.94 for SSA prediction. The high R² values can be obtained through the appropriate ML algorithms used for the prediction model, including extreme gradient-boosting (XGBoost) regression and convolutional neural networks (CNN) for sedimentation speed and sedimentation heatmap images, respectively, which are effective to deal with these sedimentation data, enabling accurate predictions. Furthermore, the predicted SSA values were used for the construction of the prediction model for impact strength of polypropylene/ wood-derived CNF composite materials by integrating with the infrared spectrum data of the CNFs, achieving the improved R² of 0.88, as compared to the conventional models based on experimentally obtained SSA with R² = 0.79. This sedimentation analysis method therefore enables the acquisition of information related to the morphology of CNFs, which can be widely applied in the quality control of CNFs as well as in the material applications.

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引用次数: 0

Conductive supramolecular acrylate hydrogels enabled by quaternized chitosan ionic crosslinking for high-fidelity 3D printing

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-04 DOI: 10.1016/j.carpta.2025.100702

Lukas A. Bauman, Boxin Zhao

While 3D printing has enabled the fabrication of hydrogels with complex structures, high fidelity techniques (vat polymerization) that enable precisely engineered design of hydrogels require stiff structures to withstand the forces of printing. This is a pressing research gap in hydrogel vat-polymerization 3D printing. To address this limitation, a novel ionic crosslinker consisting of quaternized chitosan complexed with 3-sulfopropyl acrylate was used to form supramolecular 2-hydroxyethyl acrylate organogel precursors. The Cyrene organogel enhanced mechanical properties enabling the printing of high-fidelity structures; the final compliant hydrogels were then obtained through solvent exchange with water. This yielded high-fidelity 3D-printed conductive supramolecular hydrogels with tensile properties of 288±29 kPa at 516±37 % elongation and compressive properties of 572±34 kPa at 65±4 % strain with uniform swelling (320–350 %). Nuclear magnetic resonance and conductivity measurements confirmed SPA-rich blocks within the hydrogel network and the solvent-dependent copolymer structure. Furthermore, through varying the anionic acrylate concentration, ultimate strain between 222 % and 516 % was achieved at a constant elastic modulus. Additionally, electrical properties were tunable with conductivity reaching 156 mS/m at 7 MH in ultrapure water. This work advances applications of quaternized chitosan as an ionic crosslinker in printable conductive hydrogels, opening new applications in medical and technological fields.

{"title":"Conductive supramolecular acrylate hydrogels enabled by quaternized chitosan ionic crosslinking for high-fidelity 3D printing","authors":"Lukas A. Bauman, Boxin Zhao","doi":"10.1016/j.carpta.2025.100702","DOIUrl":"10.1016/j.carpta.2025.100702","url":null,"abstract":"<div><div>While 3D printing has enabled the fabrication of hydrogels with complex structures, high fidelity techniques (vat polymerization) that enable precisely engineered design of hydrogels require stiff structures to withstand the forces of printing. This is a pressing research gap in hydrogel vat-polymerization 3D printing. To address this limitation, a novel ionic crosslinker consisting of quaternized chitosan complexed with 3-sulfopropyl acrylate was used to form supramolecular 2-hydroxyethyl acrylate organogel precursors. The Cyrene organogel enhanced mechanical properties enabling the printing of high-fidelity structures; the final compliant hydrogels were then obtained through solvent exchange with water. This yielded high-fidelity 3D-printed conductive supramolecular hydrogels with tensile properties of 288±29 kPa at 516±37 % elongation and compressive properties of 572±34 kPa at 65±4 % strain with uniform swelling (320–350 %). Nuclear magnetic resonance and conductivity measurements confirmed SPA-rich blocks within the hydrogel network and the solvent-dependent copolymer structure. Furthermore, through varying the anionic acrylate concentration, ultimate strain between 222 % and 516 % was achieved at a constant elastic modulus. Additionally, electrical properties were tunable with conductivity reaching 156 mS/m at 7 MH in ultrapure water. This work advances applications of quaternized chitosan as an ionic crosslinker in printable conductive hydrogels, opening new applications in medical and technological fields.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100702"},"PeriodicalIF":6.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable multi-purpose bacterial cellulose composite for food packaging via facile successive infiltration

IF 6.2 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymer Technologies and Applications

Pub Date : 2025-02-04 DOI: 10.1016/j.carpta.2025.100703

I-Tseng Liu, Cheng-Ying Li, Ying-Chih Liao

Petroleum-based plastic packaging materials have been widely used, causing severe environmental impacts. To address this challenge, there is an urgent need to develop biodegradable materials that offer strong mechanical and excellent barrier properties while ensuring food safety. In this study, sustainable, high-performance film derived from bacterial cellulose (BC) through a straightforward and eco-friendly water-based successive infiltration process is developed. To enhance the transparency and haze of BC specimens for better visual detection, waterborne polyurethane (WPU) is infiltrated for refractive index compensation and serves as an adhesive. Subsequently, the mechanical strength and water resistance of the BC/WPU films are improved by incorporating a seaweed extract, sodium alginate (SA), and metal ion chelation (Ca²⁺, Al³⁺, and Zr⁴⁺). The resulting BC/WPU/[email protected] film exhibited low hygroscopicity (+53.5 % after 190 h of immersion), high transparency (90.01 %) and excellent haze (10.91 %), exceptional tensile strength (82.8 MPa) and modulus (6.96 GPa), low gas permeability (OP = 0.0137 mL-mm/m²-day-atm and WVP = 8.75 g-mm/m²-day-atm), high biodegradability (85.23 % weight loss in 49 days), high flexibility, formability, and great heat sealability. These outstanding features make the BC/WPU/[email protected] film exceptionally well-suited for advanced and versatile packaging applications. Several examples were also demonstrated to show its exceptional potential for packaging applications.

{"title":"Sustainable multi-purpose bacterial cellulose composite for food packaging via facile successive infiltration","authors":"I-Tseng Liu, Cheng-Ying Li, Ying-Chih Liao","doi":"10.1016/j.carpta.2025.100703","DOIUrl":"10.1016/j.carpta.2025.100703","url":null,"abstract":"<div><div>Petroleum-based plastic packaging materials have been widely used, causing severe environmental impacts. To address this challenge, there is an urgent need to develop biodegradable materials that offer strong mechanical and excellent barrier properties while ensuring food safety. In this study, sustainable, high-performance film derived from bacterial cellulose (BC) through a straightforward and eco-friendly water-based successive infiltration process is developed. To enhance the transparency and haze of BC specimens for better visual detection, waterborne polyurethane (WPU) is infiltrated for refractive index compensation and serves as an adhesive. Subsequently, the mechanical strength and water resistance of the BC/WPU films are improved by incorporating a seaweed extract, sodium alginate (SA), and metal ion chelation (Ca<sup>2+</sup>, Al<sup>3+</sup>, and Zr<sup>4+</sup>). The resulting BC/WPU/[email protected] film exhibited low hygroscopicity (+53.5 % after 190 h of immersion), high transparency (90.01 %) and excellent haze (10.91 %), exceptional tensile strength (82.8 MPa) and modulus (6.96 GPa), low gas permeability (OP = 0.0137 mL-mm/m²-day-atm and WVP = 8.75 g-mm/m²-day-atm), high biodegradability (85.23 % weight loss in 49 days), high flexibility, formability, and great heat sealability. These outstanding features make the BC/WPU/[email protected] film exceptionally well-suited for advanced and versatile packaging applications. Several examples were also demonstrated to show its exceptional potential for packaging applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"9 ","pages":"Article 100703"},"PeriodicalIF":6.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0