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Recent Advancements and Future Prospects in NBD-Based Fluorescent Chemosensors: Design Strategy, Sensing Mechanism, and Biological Applications 基于 NBD 的荧光化学传感器的最新进展和未来展望:设计策略、传感机制和生物应用
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-04-09 DOI: 10.1080/10408347.2024.2337869
Gurdeep Kaur, Richa Rani, Jeevika Raina, Iqubal Singh
In recent years, the field of Supramolecular Chemistry has witnessed tremendous progress owing to the development of versatile optical sensors for the detection of harmful biological analytes. Nitr...
近年来,由于用于检测有害生物分析物的多功能光学传感器的开发,超分子化学领域取得了巨大进步。硝...
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引用次数: 0
Exploring the Living Cell: Applications and Advances of Scanning Electrochemical Microscopy. 探索活细胞:扫描电化学显微镜的应用与进展》。
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-04-01 DOI: 10.1080/10408347.2024.2328135
Margarita Poderyte, Arunas Ramanavicius, Aušra Valiūnienė

A living cell is a complex network of molecular, biochemical and physiological processes. Cellular activities, such as ion transport, metabolic processes, and cell-cell interactions can be determined electrochemically by detecting the electrons or ions exchanged in these processes. Electrochemical methods often are noninvasive, and they can enable the real-time monitoring of cellular processes. Scanning electrochemical microscopy (SECM) is an advanced scanning probe electroanalysis technique that can map the surface topography and local reactivity of a substrate with high precision at the micro- or nanoscale. By measuring electrochemical signals, such as redox reactions, ion fluxes, and pH changes, SECM can provide valuable insights into cellular activity. As a result of its compatibility with liquid medium measurements and its nondestructive nature, SECM has gained popularity in living cell research. This review aims to furnish an overview of SECM, elucidating its principles, applications, and its potential to contribute significantly to advancements in cell biology, electroporation, and biosensors. As a multidisciplinary tool, SECM is distinguished by its ability to unravel the intricacies of living cells and offers promising avenues for breakthroughs in our understanding of cellular complexity.

活细胞是一个复杂的分子、生化和生理过程网络。通过检测这些过程中交换的电子或离子,可以用电化学方法确定细胞活动,如离子转运、新陈代谢过程和细胞间相互作用。电化学方法通常是非侵入性的,可以对细胞过程进行实时监测。扫描电化学显微镜(SECM)是一种先进的扫描探针电分析技术,可在微米或纳米尺度上高精度地绘制基底的表面形貌和局部反应性。通过测量氧化还原反应、离子通量和 pH 值变化等电化学信号,SECM 可以提供有关细胞活动的宝贵信息。由于其与液体介质测量的兼容性和无损性,SECM 在活细胞研究中越来越受欢迎。本综述旨在概述 SECM,阐明其原理、应用及其在推动细胞生物学、电穿孔和生物传感器方面的潜力。作为一种多学科工具,SECM 的独特之处在于它能够揭示活细胞的复杂性,并为我们突破对细胞复杂性的理解提供了一条充满希望的途径。
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引用次数: 0
Recent Advances on Metal Oxide Based Sensors for Environmental Gas Pollutants Detection 基于金属氧化物的环境气体污染物检测传感器的最新进展
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-03-20 DOI: 10.1080/10408347.2024.2325129
Sofian Kanan, Khaled Obeideen, Matthew Moyet, Heba Abed, Danyah Khan, Aysha Shabnam, Yehya El-Sayed, Mahreen Arooj, Ahmed A Mohamed
Optimizing materials and associated structures for detecting various environmental gas pollutant concentrations has been a major challenge in environmental sensing technology. Semiconducting metal ...
优化用于检测各种环境气体污染物浓度的材料和相关结构一直是环境传感技术的一大挑战。半导体金属...
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引用次数: 0
Advances in Fluorescent Nanosensors for Detection of Vitamin B12. 用于检测维生素 B12 的荧光纳米传感器的进展。
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-03-18 DOI: 10.1080/10408347.2024.2328104
Yongming Guo, Yijin Li, Yubin Xiang

Vitamin B12 plays a significant role in maintaining human health. Deficiency or excess intake of vitamin B12 may cause some diseases. Therefore, it is significant to fabricate sensors for sensitive assay of vitamin B12. In the past few years, a variety of nanomaterials have been developed for the fluorescence detection of vitamin B12 in tablets, injection, human serum and food. In the review, the assay mechanisms of fluorescent nanomaterials for sensing vitamin B12 were first briefly discussed. And the progress of various nanomaterials for fluorescence detection of vitamin B12 were systematically summarized. Furthermore, the sensing performance of fluorescent nanosensors was compared with fluorescent probes. Lastly, the challenges and perspectives about the topic were presented.

维生素 B12 在维护人类健康方面发挥着重要作用。缺乏或过量摄入维生素 B12 可能会导致某些疾病。因此,制造灵敏检测维生素 B12 的传感器意义重大。在过去几年中,已经开发出多种纳米材料,用于片剂、注射剂、人体血清和食品中维生素 B12 的荧光检测。在综述中,首先简要讨论了荧光纳米材料检测维生素 B12 的机理。并系统总结了各种纳米材料在荧光检测维生素 B12 方面的研究进展。此外,还比较了荧光纳米传感器与荧光探针的传感性能。最后,提出了有关该主题的挑战和展望。
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引用次数: 0
Protecting the Last Line of Defense: Analytical Approaches for Sample Preparation and Determination of the Reserve Group of Antibiotics in the Environment. 保护最后一道防线:样品制备和环境中储备类抗生素测定的分析方法。
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-03-17 DOI: 10.1080/10408347.2024.2321161
Joanna Wilk, Sylwia Bajkacz

Drug resistance in microorganisms is a serious threat to life and health due to the limited number of antibiotics that show efficacy in treating infections and the difficulty in discovering new compounds with antibacterial activity. To address this issue, the World Health Organization created the AWaRe classification, a tool to support global and national antimicrobial stewardship programs. The AWaRe list categorizes antimicrobials into three groups - Access, Watch, and Reserve - according to their intended use. The Reserve group comprises "last resort" medicines used solely for treating infections caused by bacterial strains that are resistant to other treatments. It is therefore necessary to protect them, not only by using them as prudently as possible in humans and animals, but also by monitoring their subsequent fate. Unmetabolized antibiotics enter the environment through hospital and municipal wastewater or from manure, subsequently contaminating bodies of water and soils, thus contributing to the emergence and spread of antibiotic resistance. This article presents a review of determination methods for the Reserve group of antimicrobials in water, wastewater, and manure. Procedures for extracting and determining these substances in environmental samples are described, showing the limited research available, which is typically on a local level.

由于能有效治疗感染的抗生素数量有限,而且很难发现具有抗菌活性的新化合物,微生物的耐药性严重威胁着人们的生命和健康。为解决这一问题,世界卫生组织创建了 AWaRe 分类,作为支持全球和国家抗菌药物管理计划的工具。AWaRe 列表根据抗菌药物的预期用途将其分为三类:准入类、观察类和储备类。储备组包括 "最后手段 "药物,仅用于治疗对其他疗法产生抗药性的细菌菌株引起的感染。因此,有必要保护这些药物,不仅要尽可能谨慎地在人类和动物身上使用,还要监测它们随后的去向。未代谢的抗生素通过医院和市政废水或粪便进入环境,随后污染水体和土壤,从而导致抗生素耐药性的出现和传播。本文综述了水、废水和粪便中 Reserve 类抗菌素的测定方法。文章介绍了在环境样本中提取和测定这些物质的程序,并展示了有限的研究成果,这些研究通常是在地方层面上进行的。
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引用次数: 0
MicroRNA Sensors Based on CRISPR/Cas12a Technologies: Evolution From Indirect to Direct Detection. 基于 CRISPR/Cas12a 技术的 MicroRNA 传感器:从间接检测到直接检测的演变。
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-03-15 DOI: 10.1080/10408347.2024.2329229
Songcheng Yu, Xueying Lei, Chenling Qu

MicroRNA (miRNA) has emerged as a promising biomarker for disease diagnosis and a potential therapeutic targets for drug development. The detection of miRNA can serve as a noninvasive tool in diseases diagnosis and predicting diseases prognosis. CRISPR/Cas12a system has great potential in nucleic acid detection due to its high sensitivity and specificity, which has been developed to be a versatile tool for nucleic acid-based detection of targets in various fields. However, conversion from RNA to DNA with or without amplification operation is necessary for miRNA detection based on CRISPR/Cas12a system, because dsDNA containing PAM sequence or ssDNA is traditionally considered as the activator of Cas12a. Until recently, direct detection of miRNA by CRISPR/Cas12a system has been reported. In this review, we provide an overview of the evolution of biosensors based on CRISPR/Cas12a for miRNA detection from indirect to direct, which would be beneficial to the development of CRISPR/Cas12a-based sensors with better performance for direct detection of miRNA.

微小核糖核酸(miRNA)已成为一种有前途的疾病诊断生物标志物和药物开发的潜在治疗靶点。检测 miRNA 可作为疾病诊断和预测疾病预后的非侵入性工具。CRISPR/Cas12a 系统因其高灵敏度和特异性,在核酸检测方面具有巨大潜力,已被开发为基于核酸检测各领域靶标的多功能工具。然而,基于CRISPR/Cas12a系统的miRNA检测必须经过或不经过扩增操作将RNA转化为DNA,因为含有PAM序列的dsDNA或ssDNA传统上被认为是Cas12a的激活剂。直到最近,才有通过 CRISPR/Cas12a 系统直接检测 miRNA 的报道。在这篇综述中,我们概述了基于 CRISPR/Cas12a 检测 miRNA 的生物传感器从间接到直接的演变过程,这将有利于开发性能更好的基于 CRISPR/Cas12a 的直接检测 miRNA 的传感器。
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引用次数: 0
Advances and Challenges in the Analysis of Boswellic Acids by Separation Methods. 采用分离方法分析乳香酸的进展与挑战。
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-03-10 DOI: 10.1080/10408347.2024.2312502
Dmytro Kosolapov, Pavel Jáč, Petra Riasová, Jitka Poušková, Miroslav Polášek, Lucie Nováková

Boswellia resin is an exudate from the cut bark of Boswellia trees. The main constituents of pharmacological interest are boswellic acids (pentacyclic triterpenoids), namely α-boswellic acid, β-boswellic acid, 3-O-acetyl-α-boswellic acid, 3-O-acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-β-boswellic acid. Nowadays, dietary supplements with Boswellia serrata extract are used in the treatment of inflammatory joint diseases. Additionally, the constituents of Boswellia resin have shown potential for the treatment of other chronic inflammatory diseases and various types of cancer. Separation methods including ultra/high-performance liquid chromatography, gas chromatography, thin layer chromatography, supercritical fluid chromatography, and capillary electrochromatography coupled with UV or MS detection have been used for the determination of boswellic acids in various matrices (mostly plant material and biological samples). This review aims to provide a comprehensive summary of these separation methods, offering a critical discussion of their strengths and limitations in the analysis of boswellic acids. The knowledge of various separation methods plays a pivotal role in the quality control of herbal dietary supplements and the monitoring of the metabolism and pharmacokinetics of their constituents. The approaches based on metabolomics and network pharmacology represent new ways of fingerprinting secondary metabolites in Boswellia resin increasing the comprehensiveness of the output of these methods resulting in safer dietary supplements.

乳香树脂是乳香树树皮切口的渗出物。具有药理作用的主要成分是乳香酸(五环三萜类化合物),即α-乳香酸、β-乳香酸、3-O-乙酰基-α-乳香酸、3-O-乙酰基-β-乳香酸、11-酮-β-乳香酸和 3-O-乙酰基-11-酮-β-乳香酸。如今,含有乳香提取物的膳食补充剂被用于治疗关节炎症。此外,乳香树脂的成分也显示出治疗其他慢性炎症疾病和各种癌症的潜力。超/高效液相色谱法、气相色谱法、薄层色谱法、超临界流体色谱法和毛细管电色谱法等分离方法已被用于测定各种基质(主要是植物材料和生物样品)中的乳香酸。本综述旨在对这些分离方法进行全面总结,并对其在乳香酸分析中的优势和局限性进行深入探讨。对各种分离方法的了解在中草药膳食补充剂的质量控制及其成分代谢和药代动力学监测中起着举足轻重的作用。基于代谢组学和网络药理学的方法代表了对乳香树脂中次生代谢物进行指纹识别的新方法,提高了这些方法产出的全面性,从而生产出更安全的膳食补充剂。
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引用次数: 0
The Role of Catecholamines in the Pathogenesis of Diseases and the Modified Electrodes for Electrochemical Detection of Catecholamines: A Review. 儿茶酚胺在疾病发病机制中的作用以及用于儿茶酚胺电化学检测的改良电极:综述。
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-03-10 DOI: 10.1080/10408347.2024.2324460
Meng Zhang, Yimeng Wang, Jie Jiang, Yanxiao Jiang, Daqian Song

Catecholamines (CAs), which include adrenaline, noradrenaline, and dopamine, are neurotransmitters and hormones that critically regulate the cardiovascular system, metabolism, and stress response in the human body. The abnormal levels of these molecules can lead to the development of various diseases, including pheochromocytoma and paragangliomas, Alzheimer's disease, and Takotsubo cardiomyopathy. Due to their low cost, high sensitivity, flexible detection strategies, ease of integration, and miniaturization, electrochemical techniques have been extensively employed in the detection of CAs, surpassing traditional analytical methods. Electrochemical detection of CAs in real samples is challenging due to the tendency of poisoning electrode. Chemically modified electrodes have been widely used to solve the problems of poor sensitivity and selectivity faced by bare electrodes. There are a few articles that provide an overview of electrochemical detection and efficient enrichment of CAs, but there is a dearth of updates on the role of CAs in the pathogenesis of diseases. Additionally, there is still a lack of systematic synthesis with a focus on modified electrodes for electrochemical detection. Thus, this review provides a summary of the recent clinical pathogenesis of CAs and the modified electrodes for electrochemical detection of CAs published between 2017 and 2022. Moreover, challenges and future perspectives are also highlighted. This work is expected to provide useful guidance to researchers entering this interdisciplinary field, promoting further development of CAs pathogenesis, and developing more novel chemically modified electrodes for the detection of CAs.

儿茶酚胺(CA)包括肾上腺素、去甲肾上腺素和多巴胺,是一种神经递质和激素,对人体的心血管系统、新陈代谢和应激反应具有重要调节作用。这些分子水平的异常会导致各种疾病的发生,包括嗜铬细胞瘤和副神经节瘤、阿尔茨海默病和塔克次氏心肌病。电化学技术具有成本低、灵敏度高、检测策略灵活、易于集成和微型化等优点,已被广泛应用于 CAs 的检测,并超越了传统的分析方法。由于电极容易中毒,在实际样品中对 CAs 进行电化学检测具有挑战性。为了解决裸电极灵敏度和选择性差的问题,化学修饰电极得到了广泛应用。有几篇文章概述了电化学检测和高效富集 CAs 的方法,但有关 CAs 在疾病发病机制中的作用的最新研究成果却很少。此外,目前仍缺乏以电化学检测用改性电极为重点的系统综述。因此,本综述对 2017 年至 2022 年间发表的最新 CAs 临床发病机制和用于电化学检测的改性电极进行了总结。此外,还强调了面临的挑战和未来展望。这项工作有望为进入这一交叉学科领域的研究人员提供有益的指导,促进CAs发病机制的进一步发展,并开发出更多用于检测CAs的新型化学修饰电极。
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引用次数: 0
Chromatographic Methods for the Determination of Organic Pollution in Urban Water: A Current Mini Review. 测定城市水体中有机污染的色谱法:最新小型综述。
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-03-07 DOI: 10.1080/10408347.2024.2318764
Paulina Gątarek, Angelina Rosiak, Joanna Kałużna-Czaplińska

The number of pollutants and chemicals with the potential to reach the environment is still largely unknown, which poses great challenges for researchers in various fields of science, environmental scientists, and analytical chemists. Chromatographic techniques, both gas chromatography (GC) and liquid chromatography (LC) coupled with different types of detection, are now invaluable tools for the identification of a wide range of chemical compounds and contaminants in water. This review is devoted to chromatographic techniques GC-MS, GC-Orbitrap-MS, GC-MS/MS, GC-HRMS, GC × GC-TOFMS, GC-ECD, LC-MS/MS, HPLC-UV, HPLC-PDA, UPLC-QTOFMS, used to determinate emerging organic contaminants in aquatic media, mainly in urban water, published in the scientific literature over the past several years. The article also focuses on sample preparation methods used in the analysis of aqueous samples. Most research focuses on minimizing the number of sample preparation steps, reducing the amount of solvents used, the speed of analysis, and the ability to apply it to a wide range of analytes in a sample. This is extremely important in the application of sensitive and selective methods to monitor the status of urban water quality and assess its impact on human health.

有可能进入环境中的污染物和化学品的数量在很大程度上仍是未知数,这给各科学领域的研究人员、环境科学家和分析化学家带来了巨大挑战。色谱技术,包括气相色谱(GC)和液相色谱(LC),再加上不同类型的检测,现已成为鉴定水中各种化合物和污染物的宝贵工具。本综述主要介绍过去几年发表在科学文献中的用于测定水生介质(主要是城市水体)中新出现的有机污染物的色谱技术:GC-MS、GC-Orbitrap-MS、GC-MS/MS、GC-HRMS、GC × GC-TOFMS、GC-ECD、LC-MS/MS、HPLC-UV、HPLC-PDA、UPLC-QTOFMS。文章还重点介绍了用于分析水样的样品制备方法。大多数研究的重点是尽量减少样品制备步骤、减少溶剂用量、提高分析速度以及将其应用于样品中多种分析物的能力。这对于应用灵敏的选择性方法监测城市水质状况和评估其对人类健康的影响极为重要。
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引用次数: 0
Mechanistic Insight Into the Reactivity of Frustrated Lewis Pairs: Liquid-State NMR Studies. 从机理上洞察受挫路易斯配对的反应性:液态核磁共振研究。
IF 5 2区 化学 Q1 Chemistry Pub Date : 2024-03-06 DOI: 10.1080/10408347.2024.2324299
Xinhui Kou

Frustrated Lewis pairs (FLPs) have been widely investigated as promising catalysts due to their metal-free feature and ability to activate small molecules. Over the last few years, the structure, dynamics and interactions between the Lewis centers and their effects on the reactivity with different substrates have been studied. Nuclear magnetic resonance (NMR) is a powerful tool in studying the reaction intermediates, kinetics and mechanism of frustrated Lewis pairs (FLPs). Various NMR experiments have been applied to precisely determine the association or cooperativity of FLPs and one or two-dimensional spectra were obtained. Herein, insights coming from NMR spectroscopy for FLPs are presented, the structure and reactivity of FLPs in solution are described, and their effects on the kinetics and mechanism of different substrates are also illustrated in this review.

受挫路易斯对(FLPs)因其无金属特性和活化小分子的能力而被广泛研究,是一种很有前景的催化剂。过去几年中,人们一直在研究路易斯中心的结构、动力学和相互作用,以及它们对不同底物反应活性的影响。核磁共振(NMR)是研究受挫路易斯对(FLPs)的反应中间体、动力学和机理的有力工具。各种核磁共振实验已被用于精确确定 FLPs 的关联性或合作性,并获得了一维或二维光谱。本综述介绍了核磁共振光谱对 FLPs 的启示,描述了 FLPs 在溶液中的结构和反应性,并说明了它们对不同底物的动力学和机理的影响。
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引用次数: 0
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Critical reviews in analytical chemistry
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