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Terahertz Channel Modeling, Estimation and Localization in RIS-Assisted Systems ris辅助系统中的太赫兹信道建模、估计和定位
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-25 DOI: 10.1002/aelm.202500590
Hongjing Wang, Weipeng Wang, Xuan Cong, Shiyu Wang, Gao Li, Sen Gong, Lin Huang, Hongxin Zeng, Yaxin Zhang, Ziqiang Yang
Terahertz (THz) communication has emerged as a pivotal research directions for the sixth-generation (6G) mobile communication systems, owing to its outstanding potential in ultra-high data rates, extremely low latency, and massive capacity. Metasurface technology, particularly reconfigurable intelligent surfaces (RIS), as a disruptive approach for electromagnetic wave manipulation, offers a novel pathway to overcome the channel propagation limitations in THz communications. It significantly accelerates the development of dynamic THz functional devices and promotes their practical application in real-world systems. This article provides a systematic review of recent advances in three interconnected areas of RIS-assisted THz communication systems: channel modeling, channel estimation, and localization. In channel modeling, innovative theoretical frameworks address near-field effects in large-scale arrays and complex propagation environments. For channel estimation, efficient methods leverage sparsity and low-rank properties, alongside artificial intelligence-driven joint optimization strategies. Localization research emphasizes high-precision near-field architectures and their integration in sophisticated systems such as integrated sensing and communication, with added analysis of performance potential. This review aims to serve as a comprehensive reference for researchers working on channel-related technologies in THz RIS-assisted communications and to stimulate further research and practical applications toward future intelligent communication systems.
太赫兹(THz)通信由于其超高数据速率、极低延迟和大容量等方面的突出潜力,已成为第六代(6G)移动通信系统的关键研究方向。超表面技术,特别是可重构智能表面(RIS),作为一种颠覆性的电磁波操纵方法,为克服太赫兹通信中的信道传播限制提供了一种新的途径。它大大加快了动态太赫兹功能器件的发展,促进了它们在现实系统中的实际应用。本文系统地回顾了ris辅助太赫兹通信系统的三个相互关联领域的最新进展:信道建模、信道估计和定位。在信道建模中,创新的理论框架解决了大规模阵列和复杂传播环境中的近场效应。对于信道估计,有效的方法利用稀疏性和低秩属性,以及人工智能驱动的联合优化策略。本地化研究强调高精度近场架构及其在集成传感和通信等复杂系统中的集成,并增加对性能潜力的分析。本文旨在为太赫兹ris辅助通信中信道相关技术的研究人员提供综合参考,并促进未来智能通信系统的进一步研究和实际应用。
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引用次数: 0
Bio-Inspired Mechanical Amplification Block on Implantable Tactile Sensors 植入式触觉传感器的仿生机械放大块
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-25 DOI: 10.1002/aelm.202500874
Sungbin Choi, Yeong-sinn Ye, Chanho Jeong, Yujin Mun, Suyoun Oh, Tae-il Kim
Implantable strain sensors offer opportunities for continuous biomechanical monitoring, but their performance deteriorates severely once embedded in soft tissue due to mechanical shielding that suppresses strain transmission to the sensing layer. Here, we present a bio-inspired mechanical amplification (MA) strategy that restores high sensitivity in compliant environments by reengineering the deformation pathway surrounding a crack-based strain sensor. A rigid microscale MA block, positioned on the sensing layer, induces deformation asymmetry under external loading, redirecting compressive forces into localized bending and tensile strain that effectively opens nanoscale cracks. Through theoretical modeling, FEM analysis, and experimental validation, we demonstrate that the amplification magnitude is precisely tunable by MA block height, sensor embedding depth, block shape, and modulus contrast between the block and the surrounding elastomer matrix. This MA design principle enhances single sensor sensitivity by more than an order of magnitude (∼11.08×) and maintains stable performance across multi-pixel arrays, enabling high-resolution tactile mapping even when deeply embedded within soft substrates. The MA strategy thus provides a generalized framework for overcoming mechanical shielding and offers a pathway toward next-generation implantable tactile interfaces and soft bioelectronic systems requiring high sensitivity and robust performance in mechanically dissipative environments.
植入式应变传感器为连续的生物力学监测提供了机会,但由于机械屏蔽抑制了应变传递到传感层,一旦嵌入软组织,其性能就会严重恶化。在这里,我们提出了一种仿生机械放大(MA)策略,通过重新设计基于裂纹的应变传感器周围的变形路径,在顺应环境中恢复高灵敏度。放置在传感层上的刚性微尺度MA块在外部载荷下诱导变形不对称,将压缩力重定向为局部弯曲和拉伸应变,从而有效地打开纳米级裂纹。通过理论建模、有限元分析和实验验证,我们证明了放大幅度可以通过MA块高度、传感器嵌入深度、块形状以及块与周围弹性体矩阵之间的模量对比精确调节。这种MA设计原理将单个传感器灵敏度提高了一个数量级以上(~ 11.08×),并在多像素阵列中保持稳定的性能,即使深嵌入软基板中也能实现高分辨率触觉映射。因此,MA策略为克服机械屏蔽提供了一个通用框架,并为在机械耗散环境中需要高灵敏度和鲁棒性能的下一代植入式触觉界面和软生物电子系统提供了一条途径。
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引用次数: 0
Model-Based Time-Modulated Write Algorithm for 1R Analog Memristive Crossbar Arrays 基于模型的1R模拟忆阻交叉棒阵列时调制写算法
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-23 DOI: 10.1002/aelm.202500777
Richard Schroedter, Ahmet Samil Demirkol, Ioannis Messaris, Christian Bruchatz, Eter Mgeladze, Stefan Slesazeck, Thomas Mikolajick, Ronald Tetzlaff
Memristive crossbar arrays are a key technology for analog in-memory computing in AI accelerators and neuromorphic systems. The inherent device nonlinearities are advantageous, suppressing sneak-path currents in selector-less (1R) arrays, enabling 3D back-end-of-line integration, and ensuring read stability against the voltage-time dilemma. However, these same properties, combined with device variability, IR drop, and parasitic effects, severely challenge precise programming. Conventional amplitude-modulated write-verify algorithms are consequently slow, energy-intensive, and limited by write endurance. Here, a time-modulated write algorithm is introduced, specifically designed for analog-switching 1R crossbars. It employs a single programming voltage, varying only the write pulse duration. The algorithm leverages a compact model to estimate an initial optimal write time, which is then refined by a dynamic gain mechanism that rapidly compensates for deviations arising from non-ideal effects. The method's performance is validated through SPICE simulations of a physics-based Nb2O5�${rm Nb}_2{rm O}_5$�/Al2O3�${rm Al}_2{rm O}_3$� model across various crossbar sizes and V/2, V/3 and floating biasing schemes. The results demonstrate that the time-modulated approach significantly reduces write iterations and total programming time, while simultaneously lowering energy consumption and improving final conductance accuracy. This proposed algorithm enables faster, more energy-efficient weight updates and restoration in memristive neural network accelerators.
忆阻交叉杆阵列是人工智能加速器和神经形态系统中模拟内存计算的关键技术。固有的器件非线性是有利的,可以抑制无选择器(1R)阵列中的潜径电流,实现3D后端线集成,并确保在电压-时间困境下的读取稳定性。然而,这些相同的特性,加上器件可变性、IR下降和寄生效应,严重挑战了精确编程。因此,传统的调幅写验证算法速度慢、耗能大,而且受写入持久性的限制。本文介绍了一种专为模拟开关1R交叉棒设计的时调制写入算法。它采用单一编程电压,仅改变写入脉冲持续时间。该算法利用一个紧凑的模型来估计初始的最佳写入时间,然后通过动态增益机制进行改进,该机制可以快速补偿由非理想效果引起的偏差。通过SPICE仿真验证了基于物理的Nb2O5${rm Nb}_2{rm O}_5$/Al2O3${rm Al}_2{rm O}_3$模型在不同横条尺寸和V/2、V/3和浮动偏置方案下的性能。结果表明,时间调制方法显著减少了写入迭代和总编程时间,同时降低了能耗,提高了最终电导精度。该算法能够在记忆性神经网络加速器中实现更快、更节能的权重更新和恢复。
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引用次数: 0
Large Field-Like Orbital Torque in FeNi/Cr Heterostructures FeNi/Cr异质结构中的大类场轨道转矩
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-23 DOI: 10.1002/aelm.202500838
Zhendong Chen, Wenjing Zhong, Shun Wang, Zhongxiang Zhang, Xiangyu Zheng, Yongbing Xu, Peiyan Liu, Wenjing Hu, Xinbao Geng, Chen Yao, Tiejun Zhou, Bo Liu, Guanqi Li, Sheng Jiang, Junlin Wang, Jing Wu
Orbital torque is one of the potential approaches to achieve current-driven magnetization switching in next-generation spintronic devices, where the field-like orbital torque plays a critical role to obtain field-free magnetization switching. Here, we report a large field-like orbital torque observed in FeNi/Cr heterostructures by the symmetric components of the spin-torque ferromagnetic resonance signals, which induced a sin2θ symmetry in the angular dependence of the symmetric component amplitudes. This field-like orbital torque is along the m × z direction, with an efficiency (−0.033) comparable to that of the damping-like torque (0.068). A significant tilting of the orbital current polarization generated by the orbital Hall effect in the Cr layer leads to the z-component of the orbital current polarization and the large field-like orbital torque. Furthermore, the y-component of the orbital current polarization shows a reversal behavior as the Cr thickness decreases, demonstrating the competition between the orbital currents generated by the surface oxide layer and those within the Cr bulk. These findings provide insights into the orbital torques in the 3d transition metals and highlight the potential of orbital-torque-driven magnetization switching in the absence of external magnetic fields for the applications of spintronic devices.
轨道转矩是下一代自旋电子器件实现电流驱动磁化开关的潜在途径之一,类场轨道转矩在实现无场磁化开关中起着至关重要的作用。本文报道了通过自旋转矩铁磁共振信号的对称分量在FeNi/Cr异质结构中观察到一个大的类场轨道转矩,这使得对称分量振幅的角依赖性产生了sin2θ对称性。这种类场轨道转矩沿m × z方向,效率(- 0.033)与类阻尼转矩(0.068)相当。由于轨道霍尔效应在Cr层中引起轨道电流极化的明显倾斜,导致轨道电流极化的z分量和较大的类场轨道转矩。此外,轨道电流极化的y分量随Cr厚度的减小呈现出反转行为,表明表面氧化层产生的轨道电流与Cr体内部产生的轨道电流之间存在竞争。这些发现为三维过渡金属中的轨道转矩提供了见解,并突出了在没有外部磁场的情况下轨道转矩驱动磁化开关在自旋电子器件应用中的潜力。
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引用次数: 0
A Compendium of Logic Gates Based on Reconfigurable Three-Independent-Gate Transistors Realized in FDSOI Hardware 基于FDSOI硬件实现的可重构三独立栅极晶体管的逻辑门概要
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-23 DOI: 10.1002/aelm.202500782
Juan P. Martinez, Yuxuan He, Giulio Galderisi, Violetta Sessi, Niladri Bhattacharjee, Peter Baars, Kerstin Poenisch, Annekathrin Zeun, Konstantin Li, Fernando Koch, Binit Syamal, Thomas Mikolajick, Jens Trommer
This work presents the electrical characterization of sixteen different logic gates built entirely from three-independent-gate reconfigurable transistors. The circuits are fabricated on full-scale 300 mm wafers using the industrial 22 nm fully depleted silicon-on-insulator process of GlobalFoundries, with only minimal modifications to the baseline CMOS flow. The demonstrations include a reconfigurable 2-2 AND-OR-Inverter gate and a fully functional 1-bit adder comprising eight transistors. Quasi-static and transient on-wafer measurements confirm correct functionality and provide insight into the frequency limitations imposed by the current design and test setup. Finally, to explore scalability, a ripple-carry adder is simulated based on the experimentally realized 1-bit adder, illustrating how scaled devices and optimized layouts could enable low-power, CMOS-compatible applications.
这项工作提出了完全由三个独立栅极可重构晶体管构建的16个不同逻辑门的电气特性。该电路是在全尺寸300mm晶圆上制造的,采用GlobalFoundries的工业22nm完全耗尽绝缘体上硅工艺,仅对基准CMOS流程进行了最小的修改。演示包括一个可重构的2-2与或逆变器门和一个由8个晶体管组成的全功能1位加法器。准静态和瞬态晶圆上测量确认了正确的功能,并提供了对当前设计和测试设置所施加的频率限制的见解。最后,为了探索可扩展性,基于实验实现的1位加法器对纹波进位加法器进行了仿真,说明了缩放器件和优化布局如何实现低功耗、cmos兼容的应用。
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引用次数: 0
Recent Advances in Programmable Metasurfaces and Meta-Devices 可编程元表面和元器件的最新进展
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-23 DOI: 10.1002/aelm.202500818
Linda Shao, Chong He, Nan Wang, Liming Si, Weiren Zhu
Programmable metasurfaces enable various novel functionalities, including real-time beam steering, high-resolution imaging, adaptive wireless communications, and so on, by dynamically tuning electromagnetic wavefronts. These capabilities hold significant promise for transformative applications in reconfigurable antennas, smart sensing systems, and encrypted data transmission within emerging 5G/6G networks. In this article, we provide a comprehensive review of recent advances in microwave and terahertz programmable metasurfaces, encompassing various control mechanisms including electrical, thermal, optical and mechanical tuning. We begin by discussing electrically controlled metasurfaces based on Positive-Intrinsic-Negative(PIN) diodes or varactor diodes, highlighting their reconfigurable applications in beam scanning, imaging, and wireless communications. The review then explores the distinct advantages of liquid crystals and graphene in achieving dynamic electromagnetic control, along with representative devices. Additionally, we analyze thermally controlled metasurfaces that utilize <span data-altimg="/cms/asset/64548522-b4a7-49ad-bd33-caa25aa7ec22/aelm70334-math-0001.png"></span><mjx-container ctxtmenu_counter="2" ctxtmenu_oldtabindex="1" jax="CHTML" role="application" sre-explorer- style="font-size: 103%; position: relative;" tabindex="0"><mjx-math aria-hidden="true" location="graphic/aelm70334-math-0001.png"><mjx-semantics><mjx-msub data-semantic-children="0,1" data-semantic- data-semantic-role="unknown" data-semantic-speech="upper V upper O 2" data-semantic-type="subscript"><mjx-mi data-semantic-font="normal" data-semantic- data-semantic-parent="2" data-semantic-role="unknown" data-semantic-type="identifier"><mjx-c></mjx-c><mjx-c></mjx-c></mjx-mi><mjx-script style="vertical-align: -0.15em;"><mjx-mn data-semantic-annotation="clearspeak:simple" data-semantic-font="normal" data-semantic- data-semantic-parent="2" data-semantic-role="integer" data-semantic-type="number" size="s"><mjx-c></mjx-c></mjx-mn></mjx-script></mjx-msub></mjx-semantics></mjx-math><mjx-assistive-mml display="inline" unselectable="on"><math altimg="urn:x-wiley:2199160X:media:aelm70334:aelm70334-math-0001" display="inline" location="graphic/aelm70334-math-0001.png" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><msub data-semantic-="" data-semantic-children="0,1" data-semantic-role="unknown" data-semantic-speech="upper V upper O 2" data-semantic-type="subscript"><mi data-semantic-="" data-semantic-font="normal" data-semantic-parent="2" data-semantic-role="unknown" data-semantic-type="identifier">VO</mi><mn data-semantic-="" data-semantic-annotation="clearspeak:simple" data-semantic-font="normal" data-semantic-parent="2" data-semantic-role="integer" data-semantic-type="number">2</mn></msub>${rm VO}_2$</annotation></semantics></math></mjx-assistive-mml></mjx-container> and chalcogenide phase-change materials, as well as optically controlled metasurfaces driven by structu
可编程元表面通过动态调整电磁波前实现各种新功能,包括实时波束控制、高分辨率成像、自适应无线通信等。这些功能为可重构天线、智能传感系统和新兴5G/6G网络中的加密数据传输的变革性应用带来了巨大的希望。在本文中,我们全面回顾了微波和太赫兹可编程超表面的最新进展,包括各种控制机制,包括电,热,光学和机械调谐。我们首先讨论基于正本征负(PIN)二极管或变容二极管的电控超表面,重点介绍它们在波束扫描、成像和无线通信中的可重构应用。然后,本文探讨了液晶和石墨烯在实现动态电磁控制方面的独特优势,以及具有代表性的器件。此外,我们还分析了利用VO2${rm VO}_2$和硫系相变材料的热控超表面,以及由结构光和激光激发驱动的光控超表面。本文还讨论了基于微机电系统的可编程元表面。最后,综述总结了可编程元表面的实际应用,并解决了当前的挑战,如响应速度、功耗和集成密度。最后,我们对这一快速发展的研究领域存在的挑战和未来的发展方向进行了展望。
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引用次数: 0
Photoresponsive Rotaxanes Switch Lipid Bilayer Neuromorphic Behavior with Light 光响应轮烷在光下改变脂质双分子层的神经形态行为
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-23 DOI: 10.1002/aelm.202500759
P.T. Podar, U.N.K. Conthagamage, J. Katsaras, V. García-López, C. P. Collier
A rotaxane consisting of a macrocycle ring with two azobenzene units mechanically interlocked onto a bolaamphiphilic axle was incorporated into droplet interface bilayers (DIBs). The azobenzene groups on the ring underwent quasi-reversible, photoisomerization-induced cycling between 1-E and 1-Z configurations when irradiated with 370 and 467 nm light, respectively, enabling programmable access to different history-dependent electrical behaviors from the same membrane. In the 1-E configuration, bilayers exhibited type-IIactive memristance that coincided with increasingly elevated ionic conduction, associated with progressively enhanced bilayer permeability during voltage cycling. In the 1-Z configuration, bilayers displayed type-I, passive memcapacitive behavior, reflecting tighter lipid packing and reduced ionic permeability. Photoswitching also yielded a nonvolatile, photoresponsive memcapacitor that could be modulated repetitively with negligible loss, likely via reversible changes in membrane thickness. Concurrent ohmic leakage currents across the membrane were less than 0.3%. These results agree with previous studies with increasing membrane permeability using photoswitchable rotaxanes and provide new insights into the coupling between volatile and nonvolatile memcapacitance during photoisomerization. More broadly, they demonstrate a new strategy for the manipulation of neuromorphic behaviors in soft materials using light, with implications for brain-inspired computation and sensing.
在液滴界面双分子层(dib)中加入了一种由大环和两个偶氮苯单元组成的轮烷,该环与两个偶氮苯单元机械联锁在一个bolaamphi亲性轴上。在370 nm和467 nm的光照射下,环上的偶氮苯基分别在1-E和1-Z构型之间进行了准可逆的光异构化诱导循环,从而可以从同一膜上可编程地访问不同的历史相关电行为。在1-E结构中,双分子层表现出ii型活性忆阻,与电压循环过程中离子导电性的增加相一致,并与双分子层渗透率的逐渐增强有关。在1-Z结构中,双层膜表现出i型被动记忆电容行为,反映了更紧密的脂质堆积和降低的离子渗透性。光开关还产生了一种非易失性、光响应的memcapacitor,可以通过膜厚度的可逆变化,以可忽略不计的损失重复调制。通过膜的并发欧姆漏电流小于0.3%。这些结果与先前使用光开关轮烷增加膜通透性的研究一致,并为光异构过程中挥发性和非挥发性膜电容之间的耦合提供了新的见解。更广泛地说,他们展示了一种利用光操纵软材料中神经形态行为的新策略,这对大脑启发的计算和感知具有启示意义。
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引用次数: 0
Capacitive versus Faradaic Microelectrodes for Extracellular Stimulation: A Fully Coupled FEM–Hodgkin–Huxley Study of Thresholds and Current Redistribution 电容与法拉第微电极用于细胞外刺激:阈值和电流再分配的完全耦合FEM-Hodgkin-Huxley研究
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-23 DOI: 10.1002/aelm.202500867
Aleksandar Opančar, Eric Daniel Głowacki, Vedran Đerek
Extracellular microstimulation depends on neuronal excitability and on how current enters the electrolyte through the electrode–electrolyte interface and the cell–electrode cleft. Here we compare two ideal interface limits—capacitive (polarizable) and Faradaic (non-polarizable)—using a fully coupled finite-element model linked to a Hodgkin–Huxley neuron with an explicit axon initial segment. Using square current pulses, we quantify activation thresholds as the charge delivered per unit electrode area. We consider 10 µm (AIS-aligned) and 100 µm (soma-aligned) disk electrodes and vary the cleft gap from 100 nm to 2 µm, spanning typical adherent multielectrode-array conditions. Across all geometries, capacitive interfaces require less charge density to trigger spikes than Faradaic interfaces, with the advantage increasing in tighter clefts. Time-resolved maps show that both interfaces initially exhibit edge crowding; however, capacitive charging locally increases interfacial impedance and redistributes current toward regions beneath the cell, whereas Faradaic contacts remain near-equipotential and sustain an edge-dominated pattern. All operating points fall below conservative Shannon safety limits. These results clarify when capacitive microelectrodes can outperform Faradaic ones under current control and provide guidance for MEA design.
细胞外微刺激取决于神经元的兴奋性以及电流如何通过电极-电解质界面和细胞-电极间隙进入电解质。在这里,我们比较了两种理想的界面限制-电容(极化)和法拉第(非极化)-使用一个完全耦合的有限元模型连接到霍奇金-赫胥黎神经元与一个明确的轴突初始段。使用方电流脉冲,我们量化激活阈值作为每单位电极面积交付的电荷。我们考虑了10µm (ais对准)和100µm (soma对准)的圆盘电极,并将间隙从100 nm改变到2µm,跨越典型的贴附多电极阵列条件。在所有几何形状中,电容界面比法拉第界面需要更少的电荷密度来触发尖峰,并且在更紧密的间隙中增加优势。时间分辨图显示,两个界面最初都表现出边缘拥挤;然而,电容性充电局部增加了界面阻抗,并将电流重新分配到电池下方的区域,而法拉第接触保持接近等电位并维持边缘主导模式。所有的操作点都低于保守的香农安全限制。这些结果阐明了电容微电极在电流控制下何时能优于法拉第微电极,并为电容微电极的设计提供了指导。
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引用次数: 0
Chronic Disease Monitoring Using Advanced Compliant Materials for Bioelectronics 使用生物电子学先进兼容材料的慢性疾病监测
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-23 DOI: 10.1002/aelm.202500885
Han Kim, Mabel Bartlett, Liyang Wang, Karl Bates, Mengdi He, Myungbo Kim, Carmel Majidi, Tzahi Cohen-Karni
Chronic disease arises slowly through complex physiological factors that require continuous monitoring and treatment. Compliant bioelectronics with soft, stretchable, and tissue-conformal designs allow for in vivo continuous monitoring through electrophysiological, mechanical, and biochemical modalities, while minimizing tissue irritation and immune system response. In this review, we discuss recent progress in material development, device design, and versatile sensing modalities that allow stable long-term operation in dynamic biological environments. We focus on chronic electrophysiological systems for neural and cardiac recording, mechanical sensing systems for strain and pressure, and electrochemical sensors for molecular biomarkers. In addition, we examine self-powered bioelectronics based on piezoelectric and triboelectric energy conversion mechanisms that eliminate the requirement for external batteries, whereas multimodal and closed-loop systems combine sensing with therapeutic feedback. We consider key parameters like material biocompatibility, device flexibility, and long-term stability that are required for chronic monitoring to maintain stable signal quality over long time periods relevant for clinical recordings. These technologies for compliant bioelectronics enable early disease diagnosis, personalized treatment and continuous intervention for patients, narrowing the gap between laboratory study and routine clinical applications.
慢性疾病通过复杂的生理因素缓慢发生,需要持续监测和治疗。柔顺的生物电子产品具有柔软,可拉伸和组织适形设计,可以通过电生理,机械和生化方式进行体内连续监测,同时最大限度地减少组织刺激和免疫系统反应。在这篇综述中,我们讨论了在动态生物环境中长期稳定运行的材料开发、设备设计和多功能传感模式方面的最新进展。我们专注于神经和心脏记录的慢性电生理系统,应变和压力的机械传感系统,以及分子生物标志物的电化学传感器。此外,我们研究了基于压电和摩擦电能量转换机制的自供电生物电子学,消除了对外部电池的需求,而多模态和闭环系统将传感与治疗反馈相结合。我们考虑了慢性监测所需的关键参数,如材料生物相容性、设备灵活性和长期稳定性,以便在与临床记录相关的长时间内保持稳定的信号质量。这些符合生物电子学的技术使早期疾病诊断、个性化治疗和患者的持续干预成为可能,缩小了实验室研究和常规临床应用之间的差距。
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引用次数: 0
Organic Electrochemical Transistors and Foreign Body Reaction: First Steps Toward Long-Term Implantable Biosensing 有机电化学晶体管和异物反应:迈向长期植入式生物传感的第一步
IF 6.2 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2026-03-23 DOI: 10.1002/aelm.202500737
Henrique Frulani de Paula Barbosa, Titinun Nuntapramote, Ankush Kumar, Sander van den Driesche, Michael J. Vellekoop, Dorothea Brüggemann, Björn Lüssem
Organic Electrochemical Transistors (OECT) have been widely used to detect a myriad of analytes and signals, ranging from glucose content in sweat to brain epileptiform activity. Due to their biocompatibility, small footprint, conformability, and high signal amplification, OECTs can not only be used in wearable, but also in implanted sensor systems, providing superior signal quality. However, although there is a risk of triggering the Foreign Body Reaction (FBR) with implantation, FBR impact on OECTs has rarely been discussed. Therefore, here we evaluate the effect of the FBR fibrotic response on OECT performance, i.e. when the OECT is covered by protein layers, in vitro. In more detail, we analyze poly(3,4-ethylenedioxythiophene):poly (styrene-sulfonate) (PEDOT:PSS) based OECTs and intentionally cover their channels with protein layers commonly formed during FBR, such as albumin, collagen and fibrinogen. Despite slightly increasing devices' switching time, proteins do not hamper their operation. Further coverage by yeast cells as a proof of concept of wound healing process also did not jeopardize OECT functioning, indicating devices could resist the FBR fibrotic response without anti-FBR strategies.
有机电化学晶体管(OECT)已被广泛用于检测各种分析物和信号,从汗液中的葡萄糖含量到脑癫痫样活动。由于其生物相容性,占地面积小,一致性和高信号放大,oect不仅可以用于可穿戴设备,还可以用于植入传感器系统,提供卓越的信号质量。然而,尽管植入有引发异物反应(FBR)的风险,但FBR对oect的影响很少被讨论。因此,在这里,我们在体外评估FBR纤维化反应对OECT性能的影响,即当OECT被蛋白质层覆盖时。更详细地说,我们分析了聚(3,4-乙烯二氧噻吩):聚(苯乙烯-磺酸盐)(PEDOT:PSS)为基础的oect,并有意用FBR过程中常见的蛋白质层覆盖它们的通道,如白蛋白、胶原蛋白和纤维蛋白原。尽管稍微增加了设备的切换时间,蛋白质并不妨碍它们的运行。酵母细胞的进一步覆盖作为伤口愈合过程概念的证明,也没有损害OECT的功能,这表明设备可以在没有抗FBR策略的情况下抵抗FBR纤维化反应。
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Advanced Electronic Materials
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