Pub Date : 2026-02-01Epub Date: 2025-12-13DOI: 10.1016/j.coelec.2025.101805
Huang Zhang , Yang Wang , Zhihao Zhao , Xu Liu , Stefano Passerini
The emergence of anode-free aqueous zinc metal batteries (AF-ZMBs) represents a transformative approach that combines intrinsic safety and low cost with maximized energy density. While significant research has focused on electrolyte optimization and interface engineering to enhance zinc reversibility, comprehensive analysis of cathode chemistry specifically tailored for anode-free configurations remains limited. This review systematically examines recent advancements in innovative cathode design strategies, spanning intercalation, hybrid-ion, dual-ion, and conversion mechanisms, and analyzes their respective capabilities in maintaining zinc inventory and structural stability. By critically assessing the current landscape and future potential of these cathode systems, this work aims to establish fundamental design principles for developing practical anode-free zinc battery technologies.
{"title":"Cathode chemistry innovations in anode-free aqueous zinc metal batteries","authors":"Huang Zhang , Yang Wang , Zhihao Zhao , Xu Liu , Stefano Passerini","doi":"10.1016/j.coelec.2025.101805","DOIUrl":"10.1016/j.coelec.2025.101805","url":null,"abstract":"<div><div>The emergence of anode-free aqueous zinc metal batteries (AF-ZMBs) represents a transformative approach that combines intrinsic safety and low cost with maximized energy density. While significant research has focused on electrolyte optimization and interface engineering to enhance zinc reversibility, comprehensive analysis of cathode chemistry specifically tailored for anode-free configurations remains limited. This review systematically examines recent advancements in innovative cathode design strategies, spanning intercalation, hybrid-ion, dual-ion, and conversion mechanisms, and analyzes their respective capabilities in maintaining zinc inventory and structural stability. By critically assessing the current landscape and future potential of these cathode systems, this work aims to establish fundamental design principles for developing practical anode-free zinc battery technologies.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"55 ","pages":"Article 101805"},"PeriodicalIF":6.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-12-09DOI: 10.1016/j.coelec.2025.101801
Maxwell D. Bridges , Charles S. Henry
Electroanalytical chemistry has found incredible importance in diagnostics, healthcare, environmental monitoring and many other applications. One challenge for electroanalytical chemistry, however, is the ability to handle complex samples and/or differentiate between analytes with similar redox potentials. Historically, electrochemistry has been coupled with separation methods like liquid chromatography and capillary electrophoresis to address this problem, but this resulted in complex equipment that could not be used at the point-of-care (POC) or point-of-need (PON). With the advent of microfluidics in the 1990s, hope arose again for small, fast, accurate POC/PON devices that could address critical diagnostic needs. The first reports of electrochemistry coupled with paper-based devices followed thereafter and now the field has exploded with contributions from around the globe. This review focuses on recent advances in the field, covering roughly two years of developments with both fabrication and applications before concluding with a summary, remaining challenges, and future directions.
{"title":"Recent advances in electrochemical capillary flow microfluidic devices","authors":"Maxwell D. Bridges , Charles S. Henry","doi":"10.1016/j.coelec.2025.101801","DOIUrl":"10.1016/j.coelec.2025.101801","url":null,"abstract":"<div><div>Electroanalytical chemistry has found incredible importance in diagnostics, healthcare, environmental monitoring and many other applications. One challenge for electroanalytical chemistry, however, is the ability to handle complex samples and/or differentiate between analytes with similar redox potentials. Historically, electrochemistry has been coupled with separation methods like liquid chromatography and capillary electrophoresis to address this problem, but this resulted in complex equipment that could not be used at the point-of-care (POC) or point-of-need (PON). With the advent of microfluidics in the 1990s, hope arose again for small, fast, accurate POC/PON devices that could address critical diagnostic needs. The first reports of electrochemistry coupled with paper-based devices followed thereafter and now the field has exploded with contributions from around the globe. This review focuses on recent advances in the field, covering roughly two years of developments with both fabrication and applications before concluding with a summary, remaining challenges, and future directions.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"55 ","pages":"Article 101801"},"PeriodicalIF":6.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-15DOI: 10.1016/j.coelec.2025.101784
Zhongxi Zhao , Yongfu Liu , Jianwen Yu , Jiangfeng Huang , Junshuo Lian , Yaoming Leng , Peng Tan
The application of rechargeable zinc-air batteries (RZABs) is hindered by sluggish oxygen reaction kinetics at air electrodes and poor reversibility of zinc electrodes. This work analyzes the fundamental issues limiting the practical implementation of RZABs and proposes a practical application-oriented performance evaluation framework. For air electrodes, in-situ gas monitoring techniques are critically needed to accurately distinguish the electrochemical reaction pathways during the charging process of transition metal catalysts and the competitive mechanisms between carbon corrosion and oxygen evolution reactions. With respect to zinc electrodes, conventional low depth of discharge (DOD) testing conditions mask irreversible capacity loss under practical high-DOD (>20 %) operation, necessitating the establishment of a “limited zinc-high DOD” system to reliably assess electrode performance. Furthermore, full-cell design requires optimization of key parameters. The standardized evaluation framework proposed herein not only provides critical guidance for the industrialization of RZABs but also can be extended to other metal-air battery systems.
{"title":"Critical metrics for practical application-oriented rechargeable zinc-air batteries","authors":"Zhongxi Zhao , Yongfu Liu , Jianwen Yu , Jiangfeng Huang , Junshuo Lian , Yaoming Leng , Peng Tan","doi":"10.1016/j.coelec.2025.101784","DOIUrl":"10.1016/j.coelec.2025.101784","url":null,"abstract":"<div><div>The application of rechargeable zinc-air batteries (RZABs) is hindered by sluggish oxygen reaction kinetics at air electrodes and poor reversibility of zinc electrodes. This work analyzes the fundamental issues limiting the practical implementation of RZABs and proposes a practical application-oriented performance evaluation framework. For air electrodes, in-situ gas monitoring techniques are critically needed to accurately distinguish the electrochemical reaction pathways during the charging process of transition metal catalysts and the competitive mechanisms between carbon corrosion and oxygen evolution reactions. With respect to zinc electrodes, conventional low depth of discharge (DOD) testing conditions mask irreversible capacity loss under practical high-DOD (>20 %) operation, necessitating the establishment of a “limited zinc-high DOD” system to reliably assess electrode performance. Furthermore, full-cell design requires optimization of key parameters. The standardized evaluation framework proposed herein not only provides critical guidance for the industrialization of RZABs but also can be extended to other metal-air battery systems.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"55 ","pages":"Article 101784"},"PeriodicalIF":6.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-30DOI: 10.1016/j.coelec.2025.101792
Ran Ren, Haoyu Dong, Guanchao He, Gonglan Ye, Huilong Fei
Zinc-air batteries (ZABs) possess high theoretical energy density and are environmentally friendly. However, the practical applications of ZABs are restricted by their relatively low power density, which is largely dictated by the mass transport efficiency of the air electrode. The construction of self-supported electrodes brings about various structural advantages like large specific surface area, abundant active sites, and mechanical integrity, and it is regarded as a feasible strategy to overcome the mass transport limitation of ZABs. In this review, the recent strategies for enhancing the mass transport of self-supported air electrode are elaborated, ending with the remaining challenges along with future perspective.
{"title":"Self-supported air cathode with enhanced mass transport for high-power zinc-air batteries","authors":"Ran Ren, Haoyu Dong, Guanchao He, Gonglan Ye, Huilong Fei","doi":"10.1016/j.coelec.2025.101792","DOIUrl":"10.1016/j.coelec.2025.101792","url":null,"abstract":"<div><div>Zinc-air batteries (ZABs) possess high theoretical energy density and are environmentally friendly. However, the practical applications of ZABs are restricted by their relatively low power density, which is largely dictated by the mass transport efficiency of the air electrode. The construction of self-supported electrodes brings about various structural advantages like large specific surface area, abundant active sites, and mechanical integrity, and it is regarded as a feasible strategy to overcome the mass transport limitation of ZABs. In this review, the recent strategies for enhancing the mass transport of self-supported air electrode are elaborated, ending with the remaining challenges along with future perspective.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"55 ","pages":"Article 101792"},"PeriodicalIF":6.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-10DOI: 10.1016/j.coelec.2025.101764
Andrzej Lasia
Porous electrodes are important in practical applications of electrochemistry. Single cylindrical pore models are first presented. In the presence of direct current (DC) DC potential and DC concentration gradients appear. These gradients are related to each other. Analytical solutions exist only in the absence of the DC potential gradient. When a concentration gradient is present, two semicircles appear on the complex plane plots. Solution resistivity in pores causes formation of the high frequency line at 45° on the complex plane plots.
However, the real pores are multidimensional containing macro, meso, and micro pores. Many models of inhomogeneous porosity were developed. Further models used Poisson–Nernst–Planck theory to include charge interactions. In very narrow pores, double layers of the pore walls overlap. Future challenge is to obtain pore parameters from the impedance measurements of complex systems.
{"title":"Impedance of porous electrodes","authors":"Andrzej Lasia","doi":"10.1016/j.coelec.2025.101764","DOIUrl":"10.1016/j.coelec.2025.101764","url":null,"abstract":"<div><div>Porous electrodes are important in practical applications of electrochemistry. Single cylindrical pore models are first presented. In the presence of direct current (DC) DC potential and DC concentration gradients appear. These gradients are related to each other. Analytical solutions exist only in the absence of the DC potential gradient. When a concentration gradient is present, two semicircles appear on the complex plane plots. Solution resistivity in pores causes formation of the high frequency line at 45° on the complex plane plots.</div><div>However, the real pores are multidimensional containing macro, meso, and micro pores. Many models of inhomogeneous porosity were developed. Further models used Poisson–Nernst–Planck theory to include charge interactions. In very narrow pores, double layers of the pore walls overlap. Future challenge is to obtain pore parameters from the impedance measurements of complex systems.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"54 ","pages":"Article 101764"},"PeriodicalIF":6.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-10DOI: 10.1016/j.coelec.2025.101767
Jenifer Rubio-Magnieto, Juan Bisquert
This review underscores the growing relevance of impedance spectroscopy (IS) in neuromorphic research and its capacity to advance brain-inspired computation. Neuromorphic systems, which emulate biological neural networks, provide compact, adaptive, and energy-efficient solutions for edge applications such as robotics, wearable health monitoring, and environmental sensing. Since early studies on electrochemical oscillators, IS has been pivotal in probing neuron-like dynamics. Frequency-domain analysis of artificial synapses yields essential insights into synaptic plasticity—the core mechanism of learning and memory—shaped by functions like retention and filtering. Memristor-based synapses display chemical inductor behavior, evident as a negative arc in impedance spectra, highlighting their complex dynamics. More broadly, IS is increasingly positioned not only as a diagnostic tool for material performance but also as a framework for designing systems governed by ion migration, accumulation, and relaxation. By capturing these processes, IS provides a powerful perspective for analyzing and engineering physical computation components.
{"title":"Impedance spectroscopy of neurons, inductors and synapses: A path to understanding brain-like computation","authors":"Jenifer Rubio-Magnieto, Juan Bisquert","doi":"10.1016/j.coelec.2025.101767","DOIUrl":"10.1016/j.coelec.2025.101767","url":null,"abstract":"<div><div>This review underscores the growing relevance of impedance spectroscopy (IS) in neuromorphic research and its capacity to advance brain-inspired computation. Neuromorphic systems, which emulate biological neural networks, provide compact, adaptive, and energy-efficient solutions for edge applications such as robotics, wearable health monitoring, and environmental sensing. Since early studies on electrochemical oscillators, IS has been pivotal in probing neuron-like dynamics. Frequency-domain analysis of artificial synapses yields essential insights into synaptic plasticity—the core mechanism of learning and memory—shaped by functions like retention and filtering. Memristor-based synapses display chemical inductor behavior, evident as a negative arc in impedance spectra, highlighting their complex dynamics. More broadly, IS is increasingly positioned not only as a diagnostic tool for material performance but also as a framework for designing systems governed by ion migration, accumulation, and relaxation. By capturing these processes, IS provides a powerful perspective for analyzing and engineering physical computation components.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"54 ","pages":"Article 101767"},"PeriodicalIF":6.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-08-28DOI: 10.1016/j.coelec.2025.101750
Vernalyn Abarintos, Andrew Piper, Arben Merkoci
Electrochemical lateral flow assays (eLFAs) have emerged as a promising alternative to traditional colorimetric LFAs, particularly for applications requiring quantitative readouts and improved sensitivity. Over the past two years, significant advancements have been made in eLFA design, fabrication, and analytical performance, positioning them as promising candidates for decentralized diagnostics and point-of-care (POC) testing. This review highlights recent advances in electrode integration techniques, redox-based signal amplification strategies, and the incorporation of wireless and battery-free electrochemical readout platforms. Multiplexed detection and real-time wireless data transmission have also been demonstrated, further increasing the utility of eLFAs in clinical and field settings. Additionally, innovative strategies to control contact pressure, optimize sample flow, and maintain device stability are being explored to improve reproducibility and usability. Despite these advancements, challenges remain, including biofouling, variability in sample matrices, and the need for standardized protocols across platforms.
{"title":"Electrochemical lateral flow assays: A new frontier for rapid and quantitative biosensing","authors":"Vernalyn Abarintos, Andrew Piper, Arben Merkoci","doi":"10.1016/j.coelec.2025.101750","DOIUrl":"10.1016/j.coelec.2025.101750","url":null,"abstract":"<div><div>Electrochemical lateral flow assays (eLFAs) have emerged as a promising alternative to traditional colorimetric LFAs, particularly for applications requiring quantitative readouts and improved sensitivity. Over the past two years, significant advancements have been made in eLFA design, fabrication, and analytical performance, positioning them as promising candidates for decentralized diagnostics and point-of-care (POC) testing. This review highlights recent advances in electrode integration techniques, redox-based signal amplification strategies, and the incorporation of wireless and battery-free electrochemical readout platforms. Multiplexed detection and real-time wireless data transmission have also been demonstrated, further increasing the utility of eLFAs in clinical and field settings. Additionally, innovative strategies to control contact pressure, optimize sample flow, and maintain device stability are being explored to improve reproducibility and usability. Despite these advancements, challenges remain, including biofouling, variability in sample matrices, and the need for standardized protocols across platforms.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"54 ","pages":"Article 101750"},"PeriodicalIF":6.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-25DOI: 10.1016/j.coelec.2025.101774
Alexander C. Reidell, Christopher T. LeBarron, Seyyedamirhossein Hosseini
Organic waste is one of the most diverse, abundant, and persistent types of pollutants, creating an urgent need for green and effective remediation strategies. Among various approaches, electrochemistry offers a unique opportunity, providing a flexible, scalable, efficient, and reagent-free method. Moreover, there is a strong correlation between the mechanistic understanding of organic waste degradation at the molecular level and the efficiency of the overall remediation process. Herein, we discuss major methods for remediating various types of halogenated organic waste and polymers, briefly explore the mechanistic insights behind each approach, and highlight key challenges and opportunities from a practical perspective.
{"title":"Electro-organic hydrodehalgenation of organic waste and their mechanistic understandings","authors":"Alexander C. Reidell, Christopher T. LeBarron, Seyyedamirhossein Hosseini","doi":"10.1016/j.coelec.2025.101774","DOIUrl":"10.1016/j.coelec.2025.101774","url":null,"abstract":"<div><div>Organic waste is one of the most diverse, abundant, and persistent types of pollutants, creating an urgent need for green and effective remediation strategies. Among various approaches, electrochemistry offers a unique opportunity, providing a flexible, scalable, efficient, and reagent-free method. Moreover, there is a strong correlation between the mechanistic understanding of organic waste degradation at the molecular level and the efficiency of the overall remediation process. Herein, we discuss major methods for remediating various types of halogenated organic waste and polymers, briefly explore the mechanistic insights behind each approach, and highlight key challenges and opportunities from a practical perspective.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"54 ","pages":"Article 101774"},"PeriodicalIF":6.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145516550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-01DOI: 10.1016/j.coelec.2025.101763
Ehsan Rahimi
Local nanoscale mapping of electrostatic surface potential (ESP) is advancing rapidly to meet the needs of electrochemistry and corrosion science. Conventional Kelvin probe force microscopy (KPFM), while valuable, is limited in liquid and dynamic redox environments due to restricted electrochemical control and spatial resolution. Recent advances in alternating current KPFM (AC-KPFM) and open-loop electric potential microscopy (OL-EPM) provide high-resolution, in-situ ESP imaging while suppressing parasitic Faradaic reactions. AC-KPFM is powerful for probing ionization and counterion interactions at solid–liquid interfaces, whereas OL-EPM enables visualization of corrosion initiation, nanoscale defects in coatings, and gradients across grain boundaries. Together, these methods bridge the gap between surface electrostatics and electrochemistry. Key challenges remain in temporal resolution, minimizing probe perturbations, and linking nanoscale data to macroscopic corrosion behavior. Nonetheless, these techniques reveal hidden electrochemical heterogeneities, clarify pathways of localized corrosion, and offer insights for designing durable, corrosion-resistant materials.
{"title":"Nanoscale corrosion analysis via in-situ surface potential mapping: Enhancing electrochemical insight with OL-EPM and AC-KPFM","authors":"Ehsan Rahimi","doi":"10.1016/j.coelec.2025.101763","DOIUrl":"10.1016/j.coelec.2025.101763","url":null,"abstract":"<div><div>Local nanoscale mapping of electrostatic surface potential (ESP) is advancing rapidly to meet the needs of electrochemistry and corrosion science. Conventional Kelvin probe force microscopy (KPFM), while valuable, is limited in liquid and dynamic redox environments due to restricted electrochemical control and spatial resolution. Recent advances in alternating current KPFM (AC-KPFM) and open-loop electric potential microscopy (OL-EPM) provide high-resolution, in-situ ESP imaging while suppressing parasitic Faradaic reactions. AC-KPFM is powerful for probing ionization and counterion interactions at solid–liquid interfaces, whereas OL-EPM enables visualization of corrosion initiation, nanoscale defects in coatings, and gradients across grain boundaries. Together, these methods bridge the gap between surface electrostatics and electrochemistry. Key challenges remain in temporal resolution, minimizing probe perturbations, and linking nanoscale data to macroscopic corrosion behavior. Nonetheless, these techniques reveal hidden electrochemical heterogeneities, clarify pathways of localized corrosion, and offer insights for designing durable, corrosion-resistant materials.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"54 ","pages":"Article 101763"},"PeriodicalIF":6.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Real-time, continuous in vivo molecular monitoring is crucial for advancing biomedical research and clinical healthcare, yet traditional methods face significant limitations. Electrochemical DNA-based (eDNA) biosensors are emerging as a powerful and highly versatile platform to address these needs. This review highlights key advancements within the last three years in eDNA biosensors tailored for in vivo continuous monitoring, emphasizing strategies to overcome challenges in stability, selectivity, and reversibility. Specifically, we delve into core eDNA biosensor designs and their in vivo applications, such as therapeutic drug monitoring, pharmacokinetic studies, real-time tracking of disease and neurochemical biomarkers, and feedback-controlled drug delivery. Furthermore, we critically examine significant progress in developing calibration-free operational strategies and ongoing efforts to tackle challenges related to long-term stability, receptor responsiveness, and target selectivity. The continued evolution of these platforms and their integration with artificial intelligence, positions eDNA biosensors as transformative tools for future biomedical breakthroughs and precision healthcare.
{"title":"Continuous monitoring of biomolecular targets in vivo using DNA-based electrochemical sensors","authors":"Alejandro Chamorro-Garcia , Myriam Alfonsini , Daniele Caprioli , Claudio Parolo , Andrea Idili","doi":"10.1016/j.coelec.2025.101765","DOIUrl":"10.1016/j.coelec.2025.101765","url":null,"abstract":"<div><div>Real-time, continuous <em>in vivo</em> molecular monitoring is crucial for advancing biomedical research and clinical healthcare, yet traditional methods face significant limitations. Electrochemical DNA-based (eDNA) biosensors are emerging as a powerful and highly versatile platform to address these needs. This review highlights key advancements within the last three years in eDNA biosensors tailored for <em>in vivo</em> continuous monitoring, emphasizing strategies to overcome challenges in stability, selectivity, and reversibility. Specifically, we delve into core eDNA biosensor designs and their <em>in vivo</em> applications, such as therapeutic drug monitoring, pharmacokinetic studies, real-time tracking of disease and neurochemical biomarkers, and feedback-controlled drug delivery. Furthermore, we critically examine significant progress in developing calibration-free operational strategies and ongoing efforts to tackle challenges related to long-term stability, receptor responsiveness, and target selectivity. The continued evolution of these platforms and their integration with artificial intelligence, positions eDNA biosensors as transformative tools for future biomedical breakthroughs and precision healthcare.</div></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"54 ","pages":"Article 101765"},"PeriodicalIF":6.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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