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Information bottleneck-based Hebbian learning rule naturally ties working memory and synaptic updates 基于信息瓶颈的希比学习规则将工作记忆和突触更新自然地联系在一起
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-05-16 DOI: 10.3389/fncom.2024.1240348
Kyle Daruwalla, Mikko Lipasti
Deep neural feedforward networks are effective models for a wide array of problems, but training and deploying such networks presents a significant energy cost. Spiking neural networks (SNNs), which are modeled after biologically realistic neurons, offer a potential solution when deployed correctly on neuromorphic computing hardware. Still, many applications train SNNs offline, and running network training directly on neuromorphic hardware is an ongoing research problem. The primary hurdle is that back-propagation, which makes training such artificial deep networks possible, is biologically implausible. Neuroscientists are uncertain about how the brain would propagate a precise error signal backward through a network of neurons. Recent progress addresses part of this question, e.g., the weight transport problem, but a complete solution remains intangible. In contrast, novel learning rules based on the information bottleneck (IB) train each layer of a network independently, circumventing the need to propagate errors across layers. Instead, propagation is implicit due the layers' feedforward connectivity. These rules take the form of a three-factor Hebbian update a global error signal modulates local synaptic updates within each layer. Unfortunately, the global signal for a given layer requires processing multiple samples concurrently, and the brain only sees a single sample at a time. We propose a new three-factor update rule where the global signal correctly captures information across samples via an auxiliary memory network. The auxiliary network can be trained a priori independently of the dataset being used with the primary network. We demonstrate comparable performance to baselines on image classification tasks. Interestingly, unlike back-propagation-like schemes where there is no link between learning and memory, our rule presents a direct connection between working memory and synaptic updates. To the best of our knowledge, this is the first rule to make this link explicit. We explore these implications in initial experiments examining the effect of memory capacity on learning performance. Moving forward, this work suggests an alternate view of learning where each layer balances memory-informed compression against task performance. This view naturally encompasses several key aspects of neural computation, including memory, efficiency, and locality.
深度神经前馈网络是解决各种问题的有效模型,但训练和部署此类网络需要耗费大量能源。尖峰神经网络(SNN)以生物现实神经元为模型,在神经形态计算硬件上正确部署后,可提供一种潜在的解决方案。尽管如此,许多应用仍然需要离线训练 SNN,而直接在神经形态硬件上运行网络训练是一个持续的研究问题。最主要的障碍是,反向传播技术虽然可以训练这种人工深度网络,但在生物学上是不可信的。神经科学家无法确定大脑如何通过神经元网络向后传播精确的错误信号。最近的研究进展解决了这一问题的一部分,例如权重传输问题,但完整的解决方案仍遥不可及。相比之下,基于信息瓶颈(IB)的新型学习规则能独立训练网络的每一层,从而避免了跨层传播误差的需要。相反,由于各层的前馈连接,传播是隐含的。这些规则采用三因素海比更新的形式,即全局误差信号调节各层的局部突触更新。遗憾的是,给定层的全局信号需要同时处理多个样本,而大脑每次只能看到一个样本。我们提出了一种新的三因素更新规则,即全局信号通过辅助记忆网络正确捕捉跨样本信息。辅助网络可以独立于主网络使用的数据集进行先验训练。在图像分类任务中,我们展示了与基线相当的性能。有趣的是,与学习和记忆之间没有联系的反向传播类似方案不同,我们的规则在工作记忆和突触更新之间建立了直接联系。据我们所知,这是第一个明确提出这种联系的规则。我们在最初的实验中探讨了记忆容量对学习成绩的影响。展望未来,这项工作提出了另一种学习观点,即各层在记忆信息压缩与任务执行之间取得平衡。这种观点自然包含了神经计算的几个关键方面,包括记忆、效率和定位。
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引用次数: 0
A machine learning approach to evaluate the impact of virtual balance/cognitive training on fall risk in older women 采用机器学习方法评估虚拟平衡/认知训练对老年妇女跌倒风险的影响
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-05-14 DOI: 10.3389/fncom.2024.1390208
Beata Sokołowska, Wiktor Świderski, Edyta Smolis-Bąk, Ewa Sokołowska, Teresa Sadura-Sieklucka
IntroductionNovel technologies based on virtual reality (VR) are creating attractive virtual environments with high ecological value, used both in basic/clinical neuroscience and modern medical practice. The study aimed to evaluate the effects of VR-based training in an elderly population.Materials and methodsThe study included 36 women over the age of 60, who were randomly divided into two groups subjected to balance-strength and balance-cognitive training. The research applied both conventional clinical tests, such as (a) the Timed Up and Go test, (b) the five-times sit-to-stand test, and (c) the posturographic exam with the Romberg test with eyes open and closed. Training in both groups was conducted for 10 sessions and embraced exercises on a bicycle ergometer and exercises using non-immersive VR created by the ActivLife platform. Machine learning methods with a k-nearest neighbors classifier, which are very effective and popular, were proposed to statistically evaluate the differences in training effects in the two groups.Results and conclusionThe study showed that training using VR brought beneficial improvement in clinical tests and changes in the pattern of posturographic trajectories were observed. An important finding of the research was a statistically significant reduction in the risk of falls in the study population. The use of virtual environments in exercise/training has great potential in promoting healthy aging and preventing balance loss and falls among seniors.
导言基于虚拟现实(VR)的新技术正在创造出具有高生态价值的迷人虚拟环境,这些技术在基础/临床神经科学和现代医疗实践中都得到了应用。该研究旨在评估基于虚拟现实技术的训练对老年人群的影响。研究对象包括 36 名 60 岁以上的女性,她们被随机分为两组,分别接受平衡-力量和平衡-认知训练。研究同时应用了传统的临床测试,如(a)定时起立行走测试;(b)五次坐立测试;以及(c)睁眼和闭眼后的罗伯格测试。两组的训练都进行了 10 次,包括在自行车测力计上进行的练习和使用 ActivLife 平台创建的非沉浸式 VR 进行的练习。研究提出了使用 k-nearest neighbors 分类器的机器学习方法,该方法非常有效且广受欢迎,用于统计评估两组训练效果的差异。研究的一个重要发现是,研究人群的跌倒风险在统计学上显著降低。在锻炼/训练中使用虚拟环境在促进健康老龄化、预防老年人平衡能力丧失和跌倒方面具有巨大潜力。
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引用次数: 0
Computational modeling to study the impact of changes in Nav1.8 sodium channel on neuropathic pain 通过计算建模研究 Nav1.8 钠通道的变化对神经性疼痛的影响
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-05-09 DOI: 10.3389/fncom.2024.1327986
Peter Kan, Yong Fang Zhu, Junling Ma, Gurmit Singh
ObjectiveNav1.8 expression is restricted to sensory neurons; it was hypothesized that aberrant expression and function of this channel at the site of injury contributed to pathological pain. However, the specific contributions of Nav1.8 to neuropathic pain are not as clear as its role in inflammatory pain. The aim of this study is to understand how Nav1.8 present in peripheral sensory neurons regulate neuronal excitability and induce various electrophysiological features on neuropathic pain.MethodsTo study the effect of changes in sodium channel Nav1.8 kinetics, Hodgkin–Huxley type conductance-based models of spiking neurons were constructed using the NEURON v8.2 simulation software. We constructed a single-compartment model of neuronal soma that contained Nav1.8 channels with the ionic mechanisms adapted from some existing small DRG neuron models. We then validated and compared the model with our experimental data from in vivo recordings on soma of small dorsal root ganglion (DRG) sensory neurons in animal models of neuropathic pain (NEP).ResultsWe show that Nav1.8 is an important parameter for the generation and maintenance of abnormal neuronal electrogenesis and hyperexcitability. The typical increased excitability seen is dominated by a left shift in the steady state of activation of this channel and is further modulated by this channel’s maximum conductance and steady state of inactivation. Therefore, modified action potential shape, decreased threshold, and increased repetitive firing of sensory neurons in our neuropathic animal models may be orchestrated by these modulations on Nav1.8.ConclusionComputational modeling is a novel strategy to understand the generation of chronic pain. In this study, we highlight that changes to the channel functions of Nav1.8 within the small DRG neuron may contribute to neuropathic pain.
目的 Nav1.8 的表达仅限于感觉神经元;据推测,该通道在损伤部位的异常表达和功能会导致病理性疼痛。然而,Nav1.8 对神经病理性疼痛的具体贡献并不像它在炎症性疼痛中的作用那样明确。为了研究钠通道 Nav1.8 动力学变化的影响,我们使用 NEURON v8.2 模拟软件构建了基于霍奇金-赫胥黎型电导的尖峰神经元模型。我们构建了一个包含 Nav1.8 通道的神经元体单室模型,其离子机制改编自现有的一些小型 DRG 神经元模型。结果我们发现,Nav1.8 是产生和维持神经元异常电生和过度兴奋的一个重要参数。典型的兴奋性增高主要是由于该通道激活稳态的左移,并进一步受到该通道最大电导和失活稳态的调节。因此,在我们的神经病理性动物模型中,动作电位形状的改变、阈值的降低和感觉神经元重复性发射的增加可能是由 Nav1.8 的这些调节作用协调的。在这项研究中,我们强调了小 DRG 神经元内 Nav1.8 通道功能的变化可能会导致神经病理性疼痛。
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引用次数: 0
Deep learning for automatic segmentation of vestibular schwannoma: a retrospective study from multi-center routine MRI 用于自动分割前庭分裂瘤的深度学习:一项来自多中心常规磁共振成像的回顾性研究
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-05-09 DOI: 10.3389/fncom.2024.1365727
Aaron Kujawa, Reuben Dorent, Steve Connor, Suki Thomson, Marina Ivory, Ali Vahedi, Emily Guilhem, Navodini Wijethilake, Robert Bradford, Neil Kitchen, Sotirios Bisdas, Sebastien Ourselin, Tom Vercauteren, Jonathan Shapey
Automatic segmentation of vestibular schwannoma (VS) from routine clinical MRI has potential to improve clinical workflow, facilitate treatment decisions, and assist patient management. Previous work demonstrated reliable automatic segmentation performance on datasets of standardized MRI images acquired for stereotactic surgery planning. However, diagnostic clinical datasets are generally more diverse and pose a larger challenge to automatic segmentation algorithms, especially when post-operative images are included. In this work, we show for the first time that automatic segmentation of VS on routine MRI datasets is also possible with high accuracy. We acquired and publicly release a curated multi-center routine clinical (MC-RC) dataset of 160 patients with a single sporadic VS. For each patient up to three longitudinal MRI exams with contrast-enhanced T1-weighted (ceT1w) (n = 124) and T2-weighted (T2w) (n = 363) images were included and the VS manually annotated. Segmentations were produced and verified in an iterative process: (1) initial segmentations by a specialized company; (2) review by one of three trained radiologists; and (3) validation by an expert team. Inter- and intra-observer reliability experiments were performed on a subset of the dataset. A state-of-the-art deep learning framework was used to train segmentation models for VS. Model performance was evaluated on a MC-RC hold-out testing set, another public VS datasets, and a partially public dataset. The generalizability and robustness of the VS deep learning segmentation models increased significantly when trained on the MC-RC dataset. Dice similarity coefficients (DSC) achieved by our model are comparable to those achieved by trained radiologists in the inter-observer experiment. On the MC-RC testing set, median DSCs were 86.2(9.5) for ceT1w, 89.4(7.0) for T2w, and 86.4(8.6) for combined ceT1w+T2w input images. On another public dataset acquired for Gamma Knife stereotactic radiosurgery our model achieved median DSCs of 95.3(2.9), 92.8(3.8), and 95.5(3.3), respectively. In contrast, models trained on the Gamma Knife dataset did not generalize well as illustrated by significant underperformance on the MC-RC routine MRI dataset, highlighting the importance of data variability in the development of robust VS segmentation models. The MC-RC dataset and all trained deep learning models were made available online.
从常规临床磁共振成像中自动分割前庭分裂瘤(VS)有望改善临床工作流程、促进治疗决策并协助患者管理。之前的工作表明,在为立体定向手术规划而获取的标准化磁共振成像数据集上,自动分割性能可靠。然而,临床诊断数据集通常更加多样化,对自动分割算法提出了更大的挑战,尤其是在包含术后图像的情况下。在这项工作中,我们首次展示了在常规磁共振成像数据集上自动分割 VS 的高准确性。我们获得并公开发布了一个由 160 名单个散发性 VS 患者组成的多中心常规临床(MC-RC)数据集。每位患者最多可接受三次纵向 MRI 检查,包括对比增强 T1 加权(ceT1w)(124 人)和 T2 加权(T2w)(363 人)图像,并对 VS 进行人工标注。分段的制作和验证是一个反复的过程:(1) 由一家专业公司进行初步分段;(2) 由三位训练有素的放射科医生之一进行审查;(3) 由一个专家组进行验证。在数据集的一个子集上进行了观察者之间和观察者内部的可靠性实验。最先进的深度学习框架用于训练 VS 的分割模型。在 MC-RC 暂缓测试集、另一个公开 VS 数据集和一个部分公开数据集上对模型性能进行了评估。在 MC-RC 数据集上训练的 VS 深度学习分割模型的泛化能力和鲁棒性显著提高。在观察者间实验中,我们的模型获得的骰子相似系数(DSC)与经过培训的放射科医生获得的相似系数相当。在 MC-RC 测试集中,ceT1w 的 DSC 中位数为 86.2(9.5),T2w 为 89.4(7.0),ceT1w+T2w 组合输入图像的 DSC 中位数为 86.4(8.6)。在为伽马刀立体定向放射外科手术获取的另一个公共数据集上,我们的模型分别获得了 95.3(2.9)、92.8(3.8) 和 95.5(3.3) 的中位 DSCs。相比之下,在伽马刀数据集上训练的模型并不能很好地泛化,在 MC-RC 常规 MRI 数据集上的表现就说明了这一点,这突出了数据可变性在开发稳健的 VS 分割模型中的重要性。MC-RC 数据集和所有经过训练的深度学习模型均可在线获取。
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引用次数: 0
PointAS: an attention based sampling neural network for visual perception PointAS:基于注意力的视觉感知采样神经网络
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-05-02 DOI: 10.3389/fncom.2024.1340019
Bozhi Qiu, Sheng Li, Lei Wang
Harnessing the remarkable ability of the human brain to recognize and process complex data is a significant challenge for researchers, particularly in the domain of point cloud classification—a technology that aims to replicate the neural structure of the brain for spatial recognition. The initial 3D point cloud data often suffers from noise, sparsity, and disorder, making accurate classification a formidable task, especially when extracting local information features. Therefore, in this study, we propose a novel attention-based end-to-end point cloud downsampling classification method, termed as PointAS, which is an experimental algorithm designed to be adaptable to various downstream tasks. PointAS consists of two primary modules: the adaptive sampling module and the attention module. Specifically, the attention module aggregates global features with the input point cloud data, while the adaptive module extracts local features. In the point cloud classification task, our method surpasses existing downsampling methods by a significant margin, allowing for more precise extraction of edge data points to capture overall contour features accurately. The classification accuracy of PointAS consistently exceeds 80% across various sampling ratios, with a remarkable accuracy of 75.37% even at ultra-high sampling ratios. Moreover, our method exhibits robustness in experiments, maintaining classification accuracies of 72.50% or higher under different noise disturbances. Both qualitative and quantitative experiments affirm the efficacy of our approach in the sampling classification task, providing researchers with a more accurate method to identify and classify neurons, synapses, and other structures, thereby promoting a deeper understanding of the nervous system.
利用人脑识别和处理复杂数据的非凡能力是研究人员面临的一项重大挑战,尤其是在点云分类领域--一种旨在复制大脑神经结构进行空间识别的技术。初始的三维点云数据往往存在噪声、稀疏性和无序性,这使得准确分类成为一项艰巨的任务,尤其是在提取局部信息特征时。因此,在本研究中,我们提出了一种新颖的基于注意力的端到端点云下采样分类方法,称为 PointAS,它是一种实验性算法,旨在适应各种下游任务。PointAS 由两个主要模块组成:自适应采样模块和注意力模块。具体来说,注意力模块将全局特征与输入的点云数据聚合在一起,而自适应模块则提取局部特征。在点云分类任务中,我们的方法大大超越了现有的下采样方法,可以更精确地提取边缘数据点,从而准确捕捉整体轮廓特征。在不同的采样率下,PointAS 的分类准确率始终保持在 80% 以上,即使在超高采样率下,准确率也高达 75.37%。此外,我们的方法在实验中表现出很强的鲁棒性,在不同的噪声干扰下都能保持 72.50% 或更高的分类准确率。定性和定量实验都肯定了我们的方法在采样分类任务中的功效,为研究人员识别和分类神经元、突触和其他结构提供了更准确的方法,从而促进了对神经系统的深入了解。
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引用次数: 0
Feedback stabilization of probabilistic finite state machines based on deep Q-network 基于深度 Q 网络的概率有限状态机反馈稳定化
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-05-02 DOI: 10.3389/fncom.2024.1385047
Hui Tian, Xin Su, Yanfang Hou
BackgroundAs an important mathematical model, the finite state machine (FSM) has been used in many fields, such as manufacturing system, health care, and so on. This paper analyzes the current development status of FSMs. It is pointed out that the traditional methods are often inconvenient for analysis and design, or encounter high computational complexity problems when studying FSMs.MethodThe deep Q-network (DQN) technique, which is a model-free optimization method, is introduced to solve the stabilization problem of probabilistic finite state machines (PFSMs). In order to better understand the technique, some preliminaries, including Markov decision process, ϵ-greedy strategy, DQN, and so on, are recalled.ResultsFirst, a necessary and sufficient stabilizability condition for PFSMs is derived. Next, the feedback stabilization problem of PFSMs is transformed into an optimization problem. Finally, by using the stabilizability condition and deep Q-network, an algorithm for solving the optimization problem (equivalently, computing a state feedback stabilizer) is provided.DiscussionCompared with the traditional Q learning, DQN avoids the limited capacity problem. So our method can deal with high-dimensional complex systems efficiently. The effectiveness of our method is further demonstrated through an illustrative example.
背景 作为一种重要的数学模型,有限状态机(FSM)已被广泛应用于制造系统、医疗保健等多个领域。本文分析了 FSM 的发展现状。方法介绍了一种无模型优化方法--深度 Q 网络(DQN)技术,用于解决概率有限状态机(PFSM)的稳定问题。为了更好地理解该技术,回顾了一些前言,包括马尔可夫决策过程、ϵ 贪婪策略、DQN 等。接着,将 PFSM 的反馈稳定问题转化为优化问题。讨论与传统的 Q 学习相比,DQN 避免了容量有限的问题。因此,我们的方法可以高效地处理高维复杂系统。我们通过一个示例进一步证明了我们方法的有效性。
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引用次数: 0
Prediction of Alzheimer's disease stages based on ResNet-Self-attention architecture with Bayesian optimization and best features selection 基于贝叶斯优化和最佳特征选择的 ResNet-自我关注架构的阿尔茨海默病分期预测
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-04-25 DOI: 10.3389/fncom.2024.1393849
Nabeela Yaqoob, Muhammad Attique Khan, Saleha Masood, Hussain Mobarak Albarakati, Ameer Hamza, Fatimah Alhayan, Leila Jamel, Anum Masood
Alzheimer's disease (AD) is a neurodegenerative illness that impairs cognition, function, and behavior by causing irreversible damage to multiple brain areas, including the hippocampus. The suffering of the patients and their family members will be lessened with an early diagnosis of AD. The automatic diagnosis technique is widely required due to the shortage of medical experts and eases the burden of medical staff. The automatic artificial intelligence (AI)-based computerized method can help experts achieve better diagnosis accuracy and precision rates. This study proposes a new automated framework for AD stage prediction based on the ResNet-Self architecture and Fuzzy Entropy-controlled Path-Finding Algorithm (FEcPFA). A data augmentation technique has been utilized to resolve the dataset imbalance issue. In the next step, we proposed a new deep-learning model based on the self-attention module. A ResNet-50 architecture is modified and connected with a self-attention block for important information extraction. The hyperparameters were optimized using Bayesian optimization (BO) and then utilized to train the model, which was subsequently employed for feature extraction. The self-attention extracted features were optimized using the proposed FEcPFA. The best features were selected using FEcPFA and passed to the machine learning classifiers for the final classification. The experimental process utilized a publicly available MRI dataset and achieved an improved accuracy of 99.9%. The results were compared with state-of-the-art (SOTA) techniques, demonstrating the improvement of the proposed framework in terms of accuracy and time efficiency.
阿尔茨海默病(AD)是一种神经退行性疾病,会对包括海马体在内的多个脑区造成不可逆转的损伤,从而损害认知、功能和行为。如果能及早诊断出老年痴呆症,就能减轻患者及其家人的痛苦。由于医学专家的短缺,自动诊断技术被广泛需要,同时也减轻了医务人员的负担。基于人工智能(AI)的计算机自动诊断方法可以帮助专家获得更好的诊断准确率和精确率。本研究基于 ResNet-Self 架构和模糊熵控制寻径算法(FEcPFA),提出了一种新的 AD 分期预测自动化框架。我们利用数据增强技术来解决数据集不平衡问题。下一步,我们提出了一种基于自我关注模块的新型深度学习模型。我们对 ResNet-50 架构进行了修改,并将其与用于重要信息提取的自我注意模块相连接。利用贝叶斯优化(BO)对超参数进行了优化,然后利用它来训练模型,随后利用它进行特征提取。利用提出的 FEcPFA 对自我关注提取的特征进行了优化。使用 FEcPFA 挑选出最佳特征,并传递给机器学习分类器进行最终分类。实验过程使用了公开的核磁共振数据集,准确率提高了 99.9%。实验结果与最先进的(SOTA)技术进行了比较,证明了拟议框架在准确性和时间效率方面的改进。
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引用次数: 0
Grid codes vs. multi-scale, multi-field place codes for space 网格代码与多尺度、多场空间位置代码的比较
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-04-19 DOI: 10.3389/fncom.2024.1276292
Robin Dietrich, Nicolai Waniek, Martin Stemmler, Alois Knoll
IntroductionRecent work on bats flying over long distances has revealed that single hippocampal cells have multiple place fields of different sizes. At the network level, a multi-scale, multi-field place cell code outperforms classical single-scale, single-field place codes, yet the performance boundaries of such a code remain an open question. In particular, it is unknown how general multi-field codes compare to a highly regular grid code, in which cells form distinct modules with different scales.MethodsIn this work, we address the coding properties of theoretical spatial coding models with rigorous analyses of comprehensive simulations. Starting from a multi-scale, multi-field network, we performed evolutionary optimization. The resulting multi-field networks sometimes retained the multi-scale property at the single-cell level but most often converged to a single scale, with all place fields in a given cell having the same size. We compared the results against a single-scale single-field code and a one-dimensional grid code, focusing on two main characteristics: the performance of the code itself and the dynamics of the network generating it.ResultsOur simulation experiments revealed that, under normal conditions, a regular grid code outperforms all other codes with respect to decoding accuracy, achieving a given precision with fewer neurons and fields. In contrast, multi-field codes are more robust against noise and lesions, such as random drop-out of neurons, given that the significantly higher number of fields provides redundancy. Contrary to our expectations, the network dynamics of all models, from the original multi-scale models before optimization to the multi-field models that resulted from optimization, did not maintain activity bumps at their original locations when a position-specific external input was removed.DiscussionOptimized multi-field codes appear to strike a compromise between a place code and a grid code that reflects a trade-off between accurate positional encoding and robustness. Surprisingly, the recurrent neural network models we implemented and optimized for either multi- or single-scale, multi-field codes did not intrinsically produce a persistent “memory” of attractor states. These models, therefore, were not continuous attractor networks.
导言:最近对长距离飞行的蝙蝠进行的研究发现,单个海马细胞具有多个不同大小的位置场。在网络水平上,多尺度、多场的位置细胞代码优于经典的单尺度、单场位置代码,但这种代码的性能边界仍是一个未决问题。特别是,一般的多场编码与高度规则的网格编码相比如何,我们还不得而知,在网格编码中,单元形成了不同尺度的不同模块。方法在这项工作中,我们通过对综合模拟的严格分析,解决了理论空间编码模型的编码特性问题。从多尺度、多场网络开始,我们进行了进化优化。由此产生的多场网络有时在单细胞水平上保留了多尺度特性,但最常见的情况是趋同于单一尺度,即给定细胞中的所有位置场都具有相同的大小。我们将结果与单尺度单字段代码和一维网格代码进行了比较,重点关注两个主要特征:代码本身的性能和生成代码的网络的动态。结果我们的模拟实验表明,在正常情况下,常规网格代码的解码精度优于所有其他代码,它能以较少的神经元和字段达到一定的精度。相比之下,多场编码对噪声和神经元随机脱落等病变具有更强的鲁棒性,因为场的数量大大增加提供了冗余。与我们的预期相反,从优化前的原始多尺度模型到优化后的多场模型,当特定位置的外部输入被移除时,所有模型的网络动力学都没有在其原始位置保持活动突起。令人惊讶的是,我们为多尺度或单尺度多场编码实现并优化的递归神经网络模型并没有从本质上产生持久的吸引子状态 "记忆"。因此,这些模型并非连续吸引子网络。
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引用次数: 0
Prediction of emotion distribution of images based on weighted K-nearest neighbor-attention mechanism 基于加权 K 近邻关注机制的图像情感分布预测
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-04-17 DOI: 10.3389/fncom.2024.1350916
Kai Cheng
Existing methods for classifying image emotions often overlook the subjective impact emotions evoke in observers, focusing primarily on emotion categories. However, this approach falls short in meeting practical needs as it neglects the nuanced emotional responses captured within an image. This study proposes a novel approach employing the weighted closest neighbor algorithm to predict the discrete distribution of emotion in abstract paintings. Initially, emotional features are extracted from the images and assigned varying K-values. Subsequently, an encoder-decoder architecture is utilized to derive sentiment features from abstract paintings, augmented by a pre-trained model to enhance classification model generalization and convergence speed. By incorporating a blank attention mechanism into the decoder and integrating it with the encoder's output sequence, the semantics of abstract painting images are learned, facilitating precise and sensible emotional understanding. Experimental results demonstrate that the classification algorithm, utilizing the attention mechanism, achieves a higher accuracy of 80.7% compared to current methods. This innovative approach successfully addresses the intricate challenge of discerning emotions in abstract paintings, underscoring the significance of considering subjective emotional responses in image classification. The integration of advanced techniques such as weighted closest neighbor algorithm and attention mechanisms holds promise for enhancing the comprehension and classification of emotional content in visual art.
现有的图像情绪分类方法往往忽视情绪对观察者的主观影响,而主要关注情绪类别。然而,这种方法忽略了图像中细微的情感反应,无法满足实际需要。本研究提出了一种采用加权近邻算法预测抽象绘画中情感离散分布的新方法。首先,从图像中提取情感特征并赋予不同的 K 值。随后,利用编码器-解码器架构从抽象绘画中提取情感特征,并通过预训练模型增强分类模型的泛化和收敛速度。通过在解码器中加入空白关注机制,并将其与编码器的输出序列相结合,可以学习抽象绘画图像的语义,从而促进精确、合理的情感理解。实验结果表明,与现有方法相比,利用注意力机制的分类算法的准确率高达 80.7%。这一创新方法成功地解决了辨别抽象画中情感这一复杂难题,强调了在图像分类中考虑主观情感反应的重要性。加权近邻算法和注意力机制等先进技术的整合有望提高对视觉艺术中情感内容的理解和分类。
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引用次数: 0
U-shaped convolutional transformer GAN with multi-resolution consistency loss for restoring brain functional time-series and dementia diagnosis 具有多分辨率一致性损失的 U 型卷积变换器 GAN 用于还原大脑功能时间序列和痴呆症诊断
IF 3.2 4区 医学 Q2 Neuroscience Pub Date : 2024-04-17 DOI: 10.3389/fncom.2024.1387004
Qiankun Zuo, Ruiheng Li, Binghua Shi, Jin Hong, Yanfei Zhu, Xuhang Chen, Yixian Wu, Jia Guo
IntroductionThe blood oxygen level-dependent (BOLD) signal derived from functional neuroimaging is commonly used in brain network analysis and dementia diagnosis. Missing the BOLD signal may lead to bad performance and misinterpretation of findings when analyzing neurological disease. Few studies have focused on the restoration of brain functional time-series data.MethodsIn this paper, a novel U-shaped convolutional transformer GAN (UCT-GAN) model is proposed to restore the missing brain functional time-series data. The proposed model leverages the power of generative adversarial networks (GANs) while incorporating a U-shaped architecture to effectively capture hierarchical features in the restoration process. Besides, the multi-level temporal-correlated attention and the convolutional sampling in the transformer-based generator are devised to capture the global and local temporal features for the missing time series and associate their long-range relationship with the other brain regions. Furthermore, by introducing multi-resolution consistency loss, the proposed model can promote the learning of diverse temporal patterns and maintain consistency across different temporal resolutions, thus effectively restoring complex brain functional dynamics.ResultsWe theoretically tested our model on the public Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, and our experiments demonstrate that the proposed model outperforms existing methods in terms of both quantitative metrics and qualitative assessments. The model's ability to preserve the underlying topological structure of the brain functional networks during restoration is a particularly notable achievement.ConclusionOverall, the proposed model offers a promising solution for restoring brain functional time-series and contributes to the advancement of neuroscience research by providing enhanced tools for disease analysis and interpretation.
导言从功能神经成像中获得的血氧水平依赖性(BOLD)信号常用于脑网络分析和痴呆诊断。在分析神经系统疾病时,BOLD 信号的缺失可能会导致不良表现和结果误读。本文提出了一种新型 U 形卷积变换器 GAN(UCT-GAN)模型,用于恢复缺失的脑功能时间序列数据。该模型充分利用了生成式对抗网络(GAN)的强大功能,同时结合了 U 型结构,从而在还原过程中有效捕捉分层特征。此外,基于变压器的生成器中还设计了多级时间相关注意和卷积采样,以捕捉缺失时间序列的全局和局部时间特征,并将其与其他脑区的长程关系联系起来。此外,通过引入多分辨率一致性损失,所提出的模型可以促进对不同时间模式的学习,并在不同时间分辨率之间保持一致性,从而有效地恢复复杂的大脑功能动态。结果我们在公开的阿尔茨海默病神经影像倡议(ADNI)数据集上对我们的模型进行了理论测试,实验证明所提出的模型在定量指标和定性评估方面都优于现有方法。总之,所提出的模型为恢复大脑功能时间序列提供了一种很有前景的解决方案,并通过为疾病分析和解释提供增强工具,为神经科学研究的进步做出了贡献。
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Frontiers in Computational Neuroscience
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