Pub Date : 2023-07-24DOI: 10.1109/TNB.2023.3298444
Subhash Chandra Pal;Dimitrios Toumpanakis;Johan Wikström;Chirag Kamal Ahuja;Robin Strand;Ashis Kumar Dhara
Segmentation of major brain vessels is very important for the diagnosis of cerebrovascular disorders and subsequent surgical planning. Vessel segmentation is an important preprocessing step for a wide range of algorithms for the automatic diagnosis or treatment of several vascular pathologies and as such, it is valuable to have a well-performing vascular segmentation pipeline. In this article, we propose an end-to-end multiscale residual dual attention deep neural network for resilient major brain vessel segmentation. In the proposed network, the encoder and decoder blocks of the U-Net are replaced with the multi-level atrous residual blocks to enhance the learning capability by increasing the receptive field to extract the various semantic coarse- and fine-grained features. Dual attention block is incorporated in the bottleneck to perform effective multiscale information fusion to obtain detailed structure of blood vessels. The methods were evaluated on the publicly available TubeTK data set. The proposed method outperforms the state-of-the-art techniques with dice of 0.79 on the whole-brain prediction. The statistical and visual assessments indicate that proposed network is robust to outliers and maintains higher consistency in vessel continuity than the traditional U-Net and its variations.
{"title":"Multi-Level Residual Dual Attention Network for Major Cerebral Arteries Segmentation in MRA Toward Diagnosis of Cerebrovascular Disorders","authors":"Subhash Chandra Pal;Dimitrios Toumpanakis;Johan Wikström;Chirag Kamal Ahuja;Robin Strand;Ashis Kumar Dhara","doi":"10.1109/TNB.2023.3298444","DOIUrl":"10.1109/TNB.2023.3298444","url":null,"abstract":"Segmentation of major brain vessels is very important for the diagnosis of cerebrovascular disorders and subsequent surgical planning. Vessel segmentation is an important preprocessing step for a wide range of algorithms for the automatic diagnosis or treatment of several vascular pathologies and as such, it is valuable to have a well-performing vascular segmentation pipeline. In this article, we propose an end-to-end multiscale residual dual attention deep neural network for resilient major brain vessel segmentation. In the proposed network, the encoder and decoder blocks of the U-Net are replaced with the multi-level atrous residual blocks to enhance the learning capability by increasing the receptive field to extract the various semantic coarse- and fine-grained features. Dual attention block is incorporated in the bottleneck to perform effective multiscale information fusion to obtain detailed structure of blood vessels. The methods were evaluated on the publicly available TubeTK data set. The proposed method outperforms the state-of-the-art techniques with dice of 0.79 on the whole-brain prediction. The statistical and visual assessments indicate that proposed network is robust to outliers and maintains higher consistency in vessel continuity than the traditional U-Net and its variations.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10242076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-11DOI: 10.1109/TNB.2023.3294330
J. Divya;S. Selvendran;A. Sivanantha Raja;Vamsi Borra
A dual-channel D-shaped photonic crystal fiber (PCF) based plasmonic sensor is proposed in this paper for the simultaneous detection of two different analytes using the surface plasmon resonance (SPR) technique. The sensor employs a 50 nm-thick layer of chemically stable gold on both cleaved surfaces of the PCF to induce the SPR effect. This configuration offers superior sensitivity and rapid response, making it highly effective for sensing applications. Numerical investigations are conducted using the finite element method (FEM). After optimizing the structural parameters, the sensor exhibits a maximum wavelength sensitivity of 10000 nm/RIU and an amplitude sensitivity of −216 RIU $^{-{1}}$ between the two channels. Additionally, each channel of the sensor exhibits its unique maximal wavelength and amplitude sensitivities for different refractive index (RI) ranges. Both channels demonstrate a maximal wavelength sensitivity of 6000 nm/RIU. In the RI range of 1.31-1.41, Channel 1 (Ch1) and Channel 2 (Ch2) achieved their maximum amplitude sensitivities of −85.39RIU $^{-{1}}$ and -304.52 RIU $^{-{1}}$ , respectively, with a resolution of ${5}times {10} ^{-{5}}$ . This sensor structure is noteworthy for its ability to measure both amplitude and wavelength sensitivity, providing enhanced performance characteristics suitable for various sensing purposes in chemical, biomedical, and industrial fields.
{"title":"A Novel Plasmonic Sensor Based on Dual-Channel D-Shaped Photonic Crystal Fiber for Enhanced Sensitivity in Simultaneous Detection of Different Analytes","authors":"J. Divya;S. Selvendran;A. Sivanantha Raja;Vamsi Borra","doi":"10.1109/TNB.2023.3294330","DOIUrl":"10.1109/TNB.2023.3294330","url":null,"abstract":"A dual-channel D-shaped photonic crystal fiber (PCF) based plasmonic sensor is proposed in this paper for the simultaneous detection of two different analytes using the surface plasmon resonance (SPR) technique. The sensor employs a 50 nm-thick layer of chemically stable gold on both cleaved surfaces of the PCF to induce the SPR effect. This configuration offers superior sensitivity and rapid response, making it highly effective for sensing applications. Numerical investigations are conducted using the finite element method (FEM). After optimizing the structural parameters, the sensor exhibits a maximum wavelength sensitivity of 10000 nm/RIU and an amplitude sensitivity of −216 RIU\u0000<inline-formula> <tex-math>$^{-{1}}$ </tex-math></inline-formula>\u0000 between the two channels. Additionally, each channel of the sensor exhibits its unique maximal wavelength and amplitude sensitivities for different refractive index (RI) ranges. Both channels demonstrate a maximal wavelength sensitivity of 6000 nm/RIU. In the RI range of 1.31-1.41, Channel 1 (Ch1) and Channel 2 (Ch2) achieved their maximum amplitude sensitivities of −85.39RIU\u0000<inline-formula> <tex-math>$^{-{1}}$ </tex-math></inline-formula>\u0000 and -304.52 RIU\u0000<inline-formula> <tex-math>$^{-{1}}$ </tex-math></inline-formula>\u0000, respectively, with a resolution of \u0000<inline-formula> <tex-math>${5}times {10} ^{-{5}}$ </tex-math></inline-formula>\u0000. This sensor structure is noteworthy for its ability to measure both amplitude and wavelength sensitivity, providing enhanced performance characteristics suitable for various sensing purposes in chemical, biomedical, and industrial fields.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10178050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9773117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.1109/TNB.2023.3289787
Hafezeh Nabipour;Sohrab Rohani
The current study developed a drug delivery system through the green chemistry-based synthesis of a biologically friendly metal-organic framework (bio-MOF) called Asp-Cu, which included copper ions and the environmentally friendly molecule L(+)-aspartic acid (Asp). For the first time, diclofenac sodium (DS) was loaded onto the synthesized bio-MOF simultaneously. The system’s efficiency was then improved by encapsulating it with sodium alginate (SA). FT-IR, SEM, BET, TGA, and XRD analyses confirmed that DS@Cu-ASP was successfully synthesized. DS@Asp-Cu was found to release the total load within 2 h when used with simulated stomach media. This challenge was overcome by coating DS@Cu-ASP with SA (SA@DS@Cu-ASP). SA@DS@Cu-ASP displayed limited drug release at pH 1.2, and a higher percentage of the drug was released at pH 6.8 and 7.4 due to the pH-responsive nature of SA. $Itextit {n vitro}$ cytotoxicity screening showed that SA@DS@Cu-ASP could be an appropriate biocompatible carrier with >90% cell viability. The on-command drug carrier was observed to be more applicable biocompatible with lower toxicity, as well as adequate loading properties and responsiveness, indicating its applicability as a feasible drug carrier with controlled release.
{"title":"Green Synthesis of pH-Responsive Metal–Organic Frameworks for Delivery of Diclofenac Sodium","authors":"Hafezeh Nabipour;Sohrab Rohani","doi":"10.1109/TNB.2023.3289787","DOIUrl":"10.1109/TNB.2023.3289787","url":null,"abstract":"The current study developed a drug delivery system through the green chemistry-based synthesis of a biologically friendly metal-organic framework (bio-MOF) called Asp-Cu, which included copper ions and the environmentally friendly molecule L(+)-aspartic acid (Asp). For the first time, diclofenac sodium (DS) was loaded onto the synthesized bio-MOF simultaneously. The system’s efficiency was then improved by encapsulating it with sodium alginate (SA). FT-IR, SEM, BET, TGA, and XRD analyses confirmed that DS@Cu-ASP was successfully synthesized. DS@Asp-Cu was found to release the total load within 2 h when used with simulated stomach media. This challenge was overcome by coating DS@Cu-ASP with SA (SA@DS@Cu-ASP). SA@DS@Cu-ASP displayed limited drug release at pH 1.2, and a higher percentage of the drug was released at pH 6.8 and 7.4 due to the pH-responsive nature of SA. \u0000<inline-formula> <tex-math>$Itextit {n vitro}$ </tex-math></inline-formula>\u0000 cytotoxicity screening showed that SA@DS@Cu-ASP could be an appropriate biocompatible carrier with >90% cell viability. The on-command drug carrier was observed to be more applicable biocompatible with lower toxicity, as well as adequate loading properties and responsiveness, indicating its applicability as a feasible drug carrier with controlled release.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.1109/TNB.2023.3290609
Sunil Kumar;Prabhat Kumar Sharma;Manav R. Bhatnagar
This work adopts a game theoretic approach to analyze the behavior of transmitter nanomachines (TNMs) in a diffusive 3-dimensional (3-D) channel. In order to communicate the local observations about the region of interest (RoI) to a common supervisor nanomachine (SNM), TNMs transmit information-carrying molecules to SNM. For the production of information-carrying molecules, all the TNMs share the common food molecular budget (CFMB). The TNMs apply cooperative and greedy strategic efforts to get their share from the CFMB. In the cooperative case, all the TNMs communicate to SNM as a group, therefore they cooperatively consume the CFMB to increase the group outcome, whereas, in the greedy scenario, all TNMs decide to perform alone and thus greedily consume the CFMB to increase their individual outcomes. The performance is evaluated in terms of the average rate of success, the average probability of error, and the receiver operating characteristic (ROC) of RoI detection. The derived results are verified through Monte-Carlo and particle-based simulations (PBS).
{"title":"Game-Theoretic Analysis of Fusion Rules Over Molecular Reporting Channels","authors":"Sunil Kumar;Prabhat Kumar Sharma;Manav R. Bhatnagar","doi":"10.1109/TNB.2023.3290609","DOIUrl":"10.1109/TNB.2023.3290609","url":null,"abstract":"This work adopts a game theoretic approach to analyze the behavior of transmitter nanomachines (TNMs) in a diffusive 3-dimensional (3-D) channel. In order to communicate the local observations about the region of interest (RoI) to a common supervisor nanomachine (SNM), TNMs transmit information-carrying molecules to SNM. For the production of information-carrying molecules, all the TNMs share the common food molecular budget (CFMB). The TNMs apply cooperative and greedy strategic efforts to get their share from the CFMB. In the cooperative case, all the TNMs communicate to SNM as a group, therefore they cooperatively consume the CFMB to increase the group outcome, whereas, in the greedy scenario, all TNMs decide to perform alone and thus greedily consume the CFMB to increase their individual outcomes. The performance is evaluated in terms of the average rate of success, the average probability of error, and the receiver operating characteristic (ROC) of RoI detection. The derived results are verified through Monte-Carlo and particle-based simulations (PBS).","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10135513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-04DOI: 10.1109/TNB.2023.3292131
Joana Angjo;Ali E. Pusane;H. Birkan Yilmaz;Ertugrul Basar;Tuna Tugcu
The actuation accuracy of sensing tasks performed by molecular communication (MC) schemes is a very important metric. Reducing the effect of sensors fallibility can be achieved by improvements and advancements in the sensor and communication networks design. Inspired by the technique of beamforming used extensively in radio frequency communication systems, a novel molecular beamforming design is proposed in this paper. This design can find application in tasks related to actuation of nano machines in MC networks. The main idea behind the proposed scheme is that the utilization of more sensing nano machines in a network can increase the overall accuracy of that network. In other words, the probability of an actuation error reduces as the number of sensors that collectively take the actuation decision increases. In order to achieve this, several design procedures are proposed. Three different scenarios for the observation of the actuation error are investigated. For each case, the analytical background is provided and compared with the results obtained by computer simulations. The improvement in the actuation accuracy by means of molecular beamforming is verified for a uniform linear array as well as for a random topology.
分子通信（MC）方案所执行的传感任务的执行精度是一个非常重要的指标。传感器和通信网络设计的改进和进步可以降低传感器易损性的影响。受射频通信系统中广泛使用的波束成形技术的启发，本文提出了一种新型分子波束成形设计。这种设计可应用于 MC 网络中与纳米机器驱动相关的任务。建议方案背后的主要理念是，在网络中利用更多的传感纳米机器可以提高该网络的整体精度。换句话说，随着共同做出执行决策的传感器数量增加，执行错误的概率也会降低。为此，我们提出了几种设计程序。本文研究了观察致动误差的三种不同情况。针对每种情况，都提供了分析背景，并与计算机模拟获得的结果进行了比较。对于均匀线性阵列和随机拓扑结构，通过分子波束成形技术提高致动精度的效果得到了验证。
{"title":"Molecular Beamforming for Actuation in Molecular Communication Networks","authors":"Joana Angjo;Ali E. Pusane;H. Birkan Yilmaz;Ertugrul Basar;Tuna Tugcu","doi":"10.1109/TNB.2023.3292131","DOIUrl":"10.1109/TNB.2023.3292131","url":null,"abstract":"The actuation accuracy of sensing tasks performed by molecular communication (MC) schemes is a very important metric. Reducing the effect of sensors fallibility can be achieved by improvements and advancements in the sensor and communication networks design. Inspired by the technique of beamforming used extensively in radio frequency communication systems, a novel molecular beamforming design is proposed in this paper. This design can find application in tasks related to actuation of nano machines in MC networks. The main idea behind the proposed scheme is that the utilization of more sensing nano machines in a network can increase the overall accuracy of that network. In other words, the probability of an actuation error reduces as the number of sensors that collectively take the actuation decision increases. In order to achieve this, several design procedures are proposed. Three different scenarios for the observation of the actuation error are investigated. For each case, the analytical background is provided and compared with the results obtained by computer simulations. The improvement in the actuation accuracy by means of molecular beamforming is verified for a uniform linear array as well as for a random topology.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The lifestyle of modern society is a major contributing factor for the majority of patients suffering from more than one disease. To Screen and diagnose each of those diseases, there is a great need for portable, and economical diagnostic tools, which are highly stipulated to yield rapid and accurate results using a small volume of the samples such as blood, saliva, sweat, etc. Point-of-care Testing (POCT) is one of the approaches to harvest prompt diagnosis of numerous diseases. The Majority of Point-of-Care Devices (POCD) are developed to diagnose one disease within the specimen. On the other hand, multi-disease detection capabilities in the same point-of-care devices are considered to be an efficient candidate to execute the state-of-the-art platform for multi-disease detection. Most of the literature reviews in this field focus on Point-of-Care (POC) devices, their underlying principles of operation, and their potential applications. It is evident from a perusal of the scholarly works that no review articles have been written on multi-disease detection POC devices. A review study analyzing the current level and functionality of multi-disease detection POC devices would be of great use to future researchers and device manufacturers. This review paper is addressing the above gap by focusing on various optical techniques like fluorescence, Absorbance, and Surface Plasmon Resonance (SPR) for multi-disease detection by harnessing the microfluidic-based POC device.
{"title":"Microfluidic Point-of-Care Diagnostics for Multi-Disease Detection Using Optical Techniques: A Review","authors":"Shaik Ahmadsaidulu;Oindrila Banik;Prasoon Kumar;Santosh Kumar;Earu Banoth","doi":"10.1109/TNB.2023.3291544","DOIUrl":"10.1109/TNB.2023.3291544","url":null,"abstract":"The lifestyle of modern society is a major contributing factor for the majority of patients suffering from more than one disease. To Screen and diagnose each of those diseases, there is a great need for portable, and economical diagnostic tools, which are highly stipulated to yield rapid and accurate results using a small volume of the samples such as blood, saliva, sweat, etc. Point-of-care Testing (POCT) is one of the approaches to harvest prompt diagnosis of numerous diseases. The Majority of Point-of-Care Devices (POCD) are developed to diagnose one disease within the specimen. On the other hand, multi-disease detection capabilities in the same point-of-care devices are considered to be an efficient candidate to execute the state-of-the-art platform for multi-disease detection. Most of the literature reviews in this field focus on Point-of-Care (POC) devices, their underlying principles of operation, and their potential applications. It is evident from a perusal of the scholarly works that no review articles have been written on multi-disease detection POC devices. A review study analyzing the current level and functionality of multi-disease detection POC devices would be of great use to future researchers and device manufacturers. This review paper is addressing the above gap by focusing on various optical techniques like fluorescence, Absorbance, and Surface Plasmon Resonance (SPR) for multi-disease detection by harnessing the microfluidic-based POC device.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-29DOI: 10.1109/TNB.2023.3283631
{"title":"IEEE Transactions on NanoBioscience Publication Information","authors":"","doi":"10.1109/TNB.2023.3283631","DOIUrl":"https://doi.org/10.1109/TNB.2023.3283631","url":null,"abstract":"","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/7728/10168529/10168672.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49907365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-29DOI: 10.1109/TNB.2023.3283635
{"title":"IEEE Transactions on NanoBioscience Information for Authors","authors":"","doi":"10.1109/TNB.2023.3283635","DOIUrl":"https://doi.org/10.1109/TNB.2023.3283635","url":null,"abstract":"","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/7728/10168529/10168305.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49907363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.1109/TNB.2023.3287805
Mohammad Reza Ahmadpour;Mahdi Yousefi;Hassan Rakhshandeh;Majid Darroudi;Seyed Hadi Mousavi;Mohammad Soukhtanloo;Zahra Sabouri;Vahid Reza Askari;Alireza Hashemzadeh;Mohammad Azad Manjiri;Malihe Motavasselian
In this study, gold nanoparticles (Au-NPs) were synthesized using HAuCl4 and quince seed mucilage (QSM) extract, which was characterized by conventional methods including Fourier transforms electron microscopy (FTIR), UV-Visible spectroscopy (UV-Vis), Field emission electron microscopy (FESEM), Transmission electron microscopy (TEM), Dynamic light spectroscopy (DLS), and Zeta-potential. The QSM acted as reductant and stabilizing agents simultaneously. The NP’s anticancer activity was also investigated against osteosarcoma cell lines (MG-63), which showed an IC50 of $317 mu text{g}$ /mL.
{"title":"Biosynthesis of Gold Nanoparticles Using Quince Seed Water Extract and Investigation of Their Anticancer Effect Against Cancer Cell Lines","authors":"Mohammad Reza Ahmadpour;Mahdi Yousefi;Hassan Rakhshandeh;Majid Darroudi;Seyed Hadi Mousavi;Mohammad Soukhtanloo;Zahra Sabouri;Vahid Reza Askari;Alireza Hashemzadeh;Mohammad Azad Manjiri;Malihe Motavasselian","doi":"10.1109/TNB.2023.3287805","DOIUrl":"10.1109/TNB.2023.3287805","url":null,"abstract":"In this study, gold nanoparticles (Au-NPs) were synthesized using HAuCl4 and quince seed mucilage (QSM) extract, which was characterized by conventional methods including Fourier transforms electron microscopy (FTIR), UV-Visible spectroscopy (UV-Vis), Field emission electron microscopy (FESEM), Transmission electron microscopy (TEM), Dynamic light spectroscopy (DLS), and Zeta-potential. The QSM acted as reductant and stabilizing agents simultaneously. The NP’s anticancer activity was also investigated against osteosarcoma cell lines (MG-63), which showed an IC50 of \u0000<inline-formula> <tex-math>$317 mu text{g}$ </tex-math></inline-formula>\u0000/mL.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9695453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-19DOI: 10.1109/TNB.2023.3287637
Martin Damrath;Mladen Veletić;Hamid Khoshfekr Rudsari;Ilangko Balasingham
Targeted drug delivery is a promising approach for many serious diseases, such as glioblastoma multiforme, one of the most common and devastating brain tumor. In this context, this work addresses the optimization of the controlled release of drugs which are carried by extracellular vesicles. Towards this goal, we derive and numerically verify an analytical solution for the end-to-end system model. We then apply the analytical solution either to reduce the disease treatment time or to reduce the amount of required drugs. The latter is formulated as a bilevel optimization problem, whose quasiconvex/quasiconcave property is proved here. For solving the optimization problem, we propose and utilize a combination of bisection method and golden-section search. The numerical results demonstrate that the optimization can significantly reduce the treatment time and/or the required drugs carried by extracellular vesicles for a therapy compared to the steady state solution.
{"title":"Optimization of Extracellular Vesicle Release for Targeted Drug Delivery","authors":"Martin Damrath;Mladen Veletić;Hamid Khoshfekr Rudsari;Ilangko Balasingham","doi":"10.1109/TNB.2023.3287637","DOIUrl":"10.1109/TNB.2023.3287637","url":null,"abstract":"Targeted drug delivery is a promising approach for many serious diseases, such as glioblastoma multiforme, one of the most common and devastating brain tumor. In this context, this work addresses the optimization of the controlled release of drugs which are carried by extracellular vesicles. Towards this goal, we derive and numerically verify an analytical solution for the end-to-end system model. We then apply the analytical solution either to reduce the disease treatment time or to reduce the amount of required drugs. The latter is formulated as a bilevel optimization problem, whose quasiconvex/quasiconcave property is proved here. For solving the optimization problem, we propose and utilize a combination of bisection method and golden-section search. The numerical results demonstrate that the optimization can significantly reduce the treatment time and/or the required drugs carried by extracellular vesicles for a therapy compared to the steady state solution.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9667345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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