Pub Date : 2019-01-01DOI: 10.20431/2349-0403.0602003
A. Singh, S. Verma, A. Dwivedi, O. P. Rai
Human health is closely linked with a healthy and clean environment. Rapid growth in urbanization and industrialization has increased the levels of heavy metals in the environment and consequently in the food chain. Metals ions play an important role in biological system 1-3 and required for many critical functions in human. Metal coordination to medicinally active molecules can be used to enhance their activity. The chemistry of metal-drug coordination compounds is more popular now than before particularly in the design of more biologically active drugs. 4 Many drugs posses modified pharmacological and toxicological properties when administered in the form of metallic complexes. The efficacies of the drug on coordination with a metal are enhanced in many cases. 5 Iron and Manganese are essential micronutrients with a variety of biochemical functions in all living organism. The amount of these metals can be varying in human body through intake of diet and different environmental factors, either contribute cause toxicity. 6 The present paper describes a paper electrophoretic method for the determination of stability constant of biologically significant metal complexes in solution. Stability constant is useful physical entity, which explains the importance and function of various complexes in biological systems. 7-9 High concentration of metal ions in living system can be prevented by the use of specific chelating agents. The chelation therapy for intoxication of metals depends upon the chelating agent being able to reach the intercellular site where the metals are firmly bound. For a pretty long time, varieties of ligand have been used as chelating agent to combat metal poisoning. In present study, ephedrine has been used as primary ligand, which is a sympathomimetic ammine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant and treat hypotension associated with anaesthesia. Literature survey 10-16 reveals that no work has been reported using ephedrine as a primary and NTA as a secondary ligand till now. This inspired us to study the stability constant of binary and mixed complexes of ephedrine and NTA with Fe (III) and Mn (II) in solution using paper electrophoretic technique. Abstract: Metals occur naturally in the earth’s crust and their contents in the environment can vary between different regions resulting in spatial variations of background concentrations. Human health is closely linked with a healthy and clean environment. Rapid growth in urbanization and industrialization has increased the levels of heavy metals in the environment and consequently in the food chain. Metal ions are required for many critical functions, physiological and pathological process in human. Iron and Manganese are essential micronutrients with a variety of biochemical functions in all living organism and their lethal dose become toxic to human body. High concentration of metal ions in living system can be prevented by the use of spe
{"title":"Electrophoretic Study of Binary and Mixed Metal Complexes with Medicinally Important Ligands","authors":"A. Singh, S. Verma, A. Dwivedi, O. P. Rai","doi":"10.20431/2349-0403.0602003","DOIUrl":"https://doi.org/10.20431/2349-0403.0602003","url":null,"abstract":"Human health is closely linked with a healthy and clean environment. Rapid growth in urbanization and industrialization has increased the levels of heavy metals in the environment and consequently in the food chain. Metals ions play an important role in biological system 1-3 and required for many critical functions in human. Metal coordination to medicinally active molecules can be used to enhance their activity. The chemistry of metal-drug coordination compounds is more popular now than before particularly in the design of more biologically active drugs. 4 Many drugs posses modified pharmacological and toxicological properties when administered in the form of metallic complexes. The efficacies of the drug on coordination with a metal are enhanced in many cases. 5 Iron and Manganese are essential micronutrients with a variety of biochemical functions in all living organism. The amount of these metals can be varying in human body through intake of diet and different environmental factors, either contribute cause toxicity. 6 The present paper describes a paper electrophoretic method for the determination of stability constant of biologically significant metal complexes in solution. Stability constant is useful physical entity, which explains the importance and function of various complexes in biological systems. 7-9 High concentration of metal ions in living system can be prevented by the use of specific chelating agents. The chelation therapy for intoxication of metals depends upon the chelating agent being able to reach the intercellular site where the metals are firmly bound. For a pretty long time, varieties of ligand have been used as chelating agent to combat metal poisoning. In present study, ephedrine has been used as primary ligand, which is a sympathomimetic ammine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant and treat hypotension associated with anaesthesia. Literature survey 10-16 reveals that no work has been reported using ephedrine as a primary and NTA as a secondary ligand till now. This inspired us to study the stability constant of binary and mixed complexes of ephedrine and NTA with Fe (III) and Mn (II) in solution using paper electrophoretic technique. Abstract: Metals occur naturally in the earth’s crust and their contents in the environment can vary between different regions resulting in spatial variations of background concentrations. Human health is closely linked with a healthy and clean environment. Rapid growth in urbanization and industrialization has increased the levels of heavy metals in the environment and consequently in the food chain. Metal ions are required for many critical functions, physiological and pathological process in human. Iron and Manganese are essential micronutrients with a variety of biochemical functions in all living organism and their lethal dose become toxic to human body. High concentration of metal ions in living system can be prevented by the use of spe","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80692091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-08DOI: 10.20431/2349-0403.0601001
S. Arasaretnam
The gelling and hardening reactions of tannin extracted from flower buds of Terminalia chebula with formaldehyde were analysed by parallel-plate rheometry techniques. In this study, a method to determine the rheological features of tannin-formaldehyde reactions both before and after the gel point was settled. The conversion from the liquid to solid state occurs at the gel point. Before the gel point, the zero shear viscosity can portray the behavior of the liquid resin. The value of this parameter rises as the polycondensation reaction proceeds, and at the gel point the weight average molecular mass turn into theoretically infinite.
{"title":"Study of Rheology of Tannin Obtained from Flower Buds of Terminalia chebula (Aralu) and Formaldehyde Reaction","authors":"S. Arasaretnam","doi":"10.20431/2349-0403.0601001","DOIUrl":"https://doi.org/10.20431/2349-0403.0601001","url":null,"abstract":"The gelling and hardening reactions of tannin extracted from flower buds of Terminalia chebula with formaldehyde were analysed by parallel-plate rheometry techniques. In this study, a method to determine the rheological features of tannin-formaldehyde reactions both before and after the gel point was settled. The conversion from the liquid to solid state occurs at the gel point. Before the gel point, the zero shear viscosity can portray the behavior of the liquid resin. The value of this parameter rises as the polycondensation reaction proceeds, and at the gel point the weight average molecular mass turn into theoretically infinite.","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74270251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.20431/2349-0403.0508005
Mohammad Nassar, Khalid A M Attia, A. A. Mohamad, Ragab A. M. Said, R. F. A. Gaber
Combination of ALP and BENZ has the advantages of greater therapeutic effect than with either drug alone. This combination causes manifold reduction in uric acid concentrations in plasma and urine as compared to double dose of the individual drug when used alone. Also, this combination helps to decrease the dose of each active ingredient, and as a result, decreases the side effects of each of component if given separately in high doses. (3)
{"title":"UV Spectrophotometric Determination of Allopurinol and Benzbromarone in their Binary Mixture using Artificial Neural Networks and Genetic Algorithm- Artificial Neural Networks","authors":"Mohammad Nassar, Khalid A M Attia, A. A. Mohamad, Ragab A. M. Said, R. F. A. Gaber","doi":"10.20431/2349-0403.0508005","DOIUrl":"https://doi.org/10.20431/2349-0403.0508005","url":null,"abstract":"Combination of ALP and BENZ has the advantages of greater therapeutic effect than with either drug alone. This combination causes manifold reduction in uric acid concentrations in plasma and urine as compared to double dose of the individual drug when used alone. Also, this combination helps to decrease the dose of each active ingredient, and as a result, decreases the side effects of each of component if given separately in high doses. (3)","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"1136 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74142939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.20431/2349-0403.0502002
B. Pandey, S. Nigam, S. S. Paihar, A. Prasad
Hibiscus a genus of flowering plants in malvaceae family contains 100 species that are native to warm grown in subtropical and tropical regions throughout India. It includes both woody shrubs and small trees. The flowers are large and of red and white colours. It is typically found almost everywhere. The red Hibiscus is the flower of the Hindu goddess Kali in Bengal India and offered goddess and Lord Ganesha in Hindu worship.
{"title":"Chemical Analysis of Hibiscus Rosa Sinenses-L","authors":"B. Pandey, S. Nigam, S. S. Paihar, A. Prasad","doi":"10.20431/2349-0403.0502002","DOIUrl":"https://doi.org/10.20431/2349-0403.0502002","url":null,"abstract":"Hibiscus a genus of flowering plants in malvaceae family contains 100 species that are native to warm grown in subtropical and tropical regions throughout India. It includes both woody shrubs and small trees. The flowers are large and of red and white colours. It is typically found almost everywhere. The red Hibiscus is the flower of the Hindu goddess Kali in Bengal India and offered goddess and Lord Ganesha in Hindu worship.","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"26 7","pages":"6-8"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72605397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.20431/2349-0403.0508003
S. Joshi, P. Thapa
Rhododendrons are of the genus Rhododendron that belonging to the family Ericaceae. It is represented by about 1025 species in the world, mostly concentrated in the Himalayan region of Nepal, and the temperate regions of Northern hemisphere especially in Sino-Himalayas (Eastern Himalayas and Western China). Besides this main centre, the Rhododendrons have further proliferated towards southern and northeastern China, Japan, Myanmar, Thailand, Malaysia, Indonesia, Philippines and New Guinea. A few species are also reported from Afghanistan, Australia Pakistan, southern parts of Europe and northern parts of America [1]. In Nepal, this genus comprises 32 species most of these are distributed at the altitude ranging from 1500-5000m.This genus has long been used as folk medicine in Nepal and other countries of the world. A few members of this genus such as R. ponticum and R. lustem contained grayanine type tetracyclic diterpenes which are known to be toxic to common livestock such as cattle. But a large members of this genus contained bioactive chemical constituents such as essential oils, ursolic acid, oleanolic acids, phenol, coumarins, flavonoids, etc these are important for human being [2].
{"title":"Chemical Composition and Antioxidant Activity of Rhododendron lepidotum Wall. ex D. Don, Essential Oil from Nepal","authors":"S. Joshi, P. Thapa","doi":"10.20431/2349-0403.0508003","DOIUrl":"https://doi.org/10.20431/2349-0403.0508003","url":null,"abstract":"Rhododendrons are of the genus Rhododendron that belonging to the family Ericaceae. It is represented by about 1025 species in the world, mostly concentrated in the Himalayan region of Nepal, and the temperate regions of Northern hemisphere especially in Sino-Himalayas (Eastern Himalayas and Western China). Besides this main centre, the Rhododendrons have further proliferated towards southern and northeastern China, Japan, Myanmar, Thailand, Malaysia, Indonesia, Philippines and New Guinea. A few species are also reported from Afghanistan, Australia Pakistan, southern parts of Europe and northern parts of America [1]. In Nepal, this genus comprises 32 species most of these are distributed at the altitude ranging from 1500-5000m.This genus has long been used as folk medicine in Nepal and other countries of the world. A few members of this genus such as R. ponticum and R. lustem contained grayanine type tetracyclic diterpenes which are known to be toxic to common livestock such as cattle. But a large members of this genus contained bioactive chemical constituents such as essential oils, ursolic acid, oleanolic acids, phenol, coumarins, flavonoids, etc these are important for human being [2].","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"18 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84889981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.20431/2349-0403.0502001
Jeetnarayan Chaturvedi, M. U. Khan, S. Sachan, A. Dwivedi
The recent advancements in medicinal chemistry not only revolutionized in traditional practice in allopathic system but in Ayurvedic generic life medicines too. The purified chemical derivatives of herbs like extracts, fractionates, and isolates are being preferred which are medicinally better than other synthetic drugs. During the last few decades, the advance studies of natural products has been tremendously was a field of research in chemistry, material science as well as life science. Natural products have come from various source material including terrestrial plants, from plant kingdom.
{"title":"Electrochemical Medicinal Analysis of Bhumi Amla","authors":"Jeetnarayan Chaturvedi, M. U. Khan, S. Sachan, A. Dwivedi","doi":"10.20431/2349-0403.0502001","DOIUrl":"https://doi.org/10.20431/2349-0403.0502001","url":null,"abstract":"The recent advancements in medicinal chemistry not only revolutionized in traditional practice in allopathic system but in Ayurvedic generic life medicines too. The purified chemical derivatives of herbs like extracts, fractionates, and isolates are being preferred which are medicinally better than other synthetic drugs. During the last few decades, the advance studies of natural products has been tremendously was a field of research in chemistry, material science as well as life science. Natural products have come from various source material including terrestrial plants, from plant kingdom.","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"108 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87666714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.20431/2349-0403.0502003
S. Mishra, M. Swami, N. Manikpuri, A. Dwivedi
The mandelic acid and Þ-chloromandelic acid are bifunctional compounds contain hydroxyl (–OH) and carboxylic group (–COOH), exhibiting different kinds of reactions when attached by the oxidants. A lot of works on the kinetics and oxidation of mandelic acid and p-substituted mandelic acid by various oxidants like halogens ,[1] NBS [2] , CAB [3] , KMnO4, [4] H2CrO4, [5] K2Cr2O7 [6] , NCSA [7] have been extensively carried out by many eminent authors.
{"title":"Nicotinium Dichromate Oxidation of Mandelic Acid and P-Chloromandelic Acid","authors":"S. Mishra, M. Swami, N. Manikpuri, A. Dwivedi","doi":"10.20431/2349-0403.0502003","DOIUrl":"https://doi.org/10.20431/2349-0403.0502003","url":null,"abstract":"The mandelic acid and Þ-chloromandelic acid are bifunctional compounds contain hydroxyl (–OH) and carboxylic group (–COOH), exhibiting different kinds of reactions when attached by the oxidants. A lot of works on the kinetics and oxidation of mandelic acid and p-substituted mandelic acid by various oxidants like halogens ,[1] NBS [2] , CAB [3] , KMnO4, [4] H2CrO4, [5] K2Cr2O7 [6] , NCSA [7] have been extensively carried out by many eminent authors.","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"35 1","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87991948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.20431/2349-0403.0503004
S. Shrestha
Schiff bases are typically formed by the condensation of a primary amine andan aldehyde/ketone. The resultant compound, R1R2C=NR3, is called a Schiff base(named after Hugo Schiff), where R1 is an aryl group, R2 is a hydrogen atom and R3is either an alkyl or aryl group. Schiff bases are generally bidentate (1), tridentate (2), tetradentate (3) orpolydentate (4) ligands capable of forming very stable complexes with transitionmetals. They can only act as coordinating ligands if they bear a functional group,usually the hydroxyl, sufficiently near the site of condensation in such a way that afive or six membered ring can be formed when reacting with a metal ion (Fig. 1.).
{"title":"Synthesis and Characterization of Oxovanadium (Iv) Complexes and Metal (Ii) Schiff Base Complexes","authors":"S. Shrestha","doi":"10.20431/2349-0403.0503004","DOIUrl":"https://doi.org/10.20431/2349-0403.0503004","url":null,"abstract":"Schiff bases are typically formed by the condensation of a primary amine andan aldehyde/ketone. The resultant compound, R1R2C=NR3, is called a Schiff base(named after Hugo Schiff), where R1 is an aryl group, R2 is a hydrogen atom and R3is either an alkyl or aryl group. Schiff bases are generally bidentate (1), tridentate (2), tetradentate (3) orpolydentate (4) ligands capable of forming very stable complexes with transitionmetals. They can only act as coordinating ligands if they bear a functional group,usually the hydroxyl, sufficiently near the site of condensation in such a way that afive or six membered ring can be formed when reacting with a metal ion (Fig. 1.).","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"128 1","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83729468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.20431/2349-0403.0506005
D. S. Kulkarni, A. Mishra, S. Patil, Kiran Uphale
The development in technology and industrial activities has lead to release of various metal ions to the environment. The present study aims to assess the efficiency of Rice Husk in treating chromium (VI) from simulated wastewater, with the help of fixed-bed adsorption column by performing continuous adsorption experiment. The results obtained through this study were confirmed by developing a model. A detailed analysis on the effects of extensive parameters on the adsorption experiment was done. The extensive parameters considered were Concentration, Flow-rate, and Bed-height. It was observed that as flowrate decreased from 60 ml/min to 30ml/min, the breakthrough time also decreased from 30 to 20 min. whereas as when the concentration was increased from 250 mg/L to 1000 mg/, the breakthrough time came down to 10 min fro m 40 min. The parameters which were calculated were total percentage removal of Cr (VI) and breakthrough time. It was observed that the exhaustion time decreases with increase in the concentration and flow rate and it increases with bed height. The data obtained during the entire experiment were fitted in Thomas and Yoon Nelson Model. The values of the model parameters were evaluated and analyzed.
{"title":"Modeling of Breakthrough Curves for Removal of Chromium from Waste Water","authors":"D. S. Kulkarni, A. Mishra, S. Patil, Kiran Uphale","doi":"10.20431/2349-0403.0506005","DOIUrl":"https://doi.org/10.20431/2349-0403.0506005","url":null,"abstract":"The development in technology and industrial activities has lead to release of various metal ions to the environment. The present study aims to assess the efficiency of Rice Husk in treating chromium (VI) from simulated wastewater, with the help of fixed-bed adsorption column by performing continuous adsorption experiment. The results obtained through this study were confirmed by developing a model. A detailed analysis on the effects of extensive parameters on the adsorption experiment was done. The extensive parameters considered were Concentration, Flow-rate, and Bed-height. It was observed that as flowrate decreased from 60 ml/min to 30ml/min, the breakthrough time also decreased from 30 to 20 min. whereas as when the concentration was increased from 250 mg/L to 1000 mg/, the breakthrough time came down to 10 min fro m 40 min. The parameters which were calculated were total percentage removal of Cr (VI) and breakthrough time. It was observed that the exhaustion time decreases with increase in the concentration and flow rate and it increases with bed height. The data obtained during the entire experiment were fitted in Thomas and Yoon Nelson Model. The values of the model parameters were evaluated and analyzed.","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"14 1","pages":"29-40"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74416417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.20431/2349-0403.0503002
S. Neeraj, S. S. Parihar, A. Dwivedi
1,3-dichloro-5,5-dimethylhydantoin (DCDMH) belongs to the class of N-halo compounds and is a moderate oxidant. The final hydrolysis of this compound leads to the formation of active positive halogen species like HOCl and H2O + Cl. The H2O + Cl manifests more in non-polar or less polar media, extensively used as a chlorinating and oxidizing agents in organic substrates. The generated species are utilized in solution and gaining importance in organic synthesis and also in analytical determination of organic compounds. 1,2 Since the N-halooxidants exhibit appreciable stability both in acid and alkaline medium 3,4 hence widely used in kinetic studies. Biological production of hypochlorous acid (HOCl) is also reported during activation of ecosinophilis. The H2O + Cl and HOCl thus produced kill the invading pathogens and also play an important role in damaging the tissues. It was also concluded that alphaaminoacids namely l-Alanine and l-Glycine are the major biological compounds 5 reacting with the H2O + Cl.
{"title":"Study of Oxidation of Some Alpha Amino Acids by 1, 3-Dichloro-5, 5-Dimethylhydantoin in Aqueous Acetic Acid Medium","authors":"S. Neeraj, S. S. Parihar, A. Dwivedi","doi":"10.20431/2349-0403.0503002","DOIUrl":"https://doi.org/10.20431/2349-0403.0503002","url":null,"abstract":"1,3-dichloro-5,5-dimethylhydantoin (DCDMH) belongs to the class of N-halo compounds and is a moderate oxidant. The final hydrolysis of this compound leads to the formation of active positive halogen species like HOCl and H2O + Cl. The H2O + Cl manifests more in non-polar or less polar media, extensively used as a chlorinating and oxidizing agents in organic substrates. The generated species are utilized in solution and gaining importance in organic synthesis and also in analytical determination of organic compounds. 1,2 Since the N-halooxidants exhibit appreciable stability both in acid and alkaline medium 3,4 hence widely used in kinetic studies. Biological production of hypochlorous acid (HOCl) is also reported during activation of ecosinophilis. The H2O + Cl and HOCl thus produced kill the invading pathogens and also play an important role in damaging the tissues. It was also concluded that alphaaminoacids namely l-Alanine and l-Glycine are the major biological compounds 5 reacting with the H2O + Cl.","PeriodicalId":13721,"journal":{"name":"International Journal of Advanced Research in Chemical Science","volume":"40 1","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89643904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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