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MOLECULAR CHARACTERIZATION OF ADENOVIRUS AND ROTAVIRUS ASSOCIATED DIARRHOEA AMONG UNDER-FIVES IN TWO TERTIARY HOSPITALS IN SOUTHERN NIGERIA 尼日利亚南部两家三甲医院五岁以下儿童与腺病毒和轮状病毒相关腹泻的分子特征描述
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18290
Dirisu John Osilumie, Agbakoba Nneka Regina, Okwelogu Somadina Izunna, Eki-Udoko Fidelis E., E. Jacinta C., O. Olukayode
Background: Viral diarrhoea continues to be a challenge among children under five years of age in Nigeria. While other non-viral agents of diarrhoea have been well documented, the agents of viral diarrhoea especially their genetic diversity have not been well studied in our locality, hence this study. Method: This was a cross-sectional study carried out at the University of Benin Teaching Hospital (UBTH) and NnamdiAzikiwe University Teaching Hospital (NAUTH) in Benin City and Nnewi respectively. Three hundred and thirty participants were recruited for the study using stratified random sampling, aged between 1 and 5 years. All the diarrhoeic stools had their DNA/RNA extracted using the Quick-RNA Viral MiniPrep Kit and stored at -80°C for polymerase chain reaction. Sequences of the adenovirus were done using a Big Dye DNA sequencing kit. Bioinformatics was done using R packages in R studio v3 software. Data from the study were analyzed using chi-square and level of significance expressed using p-value (p<0.05). Results: Adenoviral diarrhoea was higher in Benin City (18 11.8%) than Nnewi (11 6.1%). Females (55.2%) were more infected than the males (44.8%) (p>0.05). Among the population studied, there was no rotavirus genome detected. Ten (10) adenovirus sequences from serotype 40 were identified and deposited into the National Centre for Biotechnology Information (Genbank: http://www.ncbi.nlm.nih.gov/) under the accession number ON128719 - ON128728. The prevalence of adenovirus in the study locality is 8.7%. More females were infected than the males, although not statistically significant (p>0.05). Conclusion: The study also concluded that sex had no relationship with the spread of adenovirus diarrhoea among under-fives (p>0.05).
背景:病毒性腹泻仍然是尼日利亚五岁以下儿童面临的一项挑战。虽然其他非病毒性腹泻病原体已被很好地记录下来,但病毒性腹泻病原体,尤其是其遗传多样性在我们当地还没有得到很好的研究,因此才有了这项研究。研究方法这是一项横断面研究,分别在贝宁市的贝宁大学教学医院(UBTH)和恩纳迪-阿齐基韦大学教学医院(NAUTH)进行。研究采用分层随机抽样法,共招募了 330 名年龄在 1 至 5 岁之间的参与者。所有腹泻粪便均使用 Quick-RNA Viral MiniPrep Kit 提取了 DNA/RNA,并保存在 -80°C 温度下进行聚合酶链反应。腺病毒的序列用 Big Dye DNA 测序试剂盒完成。生物信息学使用 R studio v3 软件中的 R 软件包完成。研究数据使用卡方进行分析,显著性水平使用 p 值(p0.05)表示。在所研究的人群中,没有检测到轮状病毒基因组。已鉴定出 10 个来自血清型 40 的腺病毒序列,并将其存入美国国家生物技术信息中心(Genbank:http://www.ncbi.nlm.nih.gov/),登录号为 ON128719 - ON128728。研究地区的腺病毒感染率为 8.7%。受感染的女性多于男性,但没有统计学意义(P>0.05)。结论研究还得出结论,性别与腺病毒腹泻在五岁以下儿童中的传播没有关系(P>0.05)。
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引用次数: 0
PREFERENCE OF INVESTORS TOWARDS POST OFFICE SAVING SCHEMES 投资者对邮局储蓄计划的偏好
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18310
Harsha Sirmour, R.P Agrawal
Background/Purpose:Post office saving schemes are backed by the government of the respective country, providing a high level of safety and security for investors funds.Some post office saving schemes may offer tax benefits, such as exemptions on the interest earned or deductions under specific sections of the tax code. Post office saving schemes, such as fixed deposits or recurring deposits, can be suitable for individuals with long-term savings goals, such as planning for education, marriage, or retirement.It is essential for investors to carefully evaluate their financial objectives and consider factors like inflation, liquidity needs, and overall portfolio diversification before choosing post office saving schemes as their primary investment avenue. Objective: To analyze the preference of investors towards different post office saving schemes. Design/Methodology/Approach: Primary data is collected through a structured questionnaire. The area of research is confined to Durg district only. Descriptive analysis has been done to analyze the research questions. Originality/Value: This paper outlines the perception of an individual towards the different saving schemes provided by the Post office. Findings/Results:An investment is a pledge of a persons current assets that allows him to receive future income through interest, dividends, rent, wages, pension benefits, or capital appreciation.
背景/目的:邮局储蓄计划由相关国家的政府提供支持,为投资者的资金提供高度的安全保障。邮局储蓄计划,如定期存款或经常性存款,适合有长期储蓄目标的个人,如教育、婚姻或退休计划。投资者在选择邮局储蓄计划作为主要投资渠道之前,必须仔细评估自己的财务目标,并考虑通货膨胀、流动性需求和整体投资组合多样化等因素。目的分析投资者对不同邮局储蓄计划的偏好。设计/方法/途径:通过结构化问卷收集原始数据。研究范围仅限于杜尔格地区。对研究问题进行了描述性分析。原创性/价值:本文概述了个人对邮局提供的不同储蓄计划的看法。研究结果/成果:投资是对个人流动资产的抵押,使其能够通过利息、股息、租金、工资、养老金福利或资本增值获得未来收入。
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引用次数: 0
STREAMLINED SYNTHESIS: ENHANCING THE LEIMGRUBER-BATCHO INDOLE ROUTE FOR ONE-POT TANDEM PRODUCTION OF 2,3-UNSUBSTITUTED INDOLES 简化合成:改进莱姆格鲁伯-批次吲哚路线,实现 2,3- 未取代吲哚的一锅串联生产
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18325
Aviraboina Siva Prasad, Talupula Venkateswara Rao
Aim:This study aims to create a new one-pot synthesis method for substituted indoles, focusing on efficiency, by-product reduction, and comparative advantages over conventional Leimgruber-Batcho reactions. Methods:Researchers optimized a one-pot synthesis strategy for maximum yield, reduced by-products, and resource utilization, comparing it to traditional Leimgruber-Batcho reactions, ensuring a sustainable, environmentally friendly approach. Results:The one-pot synthesis method efficiently produced substituted indoles with reduced environmental impact, yielding more than conventional reactions, shortened reaction times, and aligning with green chemistry principles. Conclusions:The one-pot synthesis method for substituted indoles, using 2-nitrotoluenes and dimethylformamide dimethyl acetal, is a significant advancement in the field, offering improved efficiency, environmental sustainability, and higher yields compared to conventional methods, making it a more resource-effective and economically viable option.
目的:本研究旨在创建一种新的取代吲哚的单锅合成方法,重点关注效率、副产物的减少以及与传统的莱姆格鲁伯-巴乔反应相比的比较优势。方法:研究人员优化了单锅合成策略,使其与传统的莱姆格鲁伯-巴乔反应相比,产量最大化、副产物减少、资源利用率提高,确保了可持续的环保方法。结果:单锅合成法有效地生产了取代吲哚,减少了对环境的影响,收率高于传统反应,缩短了反应时间,符合绿色化学原则。结论:使用 2-硝基甲苯和二甲基甲酰胺二甲基缩醛进行取代吲哚的单锅合成方法是该领域的一大进步,与传统方法相比,该方法具有更高的效率、环境可持续性和更高的产率,是一种更具资源效益和经济可行性的选择。
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引用次数: 0
RISE OF E-SPORTS AND GAMING: BALANCING SCREEN TIME WITH PHYSICAL ACTIVITY 电子竞技和游戏的兴起:平衡屏幕时间与体育活动
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18358
Rahul Dev Choudhury, Sukanta Ch Nath, Debraj Nath, K. Hinoca Assumi
The brief overview highlighted the evolving realm of e-sports and gaming, emphasizing the ascent of competitive play, its effect on health and wellbeing, and the necessity to adapt public strategies to the digital arena. It examined the growth of e-sports, the issues linked to extended screen time, and the value of promoting physical exercise among gamers. The summary underscored movements and predictions in e-sports, such as continuing expansion, mainstream acceptance, diversification of titles, mobile gaming prominence, increased professionalism, integration of emerging technologies, and regional spread. Furthermore, it explored ways to adapt public health initiatives to the digital space, like digital health promotion, online psychological help, digital literacy and health education, epidemiological monitoring, and policy and regulation. The abstract underscored the importance of balancing screen time with physical activity and cultivating a culture of health and wellness in the e-sports community amid technological advancements and evolving trends.
简要概述突出了电子竞技和游戏不断发展的领域,强调了竞技游戏的兴起、其对健康和福祉的影响,以及调整公共战略以适应数字领域的必要性。它探讨了电子竞技的发展、与延长屏幕时间有关的问题以及促进游戏玩家体育锻炼的价值。摘要强调了电子竞技的动向和预测,如持续扩张、主流接受度、项目多样化、移动游戏的突出地位、专业化程度的提高、新兴技术的整合以及地区性传播。此外,摘要还探讨了如何使公共卫生举措适应数字空间,如数字健康促进、在线心理帮助、数字扫盲和健康教育、流行病学监测以及政策和监管。摘要强调了在技术进步和不断发展的趋势下,平衡屏幕时间与体育锻炼的重要性,以及在电子竞技界培养健康文化的重要性。
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引用次数: 0
EXTRAGENITAL LICHEN SCLEROSUS ET ATROPHICUS : A CASE REPORT 眶外硬化萎缩性苔癣:病例报告
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18355
M. Elomari Alaoui, A. Fliti, Ismail Boujida, Mariame Meziane, K. Znati, L. Benzekri, Nadia Ismaili, K. Senouci
Lichen sclerosus et atrophicus (LSA) most commonly presents as atrophic plaques in the genital region but rarely can occur in extra-genital locations (1), reportedly present in 6% to 20% of patients. Its a pathology that can be underdiagnosed and under-treated. The diagnosis should be confirmed with a skin biopsy, and early, thorough treatment should be initiated.(2)We report a case of lichen sclerosus et atrophicus in a woman with purely cutaneous involvement.
萎缩性硬皮病(LSA)最常见的症状是生殖器部位出现萎缩性斑块,但也极少发生在生殖器以外的部位(1),据报道有 6% 至 20% 的患者会出现这种症状。这种病可能诊断不足、治疗不足。我们报告了一例单纯皮肤受累的女性萎缩性硬化苔癣患者。
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引用次数: 0
UNVEILING THE SPECIALISED REALM OF FORENSIC NURSING IN INDIA 揭示印度法医护理的专业领域
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18269
Ankita Sharma, Pushpa a
This review article delves into the multifaceted field of forensic nursing, scope of the forensic nursing, examining the pivotal role these professionals play at the intersection of healthcare and the legal system. Through an in-depth analysis of key literature, we explore the scope of forensic nursing, eligibility criteria, diverse responsibilities of forensic nurses, their impact on patient care, evidence collection, challenges, opportunities for forensic nurses and their crucial role in the judicial process in Indian context.
这篇综述文章深入探讨了法医护理的多层面领域、法医护理的范围,研究了这些专业人员在医疗保健和法律系统的交叉点上发挥的关键作用。通过对重要文献的深入分析,我们探讨了法医护理的范围、资格标准、法医护士的不同职责、对患者护理的影响、证据收集、法医护士面临的挑战和机遇以及他们在印度司法程序中的关键作用。
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引用次数: 0
A COMPREHENSIVE REVIEW OF LITERATURE ON PRAMEHA 关于普米哈的文献综述
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18353
Sumol Anand Pawar, Neha Rathod
This abstract examines the literature on Prameha, a word that encompasses several metabolic problems, in order to provide light on Ayurvedas unique insights regarding pancreas health. The review delves into historical Ayurvedic literature, examining their viewpoints on preserving pancreatic health and averting issues associated with Prameha. The abstract attempts to offer light on holistic approaches to pancreas health within the Ayurvedic framework by fusing ancient wisdom with new scientific findings. A fuller comprehension of Ayurvedas contributions to contemporary viewpoints on metabolic health comes from this investigation, with possible implications for integrative healthcare practices and preventive measures.
本摘要研究了有关 "Prameha "的文献,"Prameha "一词包含多种新陈代谢问题,旨在阐明阿育吠陀在胰腺健康方面的独特见解。摘要深入探讨了阿育吠陀的历史文献,研究了他们关于保护胰腺健康和避免与 Prameha 相关问题的观点。摘要试图通过将古代智慧与新的科学发现相结合,在阿育吠陀框架内提供有关胰腺健康的整体方法。通过这项调查,可以更全面地了解阿育吠陀对当代代谢健康观点的贡献,并对综合保健实践和预防措施产生可能的影响。
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引用次数: 0
VARICELLA-ZOSTER VIRUS INFECTION IN A PATIENT 12 DAYS POST RITUXIMAB: UNUSUAL CO-PRESENTATION OF SHINGLES AND CHICKENPOX 一名利妥昔单抗注射后 12 天的患者水痘-带状疱疹病毒感染:不寻常的带状疱疹和水痘并发症
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18356
Amani Fliti, Meryem Elomari Alaoui, Mariame Meziane, Nadia Ismaili, Laila Benzekri, K. Senouci
Rituximab, an anti CD20 monoclonal antibody, is used in the management of lymphoproliferative and autoimmune conditions such as pemphigus. As an immunosuppressor, it exposes patients to an increased risk of infection. Two cases of varicella-zoster virus infection post Rituximab were been reported in literature. The coexistence of chickenpox (primary infection) and shingles (reactivation of latent infection) in the same patient has never been reported in the literature, especially after rituximab treatment. Herein we present the first case of association of these 2 manifestations in a patient 12 days after rituximab therapy for pemphigus.
利妥昔单抗是一种抗 CD20 单克隆抗体,用于治疗淋巴增生性疾病和自身免疫性疾病,如丘疹性荨麻疹。作为一种免疫抑制剂,它增加了患者的感染风险。文献报道了两例利妥昔单抗后水痘-带状疱疹病毒感染的病例。文献中从未报道过同一患者同时出现水痘(原发感染)和带状疱疹(潜伏感染再活化)的情况,尤其是在利妥昔单抗治疗后。在此,我们介绍了首例在利妥昔单抗治疗丘疹性荨麻疹 12 天后同时出现这两种表现的患者。
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引用次数: 0
ASSESSING COMMUNICATIVE COMPETENCE AMONG SCHOOL TEACHERS: A CRITICAL ANALYSIS 评估学校教师的交际能力:批判性分析
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18326
Samadhan S. Mane
Effective communication is paramount in the field of education, particularly among school teachers who serve as conduits of knowledge and facilitators of learning. This research article examines the communicative competence of school teachers, exploring its multifaceted dimensions and implications for pedagogical practice. Drawing upon theoretical frameworks and empirical evidence, this study investigates the components of communicative competence, its role in classroom interactions, and the factors influencing its development and enhancement. Additionally, it offers insights into the assessment methods and strategies for fostering communicative competence among school teachers.
在教育领域,有效的沟通至关重要,尤其是作为知识传播者和学习促进者的学校教师。本研究文章探讨了学校教师的沟通能力,探索了其多方面的内涵及其对教学实践的影响。本研究借鉴理论框架和经验证据,探讨了交际能力的组成部分、其在课堂互动中的作用以及影响其发展和提高的因素。此外,本研究还对培养学校教师交际能力的评估方法和策略提出了见解。
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引用次数: 0
EFFECTS OF STEM LEARNING ON CRITICAL AND CREATIVE THINKING SKILLS: A META-ANALYSIS 干中学对批判性和创造性思维能力的影响:荟萃分析
Pub Date : 2024-02-29 DOI: 10.21474/ijar01/18273
Asrizal, Febrian Virijai, Annisa N., Usmeldi
The twenty-first century is marked by increasingly sophisticated advances in science and technology. Critical thinking and creative thinking skills are skills needed in this century. In addition, STEM is also needed to practice these 21st-century skills. However, the reality in the field found that students critical thinking and creative thinking skills are still low. The next fact is that there is still little application of STEM-integrated learning. The solution to overcome these problems is STEM-integrated learning to improve students critical and creative thinking skills. The purpose of this study was to describe the effect size of students critical and creative thinking skills on STEM-integrated learning. The research method used is a meta-analysis. The data collected were 20 national and international articles related to the effect of STEM learning on students critical and creative thinking skills. The strong or weak influence of STEM learning on critical and creative thinking skills is determined by the size of the effect. The results of the meta-analysis showed that the level of education, learning models, and learning materials showed that the influence of STEM learning on students critical and creative thinking skills was in the high category. This research provides an opportunity for future research to develop STEM-integrated learning to improve other twenty-first-century skills at every level of education, relate them to learning models, and apply them to every learning material.
二十一世纪的特点是科学技术日益进步。批判性思维和创造性思维能力是本世纪所需要的技能。此外,STEM 也是实践这些 21 世纪技能的需要。然而,现实情况表明,学生的批判性思维和创造性思维能力仍然很低。其次,STEM 整合学习的应用仍然很少。解决这些问题的办法就是通过 STEM 整合学习来提高学生的批判性思维和创造性思维能力。本研究旨在描述学生批判性和创造性思维能力对 STEM 整合学习的影响大小。采用的研究方法是荟萃分析法。收集的数据是 20 篇与 STEM 学习对学生批判性和创造性思维能力的影响相关的国内外文章。STEM学习对批判性和创造性思维能力影响的强弱取决于影响的大小。荟萃分析结果表明,从教育水平、学习模式和学习材料来看,STEM 学习对学生批判性和创造性思维能力的影响属于高影响范畴。这项研究为今后的研究提供了一个契机,即在各个教育阶段开展 STEM 整合学习以提高其他 21 世纪技能,并将其与学习模式联系起来,应用到每一种学习材料中。
{"title":"EFFECTS OF STEM LEARNING ON CRITICAL AND CREATIVE THINKING SKILLS: A META-ANALYSIS","authors":"Asrizal, Febrian Virijai, Annisa N., Usmeldi","doi":"10.21474/ijar01/18273","DOIUrl":"https://doi.org/10.21474/ijar01/18273","url":null,"abstract":"The twenty-first century is marked by increasingly sophisticated advances in science and technology. Critical thinking and creative thinking skills are skills needed in this century. In addition, STEM is also needed to practice these 21st-century skills. However, the reality in the field found that students critical thinking and creative thinking skills are still low. The next fact is that there is still little application of STEM-integrated learning. The solution to overcome these problems is STEM-integrated learning to improve students critical and creative thinking skills. The purpose of this study was to describe the effect size of students critical and creative thinking skills on STEM-integrated learning. The research method used is a meta-analysis. The data collected were 20 national and international articles related to the effect of STEM learning on students critical and creative thinking skills. The strong or weak influence of STEM learning on critical and creative thinking skills is determined by the size of the effect. The results of the meta-analysis showed that the level of education, learning models, and learning materials showed that the influence of STEM learning on students critical and creative thinking skills was in the high category. This research provides an opportunity for future research to develop STEM-integrated learning to improve other twenty-first-century skills at every level of education, relate them to learning models, and apply them to every learning material.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":"31 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140408725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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International Journal of Advanced Research
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