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Dust-phase phthalates in university dormitories in Beijing, China: pollution characteristics, potential sources, and non-dietary oral exposure. 中国北京大学宿舍的尘相邻苯二甲酸盐:污染特征、潜在来源和非膳食口服暴露。
IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-02-09 DOI: 10.1080/09603123.2024.2313184
Ruixin Zhang, Fang Liu, Lixin Wang, Zaixing Wu, Liujia Fan, Bing Liu, Hong Shang

This study aimed to determine dust-phase phthalate levels in 112 dormitories of 14 universities during autumn and winter, investigate their potential sources, and estimate phthalate exposure via dust ingestion. Twelve phthalates were detected, among which di-(2-ethylhexyl) phthalate (DEHP) and dicyclohexyl phthalate (DCHP) were the most abundant, followed by di-isobutyl phthalate (DiBP) and di-n-butyl phthalate (DnBP). The median concentrations and contributions of DCHP and DEHP were the highest. The contributions of di-n-octyl phthalate and di-nonyl phthalate were higher in winter than in autumn. Potential sources included iron furniture, chemical fiber textiles, clothes, and personal care products. Medium-density fiberboard furniture is a potential sink for phthalates. In two seasons, DEHP, DCHP, DiBP, and DnBP were the main phthalates ingested by college students . The median oral exposure of ten phthalates was higher in females than in males. College students have a high risk of exposure to DEHP in dormitories.

这项研究旨在测定14所大学112间宿舍在秋冬季的尘埃相邻苯二甲酸盐含量,调查其潜在来源,并估算通过摄入尘埃接触邻苯二甲酸盐的情况。研究共检测到 12 种邻苯二甲酸酯,其中含量最高的是邻苯二甲酸二(2-乙基己基)酯(DEHP)和邻苯二甲酸二环己基酯(DCHP),其次是邻苯二甲酸二异丁酯(DiBP)和邻苯二甲酸二正丁酯(DnBP)。邻苯二甲酸二异丁酯(DiBP)和邻苯二甲酸二正丁酯(DnBP)的浓度中值和贡献率最高。邻苯二甲酸二正辛酯和邻苯二甲酸二壬酯的含量在冬季高于秋季。潜在来源包括铁制家具、化纤纺织品、衣物和个人护理产品。中密度纤维板家具是邻苯二甲酸盐的潜在来源。在两个季节中,DEHP、DCHP、DiBP 和 DnBP 是大学生摄入的主要邻苯二甲酸盐。女性口腔接触 10 种邻苯二甲酸盐的中位数高于男性。大学生在宿舍中接触 DEHP 的风险很高。
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引用次数: 0
Planetary health education in the United States: four curricular models, one goal. 美国的行星健康教育:四种课程模式,一个目标。
IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-02-13 DOI: 10.1080/09603123.2024.2316185
Kathryn H Jacobsen, Katelyn A Marchione, Carlos A Faerron Guzmán, A Alonso Aguirre, Caryl E Waggett

Global environmental crises demand scaled-up investment in education about planetary health. We identified college and university programs in the United States that focus on the human-animal-ecosystem nexus by systematically searching the 2023-2024 catalogs of more than 1000 schools. We identified four frequently-used curricular models: (1) One Health programs offered by universities with veterinary and agriculture schools that emphasize zoonotic diseases, antimicrobial resistance, food safety, and wildlife conservation; (2) climate change and health (climate medicine) programs for graduate and professional students at large universities with medical and public health schools; (3) global environmental public health programs focused on pollution and other exposures; and (4) sustainability and health programs emphasizing food security, environmental justice, and other health issues that can be improved with ethical design and engineering. Highlighting the shared goals of these distinct academic models may help make planetary health a more visible area of teaching, research, and practice.

全球环境危机要求加大对地球健康教育的投资。我们通过系统地搜索了美国 1000 多所学校的 2023-2024 年目录,确定了重点关注人类-动物-生态系统关系的大专院校课程。我们发现了四种常用的课程模式:(1) 设有兽医和农业学院的大学开设的 "一体健康 "课程,强调人畜共患病、抗菌药耐药性、食品安全和野生动物保护;(2) 设有医学和公共卫生学院的大型大学为研究生和专业学生开设的气候变化与健康(气候医学)课程;(3) 全球环境公共健康课程,侧重于污染和其他暴露问题;(4) 可持续发展与健康课程,强调食品安全、环境正义和其他可通过道德设计和工程改善的健康问题。强调这些不同学术模式的共同目标可能有助于使行星健康成为教学、研究和实践的一个更引人注目的领域。
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引用次数: 0
Adherence to the Mediterranean diet is associated with sustainable nutrition and environmental footprints on higher educated individuals. 坚持地中海饮食与受过高等教育的人的可持续营养和环境足迹有关。
IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-01-22 DOI: 10.1080/09603123.2024.2308732
Nilgün Seremet Kürklü, Merve Şeyda Karaçİl Ermumcu, Gülen Suna, Caner Özyıldırım, Kübra Tel Adigüzel, Melis Aydın, Aleyna Kavalcı, Fatmanur Bozdağ, Nur Turgut

Introduction: This study aimed to investigate the relationship between Med-Diet adherence with sustainable nutrition and environmental footprints in academicians. Methods: The study involved 153 academicians aged 23-64 working in a university in Turkey. Data were collected through a questionnaire including socio-demographic characteristics, anthropometric measurements, Mediterranean Diet Adherence Scale (MEDAS) and Sustainable and Healthy Eating Behaviours Scale (SHEBS). Carbon and water footprints were calculated. Results: All sub-scales of SHEBS were higher in individuals who adhered to Med-Diet than those who did not (p<0.05). The carbon and water footprints of individuals with high adherence to the Med-Diet were lower than those of no adherence (p<0.05). Each 1-point increase in MEDAS score was associated with a 1-point increase in SHEBS score, a 0.15 CO2 eq/kg and a 0.001 m3/year decrease in the amount of carbon and water footprint of food. Conclusion: Higher adherence to the Med-Diet was associated with higher sustainable nutrition behaviours, and lower environmental footprints.

引言本研究旨在探讨坚持地中海饮食与院士的可持续营养和环境足迹之间的关系:这项研究涉及在土耳其一所大学工作的 153 名 23-64 岁的院士。通过问卷收集数据,包括社会人口特征、人体测量、地中海饮食坚持量表(MEDAS)和可持续健康饮食行为量表(SHEBS)。计算了碳足迹和水足迹:结果:坚持 "健康饮食 "者的可持续和健康饮食行为量表的所有分量表均高于未坚持者(p 结论:坚持 "健康饮食 "者的可持续和健康饮食行为量表的分量表均高于未坚持者:较高的 "健康饮食 "坚持率与较高的可持续营养行为和较低的环境足迹有关。
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引用次数: 0
Exposure to mixtures of PM2.5 components and term premature rupture of membranes: a case-crossover study in Shijiazhuang, China. 接触 PM2.5 混合物与胎膜早破:中国石家庄的病例交叉研究。
IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-01-25 DOI: 10.1080/09603123.2024.2308017
Weiyan Ren, Huangmin Yang, Wencong Liu, Shaochong Zhang, Yanjing Yang, Lei Yang, Wenxuan Liu, Haijuan Zhang, Ke He, Xia Li, Jun Ge

This study aims to explore the acute effects of short-term exposure to PM2.5 components and their mixture on PROM. Counts of hospital admissions due to PROM were collected at the Fourth Hospital of Shijiazhuang. The associations between the PROM and PM2.5 components was examined using a time-stratified case-crossover approach. The overall effects of components on TPROM were examined using the BKMR. During the study period 30,709 cases of PROMwere identified. The relative risks and the 95% CI of TPROM were 1.013 (1.002, 1.028) and 1.015 (1.003, 1.028) associated with per interquartile range increase in nitrate and ammonium ion on the current day and they were 1.007 (1.001, 1.013) and 1.003 (1.000, 1.005) on the previous day. The results from the BKMR models showed a higher risk of TPROM was associated with exposure to mixtures, in which, nitrate and organic matter were the main contributors to the overall effect.

本研究旨在探讨短期暴露于PM2.5成分及其混合物对PROM的急性影响。在石家庄市第四医院收集了因PROM而入院的人数。采用时间分层病例交叉法研究了PROM与PM2.5成分之间的关系。使用BKMR检验了各组分对TPROM的总体影响。在研究期间,共发现了 30 709 例 PROM。当日硝酸盐和铵离子的相对风险和 95% CI 分别为 1.013 (1.002, 1.028) 和 1.015 (1.003, 1.028),而前一天硝酸盐和铵离子的相对风险和 95% CI 分别为 1.007 (1.001, 1.013) 和 1.003 (1.000, 1.005)。BKMR 模型的结果显示,较高的 TPROM 风险与接触混合物有关,其中硝酸盐和有机物是造成总体影响的主要因素。
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引用次数: 0
Acceptability and tolerability of alcohol-based hand rubs among health workers and concessionaires in Malaysia during the COVID pandemic: a hospital-wide cross-sectional study using a modified WHO protocol. 在 COVID 大流行期间,马来西亚卫生工作者和特许经营者对酒精擦手液的接受度和耐受性:一项采用世卫组织修订方案进行的全医院横断面研究。
IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-01-29 DOI: 10.1080/09603123.2024.2309324
Yew Fong Lee, Wei Hong Lai, Peh Yee Lee, Samual Chuo Yew Ting, Irena Albert Nuja, Hie Ung Ngian, Jiancong Wang

This study evaluated the acceptability and tolerability of three alcohol-based hand rubs (ABHRs) at Sarawak General Hospital, Malaysia. Conducted from 12-26 November 2021 using a modified WHO Protocol, it involved a survey among health workers and concessionaires, with a 35% response rate (1,598 of 4,628 participants). The majority were nurses (60.8%), with the medical division most represented (28.4%). Most respondents (93.2%) used ABHRs at least five days a week and found them easily accessible (72.3%). Product B was the preferred ABHR (65%), primarily for its color and fragrance, surpassing WHO's 50% approval rate in these aspects. However, no other product features met WHO criteria. There were no significant differences in self-reported skin tolerability across the products, and none achieved overall WHO approval. These results offer important insights for ABHR selection in developing countries and highlight the value of the WHO Protocol in assessing product acceptability and tolerability.

本研究评估了马来西亚沙捞越总医院对三种酒精擦手液(ABHR)的接受度和耐受性。研究于 2021 年 11 月 12 日至 26 日进行,采用了经修订的世界卫生组织协议,对卫生工作者和特许经营者进行了调查,回复率为 35%(4628 名参与者中有 1598 名)。大多数受访者是护士(60.8%),医务人员占大多数(28.4%)。大多数受访者(93.2%)每周至少有五天使用 ABHR,并认为 ABHR 方便使用(72.3%)。产品 B 是首选的 ABHR(65%),主要是因为其颜色和香味,在这些方面超过了世卫组织 50%的认可率。然而,没有其他产品特征符合世卫组织的标准。各种产品在自我报告的皮肤耐受性方面没有明显差异,也没有一种产品获得世卫组织的全面认可。这些结果为发展中国家选择 ABHR 提供了重要启示,并强调了世卫组织议定书在评估产品可接受性和耐受性方面的价值。
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引用次数: 0
Enhancing antioxidant yield from carob (Ceratonia siliqua L.): evaluating the efficacy of maceration and ultrasound-assisted methods. 提高角豆树(Ceratonia siliqua L.)的抗氧化剂产量:评估浸渍法和超声波辅助法的功效。
IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-27 DOI: 10.1080/09603123.2024.2407456
Ghofrane Ben Hamouda, Iness Bettaieb Rebey, Feten Zar Kalai, Majdi Hammami, Riadh Ksouri

  Our study aimed to optimize carob antioxidant extraction for use in the food, cosmetic, and pharmaceutical industries. Maceration investigated ethanol concentration, extraction temperature, and time, while ultrasound-assisted extraction examined ethanol concentration, ultrasound power, and time. A central composite design with 19 experimental points assessed the influence of variables on total yield, total phenolic content, and antioxidant activity. The results were analyzed to optimize the extraction parameters and enhance the antioxidant extraction from carob. The results of the study show that the best maceration condition for extracting antioxidants from the plant material was found to have a time of 24.38 minutes, an ethanol content of 59.02%, and a temperature of 54.52°C. Similarly, the optimal conditions for ultrasound-assisted extraction were found to be 51.49 minutes, 79.78% sonication power, and 76.12% alcohol. The optimal conditions identified can be used as a starting point for further optimization and scaling up of the extraction process.

我们的研究旨在优化角豆树抗氧化剂的提取,以用于食品、化妆品和制药行业。浸渍法研究了乙醇浓度、萃取温度和时间,而超声辅助萃取法研究了乙醇浓度、超声功率和时间。19个实验点的中心复合设计评估了变量对总产量、总酚含量和抗氧化活性的影响。分析结果旨在优化萃取参数,提高角豆树的抗氧化萃取效果。研究结果表明,从植物材料中提取抗氧化剂的最佳浸渍条件是浸渍时间为 24.38 分钟,乙醇含量为 59.02%,温度为 54.52°C。同样,超声辅助萃取的最佳条件为 51.49 分钟、超声功率 79.78%、酒精含量 76.12%。确定的最佳条件可作为进一步优化和扩大萃取过程的起点。
{"title":"Enhancing antioxidant yield from carob (<i>Ceratonia siliqua</i> L.): evaluating the efficacy of maceration and ultrasound-assisted methods.","authors":"Ghofrane Ben Hamouda, Iness Bettaieb Rebey, Feten Zar Kalai, Majdi Hammami, Riadh Ksouri","doi":"10.1080/09603123.2024.2407456","DOIUrl":"https://doi.org/10.1080/09603123.2024.2407456","url":null,"abstract":"<p><p>  Our study aimed to optimize carob antioxidant extraction for use in the food, cosmetic, and pharmaceutical industries. Maceration investigated ethanol concentration, extraction temperature, and time, while ultrasound-assisted extraction examined ethanol concentration, ultrasound power, and time. A central composite design with 19 experimental points assessed the influence of variables on total yield, total phenolic content, and antioxidant activity. The results were analyzed to optimize the extraction parameters and enhance the antioxidant extraction from carob. The results of the study show that the best maceration condition for extracting antioxidants from the plant material was found to have a time of 24.38 minutes, an ethanol content of 59.02%, and a temperature of 54.52°C. Similarly, the optimal conditions for ultrasound-assisted extraction were found to be 51.49 minutes, 79.78% sonication power, and 76.12% alcohol. The optimal conditions identified can be used as a starting point for further optimization and scaling up of the extraction process.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of dermal exposure to phthalates and parabens resulting from the use of hair relaxers. 评估因使用松发剂而导致皮肤接触邻苯二甲酸盐和对羟基苯甲酸酯的情况。
IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-20 DOI: 10.1080/09603123.2024.2402836
Jennifer S Pierce, Drew Cheatham, Devan A Campbell, Raúl F Lazcano, Courtney E Busch, Eric W Miller, Evan M Beckett

Hair relaxers have been suggested as a source of exposure to parabens and phthalates. However, dermally absorbed doses of these chemicals resulting from consumer use of hair relaxers have yet to be quantified, and results from epidemiological studies have consistently demonstrated that there is no increased risk for hormone-sensitive, reproductive cancers associated with use of hair relaxers among Black women. Therefore, dermal absorption of parabens and phthalates associated with hair relaxer use for several commercially available hair relaxer kits was modeled using IH SkinPerm™. The chemicals detected in the hair relaxer kits included methylparaben (MP), ethylparaben (EP), butylparaben (BP), diethyl phthalate (DEP), bis(2-ethylhexyl) phthalate (DEHP), and the phthalate substitute bis(2-ethylhexyl) adipate (DEHA). The daily absorbed dose ranges (mg/kg/day), standardized over a year of product use, were as follows: 8.64 × 10-5-0.00116 MP, 2.30 × 10-8-3.07 × 10-6 EP, 3.24 × 10-8-4.33 × 10-6 BP, 8.65 × 10-9-1.15 × 10-6 DEP, and 8.94 × 10-7-0.000119 DEHP for Kit #1; 8.44 × 10-5-0.00113 MP and 7.91 × 10-5-0.00106 DEP for Kit #2; and 2.49 × 10-6-3.33 × 10-5 MP, 1.52 × 10-8-2.03 × 10-6 EP, 3.29 × 10-9-4.39 × 10-7 DEP, and 3.11 × 10-6-4.14 × 10-5 DEHA for Kit #3. These absorbed doses were well below applicable health-based guidance values, indicating consumer exposure from product use is not expected to pose a health risk. These results provide valuable information for health risk evaluations for hair relaxer use.

有人认为,松发剂是接触对羟基苯甲酸酯和邻苯二甲酸酯的一个来源。然而,消费者使用松发剂导致皮肤吸收这些化学物质的剂量尚未得到量化,而且流行病学研究结果一致表明,黑人妇女使用松发剂不会增加罹患对激素敏感的生殖系统癌症的风险。因此,我们使用 IH SkinPerm™ 对几种市售松发剂套件中与使用松发剂有关的对羟基苯甲酸酯和邻苯二甲酸酯的皮肤吸收进行了模拟。在松发剂套装中检测到的化学物质包括对羟基苯甲酸甲酯 (MP)、对羟基苯甲酸乙酯 (EP)、对羟基苯甲酸丁酯 (BP)、邻苯二甲酸二乙酯 (DEP)、邻苯二甲酸二(2-乙基己基)酯 (DEHP) 和邻苯二甲酸酯替代物己二酸二(2-乙基己基)酯 (DEHA)。产品使用一年后的标准日吸收剂量范围(毫克/千克/天)如下:试剂盒 #1 的日吸收剂量范围(毫克/千克/天)如下:8.64 × 10-5-0.00116 MP、2.30 × 10-8-3.07 × 10-6 EP、3.24 × 10-8-4.33 × 10-6 BP、8.65 × 10-9-1.15 × 10-6 DEP 和 8.94 × 10-7-0.000119 DEHP;试剂盒 #2 的日吸收剂量范围(毫克/千克/天)如下:8.44 × 10-5-0.00113 MP 和 7.试剂盒#2:8.44 × 10-5-0.00113 MP 和 7.91 × 10-5-0.00106 DEP;试剂盒#3:2.49 × 10-6-3.33 × 10-5 MP、1.52 × 10-8-2.03 × 10-6 EP、3.29 × 10-9-4.39 × 10-7 DEP 和 3.11 × 10-6-4.14 × 10-5 DEHA。这些吸收剂量远低于适用的基于健康的指导值,表明消费者因使用产品而接触这些物质预计不会造成健康风险。这些结果为松发剂使用的健康风险评估提供了有价值的信息。
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引用次数: 0
The influence of specific weather types on stroke occurrence: an analysis of 23,000 patients from Augsburg, Germany. 特定天气类型对中风发生率的影响:对德国奥格斯堡 23,000 名患者的分析。
IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-20 DOI: 10.1080/09603123.2024.2404474
Jonathan Simon, Michael Ertl, Markus Naumann, Lino Braadt, Gertrud Hammel, Andreas Philipp, Jucundus Jacobeit, Christoph Beck

For the first time, the relationships between large-scale weather types and local stroke events in the urban area of Augsburg, Germany are analyzed. Over 23,000 stroke cases (2006 - 2020) were standardized to account for long-term trends and seasonality. Using ERA5 reanalysis data, a composite analysis identified stroke-related atmospheric variables, while seasonal weather types were classified via the neural network algorithm of self-organizing maps. Cyclonic westerlies during the cold season, which transport warm air masses from the Atlantic Ocean to Germany, were a major risk factor for ischemic stroke, while colder easterly conditions reduced stroke incidence. In the warm season, both anticyclonic conditions and westerly/northerly air advection, leading to slightly warmer or distinctly colder temperatures, were linked to increased ischemic stroke risk. Additionally, hemorrhagic strokes in the cold season were triggered by weather conditions contrary to those associated with ischemic strokes and transitory ischemic attacks.

该研究首次分析了德国奥格斯堡城区大尺度天气类型与当地中风事件之间的关系。对 23,000 多例中风病例(2006 - 2020 年)进行了标准化处理,以考虑长期趋势和季节性。利用ERA5再分析数据,通过综合分析确定了与中风相关的大气变量,并通过自组织地图的神经网络算法对季节性天气类型进行了分类。寒冷季节的旋风西风将暖气团从大西洋输送到德国,是缺血性中风的主要风险因素,而寒冷的东风则降低了中风的发病率。在暖季,反气旋条件和西风/北风空气平流导致气温略高或明显偏低,都与缺血性中风风险增加有关。此外,寒冷季节引发出血性中风的天气条件与缺血性中风和短暂性缺血性发作的天气条件相反。
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引用次数: 0
Antioxidants from Rubus idaeus leaves: LC-MS/MS chemical profiling, in vitro antiglycation, α-glucosidase and α-amylase inhibitory activities. 茜草叶中的抗氧化剂:LC-MS/MS 化学分析、体外抗糖化、α-葡萄糖苷酶和α-淀粉酶抑制活性。
IF 3.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-18 DOI: 10.1080/09603123.2024.2404248
El Asri Sara,Ben Mrid Reda,Zouaoui Zakia,Chibuye Bitwell,Ennoury Abdelhamid,Kabach Imad,Nhiri Mohamed,Chibi Fatiha
The present study evaluated a range of biological activities of Rubus idaeus leaves, often considered as by-products, in relation to hyperglycemia. The antiglycation potential of this plant has not been previously reported. In this research, the methanolic leaf extract of R. idaeus was assessed for its antioxidant, enzyme inhibitory and antiglycation activities. The bioactive compounds present in the extract were screened using LC-MS/MS. Enzyme inhibitory activities were tested on α-glucosidase and α-amylase, and the antiglycation effect was investigated using BSA-fructose model. The methanolic extract showed a high polyphenolic contents (176.26 ± 2.26 mg GAE/g) and important IC50 values for DPPH (34.79 ± 2.40 µg/mL) and ABTS radical scavenging activities (49.75 ± 2.47 µg/mL). In addition, the plant leaf extract significantly inhibited hyperglycemia-related enzymes in a dose-dependent manner and demonstrated a reduction in fluorescent AGEs, fructosamine, and dicarbonyl compounds. Therefore, R. idaeus cv Maravilla could be an effective source of therapeutics for improving the healthcare outcomes of diabetic patients.
本研究评估了通常被视为副产品的茜草叶与高血糖有关的一系列生物活性。这种植物的抗糖化潜力以前还没有报道过。在这项研究中,我们评估了茜草叶甲醇提取物的抗氧化、酶抑制和抗糖化活性。使用 LC-MS/MS 对提取物中的生物活性化合物进行了筛选。测试了对α-葡萄糖苷酶和α-淀粉酶的酶抑制活性,并使用 BSA-果糖模型研究了抗糖化作用。甲醇提取物显示出较高的多酚含量(176.26 ± 2.26 mg GAE/g),DPPH(34.79 ± 2.40 µg/mL)和 ABTS 自由基清除活性的 IC50 值(49.75 ± 2.47 µg/mL)也很高。此外,该植物叶提取物以剂量依赖的方式明显抑制了与高血糖相关的酶,并减少了荧光 AGEs、果糖胺和二羰基化合物。因此,R. idaeus cv Maravilla 可以作为一种有效的治疗药物来源,改善糖尿病患者的治疗效果。
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引用次数: 0
Effect and interaction of PINK1 genetic polymorphisms and environmental factors on blood pressure in COEs-exposed workers. PINK1 基因多态性和环境因素对接触 COE 的工人血压的影响和相互作用。
IF 3.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-18 DOI: 10.1080/09603123.2024.2403685
Jing Sun,Yang Chen,Xiangkai Zhao,Zeming Niu,Zhiguang Gu,Zhaofan Yan,Wei Wang
Coke oven emissions (COEs) contain a variety of polycyclic aromatic hydrocarbons (PAHs), which can cause damage to the human cardiovascular system. In addition, myocardial mitochondria are susceptible to damage in hypertensive patients. However, it is not clear whether genetic variation, in single nucleotide polymorphisms (SNPs) in PINK1 affects COEs exposure-induced abnormal blood pressure. We surveyed and tested 518 workers exposed to COEs and statistically analyzed them with SPSS 21.0 software. SBP was greater in the high-exposure group than in the low-exposure group. Generalized linear model analysis showed that the interaction of PINK1 rs3738136 (GA+AA) and COEs had an effect on SBP [β(95%CI) = -6.537(-12.072, -1.002), p = 0.021] and DBP [β(95%CI) = -4.811(-8.567, -1.056), p = 0.012]. This study is the first to identify the role of PINK1 rs3738136 in COE- induced abnormal blood pressure, and to prove that the abnormal blood pressure of workers is the result of environmental and genetic factors.
焦炉排放物(COEs)含有多种多环芳烃(PAHs),可对人体心血管系统造成损害。此外,高血压患者的心肌线粒体也容易受损。然而,PINK1 的单核苷酸多态性(SNPs)遗传变异是否会影响 COEs 暴露引起的血压异常,目前尚不清楚。我们对 518 名接触 COEs 的工人进行了调查和测试,并使用 SPSS 21.0 软件进行了统计分析。高接触组的 SBP 高于低接触组。广义线性模型分析表明,PINK1 rs3738136 (GA+AA) 与 COEs 的交互作用对 SBP [β(95%CI) = -6.537(-12.072, -1.002), p = 0.021] 和 DBP [β(95%CI) = -4.811(-8.567, -1.056), p = 0.012]有影响。本研究首次确定了 PINK1 rs3738136 在 COE 诱导的血压异常中的作用,并证明工人的血压异常是环境和遗传因素共同作用的结果。
{"title":"Effect and interaction of PINK1 genetic polymorphisms and environmental factors on blood pressure in COEs-exposed workers.","authors":"Jing Sun,Yang Chen,Xiangkai Zhao,Zeming Niu,Zhiguang Gu,Zhaofan Yan,Wei Wang","doi":"10.1080/09603123.2024.2403685","DOIUrl":"https://doi.org/10.1080/09603123.2024.2403685","url":null,"abstract":"Coke oven emissions (COEs) contain a variety of polycyclic aromatic hydrocarbons (PAHs), which can cause damage to the human cardiovascular system. In addition, myocardial mitochondria are susceptible to damage in hypertensive patients. However, it is not clear whether genetic variation, in single nucleotide polymorphisms (SNPs) in PINK1 affects COEs exposure-induced abnormal blood pressure. We surveyed and tested 518 workers exposed to COEs and statistically analyzed them with SPSS 21.0 software. SBP was greater in the high-exposure group than in the low-exposure group. Generalized linear model analysis showed that the interaction of PINK1 rs3738136 (GA+AA) and COEs had an effect on SBP [β(95%CI) = -6.537(-12.072, -1.002), p = 0.021] and DBP [β(95%CI) = -4.811(-8.567, -1.056), p = 0.012]. This study is the first to identify the role of PINK1 rs3738136 in COE- induced abnormal blood pressure, and to prove that the abnormal blood pressure of workers is the result of environmental and genetic factors.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":"2 1","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Environmental Health Research
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