Pub Date : 2011-12-21DOI: 10.1504/IJLR.2011.044196
Rohit Mehra, P. Bala, K. Badhan, R. Sonkawade
Samples of Ordinary Portland Cement (OPC) and Portland Pozzolana Cement (PPC) from five companies were analysed for the measurement of 226 Ra, 232 Th and 40 K using a HPGe detector based on high-resolution gamma spectrometry system. The measured activity in the selected OPC cement samples varies from 19.24 Bq kg −1 (JK Laxmi) to 40.73 Bq kg −1 (JayPee), 29.49 Bq kg −1 (JK Laxmi) to 42.17 Bq kg −1 (JayPee) and 228.25 Bq kg −1 (JK Cement) to 304.98 Bq kg −1 (Binani) for 226 Ra, 232 Th and 40 K, respectively. The concentration of radium, thorium and potassium in the selected PPC cement samples varies from 22.50 Bq kg −1 (JK Laxmi) to 48.83 Bq kg −1 (Binani), 30.74 Bq kg −1 (JK Laxmi) to 70.48 Bq kg −1 (Binani) and 267.94 Bq kg −1 (Binani) to 328.88 Bq kg −1 (JayPee), respectively. Radium equivalent, annual effective dose, absorbed dose and hazard indices were also calculated for the measured samples.
使用基于高分辨率伽马能谱系统的HPGe探测器，分析了五家公司的普通硅酸盐水泥(OPC)和硅酸盐硅酸盐水泥(PPC)样品，测量了226 Ra, 232 Th和40 K。对于226 Ra、232 Th和40 K，所选OPC水泥样品的测量活度分别为19.24 Bq kg - 1 (JK Laxmi)至40.73 Bq kg - 1 (JayPee)、29.49 Bq kg - 1 (JK Laxmi)至42.17 Bq kg - 1 (JayPee)和228.25 Bq kg - 1 (JK cement)至304.98 Bq kg - 1 (Binani)。所选PPC水泥样品中镭、钍和钾的浓度分别为22.50 Bq kg - 1 (JK Laxmi) ~ 48.83 Bq kg - 1 (Binani)、30.74 Bq kg - 1 (JK Laxmi) ~ 70.48 Bq kg - 1 (Binani)和267.94 Bq kg - 1 (Binani) ~ 328.88 Bq kg - 1 (JayPee)。计算了所测样品的镭当量、年有效剂量、吸收剂量和危害指数。
{"title":"Assessment of radiation dose due to natural radionuclides in various cement samples","authors":"Rohit Mehra, P. Bala, K. Badhan, R. Sonkawade","doi":"10.1504/IJLR.2011.044196","DOIUrl":"https://doi.org/10.1504/IJLR.2011.044196","url":null,"abstract":"Samples of Ordinary Portland Cement (OPC) and Portland Pozzolana Cement (PPC) from five companies were analysed for the measurement of 226 Ra, 232 Th and 40 K using a HPGe detector based on high-resolution gamma spectrometry system. The measured activity in the selected OPC cement samples varies from 19.24 Bq kg −1 (JK Laxmi) to 40.73 Bq kg −1 (JayPee), 29.49 Bq kg −1 (JK Laxmi) to 42.17 Bq kg −1 (JayPee) and 228.25 Bq kg −1 (JK Cement) to 304.98 Bq kg −1 (Binani) for 226 Ra, 232 Th and 40 K, respectively. The concentration of radium, thorium and potassium in the selected PPC cement samples varies from 22.50 Bq kg −1 (JK Laxmi) to 48.83 Bq kg −1 (Binani), 30.74 Bq kg −1 (JK Laxmi) to 70.48 Bq kg −1 (Binani) and 267.94 Bq kg −1 (Binani) to 328.88 Bq kg −1 (JayPee), respectively. Radium equivalent, annual effective dose, absorbed dose and hazard indices were also calculated for the measured samples.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"156"},"PeriodicalIF":0.0,"publicationDate":"2011-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.044196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-21DOI: 10.1504/IJLR.2011.044193
S. Kansal, Rohit Mehra, N. P. Singh
Indoor radon studies have been carried out in 100 dwellings of 20 villages in western districts of Haryana, India, using the solid-state nuclear track detector technique. LR-115 Type II films in the bare mode were exposed for 1 year on a quarterly basis to cover all the four seasons for the measurement of indoor radon levels. The annual average indoor radon concentration in the study area varies from 126 to 546 Bq∙m −3 , with an average value of 252 Bq∙m −3 . Seasonal variation of indoor radon shows higher values in winter and lower values in summer. Lifetime fatality risk assessment and annual average dose received by the residents of the study area are also calculated to be within the recommended safe limit of 3–10 mSv per year. Hence, there is no significant threat to the residents due to presence of natural radon in the dwellings.
{"title":"Measurement of indoor radon concentration in the dwellings of Western Haryana, India, for health risk assessment","authors":"S. Kansal, Rohit Mehra, N. P. Singh","doi":"10.1504/IJLR.2011.044193","DOIUrl":"https://doi.org/10.1504/IJLR.2011.044193","url":null,"abstract":"Indoor radon studies have been carried out in 100 dwellings of 20 villages in western districts of Haryana, India, using the solid-state nuclear track detector technique. LR-115 Type II films in the bare mode were exposed for 1 year on a quarterly basis to cover all the four seasons for the measurement of indoor radon levels. The annual average indoor radon concentration in the study area varies from 126 to 546 Bq∙m −3 , with an average value of 252 Bq∙m −3 . Seasonal variation of indoor radon shows higher values in winter and lower values in summer. Lifetime fatality risk assessment and annual average dose received by the residents of the study area are also calculated to be within the recommended safe limit of 3–10 mSv per year. Hence, there is no significant threat to the residents due to presence of natural radon in the dwellings.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"122"},"PeriodicalIF":0.0,"publicationDate":"2011-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.044193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-13DOI: 10.1504/IJLR.2011.044191
C. Colin, A. Granzotto, C. Devic, C. Massart, M. Viau, G. Vogin, M. Maalouf, A. Joubert, N. Foray
Unrepaired and misrepaired DNA Double-Strand Breaks (DSBs) were shown to be the key events of radiation-induced toxicity (radiosensitivity) and genomic instability (cancer proneness), respectively. We have previously shown that immunofluorescence with γ -H2AX and MRE11 biomarkers may account for unrepaired and misrepaired DSBs for doses higher than 1 Gy. Three radiosensitivity groups had been defined (group I: radioresistance; group II: moderate radiosensitivity and cancer proneness; group III: hyper-radiosensitivity). Here, we investigated X-ray doses ranging from 9 mGy to 2 Gy in three cell lines representative of these radiosensitivity groups. We observed a non-linear dose-dependent increase of the severity of DSB, suggesting a correlation with the phenomenon of hyper-radiosensitivity to low dose; a non-linear dose-dependent increase of MRE11 foci, revealing a dose-threshold for the radiation-induced genomic instability. Altogether, these data document the evidence of a threshold in low-dose response and strongly suggest the impact of individual factor.
{"title":"MRE11 and H2AX biomarkers in the response to low-dose exposure: balance between individual susceptibility to radiosensitivity and to genomic instability","authors":"C. Colin, A. Granzotto, C. Devic, C. Massart, M. Viau, G. Vogin, M. Maalouf, A. Joubert, N. Foray","doi":"10.1504/IJLR.2011.044191","DOIUrl":"https://doi.org/10.1504/IJLR.2011.044191","url":null,"abstract":"Unrepaired and misrepaired DNA Double-Strand Breaks (DSBs) were shown to be the key events of radiation-induced toxicity (radiosensitivity) and genomic instability (cancer proneness), respectively. We have previously shown that immunofluorescence with γ -H2AX and MRE11 biomarkers may account for unrepaired and misrepaired DSBs for doses higher than 1 Gy. Three radiosensitivity groups had been defined (group I: radioresistance; group II: moderate radiosensitivity and cancer proneness; group III: hyper-radiosensitivity). Here, we investigated X-ray doses ranging from 9 mGy to 2 Gy in three cell lines representative of these radiosensitivity groups. We observed a non-linear dose-dependent increase of the severity of DSB, suggesting a correlation with the phenomenon of hyper-radiosensitivity to low dose; a non-linear dose-dependent increase of MRE11 foci, revealing a dose-threshold for the radiation-induced genomic instability. Altogether, these data document the evidence of a threshold in low-dose response and strongly suggest the impact of individual factor.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"96"},"PeriodicalIF":0.0,"publicationDate":"2011-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.044191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-13DOI: 10.1504/IJLR.2011.044190
L. Feinendegen
Low-dose irradiation of mammalian tissues causes damage and protection, the ratio of which increasingly advances damage as doses increase. Below about 100 mSv, there is no observation of increased cancer incidence in exposed human populations. These data contradict the linear-no-threshold (LNT) dose-risk model. A biological system approach formalises the body to be organised in hierarchical levels. Depending on dose, primary damage to molecules, especially DNA, induces damage and protection that both can propagate through ascending levels and eventually affects the whole body. Even if crude in the face of stochastic patterns of energy depositions in exposed tissues and the enormous complexity of biological systems, the present approach again principally leads to contradict the LNT model in favour of a dose threshold for risk and hormesis in terms of mitigation of both radiogenic and spontaneous oncogenesis, both after acute and protracted low-level exposures, in agreement with experimental and epidemiological data.
{"title":"2010 Marie Curie prize lecture: low-dose induced protection invalidates the linear-no-threshold model in mammalian bodies - a system-biology approach","authors":"L. Feinendegen","doi":"10.1504/IJLR.2011.044190","DOIUrl":"https://doi.org/10.1504/IJLR.2011.044190","url":null,"abstract":"Low-dose irradiation of mammalian tissues causes damage and protection, the ratio of which increasingly advances damage as doses increase. Below about 100 mSv, there is no observation of increased cancer incidence in exposed human populations. These data contradict the linear-no-threshold (LNT) dose-risk model. A biological system approach formalises the body to be organised in hierarchical levels. Depending on dose, primary damage to molecules, especially DNA, induces damage and protection that both can propagate through ascending levels and eventually affects the whole body. Even if crude in the face of stochastic patterns of energy depositions in exposed tissues and the enormous complexity of biological systems, the present approach again principally leads to contradict the LNT model in favour of a dose threshold for risk and hormesis in terms of mitigation of both radiogenic and spontaneous oncogenesis, both after acute and protracted low-level exposures, in agreement with experimental and epidemiological data.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"78"},"PeriodicalIF":0.0,"publicationDate":"2011-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.044190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-13DOI: 10.1504/IJLR.2011.044194
T. Mei, Gen Yang, Weikang Wang, Yugang Wang, Lijun Wu
In this study, a new mechanism model is constructed to fit the experimental data from different radiation quantities. The aim of the study was to construct a comprehensive model that contained all the essential biological mechanisms, such as direct irradiation effects or bystander effects, induced DNA damage, Double-Strand Break (DSB) error-free or error-prone repair and genomic instability, which can influence dose responses at low doses of ionising radiation. Results demonstrate that this new model is reasonably predictive of observed in in vitro experimental data obtained with alpha particles or X-rays, producing the correct shape of complex curves and satisfactory numerical agreement, respectively. On the other hand, the comparison of calculated repair rates with different quantities of irradiation suggests that X-ray induced DSB error-free repair rate is faster than alpha particles. In addition, both the highand low-LET irradiation induced dose-response curves could be fitted with the present model.
{"title":"A computational model for low-dose radiation induced cellular transformation by different radiation quantity","authors":"T. Mei, Gen Yang, Weikang Wang, Yugang Wang, Lijun Wu","doi":"10.1504/IJLR.2011.044194","DOIUrl":"https://doi.org/10.1504/IJLR.2011.044194","url":null,"abstract":"In this study, a new mechanism model is constructed to fit the experimental data from different radiation quantities. The aim of the study was to construct a comprehensive model that contained all the essential biological mechanisms, such as direct irradiation effects or bystander effects, induced DNA damage, Double-Strand Break (DSB) error-free or error-prone repair and genomic instability, which can influence dose responses at low doses of ionising radiation. Results demonstrate that this new model is reasonably predictive of observed in in vitro experimental data obtained with alpha particles or X-rays, producing the correct shape of complex curves and satisfactory numerical agreement, respectively. On the other hand, the comparison of calculated repair rates with different quantities of irradiation suggests that X-ray induced DSB error-free repair rate is faster than alpha particles. In addition, both the highand low-LET irradiation induced dose-response curves could be fitted with the present model.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"135"},"PeriodicalIF":0.0,"publicationDate":"2011-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.044194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-13DOI: 10.1504/IJLR.2011.044195
A. Kotava, A. Sasnouskaya
In this paper, the incidence of the illnesses of blood circulation system (IBCS) among liquidators of the Chernobyl accident living in Belarus is described. The increase of the incidence of the IBCS as a whole was found to be 19.5%, that of hypertensive diseases 52.0%, and that of acute and subsequent myocardial infarction 53.2%. The incidence of cerebral infarction increased by a factor 10. An increase of the incidence of hypertensive diseases and cerebrovascular diseases was observed only among the persons of productive age.
{"title":"Incidence of blood circulation system illnesses among liquidators of Chernobyl accident living in Belarus","authors":"A. Kotava, A. Sasnouskaya","doi":"10.1504/IJLR.2011.044195","DOIUrl":"https://doi.org/10.1504/IJLR.2011.044195","url":null,"abstract":"In this paper, the incidence of the illnesses of blood circulation system (IBCS) among liquidators of the Chernobyl accident living in Belarus is described. The increase of the incidence of the IBCS as a whole was found to be 19.5%, that of hypertensive diseases 52.0%, and that of acute and subsequent myocardial infarction 53.2%. The incidence of cerebral infarction increased by a factor 10. An increase of the incidence of hypertensive diseases and cerebrovascular diseases was observed only among the persons of productive age.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"148"},"PeriodicalIF":0.0,"publicationDate":"2011-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.044195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-13DOI: 10.1504/IJLR.2011.040648
A. Menon, C. Nair
POLY MVA, a commercially available health supplement containing α-lipoic acid palladium complex, was evaluated for its potential to enhance the repair of radiation-induced DNA damage. Treatment of human peripheral blood leukocytes with POLY MVA immediately after radiation exposure enhanced the repair of cellular DNA as revealed by comet assay. Post-irradiation administration of POLY MVA to mice resulted in faster cellular DNA repair, as revealed from the increased Cellular Repair Index (CRI) of blood leukocytes and bone marrow cells. Exposure of mice to 2 Gy whole-body gamma radiation resulted in the formation of strand breaks of cellular DNA of bone marrow cells, and the unrepaired strand breaks eventually lead to the formation of micronuclei in the reticulocytes. Administration of POLY MVA under post-irradiation conditions showed a decrease in the number of micronucleated reticulocytes. Thus, the studies under ex vivo and in vivo conditions revealed that the enhancement of DNA repair could be one of the...
{"title":"POLY MVA – a dietary supplement containing α-lipoic acid palladium complex, enhances cellular DNA repair","authors":"A. Menon, C. Nair","doi":"10.1504/IJLR.2011.040648","DOIUrl":"https://doi.org/10.1504/IJLR.2011.040648","url":null,"abstract":"POLY MVA, a commercially available health supplement containing α-lipoic acid palladium complex, was evaluated for its potential to enhance the repair of radiation-induced DNA damage. Treatment of human peripheral blood leukocytes with POLY MVA immediately after radiation exposure enhanced the repair of cellular DNA as revealed by comet assay. Post-irradiation administration of POLY MVA to mice resulted in faster cellular DNA repair, as revealed from the increased Cellular Repair Index (CRI) of blood leukocytes and bone marrow cells. Exposure of mice to 2 Gy whole-body gamma radiation resulted in the formation of strand breaks of cellular DNA of bone marrow cells, and the unrepaired strand breaks eventually lead to the formation of micronuclei in the reticulocytes. Administration of POLY MVA under post-irradiation conditions showed a decrease in the number of micronucleated reticulocytes. Thus, the studies under ex vivo and in vivo conditions revealed that the enhancement of DNA repair could be one of the...","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"42-54"},"PeriodicalIF":0.0,"publicationDate":"2011-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.040648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-13DOI: 10.1504/IJLR.2011.040645
M. F. Eissa
The optical properties of CR-39 polymer track detectors irradiated with high Linear Energy Transfer (LET) (alpha particles at energies 3.05 MeV and 4.86 MeV) and followed by low LET (gamma ray irradiation at different doses ranging from 0 to 200 kGy) were investigated. The chemical etching was verified for all samples. Also, the optical properties were studied with an Ultraviolet-Visible (UV-VIS) spectrophotometer for the samples before and after etching. An absorption peak appeared at 208 nm in the UV spectra for the 4.86 MeV samples before etching. On the other hand, the track diameter measurements were satisfied for all samples. Moreover, the optical energy band gap was calculated for the samples before etching. The IR spectra for CR39 samples (before etching and after 3 h etching time) were investigated. All of the three techniques may reveal the formation of new energy levels induced by radiations in CR-39 polymeric material. This study gives a possibility to using the CR-39 samples as a gamma ray dosimeter by the corresponding optical properties.
{"title":"Study of the effect of post-irradiation with low linear energy transfer on optical and spectral response of CR-39 polymeric material","authors":"M. F. Eissa","doi":"10.1504/IJLR.2011.040645","DOIUrl":"https://doi.org/10.1504/IJLR.2011.040645","url":null,"abstract":"The optical properties of CR-39 polymer track detectors irradiated with high Linear Energy Transfer (LET) (alpha particles at energies 3.05 MeV and 4.86 MeV) and followed by low LET (gamma ray irradiation at different doses ranging from 0 to 200 kGy) were investigated. The chemical etching was verified for all samples. Also, the optical properties were studied with an Ultraviolet-Visible (UV-VIS) spectrophotometer for the samples before and after etching. An absorption peak appeared at 208 nm in the UV spectra for the 4.86 MeV samples before etching. On the other hand, the track diameter measurements were satisfied for all samples. Moreover, the optical energy band gap was calculated for the samples before etching. The IR spectra for CR39 samples (before etching and after 3 h etching time) were investigated. All of the three techniques may reveal the formation of new energy levels induced by radiations in CR-39 polymeric material. This study gives a possibility to using the CR-39 samples as a gamma ray dosimeter by the corresponding optical properties.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2011-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.040645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-13DOI: 10.1504/IJLR.2011.040646
G. G. Nair, C. Nair
Sesamol (3,4-methylene dioxyphenol) protected mice from adverse effects of whole body gamma-irradiation. Studies indicated that oral administration of sesamol (SM), 1 hour prior to whole body gamma-irradiation (2–6 Gy), significantly protected cellular DNA in various tissues of mice, as evident from alkaline comet assay. Whole body exposure of mice to a sublethal dose of 6 Gy gamma radiation resulted in oxidative damage in various tissues of mice, and radiation-induced peroxidative damage and depletion of antioxidants such as GSH, GPx in tissues such as liver, kidney and brain. Administration of SM prior to radiation exposure resulted in prevention of radiation-induced peroxidation of membrane lipids and depletion of cellular antioxidants in these tissues. The administration of SM significantly reduced the mortality of the animals following exposure to a lethal dose of 10 Gy whole body gamma-radiation and improved the recovery of the body weight. Thus the studies suggest that oral administration of SM cou...
{"title":"Amelioration of γ -radiation induced genomic insult and oxidative stress in whole body irradiated Swiss albino mice by sesamol","authors":"G. G. Nair, C. Nair","doi":"10.1504/IJLR.2011.040646","DOIUrl":"https://doi.org/10.1504/IJLR.2011.040646","url":null,"abstract":"Sesamol (3,4-methylene dioxyphenol) protected mice from adverse effects of whole body gamma-irradiation. Studies indicated that oral administration of sesamol (SM), 1 hour prior to whole body gamma-irradiation (2–6 Gy), significantly protected cellular DNA in various tissues of mice, as evident from alkaline comet assay. Whole body exposure of mice to a sublethal dose of 6 Gy gamma radiation resulted in oxidative damage in various tissues of mice, and radiation-induced peroxidative damage and depletion of antioxidants such as GSH, GPx in tissues such as liver, kidney and brain. Administration of SM prior to radiation exposure resulted in prevention of radiation-induced peroxidation of membrane lipids and depletion of cellular antioxidants in these tissues. The administration of SM significantly reduced the mortality of the animals following exposure to a lethal dose of 10 Gy whole body gamma-radiation and improved the recovery of the body weight. Thus the studies suggest that oral administration of SM cou...","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2011-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.040646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-13DOI: 10.1504/IJLR.2011.040644
S. Mortazavi, M. Atefi, P. Roshan-shomal, N. Raadpey, G. Mortazavi
The haemostatic effect of burned radioactive lantern mantles powder is investigated. Forty one male Wistar rats were divided randomly into three groups. Following anaesthesia, animals’ tails were cut off. The volume of blood loss, bleeding time and clotting time in control animals were 4.07 ± 1.69 cc, 127.73 ± 44.98 sec and 107.27 ± 51.11 sec, respectively. In the second group, the animals were treated with a non-radioactive lantern mantle, and these figures were 2.34 ± 0.70 cc, 54.50 ± 8.75 sec and 22.9 ± 15.34 sec, respectively. In the third group, the animals were treated with a radioactive lantern mantle, and these figures were 1.54 ± 1.69 cc, 39.54 ± 44.98 sec and 36.62 ± 51.11 sec, respectively. These results clearly show significant alterations in the volume of blood loss, as well as the bleeding or clotting time, following the topical use of the non-radioactive and radioactive lantern mantle powder.
{"title":"Is there any difference between haemostatic effects of non-radioactive and radioactive lantern mantle powder?","authors":"S. Mortazavi, M. Atefi, P. Roshan-shomal, N. Raadpey, G. Mortazavi","doi":"10.1504/IJLR.2011.040644","DOIUrl":"https://doi.org/10.1504/IJLR.2011.040644","url":null,"abstract":"The haemostatic effect of burned radioactive lantern mantles powder is investigated. Forty one male Wistar rats were divided randomly into three groups. Following anaesthesia, animals’ tails were cut off. The volume of blood loss, bleeding time and clotting time in control animals were 4.07 ± 1.69 cc, 127.73 ± 44.98 sec and 107.27 ± 51.11 sec, respectively. In the second group, the animals were treated with a non-radioactive lantern mantle, and these figures were 2.34 ± 0.70 cc, 54.50 ± 8.75 sec and 22.9 ± 15.34 sec, respectively. In the third group, the animals were treated with a radioactive lantern mantle, and these figures were 1.54 ± 1.69 cc, 39.54 ± 44.98 sec and 36.62 ± 51.11 sec, respectively. These results clearly show significant alterations in the volume of blood loss, as well as the bleeding or clotting time, following the topical use of the non-radioactive and radioactive lantern mantle powder.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"8 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2011-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2011.040644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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