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Study of the relationship between geometric isomerism and biologically active properties of compounds 化合物几何同分异构与生物活性关系的研究
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-405-414
A. G. Gasanov, I. G. Ayyubov, G. E. Hajiyeva, F. S. Qurbanova
The results of the research in the field of studying the relationship of the geometric structure of organic compounds with their biological activity are presented. It has been shown that the stereospecific structure of organic and inorganic molecules can have a direct effect on the biologically active properties of substances. Among the known types of stereoisomerism (geometric and optical), this work summarizes the effect of various types of geometric isomerism on the bioactivity of compounds. In addition, the results of the authors’ own research are presented. In particular, the results of studying the antimicrobial and antifungal activity of hydroxyalkyl monoesters of norbornedicarboxylic acid depending on their stereoisomeric forms in relation to various pathogenic microorganisms are shown. The studies were carried out by the serial dilution method. As nutrient media, we used MPA pH 7,2–7,4 for bacteria and Sabouraud’s medium for fungi. The incubation time in a thermostat for bacteria was 18–24 hours at 37ºC, for fungi 1–10 days at 28ºC. It has been noted that the endo-isomers of the synthesized compounds have a higher antimicrobial and antifungal activity against grampositive (Staphylococcus aureus), gramnegative (Escherichia coli, Pseudomonas aeruginosa) bacteria, as well as yeast-like fungi of the genus Candida. Based on the obtained test reports, the synthesized compounds have been recommended for use as local antiseptic preparations.
介绍了有机化合物几何结构与生物活性关系研究领域的研究成果。研究表明,有机和无机分子的立体定向结构对物质的生物活性有直接的影响。在已知的立体异构类型(几何和光学)中,本文综述了不同类型的几何异构对化合物生物活性的影响。此外,还介绍了作者自己的研究成果。特别是,对降冰片二羧酸羟烷基单酯的抗菌和抗真菌活性的研究结果取决于其与各种病原微生物的立体异构体形式。研究采用串联稀释法进行。细菌培养基选用MPA pH为7,2 - 7,4,真菌培养基选用Sabouraud培养基。细菌在恒温器中37℃的孵育时间为18-24小时,真菌在28℃的孵育时间为1-10天。已经注意到,合成的化合物的内切异构体对革兰氏阳性(金黄色葡萄球菌),革兰氏阴性(大肠杆菌,铜绿假单胞菌)细菌以及念珠菌属酵母样真菌具有较高的抗菌和抗真菌活性。根据获得的测试报告,所合成的化合物已被推荐用作局部防腐制剂。
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引用次数: 0
The Genus Alchemilla L. (Rosaceae) in the Flora of Chuvashia 标题楚瓦希亚植物区系中的炼金属(蔷薇科)
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-421-433
A. Chkalov, M. M. Gafurova
In the flora of the Chuvash Republic, 40 species of the genus are revealed. 11 of these (A. altaica, А. argutiserrata, A. barbulata, A. cheirochlora, A. exilis, A. gibberulosa, A. hebescens, A. oxyodonta, A. plicata, A. sibirica, A. vorotnikovii) are registered in the Republic for the first time. Earlier, two species (A. pustynensis Czkalov and A. obtusa auct. non Buser) were noted here erroneously. Species are revealed whose richness corresponds to the level seen in neighbouring regions and approaches the maximum possible. Species richness of the botanicalgeographical areas differs crucially between forest (20–27) and other (steppe/steppefied/outwash) landscapes (2–11) species.
在楚瓦什共和国的植物区系中,发现了40种该属植物。其中11种(A. altaica, А)。argutiserrata、barbulata、cheirochlora、exilis、gibberulosa、a.hebescens、a.oxyodonta、a.plicata、a.sibirica、a.vorotnikovii)首次在共和国登记。在此之前,两个物种(A. pustynensis Czkalov和A. obtusa)被发现。non Buser)在这里被错误地标注了。物种的丰富度与邻近地区的水平相对应,并接近可能的最大值。植物地理区域的物种丰富度在森林(20-27)和其他(草原/草原化/水冲)景观(2-11)物种之间存在显著差异。
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引用次数: 0
Vegetation of the natural monument “Urochishche Kuzilinka” and its surroundings (Orel region) 奥廖尔地区“乌鲁奇什什库兹林卡”自然纪念地及其周边植被
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-434-449
E. Averinova, M. Kazakova, Anastasia S. Kugusheva, Nikolai A. Sobolev
The article describes the calciphytic steppe communities located in the territory of the natural monument “Urochische Kuzilinka” and its surroundings (Orel region). The communities were assigned to the association Onosmato simplicissimae–Salvietum nutantis Averinova ass. nov. That unit was included in the sub-union Bupleuro falcati–Gypsophilenion altissimae Averinova 2005 (union Festucion valesiacae Klika 1931, order Festucetalia valesiacae Soó 1947, class Festuco–Brometea Br.-Bl. et Tx. ex Soó 1947) on the basis of a diagnostic species analysis. The new association was characterized. Results of the ordination analysis of leading environmental factors for the described communities are provided.
本文描述了位于天然纪念碑“Urochische Kuzilinka”及其周边地区(奥廖尔地区)的钙化草原群落。该群落归属于小野樱杂木群落-野樱杂木群落(Onosmato simplicismaae - salvietum nutantis Averinova ass11 . 11)亚群2005 (union festion valesiacae Klika 1931, Festucetalia valesiacae Soó 1947, Festuco-Brometea Br.-Bl)。et txt . ex Soó 1947)在诊断种分析的基础上。这个新协会有其特点。给出了主要环境因子的协调分析结果。
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引用次数: 0
Study of the diffusion process in films sodium salt of carboxymethyl cellulose – drug 羧甲基纤维素钠盐-药物在薄膜中的扩散过程研究
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-382-390
A. Shurshina, E. Kulish
The transport properties of medicinal films based on sodium salt of carboxymethylcellulose and the antibiotic amikacin sulfate have been studied in this work. It has been shown that the process of sorption of water vapor by such films and the release of a drug from them proceeds in an abnormal diffusion mode, which is explained by the slowdown of relaxation processes in glassy polymers, which include the sodium salt of carboxymethylcellulose. An increase of the amount of the introduced drug is accompanied by a regular decrease in the diffusion coefficients of both the process of sorption of water vapor and the release of amikacin from the films. It is noted that the formed films of sodium salt of carboxymethylcellulose-amikacin sulfate dissolve in water during the day and do not provide a prolonged release of the drug. To reduce the solubility of the films in water, the surface modification of the polymer film with calcium chloride has been carried out. It has been found that the modification does not lead to a change in the diffusion mode, but is accompanied by a regular change in the diffusion coefficients – the longer the formed films were kept in a calcium chloride solution, the lower the diffusion coefficients of the sorption of water vapor by medicinal films and the diffusion coefficients of the release of the drug amikacin from the film. It is argued that the surface modification of polymer films based on the sodium salt of carboxymethylcellulose is an effective way of imparting to them the effect of prolonging the release of a drug.
本文研究了羧甲基纤维素钠盐和抗生素硫酸阿米卡星为基材的药膜的传输特性。研究表明,这种薄膜对水蒸气的吸附和药物的释放过程是以一种异常的扩散模式进行的,这可以用玻璃状聚合物(包括羧甲基纤维素的钠盐)弛豫过程的减慢来解释。随着引入药物量的增加,薄膜中水蒸气的吸附和阿米卡星释放的扩散系数都有规律地减小。值得注意的是,羧基甲基纤维素-阿米卡星硫酸钠盐形成的薄膜在白天溶解于水中,并且不提供药物的长时间释放。为了降低聚合物膜在水中的溶解度,用氯化钙对聚合物膜进行了表面改性。结果表明,改性不会改变膜的扩散方式,但会引起膜的扩散系数有规律的变化——膜在氯化钙溶液中保存的时间越长,药膜对水蒸气的吸附扩散系数和药物阿米卡星从膜中释放的扩散系数越小。认为以羧甲基纤维素钠盐为基料对聚合物膜进行表面改性是使其具有药物缓释作用的有效途径。
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引用次数: 0
The structure of productivity elements of durum wheat varieties of Saratov selection 萨拉托夫选育硬粒小麦品种生产力要素结构
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-450-456
E. G. Hachaturov, V. V. Korobko
The objects of the study were plants of 14 varieties of durum wheat Triticum durum Desf., permitted for use at different times in the period from 1975 to 2014. An analysis of the elements of ear productivity in durum wheat plants of Saratov varieties under the conditions of 2020 was carried out. The varietal features of the development of the spike of the main shoot were revealed according to a number of characteristics: the number of spikelets in a spike, the number of grains in an ear, the weight of a grain, the number of ungrained and grained spikelets. The height of the plant and the length of the spike were measured. On the basis of the data obtained, the selection indices were calculated – the Canadian index, the Mexican index, the index of the linear density of the ear, the morphogenetic index of productivity. A cultivar with a balanced type of morphogenetic systems was revealed in terms of the elements of ear productivity – the number of spikelets, the number of caryopses and their weight – Luch 25. This cultivar is characterized by the most developed embryonic shoot among the studied cultivars, as well as the maximum length of the embryonic root system and a high growth rate root system of the seedling.
以14个硬粒小麦品种(Triticum durum Desf)为研究对象。在1975年至2014年期间的不同时间被允许使用。对2020年条件下萨拉托夫品种硬粒小麦穗产量要素进行了分析。根据穗粒数、穗粒数、粒重、无粒和有粒小穗数等性状揭示了主枝穗发育的品种特征。测量了植株的高度和穗的长度。在此基础上,计算了选育指标——加拿大指数、墨西哥指数、穗线密度指数、生产力形态发生指数。从穗产量要素(颖花数、颖果数和颖果重)来看,发现了一个形态发生系统平衡的品种。该品种胚芽最发达,胚根长度最大,幼苗根系生长速度快。
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引用次数: 0
Reuse of a purified solution of cetyltrimethylammonium bromide for the synthesis of gold nanorods 十六烷基三甲基溴化铵纯化溶液在金纳米棒合成中的再利用
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-391-398
Y. D. Gudova, V. Kochubey, A. Skaptsov
We investigate the possibility of reusing CTAB solutions for repeated synthesis of gold nanorods. Three tasks have been solved. The first task is to clean the growth solutions from gold nanorods. The second task is to develop a method using a purified cetyltrimethylammonium bromide solution for repeated synthesis of gold nanorods with the same optical properties as in the initial synthesis. The third task is to test the possibility of management of the optical properties of nanorods during repeated synthesis. The polydispersity of nanorods has been estimated by form factor using developed mathematical model.
我们研究了重复使用CTAB溶液来重复合成金纳米棒的可能性。已经解决了三项任务。第一个任务是从金纳米棒上清洗生长溶液。第二个任务是开发一种使用纯化的十六烷基三甲基溴化铵溶液重复合成具有与初始合成相同光学性质的金纳米棒的方法。第三个任务是测试在重复合成过程中管理纳米棒光学特性的可能性。利用已建立的数学模型,通过形状因子对纳米棒的多分散性进行了估计。
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引用次数: 0
Economic and biological characteristics of the biotypical composition of spring wheat varieties 春小麦品种生物典型组成的经济和生物学特性
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-457-465
I. S. Brailova, Natalya I. Yurieva, Y. Belousova
The aim of this work is to study the component composition and intravarietal polymorphism of storage proteins of three soft and one hard varieties of spring wheat and their relationship with a complex of economically valuable traits. The studies were carried out in 2018–2020 by the department of genetics and immunity at the institute, in the conditions of the southeast of the Central Black Earth Region. In the course of the work, the identification of gliadin biotypes was carried out by electrophoresis in 6.5% polyacrylamide gel, the results of which revealed that the genome of the studied varieties contains: Chernozemnouralskaya 2 (5 biotypes), Voronezh 18 (5 biotypes), Voronezh 20 (4 biotypes) and a solid variety Voronezhskaya 13 (1 biotype). The selected biotypes were propagated for 3 years, analyzed and evaluated according to the indicators of the structural analysis of the elements of productivity and quality. Based on this, their economic and biological characteristics were given. It was found that biotypes 3 and 4 of the Chernozemnouralskaya variety 2, biotypes 1 and 2 of the Voronezhskaya 18 variety, biotypes 1 and 2 of the Voronezhskaya 20 variety proved to be the most productive relative to the standard during the study period. As for the quality indicators, as a result of the research the difference in quality of gliadin biotypes was revealed, which is important to take into account in breeding work to increase genetic diversity when creating high-quality varieties. The ones with the best quality were: biotype 1 of the Chernozemnouralskaya variety 2, biotypes 2 and 3 of the Voronezhskaya 18 variety. The best biotypes, distinguished by a complex of economically valuable traits, which differ from the initial variety, can be used in further breeding work for the accelerated creation of highly productive and high-quality spring wheat varieties.
本研究旨在研究3个软硬品种春小麦的贮藏蛋白组分组成和叶面内多态性及其与一系列经济价值性状的关系。这些研究是在2018-2020年由该研究所遗传和免疫系在中部黑土地区东南部的条件下进行的。在工作过程中,采用6.5%聚丙烯酰胺凝胶电泳技术对麦胶蛋白进行了生物型鉴定,结果表明,所研究品种的基因组包含:Chernozemnouralskaya 2(5个生物型)、Voronezh 18(5个生物型)、Voronezh 20(4个生物型)和固体品种Voronezhskaya 13(1个生物型)。选育3年,按产量和品质要素结构分析指标进行分析评价。在此基础上,给出了它们的经济特性和生物学特性。结果表明,在研究期间,品种2的3型和4型、品种18的1型和2型、品种20的1型和2型相对于标准产量最高。在质量指标方面,研究结果揭示了麦胶蛋白生物型的质量差异,这对育种工作中增加遗传多样性、培育优质品种具有重要意义。品质最好的品种为:Chernozemnouralskaya品种2的生物型1、Voronezhskaya 18的生物型2和3。最好的生物型具有不同于初始品种的具有经济价值的综合性状,可用于进一步的育种工作,以加速创造高产优质的春小麦品种。
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引用次数: 0
Synthesis and study of some properties of colloidal quantum dots of indium antimonide 锑化铟胶体量子点的合成及一些性能研究
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-378-381
O. Y. Tsvetkova, S. N. Shtykov, N. D. Zhukov, T. D. Smirnova
Colloidal quantum dots of indium antimonide have been synthesized by a known technique. The shape and average diameters of quantum dots have been investigated by transmission electron microscopy using a transmission microscope. Controlling the size and shape of colloidal QDs provides information on the formation of the crystal structure of nanoparticles and their possible physical and optical properties. It has been found that InSb quantum dots are characterized by a polygonal shape. The results obtained for QDs correspond to the crystal lattice system of a semiconductor with a cubic crystal lattice structure. Elemental analysis of nanoparticles has been monitored by X-ray microanalysis. The experimental determination error was no more than one percent. The percentages of indium and antimony in QDs according to X-ray microanalysis data corresponded to the theoretical stoichiometry In: Sb = 1:1. Impurities of other elements constituted the level of trace amounts, which confirmed the chemical purity of the synthesized InSb QDs. The fluorescent properties of indium antimonide nanoparticles have been studied. It has been found that the luminescence intensity of InSb nanoparticles at room temperature is insignificant, which is in agreement with the literature data. The quantum yield does not exceed 1%, and the luminescence maximum lies in the range of 1040 nm.
用已知的方法合成了锑化铟胶体量子点。利用透射电镜研究了量子点的形状和平均直径。控制胶体量子点的大小和形状为纳米粒子晶体结构的形成及其可能的物理和光学性质提供了信息。已经发现InSb量子点具有多边形形状的特征。量子点的结果与具有立方晶格结构的半导体晶格系统相对应。纳米粒子的元素分析已被x射线微量分析监测。实验测定误差不超过百分之一。根据x射线微量分析数据,量子点中铟和锑的百分比符合理论化学计量in: Sb = 1:1。其他元素的杂质均达到微量水平,证实了合成的InSb量子点的化学纯度。研究了锑化铟纳米颗粒的荧光性质。研究发现,InSb纳米粒子在室温下的发光强度不显著,这与文献数据一致。量子产率不超过1%,发光最大值在1040nm范围内。
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引用次数: 0
Influence of Amanita muscaria (class Agaricomycetes, fam. Amanitaceae) and Flammulina velutipes (class Agaricomycetes, fam. Physalacriaceae) on the growth and development of seedlings of Picea abies (class Pinophyta, fam. Pinaceae) and Abies sibirica (class Pinophyta, fam. Pinaceae) 毒伞菌(真菌纲)的影响。锦葵科)和金针菇(金针菇纲,fam)。对云杉(Pinophyta纲,fam)幼苗生长发育的影响。松科)和西伯利亚冷杉(松植物纲,科)。松科)
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-415-420
Railia G. Kalyakina, G. T. Bastaeva, E. M. Anhalt, V. A. Simonenkova, O. Lyavdanskaya
The article presents studies of the influence of Amanita muscaria and Flammulina velutipes on the growth and development of seedlings of species of the Pinaceae family. The positive effect of mycorrhization by these fungi species on the growth and development of Picea abies and Abies sibirica was established. Thus, the presence of Flammulina velutipes and Amanita muscaria in the substrate accelerated the appearance of the first shoots by 4–8 days. Mycorrhization of Amanita muscaria influenced the morphometry of the seedlings of Picea abies and Abies sibirica. The main root length changed: in Picea abies it increased by 17.2%, in Abies sibirica it decreased by 12.9%, compared with the control group. In the presence of Amanita muscaria, the length of lateral roots increased by 51.0% in Picea abies seedlings, and by 32.4% in Abies sibirica seedlings, compared with the control group. The height of the aerial part in the presence of Flammulina velutipes increased in comparison with the control group in Picea abies seedlings by 52.2% and in Abies sibirica seedlings by 18.3%. Mycorrhization of Amanita muscaria seedlings caused an increase in the stem diameter at the root collar of Picea abies seedlings by 13.6%, and Abies sibirica seedlings by 12.1%.
本文研究了毒伞和金针菇对松科植物幼苗生长发育的影响。这些真菌对冷杉和西伯利亚冷杉的生长发育具有积极的菌根作用。因此,金针菇和毒伞菌在基质中的存在使第一批芽的出现提前了4-8天。毒伞菌根对云杉和西伯利亚冷杉幼苗形态的影响。与对照组相比,冷杉主根长度增加了17.2%,西伯利亚冷杉主根长度减少了12.9%。毒伞菌存在时,云杉幼苗侧根长度比对照组增加51.0%,西伯利亚冷杉幼苗侧根长度比对照组增加32.4%。金针菇的存在使云杉和西伯利亚冷杉幼苗的地上部高度分别比对照组提高了52.2%和18.3%。毒伞菌根使云杉(Picea abies)和西伯利亚冷杉(abies sibirica)根颈处茎粗分别增加13.6%和12.1%。
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引用次数: 0
Accumulation of heavy metals and arsenic with medicinal herbal raw material of common shovel harvested in Voronezh region 沃罗涅日地区普通铲采药材中重金属和砷的积累
Pub Date : 2021-12-16 DOI: 10.18500/1816-9775-2021-21-4-478-487
N. Dyakova
The Voronezh region is traditionally the most important area of crop production and agriculture. The purpose of the research was to study the contamination with heavy metals of medicinal plant raw materials of the Voronezh region using the example of the roots of ordinary burdock, prepared in urbo- and agro-ecosystems, which have various anthropogenic effects on themselves. The accumulation of heavy metals (lead, mercury, cadmium, nickel, copper, zinc, cobalt, chromium) and arsenic in 51 samples of raw materials was studied. By comparing the heavy metal content in the upper soil layers of the region and the content of these elements in the roots of the bladder, it can be assumed that there are significant physiological barriers to the accumulation of ecotoxicants in the roots of the bladder, which is especially noticeable for elements such as lead, mercury, arsenic, cadmium, cobalt and chromium. At the same time, this type of medicinal vegetal raw material is able to selectively concentrate some heavy metals included in the active centers of enzyme systems (copper and zinc). Thus, for an ordinary bladder under conditions of anthropogenic load, an edaphotype is formed, which is as a result of selection in conditions of anthropogenic pollution of the external environment and the manifestation of adaptation to these conditions.
沃罗涅日地区传统上是最重要的农作物生产和农业地区。本研究的目的是研究沃罗涅日地区药用植物原料的重金属污染,以城市和农业生态系统中制备的普通牛蒡根为例,这些植物对自身有各种人为影响。研究了51个原料样品中重金属(铅、汞、镉、镍、铜、锌、钴、铬)和砷的积累情况。通过比较该地区土壤上层重金属含量与膀胱根中这些元素的含量,可以认为生态毒物在膀胱根中积累存在显著的生理障碍,其中铅、汞、砷、镉、钴、铬等元素的积累尤为明显。同时,这类药用植物原料能够选择性地浓缩酶系统活性中心中的一些重金属(铜和锌)。因此,在人为负荷条件下,普通膀胱形成了一种形态,这是在人为污染外部环境条件下的选择和适应这些条件的表现。
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引用次数: 1
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Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology
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