Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758197
Jinseo Hong, H. Sugo, T. Mineta, I. Kakizaki
This paper presents amino-terminated micro pattern transferring onto a mica substrate using polydimethylsiloxane (PDMS) soft stamp and proteoglycan (PG) molecular immobilization. PDMS bump-arrays with ultra-smooth surface were fabricated utilizing anisotropic etched silicon substrate as a mold. Coating and removal of releasing-agents were investigated to improve detachability of PDMS stamp from silicon substrate. Residual releasing-agents on the surface of the PDMS stamp were completely removed by repeated stamping on dummy mica substrates. After the PDMS stamp was immersed into aminopropyltriethoxysilane (APTES) solution, followed by drying with nitrogen gas blowing, APTES molecules on the PDMS stamp were transferred onto mica substrate. After PG solution was deposited onto the APTES transferred mica substrate, the PG molecules were immobilized both inside and outside the APTES transferred pattern. PG molecules with widely spread glycosaminoglycan (GAG) molecules were successfully immobilized inside the APTES pattern due to amino-termination effect whereas PG molecules with no GAG spreading were also adsorbed outside the pattern.
{"title":"Aminosilane patterning on substrate surface by PDMS soft stamp for proteoglycan molecular immobilization","authors":"Jinseo Hong, H. Sugo, T. Mineta, I. Kakizaki","doi":"10.1109/NEMS.2016.7758197","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758197","url":null,"abstract":"This paper presents amino-terminated micro pattern transferring onto a mica substrate using polydimethylsiloxane (PDMS) soft stamp and proteoglycan (PG) molecular immobilization. PDMS bump-arrays with ultra-smooth surface were fabricated utilizing anisotropic etched silicon substrate as a mold. Coating and removal of releasing-agents were investigated to improve detachability of PDMS stamp from silicon substrate. Residual releasing-agents on the surface of the PDMS stamp were completely removed by repeated stamping on dummy mica substrates. After the PDMS stamp was immersed into aminopropyltriethoxysilane (APTES) solution, followed by drying with nitrogen gas blowing, APTES molecules on the PDMS stamp were transferred onto mica substrate. After PG solution was deposited onto the APTES transferred mica substrate, the PG molecules were immobilized both inside and outside the APTES transferred pattern. PG molecules with widely spread glycosaminoglycan (GAG) molecules were successfully immobilized inside the APTES pattern due to amino-termination effect whereas PG molecules with no GAG spreading were also adsorbed outside the pattern.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129275057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758288
Gayathri Pillai, W. Tan, Cheng-Chi Chen, Sheng-Shian Li
This work presents an elaborate analytical analysis and finite element geometry modeling to investigate the Temperature Coefficient of Frequency (TCF) and resonator bandwidth (BW) for different orientations and modes of operation in Lithium Tantalate (LT) MEMS resonators. Optimum cut algorithm is used to find the ideal wafer orientation and the proposed algorithm is cross-verified using Finite Element Method. Length extension mode resonators operating in the fundamental mode transcend the performance of contour mode resonators. LT resonators with a wafer orientation of (90°, 41°, 60°) operating in the fundamental length extension mode yield close to zero TCF and when oriented along (90°, 44°, 60°) it provides a maximum BW of 2.67%. Best values of both BW and TCF can be achieved simultaneously in a very close range of wafer orientation.
{"title":"Modeling of zero TCF and maximum bandwidth orientation for Lithium Tantalate RF MEMS resonators","authors":"Gayathri Pillai, W. Tan, Cheng-Chi Chen, Sheng-Shian Li","doi":"10.1109/NEMS.2016.7758288","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758288","url":null,"abstract":"This work presents an elaborate analytical analysis and finite element geometry modeling to investigate the Temperature Coefficient of Frequency (TCF) and resonator bandwidth (BW) for different orientations and modes of operation in Lithium Tantalate (LT) MEMS resonators. Optimum cut algorithm is used to find the ideal wafer orientation and the proposed algorithm is cross-verified using Finite Element Method. Length extension mode resonators operating in the fundamental mode transcend the performance of contour mode resonators. LT resonators with a wafer orientation of (90°, 41°, 60°) operating in the fundamental length extension mode yield close to zero TCF and when oriented along (90°, 44°, 60°) it provides a maximum BW of 2.67%. Best values of both BW and TCF can be achieved simultaneously in a very close range of wafer orientation.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122251869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758196
Nguyen Manh Hong, B. Thang, P. N. Hong, N. T. Hong, P. H. Khoi, P. N. Minh
Carbon nanotubes (CNTs) are well-known nanomaterials with many excellent properties such as high hardness, high strength, and excellent thermal conductivity. Owing to their very high thermal conductivity (2000 W/m.K compared to thermal conductivity of Ag 419 W/m.K), CNTs become ones of the most suitable nano additives for fabricating the lubricating oils in order to increase the thermal conductivity of lubricating oils, to enhance the efficiency of heat dissipation for the engine, and to improve the performance efficiency of engine. In this work, we present the obtained results on application of the CNTs in lubricating oils for some engines. The results showed that with the addition of CNTs, the thermal conductivity of lubricating oils increase about 15%, this helps improve the efficiency of heat dissipation for the engine. Experimental results show that when using the lubricating oils containing carbon nanotubes, the temperature of engine dropped about 10°C, fuel saving was upto 15% and longevity of lubricating oil increased upto 20,000 km.
{"title":"Carbon nanotubes based lubricating oils for engines","authors":"Nguyen Manh Hong, B. Thang, P. N. Hong, N. T. Hong, P. H. Khoi, P. N. Minh","doi":"10.1109/NEMS.2016.7758196","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758196","url":null,"abstract":"Carbon nanotubes (CNTs) are well-known nanomaterials with many excellent properties such as high hardness, high strength, and excellent thermal conductivity. Owing to their very high thermal conductivity (2000 W/m.K compared to thermal conductivity of Ag 419 W/m.K), CNTs become ones of the most suitable nano additives for fabricating the lubricating oils in order to increase the thermal conductivity of lubricating oils, to enhance the efficiency of heat dissipation for the engine, and to improve the performance efficiency of engine. In this work, we present the obtained results on application of the CNTs in lubricating oils for some engines. The results showed that with the addition of CNTs, the thermal conductivity of lubricating oils increase about 15%, this helps improve the efficiency of heat dissipation for the engine. Experimental results show that when using the lubricating oils containing carbon nanotubes, the temperature of engine dropped about 10°C, fuel saving was upto 15% and longevity of lubricating oil increased upto 20,000 km.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121485240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758315
K. Luo, Yu-Dong Ma, Wen-Hsin Chang, Gwo-Bin Lee
Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification technique which amplifies DNA with high specificity, efficiency and rapidity under isothermal conditions. In this study, a microfluidic droplet-array chip is presented to implement array-based digital LAMP analysis. The proposed microfluidic system can perform the basic operation of droplets including droplet formation, droplet immobilization, LAMP and detection. This is the first time that an emulsion-droplet microfluidic device was used for array-based digital LAMP analysis. When compared to micro-well digital PCR assays, this droplet array-based digital LAMP assay eliminates the constraint on the size of the digitized target, which was determined by the dimension of the micro-wells. Moreover, the employment of hydrodynamic trapping allows for one-droplet-to-one-trap operation. This microfluidic chip may become a promising device for digital LAMP based diagnosis.
{"title":"An integrated array-based emulsion droplet microfluidic device for digital loop-mediated isothermal amplification (LAMP) analysis","authors":"K. Luo, Yu-Dong Ma, Wen-Hsin Chang, Gwo-Bin Lee","doi":"10.1109/NEMS.2016.7758315","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758315","url":null,"abstract":"Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification technique which amplifies DNA with high specificity, efficiency and rapidity under isothermal conditions. In this study, a microfluidic droplet-array chip is presented to implement array-based digital LAMP analysis. The proposed microfluidic system can perform the basic operation of droplets including droplet formation, droplet immobilization, LAMP and detection. This is the first time that an emulsion-droplet microfluidic device was used for array-based digital LAMP analysis. When compared to micro-well digital PCR assays, this droplet array-based digital LAMP assay eliminates the constraint on the size of the digitized target, which was determined by the dimension of the micro-wells. Moreover, the employment of hydrodynamic trapping allows for one-droplet-to-one-trap operation. This microfluidic chip may become a promising device for digital LAMP based diagnosis.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131397922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758207
Y. Guan, Qinghua Zeng, J. Chen, Shengli Ma, Yufeng Jin
Through silicon via (TSV) technology is moving in the direction of miniaturization and multi-functional development, and is considered to be the main way beyond Moore's Law. This paper presents a fine-pitch TSV manufacturing method with self-aligned backside insulation layer opening for three-dimensional (3D) integration. It is characterized by the use of chemical-mechanical polished (CMP) process and deep reactive ion etching (DRIE) process instead of the traditional lithographic process. Through this method, we can guarantee the integrity of the TSV sidewall insulation and eliminate the photolithography process. Low-frequency and high-frequency electrical performance test is conducted in order to characterize its electrical properties and insulation properties.
{"title":"Fabrication and characterization of fine pitch TSV integration with self-aligned backside insulation layer opening","authors":"Y. Guan, Qinghua Zeng, J. Chen, Shengli Ma, Yufeng Jin","doi":"10.1109/NEMS.2016.7758207","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758207","url":null,"abstract":"Through silicon via (TSV) technology is moving in the direction of miniaturization and multi-functional development, and is considered to be the main way beyond Moore's Law. This paper presents a fine-pitch TSV manufacturing method with self-aligned backside insulation layer opening for three-dimensional (3D) integration. It is characterized by the use of chemical-mechanical polished (CMP) process and deep reactive ion etching (DRIE) process instead of the traditional lithographic process. Through this method, we can guarantee the integrity of the TSV sidewall insulation and eliminate the photolithography process. Low-frequency and high-frequency electrical performance test is conducted in order to characterize its electrical properties and insulation properties.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116433387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758261
Liangliang Chen, N. Xi, Bo Song, Yongliang Yang, Zhiyong Sun, Zhanxin Zhou, Yu Cheng, Yirui Wu
The conventional infrared sensors suffer from trade off between sensitivity and cost. The bolometer infrared camera is low resolution and slow speed while the quantum photodetectors are bulky and expensive. In this paper, the novel low dimensional materials carbon nanotube based Schottky barrier structure non cryogenic IR detector was proposed to detect IR irradiance. In order to characterize the photodetector, a testing bench using digital microscope and precise linear stage was used to measure detector performance. The experimental results show the photodetector has negative direction response and positive direction response on right and left side respectively and the maximum photocurrent output depends on the IR irradiance gradient. The proposed measurement method will be applicable for 1D/2D nanoscale material based photodetector characterization.
{"title":"Photoresponse measurement of carbon nanotube based infrared photodetector using digital microscope","authors":"Liangliang Chen, N. Xi, Bo Song, Yongliang Yang, Zhiyong Sun, Zhanxin Zhou, Yu Cheng, Yirui Wu","doi":"10.1109/NEMS.2016.7758261","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758261","url":null,"abstract":"The conventional infrared sensors suffer from trade off between sensitivity and cost. The bolometer infrared camera is low resolution and slow speed while the quantum photodetectors are bulky and expensive. In this paper, the novel low dimensional materials carbon nanotube based Schottky barrier structure non cryogenic IR detector was proposed to detect IR irradiance. In order to characterize the photodetector, a testing bench using digital microscope and precise linear stage was used to measure detector performance. The experimental results show the photodetector has negative direction response and positive direction response on right and left side respectively and the maximum photocurrent output depends on the IR irradiance gradient. The proposed measurement method will be applicable for 1D/2D nanoscale material based photodetector characterization.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"189 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134452865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758208
G. Gutmann, Daisuke Inoue, A. Kakugo, A. Konagaya
With the ever increasing computational demand of scientific research and data analysis, there has been a migration towards GPU computing. GPU are now the primary source of compute power in most top supercomputers. But in order to make use of the power programs must utilize more than a single GPU. Within this paper we will explain various approaches we have taken to utilize multiple GPU, and attempt to reach close to perfect scaling on a multi-step simulation. The result of this is having developed our simulation to be computed on a master and slave setup of GPU. Our simulation mentioned is being developed for the purpose of simulating microtubule dynamics on a gliding assay.
{"title":"Using a master and slave approach for GPGPU computing to achieve optimal scaling in a 3D real-time simulation","authors":"G. Gutmann, Daisuke Inoue, A. Kakugo, A. Konagaya","doi":"10.1109/NEMS.2016.7758208","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758208","url":null,"abstract":"With the ever increasing computational demand of scientific research and data analysis, there has been a migration towards GPU computing. GPU are now the primary source of compute power in most top supercomputers. But in order to make use of the power programs must utilize more than a single GPU. Within this paper we will explain various approaches we have taken to utilize multiple GPU, and attempt to reach close to perfect scaling on a multi-step simulation. The result of this is having developed our simulation to be computed on a master and slave setup of GPU. Our simulation mentioned is being developed for the purpose of simulating microtubule dynamics on a gliding assay.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"42 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128695437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758198
Fikret Yildiz, T. Matsunaga, Y. Haga
This paper reports fabrication of CMUT (Capacitive Micromachined Ultrasonic Transducer) based forward looking ultrasonic endoscope using custom designed LTCC (Low Temperature Co-fired Ceramic). Bottom electrodes and cavities are separately patterned on LTCC and SOI wafers, respectively. LTCC wafer is used as bottom substrate (prime wafer) for anodic bonding and ring array and linear array CMUTs transducers are fabricated. To drive transducer arrays electrical connections between transducer arrays and IC (Integrated Circuits) are achieved by LTCC side via accomplished hexagonal shape dicing of CMUT after fabrication. Design, fabrication process and first fabrication results are presented. The advantages of CMUT packaging using LTCC side via compared to previously announced CMUT probe packaging such as TSV (Through Silicon Via) scheme are discussed.
{"title":"CMUT arrays incorporating anodically bondable LTCC for small diameter ultrasonic endoscope","authors":"Fikret Yildiz, T. Matsunaga, Y. Haga","doi":"10.1109/NEMS.2016.7758198","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758198","url":null,"abstract":"This paper reports fabrication of CMUT (Capacitive Micromachined Ultrasonic Transducer) based forward looking ultrasonic endoscope using custom designed LTCC (Low Temperature Co-fired Ceramic). Bottom electrodes and cavities are separately patterned on LTCC and SOI wafers, respectively. LTCC wafer is used as bottom substrate (prime wafer) for anodic bonding and ring array and linear array CMUTs transducers are fabricated. To drive transducer arrays electrical connections between transducer arrays and IC (Integrated Circuits) are achieved by LTCC side via accomplished hexagonal shape dicing of CMUT after fabrication. Design, fabrication process and first fabrication results are presented. The advantages of CMUT packaging using LTCC side via compared to previously announced CMUT probe packaging such as TSV (Through Silicon Via) scheme are discussed.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122308526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758195
A. Nobori, Naofumi Kobayashi, H. Kuwae, T. Kasahara, J. Oshima, C. Adachi, S. Shoji, J. Mizuno
We propose ribbon type flexible organic light emitting diodes (OLEDs), which can be integrated into textiles, using liquid organic semiconductors (LOSs). A linear flexible microchannel, which consists of a liquid light-emitting layer with LOS sandwiched between two indium tin oxide (ITO) electrodes, was fabricated with photolithography and heterogeneous bonding. LOSs were injected into the SU-8-based linear microchannels of 70 mm in length. Three different colors of photoluminescence (PL) emission were observed from flexible linear microchannels. Liner electroluminescence (EL) emission was successfully obtained in a bending state as well as straight state. We expect that the proposed microfluidic OLED ribbons will have high potential for future free-formable wearable devices such as electronic textiles.
{"title":"Flexible organic light emitting diode ribbons using three liquid organic semiconductors","authors":"A. Nobori, Naofumi Kobayashi, H. Kuwae, T. Kasahara, J. Oshima, C. Adachi, S. Shoji, J. Mizuno","doi":"10.1109/NEMS.2016.7758195","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758195","url":null,"abstract":"We propose ribbon type flexible organic light emitting diodes (OLEDs), which can be integrated into textiles, using liquid organic semiconductors (LOSs). A linear flexible microchannel, which consists of a liquid light-emitting layer with LOS sandwiched between two indium tin oxide (ITO) electrodes, was fabricated with photolithography and heterogeneous bonding. LOSs were injected into the SU-8-based linear microchannels of 70 mm in length. Three different colors of photoluminescence (PL) emission were observed from flexible linear microchannels. Liner electroluminescence (EL) emission was successfully obtained in a bending state as well as straight state. We expect that the proposed microfluidic OLED ribbons will have high potential for future free-formable wearable devices such as electronic textiles.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124377707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758194
Hao Wang, Tao Wang, Chengkuo Lee
Technology for enabling drug delivery with precise control is strongly demanded by patients with diabetes or other chronic diseases. More intelligent functions such as drug loading and delivery in controllable manner without requiring electrical power will make low-cost drug delivery patches come true. One of the promising candidates is triboelectric technology which has been deployed as nanogenerators and self-powered glucose sensors recently. In this paper, the drug delivery is triggered by finger-pressing on a polymer based micropump. Considering that the finger-pressing should be an action of very low frequency, e.g., 1 to 2 Hz, triboelectric energy harvester (TEH) based on contact-separation mode between patterned biocompatible polymer layer and Aluminum (Al) film is integrated with microneedles on a flexible skin patch. Leveraging triboelectric materials and compatible fabrication technology, we successfully develop a self-powered flexible skin patch for transdermal insulin delivery with novel liquid volume sensor to monitor delivered drug volume.
{"title":"Self-powered liquid volume sensor aiming at lab-on-chip applications","authors":"Hao Wang, Tao Wang, Chengkuo Lee","doi":"10.1109/NEMS.2016.7758194","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758194","url":null,"abstract":"Technology for enabling drug delivery with precise control is strongly demanded by patients with diabetes or other chronic diseases. More intelligent functions such as drug loading and delivery in controllable manner without requiring electrical power will make low-cost drug delivery patches come true. One of the promising candidates is triboelectric technology which has been deployed as nanogenerators and self-powered glucose sensors recently. In this paper, the drug delivery is triggered by finger-pressing on a polymer based micropump. Considering that the finger-pressing should be an action of very low frequency, e.g., 1 to 2 Hz, triboelectric energy harvester (TEH) based on contact-separation mode between patterned biocompatible polymer layer and Aluminum (Al) film is integrated with microneedles on a flexible skin patch. Leveraging triboelectric materials and compatible fabrication technology, we successfully develop a self-powered flexible skin patch for transdermal insulin delivery with novel liquid volume sensor to monitor delivered drug volume.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132479122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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