Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758223
Szu-Chin Lei, Wen-Hsuan Hsieh, W. Cheng, Y. Tsai, Che-Hsin Lin
This study develops a novel approach for producing hyperboloid microlens structure directly on a single-mode optical fiber for high performance diode laser coupling. The hyperboloid shape lensed tip is for matching with the rectangular output of the semiconductor laser diode. The hyperboloid lensed fiber is produced a three-step process including a precision mechanical grinding, a spin-on-glass (SOG) coating and an electrostatic pulling process. A flat-end single mode fiber with the core diameter of 6.6 μm is aligned, fixed and grinded into trapezoid shape. Trace amount of spin-on-glass is applied on the grinded tip and then an electrostatic pulling is used to tune the radius of curvature of around 4.5 μm for the grinded tip. A high coupling efficiency around 80% is obtained while using the produced hyperboloid fibers, which is about double compared to the coupling efficiency of the flat end fiber. The measured coupling stability for 5 individual hyperboloid fibers is 0.116±0.044%, indicating the good coupling stability for the produced hyperboloid microlensed fibers. The developed hyperboloid microlensed fibers provides a solution for direct light coupling between the single mold fiber and the semiconductor diode laser.
{"title":"Micro-hyperboloid lensed optical fibers for laser chip coupling","authors":"Szu-Chin Lei, Wen-Hsuan Hsieh, W. Cheng, Y. Tsai, Che-Hsin Lin","doi":"10.1109/NEMS.2016.7758223","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758223","url":null,"abstract":"This study develops a novel approach for producing hyperboloid microlens structure directly on a single-mode optical fiber for high performance diode laser coupling. The hyperboloid shape lensed tip is for matching with the rectangular output of the semiconductor laser diode. The hyperboloid lensed fiber is produced a three-step process including a precision mechanical grinding, a spin-on-glass (SOG) coating and an electrostatic pulling process. A flat-end single mode fiber with the core diameter of 6.6 μm is aligned, fixed and grinded into trapezoid shape. Trace amount of spin-on-glass is applied on the grinded tip and then an electrostatic pulling is used to tune the radius of curvature of around 4.5 μm for the grinded tip. A high coupling efficiency around 80% is obtained while using the produced hyperboloid fibers, which is about double compared to the coupling efficiency of the flat end fiber. The measured coupling stability for 5 individual hyperboloid fibers is 0.116±0.044%, indicating the good coupling stability for the produced hyperboloid microlensed fibers. The developed hyperboloid microlensed fibers provides a solution for direct light coupling between the single mold fiber and the semiconductor diode laser.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126768001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758199
H. Kudo, Keigo Enomoto, Yota Jingushi
A flow injection system using electrochemical biosensor for in-time monitoring of lactic acid at the skin's surface was fabricated and tested. The system consists of a microfluidic `skin-patch' sampling device and an electrochemical biosensor using a carbon graphite electrode. In order to enhance the stability of monitoring, lactic acid excreted at the skin's surface was directly solved into the career flow (phosphate buffered saline) in the `skin-patch' sampling device. Therefore our system measures the amount of lactic acid secretion instead of concentrations of lactic acid in the sweat. The electrodes of the biosensor was modified using osmium wired horseradish peroxidase (Os-HRP) redox polymer. The detection limit of the biosensor for lactic acid was 1.0 μM and the sensitivity was 3.125 μA / mM at 1.0 mM. Real-time monitoring of excreted lactic acid during the stationary bike workout was carried out. The flow injection system was attached on the upper arm of the volunteer. Owing to the `skin-patch' flow-channel, transudation of lactic acid was successfully monitored continuously in real-time with sufficient stability. As a result, the lactic acid level increased during the exercise and decreased to the initial level after the exercise. From this result, the system is expected to be used in sports science field such as scientific sports training.
研制了一种用于皮肤表面乳酸实时监测的电化学生物传感器流动注射系统。该系统由一个微流体“皮肤贴片”采样装置和一个使用碳石墨电极的电化学生物传感器组成。为了增强监测的稳定性，在“皮肤贴片”取样装置中，将皮肤表面排泄的乳酸直接溶解到职业流(磷酸盐缓冲盐水)中。因此，我们的系统测量的是乳酸分泌量，而不是汗液中乳酸的浓度。该生物传感器电极采用锇线辣根过氧化物酶(Os-HRP)氧化还原聚合物修饰。乳酸传感器的检出限为1.0 μM，灵敏度为3.125 μA / mM (1.0 mM)，实时监测运动过程中乳酸的排泄量。流动注射系统安装在志愿者的上臂上。由于“皮肤贴片”流动通道，乳酸的转化成功地连续实时监测，具有足够的稳定性。因此，乳酸水平在运动过程中升高，运动后下降到初始水平。从实验结果来看，该系统有望应用于科学运动训练等体育科学领域。
{"title":"Flow injection system for real-time monitoring of lactic acid at the outer surface of the skin","authors":"H. Kudo, Keigo Enomoto, Yota Jingushi","doi":"10.1109/NEMS.2016.7758199","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758199","url":null,"abstract":"A flow injection system using electrochemical biosensor for in-time monitoring of lactic acid at the skin's surface was fabricated and tested. The system consists of a microfluidic `skin-patch' sampling device and an electrochemical biosensor using a carbon graphite electrode. In order to enhance the stability of monitoring, lactic acid excreted at the skin's surface was directly solved into the career flow (phosphate buffered saline) in the `skin-patch' sampling device. Therefore our system measures the amount of lactic acid secretion instead of concentrations of lactic acid in the sweat. The electrodes of the biosensor was modified using osmium wired horseradish peroxidase (Os-HRP) redox polymer. The detection limit of the biosensor for lactic acid was 1.0 μM and the sensitivity was 3.125 μA / mM at 1.0 mM. Real-time monitoring of excreted lactic acid during the stationary bike workout was carried out. The flow injection system was attached on the upper arm of the volunteer. Owing to the `skin-patch' flow-channel, transudation of lactic acid was successfully monitored continuously in real-time with sufficient stability. As a result, the lactic acid level increased during the exercise and decreased to the initial level after the exercise. From this result, the system is expected to be used in sports science field such as scientific sports training.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116656567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758202
R. C. Gough, Richard C. Ordonez, M. R. Moorefield, K. J. Cho, W. Shiroma, A. Ohta
A new design for a reconfigurable antenna using electrically actuated liquid-metal tuning elements is presented. Liquid-metal slugs vary the electrical length of a resonant slot aperture, changing the operational frequency of the antenna across a 36% tunable bandwidth. The fluidic channels are fabricated with polydimethylsiloxane and are fully sealed with integrated DC actuation pads, providing enhanced versatility over previous designs and enabling future miniaturization.
{"title":"Reconfigurable liquid-metal antenna with integrated surface-tension actuation","authors":"R. C. Gough, Richard C. Ordonez, M. R. Moorefield, K. J. Cho, W. Shiroma, A. Ohta","doi":"10.1109/NEMS.2016.7758202","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758202","url":null,"abstract":"A new design for a reconfigurable antenna using electrically actuated liquid-metal tuning elements is presented. Liquid-metal slugs vary the electrical length of a resonant slot aperture, changing the operational frequency of the antenna across a 36% tunable bandwidth. The fluidic channels are fabricated with polydimethylsiloxane and are fully sealed with integrated DC actuation pads, providing enhanced versatility over previous designs and enabling future miniaturization.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123547207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758292
P. Karthik, Yuma Shimo, Zaw Lin, R. Venkata Krishna Rao, X. Gong, Mitsunobu Yoshida, M. Hada, T. Nishikawa, Y. Hayashi, S. Singh
Here in, we report carbon nanostructures (nanorods) synthesized via liquid-liquid interface precipitation method (LLIP) with its application in field effect transistor as gate terminal. The carbon nanorods were synthesized by supersaturating and shape shifting Bucky ball fullerene into nanorods. The nanoparticles synthesis process is fast, efficient and the reaction is carried out in 24hrs. The obtained nanorods were found to have semiconducting property which was confirmed by analyzing TEM, SEM and RAMAN, FET analysis by IV measurements. Hence the nanorods where fabricated as gate terminal in field effect transistor.
{"title":"Carbon nanostructures synthesized via self-assembly (LLIP) and its application in FET","authors":"P. Karthik, Yuma Shimo, Zaw Lin, R. Venkata Krishna Rao, X. Gong, Mitsunobu Yoshida, M. Hada, T. Nishikawa, Y. Hayashi, S. Singh","doi":"10.1109/NEMS.2016.7758292","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758292","url":null,"abstract":"Here in, we report carbon nanostructures (nanorods) synthesized via liquid-liquid interface precipitation method (LLIP) with its application in field effect transistor as gate terminal. The carbon nanorods were synthesized by supersaturating and shape shifting Bucky ball fullerene into nanorods. The nanoparticles synthesis process is fast, efficient and the reaction is carried out in 24hrs. The obtained nanorods were found to have semiconducting property which was confirmed by analyzing TEM, SEM and RAMAN, FET analysis by IV measurements. Hence the nanorods where fabricated as gate terminal in field effect transistor.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124402266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758236
Guowei Tao, B. Choubey
M/NEMS resonators are widely used as mass sensors. Coupled resonators have emerged as a promising candidate for multifunction sensing while reducing the number of interconnections and pads. Coupling between these sensors enables control and characterization of the entire array by driving/reading from only one element. Inverse eigenvalue analysis utilizes the eigenvalues recorded from the response of one single resonator to inversely reconstruct the system matrix of all resonators. We compare two inverse eigenvalue analysis techniques to characterize coupled M/NEMS resonators. The first technique perturbs the spring constant of one element, while the second couples an additional resonator to the array. Both techniques showed high accuracy in extracting the actual characteristics of a simulated array of resonators. However, when studied for performance in noisy situation, the second technique shows better accuracy. Furthermore, the second technique is easier to implement by using a simple electrical resonator. Inverse eigenvalue analysis can be used to actuate single input single output multifunction sensors and monitor micro/nano fabrication variabilities.
{"title":"Inverse eigenvalue analysis techniques for coupled M/NEMS resonators","authors":"Guowei Tao, B. Choubey","doi":"10.1109/NEMS.2016.7758236","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758236","url":null,"abstract":"M/NEMS resonators are widely used as mass sensors. Coupled resonators have emerged as a promising candidate for multifunction sensing while reducing the number of interconnections and pads. Coupling between these sensors enables control and characterization of the entire array by driving/reading from only one element. Inverse eigenvalue analysis utilizes the eigenvalues recorded from the response of one single resonator to inversely reconstruct the system matrix of all resonators. We compare two inverse eigenvalue analysis techniques to characterize coupled M/NEMS resonators. The first technique perturbs the spring constant of one element, while the second couples an additional resonator to the array. Both techniques showed high accuracy in extracting the actual characteristics of a simulated array of resonators. However, when studied for performance in noisy situation, the second technique shows better accuracy. Furthermore, the second technique is easier to implement by using a simple electrical resonator. Inverse eigenvalue analysis can be used to actuate single input single output multifunction sensors and monitor micro/nano fabrication variabilities.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132367738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758247
C. Chuang, B. Chang, Jian-Ming Chen
Transparent conductive electrodes (TCE) possessing a combination of high optical transmission and good electrical conductivity find applications in numerous optoelectronic devices. In this study, we propose the low cost fabrication of a fine metal mesh structure on rigid (glass) and flexible (PET) substrates as a promising and feasible approach for fulfilling large size TCE requirements. We have utilized a roll-to-sheet assisted ultraviolet imprinting protocol to transfer micro trench structures using a flexible PDMS stamp. The conductive silver ink is filled into the micro trench structures by controlling the processing parameters which include pressure, scraping angle and speed. The metal mesh based glass and PET substrates show a transmission of about 90% while the electrical resistance is as low as 6 Ω/□. Thus, we believe that this method can be utilized as an economically viable alternative to ITO in TCE applications.
{"title":"Transparent metal mesh based on roll to sheet UV imprinting using a PDMS soft mold","authors":"C. Chuang, B. Chang, Jian-Ming Chen","doi":"10.1109/NEMS.2016.7758247","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758247","url":null,"abstract":"Transparent conductive electrodes (TCE) possessing a combination of high optical transmission and good electrical conductivity find applications in numerous optoelectronic devices. In this study, we propose the low cost fabrication of a fine metal mesh structure on rigid (glass) and flexible (PET) substrates as a promising and feasible approach for fulfilling large size TCE requirements. We have utilized a roll-to-sheet assisted ultraviolet imprinting protocol to transfer micro trench structures using a flexible PDMS stamp. The conductive silver ink is filled into the micro trench structures by controlling the processing parameters which include pressure, scraping angle and speed. The metal mesh based glass and PET substrates show a transmission of about 90% while the electrical resistance is as low as 6 Ω/□. Thus, we believe that this method can be utilized as an economically viable alternative to ITO in TCE applications.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123855874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758305
Shih-Chi Chan, D. T. Lin, Kai-Che Liu, Jing-Jim Ou, Ashwin Verma
A flexible MIS(Minimally Invasive Surgery) force feedback sensor is a prospective technology for the extensive application of a Piezoelectric device. The purpose of this study was to know the crystallization of ZnO film for MIS force feedback sensor by sol-gel technology and spin coating. The center of operating frequency of this MIS force feedback sensor was measured by a vector network analyzer. The results showed a significant deviation of frequency resulted from the performance of AlN Doped ZnO. Characteristics of the piezoelectric MIS force feedback sensor are thin, portable and flexible. The improvement of fabricated parameters may enhance the effect of sensing of this MIS force feedback sensor.
{"title":"Fabrication of ZnO thin film sensor for MIS flexible force feedback device","authors":"Shih-Chi Chan, D. T. Lin, Kai-Che Liu, Jing-Jim Ou, Ashwin Verma","doi":"10.1109/NEMS.2016.7758305","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758305","url":null,"abstract":"A flexible MIS(Minimally Invasive Surgery) force feedback sensor is a prospective technology for the extensive application of a Piezoelectric device. The purpose of this study was to know the crystallization of ZnO film for MIS force feedback sensor by sol-gel technology and spin coating. The center of operating frequency of this MIS force feedback sensor was measured by a vector network analyzer. The results showed a significant deviation of frequency resulted from the performance of AlN Doped ZnO. Characteristics of the piezoelectric MIS force feedback sensor are thin, portable and flexible. The improvement of fabricated parameters may enhance the effect of sensing of this MIS force feedback sensor.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116921624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758203
Hemin Zhang, W. Yuan, Jiming Zhong, Honglong Chang
In this paper, we presented the electrostatic tuning functions of the coupling factor for the weakly coupled resonators (WCRs) for the first time. A WCRs system with two mechanical coupled double-ended-tuning-fork (DETF) resonators is designed, fabricated and tested to verify the tuning theory. In consistency with the theoretical expectations, the experimental results show that the coupling factor is in a quadratic function with the bias voltage, and the coupling factor exponentially decays with the relevant geometry parameters. A large tunable range of the coupling factor with the minimum value of ~0.000917 and the maximum value of ~0.00196 is obtained by tuning the bias voltage applied on the WCRs. It lays the foundation for controlling the sensitivity and resolution of the WCRs based sensors.
{"title":"Parametrically tunable coupling factor for the weakly coupled resonators","authors":"Hemin Zhang, W. Yuan, Jiming Zhong, Honglong Chang","doi":"10.1109/NEMS.2016.7758203","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758203","url":null,"abstract":"In this paper, we presented the electrostatic tuning functions of the coupling factor for the weakly coupled resonators (WCRs) for the first time. A WCRs system with two mechanical coupled double-ended-tuning-fork (DETF) resonators is designed, fabricated and tested to verify the tuning theory. In consistency with the theoretical expectations, the experimental results show that the coupling factor is in a quadratic function with the bias voltage, and the coupling factor exponentially decays with the relevant geometry parameters. A large tunable range of the coupling factor with the minimum value of ~0.000917 and the maximum value of ~0.00196 is obtained by tuning the bias voltage applied on the WCRs. It lays the foundation for controlling the sensitivity and resolution of the WCRs based sensors.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129288131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758225
K. B. Vinayakumar, K. Rajanna, N. S. Dinesh, M. Nayak
To improve the transdermal delivery of drug, there are many techniques have been reported (Chemical, Iontophoresis, Sonophoresis and Microneedle). Among these techniques, the microneedle technology gained the more attention in recent years. Mainly, there are two types (Solid and Hollow) of microneedles have been reported for the successful drug delivery application. In this paper, we report on the fabrication of out-of-plane solid Stainless Steel (SS) microneedles and formation of microcup structure within them suitable for drug delivery application. Array of out-of-plane solid SS microneedles were fabricated using Electric Discharge Machining (EDM) method. Subsequently, the microcup structures on the solid SS microneedles were formed using Focused Ion Beam (FIB) technique. The microcup structure on the microneedles acts as a dedicated region to fill the drug, so that the possible drug leakage while inserting the microneedles into the skin can be avoided. The drug filling into the microcup structures was performed using drop coating method. This coating method in combination with cup shaped microneedle array enables to deliver multiple drugs simultaneously in desired proportion.
{"title":"Out-of-plane cup shaped stainless steel microneedle array for drug delivery","authors":"K. B. Vinayakumar, K. Rajanna, N. S. Dinesh, M. Nayak","doi":"10.1109/NEMS.2016.7758225","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758225","url":null,"abstract":"To improve the transdermal delivery of drug, there are many techniques have been reported (Chemical, Iontophoresis, Sonophoresis and Microneedle). Among these techniques, the microneedle technology gained the more attention in recent years. Mainly, there are two types (Solid and Hollow) of microneedles have been reported for the successful drug delivery application. In this paper, we report on the fabrication of out-of-plane solid Stainless Steel (SS) microneedles and formation of microcup structure within them suitable for drug delivery application. Array of out-of-plane solid SS microneedles were fabricated using Electric Discharge Machining (EDM) method. Subsequently, the microcup structures on the solid SS microneedles were formed using Focused Ion Beam (FIB) technique. The microcup structure on the microneedles acts as a dedicated region to fill the drug, so that the possible drug leakage while inserting the microneedles into the skin can be avoided. The drug filling into the microcup structures was performed using drop coating method. This coating method in combination with cup shaped microneedle array enables to deliver multiple drugs simultaneously in desired proportion.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129357543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-17DOI: 10.1109/NEMS.2016.7758262
S. Momose, Kazuaki Karasawa, M. Ushigome, R. Takasu, O. Tsuboi
We have examined a p-type semi-conductor CuBr thin film used for sensor devices that indicates the order of sensitivity to ammonia in parts per billion (ppb). The CuBr thin film also indicates excellent selectivity to ammonia among reductive gases, which additionally suggests its capacity for fast quantification of the order of seconds. Moreover, CuBr thin film can be adapted to a high-sensitivity aldehyde sensor by a surface modification. Since the fabrication process of CuBr thin film is compatible with an ordinal CMOS process, there is a potential for development into highly integrated and low power consumption sensor devices. These properties make CuBr thin film a promising candidate as a gas sensing material for human-breath analysis.
{"title":"Highly selective and sensitive gas sensors for exhaled breath analysis using CuBr thin film","authors":"S. Momose, Kazuaki Karasawa, M. Ushigome, R. Takasu, O. Tsuboi","doi":"10.1109/NEMS.2016.7758262","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758262","url":null,"abstract":"We have examined a p-type semi-conductor CuBr thin film used for sensor devices that indicates the order of sensitivity to ammonia in parts per billion (ppb). The CuBr thin film also indicates excellent selectivity to ammonia among reductive gases, which additionally suggests its capacity for fast quantification of the order of seconds. Moreover, CuBr thin film can be adapted to a high-sensitivity aldehyde sensor by a surface modification. Since the fabrication process of CuBr thin film is compatible with an ordinal CMOS process, there is a potential for development into highly integrated and low power consumption sensor devices. These properties make CuBr thin film a promising candidate as a gas sensing material for human-breath analysis.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116782864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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