Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758297
Ming-Jie Chen, Chia-Hao Huang, K. Lei, Wei-Hung Cheng, Petrus Tang
To investigate the chemosensitivity of T. vaginalis under tested drug, quantification of the density of T. vaginalis is necessary to study its viability. However, because T. vaginalis is suspended in the medium, microscopic quantification is not practical. In this work, impedimetric quantification of T. vaginalis was demonstrated using a biosensor. Investigations of impedance spectrum, sample loading volume, and correction between impedance magnitude and density of T. vaginalis were reported. Results showed the feasibility of the quantification of suspending cells based on impedance measurement technique. With the advantage of microfluidics technology, quantification of suspending cells can be completed in less sample volume (30 μl) and fast response (a few seconds). The present work has high potential to apply for the study of the development of therapeutic drug of T. vaginalis.
{"title":"Impedimetric quantification of the density of suspending Trichomonas vaginalis","authors":"Ming-Jie Chen, Chia-Hao Huang, K. Lei, Wei-Hung Cheng, Petrus Tang","doi":"10.1109/NEMS.2016.7758297","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758297","url":null,"abstract":"To investigate the chemosensitivity of T. vaginalis under tested drug, quantification of the density of T. vaginalis is necessary to study its viability. However, because T. vaginalis is suspended in the medium, microscopic quantification is not practical. In this work, impedimetric quantification of T. vaginalis was demonstrated using a biosensor. Investigations of impedance spectrum, sample loading volume, and correction between impedance magnitude and density of T. vaginalis were reported. Results showed the feasibility of the quantification of suspending cells based on impedance measurement technique. With the advantage of microfluidics technology, quantification of suspending cells can be completed in less sample volume (30 μl) and fast response (a few seconds). The present work has high potential to apply for the study of the development of therapeutic drug of T. vaginalis.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116173936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758277
Tim Schroeder, J. Froemel, Shuji Tanaka, T. Gessner
For the further miniaturization of integrated circuits, the integration of passive components on the chip is one approach. In DC-DC converter applications, the integration of the inductor with high inductivity is one problem. This paper addresses this problem by proposing a new technique for fabricating a multilayer spiral coil that is also useful as part of electromagnetic MEMS (Micro-Electro-Mechanical Systems) actuators. The multilayer coil is made by stacking separately fabricated coil layers and joining them with a selective bonding and debonding technique.
{"title":"Fabrication of a multilayer spiral coil by selective bonding, debonding and MEMS technologies","authors":"Tim Schroeder, J. Froemel, Shuji Tanaka, T. Gessner","doi":"10.1109/NEMS.2016.7758277","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758277","url":null,"abstract":"For the further miniaturization of integrated circuits, the integration of passive components on the chip is one approach. In DC-DC converter applications, the integration of the inductor with high inductivity is one problem. This paper addresses this problem by proposing a new technique for fabricating a multilayer spiral coil that is also useful as part of electromagnetic MEMS (Micro-Electro-Mechanical Systems) actuators. The multilayer coil is made by stacking separately fabricated coil layers and joining them with a selective bonding and debonding technique.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127288580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758232
Weibing Liu, A. Ming, Yaohui Ren, Qiu-lin Tan, W. Ou, Xilong Sun, Weibing Wang, Dapeng Chen, J. Xiong
In this work, a MEMS infrared source applied to compact Non-Dispersive Infrared (NDIR) gas sensor is reported. Compared to other related things, the source coats integrated nanostructure black silicon compatible with CMOS technique on the poly-silicon. Hence the emissivity is as high as 98% at 3~5μm wave range; relatively the radiation efficiency is increased by 40% through calculation. Suspension structure and DRIE release process of the back side are used in the design to reduce the heat conduction losses, and the source is only sized 3×3mm2 suitable for mass production. After being packed, the source can rapidly heat in 20 ms, besides the modulation depth can reach 30% below 50Hz, which all meet the requirements of the NDIR gas sensor.
{"title":"CMOS MEMS infrared source based on black silicon","authors":"Weibing Liu, A. Ming, Yaohui Ren, Qiu-lin Tan, W. Ou, Xilong Sun, Weibing Wang, Dapeng Chen, J. Xiong","doi":"10.1109/NEMS.2016.7758232","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758232","url":null,"abstract":"In this work, a MEMS infrared source applied to compact Non-Dispersive Infrared (NDIR) gas sensor is reported. Compared to other related things, the source coats integrated nanostructure black silicon compatible with CMOS technique on the poly-silicon. Hence the emissivity is as high as 98% at 3~5μm wave range; relatively the radiation efficiency is increased by 40% through calculation. Suspension structure and DRIE release process of the back side are used in the design to reduce the heat conduction losses, and the source is only sized 3×3mm2 suitable for mass production. After being packed, the source can rapidly heat in 20 ms, besides the modulation depth can reach 30% below 50Hz, which all meet the requirements of the NDIR gas sensor.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124170239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758213
G. Sheu, Shao-Ming Yang, Aanand, Syed Sarwar Imam, Ming-Jen Fan, S. Lu
A new double integration-based method to extract model parameters is applied to experimental polysilicon nanowire MOSFETs. It was experimentally found that the saturation current shows the sensitivity of the Nano-wire MOSFETs if the conventional method fails to show the sensitivity depending upon the threshold voltage of Nano-wire MOSFET. It shows that the present method offers advantage over previous extraction procedure which use trans-conductance curve in the saturation mode, and the threshold voltage is determined by the intercept of curve. In addition to show how compact model for the Id-Vg characteristics are numerically evaluated and examined. The drain and gate bias dependencies of device current are shown. Also the model we proposed fits to the silicon data. Our experimental results support the model which we proposed in this paper. The drain current measured in saturation region can easily show the change in current level at different conditions but the convention theory for the linear region is difficult to do for sensitivity test of Nano-wire.
{"title":"An experimental and analytical method to observe the polysilicon Nanowire mosfet threshold voltage","authors":"G. Sheu, Shao-Ming Yang, Aanand, Syed Sarwar Imam, Ming-Jen Fan, S. Lu","doi":"10.1109/NEMS.2016.7758213","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758213","url":null,"abstract":"A new double integration-based method to extract model parameters is applied to experimental polysilicon nanowire MOSFETs. It was experimentally found that the saturation current shows the sensitivity of the Nano-wire MOSFETs if the conventional method fails to show the sensitivity depending upon the threshold voltage of Nano-wire MOSFET. It shows that the present method offers advantage over previous extraction procedure which use trans-conductance curve in the saturation mode, and the threshold voltage is determined by the intercept of curve. In addition to show how compact model for the Id-Vg characteristics are numerically evaluated and examined. The drain and gate bias dependencies of device current are shown. Also the model we proposed fits to the silicon data. Our experimental results support the model which we proposed in this paper. The drain current measured in saturation region can easily show the change in current level at different conditions but the convention theory for the linear region is difficult to do for sensitivity test of Nano-wire.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121993077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758211
Yaqiong Wang, Zhan Yang, Tao Chen, Li-jun Yang, Lining Sun, T. Fukuda
This paper presented a method of picking up carbon nanotubes (CNTs) from nanotube bulk by van der Waals force between the carbon nanotubes and AFM cantilever under scanning electron microscopy (SEM). A manipulation strategy was established based on SEM by analyzing the van der Waals force of three different types of contacting model. Three groups of experiments were designed and carried out to investigate the effects of different factors which conclude pickup angle, pickup contact area between the carbon nanotube and the cantilever and pickup speed of the end-effector. The results shown that a pickup angle at 90.1° and a pickup speed at 10nm/step with a pickup contact length more than 1.5μm would increasing the probability of picking up CNT successfully.
{"title":"CNT handling with van der Waals force inside a SEM for FET application","authors":"Yaqiong Wang, Zhan Yang, Tao Chen, Li-jun Yang, Lining Sun, T. Fukuda","doi":"10.1109/NEMS.2016.7758211","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758211","url":null,"abstract":"This paper presented a method of picking up carbon nanotubes (CNTs) from nanotube bulk by van der Waals force between the carbon nanotubes and AFM cantilever under scanning electron microscopy (SEM). A manipulation strategy was established based on SEM by analyzing the van der Waals force of three different types of contacting model. Three groups of experiments were designed and carried out to investigate the effects of different factors which conclude pickup angle, pickup contact area between the carbon nanotube and the cantilever and pickup speed of the end-effector. The results shown that a pickup angle at 90.1° and a pickup speed at 10nm/step with a pickup contact length more than 1.5μm would increasing the probability of picking up CNT successfully.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124964810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758214
Antti-Juhana Maki, A. Kontunen, Tomi Ryynänen, J. Verho, J. Kreutzer, J. Lekkala, P. Kallio
Gravity-driven flow is an attractive approach to develop simpler microfluidic systems. Because clogged microchannels could easily lead to fatal operational failures, it is crucial to monitor flow rate in these systems. Therefore, we propose here for the first time a numerical model that combines a calorimetric flow sensor and a gravity-driven system. With the validated model, we studied the flow behavior in a gravity-driven system. Furthermore, we were able to improve the sensitivity of the measurement based on simulation results. This demonstrates, how the model could be used as an effective optimization tool in the gravity-driven system including calorimetric flow measurement.
{"title":"Design and simulation of a thermal flow sensor for gravity-driven microfluidic applications","authors":"Antti-Juhana Maki, A. Kontunen, Tomi Ryynänen, J. Verho, J. Kreutzer, J. Lekkala, P. Kallio","doi":"10.1109/NEMS.2016.7758214","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758214","url":null,"abstract":"Gravity-driven flow is an attractive approach to develop simpler microfluidic systems. Because clogged microchannels could easily lead to fatal operational failures, it is crucial to monitor flow rate in these systems. Therefore, we propose here for the first time a numerical model that combines a calorimetric flow sensor and a gravity-driven system. With the validated model, we studied the flow behavior in a gravity-driven system. Furthermore, we were able to improve the sensitivity of the measurement based on simulation results. This demonstrates, how the model could be used as an effective optimization tool in the gravity-driven system including calorimetric flow measurement.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"374 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116626606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758284
Zhengxi Cheng, H. Toshiyoshi
This paper presents a new design of complementary metal-oxide-semiconductor-microelectromechanical systems (CMOS-MEMS) infrared emitter arrays integrated with metamaterial absorbers (MA). The infrared emitter array is a key IR thermal radiation source for gas sensors. The IR emitter arrays are implemented using the standard CSMC 0.5 μm 2P3M CMOS process. Three different shape of micro emitters are designed with 2 different thin film layers stacks, without and with metamaterial absorbers, for each shape. Micro structures are released from Si substrate through the post-CMOS dielectric dry etching and bulk silicon wet etching. Read-in circuit is also integrated with each 8×8 scale emitter array. Steady state thermal responses and dynamic thermal responses are simulated through multi-physics coupling finite element method (FEM), then radiation responses are calculated with a Matlab program based on thermal responses. Emissivity of emitters are also calculated through FEM simulation, which shows that the integration of metamaterial absorbers is an effective way to increases emissivity in both short and long infrared wavebands.
{"title":"Design of CMOS-MEMS infrared emitter arrays","authors":"Zhengxi Cheng, H. Toshiyoshi","doi":"10.1109/NEMS.2016.7758284","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758284","url":null,"abstract":"This paper presents a new design of complementary metal-oxide-semiconductor-microelectromechanical systems (CMOS-MEMS) infrared emitter arrays integrated with metamaterial absorbers (MA). The infrared emitter array is a key IR thermal radiation source for gas sensors. The IR emitter arrays are implemented using the standard CSMC 0.5 μm 2P3M CMOS process. Three different shape of micro emitters are designed with 2 different thin film layers stacks, without and with metamaterial absorbers, for each shape. Micro structures are released from Si substrate through the post-CMOS dielectric dry etching and bulk silicon wet etching. Read-in circuit is also integrated with each 8×8 scale emitter array. Steady state thermal responses and dynamic thermal responses are simulated through multi-physics coupling finite element method (FEM), then radiation responses are calculated with a Matlab program based on thermal responses. Emissivity of emitters are also calculated through FEM simulation, which shows that the integration of metamaterial absorbers is an effective way to increases emissivity in both short and long infrared wavebands.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131158933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758323
Tetsuo Sasaki, T. Tanabe, T. Sakamoto, J. Nishizawa
We have developed a wide frequency tunable Continuous Wave (CW) Terahertz (THz) Signal Generator (SG) on the principle of Difference Frequency Generation (DFG) in a Gallium Phosphide (GaP) crystal. The CW THz SG has the merits of high resolution, high accuracy, wide dynamic range, high stability, high durability, easy operation/maintenance, and low cost. Combining the CW THz SG as a light source with a superconducting Transition Edge Sensor (TES) bolometer cooled by a pulse tube refrigerator, the spectrometer working as a non-stop system could be realized. As we could have increased the THz output power up to 0.1 μW at the sacrifice of lack of frequency resolution, it is now possible to apply a pyroelectric detector or a bolometer camera at room temperature operation for spectrometer or monochromatic imaging. Accurate THz spectrometer could be used for evaluation of organic crystals like as pharmaceuticals. One of the reasons for underutilization of THz spectroscopy is that most of the absorptions observed in THz range are not assigned to vibrational modes. We have developed a technique to clarify them by comparing polarization dependent spectra with Density Function Theory (DFT) calculation results for pharmaceutical single crystals.
{"title":"Continuous Wave Terahertz Signal Generator based on Difference Frequency Generation in Gallium Phosphide crystal and its applications for spectroscopy","authors":"Tetsuo Sasaki, T. Tanabe, T. Sakamoto, J. Nishizawa","doi":"10.1109/NEMS.2016.7758323","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758323","url":null,"abstract":"We have developed a wide frequency tunable Continuous Wave (CW) Terahertz (THz) Signal Generator (SG) on the principle of Difference Frequency Generation (DFG) in a Gallium Phosphide (GaP) crystal. The CW THz SG has the merits of high resolution, high accuracy, wide dynamic range, high stability, high durability, easy operation/maintenance, and low cost. Combining the CW THz SG as a light source with a superconducting Transition Edge Sensor (TES) bolometer cooled by a pulse tube refrigerator, the spectrometer working as a non-stop system could be realized. As we could have increased the THz output power up to 0.1 μW at the sacrifice of lack of frequency resolution, it is now possible to apply a pyroelectric detector or a bolometer camera at room temperature operation for spectrometer or monochromatic imaging. Accurate THz spectrometer could be used for evaluation of organic crystals like as pharmaceuticals. One of the reasons for underutilization of THz spectroscopy is that most of the absorptions observed in THz range are not assigned to vibrational modes. We have developed a technique to clarify them by comparing polarization dependent spectra with Density Function Theory (DFT) calculation results for pharmaceutical single crystals.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114302061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758322
J. Bonitz, Simon Böttger, S. Hermann, S. Schulz, T. Gessner, S. Hartmann, B. Wunderle
In this paper we present a holistic wafer-level manufacturing process for nanoscopic sensor devices based on individualized single-wall carbon nanotubes (SWCNTs) integrated in MEMS. The fabrication technology is demonstrated in detail. Moreover, a first application in form of a MEMS test stage for SWCNT strain and reliability experiments is shown.
{"title":"Wafer-level technology for integration of carbon nanotubes into micro-electro-mechanical systems","authors":"J. Bonitz, Simon Böttger, S. Hermann, S. Schulz, T. Gessner, S. Hartmann, B. Wunderle","doi":"10.1109/NEMS.2016.7758322","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758322","url":null,"abstract":"In this paper we present a holistic wafer-level manufacturing process for nanoscopic sensor devices based on individualized single-wall carbon nanotubes (SWCNTs) integrated in MEMS. The fabrication technology is demonstrated in detail. Moreover, a first application in form of a MEMS test stage for SWCNT strain and reliability experiments is shown.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128583641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-01DOI: 10.1109/NEMS.2016.7758255
S. Sivashankar, Sumeyra Agambayev, U. Buttner, K. Salama
In this paper, we report a simple method to evaluate biocompatibility of solid UV cross-linked resin as a material for microfluidic devices that can be used for biological applications. We evaluated the biocompatibility of the material in two different ways (1) determining if the UV cured resin inhibits the polymerase chain reaction (PCR) and (2) observing agglutination complex formed on the surface of the UV cured resin when anti-CRP antibodies and C- reactive protein (CRP) proteins were allowed to agglutinate. Six different types of 3D printer resins were compared to test the biocompatibility. The study showed that only few among them could be used for fabrication of micro channels and that had least effect on biological molecules that could be used for PCR and protein interactions. Through these studies it is possible to estimate the curing time of various resin and their type of interaction with biomolecules. This study finds importance in on-chip tissue engineering and organ-on-chip applications.
{"title":"Characterization of solid UV curable 3D printer resins for biological applications","authors":"S. Sivashankar, Sumeyra Agambayev, U. Buttner, K. Salama","doi":"10.1109/NEMS.2016.7758255","DOIUrl":"https://doi.org/10.1109/NEMS.2016.7758255","url":null,"abstract":"In this paper, we report a simple method to evaluate biocompatibility of solid UV cross-linked resin as a material for microfluidic devices that can be used for biological applications. We evaluated the biocompatibility of the material in two different ways (1) determining if the UV cured resin inhibits the polymerase chain reaction (PCR) and (2) observing agglutination complex formed on the surface of the UV cured resin when anti-CRP antibodies and C- reactive protein (CRP) proteins were allowed to agglutinate. Six different types of 3D printer resins were compared to test the biocompatibility. The study showed that only few among them could be used for fabrication of micro channels and that had least effect on biological molecules that could be used for PCR and protein interactions. Through these studies it is possible to estimate the curing time of various resin and their type of interaction with biomolecules. This study finds importance in on-chip tissue engineering and organ-on-chip applications.","PeriodicalId":150449,"journal":{"name":"2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"286 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134267982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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