Pub Date : 2025-02-18DOI: 10.1080/10286020.2025.2462610
Mei-Li Li, Kun Pang, Lei Qiao, Zhi-Qiang Guan, Chao-Ju Gong, Song-Tao Li, Zhi-Ming Tang, Yi-Ling Zhang, Ji-Cun Ding
Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis and restrain migration. Explored by whole-transcriptome sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2.
{"title":"Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression.","authors":"Mei-Li Li, Kun Pang, Lei Qiao, Zhi-Qiang Guan, Chao-Ju Gong, Song-Tao Li, Zhi-Ming Tang, Yi-Ling Zhang, Ji-Cun Ding","doi":"10.1080/10286020.2025.2462610","DOIUrl":"https://doi.org/10.1080/10286020.2025.2462610","url":null,"abstract":"<p><p>Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis and restrain migration. Explored by whole-transcriptome sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-21"},"PeriodicalIF":1.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/10286020.2024.2385367
Yuan-Cao Shu , Zhi-Yu Zhang , Xiao-Man Fu , Wei-Lin Zeng , Guo-Lei Zhu , Xiao-Qin Yang , Si-Da Xie , Wei-Hua Wang , Ping Zhao
Four isocoumarin derivatives (1–4) and five phenols (5–9) were obtained from the endophytic fungus Pezicula neosporulosa VDB39, which was isolated from the branches of Vaccinium dunalianum Wight (Ericaceae). Compound 1 is a new derivative of isocoumarin. The structures were elucidated by spectroscopic methods. Single X-ray crystallography confirmed the absolute configuration of compound 1. Additionally, the antiphytopathogenic fungi activity of isocoumarin derivatives (1–4) was evaluated.
{"title":"A new isocoumarin derivative from endophytic fungus Pezicula neosporulosa VDB39 from Vaccinium dunalianum","authors":"Yuan-Cao Shu , Zhi-Yu Zhang , Xiao-Man Fu , Wei-Lin Zeng , Guo-Lei Zhu , Xiao-Qin Yang , Si-Da Xie , Wei-Hua Wang , Ping Zhao","doi":"10.1080/10286020.2024.2385367","DOIUrl":"10.1080/10286020.2024.2385367","url":null,"abstract":"<div><div>Four isocoumarin derivatives (<strong>1–4</strong>) and five phenols (<strong>5–9</strong>) were obtained from the endophytic fungus <em>Pezicula neosporulosa</em> VDB39, which was isolated from the branches of <em>Vaccinium dunalianum</em> Wight (Ericaceae). Compound <strong>1</strong> is a new derivative of isocoumarin. The structures were elucidated by spectroscopic methods. Single X-ray crystallography confirmed the absolute configuration of compound <strong>1</strong>. Additionally, the antiphytopathogenic fungi activity of isocoumarin derivatives (<strong>1–4</strong>) was evaluated.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 267-273"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/10286020.2024.2372390
Xiao-Rong Yin , Zhen Yuan , Wei-Feng Wang , Bing-Yang Zhang , Lu-Qiong Wang , Feng Qiu , Feng Zhao
Boswellia sacra has the properties of activating blood circulation, fixing pain, subduing swelling and promoting muscle growth. However, the anti-inflammatory active ingredients and molecular mechanisms of Boswellia sacra are still not clearly explored. Boswellia sacra was grounded and extracted using 95% ethanol, the extracts were separated by column chromatography preparation to give compounds. Spectral analysis and quantum calculations confirmed the structures of compounds and identified compound 1 as a new compound. Compounds 1–3 showed potent inhibitory activities and their effects on inflammatory mediator NO and inflammatory cytokines were examined by ELISA assay. Furthermore, their modulatory mechanism on inflammatory signal pathways was explored.
乳香具有活血、止痛、消肿和促进肌肉生长的功效。然而，乳香的抗炎活性成分和分子机制仍未得到明确的探索。将乳香磨碎并用 95% 的乙醇提取，提取物经柱层析分离得到化合物。光谱分析和量子计算证实了化合物的结构，并确定化合物 1 为新化合物。通过酶联免疫吸附试验检测了化合物 1-3 对炎症介质 NO 和炎症细胞因子的影响。此外，还探讨了它们对炎症信号通路的调节机制。
{"title":"New cembranoid with potent anti-inflammatory effect isolated from Boswellia sacra by inactivating the NF-κB signaling pathway","authors":"Xiao-Rong Yin , Zhen Yuan , Wei-Feng Wang , Bing-Yang Zhang , Lu-Qiong Wang , Feng Qiu , Feng Zhao","doi":"10.1080/10286020.2024.2372390","DOIUrl":"10.1080/10286020.2024.2372390","url":null,"abstract":"<div><div><em>Boswellia sacra</em> has the properties of activating blood circulation, fixing pain, subduing swelling and promoting muscle growth. However, the anti-inflammatory active ingredients and molecular mechanisms of <em>Boswellia sacra</em> are still not clearly explored. <em>Boswellia sacra</em> was grounded and extracted using 95% ethanol, the extracts were separated by column chromatography preparation to give compounds. Spectral analysis and quantum calculations confirmed the structures of compounds and identified compound <strong>1</strong> as a new compound. Compounds <strong>1</strong>–<strong>3</strong> showed potent inhibitory activities and their effects on inflammatory mediator NO and inflammatory cytokines were examined by ELISA assay. Furthermore, their modulatory mechanism on inflammatory signal pathways was explored.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 249-266"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/10286020.2024.2375291
Xiao-Hui Wang , Peng-Fei Dong , Feng Wang , Lin Zhou
In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-tumor effects in vitro by inhibiting TGF-β/Smad signaling pathway. In addition, in vivo experiments, immunohistochemistry was used to observe the expression of HIF-1α, VEGF and VEGFR-2 in tumor tissues. It was found that schisandrin could significantly improve the immunosuppression induced by 5-Fu and enhance the antitumor effect of 5-Fu. The mechanism may be related to the inhibition of Wnt-1/β-catenin signaling pathway.
{"title":"Schisandrin A can promote the anti-tumor effect of 5-Fu by reversing the immunosuppressive state of the body in rat","authors":"Xiao-Hui Wang , Peng-Fei Dong , Feng Wang , Lin Zhou","doi":"10.1080/10286020.2024.2375291","DOIUrl":"10.1080/10286020.2024.2375291","url":null,"abstract":"<div><div>In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-tumor effects in vitro by inhibiting TGF-β/Smad signaling pathway. In addition, in vivo experiments, immunohistochemistry was used to observe the expression of HIF-1α, VEGF and VEGFR-2 in tumor tissues. It was found that schisandrin could significantly improve the immunosuppression induced by 5-Fu and enhance the antitumor effect of 5-Fu. The mechanism may be related to the inhibition of Wnt-1/β-catenin signaling pathway.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 231-248"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/10286020.2024.2376244
Guo-Qing Sun , Cheng-En Fu , Yang Yang , Xiao-Jian Li , Jia-Yi Ma , Shuai Huang , Xian-Li Zhou , Lin Chen
Three new diterpenoid alkaloids (1, 2, 3) and seventeen known (4–20) compounds were isolated from the whole plant of Delphinium sherriffii Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated for the inhibitory activity of Sf9 cells and compound 5 exhibited the strongest cytotoxicity (IC50 = 8.97 μM) against Sf9 cell line.
{"title":"Diterpenoid alkaloids from Delphinium sherriffii","authors":"Guo-Qing Sun , Cheng-En Fu , Yang Yang , Xiao-Jian Li , Jia-Yi Ma , Shuai Huang , Xian-Li Zhou , Lin Chen","doi":"10.1080/10286020.2024.2376244","DOIUrl":"10.1080/10286020.2024.2376244","url":null,"abstract":"<div><div>Three new diterpenoid alkaloids (<strong>1</strong>, <strong>2</strong>, <strong>3</strong>) and seventeen known (<strong>4–20</strong>) compounds were isolated from the whole plant of <em>Delphinium sherriffii</em> Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated for the inhibitory activity of Sf9 cells and compound <strong>5</strong> exhibited the strongest cytotoxicity (IC<sub>50</sub> = 8.97 μM) against Sf9 cell line.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 143-152"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141599920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/10286020.2024.2373326
Jiang Hu , Ren Ji , Guang-Rong Yang , Tao Lv , Qiang Li , Feng Gao
A chemical investigation on the roots of Aconitum nagarum afforded two undescribed C19-diterpenoid alkaloids nagarumines D and E (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested in vitro for cytotoxic activity against five gastric tumor cell lines. Consequently, compound 2 exhibited some cytotoxicities against several human cancer cell lines with IC50 value less than 20.0 μM.
{"title":"Two new diterpenoid alkaloids from the roots of Aconitum nagarum and their cytotoxic activity","authors":"Jiang Hu , Ren Ji , Guang-Rong Yang , Tao Lv , Qiang Li , Feng Gao","doi":"10.1080/10286020.2024.2373326","DOIUrl":"10.1080/10286020.2024.2373326","url":null,"abstract":"<div><div>A chemical investigation on the roots of <em>Aconitum nagarum</em> afforded two undescribed C<sub>19</sub>-diterpenoid alkaloids nagarumines D and E (<strong>1</strong> and <strong>2</strong>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested <em>in vitro</em> for cytotoxic activity against five gastric tumor cell lines. Consequently, compound <strong>2</strong> exhibited some cytotoxicities against several human cancer cell lines with IC<sub>50</sub> value less than 20.0 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 169-175"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/10286020.2024.2375288
Gao-Jie Li , Chen Wang , Wen-Die Wang , Yue Shang , Chao-Yang Zeng , Ai-Min Wang , Jing-Lin Bai , Jing Su , Ling Su , Shu-Yi Si , Li-Yan Yu , Mao-Luo Gan , Shu-Zhen Chen
Three chromomycin derivatives, chromomycins A3 (1, CA3), A5 (2, CA5), and monodeacetylchromomycin A3 (3, MDA-CA3), were identified from the soil-derived Streptomyces sp. CGMCC 26516. A reinvestigation of the structure of CA5 is reported, of which the absolute configuration was unambiguously determined for the first time to be identical with that of CA3 based on nuclear magnetic resonance (NMR) data analysis as well as NMR and electronic circular dichroism calculations. Compounds 1–3 showed potent cytotoxicity against the non-small-cell lung cancer (NSCLC) cells (A549, H460, H157-c-FLIP, and H157-LacZ) and down-regulated the protein expression of c-FLIP in A549 cells. The IC50 values of chromomycins in H157-c-FLIP were higher than that in H157-LacZ. Furthermore, si-c-FLIP promoted anti-proliferation effect of chromomycins in NSCLC cells. In nude mice xenograft model, 1 and 2 both showed more potent inhibition on the growth of H157-lacZ xenografts than that of H157-c-FLIP xenografts. These results verify that c-FLIP mediates the anticancer effects of chromomycins in NSCLC.
{"title":"Chromomycins from soil-derived Streptomyces sp. inhibit the growth of human non-small cell lung cancer cells by targeting c-FLIP","authors":"Gao-Jie Li , Chen Wang , Wen-Die Wang , Yue Shang , Chao-Yang Zeng , Ai-Min Wang , Jing-Lin Bai , Jing Su , Ling Su , Shu-Yi Si , Li-Yan Yu , Mao-Luo Gan , Shu-Zhen Chen","doi":"10.1080/10286020.2024.2375288","DOIUrl":"10.1080/10286020.2024.2375288","url":null,"abstract":"<div><div>Three chromomycin derivatives, chromomycins A<sub>3</sub> (<strong>1,</strong> CA<sub>3</sub>), A<sub>5</sub> (<strong>2,</strong> CA<sub>5</sub>), and monodeacetylchromomycin A<sub>3</sub> (<strong>3,</strong> MDA-CA<sub>3</sub>), were identified from the soil-derived <em>Streptomyces</em> sp. CGMCC 26516. A reinvestigation of the structure of CA<sub>5</sub> is reported, of which the absolute configuration was unambiguously determined for the first time to be identical with that of CA<sub>3</sub> based on nuclear magnetic resonance (NMR) data analysis as well as NMR and electronic circular dichroism calculations. Compounds <strong>1–3</strong> showed potent cytotoxicity against the non-small-cell lung cancer (NSCLC) cells (A549, H460, H157-c-FLIP, and H157-LacZ) and down-regulated the protein expression of c-FLIP in A549 cells. The IC<sub>50</sub> values of chromomycins in H157-c-FLIP were higher than that in H157-LacZ. Furthermore, si-c-FLIP promoted anti-proliferation effect of chromomycins in NSCLC cells. In nude mice xenograft model, <strong>1</strong> and <strong>2</strong> both showed more potent inhibition on the growth of H157-lacZ xenografts than that of H157-c-FLIP xenografts. These results verify that c-FLIP mediates the anticancer effects of chromomycins in NSCLC.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 153-168"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/10286020.2024.2380744
Xin-Pei Wang , Xue-Hua Li , Jian-Jun Lei , Yu-Wei Xiao , Yang Chi , Qian Sun , He Zhang
Chemical investigation on the 80% EtOH extract of the air dried aerial parts of Hypericum sampsonii resulted in the isolation of two new polycyclic polyprenylated derivatives, hypersampines A and B (1 and 2). The structures of the new compounds were elucidated by spectroscopic data (NMR, IR, and UV) and high resolution mass analysis. The two isolated polyprenylated acylphloroglucinols were tested in vitro for cytotoxic activities against 6 pancreatic cell lines. As a result, compounds 1 and 2 possessed modest cytotoxic activities against all the tested tumor cell lines with IC50 values less than 40 μM.
{"title":"Polyprenylated acylphloroglucinols from Hypericum sampsonii with cytotoxicity against pancreatic carcinomas","authors":"Xin-Pei Wang , Xue-Hua Li , Jian-Jun Lei , Yu-Wei Xiao , Yang Chi , Qian Sun , He Zhang","doi":"10.1080/10286020.2024.2380744","DOIUrl":"10.1080/10286020.2024.2380744","url":null,"abstract":"<div><div>Chemical investigation on the 80% EtOH extract of the air dried aerial parts of <em>Hypericum sampsonii</em> resulted in the isolation of two new polycyclic polyprenylated derivatives, hypersampines A and B (<strong>1</strong> and <strong>2</strong>). The structures of the new compounds were elucidated by spectroscopic data (NMR, IR, and UV) and high resolution mass analysis. The two isolated polyprenylated acylphloroglucinols were tested <em>in vitro</em> for cytotoxic activities against 6 pancreatic cell lines. As a result, compounds <strong>1</strong> and <strong>2</strong> possessed modest cytotoxic activities against all the tested tumor cell lines with IC<sub>50</sub> values less than 40 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 136-142"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/10286020.2024.2385365
Qazi Mohammad Sajid Jamal , Varish Ahmad
An imbalanced microbiome is linked to several diseases, such as cancer, inflammatory bowel disease, obesity, and even neurological disorders. Bacteria and their by-products are used for various industrial and clinical purposes. The metabolites under discussion were chosen based on their biological impacts on host and gut microbiota interactions as established by metabolome research. The separation of bacterial metabolites by using statistics and machine learning analysis creates new opportunities for applications of bacteria and their metabolites in the environmental and medical sciences. Thus, the metabolite production strategies, methodologies, and importance of bacterial metabolites for human well-being are discussed in this review.
{"title":"Bacterial metabolomics: current applications for human welfare and future aspects","authors":"Qazi Mohammad Sajid Jamal , Varish Ahmad","doi":"10.1080/10286020.2024.2385365","DOIUrl":"10.1080/10286020.2024.2385365","url":null,"abstract":"<div><div>An imbalanced microbiome is linked to several diseases, such as cancer, inflammatory bowel disease, obesity, and even neurological disorders. Bacteria and their by-products are used for various industrial and clinical purposes. The metabolites under discussion were chosen based on their biological impacts on host and gut microbiota interactions as established by metabolome research. The separation of bacterial metabolites by using statistics and machine learning analysis creates new opportunities for applications of bacteria and their metabolites in the environmental and medical sciences. Thus, the metabolite production strategies, methodologies, and importance of bacterial metabolites for human well-being are discussed in this review.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 207-230"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Four new homoisoflavonoids, 7-hydroxy-3-[hydroxy(4′-methoxyphenyl)methyl]-benzopyran-4-one (1), (3R)-7, 8-dihydroxy-3-(4′-methoxybenzyl)-chroman-4-one (2), 7-hydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (3), and 7-hydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-benzopyran-4-one (4), were isolated from the seeds of Caesalpinia pulcherrima. The structures of new compounds were elucidated by MS and NMR spectra. Their absolute configurations were assigned using electronic circular dichroism spectrum. Compounds 2 and 4 exhibited cytotoxic effects on MCF-7/TAM cells with the IC50 values of 101.4 ± 0.03 and 93.02 ± 0.03 μM, respectively.
{"title":"Four new homoisoflavonoids from Caesalpinia pulcherrima","authors":"Yu-Cheng Zheng , Wen-Jian Gu , Ren-Geng Shu , Pu-Zhao Zhang","doi":"10.1080/10286020.2024.2387307","DOIUrl":"10.1080/10286020.2024.2387307","url":null,"abstract":"<div><div>Four new homoisoflavonoids, 7-hydroxy-3-[hydroxy(4′-methoxyphenyl)methyl]-benzopyran-4-one (<strong>1</strong>), (3<em>R</em>)<strong><em>-</em></strong>7, 8-dihydroxy-3-(4′-methoxybenzyl)-chroman-4-one (<strong>2</strong>), 7-hydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (<strong>3</strong>), and 7-hydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-benzopyran-4-one (<strong>4</strong>), were isolated from the seeds of <em>Caesalpinia pulcherrima</em>. The structures of new compounds were elucidated by MS and NMR spectra. Their absolute configurations were assigned using electronic circular dichroism spectrum. Compounds <strong>2</strong> and <strong>4</strong> exhibited cytotoxic effects on MCF-7/TAM cells with the IC<sub>50</sub> values of 101.4 ± 0.03 and 93.02 ± 0.03 <em>μ</em>M, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 2","pages":"Pages 126-135"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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