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Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways. Atramacronoid A可通过CASP-3/PARP-GSDMD-MLKL途径诱导人乳腺癌细胞的泛凋亡样细胞死亡。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI: 10.1080/10286020.2024.2368841
Jing-Rong Li, Ling-Yu Li, Hai-Xin Zhang, Ming-Qin Zhong, Zhong-Mei Zou

Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of Atractylodes macrocephala Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.

乳腺癌是最常见的恶性肿瘤,也是全球妇女死亡的主要原因。Atramacronoid A (AM-A) 是一种独特的天然倍半萜内酯,从白术根茎中分离出来。我们的研究表明,AM-A 能引发一种特殊形式的细胞死亡,类似于 PANoptosis 样细胞死亡。进一步的分析表明,AM-A诱导的PAN凋亡样细胞死亡与线粒体功能障碍介导的CASP-3/PARP-GSDMD-MLKL通路有关。这些结果表明,AM-A 有可能成为一种先导化合物,并为从天然产品中开发乳腺癌治疗药物提供了启示。
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引用次数: 0
Five new glycosides from the culms of Phyllostachys nigra var. henonis. 从黑木耳变种秆中提取的五种新苷。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1080/10286020.2024.2366450
Bao Zhang, Hai-Hua Yuan, Jia Sun, Hang Xun, Jie Wang, Feng Qiu, Jian-Jun Wang, Xi Yao, Jin Wang, Wei Fan, Feng Tang

Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-O-β-D-glucopyranoside (1), (1aS,3aS,3R)-3-(4'-O-β-D-glucopyranosyl-3'-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one (2), quinolin-4(1H)-one-3-O-β-D-glucopyranoside (3), 3-methoxy-propiophenone 4-O-(6'-β-D-xylopyranosyl)-β-D-glucopyranoside (4), methyl 3-methoxybenzoate 4-O-(6'-β-D-xylopyranosyl)-β-D-glucopyranoside (5), and one known compound, bambulignan B (6) were isolated from the culms of Phyllostachys nigra var. henonis. Their structures were determined using spectroscopic analysis. All compounds were evaluated for their DPPH radical scavenging activity. Compound 6 exhibited antioxidant activity with IC50 value of 59.5 μM (positive control, L-ascorbic acid, IC50 = 12.4 μM; 2,6-ditertbutyl-4-methyl phenol, IC50 = 11.8 μM).

五种新苷,即 3-甲氧基苯甲酸甲酯-4,5-二-O-β-D-吡喃葡萄糖苷 (1)、(1aS,3aS,3R)-3-(4'-O-β-D-吡喃葡萄糖基-3'-甲氧基苯基)-5,6-二氧杂双环[3.3.0]辛烷-1-酮(2)、喹啉-4(1H)-酮-3-O-β-D-吡喃葡萄糖苷(3)、3-甲氧基苯丙酮 4-O-(6'-β-D-吡喃木糖基)-β-D-吡喃葡萄糖苷(4)、从 Phyllostachys nigra var. henonis 的秆中分离出了 3-甲氧基苯甲酸甲酯 4-O-(6'-β-D-xylopyranosyl)-β-D-吡喃葡萄糖苷(5)和一种已知化合物--班布利酮 B(6)。秆中分离出来。通过光谱分析确定了它们的结构。对所有化合物的 DPPH 自由基清除活性进行了评估。化合物 6 具有抗氧化活性,其 IC50 值为 59.5 μM(阳性对照 L-抗坏血酸,IC50 = 12.4 μM;2,6-二叔丁基-4-甲基苯酚,IC50 = 11.8 μM)。
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引用次数: 0
Impact of radish seeds (Semen Raphani) on the absorption and transportation of ginsenosides in the Caco-2 cell model: a UPLC-ESI-MS analysis. 萝卜籽(Semen Raphani)对人参皂苷在 Caco-2 细胞模型中的吸收和运输的影响:UPLC-ESI-MS 分析。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-12-01 Epub Date: 2024-06-13 DOI: 10.1080/10286020.2024.2366008
Hui Li, Wen-Shuo Zhang, Rui Liu, Wei Wang, Li-Li Jiao, Zhi Liu, Wei Wu

This study examined the impact of Semen raphani on the absorption of ginsenosides from Panax ginseng C.A. Meyer (ginseng) using a Caco-2 cell model and Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS). Six primary ginsenosides (Rg1, Re, Rb1, Rb2, Rc, Rd) were quantified. Results showed that Semen Raphani increased the efflux rate of ginsenosides, particularly at higher concentrations, suggesting it inhibits their absorption. The research elucidates the intestinal absorption process of ginsenosides and the antagonistic mechanism of Semen Raphani against ginseng.

本研究利用 Caco-2 细胞模型和超高效液相色谱-电喷雾离子化-串联质谱法(UPLC-ESI-MS)研究了 Semen raphani 对人参中人参皂苷吸收的影响。对六种主要人参皂甙(Rg1、Re、Rb1、Rb2、Rc、Rd)进行了定量分析。结果表明,人参皂苷的外流率增加,尤其是在浓度较高的情况下,这表明它抑制了人参皂苷的吸收。该研究阐明了人参皂苷的肠道吸收过程以及半枝莲对人参的拮抗机制。
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引用次数: 0
A rare prenylated isoflavone-quinone from the roots of Flemingia philippinensis. 从菲律宾佛兰芒根中提取的一种罕见的前酰化异黄酮醌。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-11-01 DOI: 10.1080/10286020.2024.2421918
Sheng-Li Niu, Xiao-Zhuo Han, Yan-Ping Wang, Jia-Hui Hao, Fei Mo, Can-Can Cui, Ying-Yu Wang, Lu-Yao Zhang, Ya-Ting Sun

In order to make more rational use of Flemingia Philippinensis, a systematic separation from the roots of F. philippinensis was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (1), together with four known analogues (2-5). Their structures were established by extensive physical and spectroscopic data analysis. Anti-inflammatory activities of the isolated compounds were evaluated in lipopolysaccharide induced mouse mononuclear macrophage leukemia cells RAW 264.7 model. Compound 1 exhibited significant inhibitory effects on LPS-induced NO production and COX-2. Compound 1 also significantly affected the levels of inflammatory cytokines.

为了更合理地利用菲律宾佛兰芒,本研究对菲律宾佛兰芒的根部进行了系统分离。通过对化学成分的研究,分离出了一种罕见的前炔基异黄酮醌,即 Fleminquinone A(1),以及四种已知的类似物(2-5)。通过大量的物理和光谱数据分析,确定了它们的结构。在脂多糖诱导的小鼠单核巨噬细胞白血病细胞 RAW 264.7 模型中评估了分离化合物的抗炎活性。化合物 1 对 LPS 诱导的 NO 生成和 COX-2 具有明显的抑制作用。化合物 1 还能明显影响炎性细胞因子的水平。
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引用次数: 0
Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways. 紫杉叶素通过调节SIRT1/p53和PI3K/AKT信号通路改善D-半乳糖诱导的小鼠海马神经元HT-22细胞衰老。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-11-01 DOI: 10.1080/10286020.2024.2421925
Xing-Long Liu, Shuang Zu, Hao Yue, An-Ning Li, Ping-Ping Sun, Jian-Guo Li, Li Yan, Li-Na Ma, Shuai Zhang

By establishing an in vitro model of D-Gal-induced brain neuronal cell (HT-22) senescence, it was found that TAX treatment significantly increased the activities of SOD and GSH, while decreasing MDA levels in aging HT-22 cells, indicating that TAX effectively restored the total antioxidant capacity and antioxidant enzyme activity of aging HT-22 cells induced by D-Gal, and attenuated cellular oxidative stress injury. In addition, taxifolin could also protect HT-22 cells from aging by up-regulating SIRT1 while reducing the expression of Ac-p53, indicating that TAX may be an active substance that can effectively delay cell aging.

通过建立体外D-Gal诱导的脑神经细胞(HT-22)衰老模型,发现TAX处理可显著提高衰老HT-22细胞的SOD和GSH活性,同时降低MDA水平,表明TAX能有效恢复D-Gal诱导的衰老HT-22细胞的总抗氧化能力和抗氧化酶活性,减轻细胞氧化应激损伤。此外,Taxifolin还能通过上调SIRT1而降低Ac-p53的表达,从而保护HT-22细胞免于衰老,这表明TAX可能是一种能有效延缓细胞衰老的活性物质。
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引用次数: 0
Recent advances in natural products and derivatives with antiviral activity against respiratory syncytial virus (RSV). 具有抗呼吸道合胞病毒(RSV)病毒活性的天然产品和衍生物的最新进展。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-10-19 DOI: 10.1080/10286020.2024.2417211
Ameena Tur Rasool, Erguang Li, Ahsan Nazir

Respiratory syncytial virus (RSV) is a widespread viral infection that causes millions of high-risk illnesses annually. Medicinal herbs such as ginseng root, echinacea purpurea, and radix astragali have a positive effect on antiviral activity by preventing viral adhesion, syncytial development, inhibiting viral internalization, relieving respiratory inflammation, strengthening the immune system, and stimulating the release of interferons. The potential benefits of natural products in terms of lower costs, better patient outcomes, and fewer adverse effects are discussed. This review examines the current evidence on the prevention and control of RSV with natural ingredients and the challenges and opportunities in clinical practice.

呼吸道合胞病毒(RSV)是一种广泛传播的病毒感染,每年导致数百万人患上高危疾病。人参根、紫锥菊和黄芪等药草通过防止病毒粘附、合胞体发育、抑制病毒内化、缓解呼吸道炎症、增强免疫系统和刺激干扰素释放,对抗病毒活性有积极作用。文中讨论了天然产品在降低成本、改善患者疗效和减少不良反应方面的潜在益处。本综述探讨了利用天然成分预防和控制 RSV 的现有证据以及临床实践中的挑战和机遇。
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引用次数: 0
Monoterpene indole glycoalkaloids from the hook-bearing branches of Uncaria rhynchophylla. 钩藤含钩枝中的单萜吲哚甘氨酰生物碱。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-10-16 DOI: 10.1080/10286020.2024.2410460
Lu Rao, Fei Chen, Ming-Hui Gao, Jun-Jie Tan, Shi-Jin Qu, Chang-Heng Tan

Twelve monoterpene indole glycoalkaloids, comprising of three new ones, 19-epi-rhynchophylloside A (1), 7-epi-rhynchophylloside A (2), and 7-epi-anthocephalusine A (3), were isolated from the hook-bearing branches of Uncaria rhynchophylla. The structures and absolute configurations of 1-3 were elucidated by analysis of MS, NMR, ECD, and single-crystal X-ray diffraction or TDDFT-ECD calculations. Glycoalkaloids 1 and 3 showed significant immunosuppressive activity against the proliferation of B lymphocyte induced by LPS with broad selective index.

从钩吻科植物钩吻的生枝中分离出12种单萜烯吲哚糖生物碱,包括3种新的单萜烯吲哚糖生物碱,即19-epi-rhynchophylloside A (1)、7-epi-rhynchophylloside A (2)和7-epi-anthocephalusine A (3)。通过分析 MS、NMR、ECD 和单晶 X 射线衍射或 TDDFT-ECD 计算,阐明了 1-3 的结构和绝对构型。糖生物碱 1 和 3 对 LPS 诱导的 B 淋巴细胞增殖具有显著的免疫抑制活性,并具有广泛的选择性。
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引用次数: 0
Caenorhabditis elegans as in vivo model for the screening of natural plants-derived novel anti-aging compounds: a short introduction. 作为体内模型筛选天然植物提取的新型抗衰老化合物的草履虫:简短介绍。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-10-15 DOI: 10.1080/10286020.2024.2414189
Samah H O Zarroug

The global aging population highlights the need for effective anti-aging treatments. Natural products show promise, but thorough evaluation requires in vivo models due to the complexity of aging. Ethical concerns are driving a shift from traditional models like rabbits and mice to alternatives such as Caenorhabditis elegans. This microscopic nematode, with its short life cycle, genetic similarities to humans, and cost-effectiveness, is ideal for testing anti-aging compounds. We review studies using C. elegans to assess natural products, suggesting it could serve as a primary model for -evaluating the safety and efficacy of plant-derived anti-aging compounds.

全球人口老龄化凸显了对有效抗衰老疗法的需求。天然产品大有可为,但由于衰老的复杂性,彻底评估需要体内模型。出于伦理方面的考虑,人们正在从兔子和小鼠等传统模型向 elegans 线虫等替代模型转变。这种微小的线虫生命周期短,基因与人类相似,成本效益高,是测试抗衰老化合物的理想选择。我们回顾了利用秀丽隐杆线虫评估天然产品的研究,认为它可以作为评估植物抗衰老化合物安全性和有效性的主要模型。
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引用次数: 0
A regio-specific 4'-O-methyltransferase from Epimedium pseudowushanense regiospecifically catalyzing 8-prenylkeampferol to icaritin. 一种来自淫羊藿的区域特异性 4'-O-甲基转移酶,可将 8-异戊烯基莰菲醇催化为冰片苷。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-10-07 DOI: 10.1080/10286020.2024.2411710
Ke-Ping Feng, Ji-Mei Liu, Ri-Dao Chen, Qiao-Man Fei, Ke-Bo Xie, Da-Wei Chen, Jun-Gui Dai

Epimedium is widely used in traditional Chinese medicine and contains rich bioactive compounds. These compounds often have a methyl group at their 4'-OH position catalyzed by methyltransferases. Therefore, studying methyltransferases in Epimedium plants is of great significance. In this study, a flavonol methyltransferase, EpOMT4, was isolated from Epimedium pseudowushanense B.L. Guo. The recombinant enzyme regiospecifically transferred a methyl group to the 4'-OH position of 8-prenylkaempferol forming icaritin. The study demonstrates that enzymatic methylation of flavonoids in Epimedium plants holds significant potential and could provide a promising alternative method for the biosynthetic production of bioactive methylated prenylflavonoids.

淫羊藿被广泛用于传统中药,含有丰富的生物活性化合物。在甲基转移酶的催化下,这些化合物的 4'-OH 位置通常带有一个甲基。因此,研究淫羊藿植物中的甲基转移酶具有重要意义。本研究从 Epimedium pseudowushanense B.L. Guo 分离出了一种黄酮醇甲基转移酶 EpOMT4。该重组酶能将一个甲基特异性地转移到 8-异戊烯基山奈酚的 4'-OH 位置,形成冰片黄酮素。该研究表明,淫羊藿植物中黄酮类化合物的酶法甲基化具有很大的潜力,可为生物合成生产具有生物活性的甲基化前酰基黄酮类化合物提供一种很有前途的替代方法。
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引用次数: 0
Three new coumarins from Notopterygium incisum with potential anti-inflammatory activity. 具有潜在抗炎活性的 Notopterygium incisum 中的三种新香豆素。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-10-07 DOI: 10.1080/10286020.2024.2411704
Xue-Yan Huo, Meng-Dan Liu, Yu-Hui Chen, Yun-Jie Hu, Chen-Yi Yan, Da-Le Guo, Yu-Cheng Gu, Li-Jun Huang, Yun Deng

Three previously undescribed coumarins (1-3) were obtained from the roots of Notopterygium incisum. Their chemical structures were elucidated using a variety of spectroscopic techniques and chemical calculations. The inhibitory effects of these new compounds on NO production and pro-inflammatory factors (IL-1β, IL-6, and TNF-α) in LPS-stimulated RAW 264.7 cells were investigated. Further studies revealed that compound 1 suppressed the expression of COX-2 and iNOS while also reduced ROS accumulation. Western blot analysis demonstrated that compound 1 could inhibit the PI3K/AKT pathway by decreasing the levels of p-PI3K and p-AKT. Collectively, these findings suggest that compounds 1-3 exhibit promising anti-inflammatory properties.

从 Notopterygium incisum 的根部获得了三种以前未曾描述过的香豆素(1-3)。利用多种光谱技术和化学计算方法阐明了它们的化学结构。研究了这些新化合物对 LPS 刺激的 RAW 264.7 细胞中 NO 生成和促炎因子(IL-1β、IL-6 和 TNF-α)的抑制作用。进一步研究发现,化合物 1 抑制了 COX-2 和 iNOS 的表达,同时还减少了 ROS 的积累。Western 印迹分析表明,化合物 1 可通过降低 p-PI3K 和 p-AKT 的水平来抑制 PI3K/AKT 通路。总之,这些发现表明化合物 1-3 具有良好的抗炎特性。
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引用次数: 0
期刊
Journal of Asian Natural Products Research
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