Journal of Asian Natural Products Research最新文献

This study evaluated the potential of methyl jasmonate (MeJA) to modulate oxidative stress damage and hyperglycemia in rats with STZ-induced diabetes. MeJA treatment (5 and 10 mg/kg) improved the destructive effects of STZ-induced oxidative damage, as proved by the decline in ROS formation and lipid peroxidation. In addition, MeJA displayed a substantial upsurge in the level of tissue GSH and activity of CAT and SOD enzymes. Histological analysis confirmed MeJA alleviated liver damage. Given the crucial part oxidative stress plays in the etiology of diabetes, this study offers a novel viewpoint on MeJA's potential as a treatment.

This study investigates the therapeutic effects and mechanisms of the Yiqi Huoxue Recipe (YHR) on renal injury in Diabetic nephropathy (DN). Through mass spectrometry analysis, animal experiments, and network pharmacology approaches, it was found that YHR can ameliorate renal function indicators and pathological changes in DN rats, and reduce cell apoptosis. Mechanistic studies indicate that YHR alleviates hyperglycemia-induced renal inflammation and damage by inhibiting the HIF-1 signaling pathway, thereby improving DN.

Two undescribed alkaloids, mecichorine (1) and talaropyrazine D (2), along with four known compounds were isolated from an endophytic fungus Penicillium sp. HZ-5. Their structures were elucidated from the spectroscopic data. Furthermore, the isolated compounds were tested for their immunosuppressive activity, and compound 1 showed moderate immunosuppressive activity on Con A-induced T-lymphocyte proliferation in vitro, with an IC₅₀ value of 15.2 ± 0.3 µM, and the others showed no obvious activities up to 40 µM.

Two new iridoid glycosides, dasperosides A-B (1-2), together with two known analogues (3-4), were isolated from the air-dried roots of Dipsacus asper. Their structures were established from the spectroscopic data obtained and chemical evidence. Compounds 1-4 were tested for their cytotoxicity against six human tumor cell lines, hepatoprotective and anti-inflammatory activities.

To control plant pathogen infections, we synthesized naringenin derivatives bearing selenocyanate moieties and assayed their antibacterial activity against Xanthomonas axonopodis pv. citri, Xanthomonas oryzae pv. oryzae, and Xanthomonas oryzae pv. oryzicola via the microbroth dilution method. Structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. Compounds 4a and 4b featuring ether substitution at the 7-hydroxyl of naringenin showed potent activity against X. axonopodis pv. citri (EC₅₀: 0.33-0.38 μg/ml) and X. oryzae pv. Oryzicola (EC₅₀: 0.36-0.75 μg/ml), while 5b and 8c outperformed chlorothalonil against X. oryzae pv. Oryzae (EC₅₀: 1.05-1.42 μg/ml). This study provides valuable insights for developing novel plant disease control agents.

Tibetan Medicine Triphala (THL), consisting of Emblica officinalis, Terminalia bellerica, and Terminalia chebula, is a traditional Tibetan remedy for diabetes mellitus (DM). This study investigated THL's pancreatic metabolomic effects and impacts on paracrine factors (glucagon, insulin, somatostatin, pancreatic polypeptide) in diabetic rats. Rats were divided into six groups, gavaged for 8 weeks, with weekly blood glucose/body weight monitoring. THL reduced serum glucagon, somatostatin, pancreatic polypeptide, elevated insulin, restored pancreatic β-cell function, downregulated α/δ/pp cell expressions, normalized 5 key differential metabolites, and modulated four core metabolic pathways, exerting antidiabetic effects.

Two novel monoterpenoid quinoline alkaloids, tabernacatines A and B (1 and 2), and a new monoterpenoid indole alkaloid, tabernacatine C (3), along with three known alkaloids (4 - 6), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were elucidated based on UV, IR, HR-ESI-MS, NMR spectra analysis, X-ray diffraction, and ECD calculation methods. Compounds 1 - 6 were evaluated for their neuroprotective effects in glutamate-induced HT22 cells, and compounds 4-6 exhibited potent neuroprotective effects.