Journal of Clinical Periodontology最新文献_第8页

Microbiological and molecular profile of furcation defects in a population with untreated periodontitis 未经治疗的牙周炎患者毛囊缺损的微生物和分子特征。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-08-07 DOI: 10.1111/jcpe.14034

Pasquale Santamaria, Yi Jin, Mandeep Ghuman, Saeed Shoaie, David Spratt, Giuseppe Troiano, Luigi Nibali

Aim

To describe the microbiological composition of subgingival dental plaque and molecular profile of gingival crevicular fluid (GCF) of periodontal furcation-involved defects.

Materials and Methods

Fifty-seven participants with periodontitis contributed with a degree II–III furcation involvement (FI), a non-furcation (NF) periodontal defect and a periodontally healthy site (HS). Subgingival plaque was analysed by sequencing the V3–V4 region of the 16S rRNA gene, and a multiplex bead immunoassay was carried out to estimate the GCF levels of 18 GCF biomarkers. Aiming to explore inherent patterns and the intrinsic structure of data, an AI-clustering method was also applied.

Results

In total, 171 subgingival plaque and 84 GCF samples were analysed. Four microbiome clusters were identified and associated with FI, NF and HS. A reduced aerobic microbiota (p = .01) was detected in FI compared with NF; IL-6, MMP-3, MMP-8, BMP-2, SOST, EGF and TIMP-1 levels were increased in the GCF of FI compared with NF.

Conclusions

This is the first study to profile periodontal furcation defects from a microbiological and inflammatory standpoint using conventional and AI-based analyses. A reduced aerobic microbial biofilm and an increase of several inflammatory, connective tissue degradation and repair markers were detected compared with other periodontal defects.

目的：描述龈下牙菌斑的微生物组成以及牙周沟受累缺损的龈沟液（GCF）的分子特征：57名牙周炎患者分别患有Ⅱ-Ⅲ度龈沟受累（FI）、非龈沟（NF）牙周缺损和牙周健康部位（HS）。通过对 16S rRNA 基因 V3-V4 区域的测序分析了龈下牙菌斑，并采用多重微珠免疫测定法估算了 18 种 GCF 生物标志物的 GCF 水平。为了探索数据的固有模式和内在结构，还采用了人工智能聚类方法：结果：共分析了 171 份龈下牙菌斑样本和 84 份 GCF 样本。结果：共分析了 171 个龈下牙菌斑和 84 个 GCF 样本，确定了四个微生物群，并将其与 FI、NF 和 HS 相关联。与 NF 相比，FI 的需氧微生物群减少（p = .01）；与 NF 相比，FI 的 GCF 中 IL-6、MMP-3、MMP-8、BMP-2、SOST、EGF 和 TIMP-1 水平升高：这是首次使用传统和人工智能分析方法从微生物和炎症角度剖析牙周沟缺陷的研究。与其他牙周缺陷相比，该研究发现需氧微生物生物膜减少，多种炎症、结缔组织降解和修复标志物增加。

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引用次数: 0

Salivary and serum inflammatory biomarkers during periodontitis progression and after treatment 牙周炎发展过程中和治疗后的唾液和血清炎症生物标志物。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-08-05 DOI: 10.1111/jcpe.14048

Flavia R. F. Teles, Ganesh Chandrasekaran, Lynn Martin, Michele Patel, Michael J. Kallan, Camila Furquim, Tahir Hamza, Andrew J. Cucchiara, Alpdogan Kantarci, Olivia Urquhart, James Sugai, William V. Giannobile

Aim

To identify serum- and salivary-derived inflammatory biomarkers of periodontitis progression and determine their response to non-surgical treatment.

Materials and Methods

Periodontally healthy (H; n = 113) and periodontitis patients (P; n = 302) were monitored bi-monthly for 1 year without therapy. Periodontitis patients were re-examined 6 months after non-surgical periodontal therapy (NSPT). Participants were classified according to disease progression: P0 (no sites progressed; P1: 1–2 sites progressed; P2: 3 or more sites progressed). Ten salivary and five serum biomarkers were measured using Luminex. Log-transformed levels were compared over time according to baseline diagnosis, progression trajectory and after NSPT. Significant differences were sought using linear mixed models.

Results

P2 presented higher levels (p < .05) of salivary IFNγ, IL-6, VEGF, IL-1β, MMP-8, IL-10 and OPG over time. Serum analytes were not associated with progression. NSPT led to clinical improvement and significant reduction of IFNγ, IL-6, IL-8, IL-1β, MMP-8, IL-10, OPG and MMP-9 in saliva and of CRP, MMP-8, MMP-9 and MPO in serum.

Conclusions

Periodontitis progression results from a sustained pro-inflammatory milieu that is reflected in salivary biomarkers, but less so in serum, likely because of the limited amount of progression per patient. NSPT can significantly decrease the levels of several salivary analytes.

目的：确定牙周炎进展的血清和唾液源性炎症生物标志物，并确定它们对非手术治疗的反应：对牙周健康者（H；n = 113）和牙周炎患者（P；n = 302）每两个月进行一次监测，为期一年，不进行治疗。牙周炎患者在接受非手术牙周治疗（NSPT）6个月后接受复查。根据疾病进展情况对参与者进行分类：P0（无进展部位；P1：1-2 个进展部位；P2：3 个或更多进展部位）。使用 Luminex 测定了 10 种唾液生物标记物和 5 种血清生物标记物。根据基线诊断、进展轨迹和 NSPT 后的对数变换水平对不同时期进行比较。使用线性混合模型寻找显著差异：结果：P2 水平较高（P牙周炎的进展源于持续的促炎症环境，唾液中的生物标志物反映了这种环境，但血清中的反映较少，这可能是因为每位患者的进展量有限。NSPT 可以显著降低唾液中几种分析物的水平。

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引用次数: 0

Structure, governance and delivery of specialist training programs in periodontology and implant dentistry 牙周病学和种植牙专科培训计划的结构、管理和实施。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-28 DOI: 10.1111/jcpe.14033

Moshe Goldstein, Nikolaos Donos, Wim Teughels, Nikolaos Gkranias, Andy Temmerman, Jan Derks, Bahar Eren Kuru, Maria Clotilde Carra, Ana Belen Castro, Xanthippi Dereka, Christel Dekeyser, David Herrera, Katleen Vandamme, Elena Calciolari

Aim

To update the competences and learning outcomes and their evaluation, educational methods and education quality assurance for the training of contemporary specialists in periodontology, including the impact of the 2018 Classification of Periodontal and Peri-implant Diseases and Conditions (2018 Classification hereafter) and the European Federation of Periodontology (EFP) Clinical Practice Guidelines (CPGs).

Methods

Evidence was gathered through scientific databases and by searching for European policies on higher education. In addition, two surveys were designed and sent to program directors and graduates.

Results

Program directors reported that curricula were periodically adapted to incorporate advances in diagnosis, classification, treatment guidelines and clinical techniques, including the 2018 Classification and the EFP CPGs. Graduates evaluated their overall training positively, although satisfaction was limited for training in mucogingival and surgical procedures related to dental implants. Traditional educational methods, such as didactic lectures, are still commonly employed, but they are now often associated with more interactive methods such as case-based seminars and problem-based and simulation-based learning. The evaluation of competences/learning outcomes should employ multiple methods of assessment.

Conclusion

An update of competences and learning outcomes of specialist training in periodontology is proposed, including knowledge and practical application of the 2018 Classification and CPGs. Harmonizing specialist training in periodontology is a critical issue at the European level.

目的：更新当代牙周病学专家培训的能力和学习成果及其评估、教育方法和教育质量保证，包括 2018 年牙周和种植体周围疾病与条件分类（以下简称 2018 年分类）和欧洲牙周病学联合会（EFP）临床实践指南（CPGs）的影响：通过科学数据库和搜索欧洲高等教育政策收集证据。此外，还设计并向课程负责人和毕业生发送了两份调查问卷：结果：课程负责人表示，课程会定期调整，以纳入诊断、分类、治疗指南和临床技术的进展，包括2018年分类和EFP CPGs。毕业生对整体培训给予了积极评价，但对牙科种植相关的粘膜牙龈和外科手术培训的满意度有限。传统的教育方法，如说教式讲座，仍被普遍采用，但现在往往与互动性更强的方法相结合，如基于案例的研讨会、基于问题的学习和基于模拟的学习。对能力/学习成果的评估应采用多种评估方法：建议更新牙周病学专科培训的能力和学习成果，包括2018年分类和CPGs的知识和实际应用。统一牙周病学专科培训是欧洲层面的一个关键问题。

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引用次数: 0

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-24 DOI: 10.1111/jcpe.14043

L. Thiemann, M. Katzschner, G. Hanna, A. B. Kruse, K. Vach, P. Ratka-Krüger, J. P. Woelber

Aim

Oral hygiene-related self-efficacy (OHSE) describes one's confidence to successfully execute oral hygiene behaviour. The aim of this study was to investigate the long-term course of OHSE in patients during initial periodontal therapy (IPT) and supportive periodontal therapy (SPT) and its association with clinical parameters.

Materials and Methods

Patients diagnosed with periodontitis, undergoing either IPT or SPT, were evaluated at two timepoints. Clinical examination included pocket probing depths (PPDs), clinical attachment loss (CAL), bleeding on probing (BOP), plaque index (PI) and gingival index (GI). Patients' OHSE was assessed with a questionnaire. Statistical analyses included t-tests and linear regression models.

Results

Ninety-eight patients from an initial group of 201 patients were evaluated after 4 years. The overall OHSE score increased significantly in the IPT group (mean 11.65 ± 15.6, p = .001). The increase in the OHSE category ‘interdental cleaning’ was significantly correlated with a decrease in the number of pockets requiring treatment (Spearman correlation r_s = −.2349, p = .022) and periodontal inflamed surface area (PISA) (r_s = −.2099, p = .042).

Conclusions

Patients under IPT showed a significant increase of OHSE compared to those under SPT. Improved OHSE, particularly in interdental cleaning, appears to be associated with sustained success of periodontal therapy.

目的：口腔卫生相关自我效能感（OHSE）描述了一个人成功实施口腔卫生行为的信心。本研究旨在调查初始牙周治疗（IPT）和支持性牙周治疗（SPT）患者口腔卫生相关自我效能感的长期变化过程及其与临床参数的关系：在两个时间点对接受IPT或SPT治疗的牙周炎患者进行评估。临床检查包括牙周袋探诊深度（PPD）、临床附着丧失（CAL）、探诊出血（BOP）、牙菌斑指数（PI）和牙龈指数（GI）。患者的 OHSE 通过问卷进行评估。统计分析包括 t 检验和线性回归模型：对最初的 201 名患者中的 98 名患者进行了 4 年后的评估。在 IPT 组中，OHSE 总分显著增加（平均值为 11.65 ± 15.6，p = .001）。OHSE中 "牙间清洁 "类别的增加与需要治疗的牙周袋数量的减少（Spearman相关性rs = -.2349, p = .022）和牙周炎症表面积（PISA）（rs = -.2099, p = .042）显著相关：结论：与 SPT 相比，IPT 患者的 OHSE 显著增加。OHSE的改善，尤其是在牙间清洁方面，似乎与牙周治疗的持续成功有关。

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引用次数: 0

Assessment of soft and hard tissue changes following micro crestal flap—Alveolar ridge preservation and augmentation at molar extraction sites in patients with stage III/IV periodontitis: A randomized controlled trial 对 III/IV 期牙周炎患者拔牙部位的微牙冠瓣-牙槽嵴保留和隆起术后软组织和硬组织变化的评估：随机对照试验。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-23 DOI: 10.1111/jcpe.14045

Haoyun Zhang, Tao Xu, Yiping Wei, Ning Wei, Ziyao Han, Wenjie Hu

Aim

This study aimed to assess hard and soft tissue contour changes following micro crestal flap-alveolar ridge preservation (MCF-ARP) and natural healing (NH) in periodontally compromised molar extraction sites and to analyse the feasibility and need for bone augmentation during implant therapy.

Materials and Methods

Fifty-six patients with 70 sites were randomized into two groups at the site level (35 sites from 31 patients in the test group and 35 sites from 29 patients in the control group). Among whom, four patients contributed one tooth to the control group and one tooth to the test group. Hard tissue indicators were measured using cone beam computed tomography performed before tooth extraction and 6 months after surgery. Soft tissue contour changes were assessed using intraoral scanning performed before and immediately after surgery and also 2 weeks and 1, 3 and 6 months after surgery.

Results

Six months after surgery, the MCF-ARP group showed less resorption in buccal bone height (p = .032) and greater augmentation in central bone height (p = .001) and ridge width (p = .009). The mean, vertical and horizontal collapse of buccal soft tissue contour in the MCF-ARP group were 0.95 mm (p = .010), 0.61 mm (p = .019) and 0.56 mm (p = .013) less than that in the NH group, respectively. There were significantly (p = .007) fewer sites in the MCF-ARP group than in the NH group (0% vs. 26.7%) for staged bone augmentation and more sites that could be treated with simple implant procedure in the MCF-ARP group than in the NH group (71.9% vs. 56.6%).

Conclusions

Compared with NH, MCF-ARP reduced bone resorption in periodontally compromised molar extraction sites and maintained the buccal soft tissue contour. MCF-ARP reduces the need for complex bone augmentation procedures in implant therapy. Trial registration: Chinese Clinical Trial Register (ChiCTR) ChiCTR2200056335. Registered on 4 February 2022, Version 1.0.

目的：本研究旨在评估牙周受损的磨牙拔除部位在微骨嵴瓣-牙槽嵴保存术（MCF-ARP）和自然愈合（NH）后软硬组织轮廓的变化，并分析种植治疗期间骨增量的可行性和必要性：将 56 名患者的 70 个部位随机分为两组（试验组 35 个部位，来自 31 名患者；对照组 35 个部位，来自 29 名患者）。其中，4 名患者的一颗牙齿属于对照组，一颗牙齿属于测试组。在拔牙前和术后 6 个月，使用锥形束计算机断层扫描测量硬组织指标。软组织轮廓变化通过口内扫描进行评估，扫描时间为术前和术后即刻，以及术后 2 周、1、3 和 6 个月：术后 6 个月，MCF-ARP 组的颊骨高度吸收较少（p = 0.032），中心骨高度（p = 0.001）和牙脊宽度（p = 0.009）增加较多。与 NH 组相比，MCF-ARP 组颊软组织轮廓的平均、垂直和水平塌陷分别减少了 0.95 毫米（p = 0.010）、0.61 毫米（p = 0.019）和 0.56 毫米（p = 0.013）。MCF-ARP组需要分阶段骨增量的部位（0% vs. 26.7%）明显少于NH组（p = .007），而MCF-ARP组可以通过简单种植手术治疗的部位（71.9% vs. 56.6%）多于NH组：与 NH 相比，MCF-ARP 可减少牙周受损的臼齿拔除部位的骨吸收，并保持颊软组织轮廓。试验注册：试验注册：中国临床试验注册中心（ChiCTR）ChiCTR2200056335。注册日期：2022 年 2 月 4 日，版本 1.0。

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引用次数: 0

The efficacy of reconstructive therapy in the surgical management of peri-implantitis: A 3-year follow-up of a randomized clinical trial 重建疗法在种植体周围炎手术治疗中的疗效：随机临床试验的三年随访。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-17 DOI: 10.1111/jcpe.14049

Stefan Renvert, Jean-Louis Giovannoli, Sven Rinke

Aim

To assess whether guided bone regeneration (GBR) treatment of peri-implantitis-related bony defects could improve healing compared to open flap debridement (OFD) at 36 months.

Materials and Methods

In a multi-centre, randomized clinical trial, 32 individuals received OFD (control group [CG]) and 34 GBR treatment (test group [TG]). Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding on probing (BOP) suppuration (SUP), mucosal recession (MREC) and patient-reported outcomes (PROs) were evaluated at 36 months.

Results

Fifty individuals attended a supportive peri-implant therapy program and completed the 36-month follow-up. GBR treatment resulted in an RDF of 2.13 ± 1.26 mm compared to 1.64 ± 1.54 mm following OFD (p = .18). No difference was found in PPD, BOP, SUP, REC or PROs between the groups. Successful treatment (no additional bone loss, PPD ≤ 5 mm, no BOP and no SUP) was achieved in 46.2% in TG and 20% in CG (p = .053). Treatment results obtained at 12 months were generally maintained up to 36 months. No significant changes were noticed between 12 and 36 months.

Conclusions

At 36 months, treatment results obtained at 1 year were sustained following both GBR and OFD in patients attending supportive peri-implant therapy. GBR resulted in more RDF and higher composite treatment success rate than OFD (ClinicalTrials.gov Identifier [NCT02375750]).

目的：与开放皮瓣清创术（OFD）相比，评估种植体周围炎相关骨缺损的引导骨再生（GBR）治疗是否能在36个月后改善愈合情况：在一项多中心随机临床试验中，32 人接受了开放皮瓣清创术（对照组 [CG]），34 人接受了 GBR 治疗（试验组 [TG]）。在 36 个月时对放射学缺损填充（RDF）、探诊袋深度（PPD）、探诊出血（BOP）、化脓（SUP）、粘膜衰退（MREC）和患者报告结果（PROs）进行评估：结果：50 人参加了支持性种植体周围治疗项目，并完成了 36 个月的随访。GBR 治疗后的 RDF 为 2.13 ± 1.26 mm，而 OFD 治疗后的 RDF 为 1.64 ± 1.54 mm（p = .18）。两组之间在 PPD、BOP、SUP、REC 或 PRO 方面没有差异。治疗成功率（无额外骨质流失、PPD ≤ 5 毫米、无 BOP 和无 SUP）：TG 组为 46.2%，CG 组为 20%（p = .053）。12 个月时取得的治疗效果一般都能保持到 36 个月。结论：36个月后，接受GBR和OFD支持性种植体周围治疗的患者在1年后获得的治疗效果得以保持。与 OFD 相比，GBR 的 RDF 更多，综合治疗成功率更高（ClinicalTrials.gov Identifier [NCT02375750]）。

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引用次数: 0

Correction to “Selective BET inhibitor RVX-208 ameliorates periodontal inflammation and bone loss” 更正为 "选择性 BET 抑制剂 RVX-208 可改善牙周炎症和骨质流失"。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-17 DOI: 10.1111/jcpe.14044

Sun, M, Clayton, N, Alam, S, Asmussen, N, Wong, A, Kim, JH, Luong, G, Mokhtari, S, Pellei, D, Carrico, CK, Schwartz, Z, Boyan, BD, Giannobile, WV, Sahingur, SE, Lin, Z. J Clin Periodontol. 2023 Dec; 50(12): 1658–1669. https://doi.org/10.1111/jcpe.13887. Epub 2023 Oct 19.

In materials and methods 2.1 (page 1660), the following sentence should have been as follows:

“THP-1 cells were cultured in Roswell Park Memorial Institute (RPMI) 1640 medium (Life Technologies) with 10% HI-FBS, 0.05 mM 2-mercaptoethanol and 1% PS.”

In materials and methods 2.2 (page 1660), the following sentence should have been as follows:

“For THP-1 cells, the cells were pre-treated using 50 ng/mL PMA overnight to initiate the cell attachment and differentiation.”

The experimental results and corresponding conclusions mentioned in the paper remain unaffected. We sincerely apologize for this error.

Sun, M, Clayton, N, Alam, S, Asmussen, N, Wong, A, Kim, JH, Luong, G, Mokhtari, S, Pellei, D, Carrico, CK, Schwartz, Z, Boyan, BD, Giannobile, WV, Sahingur, SE, Lin, Z. J Clin Periodontol. 2023 年 12 月；50（12）：1658–1669. https://doi.org/10.1111/jcpe.13887.Epub 2023 Oct 19.在材料与方法 2.1（第 1660 页）中，以下句子应为："THP-1 细胞在罗斯威尔公园纪念研究所（RPMI）1640 培养基（Life Technologies）中培养，培养基中添加 10% HI-FBS、0.05 mM 2-巯基乙醇和 1% PS。2（第 1660 页）中，以下句子应为："对于 THP-1 细胞，使用 50 ng/mL PMA 预处理细胞一夜，以启动细胞附着和分化。"论文中提到的实验结果和相应结论不受影响。我们对这一错误表示诚挚的歉意。

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引用次数: 0

Mendelian randomization studies of periodontitis: Understanding benefits and natural limitations in an applied context 牙周炎的孟德尔随机研究：了解应用背景下的优势和自然限制。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-16 DOI: 10.1111/jcpe.14029

Simon Haworth, Nicholas J. Timpson, Kimon Divaris

Mendelian randomization (MR) is a flexible analytical tool that has been widely applied to strengthen causal inference in observational epidemiology and is now gaining attention in many areas including periodontal research. The interpretation of results drawn from MR is based on a series of assumptions, which can be unrealistic or difficult to meet faithfully in some settings. However, we argue that with care, this does not necessarily prevent valuable deployment of the approach. We argue that clarity of presentation as well as careful assessment of specific analytical conditions is a fundamental part of all MR analyses. To that end, awareness of its limitations should also guide the design of MR investigations and the presentation of results rather than rule out its use altogether. Notably, considerations similar to those known to be important in conventional epidemiological settings apply to MR. While MR studies are valuable in their contrast to other study limitations, the application of this technique must be carefully cross-examined. Specific considerations include possible confounders, recruitment strategy and phenotypic measurement and differential analysis properties across studies. In the case of periodontal research, current MR applications are limited by the available evidence base for genetic contributions to periodontitis; however, this sets a specific scene for the strategic use of MR and shines light on a need for greater research emphasis on the genetics of the condition and intermediaries. This article provides a perspective on the uses and inherent limitations of MR studies and the importance of adhering to basic epidemiological principles when designing them.

孟德尔随机化（Mendelian randomization，MR）是一种灵活的分析工具，已被广泛应用于加强观察性流行病学的因果推断，目前在包括牙周病研究在内的许多领域正受到越来越多的关注。对遗传变异法得出的结果的解释基于一系列假设，在某些情况下，这些假设可能不切实际或难以忠实地实现。不过，我们认为，只要小心谨慎，这并不一定会妨碍该方法的宝贵应用。我们认为，清晰的表述以及对具体分析条件的仔细评估是所有 MR 分析的基本组成部分。为此，对其局限性的认识也应指导磁共振研究的设计和结果的呈现，而不是完全排除其使用。值得注意的是，与传统流行病学环境中已知的重要因素类似的考虑因素也适用于磁共振。虽然磁共振研究在对比其他研究局限性方面很有价值，但在应用这种技术时必须仔细斟酌。具体考虑因素包括可能的混杂因素、招募策略和表型测量，以及不同研究之间的差异分析特性。就牙周研究而言，目前磁共振技术的应用受限于牙周炎遗传因素的现有证据基础；不过，这为战略性使用磁共振技术提供了一个特定场景，并揭示了对牙周炎遗传学和中间体进行更多研究的必要性。本文从一个角度阐述了磁共振研究的用途和固有局限性，以及在设计磁共振研究时遵守基本流行病学原则的重要性。

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引用次数: 0

Non-surgical retreatment versus papillary preservation flap surgery for residual pockets: A randomized controlled trial with clinical and patient-reported outcomes 治疗残余牙周袋的非手术再治疗与乳头保留瓣手术：临床和患者报告结果的随机对照试验。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-16 DOI: 10.1111/jcpe.14047

Luigi Barbato, Desirée Noce, Maria Di Martino, Walter Castelluzzo, Folco Spoleti, Cosimo Rupe, Michele Nieri, Francesco Cairo

Aim

To compare the efficacy of non-surgical re-instrumentation (NSR) and papillary preservation flap (PPF) surgery at single-rooted teeth with residual pockets.

Materials and Methods

Patients with at least a residual pocket depth (PD ≥ 5 mm) after Steps I and II were enrolled and randomly assigned to receive NSR or PPF surgery. The primary outcome was PD reduction, and secondary outcomes were clinical attachment level (CAL) change and patient-reported outcome measures (PROMs). Outcome variables were measured at baseline, 3 and 6 months. The examiner was blinded. Statistical analysis, one site for each patient, included descriptive statistics and analysis of covariance.

Results

Forty-six participants were enrolled, and one patient dropped out in the PPF group. After 6 months, both treatments resulted in significant PD reduction (1.3 ± 1.2 mm, p = .009 NSR; 2.0 ± 0.7 mm, p < .001 PPF) and CAL gain (1.0 ± 2.4 mm, p = .031 NSR; 1.4 ± 0.8 mm, p < .001 PPF). PD reduction between groups was not statistically significant (diff: 0.6 mm; 95% confidence interval [CI] [−0.3 to 1.5]; p = .167). Pocket closure was 61% NSR versus 86% PPF (p = .091). Smoking was associated with less PD reduction of almost 1 mm in both treatments. Treatment time was longer for PPF surgery, but PROMs and post-operative pain were similar between groups.

Conclusions

Both NSR and PPF reduced PD without significant difference between treatments at 6 months. PPF surgery may offer faster PD reduction, but smoking habits reduce treatment efficacy.

目的：比较对有残余袋的单根牙进行非手术再装置（NSR）和乳头保留瓣（PPF）手术的疗效：对经过步骤 I 和步骤 II 后至少有一个残余袋深度（PD ≥ 5 mm）的患者进行登记，并随机分配其接受 NSR 或 PPF 手术。主要结果是PD减少，次要结果是临床附着水平（CAL）变化和患者报告结果测量（PROMs）。结果变量在基线、3个月和6个月时进行测量。检查者为盲人。统计分析包括描述性统计和协方差分析：结果：46 名患者参加了治疗，PPF 组有一名患者退出。6 个月后，两种治疗方法都能显著减少 PD（1.3 ± 1.2 mm，p = .009 NSR；2.0 ± 0.7 mm，p 结论：NSR 和 PPF 都能减少 PD：NSR和PPF都能减少PD，但6个月后治疗效果无明显差异。PPF手术可更快地减少PD，但吸烟习惯会降低治疗效果。

{"title":"Non-surgical retreatment versus papillary preservation flap surgery for residual pockets: A randomized controlled trial with clinical and patient-reported outcomes","authors":"Luigi Barbato, Desirée Noce, Maria Di Martino, Walter Castelluzzo, Folco Spoleti, Cosimo Rupe, Michele Nieri, Francesco Cairo","doi":"10.1111/jcpe.14047","DOIUrl":"10.1111/jcpe.14047","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the efficacy of non-surgical re-instrumentation (NSR) and papillary preservation flap (PPF) surgery at single-rooted teeth with residual pockets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients with at least a residual pocket depth (PD ≥ 5 mm) after Steps I and II were enrolled and randomly assigned to receive NSR or PPF surgery. The primary outcome was PD reduction, and secondary outcomes were clinical attachment level (CAL) change and patient-reported outcome measures (PROMs). Outcome variables were measured at baseline, 3 and 6 months. The examiner was blinded. Statistical analysis, one site for each patient, included descriptive statistics and analysis of covariance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-six participants were enrolled, and one patient dropped out in the PPF group. After 6 months, both treatments resulted in significant PD reduction (1.3 ± 1.2 mm, <i>p</i> = .009 NSR; 2.0 ± 0.7 mm, <i>p</i> < .001 PPF) and CAL gain (1.0 ± 2.4 mm, <i>p</i> = .031 NSR; 1.4 ± 0.8 mm, <i>p</i> < .001 PPF). PD reduction between groups was not statistically significant (diff: 0.6 mm; 95% confidence interval [CI] [−0.3 to 1.5]; <i>p</i> = .167). Pocket closure was 61% NSR versus 86% PPF (<i>p</i> = .091). Smoking was associated with less PD reduction of almost 1 mm in both treatments. Treatment time was longer for PPF surgery, but PROMs and post-operative pain were similar between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Both NSR and PPF reduced PD without significant difference between treatments at 6 months. PPF surgery may offer faster PD reduction, but smoking habits reduce treatment efficacy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"51 10","pages":"1277-1288"},"PeriodicalIF":5.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between volatile organic compounds exposure and periodontitis: A representative cross-sectional study 挥发性有机化合物暴露与牙周炎之间的关系：一项具有代表性的横断面研究。

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology

Pub Date : 2024-07-14 DOI: 10.1111/jcpe.14041

Haitao Dong, Xueting Wang, Ning Xiao, Xin Yang, Xin Zhang, Piye Niu, Tian Chen

Aim

Periodontitis is one of the most common oral diseases and a major cause of tooth loss in adults. Environmental pollution is closely associated with the prevalence of periodontitis. However, few studies have focused on the association between volatile organic compounds (VOCs) and periodontitis. This cross-sectional study aims to examine whether exposure to VOCs is associated with periodontitis, based on data from the National Health and Nutrition Examination Survey (NHANES, 2011–2014).

Materials and Methods

We analysed data on blood VOC levels, periodontitis and related covariates from 2772 participants of the NHANES. The association between the blood VOCs and periodontitis was analysed using weighted logistic regression analysis, the restricted cubic spline (RCS) model and the weighted quantile sum (WQS) regression model. Interaction tests and mediation analysis were also conducted.

Results

After adjusting for covariates, for each natural constant-fold increase in 1,4-dichlorobenzene, the odds of having periodontitis increased by 16% (odds ratio = 1.16; 95% confidence interval: 1.08–1.24, p < .001). WQS regression model indicated that 1,4-dichlorobenzene contributed the most to the association between VOC co-exposure and periodontitis. Mediation analysis further revealed that total bilirubin levels mediated the association between 1,4-dichlorobenzene and the prevalence of periodontitis, accounting for 4.32%. In addition, the positive association between o-xylene and periodontitis was more pronounced in the <65-year-old group.

Conclusions

This study has provided relatively little evidence to demonstrate a specific link between VOCs and periodontitis. Nonetheless, exposure to VOCs remains a non-negligible public health concern, and further research is required to investigate the association and potential mechanisms of action between VOCs and periodontitis.

目的：牙周炎是最常见的口腔疾病之一，也是成年人牙齿脱落的主要原因。环境污染与牙周炎的发病率密切相关。然而，很少有研究关注挥发性有机化合物（VOC）与牙周炎之间的关系。这项横断面研究旨在根据美国国家健康与营养调查（NHANES，2011-2014 年）的数据，研究暴露于挥发性有机化合物是否与牙周炎有关：我们分析了2772名NHANES参与者的血液中挥发性有机化合物水平、牙周炎和相关协变量的数据。我们使用加权逻辑回归分析、受限立方样条（RCS）模型和加权量化和（WQS）回归模型分析了血液中挥发性有机化合物与牙周炎之间的关系。此外，还进行了交互检验和中介分析：结果：在对协变量进行调整后，1,4-二氯苯的浓度每增加一个自然常数倍，患牙周炎的几率就会增加 16%（几率比 = 1.16；95% 置信区间：1.08-1.24，P 结论：该研究为牙周炎的发生提供了相对较少的证据：本研究提供的证据相对较少，无法证明挥发性有机化合物与牙周炎之间存在特定联系。然而，暴露于挥发性有机化合物仍然是一个不可忽视的公共健康问题，需要进一步研究挥发性有机化合物与牙周炎之间的关联和潜在作用机制。

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引用次数: 0