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Bioengineering Approaches and Novel Biomaterials to Enhance Sternal Wound Healing after Cardiac Surgery: A Crosstalk between Innovation and Surgical Practice. 加强心脏手术后胸骨伤口愈合的生物工程方法和新型生物材料:创新与外科实践之间的串联。
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-31 DOI: 10.3390/jfb15090254
Chiara Ferrisi, Francesco Loreni, Antonio Nenna, Omar Giacinto, Mario Lusini, Massimo Chello

Median sternotomy and steel wires for sternal closure are the standard approach for cardiac surgery. An incomplete repair associated with chest wall motion, especially in the presence of predisposing factors, can lead to life-threatening deep sternal wound infection, also known as mediastinitis, in 2-5% of cases. Despite current antibiotic and surgical treatments, mediastinitis is associated with a 10-40% mortality rate and a significant increase in morbidity and hospital stay. High mortality and difficult treatment appear to be due to bacterial biofilm, a self-produced extracellular polymeric product that incorporates host tissue and is responsible for the failure of immune defenses and standard antimicrobial therapies. Nanostructures are an effective strategy to enhance the healing process, as they establish a favorable environment for the neosynthesis of the extracellular matrix, supporting tissue development. Synthetic polymers have been proven to exhibit suitable biodegradable and mechanical properties, and their biofunctionalization to enhance cell attachment and interaction with the extracellular matrix is being widely investigated. The use of antibiotic treatments suspended in poly-D,L-lactide and polyethylene oxide and electrospun into nanofibers, or in sponges, has been shown to inhibit bacterial biofilm production. Additionally, growth factors can be incorporated into 3D bioresorbable scaffolds with the aim of constituting a structural and biological framework to organize and expedite the healing process. Therefore, these combined approaches may change the treatment of mediastinitis in the near future.

胸骨正中切开术和胸骨钢丝闭合术是心脏手术的标准方法。与胸壁运动相关的不完全修复,尤其是在存在易感因素的情况下,在 2% 到 5% 的病例中会导致危及生命的胸骨深部伤口感染,也称为纵隔炎。尽管目前有抗生素和手术治疗方法,纵隔炎的死亡率仍高达 10-40%,发病率和住院时间也显著增加。高死亡率和治疗困难似乎是由于细菌生物膜造成的,生物膜是一种自身产生的胞外高分子产物,它结合了宿主组织,是免疫防御系统和标准抗菌疗法失效的原因。纳米结构可为细胞外基质的新合成创造有利环境,支持组织发育,因此是促进愈合过程的有效策略。合成聚合物已被证明具有合适的生物可降解性和机械性能,目前正在对其生物功能化进行广泛研究,以增强细胞附着和与细胞外基质的相互作用。将抗生素处理悬浮在聚 D,L-内酰胺和聚氧化乙烯中,然后电纺成纳米纤维或海绵,已证明可抑制细菌生物膜的产生。此外,三维生物可吸收支架中还可加入生长因子,以形成结构和生物框架,组织和加速愈合过程。因此,在不久的将来,这些综合方法可能会改变纵隔炎的治疗方法。
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引用次数: 0
Assessing Microstructural, Biomechanical, and Biocompatible Properties of TiNb Alloys for Potential Use as Load-Bearing Implants. 评估可能用作承重植入物的钛铌合金的微结构、生物力学和生物相容性。
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-31 DOI: 10.3390/jfb15090253
Eyyup Murat Karakurt, Yan Huang, Yuksel Cetin, Alper Incesu, Huseyin Demirtas, Mehmet Kaya, Yasemin Yildizhan, Merve Tosun, Gulsah Akbas

Titanium-Niobium (TiNb) alloys are commonly employed in a number of implantable devices, yet concerns exist regarding their use in implantology owing to the biomechanical mismatch between the implant and the host tissue. Therefore, to balance the mechanical performance of the load-bearing implant with bone, TiNb alloys with differing porosities were fabricated by powder metallurgy combined with spacer material. Microstructures and phase constituents were characterized with energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The mechanical properties were tested by uniaxial compression, and the corrosion performance was determined via a potentiodynamic polarization experiment. To evaluate a highly matched potential implant with the host, biocompatibilities such as cell viability and proliferation rate, fibronectin adsorption, plasmid-DNA interaction, and an SEM micrograph showing the cell morphology were examined in detail. The results showed that the alloys displayed open and closed pores with a uniform pore size and distribution, which allowed for cell adherence and other cellular activities. The alloys with low porosity displayed compressive strength between 618 MPa and 1295 MPa, while the alloys with high porosity showed significantly lower strength, ranging from 48 MPa to 331 MPa. The biological evaluation of the alloys demonstrated good cell attachment and proliferation rates.

钛铌合金(TiNb)通常被用于许多植入设备中,但由于植入物与宿主组织之间的生物力学不匹配,人们对其在植入学中的应用存在担忧。因此,为了平衡承重植入体与骨骼之间的机械性能,我们采用粉末冶金法结合间隔材料制造了具有不同孔隙率的钛铌合金。利用能量色散光谱(EDS)、扫描电子显微镜(SEM)和 X 射线衍射(XRD)对微观结构和相组成进行了表征。通过单轴压缩测试了其机械性能,并通过电位极化实验确定了其腐蚀性能。为了评估与宿主高度匹配的潜在植入物,详细研究了生物相容性,如细胞活力和增殖率、纤维连接蛋白吸附、质粒与 DNA 的相互作用,以及显示细胞形态的 SEM 显微照片。结果表明,合金显示出孔隙大小和分布均匀的开放式和封闭式孔隙,有利于细胞粘附和其他细胞活动。低孔隙率合金的抗压强度介于 618 兆帕和 1295 兆帕之间,而高孔隙率合金的抗压强度明显较低,介于 48 兆帕和 331 兆帕之间。对合金进行的生物学评估表明,其细胞附着和增殖率良好。
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引用次数: 0
The Impact of the Methacrylation Process on the Usefulness of Chitosan as a Biomaterial Component for 3D Printing. 甲基丙烯酸化过程对壳聚糖作为三维打印生物材料成分的实用性的影响》(The Impact of the Methacrylation Process on the Usefulness of Chitosan as a Biaterial Component for 3D Printing)。
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-30 DOI: 10.3390/jfb15090251
Marta Klak, Katarzyna Kosowska, Milena Czajka, Magdalena Dec, Sylwester Domański, Agnieszka Zakrzewska, Paulina Korycka, Kamila Jankowska, Agnieszka Romanik-Chruścielewska, Michał Wszoła

Chitosan is a very promising material for tissue model printing. It is also known that the introduction of chemical modifications to the structure of the material in the form of methacrylate groups makes it very attractive for application in the bioprinting of tissue models. The aim of this work is to study the characteristics of biomaterials containing chitosan (BCH) and its methacrylated equivalent (BCM) in order to identify differences in their usefulness in 3D bioprinting technology. It has been shown that the BCM material containing methacrylic chitosan is three times more viscous than its non-methacrylated BCH counterpart. Additionally, the BCM material is characterized by stability in a larger range of stresses, as well as better printability, resolution, and fiber stability. The BCM material has higher mechanical parameters, both mechanical strength and Young's modulus, than the BCH material. Both materials are ideal for bioprinting, but BCM has unique rheological properties and significant mechanical resistance. In addition, biological tests have shown that the addition of chitosan to biomaterials increases cell proliferation, particularly in 3D-printed models. Moreover, modification in the form of methacrylation encourages reduced toxicity of the biomaterial in 3D constructs. Our investigation demonstrates the suitability of a chitosan-enhanced biomaterial, specifically methacrylate-treated, for application in tissue engineering, and particularly for tissues requiring resistance to high stress, i.e., vascular or cartilage models.

壳聚糖是一种非常有前景的组织模型打印材料。众所周知,以甲基丙烯酸酯基团的形式对材料结构进行化学修饰使其在组织模型生物打印中的应用极具吸引力。这项工作的目的是研究含壳聚糖(BCH)及其甲基丙烯酸酯等同物(BCM)的生物材料的特性,以确定它们在三维生物打印技术中的用途差异。研究表明,含有甲基丙烯酸壳聚糖的 BCM 材料的粘度是未甲基丙烯酸化 BCH 材料的三倍。此外,BCM 材料还具有在更大应力范围内的稳定性,以及更好的可打印性、分辨率和纤维稳定性。与 BCH 材料相比,BCM 材料具有更高的机械参数,包括机械强度和杨氏模量。两种材料都非常适合生物打印,但 BCM 具有独特的流变特性和显著的机械阻力。此外,生物测试表明,在生物材料中添加壳聚糖可增加细胞增殖,尤其是在三维打印模型中。此外,以甲基丙烯酸化的形式进行改性可降低三维结构中生物材料的毒性。我们的研究表明,壳聚糖增强型生物材料(特别是经过甲基丙烯酸酯处理的生物材料)适合应用于组织工程,尤其是需要抗高应力的组织,如血管或软骨模型。
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引用次数: 0
Active Biomedical Materials and Their Applications. 活性生物医学材料及其应用。
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-30 DOI: 10.3390/jfb15090250
Christie Ying Kei Lung

Active biomedical materials are designed to heal and restore the functions of people recovering after injuries or diseases [...].

活性生物医学材料旨在治疗和恢复伤病康复者的功能[......]。
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引用次数: 0
Dihydromyricetin Nanoparticles Alleviate Lipopolysaccharide-Induced Acute Kidney Injury by Decreasing Inflammation and Cell Apoptosis via the TLR4/NF-κB Pathway. 二氢杨梅素纳米粒子通过TLR4/NF-κB途径减少炎症和细胞凋亡,从而缓解脂多糖诱发的急性肾损伤
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-29 DOI: 10.3390/jfb15090249
Hongmei Yin, Qiaohua Yan, Yinglun Li, Huaqiao Tang

Acute kidney injury (AKI) is the most severe and fatal complication of sepsis resulting from infectious trauma. Currently, effective treatment options are still lacking. Dihydromyricetin is the main component extracted from Vine tea (Ampelopsis megalophylla Diels et Gilg). In our previous research, chitosan-tripolyphosphate-encapsulated nanoparticles of dihydromyricetin (CS-DMY-NPs) have been proven to have potential protective effects against cisplatin-induced AKI. Here, we investigated the protective effects and mechanisms of DMY and its nano-formulations against LPS-induced AKI by assessing pathological and inflammatory changes in mice. In mice with LPS-AKI treated with 300 mg/kg CS-DMY-NPs, the levels of creatinine (Cr), blood urea nitrogen (BUN), and KIM-1 were significantly reduced by 56%, 49%, and 88%, respectively. CS-DMY-NPs can upregulate the levels of GSH, SOD, and CAT by 47%, 7%, and 14%, respectively, to inhibit LPS-induced oxidative stress. Moreover, CS-DMY-NPs decreased the levels of IL-6, IL-1β, and MCP-1 by 31%, 49%, and 35%, respectively, to alleviate the inflammatory response. TUNEL and immunohistochemistry showed that CS-DMY-NPs reduced the number of apoptotic cells, increased the Bcl-2/Bax ratio by 30%, and attenuated renal cell apoptosis. Western blot analysis of renal tissue indicated that CS-DMY-NPs inhibited TLR4 expression and downregulated the phosphorylation of NF-κB p65 and IκBα. In summary, DMY prevented LPS-induced AKI by increasing antioxidant capacity, reducing inflammatory responses, and blocking apoptosis, and DMY nanoparticles were shown to have a better protective effect for future applications.

急性肾损伤(AKI)是感染性创伤导致的败血症最严重、最致命的并发症。目前,仍缺乏有效的治疗方案。二氢杨梅素是从藤茶(Ampelopsis megalophylla Diels et Gilg)中提取的主要成分。在我们之前的研究中,壳聚糖-三聚磷酸钠包裹的二氢杨梅素纳米颗粒(CS-DMY-NPs)已被证实对顺铂诱导的 AKI 具有潜在的保护作用。在这里,我们通过评估小鼠的病理和炎症变化,研究了 DMY 及其纳米制剂对 LPS 诱导的 AKI 的保护作用和机制。用 300 毫克/千克 CS-DMY-NPs 治疗 LPS-AKI 小鼠,肌酐(Cr)、血尿素氮(BUN)和 KIM-1 的水平分别显著降低了 56%、49% 和 88%。CS-DMY-NPs 能使 GSH、SOD 和 CAT 的水平分别提高 47%、7% 和 14%,从而抑制 LPS 诱导的氧化应激。此外,CS-DMY-NPs 还能使 IL-6、IL-1β 和 MCP-1 的水平分别降低 31%、49% 和 35%,从而缓解炎症反应。TUNEL 和免疫组化显示,CS-DMY-NPs 减少了凋亡细胞的数量,使 Bcl-2/Bax 比率增加了 30%,并减轻了肾细胞的凋亡。肾组织的 Western 印迹分析表明,CS-DMY-NPs 可抑制 TLR4 的表达,并下调 NF-κB p65 和 IκBα 的磷酸化。总之,DMY通过增加抗氧化能力、减少炎症反应和阻断细胞凋亡来预防LPS诱导的AKI,DMY纳米颗粒具有更好的保护效果,可用于未来的应用。
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引用次数: 0
Comparison of Biomechanical and Microstructural Properties of Aortic Graft Materials in Aortic Repair Surgeries. 主动脉修复手术中主动脉移植材料的生物力学和微结构特性比较
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-28 DOI: 10.3390/jfb15090248
Haoliang Sun, Zirui Cheng, Xiaoya Guo, Hongcheng Gu, Dalin Tang, Liang Wang

Mechanical mismatch between native aortas and aortic grafts can induce graft failure. This study aims to compare the mechanical and microstructural properties of different graft materials used in aortic repair surgeries with those of normal and dissected human ascending aortas. Five types of materials including normal aorta (n = 10), dissected aorta (n = 6), human pericardium (n = 8), bovine pericardium (n = 8) and Dacron graft (n = 5) were collected to perform uniaxial tensile testing to determine their material stiffness, and ultimate strength/stretch. The elastin and collagen contents in four tissue groups except for Dacron were quantified by histological examinations, while the material ultrastructure of five material groups was visualized by scanning electron microscope. Statistical results showed that three graft materials including Dacron, human pericardium and bovine pericardium had significantly higher ultimate strength and stiffness than both normal and dissected aortas. Human and bovine pericardia had significantly lower ultimate stretch than native aortas. Histological examinations revealed that normal and diseased aortic tissues had a significantly higher content of elastic fiber than two pericardial tissues, but less collagen fiber content. All four tissue groups exhibited lamellar fiber ultrastructure, with aortic tissues possessing thinner lamella. Dacron was composed of densely coalesced polyethylene terephthalate fibers in thick bundles. Aortic graft materials with denser fiber ultrastructure and/or higher content of collagen fiber than native aortic tissues, exhibited higher ultimate strength and stiffness. This information provides a basis to understand the mechanical failure of aortic grafts, and inspire the design of biomimetic aortic grafts.

原生主动脉和主动脉移植物之间的机械不匹配会导致移植物失效。本研究旨在比较主动脉修复手术中使用的不同移植物材料与正常和剥离的人体升主动脉的机械和微观结构特性。研究收集了五种材料,包括正常主动脉(n = 10)、解剖主动脉(n = 6)、人心包(n = 8)、牛心包(n = 8)和达克隆移植物(n = 5),进行单轴拉伸测试,以确定其材料刚度和极限强度/拉伸。除 Dacron 外,其他四组组织的弹性蛋白和胶原蛋白含量均通过组织学检查进行量化,而五组材料的材料超微结构则通过扫描电子显微镜进行观察。统计结果表明,达克隆、人心包和牛心包等三种移植物材料的极限强度和刚度明显高于正常和剥离的主动脉。人心包和牛心包的极限拉伸度明显低于原生主动脉。组织学检查显示,正常和病变主动脉组织的弹性纤维含量明显高于两种心包组织,但胶原纤维含量较少。所有四组组织都表现出层状纤维超微结构,主动脉组织的层状纤维较薄。Dacron 由密集凝聚的聚对苯二甲酸乙二醇酯纤维组成,纤维束较粗。与原生主动脉组织相比,纤维超微结构更致密和/或胶原纤维含量更高的主动脉移植材料具有更高的极限强度和刚度。这些信息为了解主动脉移植物的机械故障提供了基础,并为设计仿生物主动脉移植物提供了灵感。
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引用次数: 0
Investigating the Mechanisms of Discoloration in Modern Dental Materials: A Comprehensive Characterization Approach. 研究现代牙科材料的变色机制:综合表征法
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-27 DOI: 10.3390/jfb15090246
Maria Gawriołek, Naisargi Varma, Amadeusz Hernik, Wojciech Eliasz, Marta Strykowska, Elżbieta Paszyńska, Beata Czarnecka, Marek Sikorski

In general, patients' opinions on reaching ideal esthetics while restoring dental tissues is one of the most important part of the oral treatment. Unfortunately, discoloration of dental materials may occur due to intrinsic and extrinsic factors. The aim of the study was to evaluate the color stability of frequently used dental resin materials and determine the mechanism of their discoloration. The study used various characterization techniques (optical microscopy, Fourier-transform infrared spectroscopy, low-temperature N2 adsorption, diffuse reflectance spectroscopy, and luminescence) to understand the effect of surface defects on discoloration. The adsorption of model liquids on the surface was confirmed to be related to the increase in BET surface area. The study found that the adsorption of discolorants, such as coffee, tea, and wine, on the surface of the dental material follows the multilayer BET model. When the surface is smooth, the discoloration is usually within acceptable limits, with a maximum of ∆E = 3.3. The discoloration made by tea and demineralized water was within acceptable limits even after 7 days of exposure.

一般来说,在修复牙体组织的同时达到理想的美观效果,患者的意见是口腔治疗中最重要的部分之一。不幸的是,由于内在和外在因素,牙科材料可能会变色。本研究旨在评估常用牙科树脂材料的颜色稳定性,并确定其变色的机理。研究采用了多种表征技术(光学显微镜、傅立叶变换红外光谱、低温 N2 吸附、漫反射光谱和发光)来了解表面缺陷对变色的影响。研究证实,模型液体在表面的吸附与 BET 表面积的增加有关。研究发现,咖啡、茶和酒等变色剂在牙科材料表面的吸附遵循多层 BET 模型。当表面光滑时,变色通常在可接受的范围内,最大值为 ∆E = 3.3。茶水和去矿物质水造成的变色即使在暴露 7 天后也在可接受的范围内。
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引用次数: 0
The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review. 姜黄素纳米粒子涂层钛表面在骨生成中的功效:系统综述
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-27 DOI: 10.3390/jfb15090247
Nandita Suresh, Matti Mauramo, Tuomas Waltimo, Timo Sorsa, Sukumaran Anil

(1) Background: This systematic review critically appraises and synthesizes evidence from in vitro studies investigating the effects of curcumin nanoparticles on titanium surface modification, focusing on cell adhesion, proliferation, osteogenic differentiation, and mineralization. (2) Methods: A comprehensive electronic search was conducted in PubMed, Cochrane Central Register of Controlled Trials, and Google Scholar databases, yielding six in vitro studies that met the inclusion criteria. The search strategy and study selection process followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A qualitative methodological assessment was performed using the SciRAP (Science in Risk Assessment and Policy) method, which evaluated the reporting and methodological quality of the included studies. (3) Results: All six studies consistently demonstrated that curcumin-coated titanium surfaces inhibited osteoclastogenesis and promoted osteogenic activity, evidenced by enhanced cell adhesion, proliferation, osteogenic differentiation, and mineralization. The mean reporting quality score was 91.8 (SD = 5.7), and the mean methodological quality score was 85.8 (SD = 10.50), as assessed by the SciRAP method. Half of the studies used hydroxyapatite-coated titanium as a control, while the other half used uncoated titanium, introducing potential variability in baseline comparisons. (4) Conclusions: This systematic review provides compelling in vitro evidence supporting the osteogenic potential of curcumin nanoparticle-coated titanium surfaces. The findings suggest that this surface modification strategy may enhance titanium implants' biocompatibility and osteogenic properties, potentially improving dental and orthopedic implant outcomes. However, the review highlights significant heterogeneity in experimental designs and a concentration of studies from a single research group. Further research, particularly in vivo studies and clinical trials from diverse research teams, is essential to validate these findings and comprehensively understand the translational potential of this promising surface modification approach.

(1) 背景:本系统综述对姜黄素纳米颗粒对钛表面修饰作用的体外研究证据进行了批判性评估和综合,重点关注细胞粘附、增殖、成骨分化和矿化。(2)方法:在 PubMed、Cochrane Central Register of Controlled Trials 和 Google Scholar 数据库中进行了全面的电子检索,结果有六项体外研究符合纳入标准。搜索策略和研究筛选过程遵循了 PRISMA(系统综述和元分析首选报告项目)指南。采用 SciRAP(风险评估与政策中的科学)方法进行了定性方法评估,对纳入研究的报告和方法质量进行了评价。(3)结果:所有六项研究一致表明,姜黄素涂层钛表面可抑制破骨细胞生成,促进成骨活性,表现为细胞粘附、增殖、成骨分化和矿化增强。经SciRAP方法评估,报告质量平均得分为91.8分(SD = 5.7),方法学质量平均得分为85.8分(SD = 10.50)。半数研究使用羟基磷灰石涂层钛作为对照,而另一半研究使用未涂层钛,因此基线比较中可能存在变异。(4) 结论:本系统综述提供了令人信服的体外证据,支持姜黄素纳米粒子涂层钛表面的成骨潜力。研究结果表明,这种表面修饰策略可增强钛植入物的生物相容性和成骨特性,从而改善牙科和整形外科植入物的效果。然而,综述强调了实验设计的显著异质性,以及研究集中于一个研究小组。进一步的研究,尤其是来自不同研究团队的体内研究和临床试验,对于验证这些发现和全面了解这种前景广阔的表面改性方法的转化潜力至关重要。
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引用次数: 0
Effect of Photoaging on the Structure, Optical Properties and Roughness of One-Shade Composite Restoratives. 光老化对单色复合树脂修复体的结构、光学特性和粗糙度的影响
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-26 DOI: 10.3390/jfb15090245
Aikaterini Petropoulou, Maria Dimitriadi, Spiros Zinelis, Maria Antoniadou, George Eliades

The aim of the study was to evaluate changes in the degree of C=C conversion (DC%), chemical structure, optical properties and roughness of one-shade composites before/after photoaging. Τhe one-shade materials tested were Charisma Topaz One (CHT), Clearfil Majesty ES-2 Universal (MES), Essentia Universal (ESU) and Omnichroma (OMN), with G-aenial Anterior (CNA) serving as control. Specimens (2 mm thickness) were prepared and tested for DC% and chemical structure (ATR-FTIR spectroscopy), optical properties (L*a*b*-ΔΕ, translucency parameter-TP, opalescence parameter-OP, contrast ratio-CR and total transmittance-TT by UV-Vis spectroscopy) and roughness (Sa, Sz, Sdr, Sds and Sc by optical profilometry) before and after photoaging (Xe-arc weatherometer). Significant differences were found in DC% between top-bottom surfaces (ESU, OMN before; ESU, CNA after). Photoaging improved DC%, reduced ester peaks implying photodegradation, reduced L* (CHT, OMN, CNA), a* (CHT, CNA), b* (OMN, CNA), TP (all, except for MES), OP (only MES), CR (only MES, but an increase in CNA) and TT (CHT, OMN). OMN, CNA and MES demonstrated ΔΕ > 3.3. Photoaging significantly increased all roughness parameters in all materials, except for MES (Sz, Sdr, Sc) and OMN (Sdr). Although listed in the same group, significant differences were found in one-shade composites before and after photoaging. Several products were strongly affected by photoaging, demonstrating evidence of photodegradation, an increased roughness and color changes exceeding the clinically acceptable levels.

这项研究的目的是评估光老化前后一色复合材料的 C=C 转换程度(DC%)、化学结构、光学特性和粗糙度的变化。测试的单色材料包括 Charisma Topaz One (CHT)、Clearfil Majesty ES-2 Universal (MES)、Essentia Universal (ESU) 和 Omnichroma (OMN),对照组为 G-aenial Anterior (CNA)。制备了试样(2 毫米厚),并在光老化之前和之后(Xe-电弧风化仪)对其 DC%、化学结构(ATR-傅立叶变换红外光谱)、光学特性(L*a*b*-ΔΕ、透光参数-TP、乳白参数-OP、对比度-CR 和总透射率-TT,紫外-可见光谱)和粗糙度(Sa、Sz、Sdr、Sds 和 Sc,光学轮廓仪)进行了测试。发现上下表面之间的直流电率存在显著差异(之前为 ESU、OMN;之后为 ESU、CNA)。光照老化提高了 DC%,减少了酯峰,这意味着光降解,降低了 L*(CHT、OMN、CNA)、a*(CHT、CNA)、b*(OMN、CNA)、TP(所有,除 MES)、OP(仅 MES)、CR(仅 MES,但 CNA 增加)和 TT(CHT、OMN)。OMN、CNA 和 MES 的 ΔΕ > 3.3。除 MES(Sz、Sdr、Sc)和 OMN(Sdr)外,光照老化明显增加了所有材料的粗糙度参数。虽然被列为同一组,但单色复合材料在光老化前后存在明显差异。一些产品受到光老化的严重影响,显示出光降解、粗糙度增加和颜色变化超过临床可接受的水平。
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引用次数: 0
Surface Analysis of Orthodontic Mini-Implants after Their Clinical Use. 正畸微型植入体临床使用后的表面分析
IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2024-08-24 DOI: 10.3390/jfb15090244
Tamara Rahela Ioana, Filip George Boeru, Iulian Antoniac, Ioana Mitruț, Ionela Elisabeta Staicu, Anne Marie Rauten, Willi Andrei Uriciuc, Horia Octavian Manolea

Temporary anchorage devices (TADs) are orthodontic mini-implants with remarkable characteristics that, once inserted, present mechanical retention (primary stability) without the process of bone osseointegration. However, interaction with the biological environment may cause changes in the morphology of the external surface of dental TADs. In this study, we used 17 TADs made of aluminum-vanadium titanium alloy, produced by two companies, which were analyzed through optical microscopy after being removed from the patients during orthodontic treatment. We evaluated the changes that appeared on the TADs' surfaces after their use in the biological environment, depending on the morphological area in which they were inserted. In our study, we found changes in the morphology of the implant surface, and especially deposits of biological material in all study groups. On all samples examined after clinical use, regardless of the period of use, corrosion surfaces in different locations were observed. Our obtained results support the idea that the biological environment is aggressive for mini-implant structures, always producing changes to their surface during their clinical use.

临时固定装置(TADs)是一种具有显著特征的正畸微型植入物,一旦植入,无需骨结合过程即可实现机械固位(主要稳定性)。然而,与生物环境的相互作用可能会导致牙科 TAD 外表面形态发生变化。在这项研究中,我们使用了由两家公司生产的 17 个铝钒钛合金 TAD,在正畸治疗期间从患者身上取下后,我们通过光学显微镜对其进行了分析。我们评估了 TAD 在生物环境中使用后其表面发生的变化,这些变化取决于插入 TAD 的形态区域。在我们的研究中,我们发现所有研究组的种植体表面形态都发生了变化,尤其是生物材料的沉积。在临床使用后检查的所有样本中,无论使用时间长短,都可以观察到不同位置的腐蚀表面。我们的研究结果支持了这样一种观点,即生物环境对微型种植体结构具有侵蚀性,在临床使用过程中总会使其表面发生变化。
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Journal of Functional Biomaterials
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