Xuping Song, Zhenjie Lian, Rui Wang, Ruixin Li, Zhenzhen Yang, Xufei Luo, Lei Feng, Zhiming Ma, Zhen Pu, Qi Wang, Long Ge, Caihong Li, Yaolong Chen, Kehu Yang, John Lavis
Background: Living evidence (LE) synthesis refers to the method of continuously updating systematic evidence reviews to incorporate new evidence. It has emerged to address the limitations of the traditional systematic review process, particularly the absence of or delays in publication updates. The emergence of COVID-19 accelerated the progress in the field of LE synthesis, and currently, the applications of artificial intelligence (AI) in LE synthesis are expanding rapidly. However, in which phases of LE synthesis should AI be used remains an unanswered question.
Objective: This study aims to (1) document the phases of LE synthesis where AI is used and (2) investigate whether AI improves the efficiency, accuracy, or utility of LE synthesis.
Methods: We searched Web of Science, PubMed, the Cochrane Library, Epistemonikos, the Campbell Library, IEEE Xplore, medRxiv, COVID-19 Evidence Network to support Decision-making, and McMaster Health Forum. We used Covidence to facilitate the monthly screening and extraction processes to maintain the LE synthesis process. Studies that used or developed AI or semiautomated tools in the phases of LE synthesis were included.
Results: A total of 24 studies were included, including 17 on LE syntheses, with 4 involving tool development, and 7 on living meta-analyses, with 3 involving tool development. First, a total of 34 AI or semiautomated tools were involved, comprising 12 AI tools and 22 semiautomated tools. The most frequently used AI or semiautomated tools were machine learning classifiers (n=5) and the Living Interactive Evidence synthesis platform (n=3). Second, 20 AI or semiautomated tools were used for the data extraction or collection and risk of bias assessment phase, and only 1 AI tool was used for the publication update phase. Third, 3 studies demonstrated the improvement in efficiency achieved based on time, workload, and conflict rate metrics. Nine studies applied AI or semiautomated tools in LE synthesis, obtaining a mean recall rate of 96.24%, and 6 studies achieved a mean F1-score of 92.17%. Additionally, 8 studies reported precision values ranging from 0.2% to 100%.
Conclusions: AI and semiautomated tools primarily facilitate data extraction or collection and risk of bias assessment. The use of AI or semiautomated tools in LE synthesis improves efficiency, leading to high accuracy, recall, and F1-scores, while precision varies across tools.
背景:活证据综合是指不断更新系统证据综述以纳入新证据的方法。它的出现是为了解决传统系统审查过程的局限性,特别是出版物更新的缺乏或延迟。COVID-19的出现加速了LE合成领域的进展,目前人工智能(AI)在LE合成中的应用正在迅速扩大。然而,人工智能应该用于LE合成的哪个阶段仍然是一个悬而未决的问题。目的:本研究旨在(1)记录使用人工智能合成LE的阶段,(2)研究人工智能是否提高了LE合成的效率、准确性或实用性。方法:检索Web of Science、PubMed、Cochrane Library、Epistemonikos、Campbell Library、IEEE explore、medRxiv、COVID-19 Evidence Network to support Decision-making和McMaster Health Forum。我们使用covid来促进每月的筛选和提取过程,以维持LE合成过程。包括在LE合成阶段使用或开发人工智能或半自动化工具的研究。结果:共纳入24项研究,其中17项关于LE合成,4项涉及工具开发;7项关于生活荟萃分析,3项涉及工具开发。首先,总共涉及34个人工智能或半自动化工具,包括12个人工智能工具和22个半自动化工具。最常用的人工智能或半自动化工具是机器学习分类器(n=5)和活体交互证据合成平台(n=3)。其次,20个人工智能或半自动工具用于数据提取或收集和偏倚风险评估阶段,只有1个人工智能工具用于出版物更新阶段。第三,3项研究证明了基于时间、工作量和冲突率度量的效率改进。9项研究将AI或半自动工具应用于LE合成,平均召回率为96.24%,6项研究的平均f1得分为92.17%。此外,8项研究报告的精度值在0.2%到100%之间。结论:人工智能和半自动化工具主要促进数据提取或收集和偏见风险评估。在LE合成中使用人工智能或半自动工具可以提高效率,从而提高准确性、召回率和f1分数,而不同工具的精度不同。
{"title":"The Phases of Living Evidence Synthesis Using AI AI: Living Evidence Synthesis (Version 1).","authors":"Xuping Song, Zhenjie Lian, Rui Wang, Ruixin Li, Zhenzhen Yang, Xufei Luo, Lei Feng, Zhiming Ma, Zhen Pu, Qi Wang, Long Ge, Caihong Li, Yaolong Chen, Kehu Yang, John Lavis","doi":"10.2196/76130","DOIUrl":"10.2196/76130","url":null,"abstract":"<p><strong>Background: </strong>Living evidence (LE) synthesis refers to the method of continuously updating systematic evidence reviews to incorporate new evidence. It has emerged to address the limitations of the traditional systematic review process, particularly the absence of or delays in publication updates. The emergence of COVID-19 accelerated the progress in the field of LE synthesis, and currently, the applications of artificial intelligence (AI) in LE synthesis are expanding rapidly. However, in which phases of LE synthesis should AI be used remains an unanswered question.</p><p><strong>Objective: </strong>This study aims to (1) document the phases of LE synthesis where AI is used and (2) investigate whether AI improves the efficiency, accuracy, or utility of LE synthesis.</p><p><strong>Methods: </strong>We searched Web of Science, PubMed, the Cochrane Library, Epistemonikos, the Campbell Library, IEEE Xplore, medRxiv, COVID-19 Evidence Network to support Decision-making, and McMaster Health Forum. We used Covidence to facilitate the monthly screening and extraction processes to maintain the LE synthesis process. Studies that used or developed AI or semiautomated tools in the phases of LE synthesis were included.</p><p><strong>Results: </strong>A total of 24 studies were included, including 17 on LE syntheses, with 4 involving tool development, and 7 on living meta-analyses, with 3 involving tool development. First, a total of 34 AI or semiautomated tools were involved, comprising 12 AI tools and 22 semiautomated tools. The most frequently used AI or semiautomated tools were machine learning classifiers (n=5) and the Living Interactive Evidence synthesis platform (n=3). Second, 20 AI or semiautomated tools were used for the data extraction or collection and risk of bias assessment phase, and only 1 AI tool was used for the publication update phase. Third, 3 studies demonstrated the improvement in efficiency achieved based on time, workload, and conflict rate metrics. Nine studies applied AI or semiautomated tools in LE synthesis, obtaining a mean recall rate of 96.24%, and 6 studies achieved a mean F1-score of 92.17%. Additionally, 8 studies reported precision values ranging from 0.2% to 100%.</p><p><strong>Conclusions: </strong>AI and semiautomated tools primarily facilitate data extraction or collection and risk of bias assessment. The use of AI or semiautomated tools in LE synthesis improves efficiency, leading to high accuracy, recall, and F1-scores, while precision varies across tools.</p>","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":"28 ","pages":"e76130"},"PeriodicalIF":6.0,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12842881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shohei Kawachi, Mariana Hoffman, Lorena Romero, Magnus Ekström, Jerry A Krishnan, Anne E Holland
<p><strong>Background: </strong>Ambulatory oxygen therapy is prescribed for patients with chronic lung diseases who experience exertional hypoxemia. However, available devices may not adequately meet user requirements, and their performance characteristics are heterogeneous.</p><p><strong>Objective: </strong>This study aims to identify devices available for delivery of ambulatory oxygen therapy, the technologies that they use to generate oxygen, the performance characteristics of each device, and the development status.</p><p><strong>Methods: </strong>We used medical and engineering databases to identify peer-reviewed papers (eg, MEDLINE, IEEE). Gray literature was used to identify additional descriptions of ambulatory oxygen devices in military medicine, space exploration, or patents. The last search was conducted in September 2025. Documents that described a device that can deliver oxygen in an ambulatory context (defined as weighing less than 10 kg) and were written in English were included. Search results were screened for inclusion by 2 independent reviewers. Data were synthesized by descriptively mapping the performance of each product, the technology used, and the development status of emerging technologies.</p><p><strong>Results: </strong>From 9702 records identified, a total of 166 met eligibility criteria (106 scientific publications and 60 gray literature). We identified 33 portable oxygen concentrators (POCs; 29 commercially available), 10 oxygen cylinders, and 6 portable liquid oxygen (LOX) devices. The POC products showed a trade-off between portability and oxygen delivery capacity (maximum flow rate ranging from 2.0 to 6.0 L/min; device weight ranging from 1.0 to 9.1 kg). Pressure swing adsorption with zeolite was the most common oxygen generation technology in POCs on the market. The mean maximum continuous operating time of POCs was 3.8 hours. Two prototype POCs (maximum flow rate of 4-6 L/min and device weight of 8-9 kg) were developed for space exploration using modified adsorbents. LOX devices were the lightest and had the longest continuous operating time. Innovations in delivery included the downsizing of a POC by using nanozeolite as an adsorbent and pulse oximeter oxygen saturation (SpO<sub>2</sub>)-targeted automatic titration of oxygen delivery based on the user's SpO<sub>2</sub>.</p><p><strong>Conclusions: </strong>This scoping review is the first study to integrate medical, engineering, and gray literature on ambulatory oxygen devices and their development. Although prior literature has narratively explained the products and technologies, no previous research has systematically investigated them. This review showed that POCs available to consumers may not meet the needs of patients in terms of flow rate, portability, and operating time. LOX devices offered superior performance but are limited by high costs. Limitations of this review include the difficulty of comparing product performance across oxygen delivery setting
{"title":"Products, Performance, and Technological Development of Ambulatory Oxygen Therapy Devices: Scoping Review.","authors":"Shohei Kawachi, Mariana Hoffman, Lorena Romero, Magnus Ekström, Jerry A Krishnan, Anne E Holland","doi":"10.2196/81077","DOIUrl":"10.2196/81077","url":null,"abstract":"<p><strong>Background: </strong>Ambulatory oxygen therapy is prescribed for patients with chronic lung diseases who experience exertional hypoxemia. However, available devices may not adequately meet user requirements, and their performance characteristics are heterogeneous.</p><p><strong>Objective: </strong>This study aims to identify devices available for delivery of ambulatory oxygen therapy, the technologies that they use to generate oxygen, the performance characteristics of each device, and the development status.</p><p><strong>Methods: </strong>We used medical and engineering databases to identify peer-reviewed papers (eg, MEDLINE, IEEE). Gray literature was used to identify additional descriptions of ambulatory oxygen devices in military medicine, space exploration, or patents. The last search was conducted in September 2025. Documents that described a device that can deliver oxygen in an ambulatory context (defined as weighing less than 10 kg) and were written in English were included. Search results were screened for inclusion by 2 independent reviewers. Data were synthesized by descriptively mapping the performance of each product, the technology used, and the development status of emerging technologies.</p><p><strong>Results: </strong>From 9702 records identified, a total of 166 met eligibility criteria (106 scientific publications and 60 gray literature). We identified 33 portable oxygen concentrators (POCs; 29 commercially available), 10 oxygen cylinders, and 6 portable liquid oxygen (LOX) devices. The POC products showed a trade-off between portability and oxygen delivery capacity (maximum flow rate ranging from 2.0 to 6.0 L/min; device weight ranging from 1.0 to 9.1 kg). Pressure swing adsorption with zeolite was the most common oxygen generation technology in POCs on the market. The mean maximum continuous operating time of POCs was 3.8 hours. Two prototype POCs (maximum flow rate of 4-6 L/min and device weight of 8-9 kg) were developed for space exploration using modified adsorbents. LOX devices were the lightest and had the longest continuous operating time. Innovations in delivery included the downsizing of a POC by using nanozeolite as an adsorbent and pulse oximeter oxygen saturation (SpO<sub>2</sub>)-targeted automatic titration of oxygen delivery based on the user's SpO<sub>2</sub>.</p><p><strong>Conclusions: </strong>This scoping review is the first study to integrate medical, engineering, and gray literature on ambulatory oxygen devices and their development. Although prior literature has narratively explained the products and technologies, no previous research has systematically investigated them. This review showed that POCs available to consumers may not meet the needs of patients in terms of flow rate, portability, and operating time. LOX devices offered superior performance but are limited by high costs. Limitations of this review include the difficulty of comparing product performance across oxygen delivery setting","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":" ","pages":"e81077"},"PeriodicalIF":6.0,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kerry Marshall, Hargun Dhillon, A Fuchsia Howard, Heather Noga, Grace J Yang, William Zhu, Jessica Sutherland, Sarah Lett, Anna Leonova, Paul J Yong, Natasha L Orr
Unlabelled: Trauma-informed approaches can promote the creation of systems that prioritize safety and empowerment to improve patient well-being. These approaches are especially important in sexual and reproductive health care, where patients are often asked to disclose sensitive and personal information. This disclosure is particularly relevant in the context of endometriosis, a condition that affects 10% of reproductive-aged women and causes debilitating pelvic pain. Our team led a trauma-informed social media campaign to raise awareness and improve the understanding of endometriosis by sharing research findings from a photovoice study focusing on Asian women's experiences of endometriosis during the COVID-19 pandemic in Canada (EndoPhoto Study). In this paper, we describe how we adapted and applied trauma-informed approaches to the development and implementation of the social media campaign. To do this, we followed five adapted trauma-informed principles: (1) support and collaboration, (2) trustworthiness and transparency, (3) safety, (4) empowerment and voice, and (5) cultural and gender sensitivity, and four steps: (1) frame the campaign, (2) create content and manage the campaign, (3) measure campaign impact, and (4) conduct postcampaign reflections. We co-designed this campaign with patient partners having lived experience of endometriosis to facilitate support and collaboration. Additionally, we shared details about the funders of this study to increase trust and transparency, moderated comments and deidentified images to promote participant safety, chose safer platforms to enhance empowerment and voice, avoided stereotypes, and shared authentic experiences of Asian women with endometriosis to support cultural and gender sensitivity. The campaign launched on Instagram and Pinterest in March 2025 to coincide with Endometriosis Awareness Month. The social media campaign received 8,540,528 total impressions over the course of the month and had engagement rates of 6.23% and 1.4% on Instagram and Pinterest, respectively.
{"title":"Developing a Trauma-Informed Social Media Campaign to Disseminate Endometriosis-Specific Qualitative Art-Based Research Findings: Tutorial.","authors":"Kerry Marshall, Hargun Dhillon, A Fuchsia Howard, Heather Noga, Grace J Yang, William Zhu, Jessica Sutherland, Sarah Lett, Anna Leonova, Paul J Yong, Natasha L Orr","doi":"10.2196/83491","DOIUrl":"10.2196/83491","url":null,"abstract":"<p><strong>Unlabelled: </strong>Trauma-informed approaches can promote the creation of systems that prioritize safety and empowerment to improve patient well-being. These approaches are especially important in sexual and reproductive health care, where patients are often asked to disclose sensitive and personal information. This disclosure is particularly relevant in the context of endometriosis, a condition that affects 10% of reproductive-aged women and causes debilitating pelvic pain. Our team led a trauma-informed social media campaign to raise awareness and improve the understanding of endometriosis by sharing research findings from a photovoice study focusing on Asian women's experiences of endometriosis during the COVID-19 pandemic in Canada (EndoPhoto Study). In this paper, we describe how we adapted and applied trauma-informed approaches to the development and implementation of the social media campaign. To do this, we followed five adapted trauma-informed principles: (1) support and collaboration, (2) trustworthiness and transparency, (3) safety, (4) empowerment and voice, and (5) cultural and gender sensitivity, and four steps: (1) frame the campaign, (2) create content and manage the campaign, (3) measure campaign impact, and (4) conduct postcampaign reflections. We co-designed this campaign with patient partners having lived experience of endometriosis to facilitate support and collaboration. Additionally, we shared details about the funders of this study to increase trust and transparency, moderated comments and deidentified images to promote participant safety, chose safer platforms to enhance empowerment and voice, avoided stereotypes, and shared authentic experiences of Asian women with endometriosis to support cultural and gender sensitivity. The campaign launched on Instagram and Pinterest in March 2025 to coincide with Endometriosis Awareness Month. The social media campaign received 8,540,528 total impressions over the course of the month and had engagement rates of 6.23% and 1.4% on Instagram and Pinterest, respectively.</p>","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":"28 ","pages":"e83491"},"PeriodicalIF":6.0,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12841857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Frontline Worker's Take on Hybrid Care Implementation in the Hospital Setting.","authors":"Jenna Congdon","doi":"10.2196/90879","DOIUrl":"10.2196/90879","url":null,"abstract":"","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":"28 ","pages":"e90879"},"PeriodicalIF":6.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suya Li, Hui-Jun Chen, Jie Zhou, Yi-Bei Zhouchen, Rong Wang, Jinyi Guo, Sharon R Redding, Yan-Qiong Ouyang
[This corrects the article DOI: .].
[更正文章DOI: .]。
{"title":"Correction: Effectiveness of a Web-Based Medication Education Course on Pregnant Women's Medication Information Literacy and Decision Self-Efficacy: Randomized Controlled Trial.","authors":"Suya Li, Hui-Jun Chen, Jie Zhou, Yi-Bei Zhouchen, Rong Wang, Jinyi Guo, Sharon R Redding, Yan-Qiong Ouyang","doi":"10.2196/91835","DOIUrl":"10.2196/91835","url":null,"abstract":"<p><p>[This corrects the article DOI: .].</p>","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":"28 ","pages":"e91835"},"PeriodicalIF":6.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pascal Raszke, Godwin Denk Giebel, Jürgen Wasem, Michael Adamzik, Hartmuth Nowak, Lars Palmowski, Philipp Heinz, Nina Timmesfeld, Marianne Tokic, Frank Martin Brunkhorst, Nikola Blase
<p><strong>Background: </strong>Global digitalization continues to advance, extending its influence into medicine and health care systems worldwide. In recent years, substantial advancements have been made in the research and development of artificial intelligence (AI), raising questions about its potential in medicine. The integration and application of AI in intensive care medicine, particularly in sepsis treatment, presents significant potential for advancing patient outcomes and enhancing patient-relevant benefits. However, a comprehensive and systematic overview of the full spectrum of patient-relevant benefits associated with AI-based clinical decision support systems (CDSS) remains lacking.</p><p><strong>Objective: </strong>This scoping review aimed to identify and categorize evidence on patient-relevant benefits of AI-based CDSS in sepsis care.</p><p><strong>Methods: </strong>Systematic research was conducted in 4 electronic databases: MEDLINE via PubMed, Embase, the ACM Digital Library, and IEEE Xplore. In addition, a comprehensive search on the websites of relevant international organizations, along with a citation search of the included articles, was conducted. Articles were included if they (1) focused on sepsis and (2) described patient-relevant benefits of AI-based CDSS. Articles published between January 1, 2008, and March 2, 2023, were considered for inclusion. Study selection was performed independently by 2 reviewers. The manuscript was drafted in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist. The analysis of the included articles was conducted using the program MAXQDA (VERBI Software GmbH), with systemization finalized in a consensus workshop.</p><p><strong>Results: </strong>A total of 3368 records were identified across the 4 databases, of which 24 met the inclusion criteria and were included in the scoping review. The additional search on international websites and in reference lists identified 6 more relevant articles, resulting in 30 included studies. Of these, 20 were quantitative, comprising 7 prospective and 13 retrospective designs. In addition, 1 qualitative study, 1 mixed methods study, 6 review articles, and 2 articles from institutional websites were included. Patient-relevant benefits were systematized in six main categories: (1) prediction, (2) earlier treatment and prioritization of high-risk patients, (3) individualized therapy, (4) improved patient outcomes (including improved Sequential Organ Failure Assessment score, reduced length of stay, and reduced mortality), (5) general improvements in care, and (6) reduced readmission rate.</p><p><strong>Conclusions: </strong>This scoping review underscores the potential of AI-based CDSS to positively impact patient-relevant benefits, particularly in sepsis care, where they demonstrate considerable promise for improving intensive care. However, the majority of the identified s
{"title":"Patient Benefits in the Context of Sepsis-Related AI-Based Clinical Decision Support Systems: Scoping Review.","authors":"Pascal Raszke, Godwin Denk Giebel, Jürgen Wasem, Michael Adamzik, Hartmuth Nowak, Lars Palmowski, Philipp Heinz, Nina Timmesfeld, Marianne Tokic, Frank Martin Brunkhorst, Nikola Blase","doi":"10.2196/76772","DOIUrl":"10.2196/76772","url":null,"abstract":"<p><strong>Background: </strong>Global digitalization continues to advance, extending its influence into medicine and health care systems worldwide. In recent years, substantial advancements have been made in the research and development of artificial intelligence (AI), raising questions about its potential in medicine. The integration and application of AI in intensive care medicine, particularly in sepsis treatment, presents significant potential for advancing patient outcomes and enhancing patient-relevant benefits. However, a comprehensive and systematic overview of the full spectrum of patient-relevant benefits associated with AI-based clinical decision support systems (CDSS) remains lacking.</p><p><strong>Objective: </strong>This scoping review aimed to identify and categorize evidence on patient-relevant benefits of AI-based CDSS in sepsis care.</p><p><strong>Methods: </strong>Systematic research was conducted in 4 electronic databases: MEDLINE via PubMed, Embase, the ACM Digital Library, and IEEE Xplore. In addition, a comprehensive search on the websites of relevant international organizations, along with a citation search of the included articles, was conducted. Articles were included if they (1) focused on sepsis and (2) described patient-relevant benefits of AI-based CDSS. Articles published between January 1, 2008, and March 2, 2023, were considered for inclusion. Study selection was performed independently by 2 reviewers. The manuscript was drafted in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist. The analysis of the included articles was conducted using the program MAXQDA (VERBI Software GmbH), with systemization finalized in a consensus workshop.</p><p><strong>Results: </strong>A total of 3368 records were identified across the 4 databases, of which 24 met the inclusion criteria and were included in the scoping review. The additional search on international websites and in reference lists identified 6 more relevant articles, resulting in 30 included studies. Of these, 20 were quantitative, comprising 7 prospective and 13 retrospective designs. In addition, 1 qualitative study, 1 mixed methods study, 6 review articles, and 2 articles from institutional websites were included. Patient-relevant benefits were systematized in six main categories: (1) prediction, (2) earlier treatment and prioritization of high-risk patients, (3) individualized therapy, (4) improved patient outcomes (including improved Sequential Organ Failure Assessment score, reduced length of stay, and reduced mortality), (5) general improvements in care, and (6) reduced readmission rate.</p><p><strong>Conclusions: </strong>This scoping review underscores the potential of AI-based CDSS to positively impact patient-relevant benefits, particularly in sepsis care, where they demonstrate considerable promise for improving intensive care. However, the majority of the identified s","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":"28 ","pages":"e76772"},"PeriodicalIF":6.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12834200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ian René Solano-Kamaiko, Michael Dicpinigaitis, Melissa Tan, Irene Yang, Kexin Cheng, Ronica Peramsetty, Michelle Shum, Yanira Escamilla, Jennifer Bayly, Meghan Reading Turchioe, Ariel Avgar, Aditya Vashistha, Nicola Dell, Madeline R Sterling
<p><strong>Background: </strong>Home health aides and attendants (HHAs) provide in-home care to the growing population of older adults who want to age in place. Despite their vital role in patient care, HHAs are an underserved and vulnerable population of health care professionals who often experience poor health themselves. Activity tracking devices offer a promising way to improve HHAs' health-related awareness and promote health behavior change, particularly regarding physical activity and sleep quality, 2 areas in which the workforce struggles.</p><p><strong>Objective: </strong>This study aimed to understand how feasible it is for HHAs to use activity tracking devices and assess their perceptions of such devices for improving their health. Specifically, we conducted (1) a field study to assess the use, feasibility, and acceptability of these devices among HHAs and (2) a qualitative study to understand HHAs' perspectives on and reactions to activity trackers on and off the job.</p><p><strong>Methods: </strong>We partnered with the 1199 Service Employees International Union Training and Employment Fund to conduct a field study with home care agency-employed HHAs working in New York City, New York. Participants wore activity tracking devices for 4 weeks that collected data on physical activity and sleep. The HHAs were subsequently interviewed on their experiences with and attitudes toward the devices and asked to reflect on personalized visualizations of their data to prompt them to think aloud. Quantitative data were analyzed using descriptive statistics. Qualitative data were analyzed using grounded theory.</p><p><strong>Results: </strong>A total of 17 HHAs participated; their mean age was 48.7 (SD 12.2) years, 15 (88%) were women, 11 (65%) identified as Black, 5 (29%) identified as Hispanic or Latinx, and they had worked as HHAs for a mean of 11.7 (SD 7.5) years. In total, 94% (n=16) of the HHAs wore their activity trackers for the full 28-day study period. Participants took a mean of 10,230 (SD 3586) daily steps during the study period and slept for a mean of 6.27 (SD 0.58) hours per night. Overall, 4 key themes emerged: (1) activity tracking devices enhanced participants' health awareness by providing empirical data for self-reflection; (2) this increased awareness led to positive behavior changes, including setting and achieving health-related goals; (3) HHAs believed that these devices could improve not only their own health but also that of their patients through positive behavior changes; and (4) despite this optimism, participants emphasized that their ability to modify sleep and activity patterns was constrained by social and occupational determinants, with sleep improvements being particularly challenging.</p><p><strong>Conclusions: </strong>Our findings suggest that appropriately designed personal tracking interventions could offer a promising approach to supporting positive health-related changes in this historically overlooked wor
{"title":"Feasibility, Acceptability, and Perspectives Regarding the Use of Activity Tracking Wearable Devices Among Home Health Aides: Mixed Methods Study.","authors":"Ian René Solano-Kamaiko, Michael Dicpinigaitis, Melissa Tan, Irene Yang, Kexin Cheng, Ronica Peramsetty, Michelle Shum, Yanira Escamilla, Jennifer Bayly, Meghan Reading Turchioe, Ariel Avgar, Aditya Vashistha, Nicola Dell, Madeline R Sterling","doi":"10.2196/77510","DOIUrl":"10.2196/77510","url":null,"abstract":"<p><strong>Background: </strong>Home health aides and attendants (HHAs) provide in-home care to the growing population of older adults who want to age in place. Despite their vital role in patient care, HHAs are an underserved and vulnerable population of health care professionals who often experience poor health themselves. Activity tracking devices offer a promising way to improve HHAs' health-related awareness and promote health behavior change, particularly regarding physical activity and sleep quality, 2 areas in which the workforce struggles.</p><p><strong>Objective: </strong>This study aimed to understand how feasible it is for HHAs to use activity tracking devices and assess their perceptions of such devices for improving their health. Specifically, we conducted (1) a field study to assess the use, feasibility, and acceptability of these devices among HHAs and (2) a qualitative study to understand HHAs' perspectives on and reactions to activity trackers on and off the job.</p><p><strong>Methods: </strong>We partnered with the 1199 Service Employees International Union Training and Employment Fund to conduct a field study with home care agency-employed HHAs working in New York City, New York. Participants wore activity tracking devices for 4 weeks that collected data on physical activity and sleep. The HHAs were subsequently interviewed on their experiences with and attitudes toward the devices and asked to reflect on personalized visualizations of their data to prompt them to think aloud. Quantitative data were analyzed using descriptive statistics. Qualitative data were analyzed using grounded theory.</p><p><strong>Results: </strong>A total of 17 HHAs participated; their mean age was 48.7 (SD 12.2) years, 15 (88%) were women, 11 (65%) identified as Black, 5 (29%) identified as Hispanic or Latinx, and they had worked as HHAs for a mean of 11.7 (SD 7.5) years. In total, 94% (n=16) of the HHAs wore their activity trackers for the full 28-day study period. Participants took a mean of 10,230 (SD 3586) daily steps during the study period and slept for a mean of 6.27 (SD 0.58) hours per night. Overall, 4 key themes emerged: (1) activity tracking devices enhanced participants' health awareness by providing empirical data for self-reflection; (2) this increased awareness led to positive behavior changes, including setting and achieving health-related goals; (3) HHAs believed that these devices could improve not only their own health but also that of their patients through positive behavior changes; and (4) despite this optimism, participants emphasized that their ability to modify sleep and activity patterns was constrained by social and occupational determinants, with sleep improvements being particularly challenging.</p><p><strong>Conclusions: </strong>Our findings suggest that appropriately designed personal tracking interventions could offer a promising approach to supporting positive health-related changes in this historically overlooked wor","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":"28 ","pages":"e77510"},"PeriodicalIF":6.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ye-Eun Park, Minsu Ock, Jae-Ho Lee, Dae-Hyun Ko, Hak-Jae Lee, Taezoon Park, Junsang Yoo, Yura Lee
Background: Artificial intelligence (AI)-enabled clinical decision support systems (CDSSs) are increasingly embedded within electronic health record (EHR) environments; however, their introduction can disrupt existing workflows and raise patient safety concerns, particularly in high-stakes settings such as surgical transfusion. Limited qualitative evidence exists regarding how frontline professionals anticipate the clinical, organizational, and workflow implications of such systems before wider deployment.
Objective: This study aims to qualitatively examine the anticipated clinical, organizational, and workflow-level implications of implementing personalized Maximum Surgical Blood Order Schedule-Thoracic Surgery (pMSBOS-TS), an AI-enabled CDSS for personalized surgical blood ordering, before large-scale deployment.
Methods: We conducted a consensual qualitative study with 14 multidisciplinary health care professionals involved in transfusion-related tasks at a large tertiary hospital. Following 1 pilot focus group to refine the interview guide and workflow diagram, 2 semistructured focus group discussions were held with 14 participants (5 physicians, 6 nurses, and 3 blood bank staff). Transcripts were analyzed using the Systems Engineering Initiative for Patient Safety (SEIPS) 101 framework, focusing on People, Environment, Tools, and Tasks, and were supported by task- and workflow-based analyses of transfusion processes. Member checking was conducted with participants and external clinicians to enhance validity.
Results: A total of 189 semantic units and 61 core ideas were identified across 18 subdomains and 7 overarching domains. Participants anticipated that pMSBOS-TS could reduce unwarranted variation in blood ordering and planning, provided that algorithmic performance is reliable and the interface is tightly integrated into existing EHR workflows. At the same time, they expressed concerns regarding increased verification burden, system limitations in unexpected clinical scenarios, and potential communication bottlenecks between clinical units and the blood bank. Organizational culture, governance structures, and local transfusion logistics were viewed as critical determinants of whether the system would reduce or inadvertently increase workload and blood product waste.
Conclusions: This preimplementation, SEIPS-based qualitative evaluation suggests that the successful adoption of an AI-enabled transfusion CDSS depends not only on predictive performance but also on sociotechnical readiness, including user trust, workflow fit, and organizational support. These findings provide practice-based insights to inform staged implementation, training, and governance strategies aimed at safely integrating predictive transfusion CDSSs into EHR-supported surgical workflows.
{"title":"Assessing Health Care Professionals' Perceptions of a New System in Clinical Workflows: Systems Engineering Initiative for Patient Safety-Based Consensual Qualitative Research.","authors":"Ye-Eun Park, Minsu Ock, Jae-Ho Lee, Dae-Hyun Ko, Hak-Jae Lee, Taezoon Park, Junsang Yoo, Yura Lee","doi":"10.2196/86166","DOIUrl":"10.2196/86166","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI)-enabled clinical decision support systems (CDSSs) are increasingly embedded within electronic health record (EHR) environments; however, their introduction can disrupt existing workflows and raise patient safety concerns, particularly in high-stakes settings such as surgical transfusion. Limited qualitative evidence exists regarding how frontline professionals anticipate the clinical, organizational, and workflow implications of such systems before wider deployment.</p><p><strong>Objective: </strong>This study aims to qualitatively examine the anticipated clinical, organizational, and workflow-level implications of implementing personalized Maximum Surgical Blood Order Schedule-Thoracic Surgery (pMSBOS-TS), an AI-enabled CDSS for personalized surgical blood ordering, before large-scale deployment.</p><p><strong>Methods: </strong>We conducted a consensual qualitative study with 14 multidisciplinary health care professionals involved in transfusion-related tasks at a large tertiary hospital. Following 1 pilot focus group to refine the interview guide and workflow diagram, 2 semistructured focus group discussions were held with 14 participants (5 physicians, 6 nurses, and 3 blood bank staff). Transcripts were analyzed using the Systems Engineering Initiative for Patient Safety (SEIPS) 101 framework, focusing on People, Environment, Tools, and Tasks, and were supported by task- and workflow-based analyses of transfusion processes. Member checking was conducted with participants and external clinicians to enhance validity.</p><p><strong>Results: </strong>A total of 189 semantic units and 61 core ideas were identified across 18 subdomains and 7 overarching domains. Participants anticipated that pMSBOS-TS could reduce unwarranted variation in blood ordering and planning, provided that algorithmic performance is reliable and the interface is tightly integrated into existing EHR workflows. At the same time, they expressed concerns regarding increased verification burden, system limitations in unexpected clinical scenarios, and potential communication bottlenecks between clinical units and the blood bank. Organizational culture, governance structures, and local transfusion logistics were viewed as critical determinants of whether the system would reduce or inadvertently increase workload and blood product waste.</p><p><strong>Conclusions: </strong>This preimplementation, SEIPS-based qualitative evaluation suggests that the successful adoption of an AI-enabled transfusion CDSS depends not only on predictive performance but also on sociotechnical readiness, including user trust, workflow fit, and organizational support. These findings provide practice-based insights to inform staged implementation, training, and governance strategies aimed at safely integrating predictive transfusion CDSSs into EHR-supported surgical workflows.</p>","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":"28 ","pages":"e86166"},"PeriodicalIF":6.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When Lived Experience Designs the Intervention.","authors":"Trevor van Mierlo","doi":"10.2196/91371","DOIUrl":"10.2196/91371","url":null,"abstract":"","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":"28 ","pages":"e91371"},"PeriodicalIF":6.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farhad Abtahi, Fernando Seoane, Ivan Pau, Mario Vega-Barbas
<p><strong>Background: </strong>Health care artificial intelligence (AI) systems are increasingly integrated into clinical workflows, yet remain vulnerable to data-poisoning attacks. A small number of manipulated training samples can compromise AI models used for diagnosis, documentation, and resource allocation. Existing privacy regulations, including the Health Insurance Portability and Accountability Act and the General Data Protection Regulation, may inadvertently complicate anomaly detection and cross-institutional auditing, thereby limiting visibility into adversarial activity.</p><p><strong>Objective: </strong>This study provides a comprehensive threat analysis of data poisoning vulnerabilities across major health care AI architectures. The goals are to (1) identify attack surfaces in clinical AI systems, (2) evaluate the feasibility and detectability of poisoning attacks analytically modeled in prior security research, and (3) propose a multilayered defense framework appropriate for health care settings.</p><p><strong>Methods: </strong>We synthesized empirical findings from 41 key security studies published between 2019 and 2025 and integrated them into an analytical threat-modeling framework specific to health care. We constructed 8 hypothetical yet technically grounded attack scenarios across 4 categories: (1) architecture-specific attacks on convolutional neural networks, large language models, and reinforcement learning agents (scenario A); (2) infrastructure exploitation in federated learning and clinical documentation pipelines (scenario B); (3) poisoning of critical resource allocation systems (scenario C); and (4) supply chain attacks affecting commercial foundation models (scenario D). Scenarios were aligned with realistic insider-access threat models and current clinical deployment practices.</p><p><strong>Results: </strong>Multiple empirical studies demonstrate that attackers with access to as few as 100-500 poisoned samples can compromise health care AI systems, with attack success rates typically ≥60%. Critically, attack success depends on the absolute number of poisoned samples rather than their proportion of the training corpus, a finding that fundamentally challenges assumptions that larger datasets provide inherent protection. We estimate that detection delays commonly range from 6 to 12 months and may extend to years in distributed or privacy-constrained environments. Analytical scenarios highlight that (1) routine insider access creates numerous injection points across health care data infrastructure, (2) federated learning amplifies risks by obscuring attribution, and (3) supply chain compromises can simultaneously affect dozens to hundreds of institutions. Privacy regulations further complicate cross-patient correlation and model audit processes, substantially delaying the detection of subtle poisoning campaigns.</p><p><strong>Conclusions: </strong>Health care AI systems face significant security challenges that curre
{"title":"Data Poisoning Vulnerabilities Across Health Care Artificial Intelligence Architectures: Analytical Security Framework and Defense Strategies.","authors":"Farhad Abtahi, Fernando Seoane, Ivan Pau, Mario Vega-Barbas","doi":"10.2196/87969","DOIUrl":"10.2196/87969","url":null,"abstract":"<p><strong>Background: </strong>Health care artificial intelligence (AI) systems are increasingly integrated into clinical workflows, yet remain vulnerable to data-poisoning attacks. A small number of manipulated training samples can compromise AI models used for diagnosis, documentation, and resource allocation. Existing privacy regulations, including the Health Insurance Portability and Accountability Act and the General Data Protection Regulation, may inadvertently complicate anomaly detection and cross-institutional auditing, thereby limiting visibility into adversarial activity.</p><p><strong>Objective: </strong>This study provides a comprehensive threat analysis of data poisoning vulnerabilities across major health care AI architectures. The goals are to (1) identify attack surfaces in clinical AI systems, (2) evaluate the feasibility and detectability of poisoning attacks analytically modeled in prior security research, and (3) propose a multilayered defense framework appropriate for health care settings.</p><p><strong>Methods: </strong>We synthesized empirical findings from 41 key security studies published between 2019 and 2025 and integrated them into an analytical threat-modeling framework specific to health care. We constructed 8 hypothetical yet technically grounded attack scenarios across 4 categories: (1) architecture-specific attacks on convolutional neural networks, large language models, and reinforcement learning agents (scenario A); (2) infrastructure exploitation in federated learning and clinical documentation pipelines (scenario B); (3) poisoning of critical resource allocation systems (scenario C); and (4) supply chain attacks affecting commercial foundation models (scenario D). Scenarios were aligned with realistic insider-access threat models and current clinical deployment practices.</p><p><strong>Results: </strong>Multiple empirical studies demonstrate that attackers with access to as few as 100-500 poisoned samples can compromise health care AI systems, with attack success rates typically ≥60%. Critically, attack success depends on the absolute number of poisoned samples rather than their proportion of the training corpus, a finding that fundamentally challenges assumptions that larger datasets provide inherent protection. We estimate that detection delays commonly range from 6 to 12 months and may extend to years in distributed or privacy-constrained environments. Analytical scenarios highlight that (1) routine insider access creates numerous injection points across health care data infrastructure, (2) federated learning amplifies risks by obscuring attribution, and (3) supply chain compromises can simultaneously affect dozens to hundreds of institutions. Privacy regulations further complicate cross-patient correlation and model audit processes, substantially delaying the detection of subtle poisoning campaigns.</p><p><strong>Conclusions: </strong>Health care AI systems face significant security challenges that curre","PeriodicalId":16337,"journal":{"name":"Journal of Medical Internet Research","volume":"28 ","pages":"e87969"},"PeriodicalIF":6.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}