Pub Date : 2017-07-26DOI: 10.4172/2155-9562.1000436
E. Ryding
Objective: The physiological background for intracranial pressure, ICP, increase at brain compression is presently unknown. Current knowledge of the relationship between ICP and volume of brain compression is based on animal experiments, which has led to the theory of elastic brain tissue compression, which like a loaded spring causes the ICP increase. However, tests of brain tissue composition, or compression, find no basis for elasticity, or compression. The aim of this article is to describe the physiological features controlling ICP since it is necessary for the understanding of intracranial physiology, but also since ICP is an important parameter in neurointensive care medicine. Methods: This evaluation is based on the physiological consequences of the closed intracranial compartment, the thin-walled, compressible venous bed, the auto-regulation of cerebral blood flow, CBF, to blood pressure changes, and the coupling between ICP and the intra-capillary blood pressure through the thin, flexible capillary wall. These features influence the intracranial venous blood volume, the venous vascular resistance, and the CBF. Together these features are shown to revile the ICP dependence on the volume of brain volume compression. Results: The evaluation leads to a formula that describes the relationship between ICP and changes in the brain volume. The formula predicts an exponential ICP increase at brain compression like in animal experiments but, contrary to the elastic tissue theory, a gradually higher exponential for larger compression. Conclusion: The found relationship between ICP and changes in brain volume may prove to be a useful tool in neuro-intensive care patients for following changes in intracranial volumes by the aid of continuous ICP measurements. Since brain-compressing volumes includes the arterial pulse volume, the ICP formula may also enable CBF calculation from ICP measurements. The physiological relationships leading to the description of the relationship between ICP and brain volume change may by themselves help in understanding other intracranial phenomena, like ICP plateau-waves.
{"title":"The Relationship between Intracranial Pressure Increase and Volume ofBrain Compression","authors":"E. Ryding","doi":"10.4172/2155-9562.1000436","DOIUrl":"https://doi.org/10.4172/2155-9562.1000436","url":null,"abstract":"Objective: The physiological background for intracranial pressure, ICP, increase at brain compression is presently unknown. Current knowledge of the relationship between ICP and volume of brain compression is based on animal experiments, which has led to the theory of elastic brain tissue compression, which like a loaded spring causes the ICP increase. However, tests of brain tissue composition, or compression, find no basis for elasticity, or compression. The aim of this article is to describe the physiological features controlling ICP since it is necessary for the understanding of intracranial physiology, but also since ICP is an important parameter in neurointensive care medicine. Methods: This evaluation is based on the physiological consequences of the closed intracranial compartment, the thin-walled, compressible venous bed, the auto-regulation of cerebral blood flow, CBF, to blood pressure changes, and the coupling between ICP and the intra-capillary blood pressure through the thin, flexible capillary wall. These features influence the intracranial venous blood volume, the venous vascular resistance, and the CBF. Together these features are shown to revile the ICP dependence on the volume of brain volume compression. Results: The evaluation leads to a formula that describes the relationship between ICP and changes in the brain volume. The formula predicts an exponential ICP increase at brain compression like in animal experiments but, contrary to the elastic tissue theory, a gradually higher exponential for larger compression. Conclusion: The found relationship between ICP and changes in brain volume may prove to be a useful tool in neuro-intensive care patients for following changes in intracranial volumes by the aid of continuous ICP measurements. Since brain-compressing volumes includes the arterial pulse volume, the ICP formula may also enable CBF calculation from ICP measurements. The physiological relationships leading to the description of the relationship between ICP and brain volume change may by themselves help in understanding other intracranial phenomena, like ICP plateau-waves.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78830862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-07-26DOI: 10.4172/2155-9562.1000437
M. Serra
Despite evidence for a role of nutrition in the development of metabolic dysfunction, physical deconditioning, and psychological dysfunction common post-stroke, very little is known about the dietary habits and nutritional needs of chronic (>6 months) stroke survivors. This review summarizes the available evidence regarding dietary intake adequacy in chronic stroke survivors. It appears that a combination of screening methods, including food record, laboratory and malnutrition screening tools assessments may be beneficial to assess the dietary intake adequacy of stroke survivors. We also review the evidence suggesting the need for dietary modification by summarizing the strongest evidence (i.e., randomized controlled trial data) supporting and refuting the impact of nutritional interventions on clinical outcomes post-stroke. Data suggest that the B vitamins, omega 3s and vitamin D have promising effects on recovery post-stroke; however, to date, study limitations make drawing definitive conclusions regarding the impact of nutritional supplementation difficult. Further research is needed to provide insight on the ideal supplement dose and duration and about how different rehabilitation therapies (i.e., nutritional supplements, medications, exercise and caloric restriction) may interact to affect recovery. A better understanding of the role of nutrition during chronic stroke is needed as this information may one day help to individualize rehabilitation approaches to optimize patient outcomes.
{"title":"Dietary Intake and Intervention in Chronic Stroke: Review of the Evidence","authors":"M. Serra","doi":"10.4172/2155-9562.1000437","DOIUrl":"https://doi.org/10.4172/2155-9562.1000437","url":null,"abstract":"Despite evidence for a role of nutrition in the development of metabolic dysfunction, physical deconditioning, and psychological dysfunction common post-stroke, very little is known about the dietary habits and nutritional needs of chronic (>6 months) stroke survivors. This review summarizes the available evidence regarding dietary intake adequacy in chronic stroke survivors. It appears that a combination of screening methods, including food record, laboratory and malnutrition screening tools assessments may be beneficial to assess the dietary intake adequacy of stroke survivors. We also review the evidence suggesting the need for dietary modification by summarizing the strongest evidence (i.e., randomized controlled trial data) supporting and refuting the impact of nutritional interventions on clinical outcomes post-stroke. Data suggest that the B vitamins, omega 3s and vitamin D have promising effects on recovery post-stroke; however, to date, study limitations make drawing definitive conclusions regarding the impact of nutritional supplementation difficult. Further research is needed to provide insight on the ideal supplement dose and duration and about how different rehabilitation therapies (i.e., nutritional supplements, medications, exercise and caloric restriction) may interact to affect recovery. A better understanding of the role of nutrition during chronic stroke is needed as this information may one day help to individualize rehabilitation approaches to optimize patient outcomes.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"11 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72641333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-07-15DOI: 10.4172/2155-9562.1000435
S. Mitra, S. Kataria
Whole-brain radiation therapy has been the standard form of treatment for advanced cancers, metastatic to the brain. It has the advantage of easy availability and delivery, and effectiveness in offering relief from symptoms for many suitable patients. Since most of these patients have poor outcomes and limited survival, oncologists in the past had a nihilistic approach and as a result, the potential toxicities emerging from WBRT have been largely neglected. With advances been made in neurosurgery, imaging, medical and radiation oncology, the results for many patients have improved significantly, particularly for those having favorable prognostic factors. Hence, the use of WBRT has come under scrutiny, due to its potential effect on the neurocognitive functions of the patient and their quality of life. This review article attempts to investigate if the various Neurocognitive sparing radiotherapy procedures can become a standard radiotherapy method for selected patients receiving whole brain radiotherapy for metastatic disease.
{"title":"Emerging Role of Neurocognitive Sparing Radiotherapy: Can it be the NewStandard of Care?","authors":"S. Mitra, S. Kataria","doi":"10.4172/2155-9562.1000435","DOIUrl":"https://doi.org/10.4172/2155-9562.1000435","url":null,"abstract":"Whole-brain radiation therapy has been the standard form of treatment for advanced cancers, metastatic to the brain. It has the advantage of easy availability and delivery, and effectiveness in offering relief from symptoms for many suitable patients. Since most of these patients have poor outcomes and limited survival, oncologists in the past had a nihilistic approach and as a result, the potential toxicities emerging from WBRT have been largely neglected. With advances been made in neurosurgery, imaging, medical and radiation oncology, the results for many patients have improved significantly, particularly for those having favorable prognostic factors. Hence, the use of WBRT has come under scrutiny, due to its potential effect on the neurocognitive functions of the patient and their quality of life. This review article attempts to investigate if the various Neurocognitive sparing radiotherapy procedures can become a standard radiotherapy method for selected patients receiving whole brain radiotherapy for metastatic disease.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"32 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84398991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-07-10DOI: 10.4172/2155-9562.1000433
M. Radoi, Ram Vakilnejad, L. Gheorghitescu, F. Stefanescu
Intracranial chondromas are rare skull base tumors, but those arising from the falx cerebri are extremely rare. Of our knowledge, there have been reported no more than seventeen cases. Surgical gross removal of falx chondroma is associated with good outcome. We bring into focus the case of a large falcine chondroma and discuss its diagnosis, surgical management and prognosis.
{"title":"Falx Cerebri Giant Chondroma — Case Report","authors":"M. Radoi, Ram Vakilnejad, L. Gheorghitescu, F. Stefanescu","doi":"10.4172/2155-9562.1000433","DOIUrl":"https://doi.org/10.4172/2155-9562.1000433","url":null,"abstract":"Intracranial chondromas are rare skull base tumors, but those arising from the falx cerebri are extremely rare. Of our knowledge, there have been reported no more than seventeen cases. Surgical gross removal of falx chondroma is associated with good outcome. We bring into focus the case of a large falcine chondroma and discuss its diagnosis, surgical management and prognosis.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83235833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-07-10DOI: 10.4172/2155-9562.1000434
M. HelbertdeOliveira, uca Palmiero, R. Wainberg, R. Caramanti, C. A. Filho, F. Chaddad
Introduction: PICA aneurysms answer for 3% of all intracranial aneurysms. The patients generally present Hunt- Hess I or II and have intraventricular hemorrhage needing treatment. Case presentation: This is a case study about an elderly woman complaining about a sudden headache. She had an aneurysm in the distal segment of the PICA, which was treated by clipping. The woman progressed well despite her hydrocephalus. Discussion: Information about the aneurysm positioning and anatomy guided the therapeutic decisions. Age and clinical presentation are the most prominent factors in positive clinical evolution. An interdisciplinary team should choose between surgical and endovascular treatment.
{"title":"Posterior Inferior Cerebellar Artery Aneurysm: Surgical or EndovascularTreatment in a Case Report","authors":"M. HelbertdeOliveira, uca Palmiero, R. Wainberg, R. Caramanti, C. A. Filho, F. Chaddad","doi":"10.4172/2155-9562.1000434","DOIUrl":"https://doi.org/10.4172/2155-9562.1000434","url":null,"abstract":"Introduction: PICA aneurysms answer for 3% of all intracranial aneurysms. The patients generally present Hunt- Hess I or II and have intraventricular hemorrhage needing treatment. Case presentation: This is a case study about an elderly woman complaining about a sudden headache. She had an aneurysm in the distal segment of the PICA, which was treated by clipping. The woman progressed well despite her hydrocephalus. Discussion: Information about the aneurysm positioning and anatomy guided the therapeutic decisions. Age and clinical presentation are the most prominent factors in positive clinical evolution. An interdisciplinary team should choose between surgical and endovascular treatment.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"337 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80653260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-30DOI: 10.4172/2155-9562.1000432
S. Viswanathan, Carol Lai, S. Ling, S. Yusoff, N. Rose
There are very few cases in the literature on spinal cryptococcomas occurring alone without cerebral involvement at onset. Although cases of cerebral cryptoccomas followed by arachnoiditis have been reported, cases of spinal cryptococcoma followed by cryptococcal meningitis are exceedingly rare. We present a patient with spinal cord cryptococcoma who subsequently developed cryptococcal meningitis in a young immunocompetent patient. Early recognition and aggressive anti-fungal treatment is important.
{"title":"Spinal Cryptococcoma Mimicking Spinal Cord Tumor Complicated byCryptococcal Meningitis in an Immunocompetent Patient","authors":"S. Viswanathan, Carol Lai, S. Ling, S. Yusoff, N. Rose","doi":"10.4172/2155-9562.1000432","DOIUrl":"https://doi.org/10.4172/2155-9562.1000432","url":null,"abstract":"There are very few cases in the literature on spinal cryptococcomas occurring alone without cerebral involvement at onset. Although cases of cerebral cryptoccomas followed by arachnoiditis have been reported, cases of spinal cryptococcoma followed by cryptococcal meningitis are exceedingly rare. We present a patient with spinal cord cryptococcoma who subsequently developed cryptococcal meningitis in a young immunocompetent patient. Early recognition and aggressive anti-fungal treatment is important.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"41 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74200718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-29DOI: 10.4172/2155-9562.1000430
Damiani Sabino, Marvulli Riccardo, D. Maria, Gallo Giulia Alessia, S. Andrea, Fiore Pietro, Megna Marisa
Introduction: Primary focus of research in psychology, neuropsychology and neuroscience within the past few decades understands what consciousness means biologically and psychologically for information present in it that is on determining the neural and psychological correlates of consciousness. This retrospective study evaluated the correlation between clinical examination and neuroradiological imaging in patients with disorder of consciousness (DOC), for predicting the likely outcome of one's current standing. Materials and methods: Six patients (4 men and 2 female) suffered of DOC post-coma, outcome of severe acquired brain injuries were examined in acute phase with brain (scan) CAT (computerized axial tomography) and/ or fMRI (functional magnetic resonance imaging). After, they were evaluated with electroencephalogram and fMRI. Repeated clinical assessments were conducted with neurological examination and rating scales such as Glasgow Coma Scale (GCS) and Disability Rating Scale (DRS) at the beginning (T1), middle (T2) and end (T3) of hospitalization. 2/6 patients died. Discussion: Clinical evaluation performed with rating scales of consciousness and disability degree, showed in all patients an increase of absolute value of GCS and a reduction of DRS. We obtained most interesting observations concerning the relationship between the prognosis and patient characteristics with functional MRI. Conclusion: Although the few numbers of patients and the limits of methodological problems, our study, in accordance with previous evidence from the literature, may confirm the central role of nature of brain injuries as the prediction marker for the and fMRI direct visualization of the areas of cortical activation.
{"title":"Prognostic and Diagnostic Value of Clinical Examination and fMRI in theEvaluation of Patients in a Vegetative State","authors":"Damiani Sabino, Marvulli Riccardo, D. Maria, Gallo Giulia Alessia, S. Andrea, Fiore Pietro, Megna Marisa","doi":"10.4172/2155-9562.1000430","DOIUrl":"https://doi.org/10.4172/2155-9562.1000430","url":null,"abstract":"Introduction: Primary focus of research in psychology, neuropsychology and neuroscience within the past few decades understands what consciousness means biologically and psychologically for information present in it that is on determining the neural and psychological correlates of consciousness. This retrospective study evaluated the correlation between clinical examination and neuroradiological imaging in patients with disorder of consciousness (DOC), for predicting the likely outcome of one's current standing. Materials and methods: Six patients (4 men and 2 female) suffered of DOC post-coma, outcome of severe acquired brain injuries were examined in acute phase with brain (scan) CAT (computerized axial tomography) and/ or fMRI (functional magnetic resonance imaging). After, they were evaluated with electroencephalogram and fMRI. Repeated clinical assessments were conducted with neurological examination and rating scales such as Glasgow Coma Scale (GCS) and Disability Rating Scale (DRS) at the beginning (T1), middle (T2) and end (T3) of hospitalization. 2/6 patients died. Discussion: Clinical evaluation performed with rating scales of consciousness and disability degree, showed in all patients an increase of absolute value of GCS and a reduction of DRS. We obtained most interesting observations concerning the relationship between the prognosis and patient characteristics with functional MRI. Conclusion: Although the few numbers of patients and the limits of methodological problems, our study, in accordance with previous evidence from the literature, may confirm the central role of nature of brain injuries as the prediction marker for the and fMRI direct visualization of the areas of cortical activation.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"19 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2017-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84545910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-19DOI: 10.4172/2155-9562.1000431
Bikila Gedefa, T. Menna, T. Berhe, H. Abera
Background: Stroke is becoming a significant cause of morbidity and mortality in low and middle income countries. Currently, there is limited data about stroke in Ethiopia to design a strategy to combat the disease. Objective: To assess the overall prevalence, potential risk factors and outcome of stroke admissions at St. Paul’s Teaching Referral Hospital. Patients and methods: A hospital based retrospective study was conducted at St. Paul’s Teaching Referral Hospital in April 2016. The study has focused on review of medical records of all stroke admissions to the hospital from September 1st, 2015 to August 30th, 2016. Socio-demographic information, risk factors, and treatment outcomes of patients were assessed and data were entered and analyzed using Statistical Programs for Social Sciences 23.0. Descriptive analysis and Chi-square tests were used to assess the association between sociodemographic variables, potential risk factors and treatment outcomes of patients with stroke. P-value<0.05 was considered significant. Results: A total of 163 stroke patients with a median age of 68 years and M:F ratios of 1.3:1 were analyzed. Hemorrhagic stroke was the most common type of stroke accounting for 61.3% of cases. The most commonly identified risk factors were; Hypertension (60.7%), structural heart disease (18.4%), atrial fibrillation (14.7%) and diabetes mellitus (11%). In hospital case fatality rate was 30.1% and a significant number (45.4%) of patients was discharged with neurologic deficit and the median duration of hospital stay was 11.14 days. Conclusion: In this study, hemorrhagic stroke was the most common type of stroke. Gender, stroke subtype, previous history of stroke and transient ischemic attack were the main determinants of treatment outcome.
{"title":"Assessment of Risk Factors and Treatment Outcome of Stroke Admissions at St. Paul's Teaching Hospital, Addis Ababa, Ethiopia","authors":"Bikila Gedefa, T. Menna, T. Berhe, H. Abera","doi":"10.4172/2155-9562.1000431","DOIUrl":"https://doi.org/10.4172/2155-9562.1000431","url":null,"abstract":"Background: Stroke is becoming a significant cause of morbidity and mortality in low and middle income countries. Currently, there is limited data about stroke in Ethiopia to design a strategy to combat the disease. Objective: To assess the overall prevalence, potential risk factors and outcome of stroke admissions at St. Paul’s Teaching Referral Hospital. Patients and methods: A hospital based retrospective study was conducted at St. Paul’s Teaching Referral Hospital in April 2016. The study has focused on review of medical records of all stroke admissions to the hospital from September 1st, 2015 to August 30th, 2016. Socio-demographic information, risk factors, and treatment outcomes of patients were assessed and data were entered and analyzed using Statistical Programs for Social Sciences 23.0. Descriptive analysis and Chi-square tests were used to assess the association between sociodemographic variables, potential risk factors and treatment outcomes of patients with stroke. P-value<0.05 was considered significant. Results: A total of 163 stroke patients with a median age of 68 years and M:F ratios of 1.3:1 were analyzed. Hemorrhagic stroke was the most common type of stroke accounting for 61.3% of cases. The most commonly identified risk factors were; Hypertension (60.7%), structural heart disease (18.4%), atrial fibrillation (14.7%) and diabetes mellitus (11%). In hospital case fatality rate was 30.1% and a significant number (45.4%) of patients was discharged with neurologic deficit and the median duration of hospital stay was 11.14 days. Conclusion: In this study, hemorrhagic stroke was the most common type of stroke. Gender, stroke subtype, previous history of stroke and transient ischemic attack were the main determinants of treatment outcome.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"24 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85612914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-07DOI: 10.4172/2155-9562.1000426
A. Ionescu, G. Butoi, S. Chirila, Bălan Corneliu, H. Anca
Ganglioneuromas are rare tumors, known as neuroblastic or neurogenic tumors, which most often start in autonomic nerve cells, which may be found in any part of the body. We present a case of 53 years old, woman, with mild arterial hypertension, who has right sided hemiparesis, more on the leg, with gradual onset. Cerebral MRI was normal. After a few months, she developed motor deficit on the opposite leg, with the picture of triparesis and impairment of walking. MRI of the cervical spine was showing an extra medullary intradural mass C5-C6-C7 and she finally underwent extended cervical laminectomy from C-5 to C-7 level, and total ablation of the tumor. Despite the first supposition of a neurinoma, histopathology examination confirmed a case of ganglioneuroma tumor. In a few weeks, she became confused and with impairment of gait. An obstructive hydrocephalus was confirmed on CT scan. The ventriculo-peritoneal shunt was performed and the recovery was complete.
{"title":"Cervical Ganglioneuroma and Obstructive Hydrocephalus Following Surgery - A Rare Association","authors":"A. Ionescu, G. Butoi, S. Chirila, Bălan Corneliu, H. Anca","doi":"10.4172/2155-9562.1000426","DOIUrl":"https://doi.org/10.4172/2155-9562.1000426","url":null,"abstract":"Ganglioneuromas are rare tumors, known as neuroblastic or neurogenic tumors, which most often start in autonomic nerve cells, which may be found in any part of the body. We present a case of 53 years old, woman, with mild arterial hypertension, who has right sided hemiparesis, more on the leg, with gradual onset. Cerebral MRI was normal. After a few months, she developed motor deficit on the opposite leg, with the picture of triparesis and impairment of walking. MRI of the cervical spine was showing an extra medullary intradural mass C5-C6-C7 and she finally underwent extended cervical laminectomy from C-5 to C-7 level, and total ablation of the tumor. Despite the first supposition of a neurinoma, histopathology examination confirmed a case of ganglioneuroma tumor. In a few weeks, she became confused and with impairment of gait. An obstructive hydrocephalus was confirmed on CT scan. The ventriculo-peritoneal shunt was performed and the recovery was complete.","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"13 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78999318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-07DOI: 10.4172/2155-9562.1000429
S. C. Kim, W. Im, Beom Jin Kim
Biomagnetism is one of important biotechnology fields for manipulation of cell lines. However, its peri-cellular level regulation, upon stimulation is not fully developed. Glioblastoma U87 and U251 represent a malignant model in rapid growing cancer. We focused in cellular level dispersion of static magnetic fields (0.2T=2000 ± 600 Gauss), using its fast growing properties. As a result, cytoskeletal protein nuclear Ankyrin G was dispersed. Membrane barriers in TEM microscopy indicated the membranous apparatus change. Our findings bring an insight that static magnetic stimulation creates a specified cytoplasmic intracellular pattern
{"title":"Low Intensity (0.2T) Static Magnetic Field for Dispersing Nucleus AnkyrinG in Human Cultured Glioblastoma Cells","authors":"S. C. Kim, W. Im, Beom Jin Kim","doi":"10.4172/2155-9562.1000429","DOIUrl":"https://doi.org/10.4172/2155-9562.1000429","url":null,"abstract":"Biomagnetism is one of important biotechnology fields for manipulation of cell lines. However, its peri-cellular level regulation, upon stimulation is not fully developed. Glioblastoma U87 and U251 represent a malignant model in rapid growing cancer. We focused in cellular level dispersion of static magnetic fields (0.2T=2000 ± 600 Gauss), using its fast growing properties. As a result, cytoskeletal protein nuclear Ankyrin G was dispersed. Membrane barriers in TEM microscopy indicated the membranous apparatus change. Our findings bring an insight that static magnetic stimulation creates a specified cytoplasmic intracellular pattern","PeriodicalId":16455,"journal":{"name":"Journal of Neurology and Neurophysiology","volume":"9 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84998794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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