Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30904-X
Li Yu , Xiong Chan , Qin Erqi , Li Lin , Zhuang Guangtong , Yu Zheng
OBJECTIVE
To assess the curative effect of Traditional Chinese Medicine (TCM) on leukopenia induced by chemo-radiotherapy in patients with lung cancer.
METHODS
A comprehensive electronic search in Medline, Embase, the Cochrane Libary database, China National Knowledge Infrastructure Database (CNKI) and Wanfang Database was conducted up to July 2017. Random-effects model was used to estimate the standardized mean differences (SMDs) with 95% confidence intervals (CIs). Eleven studies with a total of 957 patients were included in this meta-analysis.
RESULTS
The effectiveness in TCM group was higher than control group [RR = 1.60, 95% CI (1.38, 1.85), P < 0.000 01]. Compare with Western Medicine group, the effectiveness has no significant difference [RR = 0.96, 95% CI (0.82, 1.12), P = 0.57]. The ineffective rate in test group was lower than the control group [RR = 0.30, 95% CI (0.21, 0.42), P < 0.000 01].
CONCLUSION
By meta-regression it was suggested that TCM has curative effect on leukopenia induced by chemo-radiotherapy in patients with lung cancer, but by the influence of number and quality of researches, publication bias, more evidence from high quality studies, and larger cohorts for observational trials are needed.
目的探讨中药治疗肺癌放化疗所致白细胞减少症的疗效。方法截至2017年7月，在Medline、Embase、Cochrane library数据库、中国知网(CNKI)和万方数据库中进行综合电子检索。采用随机效应模型估计标准化平均差(SMDs)，置信区间为95%。这项荟萃分析纳入了11项研究，共957例患者。结果中药组有效率高于对照组[RR = 1.60, 95% CI (1.38, 1.85)， P <0.000 01]。与西药组比较，疗效无显著差异[RR = 0.96, 95% CI (0.82, 1.12)， P = 0.57]。试验组无效率低于对照组[RR = 0.30, 95% CI (0.21, 0.42)， P <0.000 01]。结论经meta回归分析，中药对肺癌放化疗所致白细胞减少有疗效，但受研究数量和质量的影响，存在发表偏倚，需要更多高质量研究的证据，需要更大的观察性试验队列。
{"title":"Effectiveness of Traditional Chinese Medicine on chemo-radiotherapy induced leukaemia in patients with lung cancer: a Meta-analysis","authors":"Li Yu , Xiong Chan , Qin Erqi , Li Lin , Zhuang Guangtong , Yu Zheng","doi":"10.1016/S0254-6272(18)30904-X","DOIUrl":"10.1016/S0254-6272(18)30904-X","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To assess the curative effect of Traditional Chinese Medicine (TCM) on leukopenia induced by chemo-radiotherapy in patients with lung cancer.</p></div><div><h3>METHODS</h3><p>A comprehensive electronic search in Medline, Embase, the Cochrane Libary database, China National Knowledge Infrastructure Database (CNKI) and Wanfang Database was conducted up to July 2017. Random-effects model was used to estimate the standardized mean differences (<em>SMD</em>s) with 95% confidence intervals (<em>CI</em>s). Eleven studies with a total of 957 patients were included in this meta-analysis.</p></div><div><h3>RESULTS</h3><p>The effectiveness in TCM group was higher than control group [<em>RR</em> = 1.60, 95% <em>CI</em> (1.38, 1.85), <em>P</em> < 0.000 01]. Compare with Western Medicine group, the effectiveness has no significant difference [<em>RR</em> = 0.96, 95% <em>CI</em> (0.82, 1.12), <em>P</em> = 0.57]. The ineffective rate in test group was lower than the control group [<em>RR</em> = 0.30, 95% <em>CI</em> (0.21, 0.42), <em>P</em> < 0.000 01].</p></div><div><h3>CONCLUSION</h3><p>By meta-regression it was suggested that TCM has curative effect on leukopenia induced by chemo-radiotherapy in patients with lung cancer, but by the influence of number and quality of researches, publication bias, more evidence from high quality studies, and larger cohorts for observational trials are needed.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30904-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85348733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30909-9
Zeng Jinhao , Pan Huafeng , Guo Jing , Gong Daoyin , Cai Tiantian , Chen Xiaodong , Zhang Yi , You Fengming , Chen Longhui , Zhao Ziming , Liang Chao
OBJECTIVE
To investigate the mechanism underlying the action of Weipixiao (WPX) in a rat's model with ameliorating gastric precancerous lesions (GPL).
METHODS
HPLC analysis was performed to identify the chemical constituents of WPX preparation. Sprague- Dawley rats were randomly assigned into control group, model group, vitacoenzyme group, high-dose WPX group (H-WPX), medium-dose WPX group (M-WPX) and low-dose WPX group (L-WPX). After modeling, the treated rats were administrated WPX or vitacoenzyme intragastrically for consecutive 10 weeks. Gene and protein expressions of GSK3β, C-myc, Cylin E were evaluated by quantitative real-time reverse transcription-polymerase chain reaction (RT-qPCR) and immunohistochemistry, respectively.
RESULTS
WPX could efficiently attenuate the pathological alterations of “non-progressive GPL” in rats. As expected, mRNA and protein levels of C-myc and Cylin E were up-regulated in model rats, while GSK3β expression down-regulated (P < 0.01). WPX treatment, especially at low dose, could significantly down-regulate the mRNA as well as protein levels of C-myc, and could lead to remarkable up-regulation of mRNA and protein levels of GSK3β in GPL rats (P < 0.05). However, no significant changes were observed in WPX-treated rats.
CONCLUSION
Our findings suggested that WPX-mediated attenuation of GPL pathological alterations might be due to its regulatory effect on the expressions of GSK3β and C-myc, and on the dysregulation of Wnt/GSK3β pathway.
{"title":"Weipixiao ameliorates gastric precancerous lesions in a rat's model by regulating GSK3β and C-myc","authors":"Zeng Jinhao , Pan Huafeng , Guo Jing , Gong Daoyin , Cai Tiantian , Chen Xiaodong , Zhang Yi , You Fengming , Chen Longhui , Zhao Ziming , Liang Chao","doi":"10.1016/S0254-6272(18)30909-9","DOIUrl":"10.1016/S0254-6272(18)30909-9","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the mechanism underlying the action of Weipixiao (WPX) in a rat's model with ameliorating gastric precancerous lesions (GPL).</p></div><div><h3>METHODS</h3><p>HPLC analysis was performed to identify the chemical constituents of WPX preparation. Sprague- Dawley rats were randomly assigned into control group, model group, vitacoenzyme group, high-dose WPX group (H-WPX), medium-dose WPX group (M-WPX) and low-dose WPX group (L-WPX). After modeling, the treated rats were administrated WPX or vitacoenzyme intragastrically for consecutive 10 weeks. Gene and protein expressions of GSK3β, C-myc, Cylin E were evaluated by quantitative real-time reverse transcription-polymerase chain reaction (RT-qPCR) and immunohistochemistry, respectively.</p></div><div><h3>RESULTS</h3><p>WPX could efficiently attenuate the pathological alterations of “non-progressive GPL” in rats. As expected, mRNA and protein levels of C-myc and Cylin E were up-regulated in model rats, while GSK3β expression down-regulated (<em>P</em> < 0.01). WPX treatment, especially at low dose, could significantly down-regulate the mRNA as well as protein levels of C-myc, and could lead to remarkable up-regulation of mRNA and protein levels of GSK3β in GPL rats (<em>P</em> < 0.05). However, no significant changes were observed in WPX-treated rats.</p></div><div><h3>CONCLUSION</h3><p>Our findings suggested that WPX-mediated attenuation of GPL pathological alterations might be due to its regulatory effect on the expressions of GSK3β and C-myc, and on the dysregulation of Wnt/GSK3β pathway.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30909-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41318371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30918-X
Tan Yong , Shen Shanshan , Guan Fulan , He Bing , Lu Cheng , Xiao Cheng , Jiang Miao , Zhao Ning , Li Li , Cheng Shiping , Zu Xianpeng , Zhang Weidong , Liu Xinru , Lü Aiping
OBJECTIVE
To investigate the metabolic pathogenesis in subjects with subjective tinnitus (ST) having kidney deficiency pattern (KDP) (ST/KDP) in terms of Traditional Chinese Medicine.
METHODS
Three groups of subjects, including healthy individuals, subjects with ST/KDP, and subjects who were healthy initially and then developed ST/KDP one year later (healthy → ST/KDP), were recruited for this study. Serum metabolic profiles of all subjects were analyzed using ultra-performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry. The metabolic characteristics of the ST/KDP subjects were determined, and the corresponding biomarkers were predicted. The metabolomics data from the healthy → ST/KDP subjects were collected for further verification.
RESULTS
Twelve metabolites in the ST/KDP subjects were different from those of the healthy control subjects. Of these metabolites, according to the prediction, except for octanoic acid, other metabolites might characterize ST/KDP. Ten metabolites at the outcome ST/KDP stage were different from those at the initial (control) stage. Through the comparison of these metabolites with the predicted metabolites, five common metabolites, including upregulated glutamate, serotonin, orotic acid and 8-oxoguanine, as well as downregulated taurine, were found. These common metabolites were significantly associated with canonical pathways including calcium signaling, γ-aminobutyric acid (GABA) receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling.
CONCLUSION
The metabolic pathogenesis in ST/KDP subjects was characterized by upregulated glutamate, serotonin, orotic acid and 8-oxoguanine, as well as downregulated taurine, additionally, perturbations of calcium signaling, GABA receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling.
{"title":"Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles","authors":"Tan Yong , Shen Shanshan , Guan Fulan , He Bing , Lu Cheng , Xiao Cheng , Jiang Miao , Zhao Ning , Li Li , Cheng Shiping , Zu Xianpeng , Zhang Weidong , Liu Xinru , Lü Aiping","doi":"10.1016/S0254-6272(18)30918-X","DOIUrl":"10.1016/S0254-6272(18)30918-X","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the metabolic pathogenesis in subjects with subjective tinnitus (ST) having kidney deficiency pattern (KDP) (ST/KDP) in terms of Traditional Chinese Medicine.</p></div><div><h3>METHODS</h3><p>Three groups of subjects, including healthy individuals, subjects with ST/KDP, and subjects who were healthy initially and then developed ST/KDP one year later (healthy → ST/KDP), were recruited for this study. Serum metabolic profiles of all subjects were analyzed using ultra-performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry. The metabolic characteristics of the ST/KDP subjects were determined, and the corresponding biomarkers were predicted. The metabolomics data from the healthy → ST/KDP subjects were collected for further verification.</p></div><div><h3>RESULTS</h3><p>Twelve metabolites in the ST/KDP subjects were different from those of the healthy control subjects. Of these metabolites, according to the prediction, except for octanoic acid, other metabolites might characterize ST/KDP. Ten metabolites at the outcome ST/KDP stage were different from those at the initial (control) stage. Through the comparison of these metabolites with the predicted metabolites, five common metabolites, including upregulated glutamate, serotonin, orotic acid and 8-oxoguanine, as well as downregulated taurine, were found. These common metabolites were significantly associated with canonical pathways including calcium signaling, γ-aminobutyric acid (GABA) receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling.</p></div><div><h3>CONCLUSION</h3><p>The metabolic pathogenesis in ST/KDP subjects was characterized by upregulated glutamate, serotonin, orotic acid and 8-oxoguanine, as well as downregulated taurine, additionally, perturbations of calcium signaling, GABA receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30918-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85539195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30917-8
JiEun Lee , Seung-Yeon Cho , Seong-Uk Park , Woo-Sang Jung , Sang-Kwan Moon , Jung-Mi Park , Chang-Nam Ko , Ki-Ho Cho , Seungwon Kwon
OBJECTIVE
To show whether Danggui Sini plus Wuzhuyu Shengjiang Tang (DSWST) has any transient effect on erythrocyte deformability in normal subjects.
METHODS
A total of 25 subjects [mean age (27.8 ± 1.8) years] was enrolled in this study. The study was designed as a cross-over trial in which the subjects took part for 2 d. On the first day, blood samples were collected at baseline and 1-2 h after administration of water, whereas, on the second day, instead of water, the subjects were administered DSWST after the baseline blood sampling. The blood samples collected at baseline and after the administration water or DSWST, were examined for erythrocyte deformability.
RESULTS
The elongation index increased significantly after 2 h (P = 0.009) compared to the baseline after DSWST intake. However, after water intake, there was no significant difference observed. When comparing the percent change of erythrocyte deformability between DSWST and water, we found that after 2 h of administration, DSWST improved erythrocyte deformability significantly compared to water (P < 0.001).
CONCLUSION
DSWST has a transient effect on erythrocyte deformability in normal subjects.
{"title":"Effect of the herbal medicine Danggui Sini plus Wuzhuyu Shengjiang Tang on erythrocyte deformability in normal subjects: a cross-over trial","authors":"JiEun Lee , Seung-Yeon Cho , Seong-Uk Park , Woo-Sang Jung , Sang-Kwan Moon , Jung-Mi Park , Chang-Nam Ko , Ki-Ho Cho , Seungwon Kwon","doi":"10.1016/S0254-6272(18)30917-8","DOIUrl":"10.1016/S0254-6272(18)30917-8","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To show whether Danggui Sini plus Wuzhuyu Shengjiang Tang (DSWST) has any transient effect on erythrocyte deformability in normal subjects.</p></div><div><h3>METHODS</h3><p>A total of 25 subjects [mean age (27.8 ± 1.8) years] was enrolled in this study. The study was designed as a cross-over trial in which the subjects took part for 2 d. On the first day, blood samples were collected at baseline and 1-2 h after administration of water, whereas, on the second day, instead of water, the subjects were administered DSWST after the baseline blood sampling. The blood samples collected at baseline and after the administration water or DSWST, were examined for erythrocyte deformability.</p></div><div><h3>RESULTS</h3><p>The elongation index increased significantly after 2 h (<em>P</em> = 0.009) compared to the baseline after DSWST intake. However, after water intake, there was no significant difference observed. When comparing the percent change of erythrocyte deformability between DSWST and water, we found that after 2 h of administration, DSWST improved erythrocyte deformability significantly compared to water (<em>P</em> < 0.001).</p></div><div><h3>CONCLUSION</h3><p>DSWST has a transient effect on erythrocyte deformability in normal subjects.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30917-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47814723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30920-8
Lin Jing , Zhu Jun , Tian Fubo , Chen Lanting , Zhang Yang , Wang Yan , Wang Mingyan , Hans-Jürgen Gober , Li Dajin , Wang Ling
OBJECTIVE
To determine the therapeutic effect of Ziyin Jianghuo Ningxin Decoction (ZYJHNXD) plus dehydroepiandrosterone (DHEA) and menopausal hormone therapy (MHT) in patients suffering from menopausal symptoms identified as, in terms of Traditional Chinese Medicine, symptom pattern of Yin deficiency with hyperactive fire.
METHODS
Totally 180 postmenopausal women aged 40 to 60 years were assigned into four groups and accepted femoston, femoston with ZYJHNXD, femoston with DHEA, femoston with ZYJHNXD and DHEA therapies, respectively, for three months. Common questionnaire-based measure instruments included modified Kupperman index (MKI), Hamilton Rating Scale for Anxiety (HAMA), and Hamilton Rating Scale for Depression (HAMD). Follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), 5-hydroxyindole-3-acetic acid (5-HIAA), norepinephrine (NE), dopamine (DA), bone mineral density (BMD), and sleep quality were evaluated before and three months after the treatments.
RESULTS
In all four groups, the scores of MKI, HAMA, HAMD and the levels of FSH, LH decreased significantly (P < 0.05) after the treatment, while the levels of E2, 5-HIAA, NE, and DA showed obvious elevation (P < 0.05). The group receiving ZYJHNXD and DHEA combined with femoston had superiority in the preservation of bone mineral density and improvement of total sleep time and nighttime sleep time over the other three groups.
CONCLUSION
ZYJHNXD and DHEA combined with MHT therapy have a favorable outcome in managing menopausal symptoms, restoring hormone levels, preventing skeletal rarefaction or osteoporosis, and improving sleep quality for postmenopausal women.
{"title":"Effects of Ziyin Jianghuo Ningxin decoction plus dehydroepiandrosterone and femoston in treatment of patients with menopausal symptoms","authors":"Lin Jing , Zhu Jun , Tian Fubo , Chen Lanting , Zhang Yang , Wang Yan , Wang Mingyan , Hans-Jürgen Gober , Li Dajin , Wang Ling","doi":"10.1016/S0254-6272(18)30920-8","DOIUrl":"10.1016/S0254-6272(18)30920-8","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To determine the therapeutic effect of Ziyin Jianghuo Ningxin Decoction (ZYJHNXD) plus dehydroepiandrosterone (DHEA) and menopausal hormone therapy (MHT) in patients suffering from menopausal symptoms identified as, in terms of Traditional Chinese Medicine, symptom pattern of <em>Yin</em> deficiency with hyperactive fire.</p></div><div><h3>METHODS</h3><p>Totally 180 postmenopausal women aged 40 to 60 years were assigned into four groups and accepted femoston, femoston with ZYJHNXD, femoston with DHEA, femoston with ZYJHNXD and DHEA therapies, respectively, for three months. Common questionnaire-based measure instruments included modified Kupperman index (MKI), Hamilton Rating Scale for Anxiety (HAMA), and Hamilton Rating Scale for Depression (HAMD). Follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), 5-hydroxyindole-3-acetic acid (5-HIAA), norepinephrine (NE), dopamine (DA), bone mineral density (BMD), and sleep quality were evaluated before and three months after the treatments.</p></div><div><h3>RESULTS</h3><p>In all four groups, the scores of MKI, HAMA, HAMD and the levels of FSH, LH decreased significantly (<em>P</em> < 0.05) after the treatment, while the levels of E2, 5-HIAA, NE, and DA showed obvious elevation (<em>P</em> < 0.05). The group receiving ZYJHNXD and DHEA combined with femoston had superiority in the preservation of bone mineral density and improvement of total sleep time and nighttime sleep time over the other three groups.</p></div><div><h3>CONCLUSION</h3><p>ZYJHNXD and DHEA combined with MHT therapy have a favorable outcome in managing menopausal symptoms, restoring hormone levels, preventing skeletal rarefaction or osteoporosis, and improving sleep quality for postmenopausal women.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30920-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41914128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30906-3
Cui Yiran , Wu Hongwei , Liu Mengting , Qin Haijiao , Liu Xin , Yang Hongjun
OBJECTIVE
To investigate the effect of Ginkgo biloba leaf extract on amino acid levels in the cerebral cortex of cerebral ischemia model rats induced by middle cerebral artery occlusion (MCAO).
METHODS
A rat model of cerebral ischemia was established by MCAO. Male rats were divided into a negative control group (Control), a sham-operated group (Sham), an ischemic group (MCAO), and an ischemic group treated with Ginkgo biloba leaf extract (MCAO_D). All groups were divided into two subgroups with occlusion times of 12 and 24 h, respectively. The levels of 18 endogenous amino acids in the cerebral cortex were quantified by triple quadrupole-liquid chromatography-mass spectrometry.
RESULTS
Compared with the MCAO group, behavioral performance, neurological deficit score, and cerebral infarct volume were significantly improved in the MCAO_D group (P < 0.05, P < 0.01). Compared with the sham group, the levels of 17 amino acids in the cerebral cortex were markedly changed in the MCAO group. The levels of Alanine (Ala), Isoleucine (Ile), Glutamic acid (Glu), Serine (Ser), Valine (Val), Phenylalanine (Phe), Proline (Pro), Threonine (Thr), Lysine (Lys), Tyrosine (Tyr), Hydroxyproline (Hyp), Arginine (Arg), Leucine (Leu), Tryptophan (Trp), and Glycine (Gly) were increased (P < 0.001, P < 0.05), while levels of Gln and Tau were decreased (P < 0.001, P < 0.05). Compared with the MCAO group, Ginkgo biloba extract treatment in the MCAO_D group significantly down-regulated the levels of 11 amino acids, especially those of Arg, Thr, and Ser in 12 or 24 h.
CONCLUSION
Injection of Ginkgo biloba leaf extract has a therapeutic effect on model rats with MCAO-induced cerebral ischemia by acting on amino acids in the cerebral cortex. This effect might be associated with the regulation of amino acid metabolism in the cerebral cortex.
目的探讨银杏叶提取物对大脑中动脉闭塞(MCAO)致脑缺血模型大鼠大脑皮层氨基酸水平的影响。方法采用MCAO建立大鼠脑缺血模型。将雄性大鼠分为阴性对照组(control)、假手术组(Sham)、缺血组(MCAO)和银杏叶提取物缺血组(MCAO_D)。各组均分为2个亚组，阻断时间分别为12和24 h。采用三重四极柱-液相色谱-质谱联用法定量测定大鼠大脑皮层中18种内源氨基酸的含量。结果与MCAO组比较，MCAO_D组大鼠行为表现、神经功能缺损评分、脑梗死体积均显著改善(P <0.05, P <0.01)。与假手术组比较，MCAO组大鼠大脑皮层17种氨基酸水平明显改变。丙氨酸(Ala)、异亮氨酸(Ile)、谷氨酸(Glu)、丝氨酸(Ser)、缬氨酸(Val)、苯丙氨酸(Phe)、脯氨酸(Pro)、苏氨酸(Thr)、赖氨酸(Lys)、酪氨酸(Tyr)、羟脯氨酸(Hyp)、精氨酸(Arg)、亮氨酸(Leu)、色氨酸(Trp)和甘氨酸(Gly)水平均升高(P <0.001, P <0.05)， Gln和Tau水平降低(P <0.001, P <0.05)。与MCAO组比较，MCAO_D组银杏叶提取物在12 h和24 h显著下调了11种氨基酸的水平，尤其是精氨酸、苏氨酸和丝氨酸的水平。结论注射银杏叶提取物通过作用于大脑皮层的氨基酸对MCAO诱导的脑缺血模型大鼠有治疗作用。这种作用可能与调节大脑皮层的氨基酸代谢有关。
{"title":"Effect of Ginkgo biloba leaf extract on cerebral cortex amino acid levels in cerebral ischemia model rats","authors":"Cui Yiran , Wu Hongwei , Liu Mengting , Qin Haijiao , Liu Xin , Yang Hongjun","doi":"10.1016/S0254-6272(18)30906-3","DOIUrl":"10.1016/S0254-6272(18)30906-3","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the effect of Ginkgo biloba leaf extract on amino acid levels in the cerebral cortex of cerebral ischemia model rats induced by middle cerebral artery occlusion (MCAO).</p></div><div><h3>METHODS</h3><p>A rat model of cerebral ischemia was established by MCAO. Male rats were divided into a negative control group (Control), a sham-operated group (Sham), an ischemic group (MCAO), and an ischemic group treated with Ginkgo biloba leaf extract (MCAO_D). All groups were divided into two subgroups with occlusion times of 12 and 24 h, respectively. The levels of 18 endogenous amino acids in the cerebral cortex were quantified by triple quadrupole-liquid chromatography-mass spectrometry.</p></div><div><h3>RESULTS</h3><p>Compared with the MCAO group, behavioral performance, neurological deficit score, and cerebral infarct volume were significantly improved in the MCAO_D group (<em>P</em> < 0.05, <em>P</em> < 0.01). Compared with the sham group, the levels of 17 amino acids in the cerebral cortex were markedly changed in the MCAO group. The levels of Alanine (Ala), Isoleucine (Ile), Glutamic acid (Glu), Serine (Ser), Valine (Val), Phenylalanine (Phe), Proline (Pro), Threonine (Thr), Lysine (Lys), Tyrosine (Tyr), Hydroxyproline (Hyp), Arginine (Arg), Leucine (Leu), Tryptophan (Trp), and Glycine (Gly) were increased (<em>P</em> < 0.001, <em>P</em> < 0.05), while levels of Gln and Tau were decreased (<em>P</em> < 0.001, <em>P</em> < 0.05). Compared with the MCAO group, Ginkgo biloba extract treatment in the MCAO_D group significantly down-regulated the levels of 11 amino acids, especially those of Arg, Thr, and Ser in 12 or 24 h.</p></div><div><h3>CONCLUSION</h3><p>Injection of Ginkgo biloba leaf extract has a therapeutic effect on model rats with MCAO-induced cerebral ischemia by acting on amino acids in the cerebral cortex. This effect might be associated with the regulation of amino acid metabolism in the cerebral cortex.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30906-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41620552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30907-5
Yu Li , Wan Haofang , Jin Weifeng , Yang Jiehong , Li Chang , Dai Liuling , Ge Lijun , Zhou Huifen , Wan Haitong , He Yu
OBJECTIVE
To investigate the effective ingredients of Danshen (Radix Salviae Miltiorrhizae) and Honghua (Flos Carthami) (Danhong) on protective properties towards neonatal rat hippocampal neurons under hypoxia condition.
METHODS
Primary culture of neonatal rat hippocampal neurons was used to model hypoxia damage on the hippocampus. Methyl thiazolyl tetrazolium (MTT) assay and preliminary experiments were conducted to identify the four effective ingredients of Danhong, along with the injection of positive drug onto hippocampal neurons at a non-toxic dosage level. The cultured cells were randomly divided into 12 groups: the normal group, model group, positive drug control group and nine compatibility groups of the four effective ingredients. Different test methods were applied to determine lactate dehydrogenasein (LDH), total superoxide dismutase (T-SOD), malondialdehyde (MDA), 6-keto prostaglandin Fla (6-keto-PGF1a), thromboxane B2 (TXB2), mitochondrial membrane potential (MMP), free calcium ions concentration ([Ca2+]i) and early onset cell apoptosis.
RESULTS
Different compatibility groups could inhibit the content of LDH and intracellular calcium overload, increase activity in T-SOD, decrease level of MDA and TXB2, improve level of 6-keto-PGF1a and MMP, and prevent the early onset cell apoptosis.
CONCLUSION
The compatibility of four effective ingredients of Danhong had protective effect toward hippocampi hypoxia. The mechanism might be related to inhibit oxidative stress damage and cell apoptosis, resist thrombosis, and reduce the intracellular calcium ion of overload.
{"title":"Protective effects of effective ingredients of Danshen (Radix Salviae Miltiorrhizae) and Honghua (Flos Carthami) compatibility after rat hippocampal neurons induced by hypoxia injury","authors":"Yu Li , Wan Haofang , Jin Weifeng , Yang Jiehong , Li Chang , Dai Liuling , Ge Lijun , Zhou Huifen , Wan Haitong , He Yu","doi":"10.1016/S0254-6272(18)30907-5","DOIUrl":"10.1016/S0254-6272(18)30907-5","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the effective ingredients of Danshen (<em>Radix Salviae Miltiorrhizae</em>) and Honghua (<em>Flos Carthami</em>) (Danhong) on protective properties towards neonatal rat hippocampal neurons under hypoxia condition.</p></div><div><h3>METHODS</h3><p>Primary culture of neonatal rat hippocampal neurons was used to model hypoxia damage on the hippocampus. Methyl thiazolyl tetrazolium (MTT) assay and preliminary experiments were conducted to identify the four effective ingredients of Danhong, along with the injection of positive drug onto hippocampal neurons at a non-toxic dosage level. The cultured cells were randomly divided into 12 groups: the normal group, model group, positive drug control group and nine compatibility groups of the four effective ingredients. Different test methods were applied to determine lactate dehydrogenasein (LDH), total superoxide dismutase (T-SOD), malondialdehyde (MDA), 6-keto prostaglandin F<sub>la</sub> (6-keto-PGF<sub>1a</sub>), thromboxane B<sub>2</sub> (TXB<sub>2</sub>), mitochondrial membrane potential (MMP), free calcium ions concentration ([Ca<sup>2+</sup>]i) and early onset cell apoptosis.</p></div><div><h3>RESULTS</h3><p>Different compatibility groups could inhibit the content of LDH and intracellular calcium overload, increase activity in T-SOD, decrease level of MDA and TXB<sub>2</sub>, improve level of 6-keto-PGF<sub>1a</sub> and MMP, and prevent the early onset cell apoptosis.</p></div><div><h3>CONCLUSION</h3><p>The compatibility of four effective ingredients of Danhong had protective effect toward hippocampi hypoxia. The mechanism might be related to inhibit oxidative stress damage and cell apoptosis, resist thrombosis, and reduce the intracellular calcium ion of overload.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30907-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91448411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30913-0
Sun Wen , Han Xinghui , Wang Yonghong , Yu Jian , Yan Weili , Zhao Jun , Chen Weibin , Xue Zheng
OBJECTIVE
To evaluate the effect of ZiYin Xiehuo granules (ZYXH) and Zishen Qinggan granules (ZSQG) on partial precocious puberty (PPP).
METHODS
This was a multicenter, randomized, single-blind, positive-controlled trial. A total of 143 patients were assigned to either the ZYXH group or the ZSQG group using a random number table. The ZYXH group received ZYXH three times daily for 6 months and the ZSQG group received ZSQG three times daily for 6 months. Mammary nucleus diameter; the results of uterus, ovarian, and maximum follicle measures; and Chinese medicine symptom pattern scores were compared at baseline and after 3 months and 6 months of treatment.
RESULTS
After 3 months’ treatment, there were no significant differences between the two groups in mammary nucleus index changes (left 3.4 ± 3.1 vs 3.5 ± 3.1, P = 0.790; right 3.0 ± 2.9 vs 3.6 ± 3.0, P = 0.719). The uterine volume in the ZYXH group was smaller than that in the ZSQG group (2.1 ± 1.6 vs 2.6 ± 2.2, P = 0.006). There were no significant between-group differences in ovarian volume and maximum follicular diameter on either side (ovarian volume: left 1.2 ± 0.7 vs 1.3 ± 0.6, P = 0.8; right 1.2 ± 0.7 vs 1.4 ± 1.1, P = 0.984; maximum follicular diameter: left 3.9 ± 1.7 vs 3.5 ± 2.2, P = 0.158; right 3.5 ± 1.7 vs 3.9 ± 2.1, P = 0.314).
CONCLUSION
ZYXH granules and ZSQG granules both affected the size of the mammary nucleus in girls with PPP, and improved Chinese medicine symptom patterns. ZYXH granules showed slight advantages over ZSQG granules in terms of the decrease in the size of the uterus, ovaries, and ovarian follicles.
目的评价紫饮泻活颗粒(ZYXH)与紫肾清肝颗粒(ZSQG)治疗部分性性早熟(PPP)的疗效。方法多中心、随机、单盲、正对照试验。使用随机数字表将143例患者分配到ZYXH组或ZSQG组。ZYXH组给予ZYXH每日3次，连续6个月;ZSQG组给予ZSQG每日3次，连续6个月。乳核直径;子宫、卵巢和最大卵泡测量结果;比较两组患者治疗3个月、6个月时的中医症状分型评分。结果治疗3个月后，两组乳腺核指数变化差异无统计学意义(左3.4±3.1 vs 3.5±3.1,P = 0.790;右侧3.0±2.9 vs 3.6±3.0,P = 0.719)。ZYXH组子宫体积小于ZSQG组(2.1±1.6 vs 2.6±2.2,P = 0.006)。双侧卵巢体积和最大卵泡直径组间差异无统计学意义(左侧卵巢体积:1.2±0.7 vs 1.3±0.6,P = 0.8;右侧1.2±0.7 vs 1.4±1.1,P = 0.984;最大卵泡直径:左侧3.9±1.7 vs 3.5±2.2,P = 0.158;右3.5±1.7 vs 3.9±2.1,P = 0.314)。结论zyxh颗粒和ZSQG颗粒均能影响PPP女孩乳腺核的大小，改善其中医证型。ZYXH颗粒在子宫、卵巢和卵泡大小的减小方面比ZSQG颗粒略有优势。
{"title":"Effectiveness of ZiYin Xiehuo granules and Zishen Qinggan granules on partial precocious puberty in girls: a multicenter, randomized, single-blind, controlled trial","authors":"Sun Wen , Han Xinghui , Wang Yonghong , Yu Jian , Yan Weili , Zhao Jun , Chen Weibin , Xue Zheng","doi":"10.1016/S0254-6272(18)30913-0","DOIUrl":"10.1016/S0254-6272(18)30913-0","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To evaluate the effect of ZiYin Xiehuo granules (ZYXH) and Zishen Qinggan granules (ZSQG) on partial precocious puberty (PPP).</p></div><div><h3>METHODS</h3><p>This was a multicenter, randomized, single-blind, positive-controlled trial. A total of 143 patients were assigned to either the ZYXH group or the ZSQG group using a random number table. The ZYXH group received ZYXH three times daily for 6 months and the ZSQG group received ZSQG three times daily for 6 months. Mammary nucleus diameter; the results of uterus, ovarian, and maximum follicle measures; and Chinese medicine symptom pattern scores were compared at baseline and after 3 months and 6 months of treatment.</p></div><div><h3>RESULTS</h3><p>After 3 months’ treatment, there were no significant differences between the two groups in mammary nucleus index changes (left 3.4 ± 3.1 <em>vs</em> 3.5 ± 3.1, <em>P</em> = 0.790; right 3.0 ± 2.9 <em>vs</em> 3.6 ± 3.0, <em>P</em> = 0.719). The uterine volume in the ZYXH group was smaller than that in the ZSQG group (2.1 ± 1.6 <em>vs</em> 2.6 ± 2.2, <em>P</em> = 0.006). There were no significant between-group differences in ovarian volume and maximum follicular diameter on either side (ovarian volume: left 1.2 ± 0.7 <em>vs</em> 1.3 ± 0.6, <em>P</em> = 0.8; right 1.2 ± 0.7 <em>vs</em> 1.4 ± 1.1, <em>P</em> = 0.984; maximum follicular diameter: left 3.9 ± 1.7 <em>vs</em> 3.5 ± 2.2, <em>P</em> = 0.158; right 3.5 ± 1.7 <em>vs</em> 3.9 ± 2.1, <em>P</em> = 0.314).</p></div><div><h3>CONCLUSION</h3><p>ZYXH granules and ZSQG granules both affected the size of the mammary nucleus in girls with PPP, and improved Chinese medicine symptom patterns. ZYXH granules showed slight advantages over ZSQG granules in terms of the decrease in the size of the uterus, ovaries, and ovarian follicles.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30913-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49601723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30914-2
Wu Zhisong , Li Guodong , Wei Wan , Liu Zhaoheng , Wang Wei , Ma Ruihong , Liu Wenhong , Ma Jiaju , Wang Yuguang , Jiao Yang
OBJECTIVE
To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing, the mixture prepared with Chinese medicines follows the treatment regimen of releasing exterior cold and clearing interior heat.
METHODS
Total 330 patients with seasonal influenza were enrolled and randomly and averagely divided into the Chinese herbal medicine, the western medicine and the Chinese patent medicine group. They were treated with Chinese medicine Oseltamivir Phosphate Capsules and the Scattering Wind and Resolving Toxins Capsules. The main efficacy indicators were the antifebrile onset time and recovery time of body temperature. The efficacy and safety of the mixture was scientifically evaluated. Comparisons of several variables were analyzed.
RESULTS
Median antifebrile onset time of the Chinese herbal medicine group was significantly shorter than the western medicine group (P < 0.05) and the Chinese patent medicine group (P < 0.05). The median antifebrile recovery time of the Chinese herbal medicine group was significantly shorter than the Chinese patent medicine group (P < 0.05). The groups evaluated by TCM symptom pattern effect, both the Chinese herbal medicine group and Western Medicine group were better than the Chinese patent medicine group (P < 0.05). The disappearance rate of main symptoms and some minor symptom patterns of the Chinese herbal medicine group were higher than the other 2 groups.
CONCLUSION
The mixture of releasing exterior cold and clearing interior heat could significantly shorten the fever time with safety.
{"title":"Mixture prepared with Chinese medicines in terms of releasing exterior cold and clearing interior heat: its efficacy and safety in patients with seasonal influenza-a randomized controlled trial","authors":"Wu Zhisong , Li Guodong , Wei Wan , Liu Zhaoheng , Wang Wei , Ma Ruihong , Liu Wenhong , Ma Jiaju , Wang Yuguang , Jiao Yang","doi":"10.1016/S0254-6272(18)30914-2","DOIUrl":"10.1016/S0254-6272(18)30914-2","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing, the mixture prepared with Chinese medicines follows the treatment regimen of releasing exterior cold and clearing interior heat.</p></div><div><h3>METHODS</h3><p>Total 330 patients with seasonal influenza were enrolled and randomly and averagely divided into the Chinese herbal medicine, the western medicine and the Chinese patent medicine group. They were treated with Chinese medicine Oseltamivir Phosphate Capsules and the Scattering Wind and Resolving Toxins Capsules. The main efficacy indicators were the antifebrile onset time and recovery time of body temperature. The efficacy and safety of the mixture was scientifically evaluated. Comparisons of several variables were analyzed.</p></div><div><h3>RESULTS</h3><p>Median antifebrile onset time of the Chinese herbal medicine group was significantly shorter than the western medicine group (<em>P</em> < 0.05) and the Chinese patent medicine group (<em>P</em> < 0.05). The median antifebrile recovery time of the Chinese herbal medicine group was significantly shorter than the Chinese patent medicine group (<em>P</em> < 0.05). The groups evaluated by TCM symptom pattern effect, both the Chinese herbal medicine group and Western Medicine group were better than the Chinese patent medicine group (<em>P</em> < 0.05). The disappearance rate of main symptoms and some minor symptom patterns of the Chinese herbal medicine group were higher than the other 2 groups.</p></div><div><h3>CONCLUSION</h3><p>The mixture of releasing exterior cold and clearing interior heat could significantly shorten the fever time with safety.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30914-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85192569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.1016/S0254-6272(18)30915-4
Chen Yan , Gao Xiyan , Sun Cuiying
OBJECTIVE
To observe the clinical effect of pricking and penetrating moxibustion therapy on refractory insomnia.
METHODS
Totally 60 subjects were randomly divided into treatment group and control group, 30 in each group. The treatment group was treated with pricking and penetrating moxibustion therapy, the control group with penetrating moxibustion therapy, the treatment was given once every day, two groups of patients were treated 20 times, compared the efficacy, pinsburgh sleep quality index (PSQI) and Traditional Chinese Medicine symptom, safety evaluation between the two groups.
RESULTS
Compared with 10, 20 times after the treatment, the effective rate of the treatment group (93.3%) higher than that of the control group (80.0%) (P < 0.05); Compared with before treatment, 20 times after treatment, the PSQI and TCM symptom pattern scores of the two groups were significantly decreased (P < 0.01); Compared with 10, 20 times after the treatment, the treatment group are better than the control group in improving the total score and the integral of PSQI (P < 0.05 or P < 0.01); The treatment group are better than the control group in improving the TCM symptom pattern score, difficulty in going to sleep, palpitation, amnesia, fidget, sweating, impaired concentration (P < 0.01 or P < 0.05).
CONCLUSION
The pricking and penetrating moxibustion therapy is safe and effective in the treatment of refractory insomnia and the treatment can improve the curative effect of the therapy that uses penetrating moxibustion only.
{"title":"Pricking and penetrating moxibustion therapy in patients with refractory insomnia: a randomized and controlled clinical trial","authors":"Chen Yan , Gao Xiyan , Sun Cuiying","doi":"10.1016/S0254-6272(18)30915-4","DOIUrl":"10.1016/S0254-6272(18)30915-4","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To observe the clinical effect of pricking and penetrating moxibustion therapy on refractory insomnia.</p></div><div><h3>METHODS</h3><p>Totally 60 subjects were randomly divided into treatment group and control group, 30 in each group. The treatment group was treated with pricking and penetrating moxibustion therapy, the control group with penetrating moxibustion therapy, the treatment was given once every day, two groups of patients were treated 20 times, compared the efficacy, pinsburgh sleep quality index (PSQI) and Traditional Chinese Medicine symptom, safety evaluation between the two groups.</p></div><div><h3>RESULTS</h3><p>Compared with 10, 20 times after the treatment, the effective rate of the treatment group (93.3%) higher than that of the control group (80.0%) (<em>P</em> < 0.05); Compared with before treatment, 20 times after treatment, the PSQI and TCM symptom pattern scores of the two groups were significantly decreased (<em>P</em> < 0.01); Compared with 10, 20 times after the treatment, the treatment group are better than the control group in improving the total score and the integral of PSQI (<em>P</em> < 0.05 or <em>P</em> < 0.01); The treatment group are better than the control group in improving the TCM symptom pattern score, difficulty in going to sleep, palpitation, amnesia, fidget, sweating, impaired concentration (<em>P</em> < 0.01 or <em>P</em> < 0.05).</p></div><div><h3>CONCLUSION</h3><p>The pricking and penetrating moxibustion therapy is safe and effective in the treatment of refractory insomnia and the treatment can improve the curative effect of the therapy that uses penetrating moxibustion only.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30915-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45732269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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