Journal of Traditional Chinese Medicine最新文献_第4页

Mixture prepared with Chinese medicines in terms of releasing exterior cold and clearing interior heat: its efficacy and safety in patients with seasonal influenza-a randomized controlled trial 中药复方外冷清热对季节性流感患者的疗效及安全性——随机对照试验

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-10-01 Epub Date: 2018-11-30 DOI: 10.1016/S0254-6272(18)30914-2

Wu Zhisong , Li Guodong , Wei Wan , Liu Zhaoheng , Wang Wei , Ma Ruihong , Liu Wenhong , Ma Jiaju , Wang Yuguang , Jiao Yang

OBJECTIVE

To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing, the mixture prepared with Chinese medicines follows the treatment regimen of releasing exterior cold and clearing interior heat.

METHODS

Total 330 patients with seasonal influenza were enrolled and randomly and averagely divided into the Chinese herbal medicine, the western medicine and the Chinese patent medicine group. They were treated with Chinese medicine Oseltamivir Phosphate Capsules and the Scattering Wind and Resolving Toxins Capsules. The main efficacy indicators were the antifebrile onset time and recovery time of body temperature. The efficacy and safety of the mixture was scientifically evaluated. Comparisons of several variables were analyzed.

RESULTS

Median antifebrile onset time of the Chinese herbal medicine group was significantly shorter than the western medicine group (P < 0.05) and the Chinese patent medicine group (P < 0.05). The median antifebrile recovery time of the Chinese herbal medicine group was significantly shorter than the Chinese patent medicine group (P < 0.05). The groups evaluated by TCM symptom pattern effect, both the Chinese herbal medicine group and Western Medicine group were better than the Chinese patent medicine group (P < 0.05). The disappearance rate of main symptoms and some minor symptom patterns of the Chinese herbal medicine group were higher than the other 2 groups.

CONCLUSION

The mixture of releasing exterior cold and clearing interior heat could significantly shorten the fever time with safety.

目的观察中药配伍治疗北京地区105例季节性流感患者的疗效和安全性，治疗方案为外寒清热。方法将330例季节性流感患者随机平均分为中草药组、西药组和中成药组。采用中药磷酸奥司他韦胶囊和散风解毒胶囊治疗。主要疗效指标为退热起效时间和体温恢复时间。科学评价了合剂的有效性和安全性。对几个变量进行了比较分析。结果中草药组抗热起效时间中位数显著短于西药组(P <0.05)，中成药组(P <0.05)。中草药组的中位解热恢复时间显著短于中成药组(P <0.05)。以中医证型疗效评价各组，中草药组和西药组均优于中成药组(P <0.05)。中草药治疗组的主要症状及部分次要症状消失率均高于其他两组。结论外冷清热混合使用能明显缩短发热时间，且安全。

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引用次数: 2

Pricking and penetrating moxibustion therapy in patients with refractory insomnia: a randomized and controlled clinical trial 刺穿灸治疗难治性失眠:一项随机对照临床试验

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-10-01 Epub Date: 2018-11-30 DOI: 10.1016/S0254-6272(18)30915-4

Chen Yan , Gao Xiyan , Sun Cuiying

OBJECTIVE

To observe the clinical effect of pricking and penetrating moxibustion therapy on refractory insomnia.

METHODS

Totally 60 subjects were randomly divided into treatment group and control group, 30 in each group. The treatment group was treated with pricking and penetrating moxibustion therapy, the control group with penetrating moxibustion therapy, the treatment was given once every day, two groups of patients were treated 20 times, compared the efficacy, pinsburgh sleep quality index (PSQI) and Traditional Chinese Medicine symptom, safety evaluation between the two groups.

RESULTS

Compared with 10, 20 times after the treatment, the effective rate of the treatment group (93.3%) higher than that of the control group (80.0%) (P < 0.05); Compared with before treatment, 20 times after treatment, the PSQI and TCM symptom pattern scores of the two groups were significantly decreased (P < 0.01); Compared with 10, 20 times after the treatment, the treatment group are better than the control group in improving the total score and the integral of PSQI (P < 0.05 or P < 0.01); The treatment group are better than the control group in improving the TCM symptom pattern score, difficulty in going to sleep, palpitation, amnesia, fidget, sweating, impaired concentration (P < 0.01 or P < 0.05).

CONCLUSION

The pricking and penetrating moxibustion therapy is safe and effective in the treatment of refractory insomnia and the treatment can improve the curative effect of the therapy that uses penetrating moxibustion only.

目的观察刺穿灸法治疗难治性失眠的临床疗效。方法将60例患者随机分为治疗组和对照组，每组30例。治疗组采用刺穿灸法治疗，对照组采用刺穿灸法治疗，每天给予1次治疗，两组患者共治疗20次，比较两组患者的疗效、睡眠质量指数(PSQI)及中医症状、安全性评价。结果与治疗后10、20次相比，治疗组有效率(93.3%)高于对照组(80.0%)(P <0.05);与治疗前、治疗后20倍比较，两组患者PSQI及中医证候分均显著降低(P <0.01);与治疗后10、20次比较，治疗组在改善总评分和PSQI积分(P <0.05或P <0.01);治疗组在改善中医证型评分、入睡困难、心悸、健忘、坐立不安、多汗、注意力不集中等方面均优于对照组(P <0.01或P <0.05)。结论刺穿灸法治疗难治性失眠安全有效，可提高单纯刺穿灸法的疗效。

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引用次数: 2

Ethyl acetate fraction in ethanol extract from root of “Dai-Bai-Jie” (Marsdenia tenacissima): anti-tumor activity in A549 cancer cells 大白节根乙醇提取物乙酸乙酯部分:对A549癌细胞的抗肿瘤活性

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-10-01 Epub Date: 2018-11-30 DOI: 10.1016/S0254-6272(18)30905-1

Li Xiaohua , Li Haitao , Jin Lingyu , Chen Leixi , Niu Yingfeng , Guan Yanhong , Ma Xiaojun , Zhang Lixia

OBJECTIVE

To evaluate the anti-tumor activity of ethyl acetate fraction (EFA), extracted with ethanol from the root of “Dai-Bai-Jie” in A549 cancer cells and its underlying mechanism.

METHODS

“Dai-Bai-Jie” was extracted with 95% ethanol-aqueous (DBJ-1), 50% ethanol-aqueous (DBJ-2), and water (DBJ-3) by reflux method. 95% ethanol-aqueous extract was separated byethyl acetate (EFA) and n-butyl alcohol (DBJ-5), consecutively. The SRB method was used to evaluate the cytotoxic activity. Annexin V-FITC staining was applied to observe the apoptosis and analyze the cell cycle activated by EFA in A549 tumor cell. Western blot was used to detect the apoptosis/related proteins expressions. A549 tumor cellsbearing nude mice model was employed to measure the tumor volume, mice weight, and tumor inhibition ratio in order to verify the antitumor activity in vivo.

RESULTS

DBJ-1 and EFA showed better cytotoxic activity on A549 tumor cells with IC₅₀ 25 and 3.5 µg/mL, respectively. EFA can exhibit the proliferation, arrest cell cycle at G0/G1 phase, and induce apoptosis in A549 tumor cells in vitro. The mechanisms of apoptosis induced by EFA may be associated with decreasing Bcl-2 protein expression and increasing p53, Bax, Caspase-3, and Caspase-8 proteins expression. EFA also possessed significant anti-tumor efficacy in nude mice, and little toxicity was observed in the host.

CONCLUSION

EAF could induce A549 tumor cells apoptosis and G0/G1 cell cycle arrest. A549 tumor cells apoptosis induced by EAF may be associated with the decrease in the ratio of Bcl-2 and Bax mRNA levels, and increase in the expression of p53, Caspase-3, and Caspase-8 proteins.

目的研究代白节根乙醇提取乙酸乙酯部位对A549肿瘤细胞的抗肿瘤作用及其机制。方法以95%乙醇水溶液(DBJ-1)、50%乙醇水溶液(DBJ-2)、水(DBJ-3)为萃取剂，采用回流法提取“代白节”。用乙酸乙酯(EFA)和正丁醇(DBJ-5)分别对95%乙醇-水提物进行分离。采用SRB法评价其细胞毒活性。采用Annexin V-FITC染色法观察A549肿瘤细胞凋亡情况，分析EFA激活的细胞周期。Western blot检测细胞凋亡/相关蛋白的表达。采用携带A549肿瘤细胞的裸鼠模型，测定肿瘤体积、小鼠体重和肿瘤抑制率，验证其体内抗肿瘤活性。结果dbj -1和EFA对A549肿瘤细胞具有较好的细胞毒活性，IC50分别为25和3.5µg/mL。EFA能在体外诱导A549肿瘤细胞增殖，使细胞周期停留在G0/G1期，并诱导细胞凋亡。EFA诱导细胞凋亡的机制可能与降低Bcl-2蛋白表达，增加p53、Bax、Caspase-3、Caspase-8蛋白表达有关。EFA对裸鼠也有明显的抗肿瘤作用，对宿主的毒性很小。结论eaf可诱导A549肿瘤细胞凋亡，阻滞G0/G1细胞周期。EAF诱导A549肿瘤细胞凋亡可能与Bcl-2和Bax mRNA水平比值降低，p53、Caspase-3和Caspase-8蛋白表达升高有关。

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引用次数: 1

Evaluation of efficacy and safety of gandouling plus sodium dimercaptosulphonate in treatment of patients with neurological Wilson's disease from China 甘多灵联合二巯基磺酸钠治疗中国神经性威尔逊氏病的疗效和安全性评价

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-10-01 Epub Date: 2018-11-30 DOI: 10.1016/S0254-6272(18)30919-1

Zhang Jing , Xie Daojun , Guo Yanbing , Li Yajun , Li Liangyong , Han Hui , Zhang Juan , Chen Huaizhen , Wang Meixia

OBJECTIVE

To evaluate the efficacy and safety of gandouling plus sodium dimercaptosulphonate (DMPS) on neurological Wilson's disease (WD) in patients.

METHODS

We retrospectively evaluated the clinical records of 125 WD patients with neurological syndromes who were treated with gandouling plus sodium DMPS or DMPS used alone. All patients had a history of neurological deterioration during their diseases courses. The clinical efficacies, adverse reactions, and results of the various hematological and biochemical investigations were recorded for statistical analysis.

RESULTS

92.30% (60 patients) of the WD patients treated with the combined therapy experienced an improved or stable neurological condition paralleled by a significantly improved GAS score. Meanwhile, the WBC and PLT counts stabilized, liver function and renal function were improved or remained stable. The combined therapy also obviously promoted the 24-h urinary copper excretion. In particular, only 30.76% of the WD patients experienced mild adverse reactions, including neurological deterioration in 5 patients (7.69%), hepatic worsening in 1 subject (1.89%), which was less frequently than those in the control group treated with DMPS only.

CONCLUSION

Our findings indicate that the safety and efficacy of gandou-ling plus DMPS is superior to those of DMPS used alone in the WD patients with neurological symptoms.

目的评价甘多灵联合二巯基磺酸钠(DMPS)治疗神经性威尔逊病(WD)的疗效和安全性。方法回顾性分析125例合并神经系统综合征的WD患者的临床资料，这些患者分别使用甘多灵联合DMPS钠或单独使用DMPS钠。所有患者在病程中均有神经功能恶化史。结果92.30%(60例)WD患者经联合治疗后神经系统状况改善或稳定，GAS评分显著提高。同时WBC和PLT计数稳定，肝功能和肾功能改善或保持稳定。联合用药对24小时尿铜排泄也有明显促进作用。其中，仅30.76%的WD患者出现轻度不良反应，其中神经系统恶化5例(7.69%)，肝脏恶化1例(1.89%)，发生率低于仅接受DMPS治疗的对照组。结论肝毒灵联合DMPS治疗伴有神经系统症状的WD患者的安全性和有效性优于单用DMPS。

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引用次数: 6

Toxicity study of ethanol extract from Oroxylumindicum (L.) Vent in rats 乙醇提取物的毒性研究大鼠排气

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-10-01 Epub Date: 2018-11-30 DOI: 10.1016/S0254-6272(18)30910-5

Yi Yan , Zhao Yong , Li Chunying , Zhang Yushi , Bin Yang , Yuan Yalan , Wang Lianmei , Pan Chen , Liang Aihua

OBJECTIVE

To evaluate the safety of Oroxylumindicum(L.) Vent extract administered for 26 weeks in Wistar rats.

METHODS

Oroxylumindicum (L.) Vent extract was administrated to male and female rats by gavage once daily at doses of 54, 225, and450 mg • kg⁻¹ • d⁻¹. The rats were sacrificed after administration for13 weeks and 26 weeks. Part of the rats in each group were allowed to recover for 4 weeks after 26-week administration. Systematic examinations including haematology, urology, blood biochemistry and histomorphology were performed at the end of 13, 26 weeks of administration and 4 weeks of recovery.

RESULTS

No treatment related adverse effect shappened on rats'general status, body weight, food consumption, urinary index and histomorphology examination. Although during the administration, in some rats of extract's groups, the value of Red blood cell count (RBC), white blood cell counts (WBC), hemoglobin (HGB), haematocrit (HCT) and K iron were decreased, and biochemistry index, such as glucose (GLU), triglyceride (TG), alanine transaminase (ALT) and blood urea nitrogen(BUN) were increased, the above parameters were within the normal ranges and all returned to baseline after the drug stopping for 4 weeks.

CONCLUSION

The administration of Oroxylumindicum(L.) Vent extractat levers up to 450 mg/kg (equals to 75 times of clinical dose) is well tolerated-for both genders without significant toxicity within the administration duration in this study.

目的评价欧氧苄氨苄的安全性。Wistar大鼠连续用药26周。METHODSOroxylumindicum (l)分别以54、225和450 mg•kg•d - 1的剂量灌胃给雄性和雌性大鼠，每天1次。给药13周和26周后处死大鼠。给药26周后，各组均有部分大鼠恢复4周。分别于给药13周、26周和康复4周时进行血液学、泌尿学、血液生化和组织形态学等系统检查。结果对大鼠一般状态、体重、食量、尿指数及组织形态学检查均无不良反应。虽然在给药过程中，部分提取物组大鼠红细胞计数(RBC)、白细胞计数(WBC)、血红蛋白(HGB)、红细胞压差(HCT)、血钾铁(K - iron)下降，葡萄糖(GLU)、甘油三酯(TG)、丙氨酸转氨酶(ALT)、血尿素氮(BUN)等生化指标升高，但上述指标均在正常范围内，停药4周后均恢复到基线水平。结论:复方白藜芦醇(L.)在本研究中，高达450 mg/kg(相当于临床剂量的75倍)的排气提取物杠杆对两性都有良好的耐受性，在给药期间没有明显的毒性。

{"title":"Toxicity study of ethanol extract from Oroxylumindicum (L.) Vent in rats","authors":"Yi Yan , Zhao Yong , Li Chunying , Zhang Yushi , Bin Yang , Yuan Yalan , Wang Lianmei , Pan Chen , Liang Aihua","doi":"10.1016/S0254-6272(18)30910-5","DOIUrl":"10.1016/S0254-6272(18)30910-5","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To evaluate the safety of Oroxylumindicum(L.) Vent extract administered for 26 weeks in Wistar rats.</p></div><div><h3>METHODS</h3><p>Oroxylumindicum (L.) Vent extract was administrated to male and female rats by gavage once daily at doses of 54, 225, and450 mg • kg<sup>−1</sup> • d<sup>−1</sup>. The rats were sacrificed after administration for13 weeks and 26 weeks. Part of the rats in each group were allowed to recover for 4 weeks after 26-week administration. Systematic examinations including haematology, urology, blood biochemistry and histomorphology were performed at the end of 13, 26 weeks of administration and 4 weeks of recovery.</p></div><div><h3>RESULTS</h3><p>No treatment related adverse effect shappened on rats'general status, body weight, food consumption, urinary index and histomorphology examination. Although during the administration, in some rats of extract's groups, the value of Red blood cell count (RBC), white blood cell counts (WBC), hemoglobin (HGB), haematocrit (HCT) and K iron were decreased, and biochemistry index, such as glucose (GLU), triglyceride (TG), alanine transaminase (ALT) and blood urea nitrogen(BUN) were increased, the above parameters were within the normal ranges and all returned to baseline after the drug stopping for 4 weeks.</p></div><div><h3>CONCLUSION</h3><p>The administration of Oroxylumindicum(L.) Vent extractat levers up to 450 mg/kg (equals to 75 times of clinical dose) is well tolerated-for both genders without significant toxicity within the administration duration in this study.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 5","pages":"Pages 714-725"},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30910-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87936320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Gua Sha attenuates thermal hyperalgesia and decreases proinflammatory cytokine expression in serum in rats with lumbar disc herniation induced by autologous nucleus pulposus 瓜沙可减轻自体髓核致腰椎间盘突出症大鼠热痛觉过敏，降低血清促炎细胞因子表达

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-10-01 Epub Date: 2018-11-30 DOI: 10.1016/S0254-6272(18)30908-7

Yang Min , Zhang Hongyan , Yue Rongzhao , Shi Qinchuan , Bian Yaoyao

OBJECTIVE

To investigate the analgesic effect of Gua Sha and its underlying mechanism in rats with noncompressive lumbar disk herniation induced by autologous nucleus pulposus.

METHODS

A rat model of noncompressive lumbar disk herniation was established and rats were randomly divided into model group, sham group, and Gua Sha group (24 in each group). Gua Sha was performed from the 5th day after the surgery, once every other day, 3 times for a course of treatment, and totally 3 courses. The thermal withdrawal latency was evaluated using the intelligent hot plate one day before the surgery, and on days 4 (the day before the treatment), 10 (the end of the first course), 16 (the end of the second course) and 22 (the end of the third course). On days 4, 10, 16 and 22, six rats in each group were picked randomly and their blood samples were drawn to assess the expression of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α).

RESULTS

Compared to rats in the sham group, the application of nucleus pulposus to right L5 dorsal root ganglion induced prolonged thermal hyperalgesia, and up-regulated the expression of IL-1β, IL-6 and TNF-α in serum (P < 0.01). The therapy of Gua Sha attenuated thermal hyperalgesia potently, inhibited the expression of IL-1β, IL-6 and TNF-α in a time-dependent manner (P < 0.01). There were no significant differences in the thermal withdrawal latency and the expression of inflammatory cytokines between the sham and Gua Sha groups at the end of the treatment (P > 0.01).

CONCLUSION

The current study showed that Gua Sha might alleviate thermal hyperalgesia in rats with lumbar disc herniation induced by autologous nucleus pulposus via inhibiting the expression of proinflammatory cytokins.

目的探讨瓜沙对自体髓核所致非压缩性腰椎间盘突出症大鼠的镇痛作用及其机制。方法建立非压缩性腰椎间盘突出症大鼠模型，将大鼠随机分为模型组、假手术组和瓜沙组，每组24只。术后第5天起进行瓜沙治疗，每隔一天1次，3次为1个疗程，共3个疗程。术前1天、第4天(治疗前一天)、第10天(第一个疗程结束)、第16天(第二个疗程结束)、第22天(第三个疗程结束)采用智能热板评估热戒断潜伏期。在第4、10、16、22天，每组随机抽取6只大鼠，取血检测白细胞介素-1β (IL-1β)、白细胞介素-6 (IL-6)和肿瘤坏死因子-α (TNF-α)的表达。结果与假手术组比较，髓核施加于右侧L5背根神经节诱导大鼠长时间热痛觉过敏，血清中IL-1β、IL-6、TNF-α表达上调(P <0.01)。瓜沙治疗能明显减轻热痛觉过敏，并以时间依赖性的方式抑制IL-1β、IL-6和TNF-α的表达(P <0.01)。假药组和瓜沙组治疗结束时热戒断潜伏期和炎症因子表达无显著差异(P >0.01)。结论瓜沙可能通过抑制促炎细胞因子的表达，减轻自体髓核所致大鼠腰椎间盘突出症的热痛觉过敏。

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引用次数: 5

Efficacy and safety of Shaoyang Xibi decoction in patients with knee osteoarthritis: a multi-center, single-blind, randomized controlled trial 少阳喜痹汤治疗膝关节骨性关节炎的疗效和安全性:一项多中心、单盲、随机对照试验

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-10-01 Epub Date: 2018-11-30 DOI: 10.1016/S0254-6272(18)30912-9

Si Yuhao , Ma Yong , Guo Yang , Pan Yalan , Zheng Suyang , Xu Guihua , Da Weiwei , Xu Lili

PURPOSE

To observe the efficacy and safety of Shaoyang Xibi decoction (SYXBD) in patients with knee osteoarthritis (KOA), and to verify that the theory of “Shaoyang dominating bone” in Traditional Chinese Medicine (TCM) can be applied to KOA treatment.

METHODS

Participants were randomly allocated to two groups: SYXBD (treatment group, n = 66) and Meloxicam (control group, n = 66). Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and 36-Item Short Form Health Survey (SF-36) were used to assess efficacy before the treatment and 8 weeks after the treatment.

RESULTS

Baseline data before the treatment between the two groups were similar. The WOMAC scores significantly decreased and the SF-36 scores significantly increased after 8- week treatment in both groups compared with before the treatment (P < 0.05). SYXBD significantly decreased pain scores (P < 0.001), physical function scores (P < 0.001) and the total scores (P < 0.001) in WOMAC compared to Meloxicam. SYXBD significantly improved physical function (P = 0.021), bodily pain (P = 0.002) and general health (P = 0.014), with no significant difference in role emotional (P = 0.053), role physical (P = 0.517), vitality (P = 0.241), social function (P = 0.712) and mental health (P = 0.800) in SF-36 compared to Meloxicam. No adverse events were reported in the treatment group while 13 adverse events happened in the control group during the study.

CONCLUSION

SYXBD, prepared based on the theory of “Shaoyang dominating bone”, has a better curative efficay and safety in patients with KOA compared with Meloxicam. The TCM theory of “Shaoyang dominating bone” may be useful in KOA treatment.

目的观察少阳喜痹汤(SYXBD)治疗膝骨性关节炎(KOA)的疗效和安全性，验证中医“少阳为主骨”理论在KOA治疗中的应用。方法随机分为两组:治疗组，n = 66;对照组，n = 66。采用西安大略和麦克马斯特大学骨关节炎指数(WOMAC)和36项简短健康调查(SF-36)评估治疗前和治疗后8周的疗效。结果两组治疗前基线数据相似。治疗8周后，两组患者的WOMAC评分较治疗前显著降低，SF-36评分较治疗前显著升高(P <0.05)。SYXBD显著降低疼痛评分(P <0.001)，身体功能评分(P <0.001)和总分(P <0.001)，与美洛昔康相比。与美洛昔康相比，SYXBD显著改善SF-36患者的身体功能(P = 0.021)、身体疼痛(P = 0.002)和总体健康(P = 0.014)，但在角色情绪(P = 0.053)、角色身体(P = 0.517)、活力(P = 0.241)、社会功能(P = 0.712)和心理健康(P = 0.800)方面无显著差异。治疗组在研究过程中无不良事件发生，对照组在研究过程中发生13例不良事件。结论以“少阳主骨”理论为基础制备的syxbd治疗KOA的疗效和安全性优于美洛昔康。中医“少阳主骨”理论对KOA的治疗有一定的指导意义。

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引用次数: 8

Effectiveness and safety of auricular acupoint bloodletting in treatment of insomnia: an assessor-blinded pilot randomized controlled trial 耳穴放血治疗失眠症的有效性和安全性:一项评估盲导随机对照试验

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-10-01 Epub Date: 2018-11-30 DOI: 10.1016/S0254-6272(18)30916-6

Ni Jing , Wang Bin , Wang Fuzhuang , Zhou Hongwei , Shi Huaxin , Zhang Ninan , Zhao Hong , Xie Qi

OBJECTIVE

To evaluate the effectiveness and safety of auricular acupoint bloodletting in treatment of insomnia

METHODS

Participants (n = 60) with insomnia were randomized into two groups to receive treatment of auricular acupoint bloodletting: low frequency group, 1 times/week for five weeks (n = 30); high frequency group, 2times/week for two weeks (n = 30). The following outcomes were measured blindly at baseline, after first treatment, 4 weeks, and 8 weeks: Pittsburgh sleep quality index scale (PSQI).

RESULTS

The groups were balanced at baseline for insomnia and demographic characteristics. There were no significant differences between the groups in terms of any of the outcomes, at the first follow-up time point. However, the therapeutic effect of LFG (once per week) is obviously lower than that of HFG (twice per week). In addition, there was no significant difference in the side effects between the two groups.

CONCLUSION

The treatment of insomnia with different frequencies of auricular acupoint bloodletting is effective and has less side effects. More reasonable treatment frequencies are worth further study.

目的评价耳穴放血治疗失眠症的有效性和安全性。方法将60例失眠症患者随机分为两组:低频组，每周1次，连续5周(n = 30);高频组，2次/周，连续2周(n = 30)。在基线、第一次治疗后、第4周和第8周盲测以下结果:匹兹堡睡眠质量指数量表(PSQI)。结果两组在失眠症和人口学特征基线上达到平衡。在第一个随访时间点，两组之间的任何结果都没有显著差异。但LFG(每周一次)的治疗效果明显低于HFG(每周两次)。此外，两组之间的副作用无显著差异。结论不同频率的耳穴放血治疗失眠症疗效确切，副作用少。更合理的治疗频率值得进一步研究。

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引用次数: 4

Tonifying Qi and activating blood circulation in terms of Traditional Chinese Medicine: their effects in patients with myocardial infarction 中医补气活血:对心肌梗死患者的影响

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-10-01 Epub Date: 2018-11-30 DOI: 10.1016/S0254-6272(18)30911-7

Gao Wulin , Dai Guohua , Zhang Tong , Bi Dongxue , Liu Chunhua , Shi Xiaojing , Zhao Fang , Zhao Chen

OBJECTIVE

To investigate the effects of tonifying Qi and activating blood circulation (SQABC), a method in Traditional Chinese Medicine (TCM), on end-point events in patients with myocardial infarction (MI) in this retrospective cohort study.

METHODS

Clinical data were obtained from the medical records of patients with acute MI (AMI), both during hospitalization and follow-up, and included general demographic information (age, gender, and contact information), TCM regimens used, and end-point events.

RESULTS

A total of 1596 patients with AMI were enrolled to this study, but data of only 1210 cases are accessible till follow-up. We classified the patients based on the exposure levels of SQABC. When comparing the results between all exposure and non-exposure groups, significant differences were identified, both during hospitalization and follow-ups. During hospitalization, cardiac death (4.40% vs 21.55%, P < 0.05) and cardiac shock (3.04% vs 11.62%, P < 0.05) were significantly lower in the exposure group than the non-exposure group. Similarly, during the follow-up, cardiac death (12.04% vs 20.49%, P < 0.05), acute heart failure (7.27% vs 11.81%, P < 0.05), composite endpoint of reinfarction and stroke (9.11% vs 15.28%, P < 0.05), and rehospitalization due to angina (25.49% vs 34.38%, P < 0.05) were significantly lower in the exposure group than the non-exposure group.

CONCLUSION

Our findings suggest that SQABC can significantly benefits the subjects in the management of high-risk AMI in them.

目的通过回顾性队列研究，探讨补气活血法(SQABC)对心肌梗死(MI)患者终点事件的影响。方法从急性心肌梗死(AMI)患者住院和随访期间的医疗记录中获取临床资料，包括一般人口学信息(年龄、性别、联系方式)、使用的中医方案和终点事件。结果本研究共纳入1596例AMI患者，但截至随访仅有1210例患者资料可查。我们根据SQABC的暴露水平对患者进行分类。当比较所有暴露组和非暴露组之间的结果时，在住院和随访期间都发现了显著差异。住院期间心源性死亡(4.40% vs 21.55%， P <0.05)和心源性休克(3.04% vs 11.62%， P <0.05)，暴露组显著低于未暴露组。同样，在随访期间，心源性死亡(12.04% vs 20.49%， P <0.05)，急性心力衰竭(7.27% vs 11.81%， P <0.05)，再梗死和卒中的复合终点(9.11% vs 15.28%， P <0.05)，心绞痛再住院(25.49% vs 34.38%， P <0.05)，暴露组显著低于未暴露组。结论SQABC对高危AMI患者的治疗有明显的益处。

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引用次数: 1

Clinical practices s of Traditional Chinese Medicine for acute upper respiratory tract infection in children 中医药治疗小儿急性上呼吸道感染的临床实践。

IF 2.6 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine

Pub Date : 2018-08-01 Epub Date: 2018-11-28 DOI: 10.1016/S0254-6272(18)30882-3

Rong Ping , Li Li , Zhang Xilian , Liu Quanhui , Yan Huimin , Xin Deli , Xue Zheng , Ren Xianqing , Wu Zhenqi , Ma Rong , Zhang Junhua

OBJECTIVE

To develop Clinical practice s of Traditional Chinese Medicine (TCM) for acute upper respiratory tract infection (AURI) in children; TCM is used alone or administered together with antibiotics.

METHODS

Under the guidance of evidence-based medicine concept, in strict accordance with the rules of international s development, as well as on the basis of evidence of clinical research of TCM, the s solicited opinions from clinical experts and methodologists in TCM and Western Medicine. GRADE standard was applied to form experts’ consensus.

RESULTS

The s standardized classification of TCM patterns and TCM treatments in children with AURI, including prescription, Chinese patent medicine, non-drug treatment and prevention.

CONCLUSION

Follows the principle of “evidence based, consensus supplemented, and experience referred”, these s were formulated, but the quality of evidence of included studies were relatively low. Further refinement of the s should be needed as deeper clinical studies as available in future.

目的探讨小儿急性上呼吸道感染(AURI)的中医治疗方法;中药可单独使用或与抗生素联合使用。方法在循证医学理念指导下，严格按照国际医学发展规律，以中医临床研究证据为基础，广泛征求中西医临床专家和方法学家的意见。采用GRADE标准，形成专家共识。结果对小儿急性呼吸道感染的中医辨证论治进行了规范化分类，包括方剂、中成药、非药物治疗和预防。结论遵循“以证据为基础、补充共识、借鉴经验”的原则，制定了这些准则，但纳入研究的证据质量相对较低。随着临床研究的深入，需要进一步完善s。

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引用次数: 1