Journal of Traditional Chinese Medicine最新文献

{"title":"Drug-containing serum of Xinfeng capsules protect against H9C2 from death by enhancing miRNA-21 and inhibiting toll-like receptor 4/phosphorylated p-38 (p-p38)/p-p65 signaling pathway and proinflammatory cytokines expression","authors":"Cao Yunxiang ,&nbsp;Guo Yunke ,&nbsp;Zong Ruikai ,&nbsp;Huang Chuanbing ,&nbsp;Wang Yue ,&nbsp;Liu Jian","doi":"10.1016/S0254-6272(18)30626-5","DOIUrl":"10.1016/S0254-6272(18)30626-5","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate effect of drug-containing serum of Xinfeng capsules on myocardial cell growth.</p></div><div><h3>METHODS</h3><p>Drug-containing serum of Xinfeng capsules rat models were established by intragastricly administrated Xinfeng capsules. MTT assay was used to evaluated H9C2 cells viability. H9C2 cells were divided into normal control group, triptolide group, lipopolysaccharide (LPS) group, drug-containing serum group and miRNA-21 inhibitor group. microRNA-21 (miRNA-21) inhibitor was structured and transfected into H9C2 cells. Western blot and immunofluorescence assay were applied to examine toll-like receptor 4 (TLR4), phosphorylated p-38 (p-p38) and p-p65 expression. Quantitative real-time PCR (qRT-PCR) was used to evaluated mRNA levels of miRNA-21. Enzyme linked immunosorbent (ELISA) was used to measure tumor necrosis factor α (TNF-α), IL-6 and IL-17 levels.</p></div><div><h3>RESULTS</h3><p>Drug-containing serum treatment significantly increased cell viability compared to LPS treated group. qRT-PCR results indicated that miRNA-21 levels were significantly decreased in drug-containing serum group compared to LPS group. Early and late apoptosis in drug-containing serum group were significantly decreased compared to LPS group. Western blot and immunofluorescence assay results showed that TLR4, p-p38 and p-p65 levels in drug-containing serum group were significantly decreased compared to LPS group. ELISA findings indicated that drug-containing serum significantly decreased inflammatory cytokine levels of TNF-α, IL-6 and IL-17.</p></div><div><h3>CONCLUSION</h3><p>Drug-containing serum of Xinfeng capsules protect against lipopolysaccharide instructed H9C2 cells from death by enhancing miRNA-21 and inhibiting TLR4/p-p38/p-p65 signaling pathway and proinflammatory cytokines expression.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 359-365"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30626-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47237526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial, hemagglutination and phytotoxic activity of crude ethanolic and aqueous extracts of Seriphidium kurramense","authors":"Kafeel Ahmad,&nbsp;Amjad Ali,&nbsp;Waqar Ahmed Afridi,&nbsp;Ramla Somayya,&nbsp;Muhammad Jawad Ullah","doi":"10.1016/S0254-6272(18)30635-6","DOIUrl":"10.1016/S0254-6272(18)30635-6","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the antimicrobial activity, hemagglutination and phytotoxic activity of crude ethanolic and aqueous extracts of Seriphidium kurramense.</p></div><div><h3>METHODS</h3><p>The extracts were analyzed by agar well diffusion assays against five bacterial species: Staphylococcus aureus (S. aureus), methicillin-resistant S. aureus, Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, and Salmonella typhi. The extracts were also screened against six fungal species — Aspergillus niger, Aspergillus flavus, Alternaria solani, Rhizoctonia solani, Fusarium solani and Pleurotus florida — using the agar tube diffusion method. Additionally, hemagglutination and phytotoxic activities of the crude ethanolic and aqueous extracts were assessed.</p></div><div><h3>RESULTS</h3><p>The crude ethanolic and aqueous extracts showed dose-dependent inhibition of the various tested fungal and bacterial strains. No hemagglutination activity was observed. Both the ethanolic and aqueous extracts showed dose-dependent phytotoxic activity toward Lemna minor.</p></div><div><h3>CONCLUSION</h3><p>The crude ethanolic and aqueous extracts of Seriphidium kurramense possess good antimicrobial and phytotoxic activities, but no hemagglutination activity.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 433-438"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30635-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42676904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Traditional Chinese Medicine in patients with acute myocardial infarction suffering from diabetes mellitus","authors":"Dai Guohua ,&nbsp;Gao Wulin ,&nbsp;Bi Dongxue ,&nbsp;Liu Chunhua ,&nbsp;Liu Yuhan ,&nbsp;Wang Ning ,&nbsp;Zhao Chen","doi":"10.1016/S0254-6272(18)30632-0","DOIUrl":"10.1016/S0254-6272(18)30632-0","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the “real world” effectiveness of Traditional Chinese Medicine (TCM) in patients with acute myocardial infarction suffering from diabetes mellitus (AMI+DM patients).</p></div><div><h3>METHODS</h3><p>This was a retrospective cohort study. During hospitalization, the “exposure group” was defined as patients who had a TCM injection for ≥ 7 d. During follow-up, the definition of the exposure group was application of a Chinese patent medicine or decoction of Chinese medicine for ≥ 28 d. General information (age, sex, contact details), TCM use and endpoint events of AMI + DM patients during hospitalization and follow-up were collected. The correlation between TCM and the end-point events of AMI + DM patients was analyzed using a multiple logistic regression method.</p></div><div><h3>RESULTS</h3><p>A total of 479 AMI + DM patients were enrolled and 345 cases were followed up. During hospitalization, TCM, age, hypertension and use of an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) were associated with cardiac death. During follow-up, TCM was associated with cardiac death. TCM was a relevant factor for a composite endpoint of re-infarction and stroke. TCM, anti-thrombotic therapy and lipid-lowering therapy were related to acute heart failure. TCM, anti-thrombotic therapy, anti-MI therapy and ACEI/ARB use exhibited a strong correlation with re-hospitalization due to cardiovascular disease.</p></div><div><h3>CONCLUSION</h3><p>TCM reduced the prevalence of cardiac death during hospitalization, and cardiac death, a composite endpoint of re-infarction and stroke, acute heart failure and re-hospitalization due to cardiovascular disease during follow-up.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 412-418"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30632-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81905809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jinghua Weikang capsule protects against Helicobacter pylori-induced inflammatory responses via the nuclear factor-kappa B signaling pathway","authors":"Shi Zongming ,&nbsp;Ye Hui ,&nbsp;Yu Jing ,&nbsp;Cheng Hong ,&nbsp;Li Jiang ,&nbsp;Zhang Xuezhi","doi":"10.1016/j.jtcm.2018.03.001","DOIUrl":"10.1016/j.jtcm.2018.03.001","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the inhibitory effect of Jinghua Weikang capsule (JWC) on gastric inflammation induced by Helicobacter pylori (H. pylori) <em>via</em> the nuclear factor-kappa B (NF-κB) signaling pathway in Kunming mice.</p></div><div><h3>METHODS</h3><p>We investigated the anti-inflammation potential of JWC extract <em>in vivo</em> in a H. pylori-induced gastritis mouse model. The expression of inflammation-related molecules was evaluated by Western blotting, and the concentrations of <em>in vivo</em> inflammatory markers were measured by enzyme-linked immunosorbent assay. Inflammatory cell infiltration was evaluated by histopathological examination, and mRNA levels of related genes were evaluated by quantitative reverse transcription polymerase chain reaction.</p></div><div><h3>RESULTS</h3><p>JWC had a dose-dependent protective effect against H. pylori-induced gastritis by protecting gastric epithelial cells and inhibiting inflammatory cell infiltration. Mechanistically, JWC decreased the protein levels of phosphorylated IκBα and NF-κB p65, mRNA levels of NF-κB pathway molecules, and plasma levels of tumor necrosis factor-α and interleukin 1 beta.</p></div><div><h3>CONCLUSION</h3><p>An important finding of our study is that JWC attenuated gastrointestinal inflammation and ulceration and exerted a protective effect against gastric injury <em>via</em> inhibition of inflammation reactions and regulating the canonical NF-κB signaling pathway <em>in vivo.</em></p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 366-372"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2018.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46953765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of spleen-invigorating, Qi-replenishing and blood-arresting formula on zebrafish models with simvastatin-induced hemorrhage caused by spleen failing to control blood, in terms of theory of Traditional Chinese Medicine","authors":"Gao Chong ,&nbsp;Wang Jun ,&nbsp;Wang Jia ,&nbsp;Zhu Xiaoyu ,&nbsp;Zhu Changle ,&nbsp;Guo Shengya ,&nbsp;Wang Chong ,&nbsp;Fan Qiuyue ,&nbsp;Zhang Jianuo ,&nbsp;Xia Bo ,&nbsp;Chen Xinyi","doi":"10.1016/S0254-6272(18)30630-7","DOIUrl":"10.1016/S0254-6272(18)30630-7","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the hemostasis effect of spleen-invigorating, <em>Qi</em>-replenishing and blood-arresting formula, on a zebrafish models with simvastatin-induced hemorrhage, and with symptom pattern caused by spleen failing to control blood, in terms of theory of Traditional Chinese Medicine (TCM).</p></div><div><h3>METHODS</h3><p>In the first experiment, 60 AB strain wild type zebrafishes were randomly assigned into two groups: normal group and model group. The model group was treated with 50 μM simvastatin for 24 h. The second experiment: The melanin allele mutated Albino strain zebrafishes were divided into normal, model, A group and B group. The observational parameters were as follows: blood flow, velocity of movement, hemorrhage ratio and improvement ratio of hemorrhage.</p></div><div><h3>RESULTS</h3><p>Hemorrhage ratio: in the first experiment, brain hemorrhage ratio was 75%. In the second experiment, heart hemorrhage ratio was 65%. Blood flow: compared with the normal group, there was a significantly decrease in the model group (<em>P</em> &lt; 0.001). Velocity of movement: in the first experimental, compared with the normal group, there was a significantly decrease in the model group (<em>P</em> &lt; 0.001). Improvement ratio of hemorrhage: agents A had little effect in heart hemorrhage of the zebrafish; agents B could reduce heart hemorrhage ratio of the zebrafish, and increase the improvement ratio of hemorrhage.</p></div><div><h3>CONCLUSION</h3><p>The manifestation of zebrafish model with simvastatin-induced hemorrhage is basically similar to that of the clinical symptom pattern caused by spleen's failure to control blood. The Spleen-invigorating, <em>Qi</em>-replenishing and Blood-arresting Formula can reduce the heart hemorrhage ratio of zebrafish induced by simvastatin, and increase the Improvement ratio of hemorrhage.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 399-405"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30630-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43266101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of optimal combination of Huangqi (Radix Astragali Mongolici) and Ezhu (Rhizoma Curcumae Phaeocaulis) on proliferation and apoptosis of A549 lung cancer cells","authors":"Xu Chengyong ,&nbsp;Wang Yuguo ,&nbsp;Feng Jian ,&nbsp;Qin Li ,&nbsp;Xu Ran ,&nbsp;Dou Yongqi","doi":"10.1016/S0254-6272(18)30625-3","DOIUrl":"10.1016/S0254-6272(18)30625-3","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the effect of optimal combination (E) of Huangqi (<em>Radix Astragali Mongolici</em>) and Ezhu (<em>Rhizoma Curcumae Phaeocaulis</em>) on proliferation and apoptosis of A549 lung cancer cells and the possible mechanism underpinning the action.</p></div><div><h3>METHODS</h3><p>A uniform design method was used to optimize the E of Huangqi (<em>Radix Astragali Mongolici</em>) and Ezhu (<em>Rhizoma Curcumae Phaeocaulis</em>) in A549 lung cancer cells. MTS assay was applied to analyze the effect of the component formula of Huangqi (<em>Radix Astragali Mongolici</em>) and Ezhu (<em>Rhizoma Curcumae Phaeocaulis</em>) on A549 cells viability in various uniform design groups. A549 cells with exponential growth in routine culture were exposed to CoCl₂ (200 μmol/L) to mimic hypoxic conditions. Group 0 was treated with RPMI-1640, the group CoCl₂ was treated with CoCl₂ (200 μmol/L), the group DDP + CoCl₂ was treated with 4 mg/L Cisplatin injection (DDP) + CoCl₂ (200 μmol/L), and the drug group was treated with various dose of E (0.5E, 1E, 2E) + CoCl₂ (200 μmol/L). All groups were cultured for 24 h. Cell apoptosis was measured by Annexin V-FITC/propidium iodide double staining and flow cytometry. Western blot assay and quantitative real-time polymerase chain reaction (qRT-PCR) were employed to detect the protein and mRNA expression of B-celllymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteinyl aspartate specific proteinase-3 (caspase-3).</p></div><div><h3>RESULTS</h3><p>The E obtained by the uniform design was comprise of 200 mg/L Astragalus polysaccharide (X1) and 32 mg/L Curcumin (X3). Group DDP+ CoCl2, group 1E + CoCl₂ and group 2E + CoCl2 promoted the apoptosis of A549 cells (<em>P</em> &lt; 0.05). Group 1E + CoCl₂ and group 2E + CoCl₂ had no statistically significant differences compared with the group DDP + CoCl₂ (<em>P</em> &gt; 0.05). Compared with group 0, various doses of E + CoCl₂ could up-regulate the expression of Bax and caspase-3 and down-regulate the expression of Bcl-2 at protein and mRNA levels (<em>P</em> &lt; 0.05).</p></div><div><h3>CONCLUSION</h3><p>Astragalus polysaccharide and Curcumin was the optimal combination of Huangqi (<em>Radix Astragali Mongolici</em>) and Ezhu (<em>Rhizoma Curcumae Phaeocaulis</em>). E promoted the apoptosis of A549 cells. Combination of Astragalus polysaccharide and Curcumin increased the expression of Bax and caspase-3, and decreased the expression of Bcl-2 to initiate apoptosis in A549 cells under chemical-induced hypoxia.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 351-358"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30625-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43596924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persian medicine non-pharmacological therapies for headache: phlebotomy and wet cupping","authors":"Akramo Sadat Atyabi ,&nbsp;Fatemeh Nejatbakhsh ,&nbsp;Hoorie Mohammadi Kenari ,&nbsp;Fatemeh Eghbalian ,&nbsp;Mohammad Hossein Ayati ,&nbsp;Laila Shirbeigi","doi":"10.1016/S0254-6272(18)30639-3","DOIUrl":"10.1016/S0254-6272(18)30639-3","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To describe the common causes of headache as well as the different methods of Phlebotomy (Fasd) and wet Cupping (Hijamat) based on Persian Medicine.</p></div><div><h3>METHODS</h3><p>In this study, we searched Google Scholar, Science Direct, PubMed and Scopus to get any in vitro or clinical evidence of the efficacy and possible mechanisms of phlebotomy or wet cupping on different types of headaches. Also different types of headaches, according to PM, under the title of “Sodaa”; extracted from famous Persian medical text books with key words including “Sodaa”, “Bayze” and “Shaqiqe”.</p></div><div><h3>RESULTS</h3><p>According to PM, diseases (dystemperament) are created by abnormal alteration in temperament. Temperament is a monolithic quality yielded by interaction between opposing qualities of four elements that are coldness, hotness, dryness and wetness. Headaches are caused by dystemperament (sue-Mizaj) in brain or in total body that are divided into simple and corporal. Common forms of the latter type are Vaporal and Migrant headache (Bokhari and Rihi). Each of these headaches is treated either through phlebotomy or wet cupping.</p></div><div><h3>CONCLUSION</h3><p>In Persian Medicine, Fasd and Hijamat are easy and economical methods for treatment of headache with reasonable results. By describing the precise areas and indications of phlebotomy and wet cupping, this study provides the first step for future clinical trials in this field.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 457-464"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30639-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47172701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twirling reinforcing-reducing manipulation — central mechanism underlying antihypertensive effect on spontaneous hypertension in rats","authors":"Guo Qiulei ,&nbsp;Liu Qingguo ,&nbsp;Sun Dongmei ,&nbsp;Nie Binbin","doi":"10.1016/S0254-6272(18)30629-0","DOIUrl":"10.1016/S0254-6272(18)30629-0","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation (TRRM) might be the central mechanism underlying the action.</p></div><div><h3>METHODS</h3><p>In the study, <span>¹⁸</span>F-2-fluoro-deoxy-D-glucose positron emission tomography (<span>¹⁸</span>F-FDG-PET) was employed. Fifity-six spontaneous hypertensive rats (SHRs) were randomly divided into a model group, a single-needle acupuncture (SNA) group, a twirling reinforcing group (SNA + TRF) and a twirling reducing (SNA + TRD) group. Fourteen Wistar rats were assigned to the control group. The acupuncture intervention at Taichong (LR 3) acupoint was administered once daily in the SNA, SNA + TRF and SNA + TRD groups for 14 days, with 1 d interval between the two weeks. The blood pressure (BP) of all rats was measured repeatedly and <span>¹⁸</span>F-FDG-PET scans were conducted on the 14th day. PET images were processed with Statistical Parametric Mapping 8.0.</p></div><div><h3>RESULTS</h3><p>After the intervention, systolic BP showed a significant decrease in the SNA, SNA+TRF and SNA + TRD versus the model groups (all <em>P</em> &lt; 0.01) and in the SNA + TRF and SNA + TRD versus the SNA groups (both <em>P</em> &lt; 0.01), with the SNA + TRD group exhibited the best antihypertensive effect (<em>P</em> &lt; 0.01). The key brain regions activated by TRRM were mainly concentrated in the cerebellum, hippocampus, hypothalamus, medulla oblongata, insular cortex, midbrain, thalamus and visual cortex.</p></div><div><h3>CONCLUTION</h3><p>TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 391-398"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30629-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43465907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Traditional Chinese Medicine Four-diagnostic auxiliary apparatus in evaluation of health status and clinical treatment","authors":"Chen Tianyu ,&nbsp;Niu Tingli ,&nbsp;Niu Xin ,&nbsp;Si Yingchu ,&nbsp;Yang Xuezhi ,&nbsp;Ma Liangxiao","doi":"10.1016/S0254-6272(18)30637-X","DOIUrl":"10.1016/S0254-6272(18)30637-X","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To evaluate the application of Traditional Chinese Medicine (TCM) Four-diagnostic Auxiliary Apparatus in disease diagnosis.</p></div><div><h3>METHODS</h3><p>The liver cancer patients and healthy controls were recruited from Shanghai Integrated Chinese and Western Medicine Hospital and Beijing University of Traditional Chinese Medicine, respectively. Then, the included subjects were diagnosed by the Four-diagnostic auxiliary apparatus.</p></div><div><h3>RESULTS</h3><p>Thirty liver cancer patients and 30 paired healthy controls were enrolled in this study. Based on the apparatus, the pulse wave velocity was significantly higher in patients compared with controls (<em>P</em> &lt; 0.05). The number of patients with purple tongue and ecchymosis were more than controls (<em>P</em> &lt; 0.05). The number of patients (10%) with yellow tongue coating were higher than the controls (0%). Patients were inclined to be with water type and fire type constitution.</p></div><div><h3>CONCLUSION</h3><p>TCM Four-diagnostic auxiliary apparatus can be applied in clinical diagnosis of body constitution and health status of subjects. It promotes the accuracy and speed for disease diagnosis and TCM standardization.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 447-451"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30637-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76064896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Sini decoction on angiotensin II, transforming growth factor β1 and connective tissue growth factor in rats with myocardial fibrosis-induced banding of the abdominal aorta","authors":"Shi Yueping ,&nbsp;Zhai Jianli ,&nbsp;Liu Chunxiao","doi":"10.1016/S0254-6272(18)30634-4","DOIUrl":"10.1016/S0254-6272(18)30634-4","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the effect of Sini decoction on rats with myocardial fibrosis induced by banding the abdominal aorta, and explore the mechanism underlying its actions on angiotensin II (Ang II), transforming growth factor-β₁ (TGF-β₁) and connective tissue growth factor (CTGF).</p></div><div><h3>METHODS</h3><p>Forty-eight male Sprague-Dawley rats were randomly divided into sham operation, model, Captopril, and Sini decoction groups. The models were established by the partial banding of the abdominal aorta according to Doering's method. Eight weeks later, heart weight indexes were calculated; hemodynamic changes of the hearts were tested; changes in myocardial tissue morphology were observed by Masson staining; and myocardial collagen volume fraction was calculated. Enzyme-linked immunosorbent assay was used to measure the concentration of Ang II in serum. The expression of TGF-β₁ and CTGF were determined by immunohistochemistry and Western blotting.</p></div><div><h3>RESULTS</h3><p>Compared with the sham operation group, the heart weight index, collagen volume fraction of the myocardium, serum levels of Ang II, and the expression of myocardial TGF-β₁ and CTGF in the model group were significantly increased (<em>P</em> &lt; 0.05). Compared with the model group, the heart weight index, collagen volume fraction of the myocardium, serum levels of Ang II, and the expression of myocardial TGF-β₁ and CTGF in all treatment groups were significantly reduced (<em>P</em> &lt; 0.05).</p></div><div><h3>CONCLUSION</h3><p>Sini decoction reduced Ang II level and inhibited the expression of myocardial TGF-β₁ and CTGF, which may explain the mechanism of its protective effect on myocardium with fibrosis.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 427-432"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30634-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43798310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}