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Optimizing blue poo: A validated, cost-effective method for measuring whole gut transit time 优化蓝色粪便:一种有效的,具有成本效益的方法来测量整个肠道运输时间
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-26 DOI: 10.1016/j.mex.2025.103741
Cyra Schmandt , Julia Trunz , Claudio Perret , Anneke Hertig-Godeschalk , Zeno Stanga , Jivko Stoyanov
Whole gut transit time (WGTT) provides essential insights into gastrointestinal health, but traditional measurement methods are often expensive or invasive. This study optimizes and validates the "blue dye method," an affordable and minimally invasive approach to WGTT measurement. Using "Hollinger Farbpulver Blau" (containing food colors E131 and E132), dye concentrations ranging from 30 mg to 241 mg were tested across four modes of delivery: capsule with liquid, gummy bear, muffin, and capsule with rice crackers and liquid. Each presented limitations: capsules taken with liquid led to inconsistent transit times, gummy bears caused staining, and muffins were perishable. Measured WGTTs varied between 18 and 29 h depending on the mode of delivery and dye concentration. Optimal protocol was a capsule containing 60 mg of dye taken with two rice crackers and liquid, ensuring accurate detection without practical inconveniences. The standardized and optimized blue dye method provides valid WGTT measurements, making it well suited for large-scale population studies and clinical applications.
Uses a simple blue dye as a marker for gut transit.
Tested several modes of delivery and concentrations to find the most practical option.
Established a standardized protocol for reliable and reproducible measurement.
全肠道传递时间(WGTT)提供了对胃肠道健康的重要见解,但传统的测量方法往往昂贵或具有侵入性。本研究优化并验证了“蓝色染料法”,这是一种经济实惠且微创的WGTT测量方法。使用“Hollinger Farbpulver Blau”(含有食用色素E131和E132),染料浓度从30毫克到241毫克,测试了四种递送模式:液体胶囊、小熊软糖、松饼胶囊和米饼和液体胶囊。每一种都有局限性:胶囊与液体一起服用会导致运输时间不一致,小熊软糖会引起染色,松饼容易变质。根据递送方式和染料浓度的不同,测得的wgtt在18至29小时之间变化。最佳方案为含60毫克染料的胶囊,用两个米饼和液体服用,确保准确检测而不带来实际不便。标准化和优化的蓝色染料方法提供了有效的WGTT测量,使其非常适合大规模人群研究和临床应用。用一种简单的蓝色染料作为肠道运输的标记。测试了几种给药方式和浓度,以找到最实用的选择。建立了可靠和可重复测量的标准化方案。
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引用次数: 0
EcoCondition Toolset - A QGIS plugin for ecosystem condition assessments. EcoCondition Toolset -一个用于生态系统状况评估的QGIS插件。
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-25 eCollection Date: 2025-12-01 DOI: 10.1016/j.mex.2025.103734
Luís Valença Pinto, Miguel Inácio, Fernando Santos-Martín, Benjamin Burkhard, Paulo Pereira

Ecosystem condition can be understood as the quality of an ecosystem in terms of its abiotic, biotic, and landscape characteristics. It is a measure of structural integrity, functional capacity, and resilience of any given ecological system. Its assessment is essential to support environmental objectives (e.g., nature restoration or sustainable use). Spatially explicit assessment of ecosystem condition requires integrating diverse geospatial data. Here, we present the EcoCondition Toolset, a QGIS plugin implementing a user-friendly GIS weighted-sum methodology for ecosystem condition assessments. It simplifies data preparation and analysis through five sequential toolsets: i) layer alignment and resampling; ii) no-data handling; iii) multicollinearity testing; iv) indicator normalisation and inversion; and v) condition assessment. The plugin calculates six specific ecosystem attribute - or state - composites (Physical, Chemical, Compositional, Structural, Functional, Landscape) from user-selected variables (in raster format), according to the System of Environmental-Economic Accounting. After data preparation and verification, the tool displays default equal weights for each composite and related variables, which users can adjust (e.g., to reflect stakeholder preferences). The toolset automates best-practice multicollinearity screening, normalisation, and flexible weighting for ecosystem condition assessment and monitoring. The resulting index preserves true severity and variation among ecosystem states. The results can support robust policy instruments and land-use decision-making, prioritising conservation and restoration actions.

生态系统条件可以理解为一个生态系统在其非生物、生物和景观特征方面的质量。它是衡量任何给定生态系统的结构完整性、功能能力和复原力的标准。它的评价对于支持环境目标(例如,自然恢复或可持续利用)是必不可少的。生态系统状况的空间显式评价需要综合多种地理空间数据。在这里,我们提出了生态条件工具集,这是一个QGIS插件,实现了一个用户友好的GIS加权和方法,用于生态系统状况评估。它通过五个连续的工具集简化了数据准备和分析:1)层对齐和重新采样;Ii)无数据处理;Iii)多重共线性检验;Iv)指标归一化和反转;v)条件评估。根据环境经济核算系统,该插件从用户选择的变量(栅格格式)中计算六种特定的生态系统属性或状态复合(物理、化学、成分、结构、功能、景观)。在数据准备和验证之后,工具为每个组合和相关变量显示默认的相等权重,用户可以调整(例如,反映涉众偏好)。该工具集自动化了最佳实践多重共线性筛选、归一化和灵活加权,用于生态系统状况评估和监测。由此得出的指数保留了生态系统状态之间的真实严重性和变化。研究结果可以支持强有力的政策工具和土地利用决策,优先考虑保护和恢复行动。
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引用次数: 0
The relationship between activities of daily living performance and self-efficacy among clients with hand injury in Indian context- A cross-sectional study protocol. 印度背景下手部损伤患者日常生活活动表现与自我效能感的关系——一项横断面研究方案。
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-22 eCollection Date: 2025-12-01 DOI: 10.1016/j.mex.2025.103732
Shejal A Rao, Koushik Sau, Shovan Saha, Vani R Lakshmi, Ashwath M Acharya

Hand injuries are among the most common musculoskeletal injuries and can significantly impair an individual's ability to perform activities of daily living (ADL), thereby impacting quality of life. Self-efficacy plays a vital role in influencing daily performance and recovery following injury. This cross-sectional study aims to explore the relationship between ADL performance and self-efficacy among clients with hand injuries within the Indian context. Secondary objectives of this study include assessing self-efficacy levels and evaluating ADL performance in this population. • A self-administered, closed-ended, structured questionnaire comprising performance-based and self-efficacy measures will be used for data collection. Participants will include adults aged 18 years and above who have sustained fractures of the hand or wrist, including digits, and have undergone surgical treatment. • Clients will be recruited from the Occupational Therapy department. • The findings aim to highlight the importance of considering both objective and subjective measures in occupational therapy assessment and to emphasize the role of self-efficacy in ADL performance following hand injuries, potentially informing culturally sensitive rehabilitation interventions.

手部损伤是最常见的肌肉骨骼损伤之一,可严重损害个人日常生活活动(ADL)的能力,从而影响生活质量。自我效能感在影响受伤后的日常表现和恢复方面起着至关重要的作用。本横断面研究旨在探讨在印度背景下手部受伤的客户的ADL表现和自我效能之间的关系。本研究的次要目的包括评估该人群的自我效能水平和ADL表现。•数据收集将使用自我管理的封闭式结构化问卷,包括基于绩效和自我效能的测量。参与者将包括18岁及以上的手部或手腕(包括手指)持续骨折并接受过手术治疗的成年人。•客户将从职业治疗部门招募。•研究结果旨在强调在职业治疗评估中考虑客观和主观测量的重要性,并强调自我效能感在手部受伤后ADL表现中的作用,可能为文化敏感的康复干预提供信息。
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引用次数: 0
Advanced spatio temporal modeling with geographically and temporally weighted spline regression (GTWSR) for strategic food price forecasting in Indonesia. 基于地理和时间加权样条回归(GTWSR)的印尼粮食价格战略预测先进时空模型。
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-21 eCollection Date: 2025-12-01 DOI: 10.1016/j.mex.2025.103727
Sifriyani, I Nyoman Budiantara, Krishna Purnawan Candra, Syaripuddin, Syatirah Jalaluddin, Mariani Rasjid, Ruslan

This study proposes an advanced spatio-temporal framework to forecast strategic food commodity prices in Indonesia using Geographically and Temporally Weighted Spline Regression (GTWSR), a nonparametric extension of GTWR designed to capture nonlinear spatio temporal effects. Monthly data from the Strategic Food Price Information Center (SFPIC) and Statistics Indonesia (BPS), covering eight key commodities and the Farmer Price Index across 34 provinces (January 2022-August 2024), were analyzed through spatial distance measurement, bandwidth optimization, local parameter estimation, and statistical validation. The GTWSR model demonstrated strong predictive performance (overall accuracy: R² = 91.61 %, RMSE = 1.22, MAE = 0.94, MAPE = 3.7 %), with rice and garlic achieving the highest accuracy, while red and cayenne chili showed greater errors due to price volatility. Spatial disparities were evident, as eastern provinces such as Papua, Maluku, and East Nusa Tenggara consistently faced higher prices compared to western regions. These findings underscore the need for region-specific interventions to strengthen logistics and stabilize horticultural supply chains. Limitations include reliance on monthly aggregated data, the temporal scope ending in 2024, and dependence on secondary datasets, which may affect replication and long-term applicability.

本研究提出了一个先进的时空框架,利用地理和时间加权样条回归(GTWSR)预测印度尼西亚的战略粮食商品价格,GTWSR是GTWR的非参数扩展,旨在捕捉非线性时空效应。通过空间距离测量、带宽优化、局部参数估计和统计验证,对来自战略食品价格信息中心(SFPIC)和印度尼西亚统计局(BPS)的月度数据进行了分析,涵盖了8种关键商品和34个省份的农民价格指数(2022年1月至2024年8月)。GTWSR模型显示出较强的预测性能(总体准确率:R²= 91.61%,RMSE = 1.22, MAE = 0.94, MAPE = 3.7%),其中大米和大蒜的预测准确率最高,而红辣椒和辣椒由于价格波动的影响,预测误差较大。空间差异很明显,东部省份如巴布亚省、马鲁古省和东努沙登加拉省的价格一直高于西部地区。这些发现强调需要采取针对特定区域的干预措施,以加强物流和稳定园艺供应链。限制包括依赖每月汇总数据,时间范围截止于2024年,以及依赖辅助数据集,这可能会影响复制和长期适用性。
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引用次数: 0
Plating larval zebrafish prior to the day of experimentation has no impact on spontaneous swimming and startle responses. 在实验当天之前对斑马鱼幼鱼进行电镀对其自发游泳和惊吓反应没有影响。
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-19 eCollection Date: 2025-12-01 DOI: 10.1016/j.mex.2025.103730
Matthew M M Harper, Ethan V Hagen, Yanbo Zhang, Trevor J Hamilton

Behavioural testing in larval zebrafish often involves pipetting the larvae into well plates for individual testing. Transferring larvae into plates the day prior to experimentation can increase efficiency of testing. Furthermore, pharmacological and toxicological studies can require a prolonged dosing period requiring the larvae to be pre-plated into the well plate the day prior to experimentation. Here, we compared the behavioural impact of pre-plating larval zebrafish at 4 days post-fertilization (dpf) to fish transferred at 5 dpf on the day of testing. Motion-tracking software was used to examine locomotion and zone preference, and responses to light, dark, and mechanical startle stimuli. We found no significant differences in distance moved, time spent in the thigmotaxis zone (outside edge of the arena), high mobility, immobility, light startle, dark startle, and mechanical startle responses. This data suggests that pre-plating larval zebrafish one day prior to testing does not have a significant impact on behaviour in a spontaneous swim task, dark startle test, light startle test, or mechanical startle test. Pre-plating larval zebrafish can increase the efficiency of behavioural testing.•Compare plating larvae one day prior to testing to plating day of testing.•Test the behaviour in a spontaneous swimming test, and measure light-, dark-, and mechanical-startle responses.•There were no significant differences in locomotion or startle responses.

斑马鱼幼虫的行为测试通常包括将幼虫移液到孔板中进行个体测试。实验前一天将幼虫转入培养皿可提高试验效率。此外,药理学和毒理学研究可能需要延长给药时间,要求在实验前一天将幼虫预先镀到孔板中。在这里,我们比较了受精后4天(dpf)的预镀幼鱼对试验当天5 dpf转移的鱼的行为影响。运动跟踪软件用于检查运动和区域偏好,以及对光、暗和机械惊吓刺激的反应。我们发现,在移动距离、在移动性区域(竞技场外边缘)停留的时间、高移动性、不移动性、光惊吓、暗惊吓和机械惊吓反应方面没有显著差异。这一数据表明,在测试前一天预镀斑马鱼幼虫对自发游泳任务、暗惊吓测试、光惊吓测试或机械惊吓测试中的行为没有显著影响。预镀斑马鱼幼鱼可以提高行为测试的效率。•将测试前一天的电镀幼虫与测试当天的电镀幼虫进行比较。•在自发游泳测试中测试行为,并测量光,暗和机械惊吓反应。•在运动或惊吓反应方面没有显著差异。
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引用次数: 0
From detection to grading: A hybrid KOA-YOLOv5-RF model for knee osteoarthritis diagnosis. 从检测到分级:KOA-YOLOv5-RF混合模型对膝关节骨关节炎的诊断。
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-19 eCollection Date: 2025-12-01 DOI: 10.1016/j.mex.2025.103725
Manikandaprabhu Perumalsamy, Priya Govindarajan, Rinhas Bran, Adarsh Krishna Kp, Niranjan V Jyothi, M Batumalay

This study presents a novel computer-aided diagnostic (CAD) system for detecting and grading the severity of knee osteoarthritis(KOA) from X-ray images, utilizing a hybrid deep learning and machine learning framework. The system combines YOLOv5 for precise knee joint localization and segmentation with a Random Forest classifier for ordinal Kellgren-Lawrence (KL) grading. Trained on a curated and augmented dataset of 1535 X-ray images, the model achieves an overall KL grading accuracy of 87 %. Evaluation includes ROC-AUC curves, Cohen's kappa scores, and grade-wise sensitivity and specificity metrics. This hybrid approach offers a scalable, interpretable, and clinically relevant tool for supporting radiologists in early KOA diagnosis, especially in resource-constrained settings.•Combines the powerful feature extraction capabilities of the YOLOv5 deep learning architecture with the classification strength of the Random Forest model.•YOLOv5 is used for knee joint segmentation to reduce background noise and improve classifier accuracy by focusing on the region of interest.•Achieves 87 % overall accuracy in KL grading, with enhanced sensitivity to subtle changes in early-stage KOA (Grades 1-2).

本研究提出了一种新的计算机辅助诊断(CAD)系统,用于从x射线图像中检测和分级膝关节骨关节炎(KOA)的严重程度,利用混合深度学习和机器学习框架。该系统结合了YOLOv5的精确膝关节定位和分割,以及随机森林分类器的有序Kellgren-Lawrence (KL)分级。该模型在1535张x射线图像的精选和增强数据集上进行训练,总体KL分级准确率达到87%。评估包括ROC-AUC曲线、Cohen's kappa评分、分级敏感性和特异性指标。这种混合方法提供了一种可扩展的、可解释的和临床相关的工具,用于支持放射科医生进行KOA的早期诊断,特别是在资源有限的情况下。•将YOLOv5深度学习架构强大的特征提取能力与随机森林模型的分类强度相结合。•YOLOv5用于膝关节分割,通过关注感兴趣的区域来减少背景噪声并提高分类器的准确性。•KL分级的总体准确率达到87%,对早期KOA(1-2级)的细微变化具有更高的敏感性。
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引用次数: 0
A methodological framework for road accident severity prediction for indian highways using machine learning models. 使用机器学习模型预测印度高速公路道路事故严重程度的方法框架。
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-19 eCollection Date: 2025-12-01 DOI: 10.1016/j.mex.2025.103728
Humera Khanum, Anshul Garg, Mir Iqbal Faheem, Rushikesh Kulkarni

This study introduces a methodological framework for predicting road accident severity using a SHAP-enhanced Machine Learning model. Road traffic accidents remain a major global concern, with India reporting over 150,000 fatalities annually. Traditional models fail to capture the complex relationships among various risk factors. This research applies machine learning, specifically Random Forest and Gradient Boosting, to identify and analyse key factors influencing accident severity. SHAP values are used to enhance model interpretability, providing insights into the contribution of each feature.•Develop a Random Forest model and a Gradient Boosting model to predict road accident severity based on a comprehensive set of features.•Utilise SHAP to identify and rank the importance of features, such as vehicle type, weather, and road conditions.•Model performance is evaluated using accuracy, precision, recall, F1-score, and confusion matrices. Polynomial curve fits are used only as post-hoc visualizations of the Actual-Predicted relationship (on ordinal codes), not as classifier evaluation metrics.The findings highlight that factors like vehicle type, accident location, and road conditions significantly influence accident severity. This approach provides a scalable and interpretable framework for improving road safety on Indian highways, offering data-driven insights for proactive safety measures and infrastructure enhancements.

本研究介绍了一种方法框架,用于使用shap增强的机器学习模型预测道路交通事故严重程度。道路交通事故仍然是全球关注的一个主要问题,印度每年报告的死亡人数超过15万人。传统模型无法捕捉各种风险因素之间的复杂关系。本研究应用机器学习,特别是随机森林和梯度增强,来识别和分析影响事故严重程度的关键因素。SHAP值用于增强模型的可解释性,提供对每个特征的贡献的见解。•开发一个随机森林模型和一个梯度增强模型,基于一组综合特征来预测道路事故的严重程度。•利用SHAP识别和排序特征的重要性,如车辆类型,天气和道路状况。•使用准确性,精度,召回率,f1分数和混淆矩阵评估模型性能。多项式曲线拟合仅用作实际预测关系的事后可视化(在序数代码上),而不是作为分类器评估指标。研究结果强调,车辆类型、事故地点和道路状况等因素对事故严重程度有显著影响。该方法为改善印度高速公路的道路安全提供了一个可扩展和可解释的框架,为主动安全措施和基础设施改进提供了数据驱动的见解。
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引用次数: 0
Hybrid deep learning and machine learning framework for automated pneumonia detection in chest X-ray images. 用于胸部x射线图像中肺炎自动检测的混合深度学习和机器学习框架。
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-19 eCollection Date: 2025-12-01 DOI: 10.1016/j.mex.2025.103729
Akshay S, Sneha Kashyap, Danikk Patel H N, Pavan Kumar Y R

Pneumonia is a dangerous respiratory illness that has to be precisely and promptly diagnosed in order to be treated effectively and prevent consequences. In order to distinguish between pneumonic and normal chest X-ray pictures, a hybrid deep learning technique is proposed in this study. For efficient and complementary feature extraction, the proposed system leverages the strengths of two popular convolutional neural networks, VGG16 and ResNet. Before training the model, the image is enhanced and the lungs are segmented by performing histogram equalisation, normalising contrast, and converting to grayscale. A richer feature representation of input photos is produced by fusing the features of VGG16 and ResNet. A model for identifying pneumonia is classified using the fused feature set. The system processes X-rays of new patients in order to extract features and categorise them using Random Forest (RF) and Support Vector Machine (SVM) classifiers. To increase accuracy and efficiency, feature dimensions are optimised using Principal Component Analysis (PCA). Key Contributions: 1. Dual-CNN feature fusion (VGG16 + ResNet) instead of single-model learning 2. PCA-based dimensionality optimization retaining 95% variance 3. Use of SVM and Random Forest for more interpretable diagnosis instead of CNN softmax.

肺炎是一种危险的呼吸道疾病,必须准确和及时地诊断,以便有效治疗和预防后果。为了区分肺炎和正常胸部x线图像,本研究提出了一种混合深度学习技术。为了高效和互补的特征提取,该系统利用了两种流行的卷积神经网络VGG16和ResNet的优势。在训练模型之前,通过执行直方图均衡化、对比度归一化和灰度转换对图像进行增强和肺分割。通过融合VGG16和ResNet的特征,生成更丰富的输入照片特征表示。利用融合特征集对肺炎识别模型进行分类。该系统处理新患者的x射线以提取特征并使用随机森林(RF)和支持向量机(SVM)分类器对其进行分类。为了提高准确性和效率,使用主成分分析(PCA)对特征尺寸进行优化。主要贡献:1;双cnn特征融合(VGG16 + ResNet)代替单模型学习基于pca的维数优化保留95%方差使用SVM和随机森林代替CNN softmax进行更可解释的诊断。
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引用次数: 0
Microwave head imaging systems for early brain tumor detection: antenna designs and emerging substrates. 用于早期脑肿瘤检测的微波头部成像系统:天线设计和新兴基板。
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-16 eCollection Date: 2025-12-01 DOI: 10.1016/j.mex.2025.103726
Jinu Mathew, Osamah Ibrahim Khalaf, Navin M George, Ancy Michel, Neethan Elizabeth Abraham, Deema Mohammed Alsekait, Sharf Alzu'bi, Diaa Salama AbdElminaam

Early detection of brain tumors is essential for successful treatment and better patient outcomes. Traditional imaging methods like X-rays, MRIs, CT scans, and PET scans have been important in detecting brain tumors, but they are expensive with many drawbacks and areas where access is limited. Antenna-based method has recently emerged as a practical alternative for real-time, non-invasive detection of brain tumors. This paper explores different antennas and various types of substrates that are adaptable to human sensitive tissues for detecting brain tumors. This review highlights the antenna working principles, and the advantages and challenges associated with each type. The effectiveness of several antenna-based methods in medical diagnostics, including microwave imaging and ultra-wideband (UWB) systems, is discussed. To assess their impact on detection accuracy, essential factors such as penetration depth, resolution, operating frequency, and antenna design are considered. The integration of antennas with machine learning and signal processing techniques is investigated.

早期发现脑肿瘤对于成功治疗和改善患者预后至关重要。传统的成像方法,如x射线、核磁共振、CT扫描和PET扫描,在检测脑肿瘤方面一直很重要,但它们价格昂贵,有许多缺点,而且进入的区域有限。基于天线的方法最近成为实时、非侵入性脑肿瘤检测的一种实用替代方法。本文探讨了不同的天线和各种类型的衬底,以适应人类敏感组织检测脑肿瘤。本文重点介绍了天线的工作原理,以及每种类型的优点和挑战。讨论了几种基于天线的医学诊断方法的有效性,包括微波成像和超宽带(UWB)系统。为了评估它们对探测精度的影响,需要考虑穿透深度、分辨率、工作频率和天线设计等基本因素。研究了天线与机器学习和信号处理技术的集成。
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引用次数: 0
Artificial inteligence and datasets for leukemia diagnosis: A scoping review of machine lerning and deep learning approaches. 白血病诊断的人工智能和数据集:机器学习和深度学习方法的范围审查。
IF 1.9 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-13 eCollection Date: 2025-12-01 DOI: 10.1016/j.mex.2025.103722
Ashwini Tande, Renuka Mane

Leukemia is the cancerous disease of the blood and the bone marrow that causes excessive proliferation of abnormal white blood cells, if detected too late, it can lead to potentially fatal consequences. Peripheral blood smear examinations and bone marrow biopsy are example of conventional diagnostic techniques that are invasive, time-consuming and subject to human variability. Recent advances in artificial intelligence (AI) particularly in the areas of Machine Learning (ML) and Deep Learning (DL)offer encouraging answers by making it possible to detect and classify leukemia using automated, effective and precise techniques. With an emphasis on image-based techniques based on publicly available datasets such as ALL-IDB, C-NMC, AML_Cytomorphology_LMU, SN-AM and CPTAC-AML, this paper reviews the most recent research on Machine Learning and Deep Learning approaches includes Convolutional Neural Networks (CNNS), ResNet, DenseNet, MobileNet and ensemble models for leukemia diagnosis. The survey highlights some of the most significant issues, such as dataset imbalance, stain variability, lack of standard annotations and limited clinical validation. The paper also discusses research gap and future initiatives including Explainable AI, lightweight deployment models, clinically reliable diagnostic system and hierarchical classification framework aligned with WHO 2022 classification standards.

白血病是一种导致异常白细胞过度增殖的血液和骨髓癌变疾病,如果发现得太晚,可能会导致潜在的致命后果。外周血涂片检查和骨髓活检是传统诊断技术的例子,这些技术是侵入性的,耗时的,并且受人类变化的影响。人工智能(AI)的最新进展,特别是在机器学习(ML)和深度学习(DL)领域,通过使用自动化、有效和精确的技术来检测和分类白血病,提供了令人鼓舞的答案。本文重点介绍了基于公开可用数据集(如ALL-IDB, C-NMC, AML_Cytomorphology_LMU, SN-AM和cptacl - aml)的基于图像的技术,回顾了机器学习和深度学习方法的最新研究,包括卷积神经网络(CNNS), ResNet, DenseNet, MobileNet和白血病诊断的集成模型。该调查强调了一些最重要的问题,如数据集不平衡、染色变异性、缺乏标准注释和有限的临床验证。本文还讨论了研究差距和未来举措,包括可解释的人工智能、轻量级部署模型、临床可靠的诊断系统和符合世卫组织2022分类标准的分层分类框架。
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