Anak Agung Pradnya Paramitha Vidiani, Lisa Aditama, Amelia Lorensia
Pasien penyakit kronis menjalani transisi pelayanan kesehatan, sehingga kesinambungan perawatan atau continuity of care (CoC) menjadi komitmen antar tenaga kesehatan. CoC diukur dari perspektif pasien berdasarkan pengalaman dalam pelayanan kesehatan terkait kesinambungan informasi, hubungan dan manajerial. Tujuan penelitian adalah melakukan kajian CoC pasien DM tipe 2 dan hipertensi PRB Puskesmas Kota Surabaya dan menggali pengalaman pasien dalam transisi pelayanan kesehatan. Rancangan penelitian adalah mixed methods. Sampel ditentukan secara purposive dengan memperhatikan kriteria penelitian. Pengumpulan data dilakukan dengan menggunakan kuesioner Cuestionario Continuidad Asistencial Entre Niveles de Atencion (CCAENA) dan wawancara semi-terstruktur. Kesinambungan hubungan berada pada tingkat yang tertinggi, dimana hubungan dengan dokter spesialis lebih tinggi (95%) dibandingkan dokter umum (74%). Ketidaksinambungan hubungan terbesar, yaitu tidak bisa berkonsultasi dengan dokter yang sama di Puskesmas (58%). Kesinambungan manajerial terkait koherensi perawatan (91%) dan aksesibilitas (79%). Ketidaksinambungan manajerial terbesar adalah tidak ada koherensi perawatan antara dokter spesialis dan dokter di Puskesmas (85%) serta aksesibilitas saat antri di rumah rakit (48%). Kesinambungan informasi berada pada tingkat paling rendah (73%). Ketidaksinambungan informasi terbesar adalah diskusi antara pasien dan dokter di Puskesmas terkait pengobatan setelah rujukan (37%). Kesimpulan dari penelitian ini adalah ketidaksinambungan dalam transisi perawatan pasien penyakit kronis terbesar adalah pemberian informasi. Apoteker memiliki peran penting untuk meningkatkan pelayanan informasi dan menjamin keselamatan pasien disetiap rantai perawatan. Transition of healthcare increases the risk of chronic disease patients, therefore continuity of care (CoC) is needed for patient care. CoC measure from the patient's perspective based on experience related to continuity of information, relationships and managerial. The purpose was to study of CoC patients with type 2 diabetes mellitus (T2DM) and hypertension referral program at the Surabaya City Public Health Center and explore patient experiences in transitioning health services. The design is mixed methods. The sample was determined purposively by observe into research criteria. Data collection was using the Cuestionario Continuidad Asistencial Entre Niveles de Atencion (CCAENA) questionnaire and semi-structured interviews. Relation continuity is the highest level, where relationships with specialist are higher (95%) than general prescriber (GP) (74%). The biggest discontinuity is not being able to consult the same GP (58%). Managerial continuity related to coherence of care (91%) and accessibility (79%). The biggest managerial discontinuity is coherence between specialist and GP (85%) and accessibility when queuing at the hospital (48%). Information continuity is the lowest level (73%). The bigges
慢性病患者正经历着医疗保健的过渡，因此持续的治疗或持续的护理成为卫生保健的承诺。CoC是根据患者的观点来衡量的，基于信息、关系和管理的持续性医疗服务的经验。该研究的目的是对DM型2型患者的CoC患者进行夹具研究，了解患者在医疗过渡中的经验。研究的设计是混合的方法。样本的目的是通过研究标准来确定。数据收集是通过专责问卷进行的，专责小组成员Entre Niveles de Atencion (CCAENA)和半结构化采访。持续性是最高的，与专家的关系比一般医生(74%)更高。最大的不连续性是不能在Puskesmas咨询同一位医生(58%)。负责维护一致性的管理连续性(91%)和可及性(79%)。最大的管理障碍是Puskesmas的专家和医生(85%)之间的治疗不一致，在等待救生筏的时候可获得性(48%)。信息的传播速度最低(73%)。最大的信息不连续性是口诊后患者和医生之间关于治疗的讨论(37%)。这项研究的结论是，最大的慢性病患者治疗过渡的不连续性是提供信息。药剂师在改善信息服务和确保每个护理链患者的安全方面发挥着重要作用。治疗治疗的转变增加了慢性疾病的风险，这就是持续护理所需要的。对病人的了解取决于持续的信息、关系和管理。目的是研究泗水市公共卫生中心的2型糖尿病和高血压推荐项目。设计是混合的方法。样本是由观察到的重点研究对象决定的。数据集合使用的是连续的问题助理Entre Niveles de Atencion (CCAENA)提问并进行半结构性采访。持续的关系是最极端的，与专家的关系比总攻(74%)更高。最大的持续困难是不能咨询同样的医生(58%)。持续管理与关爱相关(91%)和包容(79%)。最大的管理不稳定是专家和全科医生(85%)在住院期间的协调(48%)。信息继续保持较低水平(73%)。最严重的分歧是病人和家庭医生在推荐后寻求治疗(37%)之间的严重分歧。这项研究的结论是对慢性疾病患者的治疗史上最严重的分歧是信息。药房有一个重要的信息服务和保险。
{"title":"Kajian Continuity of Care Pasien Program Rujuk Balik di Puskesmas Kota Surabaya","authors":"Anak Agung Pradnya Paramitha Vidiani, Lisa Aditama, Amelia Lorensia","doi":"10.24123/mpi.v5i1.5484","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5484","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000Pasien penyakit kronis menjalani transisi pelayanan kesehatan, sehingga kesinambungan perawatan atau continuity of care (CoC) menjadi komitmen antar tenaga kesehatan. CoC diukur dari perspektif pasien berdasarkan pengalaman dalam pelayanan kesehatan terkait kesinambungan informasi, hubungan dan manajerial. Tujuan penelitian adalah melakukan kajian CoC pasien DM tipe 2 dan hipertensi PRB Puskesmas Kota Surabaya dan menggali pengalaman pasien dalam transisi pelayanan kesehatan. Rancangan penelitian adalah mixed methods. Sampel ditentukan secara purposive dengan memperhatikan kriteria penelitian. Pengumpulan data dilakukan dengan menggunakan kuesioner Cuestionario Continuidad Asistencial Entre Niveles de Atencion (CCAENA) dan wawancara semi-terstruktur. Kesinambungan hubungan berada pada tingkat yang tertinggi, dimana hubungan dengan dokter spesialis lebih tinggi (95%) dibandingkan dokter umum (74%). Ketidaksinambungan hubungan terbesar, yaitu tidak bisa berkonsultasi dengan dokter yang sama di Puskesmas (58%). Kesinambungan manajerial terkait koherensi perawatan (91%) dan aksesibilitas (79%). Ketidaksinambungan manajerial terbesar adalah tidak ada koherensi perawatan antara dokter spesialis dan dokter di Puskesmas (85%) serta aksesibilitas saat antri di rumah rakit (48%). Kesinambungan informasi berada pada tingkat paling rendah (73%). Ketidaksinambungan informasi terbesar adalah diskusi antara pasien dan dokter di Puskesmas terkait pengobatan setelah rujukan (37%). Kesimpulan dari penelitian ini adalah ketidaksinambungan dalam transisi perawatan pasien penyakit kronis terbesar adalah pemberian informasi. Apoteker memiliki peran penting untuk meningkatkan pelayanan informasi dan menjamin keselamatan pasien disetiap rantai perawatan. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Transition of healthcare increases the risk of chronic disease patients, therefore continuity of care (CoC) is needed for patient care. CoC measure from the patient's perspective based on experience related to continuity of information, relationships and managerial. The purpose was to study of CoC patients with type 2 diabetes mellitus (T2DM) and hypertension referral program at the Surabaya City Public Health Center and explore patient experiences in transitioning health services. The design is mixed methods. The sample was determined purposively by observe into research criteria. Data collection was using the Cuestionario Continuidad Asistencial Entre Niveles de Atencion (CCAENA) questionnaire and semi-structured interviews. Relation continuity is the highest level, where relationships with specialist are higher (95%) than general prescriber (GP) (74%). The biggest discontinuity is not being able to consult the same GP (58%). Managerial continuity related to coherence of care (91%) and accessibility (79%). The biggest managerial discontinuity is coherence between specialist and GP (85%) and accessibility when queuing at the hospital (48%). Information continuity is the lowest level (73%). The bigges","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90210383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siti Wahyuputri Megahandayani, Nur Lailiyah Yoan Mahastari, Roisa Zakia Zahra Lasmono, S. Jannah, Virmin Rahma Affifah, Hadi Barru Hakam Fajar Siddiq
Burns are skin tissue damage that occurs as a result of direct contact with a heat source. One of the natural treatments for burns is watermelon (Citrullus lanatus) rind. Watermelon rind contains citrulline, an alkaloid that plays a role in wound healing. This study aims to explore the potential of watermelon rind to become extract gel as a burn remover in male Balb/C strain mice. This research method is a true experiment that begins with the preparation of watermelon rind extract by maceration with ethanol. Furthermore, the polyphenol, flavonoid, saponin, and alkaloid content of the extract was identified through the phytochemical screening. The next stage was the preparation of a gel with three variations of extract concentrations, namely 25%, 50%, and 75% w/v. The gels were characterized by organoleptic, pH, and spreadability. The final stage tested the gel’s activity as a burn wound healing in male Balb/C strain mice. The results showed that the extract contained saponins, polyphenols, flavonoids, and alkaloids. The spreadability test results of the gel showed that all gels met the requirements. All gels had activity against burns in male Balb/C strain mice. Thus, watermelon rind extract can be used as a medicine for burns.
{"title":"The Efficacy of Watermelon (Citrullus lanatus) Rind Extract in Healing Burns in Balb/C Male Mice","authors":"Siti Wahyuputri Megahandayani, Nur Lailiyah Yoan Mahastari, Roisa Zakia Zahra Lasmono, S. Jannah, Virmin Rahma Affifah, Hadi Barru Hakam Fajar Siddiq","doi":"10.24123/mpi.v5i1.5241","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5241","url":null,"abstract":"Burns are skin tissue damage that occurs as a result of direct contact with a heat source. One of the natural treatments for burns is watermelon (Citrullus lanatus) rind. Watermelon rind contains citrulline, an alkaloid that plays a role in wound healing. This study aims to explore the potential of watermelon rind to become extract gel as a burn remover in male Balb/C strain mice. This research method is a true experiment that begins with the preparation of watermelon rind extract by maceration with ethanol. Furthermore, the polyphenol, flavonoid, saponin, and alkaloid content of the extract was identified through the phytochemical screening. The next stage was the preparation of a gel with three variations of extract concentrations, namely 25%, 50%, and 75% w/v. The gels were characterized by organoleptic, pH, and spreadability. The final stage tested the gel’s activity as a burn wound healing in male Balb/C strain mice. The results showed that the extract contained saponins, polyphenols, flavonoids, and alkaloids. The spreadability test results of the gel showed that all gels met the requirements. All gels had activity against burns in male Balb/C strain mice. Thus, watermelon rind extract can be used as a medicine for burns.","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81287836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The role of pharmacists in the implementation of pharmaceutical care has been shown to improve the outcome of therapy in hypertension patients in various countries. This study aimed to implement pharmaceutical care for hypertension patients and determine its impact on the incidence of drug-related problems (DRPs) and clinical outcomes of hypertension patients in Puskesmas Lubuk Pakam. This study used a comparative experimental method before and after the intervention of 73 hypertension patients in March-August 2021. Identification of the of DRPs was using the PCNE V9.00 standard and blood pressure values were obtained from direct examination of patients. Data were analyzed using the Wilcoxon Signed-Rank test. The results showed that the average DRPs incidence was significantly reduced after the intervention (observation, interview, and education) on the hypertension patients. The average blood pressure before intervention was 154.38 ± 16.20 mmHg and after intervention became 144.04 ± 15.94 mmHg (p value = 0.000). Based on the results of the study, it can be concluded that the application of pharmaceutical care can reduce the incidence of DRPs and improve clinical outcomes in hypertension patients in Puskesmas Lubuk Pakam.
{"title":"The Impact of Pharmaceutical Care Implementation on The Incidence of Drug-Related Problem and Clinical Outcome of Hypertension Patients at Puskesmas Lubuk Pakam in 2021","authors":"Yosi Darmirani, A. Dalimunthe, Khairunnisa, Iksen","doi":"10.24123/mpi.v5i1.5609","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5609","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000The role of pharmacists in the implementation of pharmaceutical care has been shown to improve the outcome of therapy in hypertension patients in various countries. This study aimed to implement pharmaceutical care for hypertension patients and determine its impact on the incidence of drug-related problems (DRPs) and clinical outcomes of hypertension patients in Puskesmas Lubuk Pakam. This study used a comparative experimental method before and after the intervention of 73 hypertension patients in March-August 2021. Identification of the of DRPs was using the PCNE V9.00 standard and blood pressure values were obtained from direct examination of patients. Data were analyzed using the Wilcoxon Signed-Rank test. The results showed that the average DRPs incidence was significantly reduced after the intervention (observation, interview, and education) on the hypertension patients. The average blood pressure before intervention was 154.38 ± 16.20 mmHg and after intervention became 144.04 ± 15.94 mmHg (p value = 0.000). Based on the results of the study, it can be concluded that the application of pharmaceutical care can reduce the incidence of DRPs and improve clinical outcomes in hypertension patients in Puskesmas Lubuk Pakam. \u0000 \u0000 \u0000 \u0000","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83193754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Penggunaan obat merupakan salah satu kesulitan yang dialami oleh disabilitas tunanetra dalam meningkatkan kualitas kesehatannya. Tujuan penulisan artikel ini adalah untuk mengetahui pola penggunaan obat di kalangan penyandang disabilitas tunanetra. Metode yang digunakan dalam penulisan artikel ini adalah literature review. Pencarian artikel dilakukan melalui Google Scholar dan PubMed dengan kata kunci berupa medication problems, drug use, dan visual impairments. Jumlah artikel yang berhasil dikumpulkan sebanyak 292 artikel, namun hanya empat artikel yang termasuk dalam kriteria inklusi. Hasil penelitian menunjukkan bahwa terdapat dua pola penggunaan obat utama yang digunakan oleh disabilitas tunanetra, yaitu mengandalkan bantuan orang lain dengan penglihatan normal dan menerima obat sendiri. Kedua pola ini memberikan bentuk bantuan yang berbeda bagi disabilitas tunanetra untuk dapat menggunakan obat dengan cara yang benar. The use of drugs is one of the difficulties experienced by the visually impaired in improving the quality of their health. The purpose of this review article is to find out the pattern of drug use among blind people with disabilities. The method used in writing this article is a literature review. Article searches were conducted through Google Scholar and PubMed with keywords such as medication problems, drug use, and visual impairments. The total number of articles found was 292, but only four articles met the inclusion criteria. The results showed that there were two main patterns of drug use for blind people, namely, relying on the help of others with normal vision and receiving the drug itself. These two patterns provide different forms of assistance for the visually impaired to use drugs in the right way.
这种药物的使用是盲人残疾提高健康质量的挑战之一。写这篇文章的目的是在残疾盲人的持有者当中了解药物的使用模式。本文写作中使用的方法是文学奖评论。这篇文章的搜索是通过谷歌Scholar和public进行的，其中包括治疗问题、毒品和视觉影响等关键词。成功收集了多达292篇文章的数量,但只有四篇文章中包括的内容标准。研究结果表明，盲人残疾有两种主要的药物使用方式，即依靠他人的正常视力和接受自己的药物。这两个模式提供了不同的形式帮助残疾盲人能够正确使用药物的方式。毒品的使用是一种被形象化地污染的健康品质所经历的困难之一。这篇文章的目的是找出有缺陷的盲人的毒品模式。这篇文章的方法是一篇文学评论。文章搜索是谷歌conducted通过美国和安装这样的学者和PubMed medication impairments视觉problems,毒品使用和。总共的阿蒂克勒斯号码是292，但只有四名阿蒂克勒遇到了闯入者。results那里的那里是两个玩毒品用的模式为盲people, namely, relying on The帮助其他人正常视觉和receiving《毒品的不由自主。这些二模式。不同的forms of中心# visually impaired要用毒品在正确的路。
{"title":"Pola Penggunaan Obat pada Disabilitas Tunanetra: Kajian Naratif","authors":"Dwi Resicha Adna Putri, Inge Dhamanti","doi":"10.24123/mpi.v5i1.5299","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5299","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000Penggunaan obat merupakan salah satu kesulitan yang dialami oleh disabilitas tunanetra dalam meningkatkan kualitas kesehatannya. Tujuan penulisan artikel ini adalah untuk mengetahui pola penggunaan obat di kalangan penyandang disabilitas tunanetra. Metode yang digunakan dalam penulisan artikel ini adalah literature review. Pencarian artikel dilakukan melalui Google Scholar dan PubMed dengan kata kunci berupa medication problems, drug use, dan visual impairments. Jumlah artikel yang berhasil dikumpulkan sebanyak 292 artikel, namun hanya empat artikel yang termasuk dalam kriteria inklusi. Hasil penelitian menunjukkan bahwa terdapat dua pola penggunaan obat utama yang digunakan oleh disabilitas tunanetra, yaitu mengandalkan bantuan orang lain dengan penglihatan normal dan menerima obat sendiri. Kedua pola ini memberikan bentuk bantuan yang berbeda bagi disabilitas tunanetra untuk dapat menggunakan obat dengan cara yang benar. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000The use of drugs is one of the difficulties experienced by the visually impaired in improving the quality of their health. The purpose of this review article is to find out the pattern of drug use among blind people with disabilities. The method used in writing this article is a literature review. Article searches were conducted through Google Scholar and PubMed with keywords such as medication problems, drug use, and visual impairments. The total number of articles found was 292, but only four articles met the inclusion criteria. The results showed that there were two main patterns of drug use for blind people, namely, relying on the help of others with normal vision and receiving the drug itself. These two patterns provide different forms of assistance for the visually impaired to use drugs in the right way. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"166 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77508208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Proteksi kardiovaskular penting sebagai salah satu target tatalaksana pasien diabetes mellitus (DM) tipe 2. Penghambat sodium-glukosa kotransporter 2 (SGLT2-i), obat antidiabetik relatif baru yang bekerja dengan cara memblokade transporter SGLT-2 di tubulus proksimal ginjal, diketahui memiliki fungsi proteksi kardiovaskular yang baik. Uji klinis CANVAS, EMPA-REG, DECLARE-TIMI 58, VERTIS-CV masing-masing menggunakan kanagliflozin, empagliflozin, dapagliflozin, dan ertugliflozin menunjukkan superioritas atau setara dengan plasebo. Penulisan studi literatur ini menggunakan telaah jurnal-jurnal penelitian menggunakan PubMed, SAGE, dan Google Scholar. Tujuan tinjauan ini adalah untuk merangkum konsep terkini mekanisme protektif SGLT2-i pada kejadian kardiovaskular dan penggunaannya pada pasien jantung dengan atau tanpa diabetes mellitus. SGLT2-i ditemukan menurunkan risiko hospitalisasi akibat gagal jantung (30%) dan penyakit ginjal (45%) pada pasien DM tipe 2. SGLT2-i juga lebih terjangkau dan menurunkan biaya perawatan rumah sakit. Karena masih relatif baru, penelitian-penelitian yang ada masih berfokus pada luaran klinis, mortalitas dan keamanan obat ini. Mekanisme kerja efek proteksi kardiovaskular obat ini kebanyakan masih berdasarkan uji preklinis. SGLT2-i memiliki banyak efek farmakologis yang terbukti bermanfaat dalam mencegah penyakit kardiovaskular terutama gagal jantung. Uji klinis menunjukkan manfaat kardioprotektif SGLT2-i bukan berasal dari efek antiglikemiknya, namun melalui mekanisme kompleks yang berhubungan dengan volume dan diuresis, penurunan beban jantung, metabolisme jantung, serta proteksi vaskular. Cardiovascular protection is one of the treatment targets for type 2 DM patients. Sodium- glucose cotransporter 2 inhibitor (SGLT2-i), a relatively new antidiabetic drug that works by blocking the SGLT-2 transporter in the proximal renal tubule, is not expected to have a cardiovascular protectivefunction. CANVAS, EMPA-REG, DECLARE-TIMI 58, VERTIS-CV clinical evaluation using kanagliflozin, empagliflozin, dapagliflozin, and ertugliflozin showed the superiority or equal to the placebo. This literature study uses a review of research journals using PubMed, SAGE, and Google Scholar. This review aims to summarize the current concept of the protective mechanism of SGLT2-i in cardiovascular events and its use in cardiac patients with or without diabetes mellitus. SGLT2-i was found to reduce the risk of hospitalization due to heart failure (30%) and kidney disease (45%) in type 2 DM patients. SGLT2-i is also more affordable and lowers hospitalization costs. Because it is still relatively new, the existingstudies still focus on clinical outcomes, mortality, and safety of this drug. The mechanism of action for cardiovascular protection is mostly based on preclinical trials. SGLT2-i has many pharmacological effects that have proven beneficial in preventing cardiovascular disease, especially heart failure. Clinical trials have
{"title":"Mekanisme Penghambat Sodium-Glukosa Transport Protein-2 (SGLT2-i) pada Penyakit Kardiovaskular: Sebuah Tinjauan","authors":"Benazier Marcella Besmaya, Sidhi Laksono","doi":"10.24123/mpi.v5i1.5266","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5266","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000Proteksi kardiovaskular penting sebagai salah satu target tatalaksana pasien diabetes mellitus (DM) tipe 2. Penghambat sodium-glukosa kotransporter 2 (SGLT2-i), obat antidiabetik relatif baru yang bekerja dengan cara memblokade transporter SGLT-2 di tubulus proksimal ginjal, diketahui memiliki fungsi proteksi kardiovaskular yang baik. Uji klinis CANVAS, EMPA-REG, DECLARE-TIMI 58, VERTIS-CV masing-masing menggunakan kanagliflozin, empagliflozin, dapagliflozin, dan ertugliflozin menunjukkan superioritas atau setara dengan plasebo. Penulisan studi literatur ini menggunakan telaah jurnal-jurnal penelitian menggunakan PubMed, SAGE, dan Google Scholar. Tujuan tinjauan ini adalah untuk merangkum konsep terkini mekanisme protektif SGLT2-i pada kejadian kardiovaskular dan penggunaannya pada pasien jantung dengan atau tanpa diabetes mellitus. SGLT2-i ditemukan menurunkan risiko hospitalisasi akibat gagal jantung (30%) dan penyakit ginjal (45%) pada pasien DM tipe 2. SGLT2-i juga lebih terjangkau dan menurunkan biaya perawatan rumah sakit. Karena masih relatif baru, penelitian-penelitian yang ada masih berfokus pada luaran klinis, mortalitas dan keamanan obat ini. Mekanisme kerja efek proteksi kardiovaskular obat ini kebanyakan masih berdasarkan uji preklinis. SGLT2-i memiliki banyak efek farmakologis yang terbukti bermanfaat dalam mencegah penyakit kardiovaskular terutama gagal jantung. Uji klinis menunjukkan manfaat kardioprotektif SGLT2-i bukan berasal dari efek antiglikemiknya, namun melalui mekanisme kompleks yang berhubungan dengan volume dan diuresis, penurunan beban jantung, metabolisme jantung, serta proteksi vaskular. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Cardiovascular protection is one of the treatment targets for type 2 DM patients. Sodium- glucose cotransporter 2 inhibitor (SGLT2-i), a relatively new antidiabetic drug that works by blocking the SGLT-2 transporter in the proximal renal tubule, is not expected to have a cardiovascular protectivefunction. CANVAS, EMPA-REG, DECLARE-TIMI 58, VERTIS-CV clinical evaluation using kanagliflozin, empagliflozin, dapagliflozin, and ertugliflozin showed the superiority or equal to the placebo. This literature study uses a review of research journals using PubMed, SAGE, and Google Scholar. This review aims to summarize the current concept of the protective mechanism of SGLT2-i in cardiovascular events and its use in cardiac patients with or without diabetes mellitus. SGLT2-i was found to reduce the risk of hospitalization due to heart failure (30%) and kidney disease (45%) in type 2 DM patients. SGLT2-i is also more affordable and lowers hospitalization costs. Because it is still relatively new, the existingstudies still focus on clinical outcomes, mortality, and safety of this drug. The mechanism of action for cardiovascular protection is mostly based on preclinical trials. SGLT2-i has many pharmacological effects that have proven beneficial in preventing cardiovascular disease, especially heart failure. Clinical trials have","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81882015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kerontokan rambut dapat menjadi permasalahan serius ketika dalam jumlah yang abnormal dan terjadi secara terus-menerus hingga berujung kebotakan. Kosmesetika penumbuh rambut berbahan dasar herbal dapat menjadi pilihan terapi yang tepat sebab terkait dengan keamanan penggunaan jangka panjang maupun efektivitasnya. Berbagai bentuk sediaan kosmesetika herbal penumbuh rambut telah dikembangkan yakni emulsi, gel, emulgel, krim, serum, hair tonic maupun sediaan yang dimodifikasi dengan sistem teknologi nano. Artikel review ini bertujuan untuk mengetahui sediaan kosmesetika herbal terbaik yang memenuhi spesifikasi farmasetik yang telah ditetapkan dan aktivitasnya sebagai penumbuh rambut secara in vivo. Penelitian ini berbasis systematic literature review. Berdasarkan eksplorasi literatur yang telah dilakukan dapat diketahui bahwa sediaan kosmesetika herbal terbaik dalam meningkatkan pertumbuhan rambut dan memenuhi kriteria karakteristik farmasetik adalah adalah sediaan hair tonic daun kangkung (Ipomoea aquatica Forsk.) (5%) dengan rerata peningkatan panjang rambut sebesar (2,785 ± 0,021 cm) dan bobot rambut (0,767 ± 0,057 mg/cm2) selama 21 hari. Evaluasi farmasetik hair tonic daun kangkung telah memenuhi persyaratan SNI sediaan hair tonic yang telah ditetapkan. Hair loss can be a serious problem when it is in abnormal amounts and occurs continuously leading to baldness. Herbal-based hair growth cosmeceuticals can be the right choice of therapy because it is related to the safety of long-term use and its effectiveness. Various dosage forms of herbal hair growth cosmeceuticals have been developed, namely emulsions, gels, emulgels, creams, serums, hair tonic and preparations modified with nano technology systems. This review article aims to determine the best herbal cosmeceutical preparations that meet the established pharmaceutical specifications and their activity as hair growth in vivo. This research is based on systematic literature review. Based on the literature exploration that has been carried out, it can be seen that the best herbal cosmeceutical preparation in increasing hair growth and meeting the criteria for pharmaceutical characteristics is the preparation of kale leaf hair tonic (Ipomoea aquatica Forsk.) (5%) with an average increase in hair length of (2.785 ± 0.021 cm) and hair weight (0.767 ± 0.057 mg/cm2) in 21 days. Pharmaceutical evaluation of kale leaf hair tonic has met the requirements of SNI hair tonic preparations that have been established.
{"title":"Kajian Pustaka: Sediaan Kosmesetika Penumbuh Rambut dari Berbagai Herbal Nusantara","authors":"Wayan Cintya Ganes Budastra, Teti Mariam Riandari, Ronny Martien, Retno Murwanti","doi":"10.24123/mpi.v5i1.5594","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5594","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000Kerontokan rambut dapat menjadi permasalahan serius ketika dalam jumlah yang abnormal dan terjadi secara terus-menerus hingga berujung kebotakan. Kosmesetika penumbuh rambut berbahan dasar herbal dapat menjadi pilihan terapi yang tepat sebab terkait dengan keamanan penggunaan jangka panjang maupun efektivitasnya. Berbagai bentuk sediaan kosmesetika herbal penumbuh rambut telah dikembangkan yakni emulsi, gel, emulgel, krim, serum, hair tonic maupun sediaan yang dimodifikasi dengan sistem teknologi nano. Artikel review ini bertujuan untuk mengetahui sediaan kosmesetika herbal terbaik yang memenuhi spesifikasi farmasetik yang telah ditetapkan dan aktivitasnya sebagai penumbuh rambut secara in vivo. Penelitian ini berbasis systematic literature review. Berdasarkan eksplorasi literatur yang telah dilakukan dapat diketahui bahwa sediaan kosmesetika herbal terbaik dalam meningkatkan pertumbuhan rambut dan memenuhi kriteria karakteristik farmasetik adalah adalah sediaan hair tonic daun kangkung (Ipomoea aquatica Forsk.) (5%) dengan rerata peningkatan panjang rambut sebesar (2,785 ± 0,021 cm) dan bobot rambut (0,767 ± 0,057 mg/cm2) selama 21 hari. Evaluasi farmasetik hair tonic daun kangkung telah memenuhi persyaratan SNI sediaan hair tonic yang telah ditetapkan. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Hair loss can be a serious problem when it is in abnormal amounts and occurs continuously leading to baldness. Herbal-based hair growth cosmeceuticals can be the right choice of therapy because it is related to the safety of long-term use and its effectiveness. Various dosage forms of herbal hair growth cosmeceuticals have been developed, namely emulsions, gels, emulgels, creams, serums, hair tonic and preparations modified with nano technology systems. This review article aims to determine the best herbal cosmeceutical preparations that meet the established pharmaceutical specifications and their activity as hair growth in vivo. This research is based on systematic literature review. Based on the literature exploration that has been carried out, it can be seen that the best herbal cosmeceutical preparation in increasing hair growth and meeting the criteria for pharmaceutical characteristics is the preparation of kale leaf hair tonic (Ipomoea aquatica Forsk.) (5%) with an average increase in hair length of (2.785 ± 0.021 cm) and hair weight (0.767 ± 0.057 mg/cm2) in 21 days. Pharmaceutical evaluation of kale leaf hair tonic has met the requirements of SNI hair tonic preparations that have been established. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75445736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Penyakit kardiovaskular adalah salah satu penyebab kematian terbesar, baik di Indonesia dan di dunia. Statin telah terbukti efektif untuk pencegahan primer dan sekunder penyakit kardiovaskular. Akan tetapi, beberapa penelitian menunjukkan penggunaan statin untuk indikasi tersebut masih belum optimal. Tujuan penelitian ini adalah untuk mengidentifikasi factor-faktor yang mempengahruhi ketidaksesuaian penggunaan statin pada pengguna statin pertama kali (first-user). Penelitian ini adalah penelitian retrospektif yang melibatkan 102 orang pasien yang berkunjung ke Apotek UBAYA. Hasil penelitian menunjukkan bahwa 56,9% pasien yang terlibat adalah perempuan dan 42,2% pasien berada pada kelompok usia 51-60 tahun. Berdasarkan perhitungan tingkat risiko kardiovaskular 10-tahun, sebesar 24.5% pasien mengalami ketidaksesuaian penggunaan statin. Ketidaksesuaian penggunaan statin ini khususnya ditemukan pada kelompok risiko tinggi (51,7%) dan kelompok risiko sangat tinggi (23,7%). Faktor-faktor yang mempengaruhi ketidaksesuaian penggunaan statin adalah memiliki diabetes mellitus (adjusted odds ratio, aOR 10,61; 95% CI 2,84-39,68; p = 0,00) dan memiliki asuransi kesehatan (aOR 4,96; 95% CI 1,49-16,48; p = 0,01). Cardiovascular disease (CVD) is one of the leading causes of deaths both in Indonesia and in the world. Statins have been proven to be effective for primary and secondary prevention of CVDs. However, several studies show that the use of statins for those indications are still sub optimal. The aimof this study was to identify factors influencing inappropriateness use of statins in the first-user statins. This was a retrospective study involving 102 patients visited the UBAYA Pharmacy. The result of the study showed that 56.9% of the patients involved were women and 42.2% of the patients were in the age group of 51-60 years. Based on the 10-year cardiovascular risk estimation, as many as 24.5% of the patients inappropriately used statins. The inappropriateness use of statins was especially found in the high-risk group (51.7%) and in the very high-risk group (23.7%). Factors influencing the inappropriateness use of statins in the first-user statins were having diabetes mellitus (adjusted odds ratio, aOR 10.61; 95% CI 2.84-39.68; p = 0.00) and having health insurance (aOR 4.96; 95% CI 1.49-16.48; p = 0.01).
{"title":"Faktor - Faktor yang Mempengaruhi Ketidaksesuaian Pemberian Statin pada First-user Statins di Apotek UBAYA","authors":"Dody Mulia Yaputra, Yosi Irawati Wibowo, Lisa Aditama, Cecilia Brata, Sylvi Irawati","doi":"10.24123/mpi.v5i1.5494","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5494","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000Penyakit kardiovaskular adalah salah satu penyebab kematian terbesar, baik di Indonesia dan di dunia. Statin telah terbukti efektif untuk pencegahan primer dan sekunder penyakit kardiovaskular. Akan tetapi, beberapa penelitian menunjukkan penggunaan statin untuk indikasi tersebut masih belum optimal. Tujuan penelitian ini adalah untuk mengidentifikasi factor-faktor yang mempengahruhi ketidaksesuaian penggunaan statin pada pengguna statin pertama kali (first-user). Penelitian ini adalah penelitian retrospektif yang melibatkan 102 orang pasien yang berkunjung ke Apotek UBAYA. Hasil penelitian menunjukkan bahwa 56,9% pasien yang terlibat adalah perempuan dan 42,2% pasien berada pada kelompok usia 51-60 tahun. Berdasarkan perhitungan tingkat risiko kardiovaskular 10-tahun, sebesar 24.5% pasien mengalami ketidaksesuaian penggunaan statin. Ketidaksesuaian penggunaan statin ini khususnya ditemukan pada kelompok risiko tinggi (51,7%) dan kelompok risiko sangat tinggi (23,7%). Faktor-faktor yang mempengaruhi ketidaksesuaian penggunaan statin adalah memiliki diabetes mellitus (adjusted odds ratio, aOR 10,61; 95% CI 2,84-39,68; p = 0,00) dan memiliki asuransi kesehatan (aOR 4,96; 95% CI 1,49-16,48; p = 0,01). \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Cardiovascular disease (CVD) is one of the leading causes of deaths both in Indonesia and in the world. Statins have been proven to be effective for primary and secondary prevention of CVDs. However, several studies show that the use of statins for those indications are still sub optimal. The aimof this study was to identify factors influencing inappropriateness use of statins in the first-user statins. This was a retrospective study involving 102 patients visited the UBAYA Pharmacy. The result of the study showed that 56.9% of the patients involved were women and 42.2% of the patients were in the age group of 51-60 years. Based on the 10-year cardiovascular risk estimation, as many as 24.5% of the patients inappropriately used statins. The inappropriateness use of statins was especially found in the high-risk group (51.7%) and in the very high-risk group (23.7%). Factors influencing the inappropriateness use of statins in the first-user statins were having diabetes mellitus (adjusted odds ratio, aOR 10.61; 95% CI 2.84-39.68; p = 0.00) and having health insurance (aOR 4.96; 95% CI 1.49-16.48; p = 0.01). \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75646586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ni Putu Ermi Hikmawanti, Agustin Yumita, E. Hanani, Shafira Faradisa, Siti Fatimah Az-zahra, Shafna Raudlatul Ashfiya
Tiga spesies dari genus Syzygium, seperti jambu air (Syzygium aqueum (Burm.f.) Alston), jambu bol (Syzygium malaccense (L.) Merr. & L.M. Perry), dan jambu semarang (Syzygium samarangense (Blume) Merr. & L. M. Perry), telah dimanfaatkan daunnya dalam pengobatan tradisional karena kandungan polifenolnya. Penelitian ini bertujuan untuk mempelajari anatomi jaringan, mikroskopis, kadar senyawa fenol, flavonoid, dan tanin ekstrak etanol daun dari tiga jenis jambu tersebut. Daun jambu biji (Psidium guajava) digunakan sebagai pembanding. Anatomi jaringan daun dan identifikasi mikroskopis dilakukan menggunakan mikroskop. Penentuan kadar senyawa pada ekstrak etanol 70% ditentukan dengan metode kolorimetri yang absorbansinya diukur pada spektrofotometer UV- Vis. Anatomi jaringan daun dan fragmen pengenal secara mikroskopis ada kemiripan pada ketiga jenis daun jambu genus Syzygium. Secara statistik, ada perbedaan signifikan antara kadar fenol, flavonoid, dan tanin pada ekstrak etanol 70% daun jambu air, daun jambu bol, dan daun jambu semarang dibandingkan dengan ekstrak etanol 70% daun jambu biji. Daun jambu air merupakan spesiesterpilih dari genus Syzygium yang diuji pada penelitian ini dengan kandungan polifenol yang tinggi. Leaves of three guava species of the genus Syzygium, such as water apple/jambu air (Syzygium aqueum (Burm.f.) Alston), malay apple/jambu bol (Syzygium malaccense (L.) Merr. & L.M. Perry), and wax apple/jambu Semarang (Syzygium samarangense (Blume) Merr. & L. M. Perry), have been used in traditional medicine because of its polyphenol content. This study aims to investigate the anatomy of leaf tissues, powder microscopical characteristic, and total phenolic, flavonoids, and tannins content in the ethanol extract of the leaves of the three types of selected guava species of the genus Syzygium. Guava leaves (Psidium guajava) were used as a comparison. Leaf tissue anatomy and microscopic identification were carried out using a microscope. Determination of the polyphenol content in 70% ethanol extract was determined by the colorimetric method in which the absorbance was measured on a UV-Vis spectrophotometer. Leaf tissue anatomy and microscopic recognition fragments are similar in the three types of Syzygium guava leaves. Statistically, there were significant differences between the total phenols, flavonoids, and tannins content in the 70% ethanol extract of water apple, Malay apple, and wax apple compared to the 70% ethanol extract of guava leaves. Water apple leaves are selectedspecies from the genus Syzygium tested in this study with high polyphenol content.
Syzygium属的三种，如番石榴(Syzygium aqueum)。奥尔斯顿，番石榴(Syzygium malaccense, L)。默尔。和L. Perry，和jambu semarang (Syzygium samarangense (Blume) Merr。& L. Perry)，由于其多酚含量，在传统医学中利用了叶子。这项研究的目标是研究组织解剖、微观、苯酚、类黄烷和由三种番石榴组成的叶子乙醇的含量。番石榴叶(学名psiajava)用来做比较。叶组织解剖和微观识别是使用显微镜进行的。乙醇提取物70%的化合物测定是用紫外线光谱仪测量的计量方法确定的。从统计数据上看，苯酚、类黄酮和乙醇提取物的含量与70%的水番石榴叶、番石榴叶和三叶番石榴提取物存在显著差异。番石榴叶是一种特殊的Syzygium属，在这项研究中检测到高复酚含量。这是Syzygium属的三个guava物种，就像水苹果/番石榴水(Syzygium aquium)。Alston，马来苹果/番石榴(Syzygium malaccense, L)。默尔。佩里，上蜡苹果/番石榴三宝垄(Syzygium samarangense (Blume) Merr。丹·佩里，因为它的多苯酚内涵，一直用于传统医学。这一研究是对叶组织、微scoscoistic、和总酚、黄麻黄素和坦内内的果实进行研究的。Guava叶(学名psiajava)曾被用作comparison。解剖叶组织和微探针被用微探针标记出来。70%的乙醇满足的多酚的决心是由颜色的方法论在吸收器对摄谱仪的影响下确定的。解剖叶和微scopic碎片的分裂类似于Syzygium guava叶子的三种类型。从数据上看，在70%的乙醇、黄麻黄素和鞣质中存在显著差异。水苹果从Syzygium属中筛选物种，用于高聚醇的研究。
{"title":"Anatomi Jaringan, Identifikasi Mikroskopis, serta Kadar Polifenol Ekstrak Etanol Daun dari Tiga Jenis Jambu Genus Syzygium","authors":"Ni Putu Ermi Hikmawanti, Agustin Yumita, E. Hanani, Shafira Faradisa, Siti Fatimah Az-zahra, Shafna Raudlatul Ashfiya","doi":"10.24123/mpi.v5i1.5311","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5311","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000Tiga spesies dari genus Syzygium, seperti jambu air (Syzygium aqueum (Burm.f.) Alston), jambu bol (Syzygium malaccense (L.) Merr. & L.M. Perry), dan jambu semarang (Syzygium samarangense (Blume) Merr. & L. M. Perry), telah dimanfaatkan daunnya dalam pengobatan tradisional karena kandungan polifenolnya. Penelitian ini bertujuan untuk mempelajari anatomi jaringan, mikroskopis, kadar senyawa fenol, flavonoid, dan tanin ekstrak etanol daun dari tiga jenis jambu tersebut. Daun jambu biji (Psidium guajava) digunakan sebagai pembanding. Anatomi jaringan daun dan identifikasi mikroskopis dilakukan menggunakan mikroskop. Penentuan kadar senyawa pada ekstrak etanol 70% ditentukan dengan metode kolorimetri yang absorbansinya diukur pada spektrofotometer UV- Vis. Anatomi jaringan daun dan fragmen pengenal secara mikroskopis ada kemiripan pada ketiga jenis daun jambu genus Syzygium. Secara statistik, ada perbedaan signifikan antara kadar fenol, flavonoid, dan tanin pada ekstrak etanol 70% daun jambu air, daun jambu bol, dan daun jambu semarang dibandingkan dengan ekstrak etanol 70% daun jambu biji. Daun jambu air merupakan spesiesterpilih dari genus Syzygium yang diuji pada penelitian ini dengan kandungan polifenol yang tinggi. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Leaves of three guava species of the genus Syzygium, such as water apple/jambu air (Syzygium aqueum (Burm.f.) Alston), malay apple/jambu bol (Syzygium malaccense (L.) Merr. & L.M. Perry), and wax apple/jambu Semarang (Syzygium samarangense (Blume) Merr. & L. M. Perry), have been used in traditional medicine because of its polyphenol content. This study aims to investigate the anatomy of leaf tissues, powder microscopical characteristic, and total phenolic, flavonoids, and tannins content in the ethanol extract of the leaves of the three types of selected guava species of the genus Syzygium. Guava leaves (Psidium guajava) were used as a comparison. Leaf tissue anatomy and microscopic identification were carried out using a microscope. Determination of the polyphenol content in 70% ethanol extract was determined by the colorimetric method in which the absorbance was measured on a UV-Vis spectrophotometer. Leaf tissue anatomy and microscopic recognition fragments are similar in the three types of Syzygium guava leaves. Statistically, there were significant differences between the total phenols, flavonoids, and tannins content in the 70% ethanol extract of water apple, Malay apple, and wax apple compared to the 70% ethanol extract of guava leaves. Water apple leaves are selectedspecies from the genus Syzygium tested in this study with high polyphenol content. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85736721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lina Rahmawati Rizkuloh, Salsabila Adlina, Anna Yuliana
Daun jambu biji (Psidium guajava L.) merupakan salah satu tanaman yang berkhasiat, karena mengandung metabolit sekunder saponin, tanin, flavonoid, serta alkaloid. Senyawa-senyawa tersebut memiliki sifat antibakteri. Kandungan antibakteri pada daun jambu biji ini menjadi dasarpengembangan sediaan dalam bentuk salep yang berkhasiat sebagai antibakteri dengan memvariasikan salah satu bahan sebagai penstabil yaitu dinatrium EDTA. Tujuan dari penelitian ini adalah mengetahui pengaruh konsentrasi dinatrium EDTA tehadap stabilitas fisika sediaan salep ekstraketanol daun jambu biji (Psidium guajva L.). Dalam penelitian ini dibuat 3 formula dengan variasi konsentrasi dinatrium EDTA yaitu F1 (0,05%); F2 (0,08%) serta F3 (0,10%). Evaluasi stabilitas fisik sediaan salep dilakukan selama 12 hari (6 siklus), meliputi uji organoleptik, uji homogenitas, uji pH, uji daya lekat, uji daya sebar dan uji stabilitas. Hasil pengamatan organoleptik selama cycling test menunjukan adanya perubahan warna pada sediaan yaitu pada siklus ke 5 dan 6. Selain itu, dengan bertambahnya konsentrasi dinatrium EDTA berpengaruh terhadap pH. Semakin tinggi konsentrasi dinatrium EDTA maka semakin kecil pH dan berpengaruh pada stabilitas fisika sediaan. Hasil menunjukan bahwa sediaan yang stabil dan memenuhi syarat yaitu formula 3 dengan konsentrasi dinatrium EDTA 0,10 %. Guava leaves (Psidium guajava L.) is one of the efficacious plants, because it contains secondary metabolites of saponins, tannins, flavonoids, and alkaloids; where these compounds have antibacterial properties. With the presence of antibacterial content in guava leaves, a preparation was made in the form of an antibacterial ointment by varying one of the ingredients as a stabilizer, namely disodium EDTA. The purpose of this study was to determine the effect of disodium EDTA concentration on the physical stability of the ethanol extract ointment of guava leaves (Psidium guajva L.). In this study, 3 formulas were prepared with variations in the concentration of disodium EDTA, namely F1 (0.05%); F2 (0.08%) and F3 (0.10%), respectively. Evaluation of the physical stability of the ointment was carried out for 12 days (6 cycles), including organoleptic tests, homogeneity tests, pH tests, adhesion tests, spreadability tests and stability tests. The results of organoleptic observations during the cycling test showed that there was a change in the color of the preparation in the 5th and 6th cycles. In addition, increasing the disodium EDTA concentration affected the pH, where the higher the disodium EDTA concentration, the lower the pH and affected the physical stability of the preparation. The results showed that the preparation that met the requirements for ointment stability was formula 3 with a concentration of 0.10% disodium EDTA.
{"title":"Pengaruh Variasi Konsentrasi Dinatrium EDTA Terhadap Stabilitas Fisika dan pH Sediaan Salep Ekstrak Etanol Daun Jambu Biji (Psidium guajava L.)","authors":"Lina Rahmawati Rizkuloh, Salsabila Adlina, Anna Yuliana","doi":"10.24123/mpi.v5i1.5539","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5539","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Daun jambu biji (Psidium guajava L.) merupakan salah satu tanaman yang berkhasiat, karena mengandung metabolit sekunder saponin, tanin, flavonoid, serta alkaloid. Senyawa-senyawa tersebut memiliki sifat antibakteri. Kandungan antibakteri pada daun jambu biji ini menjadi dasarpengembangan sediaan dalam bentuk salep yang berkhasiat sebagai antibakteri dengan memvariasikan salah satu bahan sebagai penstabil yaitu dinatrium EDTA. Tujuan dari penelitian ini adalah mengetahui pengaruh konsentrasi dinatrium EDTA tehadap stabilitas fisika sediaan salep ekstraketanol daun jambu biji (Psidium guajva L.). Dalam penelitian ini dibuat 3 formula dengan variasi konsentrasi dinatrium EDTA yaitu F1 (0,05%); F2 (0,08%) serta F3 (0,10%). Evaluasi stabilitas fisik sediaan salep dilakukan selama 12 hari (6 siklus), meliputi uji organoleptik, uji homogenitas, uji pH, uji daya lekat, uji daya sebar dan uji stabilitas. Hasil pengamatan organoleptik selama cycling test menunjukan adanya perubahan warna pada sediaan yaitu pada siklus ke 5 dan 6. Selain itu, dengan bertambahnya konsentrasi dinatrium EDTA berpengaruh terhadap pH. Semakin tinggi konsentrasi dinatrium EDTA maka semakin kecil pH dan berpengaruh pada stabilitas fisika sediaan. Hasil menunjukan bahwa sediaan yang stabil dan memenuhi syarat yaitu formula 3 dengan konsentrasi dinatrium EDTA 0,10 %. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Guava leaves (Psidium guajava L.) is one of the efficacious plants, because it contains secondary metabolites of saponins, tannins, flavonoids, and alkaloids; where these compounds have antibacterial properties. With the presence of antibacterial content in guava leaves, a preparation was made in the form of an antibacterial ointment by varying one of the ingredients as a stabilizer, namely disodium EDTA. The purpose of this study was to determine the effect of disodium EDTA concentration on the physical stability of the ethanol extract ointment of guava leaves (Psidium guajva L.). In this study, 3 formulas were prepared with variations in the concentration of disodium EDTA, namely F1 (0.05%); F2 (0.08%) and F3 (0.10%), respectively. Evaluation of the physical stability of the ointment was carried out for 12 days (6 cycles), including organoleptic tests, homogeneity tests, pH tests, adhesion tests, spreadability tests and stability tests. The results of organoleptic observations during the cycling test showed that there was a change in the color of the preparation in the 5th and 6th cycles. In addition, increasing the disodium EDTA concentration affected the pH, where the higher the disodium EDTA concentration, the lower the pH and affected the physical stability of the preparation. The results showed that the preparation that met the requirements for ointment stability was formula 3 with a concentration of 0.10% disodium EDTA. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83640339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gangguan kecemasan (ansietas) adalah kondisi medis yang dikarakterisasi oleh adanya perasaan cemas akan sesuatu yang bersifat irasional. Beberapa gangguan kecemasan yang umum terjadi adalah gangguan kecemasan tergeneralisasi, gangguan panik, fobia, gangguan kecemasan social, dan post-traumatic stress disorder (PTSD). Kulit pisang Cavendish (Musa acuminata Cavendish) mengandung berbagai senyawa bioaktif, seperti flavonoid gatokatekin yang diduga memiliki sifat antiansietas. Penelitian ini bertujuan untuk mengetahui efek antiansietas ekstrak etanol kulit pisang Cavendish (Musa acuminata Cavendish) dengan berbagai dosis. Penelitian eksperimen dilakukan dengan post-test only control group design. Tiga puluh mencit putih Swiss Webster (Mus musculus) jantan dibagi menjadi 5 kelompok secara acak: kelompok kontrol (CMC Na 1%), kelompok obat standar (diazepam 0,13 mg/kgBB), dan tiga kelompok ekstrak kulit pisang Cavendish (EEKPC) dengan dosis 200 mg/kg, 400 mg/kg dan 800 mg/kg. Aktivitas antiansietas dievaluasi dengan Elevated plus maze (EPM), light dark test (LDT), dan open field test (OFT). Hasil penelitian menunjukkan bahwa EEKPC 200 mg/kg secara signifikan meningkatkan durasi hewan uji di tangan terbuka pada uji EPM (p<0,05) dibandingkan dengan kelompok kontrol. Dosis EEKPC 200 mg/ kg juga mampu meningkatkan durasi di area terang secara signifikan pada uji LDT dibandingkan dengan kelompok kontrol (p<0,05). Pada OFT, dosis EKPC 200 mg/kg secara signifikan meningkatkan durasi di area tengah (p<0,05) dibandingkan dengan kelompok kontrol. Hasil penelitian ini mendukung pengembangan kulit pisang Cavendish (Musa acuminata Cavendish) sebagai terapi komplementer untuk gangguan kecemasan. Anxiety disorder is a mental health condition characterized by feelings of anxiety and irrational fear of something. These disorders include generalized anxiety disorder, panic disorder, phobias, social anxiety disorder, and post-traumatic stress disorder. Cavendish banana peel (Musa acuminata Cavendish) contains various bioactive compounds, including flavonoid galocatechin which is proposed to have antianxiety properties. This study was aimed to determine the antianxiety effect of various doses of 80% ethanolic extract of Cavendish banana peel (Musa acuminata Cavendish). The experimental study was conducted with a post-test only control group design. Thirty male Swiss Webster white mice (Mus musculus) were divided randomly into 5 groups: control group (CMC Na 1%), the standard drug group (diazepam 0.13 mg/kgBW), and three groups of Cavendish banana peel extract (EEKPC) at doses of 200 mg/kg, 400 mg/kg and 800 mg/kg. Antianxiety activity was evaluated by elevated plus maze (EPM), light dark test (LDT), and open field test (OFT). The results showed that EEKPC 200 mg/kg significantly increased the duration of the test animals in the open arms in the EPM test (p<0.05) compared to the control group. EEKPC dose of 200 mg/kg was also able to significantly increas
焦虑障碍(ansietas)是一种被非理性的焦虑所定义的疾病。常见的焦虑障碍包括泛化焦虑障碍、恐慌症、恐惧症、社交焦虑障碍和创伤后应激障碍。卡文迪许香蕉皮(摩西卡文迪许acuminata)含有多种生物活性化合物，如类黄酮，被认为具有抗扭性。本研究的目的是研究多剂量香蕉皮乙醇的抗酸剂对卡文迪许香蕉皮的影响。实验研究是在post- only control group design进行的。30毫克的瑞士韦伯斯特(穆斯库勒)被随机分为5组:控制小组(CMC Na 1%)、标准药物(diazepam 0.13 mg/kgBB)和三组香蕉萃取物(EEKPC)，剂量为200毫克/kg、400毫克/kg和800毫克/kg。antiansietas的活动被评为Elevated plus maze (EPM)、light dark test (LDT)和开放场测试(OFT)。研究结果表明，EEKPC 200 mg/kg与控制组相比，在EPM (p< 0.05)的手动试验动物的持续时间显著增加。EEKPC剂量200 mg/ kg也能显著增加LDT测试中光区域的持续时间，与控制组(p< 0.05)进行比较。在OFT中，expc剂量为200毫克/公斤，与控制组相比，平均长短(p< 0.05)。这项研究支持卡文迪许香蕉皮(摩西卡文迪许acuminata Cavendish)作为一种补充焦虑症的疗法的发展。焦虑障碍是一种心理健康状况，由对某物的焦虑和非理性恐惧的感觉产生。这些疾病导致了焦虑症、恐慌症、恐惧症、社会焦虑障碍和创伤后应激障碍。卡文迪许香蕉皮(摩西·卡文迪许这项研究可以确定80%的卡文迪许排他性毒品的不同效果。实验研究是由一个只有事后控制的小组设计设计设计的。第三个男人进入5组:控制小组(CMC Na 1%)，标准毒品小组(diazepam banana /kgBW)，还有三组卡文迪什香蕉extract (eek直接)，分别在200 mg/kg、400 mg/kg和800 mg/kg之间。反焦虑活动是由元素加上迷宫、光暗测试和开放场测试来评估的。结果显示，在EPM测试(p<0.05)中，动物测试的结果显著增加了。200毫克/公斤的EEKPC剂量也可能显著增加在LDT测试控制组(p<0.05)的对光区域的duration。在OFT中，ecpc花费200毫克/kg的急剧增加(p<0.05)被用于控制小组。这项研究支持卡文迪许香蕉皮的发展，作为对焦虑障碍的完整治疗。
{"title":"Aktivitas Antiansietas Ekstrak Etanol Kulit Buah Pisang Cavendish (Musa acuminata Cavendish): Studi In Vivo dengan Metode Elevated Plus Maze (EPM), Light Dark Test (LDT), and Open Field Test (OFT)","authors":"Widyastiwi, Yoga Adi Restu Muzaki, M. Roseno","doi":"10.24123/mpi.v5i1.5576","DOIUrl":"https://doi.org/10.24123/mpi.v5i1.5576","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000Gangguan kecemasan (ansietas) adalah kondisi medis yang dikarakterisasi oleh adanya perasaan cemas akan sesuatu yang bersifat irasional. Beberapa gangguan kecemasan yang umum terjadi adalah gangguan kecemasan tergeneralisasi, gangguan panik, fobia, gangguan kecemasan social, dan post-traumatic stress disorder (PTSD). Kulit pisang Cavendish (Musa acuminata Cavendish) mengandung berbagai senyawa bioaktif, seperti flavonoid gatokatekin yang diduga memiliki sifat antiansietas. Penelitian ini bertujuan untuk mengetahui efek antiansietas ekstrak etanol kulit pisang Cavendish (Musa acuminata Cavendish) dengan berbagai dosis. Penelitian eksperimen dilakukan dengan post-test only control group design. Tiga puluh mencit putih Swiss Webster (Mus musculus) jantan dibagi menjadi 5 kelompok secara acak: kelompok kontrol (CMC Na 1%), kelompok obat standar (diazepam 0,13 mg/kgBB), dan tiga kelompok ekstrak kulit pisang Cavendish (EEKPC) dengan dosis 200 mg/kg, 400 mg/kg dan 800 mg/kg. Aktivitas antiansietas dievaluasi dengan Elevated plus maze (EPM), light dark test (LDT), dan open field test (OFT). Hasil penelitian menunjukkan bahwa EEKPC 200 mg/kg secara signifikan meningkatkan durasi hewan uji di tangan terbuka pada uji EPM (p<0,05) dibandingkan dengan kelompok kontrol. Dosis EEKPC 200 mg/ kg juga mampu meningkatkan durasi di area terang secara signifikan pada uji LDT dibandingkan dengan kelompok kontrol (p<0,05). Pada OFT, dosis EKPC 200 mg/kg secara signifikan meningkatkan durasi di area tengah (p<0,05) dibandingkan dengan kelompok kontrol. Hasil penelitian ini mendukung pengembangan kulit pisang Cavendish (Musa acuminata Cavendish) sebagai terapi komplementer untuk gangguan kecemasan. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Anxiety disorder is a mental health condition characterized by feelings of anxiety and irrational fear of something. These disorders include generalized anxiety disorder, panic disorder, phobias, social anxiety disorder, and post-traumatic stress disorder. Cavendish banana peel (Musa acuminata Cavendish) contains various bioactive compounds, including flavonoid galocatechin which is proposed to have antianxiety properties. This study was aimed to determine the antianxiety effect of various doses of 80% ethanolic extract of Cavendish banana peel (Musa acuminata Cavendish). The experimental study was conducted with a post-test only control group design. Thirty male Swiss Webster white mice (Mus musculus) were divided randomly into 5 groups: control group (CMC Na 1%), the standard drug group (diazepam 0.13 mg/kgBW), and three groups of Cavendish banana peel extract (EEKPC) at doses of 200 mg/kg, 400 mg/kg and 800 mg/kg. Antianxiety activity was evaluated by elevated plus maze (EPM), light dark test (LDT), and open field test (OFT). The results showed that EEKPC 200 mg/kg significantly increased the duration of the test animals in the open arms in the EPM test (p<0.05) compared to the control group. EEKPC dose of 200 mg/kg was also able to significantly increas","PeriodicalId":18807,"journal":{"name":"MPI (Media Pharmaceutica Indonesiana)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72729878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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