X. Zhou, Chuan‐Yu Zhang, Song Pu, Kai Yang, Zhe Shi
In this paper, the tailings produced by non-ferrous metallurgy were magnetically separated to obtain magnetic separation tailings. The sintering performance of magnetic separation tailings was studied by sintering cup experiment platform. In the research process, the differences in sintering process of different magnetic separation tailings were compared, including vertical sintering speed, sintering coefficient, drum strength, finished product rate, end point temperature and other sintering indexes. At the same time, the obtained sinter was subjected to chemical analysis to obtain its specific components. The influence of magnetic separation tailings with different contents on sintering was obtained by ore blending. The experimental results showed that the copper tailings are not sintered and the yield is only 0%. Tin tailings are not sintered and the yield is only 22.30%. The aluminum tailings can be sintered into lumps with a yield of only 57.10%. As the proportion of magnetic separation tailings increases, the vertical sintering speed decreases, the sintering utilization coefficient decreases, the sinter drum index decreases, the yield decreases, the sinter grade decreases, and the SiO2, S and P contents increase. In actual production, the proportion of magnetic separation tailings should be controlled below 10%.
{"title":"Sintering Properties of Magnetic Separation Nonferrous Metallurgical Tailings","authors":"X. Zhou, Chuan‐Yu Zhang, Song Pu, Kai Yang, Zhe Shi","doi":"10.1166/NNL.2020.3188","DOIUrl":"https://doi.org/10.1166/NNL.2020.3188","url":null,"abstract":"In this paper, the tailings produced by non-ferrous metallurgy were magnetically separated to obtain magnetic separation tailings. The sintering performance of magnetic separation tailings was studied by sintering cup experiment platform. In the research process, the differences in\u0000 sintering process of different magnetic separation tailings were compared, including vertical sintering speed, sintering coefficient, drum strength, finished product rate, end point temperature and other sintering indexes. At the same time, the obtained sinter was subjected to chemical analysis\u0000 to obtain its specific components. The influence of magnetic separation tailings with different contents on sintering was obtained by ore blending. The experimental results showed that the copper tailings are not sintered and the yield is only 0%. Tin tailings are not sintered and the yield\u0000 is only 22.30%. The aluminum tailings can be sintered into lumps with a yield of only 57.10%. As the proportion of magnetic separation tailings increases, the vertical sintering speed decreases, the sintering utilization coefficient decreases, the sinter drum index decreases, the yield decreases,\u0000 the sinter grade decreases, and the SiO2, S and P contents increase. In actual production, the proportion of magnetic separation tailings should be controlled below 10%.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"885-889"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43572290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this work, we harnessed the good biocompatibility and biodegradability of nanoparticles by constructing a nanocomposite based on hydroxyapatite/carboxymethyl chitosan (nHAp/CMCS NPs) and using it to heal bone fractures. We used Mesenchymal stem cells to study osteogenesis and bone healing. The scanning electron microscope (SEM) image of the nHAp/CMCS NPs shows that its average particle size is 200±0.53 nm. In vitro experiments show that the nanomaterial has excellent biocompatibility, no cytotoxicity, and significantly promotes the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs). In vivo experiments show that nHAp/CMCS NPs have obvious growth-promoting and healing effects on rat bone fractures. Therefore, hydroxyapatite-based nanocomposites provide new treatment strategies for bone formation by BMSCs and fracture healing.
{"title":"Preparation of a Carboxymethyl Chitosan Nanocomposite and Its Application in Fracture Repair","authors":"Juren He, Liang Yang, Xiaojie Song, Yangang Gao","doi":"10.1166/NNL.2020.3193","DOIUrl":"https://doi.org/10.1166/NNL.2020.3193","url":null,"abstract":"In this work, we harnessed the good biocompatibility and biodegradability of nanoparticles by constructing a nanocomposite based on hydroxyapatite/carboxymethyl chitosan (nHAp/CMCS NPs) and using it to heal bone fractures. We used Mesenchymal stem cells to study osteogenesis and bone\u0000 healing. The scanning electron microscope (SEM) image of the nHAp/CMCS NPs shows that its average particle size is 200±0.53 nm. In vitro experiments show that the nanomaterial has excellent biocompatibility, no cytotoxicity, and significantly promotes the proliferation and osteogenic\u0000 differentiation of rat bone marrow mesenchymal stem cells (BMSCs). In vivo experiments show that nHAp/CMCS NPs have obvious growth-promoting and healing effects on rat bone fractures. Therefore, hydroxyapatite-based nanocomposites provide new treatment strategies for bone formation\u0000 by BMSCs and fracture healing.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"928-933"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45829969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burns are the most common clinical disease in daily life. Burn wounds are vulnerable to bacterial infection due to factors such as edema, hypoxia, and ischemia. However, traditional antibacterial supplements do not achieve satisfactory nursing results. Here, we use chitosan as a carrier by introducing silver nanoparticles (AgNPs) and recombinant human epidermal growth factor (rhEGF) together. We have constructed a new type of high moisture retention, high oxygen permeability, high-efficiency chitosan-nanosilver@recombinant human epidermal growth factor (CSAgNPs@ rhEGF) antibacterial hydrogel dressing. The clinical trials showed that the antibacterial effect of CS-AgNPs@rhEGF hydrogel dressings against Pseudomonas aeruginosa (Pa.) and Staphylococcus epidermidis (Se.) was significantly better than that of petroleum jelly and 1% silver sulfadiazine (1%-SSD). In addition, rhEGF promoted tissue cell proliferation and repair. Thus, the CS-AgNPs@rhEGF hydrogel dressing can significantly improve the wound healing rate and healing time in patients with severe burns compared with traditional dressings. Thus, CS-AgNPs@rhEGF hydrogel dressing is expected to provide a new choice for clinical burn patients to prevent wound infection and tissue repair, and has a broad prospect in burn wound healing.
{"title":"Chitosan-Based Composite Nanosilver Gel Application in Nursing Care of Intensive Care Unit Patients with Severe Burns","authors":"Ningning Rong, Ruyan Yang, Yongzan Lu","doi":"10.1166/NNL.2020.3192","DOIUrl":"https://doi.org/10.1166/NNL.2020.3192","url":null,"abstract":"Burns are the most common clinical disease in daily life. Burn wounds are vulnerable to bacterial infection due to factors such as edema, hypoxia, and ischemia. However, traditional antibacterial supplements do not achieve satisfactory nursing results. Here, we use chitosan as a carrier\u0000 by introducing silver nanoparticles (AgNPs) and recombinant human epidermal growth factor (rhEGF) together. We have constructed a new type of high moisture retention, high oxygen permeability, high-efficiency chitosan-nanosilver@recombinant human epidermal growth factor (CSAgNPs@ rhEGF) antibacterial\u0000 hydrogel dressing. The clinical trials showed that the antibacterial effect of CS-AgNPs@rhEGF hydrogel dressings against Pseudomonas aeruginosa (Pa.) and Staphylococcus epidermidis (Se.) was significantly better than that of petroleum jelly and 1% silver sulfadiazine\u0000 (1%-SSD). In addition, rhEGF promoted tissue cell proliferation and repair. Thus, the CS-AgNPs@rhEGF hydrogel dressing can significantly improve the wound healing rate and healing time in patients with severe burns compared with traditional dressings. Thus, CS-AgNPs@rhEGF hydrogel dressing\u0000 is expected to provide a new choice for clinical burn patients to prevent wound infection and tissue repair, and has a broad prospect in burn wound healing.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"939-945"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48752595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To efficiently treat landfill leachate, we prepared a new integrated submerged membrane bioreactor (SMBR) and oxidation technology. Our results, under organic loading rates of 2.0–2.3 kg COD/(m3 ·d), showed that through SMBR we can acquire removal efficiencies of 91.2% and 87.3% for ammonia and chemical oxygen demand (COD), respectively. A Ti/RuO2–IrO2 anode and stainless-steel cathode combination was engaged to carry out electrochemical oxidation of SMBR permeate. Ammonia and COD were removed after 3 h electrochemical oxidation (at 40 mA/cm2 current density), and achieved 93.5% and 66.9% removal efficiency with activated carbon particle electrode introduced in the three-dimensional electrodes, respectively. The higher removal efficiency for ammonia nitrogen than COD can be rendered by excited chloride ions, as they affect the competition between organic matter and ammonia nitrogen. Thus, SMBR combined with electrochemical oxidation possesses good prospects to be applied for efficient reduction of ammonia and COD in landfill leachates.
为有效处理垃圾渗滤液，研制了一种新型的膜生物反应器(SMBR)和氧化技术。结果表明，在2.0 ~ 2.3 kg COD/(m3·d)的有机负荷条件下，SMBR对氨氮和化学需氧量的去除率分别为91.2%和87.3%。采用Ti/ RuO2-IrO2阳极和不锈钢阴极组合对SMBR渗透膜进行电化学氧化。在40 mA/cm2电流密度下，电化学氧化3 h后，对氨氮和COD的去除率分别达到93.5%和66.9%。激发氯离子对氨氮的去除率高于COD，因为氯离子影响有机物与氨氮的竞争。因此，SMBR结合电化学氧化技术在垃圾渗滤液中高效还原氨氮和COD具有良好的应用前景。
{"title":"Treatment of Landfill Leachate by Combined Submerged Membrane Bioreactor (SMBR) and Electrochemical Oxidation","authors":"Bo Peng, Di Qiu, Xiaogang Wu","doi":"10.1166/NNL.2020.3185","DOIUrl":"https://doi.org/10.1166/NNL.2020.3185","url":null,"abstract":"To efficiently treat landfill leachate, we prepared a new integrated submerged membrane bioreactor (SMBR) and oxidation technology. Our results, under organic loading rates of 2.0–2.3 kg COD/(m3 ·d), showed that through SMBR we can acquire removal efficiencies\u0000 of 91.2% and 87.3% for ammonia and chemical oxygen demand (COD), respectively. A Ti/RuO2–IrO2 anode and stainless-steel cathode combination was engaged to carry out electrochemical oxidation of SMBR permeate. Ammonia and COD were removed after 3 h electrochemical\u0000 oxidation (at 40 mA/cm2 current density), and achieved 93.5% and 66.9% removal efficiency with activated carbon particle electrode introduced in the three-dimensional electrodes, respectively. The higher removal efficiency for ammonia nitrogen than COD can be rendered by excited\u0000 chloride ions, as they affect the competition between organic matter and ammonia nitrogen. Thus, SMBR combined with electrochemical oxidation possesses good prospects to be applied for efficient reduction of ammonia and COD in landfill leachates.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"953-960"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45678802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tian Liang, Hou Qinglin, Yingxia Wang, Yihui Hou, Tao Chen
Si/SiO2 composite green body with solid content of 50% was prepared by low toxic gel system and sintered in nitrogen at high temperature. Nitrogen compounds were synthesized in situ on fused silica ceramic substrate. The influence of different temperatures on nitriding reaction was discussed: different temperatures were used for nitriding at 1350 °C, 1400 °C, 1450 °C, 1500 °C. The effect of different nitriding times on nitriding reaction was discussed: different holding times were used for nitriding +1 h, 1.5 h, 2 h and 2.5 h. The best nitriding process was obtained by analyzing the composition, microstructure and properties of the nitrided samples.
{"title":"Effect of Carbothermal Reduction Nitriding of Si/SiO2 Composite Green on Properties of Fused Silica Ceramics","authors":"Tian Liang, Hou Qinglin, Yingxia Wang, Yihui Hou, Tao Chen","doi":"10.1166/NNL.2020.3191","DOIUrl":"https://doi.org/10.1166/NNL.2020.3191","url":null,"abstract":"Si/SiO2 composite green body with solid content of 50% was prepared by low toxic gel system and sintered in nitrogen at high temperature. Nitrogen compounds were synthesized in situ on fused silica ceramic substrate. The influence of different temperatures on nitriding reaction\u0000 was discussed: different temperatures were used for nitriding at 1350 °C, 1400 °C, 1450 °C, 1500 °C. The effect of different nitriding times on nitriding reaction was discussed: different holding times were used for nitriding +1 h, 1.5 h, 2 h and 2.5 h. The best nitriding process\u0000 was obtained by analyzing the composition, microstructure and properties of the nitrided samples.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"934-938"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48556995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiumei Zhang, Xianhai Zhu, Xiaolan Xu, Chen-wei Sun, J. Geng, Xuemei Fan
In this article, we investigated prevalence and distributed types of human papillomavirus (HPV) among female cervical squamous cell carcinoma patients in eastern China (mainly in Jiangsu Province). Tissue samples of total 1021 cases with cervical squamous cell carcinoma were incurred from female patients passing through biopsy or surgery. HPV DNA and genotypes of all subjects were examined using polymerase chain reaction (PCR) and gene-chip. There were 937 positive cases among 1021 cervical squamous cell carcinoma tissue samples with the total HPV infection rate of 91.77%. The HPV infection rate of single type was 75.42%. The predominant types of single infection with HPV were HPV 16 (52.60%), HPV 18 (5.19%), HPV 58 (4.51%), HPV 52 (2.84%), HPV 31 (2.74%), HPV 33 (2.45%), HPV 59 (1.76%) and HPV 45 (0.88%). The HPV infection rate of multiple types was 16.35%. The predominant types of multiple infection with HPV were HPV 16+18 (19.16%), 16+58 (6.59%),16+52 (5.99%), 16+33 (5.39%), 11+16 (2.99%), 16+31 (2.99%), 16+45 (2.99%), 16+42 (2.40%) and 16+59 (2.40%). Cervical squamous cell carcinomas had a close relationship with HPV infection. HPV 16, 18, 58, 52, 31, 33, 59, 45 with high prevalence in the cervical squamous cell carcinoma deserve great attention in eastern China (mainly in Jiangsu Province). The protection spectrum of divalent vaccine and ninevalent vaccine were, respectively, 68.52% (642/937) and 90.82% (851/937) in the cases of cervical squamous cell carcinomas.
{"title":"Clinical Analysis of Human Papillomavirus Infection Types Distribution in Tissues of Cervical Squamous Cell Carcinoma","authors":"Xiumei Zhang, Xianhai Zhu, Xiaolan Xu, Chen-wei Sun, J. Geng, Xuemei Fan","doi":"10.1166/NNL.2020.3181","DOIUrl":"https://doi.org/10.1166/NNL.2020.3181","url":null,"abstract":"In this article, we investigated prevalence and distributed types of human papillomavirus (HPV) among female cervical squamous cell carcinoma patients in eastern China (mainly in Jiangsu Province). Tissue samples of total 1021 cases with cervical squamous cell carcinoma were incurred\u0000 from female patients passing through biopsy or surgery. HPV DNA and genotypes of all subjects were examined using polymerase chain reaction (PCR) and gene-chip. There were 937 positive cases among 1021 cervical squamous cell carcinoma tissue samples with the total HPV infection rate of 91.77%.\u0000 The HPV infection rate of single type was 75.42%. The predominant types of single infection with HPV were HPV 16 (52.60%), HPV 18 (5.19%), HPV 58 (4.51%), HPV 52 (2.84%), HPV 31 (2.74%), HPV 33 (2.45%), HPV 59 (1.76%) and HPV 45 (0.88%). The HPV infection rate of multiple types was 16.35%.\u0000 The predominant types of multiple infection with HPV were HPV 16+18 (19.16%), 16+58 (6.59%),16+52 (5.99%), 16+33 (5.39%), 11+16 (2.99%), 16+31 (2.99%), 16+45 (2.99%), 16+42 (2.40%) and 16+59 (2.40%). Cervical squamous cell carcinomas had a close relationship with HPV infection. HPV 16, 18,\u0000 58, 52, 31, 33, 59, 45 with high prevalence in the cervical squamous cell carcinoma deserve great attention in eastern China (mainly in Jiangsu Province). The protection spectrum of divalent vaccine and ninevalent vaccine were, respectively, 68.52% (642/937) and 90.82% (851/937) in the cases\u0000 of cervical squamous cell carcinomas.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"921-927"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41799384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this investigation, various proportions of Pt@BaZrO3 (at 1∼4 wt.%) accommodating 2.0 wt% Pt were adopted to establish Pt@BaZrO3/g-C3N4 nanocomposites of improved photocatalytic performance. H2PtCl6 nanoparticles as well as mesoporous BaZrO3 and g-C3N4 were utilized to develop the prescribed nanocomposites via sonication-mixture routine. The photocatalytic achievement for the upgraded Pt@BaZrO3/g-C3N4 nanocomposites beneath visible light irradiation were tested by examining ciprofloxacin (CIP) degradation. Enhanced charge transfer and retarded charges’ recombination were established amid Pt, BaZrO3 NPs and g-C3N4 nanosheets in the developed heterojunctions. The proportion (wt.%) of Pt@BaZrO3 was found to be an essential parameter in governing the photocatalytic efficacy of the promoted Pt@BaZrO3/g-C3N4 nanocomposites. Moreover, complete photocatalytic decomposition of CIP was established over Pt@BaZrO3/g-C3N4 nanocomposite, accommodating 3 wt.% Pt@BaZrO3 NPs. Such superior performance was correlated to the great ability of the Pt@BaZrO3/g-C3N4 to absorb visible light in addition to the prolonged charge separation amid the photo-induced charge carriers.
{"title":"Enhanced Ciprofloxacin Degradation Over Pt@BaZrO3/g-C3N4 Heterojunctions Beneath Visible Light Illumination","authors":"M. Alhaddad","doi":"10.1166/NNL.2020.3190","DOIUrl":"https://doi.org/10.1166/NNL.2020.3190","url":null,"abstract":"In this investigation, various proportions of Pt@BaZrO3 (at 1∼4 wt.%) accommodating 2.0 wt% Pt were adopted to establish Pt@BaZrO3/g-C3N4 nanocomposites of improved photocatalytic performance. H2PtCl6 nanoparticles\u0000 as well as mesoporous BaZrO3 and g-C3N4 were utilized to develop the prescribed nanocomposites via sonication-mixture routine. The photocatalytic achievement for the upgraded Pt@BaZrO3/g-C3N4 nanocomposites beneath visible light\u0000 irradiation were tested by examining ciprofloxacin (CIP) degradation. Enhanced charge transfer and retarded charges’ recombination were established amid Pt, BaZrO3 NPs and g-C3N4 nanosheets in the developed heterojunctions. The proportion (wt.%) of Pt@BaZrO3\u0000 was found to be an essential parameter in governing the photocatalytic efficacy of the promoted Pt@BaZrO3/g-C3N4 nanocomposites. Moreover, complete photocatalytic decomposition of CIP was established over Pt@BaZrO3/g-C3N4 nanocomposite,\u0000 accommodating 3 wt.% Pt@BaZrO3 NPs. Such superior performance was correlated to the great ability of the Pt@BaZrO3/g-C3N4 to absorb visible light in addition to the prolonged charge separation amid the photo-induced charge carriers.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"874-884"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42803749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hua Wei, Hua Zhang, Yang Zhou, Zongbao Wang, Rong Wang, J. Chen
This study demonstrated the feasibility of polymer brushes-modified plate substrate as template to construct multilayer thin films via layer-by-layer hydrogen bonded assembly. The anchored chains via controlled surface-initiated atom transfer radical polymerization (SI-ATRP). The anchored poly(4-vinylpyridine) brushes functions as a multivalent H-acceptor to regulate the following hydrogen bonded assembly with H-donors to construct multilayer thin films via layer-by-layer deposition technique. The growth mechanism and film natures of multilayer films mediated by hydrogen bonded assembly from a polymer brushes-grafted surface were fully investigated.
{"title":"Understanding of Growth Mechanism and Structure of Multilayer Thin Films via Layer-by-Layer Hydrogen Bonded Assembly from Polymer Brushes-Grafted Surface","authors":"Hua Wei, Hua Zhang, Yang Zhou, Zongbao Wang, Rong Wang, J. Chen","doi":"10.1166/NNL.2020.3182","DOIUrl":"https://doi.org/10.1166/NNL.2020.3182","url":null,"abstract":"This study demonstrated the feasibility of polymer brushes-modified plate substrate as template to construct multilayer thin films via layer-by-layer hydrogen bonded assembly. The anchored chains via controlled surface-initiated atom transfer radical polymerization (SI-ATRP). The anchored\u0000 poly(4-vinylpyridine) brushes functions as a multivalent H-acceptor to regulate the following hydrogen bonded assembly with H-donors to construct multilayer thin films via layer-by-layer deposition technique. The growth mechanism and film natures of multilayer films mediated by hydrogen bonded\u0000 assembly from a polymer brushes-grafted surface were fully investigated.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"890-900"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49190946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aims to investigate the therapeutic effect of a paclitaxel-loaded nano-drug (PTX-mPEGPLA) on oral squamous cell carcinoma (OSCC). PTX-mPEG-PLA nanoparticle (NP) was prepared by loading paclitaxel into the mPEG-PLA nanoparticle and purified by a thin-film hydration method. C57BL/6 mice were used to establish a murine OSCC model. The mice were treated with saline control (G1), paclitaxel (G2), or PTX-mPEG-PLA NPs (G3). After 4 weeks of differential treatment, the saliva of mice in the G1, G2, and G3 groups was collected to detect the concentration of protein markers of OSCC. Also, venous blood and cancer tissues of mice in the three groups were collected for drug concentration measurements. The paclitaxel concentration and retention in G3 mice were significantly higher and more prolonged than those in G2 mice, respectively (P < 0.05). Compared to the level of OSCC protein markers in the saliva of mice in G1 and G2 that in G3 was the lowest. PTX-mPEG-PLA NPs demonstrates effective targeting in the treatment of oral squamous cell carcinoma in mice. It can deliver the drug to the cancerous tissues, increase the drug retention in the same tissues, and effectively inhibit the proliferation and metastasis of malignant tumors.
{"title":"Examining and Delivery and Retention of a Paclitaxel Nano-Drug in Oral Squamous Cell Carcinoma Tissues","authors":"Fengping Mou, Li Xiao, Yuanqin Xu","doi":"10.1166/NNL.2020.3196","DOIUrl":"https://doi.org/10.1166/NNL.2020.3196","url":null,"abstract":"This study aims to investigate the therapeutic effect of a paclitaxel-loaded nano-drug (PTX-mPEGPLA) on oral squamous cell carcinoma (OSCC). PTX-mPEG-PLA nanoparticle (NP) was prepared by loading paclitaxel into the mPEG-PLA nanoparticle and purified by a thin-film hydration method.\u0000 C57BL/6 mice were used to establish a murine OSCC model. The mice were treated with saline control (G1), paclitaxel (G2), or PTX-mPEG-PLA NPs (G3). After 4 weeks of differential treatment, the saliva of mice in the G1, G2, and G3 groups was collected to detect the concentration of protein\u0000 markers of OSCC. Also, venous blood and cancer tissues of mice in the three groups were collected for drug concentration measurements. The paclitaxel concentration and retention in G3 mice were significantly higher and more prolonged than those in G2 mice, respectively (P < 0.05).\u0000 Compared to the level of OSCC protein markers in the saliva of mice in G1 and G2 that in G3 was the lowest. PTX-mPEG-PLA NPs demonstrates effective targeting in the treatment of oral squamous cell carcinoma in mice. It can deliver the drug to the cancerous tissues, increase the drug retention\u0000 in the same tissues, and effectively inhibit the proliferation and metastasis of malignant tumors.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"946-952"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44052972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuan Wu, Cui-Zhong Liu, Ming Gao, Q. Liang, Yu Jiang
This study aimed to observe the effect of titanium nanomaterials on osteoblastsin vitro. Osteoblasts were identified using histochemical staining, and they were examined using an MTT (3-(4,5Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to determine the proliferation and differentiation of osteoblasts. In addition, we observed the effect of titanium nanomaterials on the function of osteoblasts. Compared with the control group, titanium nanomaterials promoted the growth, proliferation, and differentiation of osteoblasts. Our findings showed that titanium nanomaterials can significantly promote the proliferation of osteoblasts and enhance their osteogenic activity.
{"title":"Effect of Titanium Nanoparticles on Osteoblast Proliferation","authors":"Yuan Wu, Cui-Zhong Liu, Ming Gao, Q. Liang, Yu Jiang","doi":"10.1166/nnl.2020.3126","DOIUrl":"https://doi.org/10.1166/nnl.2020.3126","url":null,"abstract":"This study aimed to observe the effect of titanium nanomaterials on osteoblastsin vitro. Osteoblasts were identified using histochemical staining, and they were examined using an MTT (3-(4,5Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to determine the proliferation\u0000 and differentiation of osteoblasts. In addition, we observed the effect of titanium nanomaterials on the function of osteoblasts. Compared with the control group, titanium nanomaterials promoted the growth, proliferation, and differentiation of osteoblasts. Our findings showed that titanium\u0000 nanomaterials can significantly promote the proliferation of osteoblasts and enhance their osteogenic activity.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"455-460"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45646787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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