Pub Date : 2025-01-16DOI: 10.1038/s41477-024-01901-x
Sai-Xi Li, Yang Liu, Yan-Mei Zhang, Jian-Qun Chen, Zhu-Qing Shao
Plants deploy cell-surface pattern recognition receptors (PRRs) and intracellular nucleotide-binding site–leucine-rich repeat receptors (NLRs) to recognize pathogens. However, how plant immune receptor repertoires evolve in responding to changed pathogen burdens remains elusive. Here we reveal the convergent reduction of NLR repertoires in plants with diverse special lifestyles/habitats (SLHs) encountering low pathogen burdens. Furthermore, a parallel but milder reduction of PRR genes in SLH species was observed. The reduction of PRR and NLR genes was attributed to both increased gene loss and decreased gene duplication. Notably, pronounced loss of immune receptors was associated with the complete absence of signalling components from the enhanced disease susceptibility 1 (EDS1) and the resistance to powdery mildew 8 (RPW8)-NLR (RNL) families. In addition, evolutionary pattern analysis suggested that the conserved toll/interleukin-1 receptor (TIR)-only proteins might function tightly with EDS1/RNL. Taken together, these results reveal the hierarchically adaptive evolution of the two-tiered immune receptor repertoires during plant adaptation to diverse SLHs. Through surveying 808 angiosperm genomes, this study reveals that the two-tiered plant immune receptor repertoires display hierarchically adaptive reduction during plant adaptation to special lifestyles or habitats with low pathogen burdens.
{"title":"Convergent reduction of immune receptor repertoires during plant adaptation to diverse special lifestyles and habitats","authors":"Sai-Xi Li, Yang Liu, Yan-Mei Zhang, Jian-Qun Chen, Zhu-Qing Shao","doi":"10.1038/s41477-024-01901-x","DOIUrl":"10.1038/s41477-024-01901-x","url":null,"abstract":"Plants deploy cell-surface pattern recognition receptors (PRRs) and intracellular nucleotide-binding site–leucine-rich repeat receptors (NLRs) to recognize pathogens. However, how plant immune receptor repertoires evolve in responding to changed pathogen burdens remains elusive. Here we reveal the convergent reduction of NLR repertoires in plants with diverse special lifestyles/habitats (SLHs) encountering low pathogen burdens. Furthermore, a parallel but milder reduction of PRR genes in SLH species was observed. The reduction of PRR and NLR genes was attributed to both increased gene loss and decreased gene duplication. Notably, pronounced loss of immune receptors was associated with the complete absence of signalling components from the enhanced disease susceptibility 1 (EDS1) and the resistance to powdery mildew 8 (RPW8)-NLR (RNL) families. In addition, evolutionary pattern analysis suggested that the conserved toll/interleukin-1 receptor (TIR)-only proteins might function tightly with EDS1/RNL. Taken together, these results reveal the hierarchically adaptive evolution of the two-tiered immune receptor repertoires during plant adaptation to diverse SLHs. Through surveying 808 angiosperm genomes, this study reveals that the two-tiered plant immune receptor repertoires display hierarchically adaptive reduction during plant adaptation to special lifestyles or habitats with low pathogen burdens.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"11 2","pages":"248-262"},"PeriodicalIF":15.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1038/s41477-024-01899-2
Jing Nie, Hongyu Huang, Sheng Wu, Tao Lin, Lidong Zhang, Lijun Lv, Yuzi Shi, Yicong Guo, Qian Zhang, Yuhe Li, Weiliang Kong, Hujian Li, Zhen Yang, Wenbo Li, Lingjun Xu, Nan Ma, Zhonghua Zhang, Chuanqing Sun, Xiaolei Sui
Parthenocarpy is a pivotal trait that enhances the yield and quality of fruit crops by enabling the development of seedless fruits. Here we unveil a molecular framework for the regulation and domestication of parthenocarpy in cucumber (Cucumis sativus L.). We previously discovered a natural non-parthenocarpic mutant and demonstrated that the AP2-like transcription factor NON-PARTHENOCARPIC FRUIT 1 (NPF1) is a central regulator of parthenocarpy through activating YUC4 expression and promoting auxin biosynthesis in ovules. A Phe-to-Ser substitution at amino acid residue 7 results in a stable form of NPF1 that is localized in the nucleus. An A-to-G polymorphism (SNP-383) within an NPF1-binding site in the YUC4 promoter significantly enhances the activation of NPF1 towards YUC4, leading to an increased rate of parthenocarpy. Additionally, NPF1 influences bitterness by reducing cucurbitacin C biosynthesis through the suppression of Bt expression. Our results suggest a two-step evolutionary model for parthenocarpy and fruit bitterness during cucumber domestication. NPF1 governs parthenocarpy by activating YUC4 expression in the ovules of cucumber. The selection of a single mutation in the NPF1 gene, along with a SNP in the YUC4 promoter, led to parthenocarpic fruit development during cucumber domestication.
孤雌性是一种重要的性状，通过无籽果实的发育来提高水果作物的产量和品质。在此，我们揭示了黄瓜（Cucumis sativus L.）孤雌核发育调控和驯化的分子框架。我们之前发现了一个天然的非孤雌果突变体，并证明了ap2样转录因子non-parthenocarpic FRUIT 1 （NPF1）通过激活YUC4的表达和促进胚珠中生长素的生物合成，是孤雌果的中心调节因子。在氨基酸残基7上进行ph到ser的取代会产生一种稳定的NPF1，它位于细胞核内。YUC4启动子中NPF1结合位点的A-to-G多态性（SNP-383）显著增强了NPF1对YUC4的激活，导致孤雌繁殖率增加。此外，NPF1通过抑制Bt表达，减少葫芦素C的生物合成，从而影响苦味。本研究结果表明，黄瓜驯化过程中孤雌性和果实苦味的进化模式为两步进化模式。
{"title":"Molecular regulation and domestication of parthenocarpy in cucumber","authors":"Jing Nie, Hongyu Huang, Sheng Wu, Tao Lin, Lidong Zhang, Lijun Lv, Yuzi Shi, Yicong Guo, Qian Zhang, Yuhe Li, Weiliang Kong, Hujian Li, Zhen Yang, Wenbo Li, Lingjun Xu, Nan Ma, Zhonghua Zhang, Chuanqing Sun, Xiaolei Sui","doi":"10.1038/s41477-024-01899-2","DOIUrl":"10.1038/s41477-024-01899-2","url":null,"abstract":"Parthenocarpy is a pivotal trait that enhances the yield and quality of fruit crops by enabling the development of seedless fruits. Here we unveil a molecular framework for the regulation and domestication of parthenocarpy in cucumber (Cucumis sativus L.). We previously discovered a natural non-parthenocarpic mutant and demonstrated that the AP2-like transcription factor NON-PARTHENOCARPIC FRUIT 1 (NPF1) is a central regulator of parthenocarpy through activating YUC4 expression and promoting auxin biosynthesis in ovules. A Phe-to-Ser substitution at amino acid residue 7 results in a stable form of NPF1 that is localized in the nucleus. An A-to-G polymorphism (SNP-383) within an NPF1-binding site in the YUC4 promoter significantly enhances the activation of NPF1 towards YUC4, leading to an increased rate of parthenocarpy. Additionally, NPF1 influences bitterness by reducing cucurbitacin C biosynthesis through the suppression of Bt expression. Our results suggest a two-step evolutionary model for parthenocarpy and fruit bitterness during cucumber domestication. NPF1 governs parthenocarpy by activating YUC4 expression in the ovules of cucumber. The selection of a single mutation in the NPF1 gene, along with a SNP in the YUC4 promoter, led to parthenocarpic fruit development during cucumber domestication.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"11 2","pages":"176-190"},"PeriodicalIF":15.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Precise manipulation of genome structural variations holds great potential for plant trait improvement and biological research. Here we present a genome-editing approach, dual prime editing (DualPE), that efficiently facilitates precise deletion, replacement and inversion of large DNA fragments in plants. In our experiments, DualPE enabled the production of specific genomic deletions ranging from ~500 bp to 2 Mb in wheat protoplasts and plants. DualPE was effective in directly replacing wheat genomic fragments of up to 258 kb with desired sequences in the absence of donor DNA. Additionally, DualPE allowed precise DNA inversions of up to 205.4 kb in wheat plants with efficiencies of up to 51.5%. DualPE also successfully edited large DNA fragments in the dicots Nicotiana benthamiana and tomato, with editing efficiencies of up to 72.7%. DualPE thus provides a precise and efficient approach for large DNA sequence and chromosomal engineering, expanding the availability of precision genome-editing tools for crop improvement. This study explores a precise and efficient chromosome editing technology that enables the scarless deletion, replacement and inversion of large DNA fragments, up to the megabase scale, in plants and holds considerable promise for crop improvement.
{"title":"Precise deletion, replacement and inversion of large DNA fragments in plants using dual prime editing","authors":"Yidi Zhao, Zhengwei Huang, Ximeng Zhou, Wan Teng, Zehua Liu, Wenping Wang, Shengjia Tang, Ying Liu, Jing Liu, Wenxi Wang, Lingling Chai, Na Zhang, Weilong Guo, Jie Liu, Zhongfu Ni, Qixin Sun, Yanpeng Wang, Yuan Zong","doi":"10.1038/s41477-024-01898-3","DOIUrl":"10.1038/s41477-024-01898-3","url":null,"abstract":"Precise manipulation of genome structural variations holds great potential for plant trait improvement and biological research. Here we present a genome-editing approach, dual prime editing (DualPE), that efficiently facilitates precise deletion, replacement and inversion of large DNA fragments in plants. In our experiments, DualPE enabled the production of specific genomic deletions ranging from ~500 bp to 2 Mb in wheat protoplasts and plants. DualPE was effective in directly replacing wheat genomic fragments of up to 258 kb with desired sequences in the absence of donor DNA. Additionally, DualPE allowed precise DNA inversions of up to 205.4 kb in wheat plants with efficiencies of up to 51.5%. DualPE also successfully edited large DNA fragments in the dicots Nicotiana benthamiana and tomato, with editing efficiencies of up to 72.7%. DualPE thus provides a precise and efficient approach for large DNA sequence and chromosomal engineering, expanding the availability of precision genome-editing tools for crop improvement. This study explores a precise and efficient chromosome editing technology that enables the scarless deletion, replacement and inversion of large DNA fragments, up to the megabase scale, in plants and holds considerable promise for crop improvement.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"11 2","pages":"191-205"},"PeriodicalIF":15.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-10DOI: 10.1038/s41477-024-01900-y
This study reveals that the RNA N6-methyladenosine (m6A) demethylase SlALKBH2 undergoes a reduction–oxidation (redox) modification in which hydrogen peroxide mediates the oxidation and the reductase SlNTRC catalyses the reduction. This redox modification affects SlALKBH2 protein stability, thereby modulating its physiological function in the regulation of normal ripening of tomato fruits.
{"title":"Tomato fruit ripening is modulated by redox modification of RNA demethylase","authors":"","doi":"10.1038/s41477-024-01900-y","DOIUrl":"10.1038/s41477-024-01900-y","url":null,"abstract":"This study reveals that the RNA N6-methyladenosine (m6A) demethylase SlALKBH2 undergoes a reduction–oxidation (redox) modification in which hydrogen peroxide mediates the oxidation and the reductase SlNTRC catalyses the reduction. This redox modification affects SlALKBH2 protein stability, thereby modulating its physiological function in the regulation of normal ripening of tomato fruits.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"11 2","pages":"161-162"},"PeriodicalIF":15.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hydrogen peroxide (H2O2) functions as a critical signalling molecule in controlling multiple biological processes. How H2O2 signalling integrates with other regulatory pathways such as epigenetic modification to coordinately regulate plant development remains elusive. Here we report that SlALKBH2, an m6A demethylase required for normal ripening of tomato fruit, is sensitive to oxidative modification by H2O2, which leads to the formation of homodimers mediated by intermolecular disulfide bonds, and Cys39 serves as a key site in this process. The oxidation of SlALKBH2 promotes protein stability and facilitates its function towards the target transcripts including the pivotal ripening gene SlDML2 encoding a DNA demethylase. Furthermore, we demonstrate that the thioredoxin reductase SlNTRC interacts with SlALKBH2 and catalyses its reduction, thereby modulating m6A levels and fruit ripening. Our study establishes a molecular link between H2O2 and m6A methylation and highlights the importance of redox regulation of m6A modifiers in controlling fruit ripening. H2O2 plays a critical role in many aspects of plant development. This study uncovers that H2O2-mediated oxidative modification modulates the function of m6A demethylase SlALKBH2, thereby regulating fruit ripening in tomato.
{"title":"Redox modification of m6A demethylase SlALKBH2 in tomato regulates fruit ripening","authors":"Leilei Zhou, Guangtong Gao, Renkun Tang, Jinying Liu, Yuying Wang, Zhenchang Liang, Shiping Tian, Guozheng Qin","doi":"10.1038/s41477-024-01893-8","DOIUrl":"10.1038/s41477-024-01893-8","url":null,"abstract":"Hydrogen peroxide (H2O2) functions as a critical signalling molecule in controlling multiple biological processes. How H2O2 signalling integrates with other regulatory pathways such as epigenetic modification to coordinately regulate plant development remains elusive. Here we report that SlALKBH2, an m6A demethylase required for normal ripening of tomato fruit, is sensitive to oxidative modification by H2O2, which leads to the formation of homodimers mediated by intermolecular disulfide bonds, and Cys39 serves as a key site in this process. The oxidation of SlALKBH2 promotes protein stability and facilitates its function towards the target transcripts including the pivotal ripening gene SlDML2 encoding a DNA demethylase. Furthermore, we demonstrate that the thioredoxin reductase SlNTRC interacts with SlALKBH2 and catalyses its reduction, thereby modulating m6A levels and fruit ripening. Our study establishes a molecular link between H2O2 and m6A methylation and highlights the importance of redox regulation of m6A modifiers in controlling fruit ripening. H2O2 plays a critical role in many aspects of plant development. This study uncovers that H2O2-mediated oxidative modification modulates the function of m6A demethylase SlALKBH2, thereby regulating fruit ripening in tomato.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"11 2","pages":"218-233"},"PeriodicalIF":15.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-10DOI: 10.1038/s41477-024-01902-w
Yan Li, Bin Zhang, Songyao Zhang, Chui Eng Wong, Qiqi Liang, Shuai Pang, Yujin Wu, Ming Zhao, Hao Yu
Orchids constitute one of the most diverse families of angiosperms, yet their genome evolution and diversity remain unclear. Here we construct and analyse chromosome-scale de novo assembled genomes of 17 representative accessions spanning 12 sections in Dendrobium, one of the largest orchid genera. These accessions represent a broad spectrum of phenotypes, lineages and geographical distributions. We first construct haplotype-resolved genomes for a Dendrobium hybrid and uncover haplotypic variations and allelic imbalance in the heterozygous genome, demonstrating the significance of diverse ancestry. At Dendrobium genus-wide scale, we further elucidate phylogenetic relationships, evolutionary dynamics, entire gene repertoire, and the mechanisms of preserving ancient genetic variants and rapid recent genome evolution for habitat adaption. We also showcase distinctive evolutionary trajectories in MADS-box and PEBP families over 28 Ma. These results considerably contribute to unearthing the mystery of orchid origin, evolution and diversification, laying the foundation for efficient use of genetic diversity in breeding. This study explores the genome evolution and diversity of orchids by constructing and analysing chromosome-scale de novo assembled genomes of the representative accessions across 12 sections in Dendrobium, one of the largest orchid genera.
{"title":"Pangeneric genome analyses reveal the evolution and diversity of the orchid genus Dendrobium","authors":"Yan Li, Bin Zhang, Songyao Zhang, Chui Eng Wong, Qiqi Liang, Shuai Pang, Yujin Wu, Ming Zhao, Hao Yu","doi":"10.1038/s41477-024-01902-w","DOIUrl":"10.1038/s41477-024-01902-w","url":null,"abstract":"Orchids constitute one of the most diverse families of angiosperms, yet their genome evolution and diversity remain unclear. Here we construct and analyse chromosome-scale de novo assembled genomes of 17 representative accessions spanning 12 sections in Dendrobium, one of the largest orchid genera. These accessions represent a broad spectrum of phenotypes, lineages and geographical distributions. We first construct haplotype-resolved genomes for a Dendrobium hybrid and uncover haplotypic variations and allelic imbalance in the heterozygous genome, demonstrating the significance of diverse ancestry. At Dendrobium genus-wide scale, we further elucidate phylogenetic relationships, evolutionary dynamics, entire gene repertoire, and the mechanisms of preserving ancient genetic variants and rapid recent genome evolution for habitat adaption. We also showcase distinctive evolutionary trajectories in MADS-box and PEBP families over 28 Ma. These results considerably contribute to unearthing the mystery of orchid origin, evolution and diversification, laying the foundation for efficient use of genetic diversity in breeding. This study explores the genome evolution and diversity of orchids by constructing and analysing chromosome-scale de novo assembled genomes of the representative accessions across 12 sections in Dendrobium, one of the largest orchid genera.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"11 3","pages":"421-437"},"PeriodicalIF":15.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1038/s41477-024-01894-7
Haoxuan Li, Guanqun Wang, Chang Ye, Zhongyu Zou, Bochen Jiang, Fan Yang, Kayla He, Chengwei Ju, Lisheng Zhang, Boyang Gao, Shun Liu, Yanming Chen, Jianhua Zhang, Chuan He
Pseudouridine (Ψ) is the most abundant RNA modification, yet studies of Ψ have been hindered by a lack of robust methods to profile comprehensive Ψ maps. Here we utilize bisulfite-induced deletion sequencing to generate transcriptome-wide Ψ maps at single-base resolution across various plant species. Integrating ribosomal RNA, transfer RNA and messenger RNA Ψ stoichiometry with mRNA abundance and polysome profiling data, we uncover a multilayered regulation of translation efficiency through Ψ modifications. rRNA pseudouridylation could globally control translation, although the effects vary at different rRNA Ψ sites. Ψ in the tRNA T-arm loop shows strong positive correlations between Ψ stoichiometry and the translation efficiency of their respective codons. We observed a general inverse correlation between Ψ level and mRNA stability, but a positive correlation with translation efficiency in Arabidopsis seedlings. In conclusion, our study provides critical resources for Ψ research in plants and proposes prevalent translation regulation through rRNA, tRNA and mRNA pseudouridylation. The comprehensive and quantitative mapping of pseudouridine (Ψ) sites across four plant species provides critical resources for plant Ψ research, and reveals multilayered translation regulation through rRNA, tRNA and mRNA pseudouridylation in plants.
{"title":"Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation","authors":"Haoxuan Li, Guanqun Wang, Chang Ye, Zhongyu Zou, Bochen Jiang, Fan Yang, Kayla He, Chengwei Ju, Lisheng Zhang, Boyang Gao, Shun Liu, Yanming Chen, Jianhua Zhang, Chuan He","doi":"10.1038/s41477-024-01894-7","DOIUrl":"10.1038/s41477-024-01894-7","url":null,"abstract":"Pseudouridine (Ψ) is the most abundant RNA modification, yet studies of Ψ have been hindered by a lack of robust methods to profile comprehensive Ψ maps. Here we utilize bisulfite-induced deletion sequencing to generate transcriptome-wide Ψ maps at single-base resolution across various plant species. Integrating ribosomal RNA, transfer RNA and messenger RNA Ψ stoichiometry with mRNA abundance and polysome profiling data, we uncover a multilayered regulation of translation efficiency through Ψ modifications. rRNA pseudouridylation could globally control translation, although the effects vary at different rRNA Ψ sites. Ψ in the tRNA T-arm loop shows strong positive correlations between Ψ stoichiometry and the translation efficiency of their respective codons. We observed a general inverse correlation between Ψ level and mRNA stability, but a positive correlation with translation efficiency in Arabidopsis seedlings. In conclusion, our study provides critical resources for Ψ research in plants and proposes prevalent translation regulation through rRNA, tRNA and mRNA pseudouridylation. The comprehensive and quantitative mapping of pseudouridine (Ψ) sites across four plant species provides critical resources for plant Ψ research, and reveals multilayered translation regulation through rRNA, tRNA and mRNA pseudouridylation in plants.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"11 2","pages":"234-247"},"PeriodicalIF":15.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-06DOI: 10.1038/s41477-024-01891-w
Kaihuai Li, Yan Qiao, Huan Chen, Fengquan Liu
Toll/interleukin-1 receptor (TIR) domain proteins possess NADase activity and trigger plant immunity via their enzymatic products. Two recent studies have elucidated the mechanism by which TIR NADase-derived 2′cADPR and pRib-AMP/ADP activate EDS1–PAD4–ADR1 (EPA) signalling, thereby inducing immune responses in plants.
{"title":"Small molecules unlock broad-spectrum plant resistance","authors":"Kaihuai Li, Yan Qiao, Huan Chen, Fengquan Liu","doi":"10.1038/s41477-024-01891-w","DOIUrl":"10.1038/s41477-024-01891-w","url":null,"abstract":"Toll/interleukin-1 receptor (TIR) domain proteins possess NADase activity and trigger plant immunity via their enzymatic products. Two recent studies have elucidated the mechanism by which TIR NADase-derived 2′cADPR and pRib-AMP/ADP activate EDS1–PAD4–ADR1 (EPA) signalling, thereby inducing immune responses in plants.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"11 1","pages":"11-13"},"PeriodicalIF":15.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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