首页 > 最新文献

Nutrition Journal最新文献

英文 中文
Association of maternal ultra-processed food consumption during pregnancy with atopic dermatitis in infancy: Korean Mothers and Children's Environmental Health (MOCEH) study. 母亲在怀孕期间食用超加工食品与婴儿特应性皮炎的关系:韩国母亲与儿童环境健康(MOCEH)研究。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-25 DOI: 10.1186/s12937-024-00969-7
Won Jang, Minji Kim, Eunhee Ha, Hyesook Kim

Background: Maternal diet during pregnancy might influence the development of childhood allergic disorders. There are few studies on the association between processed food intake and infant atopic dermatitis (AD) during pregnancy. The aim of the present study was to investigate the association of ultra-processed food (UPF) intake during pregnancy with infantile AD.

Methods: This study involved 861 pairs of pregnant women and their offspring from the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project conducted in Korea. Dietary intake was estimated using a 24-h recall method at 12-28 weeks gestation. The NOVA classification was used to identify UPF, and UPF intake was calculated as the percentage of total energy consumption and categorized into quartiles. Infantile AD was assessed based on medical history and the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC). Associations were assessed by logistic regression with adjustment for confounding factors.

Results: Children born to mothers in the highest quartile of UPF consumption (15.5% or more of the total energy) compared to the lowest quartile (6.8% or less) showed a higher risk of AD within 12 months [odds ratio (OR) = 1.69; 95% confidence interval (CI): 1.07-2.66, P for trend 0.0436]. After adjustment for the confounding factors under study, the association was strengthened; the adjusted OR between extreme quartiles was 2.19 (95% CI: 1.11-4.32, P for trend = 0.0418). This association was maintained even after an additional adjustment based on the Korean Healthy Eating Index (KHEI), an indicator of diet quality.

Conclusions: Higher maternal consumption of UPF during pregnancy was associated with a greater risk of infantile AD within the first year of life.

背景:母亲在怀孕期间的饮食可能会影响儿童过敏性疾病的发展。有关孕期加工食品摄入量与婴儿特应性皮炎(AD)之间关系的研究很少。本研究旨在探讨孕期超加工食品(UPF)摄入量与婴儿特应性皮炎的关系:本研究涉及861对孕妇及其后代,这些孕妇和后代均来自母亲和儿童环境健康(MOCEH)研究,这是一项在韩国开展的多中心出生队列项目。膳食摄入量是通过妊娠 12-28 周时的 24 小时回忆法估算的。NOVA分类法用于识别UPF,UPF摄入量按总能量消耗的百分比计算,并分为四等分。根据病史和国际儿童哮喘和过敏症研究(ISAAC)的标准对婴儿哮喘进行评估。在对混杂因素进行调整后,通过逻辑回归评估了两者之间的关联:UPF消耗量最高四分位数(占总能量的15.5%或以上)的母亲与最低四分位数(占总能量的6.8%或以下)的母亲所生的孩子相比,在12个月内患AD的风险更高[几率比(OR)=1.69;95%置信区间(CI):1.07-2.66,趋势P为0.0436]。在对研究中的混杂因素进行调整后,这种关联得到了加强;极端四分位数之间的调整后 OR 为 2.19(95% 置信区间:1.11-4.32,趋势 P = 0.0418)。根据韩国健康饮食指数(KHEI)这一饮食质量指标进行额外调整后,这一关联仍得以保持:结论:孕妇在怀孕期间摄入较多的UPF与婴儿出生后第一年内患AD的风险较高有关。
{"title":"Association of maternal ultra-processed food consumption during pregnancy with atopic dermatitis in infancy: Korean Mothers and Children's Environmental Health (MOCEH) study.","authors":"Won Jang, Minji Kim, Eunhee Ha, Hyesook Kim","doi":"10.1186/s12937-024-00969-7","DOIUrl":"10.1186/s12937-024-00969-7","url":null,"abstract":"<p><strong>Background: </strong>Maternal diet during pregnancy might influence the development of childhood allergic disorders. There are few studies on the association between processed food intake and infant atopic dermatitis (AD) during pregnancy. The aim of the present study was to investigate the association of ultra-processed food (UPF) intake during pregnancy with infantile AD.</p><p><strong>Methods: </strong>This study involved 861 pairs of pregnant women and their offspring from the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project conducted in Korea. Dietary intake was estimated using a 24-h recall method at 12-28 weeks gestation. The NOVA classification was used to identify UPF, and UPF intake was calculated as the percentage of total energy consumption and categorized into quartiles. Infantile AD was assessed based on medical history and the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC). Associations were assessed by logistic regression with adjustment for confounding factors.</p><p><strong>Results: </strong>Children born to mothers in the highest quartile of UPF consumption (15.5% or more of the total energy) compared to the lowest quartile (6.8% or less) showed a higher risk of AD within 12 months [odds ratio (OR) = 1.69; 95% confidence interval (CI): 1.07-2.66, P for trend 0.0436]. After adjustment for the confounding factors under study, the association was strengthened; the adjusted OR between extreme quartiles was 2.19 (95% CI: 1.11-4.32, P for trend = 0.0418). This association was maintained even after an additional adjustment based on the Korean Healthy Eating Index (KHEI), an indicator of diet quality.</p><p><strong>Conclusions: </strong>Higher maternal consumption of UPF during pregnancy was associated with a greater risk of infantile AD within the first year of life.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the relative validity of a web-based self-administered 24-hour dietary recall in a Canadian adolescent's population. 在加拿大青少年群体中评估基于网络的 24 小时自我管理饮食回忆的相对有效性。
IF 4.4 2区 医学 Q1 Medicine Pub Date : 2024-06-21 DOI: 10.1186/s12937-024-00954-0
Vicky Drapeau, Catherine Laramée, Jacynthe Lafreniere, Christiane Trottier, Charlotte Brochu, Julie Robitaille, Benoît Lamarche, Simone Lemieux

Background: Healthy eating habits at a young age are crucial to support growth and development and good general health. In this context, monitoring youth dietary intakes adequately with valid tools is important to develop efficient interventions and identify groups that are more at risk of inadequate intakes. This study aimed to assess the relative validity of the self-administered web-based 24-h dietary recall (R24W) for evaluating energy and nutrient intakes among active adolescents.

Methods: Participants were invited to complete one interviewer-administered 24-h dietary dietary recall and the R24W on up to three occasions within one month. A total of 272 French-speaking active adolescents aged 12 to 17 years from the province of Québec were invited to complete three R24W and one interview-administered 24-h recall. Student's t-test and correlations were conducted on sex-adjusted data. Percent differences, cross-classification (percentage of agreement), weighted Kappa and Bland-Altman plots were calculated.

Results: Mean (SD) energy intake from the R24W was 8.8% higher than from the interview-administered 24-h dietary recall (2558 kcal ± 1128 vs. 2444 kcal ± 998, p < 0.05). Significant differences in mean nutrient intake between the R24W and the interview-administered 24-h dietary recall ranged from 6.5% for % E from fat (p < 0.05) to 25.2% for saturated fat (p < 0.001), i.e., higher values with R24W. Sex-adjusted correlations were significant for all nutrients except for % E from proteins and thiamin (range: 0.24 to 0.52, p < 0.01). Cross-classification demonstrated that 36.6% of the participants were classified in the same fourth with both methods, 39.6% in the adjacent fourth, and 5.7% misclassified. Bland-Atman plots revealed proportional bias between the two methods for 7/25 nutrients. Completing at least two recalls with the R24W increased the precision of intake estimates.

Conclusion: These data suggest that the R24W presents an acceptable relative validity compared to a standard interview-administered 24-h recall for estimating energy and most nutrients in a cohort of French-speaking adolescents from the province of Québec.

背景:年轻时养成健康的饮食习惯对促进生长发育和总体健康至关重要。在这种情况下,使用有效的工具充分监测青少年的膳食摄入量对于制定有效的干预措施和识别摄入量不足风险较高的群体非常重要。本研究旨在评估基于网络的 24 小时膳食回顾(R24W)在评估好动青少年的能量和营养素摄入量方面的相对有效性:方法:邀请参与者在一个月内完成一次由访谈者主持的 24 小时膳食回顾和 R24W,最多三次。魁北克省共邀请了 272 名 12 至 17 岁的法语青少年完成了三次 R24W 和一次访谈式 24 小时膳食回忆。对性别调整后的数据进行了学生 t 检验和相关分析。计算了差异百分比、交叉分类(一致百分比)、加权 Kappa 和 Bland-Altman 图:这些数据表明,在对魁北克省讲法语的青少年群体进行能量和大多数营养素的估计时,R24W 与标准的访谈式 24 小时膳食回忆相比,具有可接受的相对有效性。
{"title":"Assessing the relative validity of a web-based self-administered 24-hour dietary recall in a Canadian adolescent's population.","authors":"Vicky Drapeau, Catherine Laramée, Jacynthe Lafreniere, Christiane Trottier, Charlotte Brochu, Julie Robitaille, Benoît Lamarche, Simone Lemieux","doi":"10.1186/s12937-024-00954-0","DOIUrl":"10.1186/s12937-024-00954-0","url":null,"abstract":"<p><strong>Background: </strong>Healthy eating habits at a young age are crucial to support growth and development and good general health. In this context, monitoring youth dietary intakes adequately with valid tools is important to develop efficient interventions and identify groups that are more at risk of inadequate intakes. This study aimed to assess the relative validity of the self-administered web-based 24-h dietary recall (R24W) for evaluating energy and nutrient intakes among active adolescents.</p><p><strong>Methods: </strong>Participants were invited to complete one interviewer-administered 24-h dietary dietary recall and the R24W on up to three occasions within one month. A total of 272 French-speaking active adolescents aged 12 to 17 years from the province of Québec were invited to complete three R24W and one interview-administered 24-h recall. Student's t-test and correlations were conducted on sex-adjusted data. Percent differences, cross-classification (percentage of agreement), weighted Kappa and Bland-Altman plots were calculated.</p><p><strong>Results: </strong>Mean (SD) energy intake from the R24W was 8.8% higher than from the interview-administered 24-h dietary recall (2558 kcal ± 1128 vs. 2444 kcal ± 998, p < 0.05). Significant differences in mean nutrient intake between the R24W and the interview-administered 24-h dietary recall ranged from 6.5% for % E from fat (p < 0.05) to 25.2% for saturated fat (p < 0.001), i.e., higher values with R24W. Sex-adjusted correlations were significant for all nutrients except for % E from proteins and thiamin (range: 0.24 to 0.52, p < 0.01). Cross-classification demonstrated that 36.6% of the participants were classified in the same fourth with both methods, 39.6% in the adjacent fourth, and 5.7% misclassified. Bland-Atman plots revealed proportional bias between the two methods for 7/25 nutrients. Completing at least two recalls with the R24W increased the precision of intake estimates.</p><p><strong>Conclusion: </strong>These data suggest that the R24W presents an acceptable relative validity compared to a standard interview-administered 24-h recall for estimating energy and most nutrients in a cohort of French-speaking adolescents from the province of Québec.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of DASH diet with or without time-restricted eating in the management of stage 1 primary hypertension: a randomized controlled trial 采用或不采用限时进食法的 DASH 饮食对治疗 1 期原发性高血压的效果:随机对照试验
IF 5.4 2区 医学 Q1 Medicine Pub Date : 2024-06-17 DOI: 10.1186/s12937-024-00967-9
Xiaoxin Zhou, Xiaoqian Lin, Jing Yu, Yi Yang, Hira Muzammel, Said Amissi, Valérie B. Schini-Kerth, Xun Lei, Pedro A. Jose, Jian Yang, Dan Shi
{"title":"Effects of DASH diet with or without time-restricted eating in the management of stage 1 primary hypertension: a randomized controlled trial","authors":"Xiaoxin Zhou, Xiaoqian Lin, Jing Yu, Yi Yang, Hira Muzammel, Said Amissi, Valérie B. Schini-Kerth, Xun Lei, Pedro A. Jose, Jian Yang, Dan Shi","doi":"10.1186/s12937-024-00967-9","DOIUrl":"https://doi.org/10.1186/s12937-024-00967-9","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive approach to lifestyle intervention based on a calorie-restricted diet ameliorates liver fat in overweight/obese patients with NAFLD: a multicenter randomized controlled trial in China. 基于卡路里限制饮食的综合生活方式干预可改善非酒精性脂肪肝的超重/肥胖患者的肝脏脂肪状况:中国多中心随机对照试验。
IF 5.4 2区 医学 Q1 Medicine Pub Date : 2024-06-13 DOI: 10.1186/s12937-024-00968-8
Zhong Liu, Piaopiao Jin, Yuping Liu, Zhimian Zhang, Xiangming Wu, Min Weng, Suyan Cao, Yan Wang, Chang Zeng, Rui Yang, Chenbing Liu, Ping Sun, Cuihuan Tian, Nan Li, Qiang Zeng

Background: Nonalcoholic fatty liver disease (NAFLD) is a globally increasing health epidemic. Lifestyle intervention is recommended as the main therapy for NAFLD. However, the optimal approach is still unclear. This study aimed to evaluate the effects of a comprehensive approach of intensive lifestyle intervention (ILI) concerning enhanced control of calorie-restricted diet (CRD), exercise, and personalized nutrition counseling on liver steatosis and extrahepatic metabolic status in Chinese overweight and obese patients with NAFLD.

Methods: This study was a multicenter randomized controlled trial (RCT) conducted across seven hospitals in China. It involved 226 participants with a body mass index (BMI) above 25. These participants were randomly assigned to two groups: the ILI group, which followed a low carbohydrate, high protein CRD combined with exercise and intensive counseling from a dietitian, and a control group, which adhered to a balanced CRD along with exercise and standard counseling. The main measure of the study was the change in the fat attenuation parameter (FAP) from the start of the study to week 12, analyzed within the per-protocol set. Secondary measures included changes in BMI, liver stiffness measurement (LSM), and the improvement of various metabolic indexes. Additionally, predetermined subgroup analyses of the FAP were conducted based on variables like gender, age, BMI, ethnicity, hyperlipidemia, and hypertension.

Results: A total of 167 participants completed the whole study. Compared to the control group, ILI participants achieved a significant reduction in FAP (LS mean difference, 16.07 [95% CI: 8.90-23.25] dB/m) and BMI (LS mean difference, 1.46 [95% CI: 1.09-1.82] kg/m2) but not in LSM improvement (LS mean difference, 0.20 [95% CI: -0.19-0.59] kPa). The ILI also substantially improved other secondary outcomes (including ALT, AST, GGT, body fat mass, muscle mass and skeletal muscle mass, triglyceride, fasting blood glucose, fasting insulin, HbA1c, HOMA-IR, HOMA-β, blood pressure, and homocysteine). Further subgroup analyses showed that ILI, rather than control intervention, led to more significant FAP reduction, especially in patients with concurrent hypertension (p < 0.001).

Conclusion: In this RCT, a 12-week intensive lifestyle intervention program led to significant improvements in liver steatosis and other metabolic indicators in overweight and obese Chinese patients suffering from nonalcoholic fatty liver disease. Further research is required to confirm the long-term advantages and practicality of this approach.

Trial registration: This clinical trial was registered on ClinicalTrials.gov (registration number: NCT03972631) in June 2019.

背景:非酒精性脂肪肝(NAFLD)是一种全球日益流行的疾病。生活方式干预被推荐为治疗非酒精性脂肪肝的主要方法。然而,最佳方法仍不明确。本研究旨在评估强化生活方式干预(ILI)的综合方法对中国超重和肥胖非酒精性脂肪肝患者肝脏脂肪变性和肝外代谢状况的影响:本研究是一项多中心随机对照试验(RCT),在中国七家医院进行。226名参与者的体重指数(BMI)超过25。这些参与者被随机分配到两组:ILI 组和对照组,前者采用低碳水化合物、高蛋白的 CRD,同时配合运动和营养师的强化辅导;后者采用均衡的 CRD,同时配合运动和标准辅导。研究的主要衡量指标是脂肪衰减参数(FAP)从研究开始到第 12 周的变化,并在按方案设定的范围内进行分析。次要衡量指标包括体重指数(BMI)的变化、肝脏硬度测量(LSM)以及各种代谢指标的改善情况。此外,还根据性别、年龄、体重指数、种族、高脂血症和高血压等变量对 FAP 进行了预先确定的亚组分析:共有 167 人完成了整个研究。与对照组相比,ILI 参与者的 FAP(LS 平均差值,16.07 [95% CI:8.90-23.25] dB/m)和 BMI(LS 平均差值,1.46 [95% CI:1.09-1.82] kg/m2)显著降低,但 LSM 改善幅度不大(LS 平均差值,0.20 [95% CI:-0.19-0.59] kPa)。ILI 还显著改善了其他次要结果(包括谷丙转氨酶、谷草转氨酶、谷草转氨酶、体脂质量、肌肉质量和骨骼肌质量、甘油三酯、空腹血糖、空腹胰岛素、HbA1c、HOMA-IR、HOMA-β、血压和同型半胱氨酸)。进一步的亚组分析表明,ILI 比对照干预能更显著地降低 FAP,尤其是在同时患有高血压的患者中(P 结论:ILI 比对照干预能更显著地降低 FAP,尤其是在同时患有高血压的患者中):在这项研究中,为期 12 周的强化生活方式干预计划显著改善了中国超重和肥胖非酒精性脂肪肝患者的肝脏脂肪变性和其他代谢指标。要证实这种方法的长期优势和实用性,还需要进一步的研究:本临床试验于2019年6月在ClinicalTrials.gov上注册(注册号:NCT03972631)。
{"title":"A comprehensive approach to lifestyle intervention based on a calorie-restricted diet ameliorates liver fat in overweight/obese patients with NAFLD: a multicenter randomized controlled trial in China.","authors":"Zhong Liu, Piaopiao Jin, Yuping Liu, Zhimian Zhang, Xiangming Wu, Min Weng, Suyan Cao, Yan Wang, Chang Zeng, Rui Yang, Chenbing Liu, Ping Sun, Cuihuan Tian, Nan Li, Qiang Zeng","doi":"10.1186/s12937-024-00968-8","DOIUrl":"10.1186/s12937-024-00968-8","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic fatty liver disease (NAFLD) is a globally increasing health epidemic. Lifestyle intervention is recommended as the main therapy for NAFLD. However, the optimal approach is still unclear. This study aimed to evaluate the effects of a comprehensive approach of intensive lifestyle intervention (ILI) concerning enhanced control of calorie-restricted diet (CRD), exercise, and personalized nutrition counseling on liver steatosis and extrahepatic metabolic status in Chinese overweight and obese patients with NAFLD.</p><p><strong>Methods: </strong>This study was a multicenter randomized controlled trial (RCT) conducted across seven hospitals in China. It involved 226 participants with a body mass index (BMI) above 25. These participants were randomly assigned to two groups: the ILI group, which followed a low carbohydrate, high protein CRD combined with exercise and intensive counseling from a dietitian, and a control group, which adhered to a balanced CRD along with exercise and standard counseling. The main measure of the study was the change in the fat attenuation parameter (FAP) from the start of the study to week 12, analyzed within the per-protocol set. Secondary measures included changes in BMI, liver stiffness measurement (LSM), and the improvement of various metabolic indexes. Additionally, predetermined subgroup analyses of the FAP were conducted based on variables like gender, age, BMI, ethnicity, hyperlipidemia, and hypertension.</p><p><strong>Results: </strong>A total of 167 participants completed the whole study. Compared to the control group, ILI participants achieved a significant reduction in FAP (LS mean difference, 16.07 [95% CI: 8.90-23.25] dB/m) and BMI (LS mean difference, 1.46 [95% CI: 1.09-1.82] kg/m<sup>2</sup>) but not in LSM improvement (LS mean difference, 0.20 [95% CI: -0.19-0.59] kPa). The ILI also substantially improved other secondary outcomes (including ALT, AST, GGT, body fat mass, muscle mass and skeletal muscle mass, triglyceride, fasting blood glucose, fasting insulin, HbA1c, HOMA-IR, HOMA-β, blood pressure, and homocysteine). Further subgroup analyses showed that ILI, rather than control intervention, led to more significant FAP reduction, especially in patients with concurrent hypertension (p < 0.001).</p><p><strong>Conclusion: </strong>In this RCT, a 12-week intensive lifestyle intervention program led to significant improvements in liver steatosis and other metabolic indicators in overweight and obese Chinese patients suffering from nonalcoholic fatty liver disease. Further research is required to confirm the long-term advantages and practicality of this approach.</p><p><strong>Trial registration: </strong>This clinical trial was registered on ClinicalTrials.gov (registration number: NCT03972631) in June 2019.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11170812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fish oil supplementation and risk of incident systemic lupus erythematosus: a large population-based prospective study. 鱼油补充剂与系统性红斑狼疮发病风险:一项大型人群前瞻性研究。
IF 5.4 2区 医学 Q1 Medicine Pub Date : 2024-06-12 DOI: 10.1186/s12937-024-00965-x
Yancong Chen, Zhilan Li, Yinyan Gao, Boya Xu, Weiru Zhang, Irene X Y Wu

Background: Although fish oil has been considered to have an anti-inflammatory effect and has been proven to play a beneficial role in the incidence of numerous diseases, the association between fish oil supplementation and the risk of systemic lupus erythematosus (SLE) is still unknown. This study aimed at evaluating the correlation between fish oil use and incident SLE in a large population-based prospective cohort.

Methods: 390,277 participants without SLE at baseline from the UK Biobank were enrolled. Fish oil use was ascertained through a touchscreen questionnaire at baseline. The incidence of SLE was identified by the International Classification of Diseases version 10 code in medical records or self-report. Cox proportional hazard models were employed to estimate the association between fish oil use and SLE risk.

Results: Fish oil users accounted for 31.47% of participants. During a median follow-up duration of 11.57 years, 141 participants without fish oil use (4.56/100 000 person-years) and 68 participants with fish oil use (4.78/100 000 person-years) developed SLE. In four models with adjustments for different amounts of confounders, there was no significant difference in the risk of SLE between fish oil users and fish oil non-users (all p-values > 0.05). In subgroup analyses, we found that fish oil supplementation was associated with a lower risk of SLE among females with ultraviolet radiation ≥ 3 h/day (hazard ratio: 0.63, 95% confidence interval: 0.40-0.98), which turned insignificant after further adjustment for female-related factors and sun protection measures.

Conclusions: No significant association between fish oil use and overall incident SLE was observed, except in females exposed to prolonged ultraviolet radiation. Subgroup analysis suggested that females exposed to prolonged ultraviolet radiation might benefit from fish oil supplementation in terms of preventing SLE, but it needs to be confirmed in further studies.

背景:尽管鱼油被认为具有抗炎作用,并已被证实对多种疾病的发病率有益,但鱼油补充剂与系统性红斑狼疮(SLE)发病风险之间的关系仍然未知。这项研究的目的是在一个基于人群的大型前瞻性队列中评估鱼油的使用与系统性红斑狼疮发病之间的相关性。通过基线触摸屏问卷调查确定了鱼油的使用情况。系统性红斑狼疮的发病率是通过医疗记录中的国际疾病分类第 10 版代码或自我报告确定的。采用 Cox 比例危险模型来估计鱼油使用与系统性红斑狼疮风险之间的关系:结果:鱼油使用者占参与者的31.47%。在中位 11.57 年的随访期间,141 名未使用鱼油的参与者(4.56/100 000 人-年)和 68 名使用鱼油的参与者(4.78/100 000 人-年)患上了系统性红斑狼疮。在对不同数量的混杂因素进行调整的四个模型中,鱼油使用者和非鱼油使用者患系统性红斑狼疮的风险没有显著差异(所有 p 值均大于 0.05)。在亚组分析中,我们发现在紫外线辐射≥3小时/天的女性中,补充鱼油与较低的系统性红斑狼疮风险相关(危险比:0.63,95%置信区间:0.40-0.98),在进一步调整女性相关因素和防晒措施后,危险比变得不显著:结论:除长期暴露于紫外线辐射的女性外,没有观察到鱼油的使用与系统性红斑狼疮的总体发病率有明显关系。亚组分析表明,长期暴露于紫外线辐射下的女性可能会从补充鱼油中获益,从而预防系统性红斑狼疮,但这还需要进一步研究证实。
{"title":"Fish oil supplementation and risk of incident systemic lupus erythematosus: a large population-based prospective study.","authors":"Yancong Chen, Zhilan Li, Yinyan Gao, Boya Xu, Weiru Zhang, Irene X Y Wu","doi":"10.1186/s12937-024-00965-x","DOIUrl":"10.1186/s12937-024-00965-x","url":null,"abstract":"<p><strong>Background: </strong>Although fish oil has been considered to have an anti-inflammatory effect and has been proven to play a beneficial role in the incidence of numerous diseases, the association between fish oil supplementation and the risk of systemic lupus erythematosus (SLE) is still unknown. This study aimed at evaluating the correlation between fish oil use and incident SLE in a large population-based prospective cohort.</p><p><strong>Methods: </strong>390,277 participants without SLE at baseline from the UK Biobank were enrolled. Fish oil use was ascertained through a touchscreen questionnaire at baseline. The incidence of SLE was identified by the International Classification of Diseases version 10 code in medical records or self-report. Cox proportional hazard models were employed to estimate the association between fish oil use and SLE risk.</p><p><strong>Results: </strong>Fish oil users accounted for 31.47% of participants. During a median follow-up duration of 11.57 years, 141 participants without fish oil use (4.56/100 000 person-years) and 68 participants with fish oil use (4.78/100 000 person-years) developed SLE. In four models with adjustments for different amounts of confounders, there was no significant difference in the risk of SLE between fish oil users and fish oil non-users (all p-values > 0.05). In subgroup analyses, we found that fish oil supplementation was associated with a lower risk of SLE among females with ultraviolet radiation ≥ 3 h/day (hazard ratio: 0.63, 95% confidence interval: 0.40-0.98), which turned insignificant after further adjustment for female-related factors and sun protection measures.</p><p><strong>Conclusions: </strong>No significant association between fish oil use and overall incident SLE was observed, except in females exposed to prolonged ultraviolet radiation. Subgroup analysis suggested that females exposed to prolonged ultraviolet radiation might benefit from fish oil supplementation in terms of preventing SLE, but it needs to be confirmed in further studies.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention. 在为期 3 年的地中海饮食干预期间,患有代谢综合征的老年人的性别、APOE 基因型、内源性大麻素与认知变化之间的关系。
IF 4.4 2区 医学 Q1 Medicine Pub Date : 2024-06-12 DOI: 10.1186/s12937-024-00966-w
Natalia Soldevila-Domenech, Beatriz Fagundo, Aida Cuenca-Royo, Laura Forcano, Maria Gomis-González, Anna Boronat, Antoni Pastor, Olga Castañer, Maria Dolores Zomeño, Albert Goday, Mara Dierssen, Khashayar Baghizadeh Hosseini, Emilio Ros, Dolores Corella, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Fernando Fernández-Aranda, Montserrat Fitó, Rafael de la Torre

Background: The Mediterranean diet (MedDiet) has demonstrated efficacy in preventing age-related cognitive decline and modulating plasma concentrations of endocannabinoids (eCBs) and N-acylethanolamines (NAEs, or eCB-like compounds), which are lipid mediators involved in multiple neurological disorders and metabolic processes. Hypothesizing that eCBs and NAEs will be biomarkers of a MedDiet intervention and will be related to the cognitive response, we investigated this relationship according to sex and apolipoprotein E (APOE) genotype, which may affect eCBs and cognitive performance.

Methods: This was a prospective cohort study of 102 participants (53.9% women, 18.8% APOE-ɛ4 carriers, aged 65.6 ± 4.5 years) from the PREDIMED-Plus-Cognition substudy, who were recruited at the Hospital del Mar Research Institute (Barcelona). All of them presented metabolic syndrome plus overweight/obesity (inclusion criteria of the PREDIMED-Plus) and normal cognitive performance at baseline (inclusion criteria of this substudy). A comprehensive battery of neuropsychological tests was administered at baseline and after 1 and 3 years. Plasma concentrations of eCBs and NAEs, including 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and N-docosahexaenoylethanolamine (DHEA), were also monitored. Baseline cognition, cognitive changes, and the association between eCBs/NAEs and cognition were evaluated according to gender (crude models), sex (adjusted models), and APOE genotype.

Results: At baseline, men had better executive function and global cognition than women (the effect size of gender differences was - 0.49, p = 0.015; and - 0.42, p = 0.036); however, these differences became nonsignificant in models of sex differences. After 3 years of MedDiet intervention, participants exhibited modest improvements in memory and global cognition. However, greater memory changes were observed in men than in women (Cohen's d of 0.40 vs. 0.25; p = 0.017). In men and APOE-ε4 carriers, 2-AG concentrations were inversely associated with baseline cognition and cognitive changes, while in women, cognitive changes were positively linked to changes in DHEA and the DHEA/AEA ratio. In men, changes in the OEA/AEA and OEA/PEA ratios were positively associated with cognitive changes.

Conclusions: The MedDiet improved participants' cognitive performance but the effect size was small and negatively influenced by female sex. Changes in 2-AG, DHEA, the OEA/AEA, the OEA/PEA and the DHEA/AEA ratios were associated with cognitive changes in a sex- and APOE-dependent fashion. These results support the modulation of the endocannabinoid system as a potential therapeutic approach to prevent cognitive decline in at-risk populations.

Trial registration: ISRCTN89898870.

背景:地中海饮食(MedDiet)在预防与年龄有关的认知能力下降和调节血浆中的内源性大麻素(eCBs)和 N-酰乙醇胺(NAEs,或 eCB 类化合物)浓度方面已被证明具有疗效。我们推测 eCBs 和 NAEs 将成为 MedDiet 干预的生物标志物,并与认知反应有关,因此我们根据可能影响 eCBs 和认知表现的性别和载脂蛋白 E(APOE)基因型对这种关系进行了调查:这是一项前瞻性队列研究,从 PREDIMED-Plus-Cognition 子研究中招募了 102 名参与者(53.9% 为女性,18.8% 为 APOE-ɛ4 携带者,年龄为 65.6 ± 4.5 岁),他们都来自巴塞罗那德尔马医院研究所(Hospital del Mar Research Institute)。他们均患有代谢综合征和超重/肥胖症(PREDIMED-Plus 的纳入标准),基线认知能力正常(本子研究的纳入标准)。在基线及 1 年和 3 年后进行了全面的神经心理学测试。此外,还监测了 eCB 和 NAE 的血浆浓度,包括 2-丙烯酰甘油 (2-AG)、anandamide (AEA)、油酰乙醇酰胺 (OEA)、棕榈酰乙醇酰胺 (PEA) 和 N-二十二碳六烯乙醇胺 (DHEA)。根据性别(粗略模型)、性别(调整模型)和 APOE 基因型评估了基线认知、认知变化以及 eCBs/NAEs 与认知之间的关联:基线时,男性的执行功能和整体认知能力优于女性(性别差异的效应大小为-0.49,p = 0.015;和-0.42,p = 0.036);然而,在性别差异模型中,这些差异变得不显著。经过 3 年的 MedDiet 干预后,参与者的记忆力和整体认知能力略有改善。然而,与女性相比,男性的记忆力变化更大(Cohen's d 为 0.40 vs. 0.25;p = 0.017)。在男性和 APOE-ε4 携带者中,2-AG 浓度与基线认知和认知变化成反比,而在女性中,认知变化与 DHEA 和 DHEA/AEA 比率的变化成正比。在男性中,OEA/AEA 和 OEA/PEA 比率的变化与认知变化呈正相关:结论:"健康饮食 "改善了参与者的认知能力,但其效果很小,且受女性性别的负面影响。2-AG、DHEA、OEA/AEA、OEA/PEA 和 DHEA/AEA 比率的变化与认知能力的变化相关,且与性别和 APOE 有关。这些结果支持将调节内源性大麻素系统作为预防高危人群认知能力下降的潜在治疗方法:试验注册:ISRCTN89898870。
{"title":"Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention.","authors":"Natalia Soldevila-Domenech, Beatriz Fagundo, Aida Cuenca-Royo, Laura Forcano, Maria Gomis-González, Anna Boronat, Antoni Pastor, Olga Castañer, Maria Dolores Zomeño, Albert Goday, Mara Dierssen, Khashayar Baghizadeh Hosseini, Emilio Ros, Dolores Corella, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Fernando Fernández-Aranda, Montserrat Fitó, Rafael de la Torre","doi":"10.1186/s12937-024-00966-w","DOIUrl":"10.1186/s12937-024-00966-w","url":null,"abstract":"<p><strong>Background: </strong>The Mediterranean diet (MedDiet) has demonstrated efficacy in preventing age-related cognitive decline and modulating plasma concentrations of endocannabinoids (eCBs) and N-acylethanolamines (NAEs, or eCB-like compounds), which are lipid mediators involved in multiple neurological disorders and metabolic processes. Hypothesizing that eCBs and NAEs will be biomarkers of a MedDiet intervention and will be related to the cognitive response, we investigated this relationship according to sex and apolipoprotein E (APOE) genotype, which may affect eCBs and cognitive performance.</p><p><strong>Methods: </strong>This was a prospective cohort study of 102 participants (53.9% women, 18.8% APOE-ɛ4 carriers, aged 65.6 ± 4.5 years) from the PREDIMED-Plus-Cognition substudy, who were recruited at the Hospital del Mar Research Institute (Barcelona). All of them presented metabolic syndrome plus overweight/obesity (inclusion criteria of the PREDIMED-Plus) and normal cognitive performance at baseline (inclusion criteria of this substudy). A comprehensive battery of neuropsychological tests was administered at baseline and after 1 and 3 years. Plasma concentrations of eCBs and NAEs, including 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and N-docosahexaenoylethanolamine (DHEA), were also monitored. Baseline cognition, cognitive changes, and the association between eCBs/NAEs and cognition were evaluated according to gender (crude models), sex (adjusted models), and APOE genotype.</p><p><strong>Results: </strong>At baseline, men had better executive function and global cognition than women (the effect size of gender differences was - 0.49, p = 0.015; and - 0.42, p = 0.036); however, these differences became nonsignificant in models of sex differences. After 3 years of MedDiet intervention, participants exhibited modest improvements in memory and global cognition. However, greater memory changes were observed in men than in women (Cohen's d of 0.40 vs. 0.25; p = 0.017). In men and APOE-ε4 carriers, 2-AG concentrations were inversely associated with baseline cognition and cognitive changes, while in women, cognitive changes were positively linked to changes in DHEA and the DHEA/AEA ratio. In men, changes in the OEA/AEA and OEA/PEA ratios were positively associated with cognitive changes.</p><p><strong>Conclusions: </strong>The MedDiet improved participants' cognitive performance but the effect size was small and negatively influenced by female sex. Changes in 2-AG, DHEA, the OEA/AEA, the OEA/PEA and the DHEA/AEA ratios were associated with cognitive changes in a sex- and APOE-dependent fashion. These results support the modulation of the endocannabinoid system as a potential therapeutic approach to prevent cognitive decline in at-risk populations.</p><p><strong>Trial registration: </strong>ISRCTN89898870.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of weight-adjusted waist index with all-cause mortality among non-Asian individuals: a national population-based cohort study. 体重调整后腰围指数与非亚洲人全因死亡率的关系:一项基于全国人口的队列研究。
IF 5.4 2区 医学 Q1 Medicine Pub Date : 2024-06-12 DOI: 10.1186/s12937-024-00947-z
Ting Cao, Ruijie Xie, Jiusong Wang, Meimei Xiao, Haiyang Wu, Xiaozhu Liu, Songlin Xie, Yanming Chen, Mingjiang Liu, Ya Zhang

Introduction: The Weight-Adjusted Waist Index (WWI) is a new indicator of obesity that is associated with all-cause mortality in Asian populations. Our study aimed to investigate the linear and non-linear associations between WWI and all-cause mortality in non-Asian populations in the United States, and whether WWI was superior to traditional obesity indicators as a predictor of all-cause mortality.

Methods: We conducted a cohort study using data from the 2011-2018 National Health and Nutrition Examination Survey (NHANES), involving 18,592 participants. We utilized Cox proportional hazard models to assess the association between WWI, BMI, WC, and the risk of all-cause mortality, and performed subgroup analyses and interaction tests. We also employed a receiver operating characteristics (ROC) curve study to evaluate the effectiveness of WWI, BMI, and WC in predicting all-cause mortality.

Results: After adjusting for confounders, WWI, BMI, and WC were positively associated with all-cause mortality. The performance of WWI, BMI, and WC in predicting all-cause mortality yielded AUCs of 0.697, 0.524, and 0.562, respectively. The data also revealed a U-shaped relationship between WWI and all-cause mortality. Race and cancer modified the relationship between WWI and all-cause mortality, with the relationship being negatively correlated in African Americans and cancer patients.

Conclusions: In non-Asian populations in the United States, there is a U-shaped relationship between WWI and all-cause mortality, and WWI outperforms BMI and WC as a predictor of all-cause mortality. These findings may contribute to a better understanding and prediction of the relationship between obesity and mortality, and provide support for effective obesity management strategies.

简介体重调整腰围指数(WWI)是一项新的肥胖指标,与亚裔人群的全因死亡率有关。我们的研究旨在调查WWI与美国非亚裔人群全因死亡率之间的线性和非线性关系,以及WWI作为全因死亡率的预测指标是否优于传统肥胖指标:我们利用 2011-2018 年美国国家健康与营养调查(NHANES)的数据开展了一项队列研究,共涉及 18,592 名参与者。我们利用 Cox 比例危险模型评估了 WWI、BMI、WC 与全因死亡风险之间的关联,并进行了亚组分析和交互检验。我们还采用了接收器操作特征(ROC)曲线研究来评估WWI、BMI和WC在预测全因死亡率方面的有效性:结果:调整混杂因素后,WWI、BMI 和 WC 与全因死亡率呈正相关。WWI、BMI 和 WC 预测全因死亡率的 AUC 分别为 0.697、0.524 和 0.562。数据还显示,WWI 与全因死亡率之间呈 U 型关系。种族和癌症改变了WWI与全因死亡率之间的关系,非裔美国人和癌症患者的WWI与全因死亡率呈负相关:结论:在美国非亚裔人群中,WWI 与全因死亡率之间呈 U 型关系,WWI 作为全因死亡率的预测指标优于 BMI 和 WC。这些发现有助于更好地理解和预测肥胖与死亡率之间的关系,并为有效的肥胖管理策略提供支持。
{"title":"Association of weight-adjusted waist index with all-cause mortality among non-Asian individuals: a national population-based cohort study.","authors":"Ting Cao, Ruijie Xie, Jiusong Wang, Meimei Xiao, Haiyang Wu, Xiaozhu Liu, Songlin Xie, Yanming Chen, Mingjiang Liu, Ya Zhang","doi":"10.1186/s12937-024-00947-z","DOIUrl":"10.1186/s12937-024-00947-z","url":null,"abstract":"<p><strong>Introduction: </strong>The Weight-Adjusted Waist Index (WWI) is a new indicator of obesity that is associated with all-cause mortality in Asian populations. Our study aimed to investigate the linear and non-linear associations between WWI and all-cause mortality in non-Asian populations in the United States, and whether WWI was superior to traditional obesity indicators as a predictor of all-cause mortality.</p><p><strong>Methods: </strong>We conducted a cohort study using data from the 2011-2018 National Health and Nutrition Examination Survey (NHANES), involving 18,592 participants. We utilized Cox proportional hazard models to assess the association between WWI, BMI, WC, and the risk of all-cause mortality, and performed subgroup analyses and interaction tests. We also employed a receiver operating characteristics (ROC) curve study to evaluate the effectiveness of WWI, BMI, and WC in predicting all-cause mortality.</p><p><strong>Results: </strong>After adjusting for confounders, WWI, BMI, and WC were positively associated with all-cause mortality. The performance of WWI, BMI, and WC in predicting all-cause mortality yielded AUCs of 0.697, 0.524, and 0.562, respectively. The data also revealed a U-shaped relationship between WWI and all-cause mortality. Race and cancer modified the relationship between WWI and all-cause mortality, with the relationship being negatively correlated in African Americans and cancer patients.</p><p><strong>Conclusions: </strong>In non-Asian populations in the United States, there is a U-shaped relationship between WWI and all-cause mortality, and WWI outperforms BMI and WC as a predictor of all-cause mortality. These findings may contribute to a better understanding and prediction of the relationship between obesity and mortality, and provide support for effective obesity management strategies.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between serum vitamin D level and Graves' disease: a systematic review and meta-analysis. 血清维生素 D 水平与巴塞杜氏病的关系:系统回顾与荟萃分析。
IF 5.4 2区 医学 Q1 Medicine Pub Date : 2024-06-07 DOI: 10.1186/s12937-024-00960-2
Boxian Pang, Leyang Li, Xin Liu, Zhengmin Cao, Tieliang Pang, Qiuhong Wang, Junping Wei

Objective: This meta-analysis aims to analyze the relationship between serum vitamin D (VD) levels and Graves' disease (GD).

Methods: We conducted a search for publications on VD and GD in the English language. Our search encompassed databases such as PubMed, Embase, Web of Science, and the Cochrane Library, covering publications available through August 2023. A meta-analysis was performed using Cochrane RevMan 5.4 software. The standardized mean difference (SMD) and 95% confidence interval (CI) were used for outcome calculation. We used R software to test for publication bias.

Results: Twelve studies were selected, comprising 937 (22.4%) cases with GD and 3254 (77.6%) controls. The overall meta-analysis revealed that patients with GD are significantly more likely to have low VD levels (SMD = - 0.66; 95% CI: -1.05, - 0.27; p = 0.001) than those in the control group. Egger's test results indicated no publication bias (p = 0.0791). These studies exhibited a high degree of heterogeneity (chi-square = 205.86, p < 0.00001; I2 = 95%). Subgroup analysis was conducted based on assay method, geographic location, and mean age of the case group to explore the heterogeneity sources. Assay methods and geographic locations were identified as potential heterogeneity sources. Based on the mean age, there were no statistically significant differences found in the subgroup analysis of the included studies.

Conclusion: There is promising evidence that low serum VD levels may increase the risk of GD. Further rigorous and long-term trials are needed to explore the role of VD in the onset and treatment of GD.

目的本荟萃分析旨在分析血清维生素 D(VD)水平与巴塞杜氏病(GD)之间的关系:我们检索了有关维生素 D 和巴塞杜氏病的英文文献。我们的搜索范围包括 PubMed、Embase、Web of Science 和 Cochrane Library 等数据库,涵盖截至 2023 年 8 月的出版物。我们使用 Cochrane RevMan 5.4 软件进行了荟萃分析。结果计算采用标准化平均差 (SMD) 和 95% 置信区间 (CI)。我们使用 R 软件检验发表偏倚:结果:共选取了 12 项研究,包括 937 例(22.4%)GD 患者和 3254 例(77.6%)对照组。总体荟萃分析显示,与对照组相比,GD 患者的 VD 水平明显偏低(SMD = - 0.66; 95% CI: -1.05, - 0.27; p = 0.001)。Egger检验结果显示无发表偏倚(P = 0.0791)。这些研究显示出高度异质性(chi-square = 205.86,p 2 = 95%)。我们根据检测方法、地理位置和病例组的平均年龄进行了分组分析,以探索异质性的来源。检测方法和地理位置被确定为潜在的异质性来源。根据平均年龄,纳入研究的亚组分析未发现有统计学意义的差异:有证据表明,血清 VD 水平过低可能会增加罹患 GD 的风险。需要进一步进行严格和长期的试验,以探讨 VD 在 GD 发病和治疗中的作用。
{"title":"Association between serum vitamin D level and Graves' disease: a systematic review and meta-analysis.","authors":"Boxian Pang, Leyang Li, Xin Liu, Zhengmin Cao, Tieliang Pang, Qiuhong Wang, Junping Wei","doi":"10.1186/s12937-024-00960-2","DOIUrl":"10.1186/s12937-024-00960-2","url":null,"abstract":"<p><strong>Objective: </strong>This meta-analysis aims to analyze the relationship between serum vitamin D (VD) levels and Graves' disease (GD).</p><p><strong>Methods: </strong>We conducted a search for publications on VD and GD in the English language. Our search encompassed databases such as PubMed, Embase, Web of Science, and the Cochrane Library, covering publications available through August 2023. A meta-analysis was performed using Cochrane RevMan 5.4 software. The standardized mean difference (SMD) and 95% confidence interval (CI) were used for outcome calculation. We used R software to test for publication bias.</p><p><strong>Results: </strong>Twelve studies were selected, comprising 937 (22.4%) cases with GD and 3254 (77.6%) controls. The overall meta-analysis revealed that patients with GD are significantly more likely to have low VD levels (SMD = - 0.66; 95% CI: -1.05, - 0.27; p = 0.001) than those in the control group. Egger's test results indicated no publication bias (p = 0.0791). These studies exhibited a high degree of heterogeneity (chi-square = 205.86, p < 0.00001; I<sup>2</sup> = 95%). Subgroup analysis was conducted based on assay method, geographic location, and mean age of the case group to explore the heterogeneity sources. Assay methods and geographic locations were identified as potential heterogeneity sources. Based on the mean age, there were no statistically significant differences found in the subgroup analysis of the included studies.</p><p><strong>Conclusion: </strong>There is promising evidence that low serum VD levels may increase the risk of GD. Further rigorous and long-term trials are needed to explore the role of VD in the onset and treatment of GD.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gardening and subjective cognitive decline: a cross-sectional study and mediation analyses of 136,748 adults aged 45+ years. 园艺与主观认知能力下降:对 136 748 名 45 岁以上成年人进行的横断面研究和中介分析。
IF 5.4 2区 医学 Q1 Medicine Pub Date : 2024-06-04 DOI: 10.1186/s12937-024-00959-9
Kaiyue Wang, Yaqi Li, Xiao Chen, Susan Veldheer, Chen Wang, Han Wang, Liang Sun, Xiang Gao

Background: Given the benefits of gardening for physical and psychological health, we explored whether gardening was associated with lower risks of subjective cognitive decline (SCD), a precursor of dementia, and SCD-related functional limitations.

Methods: Included in this cross-sectional study were 136,748 participants aged 45 + years old from the Behavioral Risk Factor Surveillance System 2019 survey, who were then categorized into three groups according to self-reported exercise status: non-exercisers, gardeners, and other exercisers. SCD was assessed via a questionnaire, and SCD-related functional limitations were referred to as having difficulties in engaging in household or social activities due to SCD. The odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the associations of gardening with SCD and SCD-related functional limitations, adjusted for age, sex, socioeconomic status, lifestyle factors, and health status. Mediation analyses were conducted to examine whether the observed association between gardening and SCD was mediated by energy expenditure (MET-hours/week), depression status, and consumption of fruits and vegetables.

Results: Overall, 11.1% and 5.4% of participants self-reported experiencing SCD and SCD-related functional limitations, respectively. The adjusted OR for gardeners vs. non-exercisers, was 0.72 (95% CI 0.62-0.83) for SCD and 0.57 (95% CI 0.44-0.73) for SCD-related functional limitations. The observed association between gardening and SCD was explained by higher energy expenditure (39.0%), lower likelihood of having depression (21.5%), and higher consumption of fruits and vegetables (3.4%) (P<0.05 for all). Similar patterns were observed for SCD-related functional limitations.

Conclusion: In this nationally representative sample, gardening was associated with better cognitive status, which may be mainly attributed to better depression status and energy expenditure.

背景:鉴于园艺对身体和心理健康的益处,我们探讨了园艺是否与较低的主观认知能力下降(SCD)风险(痴呆症的前兆)以及与SCD相关的功能限制有关:这项横断面研究的对象是行为风险因素监测系统 2019 年调查中年龄在 45 岁以上的 136 748 名参与者,然后根据自我报告的运动状况将他们分为三组:非运动者、园艺工作者和其他运动者。SCD通过问卷调查进行评估,与SCD相关的功能限制指的是由于SCD而在从事家庭或社会活动时遇到困难。计算了几率比(OR)和 95% 的置信区间(CI),以评估园艺与 SCD 和 SCD 相关功能限制的关系,并对年龄、性别、社会经济地位、生活方式因素和健康状况进行了调整。研究人员还进行了中介分析,以考察所观察到的园艺与 SCD 之间的关系是否受到能量消耗(MET-小时/周)、抑郁状况以及水果和蔬菜摄入量的影响:总体而言,分别有 11.1% 和 5.4% 的参与者自述经历过 SCD 和与 SCD 相关的功能限制。园艺者与非运动者相比,SCD 的调整 OR 为 0.72(95% CI 0.62-0.83),SCD 相关功能限制的调整 OR 为 0.57(95% CI 0.44-0.73)。所观察到的园艺与 SCD 之间的关联可通过更高的能量消耗(39.0%)、更低的抑郁可能性(21.5%)以及更高的水果和蔬菜消耗量(3.4%)来解释(PC 结论:在这个具有全国代表性的样本中,园艺与较好的认知状况有关,这可能主要归因于较好的抑郁状况和能量消耗。
{"title":"Gardening and subjective cognitive decline: a cross-sectional study and mediation analyses of 136,748 adults aged 45+ years.","authors":"Kaiyue Wang, Yaqi Li, Xiao Chen, Susan Veldheer, Chen Wang, Han Wang, Liang Sun, Xiang Gao","doi":"10.1186/s12937-024-00959-9","DOIUrl":"10.1186/s12937-024-00959-9","url":null,"abstract":"<p><strong>Background: </strong>Given the benefits of gardening for physical and psychological health, we explored whether gardening was associated with lower risks of subjective cognitive decline (SCD), a precursor of dementia, and SCD-related functional limitations.</p><p><strong>Methods: </strong>Included in this cross-sectional study were 136,748 participants aged 45 + years old from the Behavioral Risk Factor Surveillance System 2019 survey, who were then categorized into three groups according to self-reported exercise status: non-exercisers, gardeners, and other exercisers. SCD was assessed via a questionnaire, and SCD-related functional limitations were referred to as having difficulties in engaging in household or social activities due to SCD. The odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the associations of gardening with SCD and SCD-related functional limitations, adjusted for age, sex, socioeconomic status, lifestyle factors, and health status. Mediation analyses were conducted to examine whether the observed association between gardening and SCD was mediated by energy expenditure (MET-hours/week), depression status, and consumption of fruits and vegetables.</p><p><strong>Results: </strong>Overall, 11.1% and 5.4% of participants self-reported experiencing SCD and SCD-related functional limitations, respectively. The adjusted OR for gardeners vs. non-exercisers, was 0.72 (95% CI 0.62-0.83) for SCD and 0.57 (95% CI 0.44-0.73) for SCD-related functional limitations. The observed association between gardening and SCD was explained by higher energy expenditure (39.0%), lower likelihood of having depression (21.5%), and higher consumption of fruits and vegetables (3.4%) (P<0.05 for all). Similar patterns were observed for SCD-related functional limitations.</p><p><strong>Conclusion: </strong>In this nationally representative sample, gardening was associated with better cognitive status, which may be mainly attributed to better depression status and energy expenditure.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet quality from mid to late life and its association with physical frailty in late life in a cohort of Chinese adults. 中国成年人队列中从中年到晚年的饮食质量及其与晚年身体虚弱的关系。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-04 DOI: 10.1186/s12937-024-00964-y
Jun S Lai, Kevin Y Chua, Huiqi Li, Woon-Puay Koh

Background: It is unclear if improving diet quality after midlife could reduce the risk of physical frailty at late life. We aimed to associate changes in diet quality after midlife with physical frailty at late life.

Methods: Diet quality in 12,580 participants from the Singapore Chinese Health Study was assessed with the Dietary Approaches to Stop Hypertension (DASH) scores at baseline (1993-1998; mean age 53 years) and follow-up 3 (2014-2016; mean age 73 years). Physical frailty was assessed using the modified Cardiovascular Health Study phenotype at follow-up 3. Multivariable logistic regressions examined associations between DASH scores and physical frailty.

Results: Comparing participants in extreme quartiles of DASH scores, the odds ratios (OR) [95% confidence interval (CI)] for physical frailty were 0.85 (0.73,0.99) at baseline and 0.49 (0.41, 0.58) at follow-up 3. Compared to participants with consistently low DASH scores, participants with consistently high scores (OR 0.74, 95% CI: 0.59, 0.94) and those with > 10% increase in scores (OR 0.78, 95% CI: 0.64, 0.95) had lower odds of frailty. Compared to those in the lowest DASH tertiles at both time-points, significantly lower odds of physical frailty were observed in those who were in the highest DASH tertiles at both time points [0.59 (0.48, 0.73)], and in those who improved their scores from the lowest [0.68 (0.51, 0.91)] or second tertile at baseline [0.61 (0.48, 0.76)] to the highest tertile at follow-up 3.

Conclusions: Maintaining a high diet quality or a substantial improvement in diet quality after midlife could lower the risk of physical frailty at late life.

背景:目前尚不清楚中年以后饮食质量的改善能否降低晚年身体虚弱的风险。我们的目的是将中年后饮食质量的变化与晚年身体虚弱联系起来:方法:在基线(1993-1998 年;平均年龄 53 岁)和随访 3(2014-2016 年;平均年龄 73 岁)期间,采用饮食疗法阻止高血压(DASH)评分对新加坡华人健康研究(Singapore Chinese Health Study)的 12,580 名参与者的饮食质量进行了评估。在随访 3 期,采用改良的心血管健康研究表型评估身体虚弱程度。多变量逻辑回归检验了DASH评分与身体虚弱之间的关联:结果:与 DASH 评分处于极端四分位数的参与者相比,基线时身体虚弱的几率比(OR)[95% 置信区间(CI)]为 0.85(0.73,0.99),随访 3 时为 0.49(0.41,0.58)。与DASH评分一直较低的参与者相比,评分一直较高的参与者(OR 0.74,95% CI:0.59,0.94)和评分增加>10%的参与者(OR 0.78,95% CI:0.64,0.95)出现虚弱的几率较低。与在两个时间点均处于最低DASH三分位数的人群相比,在两个时间点均处于最高DASH三分位数的人群[0.59 (0.48, 0.73)],以及在随访3时得分从基线时的最低[0.68 (0.51, 0.91)]或第二三分位数[0.61 (0.48, 0.76)]提高到最高三分位数的人群中,身体虚弱的几率明显较低:结论:保持较高的饮食质量或在中年后大幅提高饮食质量可降低晚年身体虚弱的风险。
{"title":"Diet quality from mid to late life and its association with physical frailty in late life in a cohort of Chinese adults.","authors":"Jun S Lai, Kevin Y Chua, Huiqi Li, Woon-Puay Koh","doi":"10.1186/s12937-024-00964-y","DOIUrl":"10.1186/s12937-024-00964-y","url":null,"abstract":"<p><strong>Background: </strong>It is unclear if improving diet quality after midlife could reduce the risk of physical frailty at late life. We aimed to associate changes in diet quality after midlife with physical frailty at late life.</p><p><strong>Methods: </strong>Diet quality in 12,580 participants from the Singapore Chinese Health Study was assessed with the Dietary Approaches to Stop Hypertension (DASH) scores at baseline (1993-1998; mean age 53 years) and follow-up 3 (2014-2016; mean age 73 years). Physical frailty was assessed using the modified Cardiovascular Health Study phenotype at follow-up 3. Multivariable logistic regressions examined associations between DASH scores and physical frailty.</p><p><strong>Results: </strong>Comparing participants in extreme quartiles of DASH scores, the odds ratios (OR) [95% confidence interval (CI)] for physical frailty were 0.85 (0.73,0.99) at baseline and 0.49 (0.41, 0.58) at follow-up 3. Compared to participants with consistently low DASH scores, participants with consistently high scores (OR 0.74, 95% CI: 0.59, 0.94) and those with > 10% increase in scores (OR 0.78, 95% CI: 0.64, 0.95) had lower odds of frailty. Compared to those in the lowest DASH tertiles at both time-points, significantly lower odds of physical frailty were observed in those who were in the highest DASH tertiles at both time points [0.59 (0.48, 0.73)], and in those who improved their scores from the lowest [0.68 (0.51, 0.91)] or second tertile at baseline [0.61 (0.48, 0.76)] to the highest tertile at follow-up 3.</p><p><strong>Conclusions: </strong>Maintaining a high diet quality or a substantial improvement in diet quality after midlife could lower the risk of physical frailty at late life.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Nutrition Journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1