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Associations between maternal diet, family eating habits and preschool children's dietary patterns: insights from the UPBEAT trial. 母亲饮食、家庭饮食习惯与学龄前儿童饮食模式之间的关系:UPBEAT 试验的启示。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-28 DOI: 10.1186/s12937-024-01023-2
Veronica Luque, Fernanda Mucarzel, Anna Hertogs, Paul T Seed, Angela C Flynn, Lucilla Poston, Kathryn V Dalrymple

Background: Dietary behaviours in early life often track across the life course, influencing the development of adverse health outcomes such as obesity and cardiovascular disease. This study aimed to explore the between dietary patterns (DP) in preschool children and maternal DP and family eating habits.

Methods: We conducted a secondary analysis of 488 mother-child pairs from the UK pregnancy Better Eating and Activity Trial (UPBEAT) at 3-year follow-up. Previously published DP from mothers and children (derived from food-frequency questionnaires and exploratory factor analysis) were used. Mothers' DP were "Fruits-Vegetables", "African-Caribbean", "Processed and Snacks", and children's DP were "Prudent", "Processed-Snacking", and "African-Caribbean". Family meal environments were evaluated using a 5-point Likert scale.

Results: Linear regression models revealed that child's prudent pattern was positively associated with maternal Fruits-Vegetables (B = 0.18 (0.08, 0.27)), Snacks patterns (B = 0.10 (0.01, 0.18)), and eating the same foods during meals (B = 0.25 (0.07, 0.43)). Child's Processed-Snacking pattern was directly associated with maternal Processed (B = 0.22 (0.13, 0.30)) and Snacks (B = 0.27 (0.18, 0.36)) patterns, receiving food as reward (B = 0.22 (0.04, 0.39)) and watching TV during meals (B = 0.27 (0.09, 0.45)). Finally, the child African-Caribbean pattern was directly associated with that from the mother (B = 0.41 (0.33, 0.50)) and watching TV during meals (B = 0.15 (0.09, 0.30)), and inversely associated with maternal processed (B=-0.09 (-0.17, -0.02)) and snacking (B=-0.08 (-0.15, -0.04)) patterns.

Conclusions: Unhealthy dietary patterns in childhood are directly linked to similar maternal patterns and family meal behaviours, such as television viewing and food rewards. These findings highlight targetable behaviours for public health interventions.

背景:生命早期的饮食行为往往贯穿整个生命过程,影响肥胖和心血管疾病等不良健康后果的发展。本研究旨在探讨学龄前儿童的饮食模式(DP)与母亲的饮食模式和家庭饮食习惯之间的关系:我们对英国妊娠期更佳饮食和活动试验(UPBEAT)中的 488 对母子进行了为期 3 年的二次分析。我们采用了之前公布的母亲和孩子的饮食习惯(通过食物频率问卷调查和探索性因素分析得出)。母亲的饮食习惯是 "水果-蔬菜"、"非洲-加勒比"、"加工食品和零食",儿童的饮食习惯是 "谨慎"、"加工食品-零食 "和 "非洲-加勒比"。家庭膳食环境采用 5 点李克特量表进行评估:线性回归模型显示,儿童的谨慎模式与母亲的水果-蔬菜(B = 0.18 (0.08, 0.27))、零食模式(B = 0.10 (0.01, 0.18))和进餐时吃同样的食物(B = 0.25 (0.07, 0.43))呈正相关。儿童的加工零食模式与母亲的加工(B = 0.22 (0.13, 0.30))和零食(B = 0.27 (0.18, 0.36))模式、接受食物作为奖励(B = 0.22 (0.04, 0.39))和进餐时看电视(B = 0.27 (0.09, 0.45))直接相关。最后,非裔加勒比海儿童的饮食模式与母亲的饮食模式(B = 0.41 (0.33, 0.50))和吃饭时看电视(B = 0.15 (0.09, 0.30))直接相关,而与母亲加工(B=-0.09 (-0.17, -0.02))和吃零食(B=-0.08 (-0.15, -0.04))的饮食模式成反比:结论:儿童时期不健康的饮食模式与类似的母亲模式和家庭用餐行为(如看电视和食物奖励)直接相关。这些发现凸显了公共卫生干预的目标行为。
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引用次数: 0
Correction: Olfactory performance and odor liking are negatively associated with food neophobia in children aged between 3 and 9 years. 更正:3至9岁儿童的嗅觉表现和气味喜好与食物新恐惧症呈负相关。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-27 DOI: 10.1186/s12937-024-01015-2
Agnieszka Sorokowska, Dominika Chabin, Aleksandra Kamieńska, Sabina Barszcz, Katarzyna Byczyńska, Klaudia Fuławka, Arkadiusz Urbanek, Anna Oleszkiewicz
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引用次数: 0
Dietary pattern trajectories in early childhood and their associations with patterns of maternal feeding practices in a multi-ethnic Asian cohort. 一个多民族亚洲队列中幼儿期的饮食模式轨迹及其与母亲喂养方式的关系。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-20 DOI: 10.1186/s12937-024-01012-5
Geeta Appannah, Jia Ying Toh, Jun Shi Lai, Heng Yaw Yong, Zalilah Mohd Shariff, Mya Thway Tint, Wen Lun Yuan, Wei Wei Pang, Keith M Godfrey, Kok Hian Tan, Fabian Yap, Yung Seng Lee, Johan G Eriksson, Mary F F Chong

Background: Maternal feeding practices play a major role in children's dietary intakes. However, there is limited data on the associations between trajectories of dietary patterns (DPs) and patterns of maternal feeding practices during early childhood.

Methods: Using data from a multi-ethnic Asian cohort study, namely the Growing Up in Singapore Towards healthy Outcomes (GUSTO), dietary intakes were measured using Food Frequency Questionnaires in children at 18 months, 5 and 7 years of age. Maternal feeding practices were assessed using validated questionnaires at 15 months, 3 and 5 years of age. Principal component analysis was used to derive 2 major DPs at all time-points as well as patterns of maternal feeding practices. Group-based trajectory modelling was used to identify trajectory groups for the derived DPs. Multivariable logistic regression examined associations between patterns of maternal feeding practices and DP trajectory groups.

Results: Two DPs, namely the 'healthy' and 'less healthy' were consistently derived at 18 months, 5 and 7 years of age. From each DP, 2 stable DP trajectory groups were further identified between 18 months and 7 years of age. For the 'healthy' DP trajectory, majority of the children (Group 1) formed a consistent average adherence trajectory group (91.8%) while the remaining children (Group 2) showed a higher but decreasing adherence (8.2%) to this DP. For the 'less healthy' DP trajectory, most children (Group 1) formed a consistent average adherence trajectory (95.5%), while the remainder (Group 2) showed consistent higher adherence to this 'less healthy' DP (4.5%). Two patterns of maternal feeding practices were derived and labelled as 'structured with autonomy support' and 'coercive control', respectively, at ages 15 months, 3 and 5 years. Children whose mothers showed high adherence to the structured with autonomy support feeding practices at age 5 years were significantly more likely to be associated with the higher but decreasing 'healthy' DP trajectory group [OR = 3.62 (95% CI: 1.64, 7.99)].

Conclusions: A small number of children in this multi-ethnic study showed high adherence to the 'healthy' or 'less healthy' DP trajectory groups, respectively, while the majority showed average adherence to either of these trajectories. The positive association between structured with autonomy support maternal feeding practices and higher z-scores for the healthy DP trajectory highlights the importance of guiding parents on appropriate feeding practices.

背景:母亲的喂养方式对儿童的膳食摄入量起着重要作用。然而,有关幼儿期膳食模式(DPs)轨迹与母亲喂养方式之间关系的数据却很有限:方法:利用一项多种族亚洲队列研究(即 "在新加坡成长,迈向健康结果"(GUSTO))的数据,使用食物频率问卷调查法测量儿童在 18 个月、5 岁和 7 岁时的膳食摄入量。对 15 个月、3 岁和 5 岁儿童的母亲喂养方式则采用有效问卷进行评估。采用主成分分析法得出所有时间点的两个主要数据集以及母亲喂养方式的模式。基于群体的轨迹模型被用来确定衍生出的DPs的轨迹群体。多变量逻辑回归检验了产妇喂养方式与DP轨迹组之间的关联:结果:在 18 个月、5 岁和 7 岁时,持续得出两个 DP,即 "健康 "和 "不太健康"。在每个DP中,进一步确定了18个月至7岁期间两个稳定的DP轨迹组。就 "健康 "DP轨迹而言,大多数儿童(第 1 组)形成了一个稳定的平均坚持率轨迹组(91.8%),而其余儿童(第 2 组)对这一DP的坚持率较高,但呈下降趋势(8.2%)。至于 "不太健康 "的喂养模式轨迹,大多数儿童(第 1 组)形成了一致的平均喂养模式轨迹(95.5%),而其余儿童(第 2 组)对这一 "不太健康 "的喂养模式的依从性较高(4.5%)。在 15 个月、3 岁和 5 岁时,得出了两种母亲喂养方式,并分别标记为 "结构化自主支持 "和 "强制控制"。在5岁时,如果母亲高度坚持 "有自主支持的结构化喂养 "方式,则其子女明显更有可能属于 "健康 "DP轨迹较高但不断下降的组别[OR = 3.62 (95% CI: 1.64, 7.99)]:在这项多种族研究中,少数儿童分别表现出与 "健康 "或 "较不健康 "DP轨迹组的高度一致性,而大多数儿童则表现出与这两种轨迹的一般一致性。有自主支持的结构化母亲喂养方式与较高的健康DP轨迹z-分数之间存在正相关,这凸显了指导父母采取适当喂养方式的重要性。
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引用次数: 0
Correction: Consumption of different types of meat and the risk of chronic limb-threatening ischemia: the Singapore Chinese Health Study. 更正:食用不同种类的肉类与慢性肢体缺血风险:新加坡华人健康研究。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-19 DOI: 10.1186/s12937-024-01014-3
Ariel Fangting Ying, Mohammad Talaei, Derek John Hausenloy, Woon-Puay Koh
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引用次数: 0
Adherence to the EAT-Lancet index is associated with lower diet costs in the Mexican population. 遵守 EAT-Lancet 指数可降低墨西哥人的饮食成本。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-19 DOI: 10.1186/s12937-024-01002-7
Tania C Aburto, Juan Carlos Salgado, Sonia Rodríguez-Ramírez, Juan A Rivera, Simon Barquera, Carolina Batis

Background: Poor diet quality contributes to morbidity and mortality and affects environmental sustainability. The EAT-Lancet reference diet offers a healthy and sustainable solution. This study aimed to estimate the association between diet cost and dietary quality, measured with an EAT-Lancet Index.

Methods: An EAT-Lancet index was adapted to assess adherence to this dietary pattern from 24-h recalls data from the 2012 and 2016 Mexican National Health and Nutrition Surveys (n = 14,242). Prices were obtained from the Consumer Price Index. We dichotomized cost at the median (into low- and high-cost) and compared the EAT-Lancet index scores. We also used multivariate linear regression models to explore the association between diet cost and diet quality.

Results: Individuals consuming a low-cost diet had a higher EAT-Lancet score than those consuming a high-cost diet (20.3 vs. 19.4 from a possible scale of 0 to 42; p < 0.001) due to a lower intake of beef and lamb, pork, poultry, dairy, and added sugars. We found that for each one-point increase in the EAT-Lancet score, there was an average decrease of MXN$0.4 in the diet cost (p < 0.001). This association was only significant among low- and middle-SES individuals.

Conclusions: Contrary to evidence from high-income countries, this study shows that in Mexico, adhering to the EAT-Lancet reference diet is associated with lower dietar costs, particularly in lower SES groups. These findings suggest the potential for broader implementation of healthier diets without increasing the financial burden.

背景:饮食质量差会导致发病率和死亡率,并影响环境的可持续发展。EAT-Lancet 参考膳食提供了一种健康且可持续的解决方案。本研究旨在通过 EAT-Lancet 指数估算饮食成本与饮食质量之间的关系:根据 2012 年和 2016 年墨西哥全国健康与营养调查(n = 14,242 人)中的 24 小时回忆数据,对 EAT-Lancet 指数进行了调整,以评估该饮食模式的坚持情况。价格来自消费者价格指数。我们按中位数对成本进行了二分(分为低成本和高成本),并比较了 EAT-Lancet 指数得分。我们还使用多元线性回归模型来探讨饮食成本与饮食质量之间的关系:结果:与高收入人群相比,低成本饮食人群的 EAT-Lancet 得分更高(从 0 到 42 的评分中,20.3 分对 19.4 分;p 结论:与高收入人群的证据相反,低成本饮食人群的 EAT-Lancet 得分更高(从 0 到 42 的评分中,20.3 分对 19.4 分;p与高收入国家的证据相反,本研究表明,在墨西哥,坚持 EAT-Lancet 参考饮食与较低的饮食成本有关,特别是在社会经济地位较低的群体中。这些研究结果表明,在不增加经济负担的情况下,有可能更广泛地实施更健康的饮食。
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引用次数: 0
Different levels of physical activity and risk of developing type 2 diabetes among adults with prediabetes: a population-based cohort study. 不同运动量与糖尿病前期成人罹患 2 型糖尿病的风险:一项基于人群的队列研究。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-17 DOI: 10.1186/s12937-024-01013-4
Wenchang Yang, Yuntao Wu, Yue Chen, Shuohua Chen, Xiang Gao, Shouling Wu, Liang Sun

Objectives: This study aimed to evaluate the association between different levels of physical activity and risk of developing type 2 diabetes (T2D) mellitus among adults with prediabetes in Chinese population.

Methods: This prospective population-based cohort study included 12,424 participants (mean [SD] age, 52.8 [16.8] years; 82.2% men) with prediabetes at 2014 survey of the Kailuan study. Physical activity information was collected through the International Physical Activity Questionnaire-Short Form and categorized by metabolic equivalent (MET) of task as low, moderate, and high. Cox regression models were built to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between physical activity levels and incident T2D.

Results: During a median follow-up of 3.6 years, 2,207 (17.8%) participants developed T2D. The incident rate of T2D were 55.83/1000, 35.14/1000, and 39.61/1000 person-years in the low, moderate, and high physical activity level group, respectively. Both moderate (HR 0.57, 95% CI 0.49 to 0.67) and high (HR 0.76, 95% CI 0.66 to 0.89) physical activity levels were associated with lower risks of developing T2D compared to low physical activity level (P for trend < 0.001). The association between high physical activity level and T2D was primarily observed in participants without metabolic syndrome (P for interaction < 0.001). Moreover, participants with moderate or high levels of physical activity had significantly decreased fasting blood glucose levels during follow-up when compared to those with low level (P group*time < 0.001).

Conclusion: This study suggested that individuals with prediabetes might benefit from moderate and high levels of physical activity.

研究目的本研究旨在评估不同体力活动水平与中国成年糖尿病前期患者罹患2型糖尿病(T2D)风险之间的关系:这项前瞻性人群队列研究纳入了开滦研究2014年调查的12424名糖尿病前期患者(平均[标码]年龄为52.8[16.8]岁;82.2%为男性)。体力活动信息通过国际体力活动问卷-简表收集,并按任务的代谢当量(MET)分为低、中、高三类。通过建立考克斯回归模型来估算体力活动水平与T2D发病率之间的危险比(HRs)和95%置信区间(CIs):中位随访 3.6 年期间,2207 名参与者(17.8%)患上了 T2D。低、中、高体力活动水平组的 T2D 发生率分别为 55.83/1000、35.14/1000 和 39.61/1000。与低体力活动水平相比,中等体力活动水平(HR 0.57,95% CI 0.49 至 0.67)和高体力活动水平(HR 0.76,95% CI 0.66 至 0.89)与较低的 T2D 发病风险相关(P 为趋势结论):这项研究表明,糖尿病前期患者可从中度和高度的体育锻炼中获益。
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引用次数: 0
Correction: Evolution of dietary patterns in Flanders: an ecological trend study on best-selling cookbook recipes (2008-2018) and their correlation with household purchases. 更正:佛兰德饮食模式的演变:关于畅销食谱(2008-2018 年)及其与家庭购买相关性的生态趋势研究。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-12 DOI: 10.1186/s12937-024-01008-1
Viktor Lowie Juliaan Proesmans, Christophe Matthys, Iris Vermeir, Maggie Geuens
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引用次数: 0
Olfactory performance and odor liking are negatively associated with food neophobia in children aged between 3 and 9 years. 在 3 至 9 岁的儿童中,嗅觉表现和气味喜好与食物恐新症呈负相关。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-11 DOI: 10.1186/s12937-024-01011-6
Agnieszka Sorokowska, Dominika Chabin, Aleksandra Kamieńska, Sabina Barszcz, Katarzyna Byczyńska, Klaudia Fuławka, Arkadiusz Urbanek, Anna Oleszkiewicz

Background: Child food neophobia, i.e., rejection or avoidance of novel foods at a young age, is a prevalent nutrition problem that affects the quality of children's diet and impedes the development of healthy food preferences. Sensory sensitivity can relate to the degree of food neophobia, but previous studies rarely focused on the olfactory component of this problem in children.

Objective: We aimed to thoroughly examine the relationship between various aspects of olfactory sensitivity and food neophobia in children.

Methods: 246 children aged between three and nine years took part in a food neophobia assessment as well as in a comprehensive, psychophysical olfactory testing.

Results: We found that certain smell perception aspects such as lower odor liking, poorer odor identification ability as well as lower sensitivity to an unknown non-food odor all significantly predicted higher food neophobia in children. Among individual characteristics of either a child or a caregiver, only the child's age significantly and positively predicted food neophobia. The exploratory model looking into the role of family environment factors predicting self-reported food neophobia in children revealed that food neophobia was associated with lower control given to a child in this child's feeding process, as well as with a more frequent use of food as a reward in feeding.

Conclusions: We suggest that suppressed olfactory perception and performance can play a unique role in child nutritional difficulties. The study inspires further considerations of olfaction-engaging interventions to counteract food-neophobia in children.

背景:儿童食物新恐惧症(即在年幼时拒绝或回避新奇食物)是一个普遍存在的营养问题,它影响了儿童的饮食质量,并阻碍了健康饮食偏好的发展。感官敏感性可能与食物新恐惧症的程度有关,但以前的研究很少关注儿童这一问题的嗅觉部分:方法:246 名 3 至 9 岁的儿童参加了食物恐惧症评估以及全面的心理物理嗅觉测试:结果:我们发现,气味感知的某些方面,如较低的气味喜好度、较差的气味识别能力以及对未知非食物气味较低的敏感度,都能显著预测儿童较高的食物新恐惧症。在儿童或照顾者的个人特征中,只有儿童的年龄能显著正向预测食物新恐惧症。家庭环境因素对儿童自我报告的食物新恐惧症的预测作用的探索性模型显示,食物新恐惧症与儿童在喂养过程中被赋予的控制权较低以及在喂养过程中更频繁地使用食物作为奖励有关:结论:我们认为,嗅觉感知和表现受到抑制可能会在儿童营养不良中扮演独特的角色。这项研究启发我们进一步考虑采取嗅觉干预措施来消除儿童的食物恐惧症。
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引用次数: 0
Sex-specific associations between total and regional Fat-to-muscle Mass ratio and cardiometabolic risk: findings from the China National Health Survey. 总质量和区域脂肪肌肉质量比与心脏代谢风险之间的性别特异性关联:中国国民健康调查的结果。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-10 DOI: 10.1186/s12937-024-01007-2
Zhiming Lu, Yaoda Hu, Xingming Chen, Qiong Ou, Yawen Liu, Tan Xu, Ji Tu, Ang Li, Binbin Lin, Qihang Liu, Tianshu Xi, Weihao Wang, Haibo Huang, Da Xu, Zhili Chen, Zichao Wang, Huijing He, Guangliang Shan

Background: The fat-to-muscle mass ratio (FMR), integrating the antagonistic effects of fat and muscle mass, has been suggested as a valuable indicator to assess cardiometabolic health independent of overall adiposity. However, the specific associations of total and regional FMR with cardiometabolic risk are poorly understood. We aimed to examine sex-specific associations of total and regional FMR with single and clustered cardiometabolic risk factors (CRFs).

Methods: 13,505 participants aged 20 years and above were included in the cross-sectional study. Fat mass and muscle mass were assessed using a bioelectrical impedance analysis device. FMR was estimated as fat mass divided by muscle mass in corresponding body parts (whole body, arm, leg, and trunk). Clustered CRFs was defined as the presence of two or more risk factors, including hypertension, elevated blood glucose, dyslipidemia, insulin resistance (IR), and hyperuricemia. IR was assessed by the triglyceride glucose (TyG) index. Multivariable logistic regression models were applied to explore the associations of FMR in the whole body and body parts with single and clustered CRFs.

Results: The odds ratios (ORs) increased significantly for all single and clustered CRFs with the per quartile increase of total and regional FMR in both sexes (P for trend < 0.001), following adjustment for confounders. Among the regional parts, FMRs of the legs presented the strongest associations for clustered CRFs in both men and women, with adjusted OR of 8.54 (95% confidence interval (CI): 7.12-10.24) and 4.92 (95% CI: 4.24-5.71), respectively. Significant interactions (P for interaction < 0.05) were identified between age and FMRs across different body parts, as well as between BMI status and FMRs in different regions for clustered CRFs. Restricted cubic splines revealed significant non-linear relationships between FMRs of different body parts and clustered CRFs in both sexes (P for nonlinear < 0.05).

Conclusions: FMRs in the whole body and different regions were significantly associated with single and clustered CRFs in the general Chinese population. The association between FMR and clustered CRFs was more pronounced in youngers than in the elderly.

背景:脂肪-肌肉质量比(FMR)综合了脂肪和肌肉质量的拮抗作用,被认为是评估心脏代谢健康的一个有价值的指标,而不受总体脂肪含量的影响。然而,人们对总肌肉重量比和区域肌肉重量比与心脏代谢风险之间的具体关系知之甚少。我们的目的是研究总脂肪量和区域脂肪量与单一和聚类心脏代谢风险因素(CRFs)的性别特异性关联。使用生物电阻抗分析装置对脂肪量和肌肉量进行评估。FMR以相应身体部位(全身、手臂、腿部和躯干)的脂肪量除以肌肉量来估算。集群 CRFs 的定义是存在两个或两个以上的风险因素,包括高血压、血糖升高、血脂异常、胰岛素抵抗(IR)和高尿酸血症。胰岛素抵抗通过甘油三酯葡萄糖(TyG)指数进行评估。应用多变量逻辑回归模型探讨了全身和身体部位的 FMR 与单个和集群 CRFs 的关系:结果:所有单一和集群 CRFs 的几率比(ORs)都随着男女总 FMR 和区域 FMR 每四分位数的增加而显著增加(P 为趋势结论):在中国普通人群中,全身和不同区域的FMR与单一和聚集性CRF显著相关。与老年人相比,年轻人的全身和不同区域的全血细胞比容与聚集性 CRF 之间的关系更为明显。
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引用次数: 0
Consumption of different types of meat and the risk of chronic limb-threatening ischemia: the Singapore Chinese Health Study. 食用不同种类的肉类与慢性肢体缺血风险:新加坡华人健康研究。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-07 DOI: 10.1186/s12937-024-00991-9
Ariel Fangting Ying, Mohammad Talaei, Derek John Hausenloy, Woon-Puay Koh

Background: Although red meat consumption has been associated with risk of atherosclerotic coronary artery disease and stroke, no prospective study has examined this with the risk of chronic limb-threatening ischemia (CLTI).

Methods: In a prospective study of 63,257 Chinese in Singapore, who were aged 45-74 years old at recruitment, diet was assessed via a validated semi-quantitative food frequency questionnaire. Incident CLTI cases were ascertained via linkage with nationwide hospital records for lower extremity amputation or angioplasty for peripheral arterial disease. Multivariable Cox models were used to examine associations between quartiles of meat intake and CLTI risk.

Results: After a mean follow-up of 18.8 years, there were 1069 cases of CLTI. Higher intake of red meat intake was associated with increased risk of CLTI in a stepwise manner. Comparing extreme quartiles of red meat intake, the hazard ratio (HR) for the association with CLTI risk was 1.24 [95% confidence interval (CI) = 1.03-1.49; P-trend = 0.02]. In stratified analysis, red meat intake had a stronger association with CLTI risk among those without diabetes [HR (95% CI) comparing extreme quartiles = 1.41 (1.10-1.80); P-trend = 0.03] than among those with diabetes at baseline [HR (95% CI) comparing extreme quartiles = 1.04 (0.79-1.38); P-trend = 0.05] (P-interaction = 0.03). Otherwise, the associations were not different by sex, BMI, smoking status, hypertension, alcohol consumption, or history of cardiovascular diseases. Using a theoretical model in substitution analysis that substituted three servings per week of red meat with poultry or fish/shellfish, the relative risk of CLTI was reduced by 13-14%.

Conclusions: Consumption of red meat was associated with higher CLTI risk in this Asian cohort. Substituting red meat with poultry or fish/shellfish may reduce this risk.

背景:尽管食用红肉与动脉粥样硬化性冠状动脉疾病和中风的风险有关,但还没有前瞻性研究将其与慢性威胁肢体缺血(CLTI)的风险联系起来:方法:在一项前瞻性研究中,对 63,257 名年龄在 45-74 岁之间的新加坡华人进行了招募,并通过有效的半定量食物频率问卷对其饮食进行了评估。通过与全国范围内下肢截肢或外周动脉疾病血管成形术的医院记录相联系,确定了CLTI病例。采用多变量 Cox 模型研究肉类摄入量四分位数与 CLTI 风险之间的关系:平均随访 18.8 年后,共有 1069 例 CLTI 病例。红肉摄入量越高,CLTI 风险越高。比较红肉摄入量的极端四分位数,与 CLTI 风险相关的危险比 (HR) 为 1.24 [95% 置信区间 (CI) = 1.03-1.49;P-趋势 = 0.02]。在分层分析中,与基线糖尿病患者[HR(95% CI)比较极端四分位数 = 1.04 (0.79-1.38);P-趋势 = 0.05]相比,非糖尿病患者中红肉摄入量与 CLTI 风险的关系更密切[HR(95% CI)比较极端四分位数 = 1.41 (1.10-1.80);P-趋势 = 0.03](P-交互作用 = 0.03)。除此之外,不同性别、体重指数、吸烟状况、高血压、饮酒量或心血管疾病史之间的相关性没有差异。使用替代分析中的理论模型,即用家禽或鱼类/贝类替代每周三份的红肉,CLTI 的相对风险降低了 13%-14%:结论:在这一亚洲队列中,食用红肉与较高的 CLTI 风险有关。用家禽或鱼类/贝类代替红肉可降低这种风险。
{"title":"Consumption of different types of meat and the risk of chronic limb-threatening ischemia: the Singapore Chinese Health Study.","authors":"Ariel Fangting Ying, Mohammad Talaei, Derek John Hausenloy, Woon-Puay Koh","doi":"10.1186/s12937-024-00991-9","DOIUrl":"10.1186/s12937-024-00991-9","url":null,"abstract":"<p><strong>Background: </strong>Although red meat consumption has been associated with risk of atherosclerotic coronary artery disease and stroke, no prospective study has examined this with the risk of chronic limb-threatening ischemia (CLTI).</p><p><strong>Methods: </strong>In a prospective study of 63,257 Chinese in Singapore, who were aged 45-74 years old at recruitment, diet was assessed via a validated semi-quantitative food frequency questionnaire. Incident CLTI cases were ascertained via linkage with nationwide hospital records for lower extremity amputation or angioplasty for peripheral arterial disease. Multivariable Cox models were used to examine associations between quartiles of meat intake and CLTI risk.</p><p><strong>Results: </strong>After a mean follow-up of 18.8 years, there were 1069 cases of CLTI. Higher intake of red meat intake was associated with increased risk of CLTI in a stepwise manner. Comparing extreme quartiles of red meat intake, the hazard ratio (HR) for the association with CLTI risk was 1.24 [95% confidence interval (CI) = 1.03-1.49; P-trend = 0.02]. In stratified analysis, red meat intake had a stronger association with CLTI risk among those without diabetes [HR (95% CI) comparing extreme quartiles = 1.41 (1.10-1.80); P-trend = 0.03] than among those with diabetes at baseline [HR (95% CI) comparing extreme quartiles = 1.04 (0.79-1.38); P-trend = 0.05] (P-interaction = 0.03). Otherwise, the associations were not different by sex, BMI, smoking status, hypertension, alcohol consumption, or history of cardiovascular diseases. Using a theoretical model in substitution analysis that substituted three servings per week of red meat with poultry or fish/shellfish, the relative risk of CLTI was reduced by 13-14%.</p><p><strong>Conclusions: </strong>Consumption of red meat was associated with higher CLTI risk in this Asian cohort. Substituting red meat with poultry or fish/shellfish may reduce this risk.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"23 1","pages":"103"},"PeriodicalIF":4.4,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Nutrition Journal
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