Yinan Chen, Xiaolong Qiao, Changqing Liu, Jin Zhang, Tao Sun, Ling Kong, Xinru Zhang, Wencheng Song, Chuandong Cheng, Guohua Ni
In this work, the effects of cold atmospheric-pressure plasma (CAP) on glioblastoma are evaluated comprehensively. After CAP treatment, U251 cell viability, migration, and invasion functions were inhibited, while an appropriate dose of CAP had no inhibitory effect on human brain glial cell line cells. Western blots indicated that expression of caspase-3 was upregulated with ki-67 expression downregulated. Moreover, mitochondrial membrane potential decreased, and energy metabolisms of U251 cells were influenced afterward. TUNEL assays and comet assays suggested the DNA damage of U251 cells after CAP treatment. Furthermore, as one of the DNA damage responses associated pathways, the AKT (AKT8 virus oncogene cellular homolog) signaling pathway was also indicated in the work. The findings raise great promise for clinical applications of CAP in glioblastoma treatments.
本研究全面评估了冷大气压等离子体（CAP）对胶质母细胞瘤的影响。经 CAP 处理后，U251 细胞的活力、迁移和侵袭功能均受到抑制，而适当剂量的 CAP 对人脑神经胶质细胞系细胞无抑制作用。Western 印迹显示，Caspase-3 的表达上调，ki-67 的表达下调。此外，线粒体膜电位降低，U251 细胞的能量代谢受到影响。TUNEL 试验和彗星试验表明，CAP 处理后 U251 细胞的 DNA 受到损伤。此外，作为DNA损伤反应的相关途径之一，AKT（AKT8病毒癌基因细胞同源物）信号通路也在研究中得到了证实。这些发现为 CAP 在胶质母细胞瘤治疗中的临床应用带来了巨大希望。
{"title":"Cold atmospheric-pressure plasma selectively inhibits glioblastoma via DNA damage and AKT dephosphorylation in vitro and in vivo","authors":"Yinan Chen, Xiaolong Qiao, Changqing Liu, Jin Zhang, Tao Sun, Ling Kong, Xinru Zhang, Wencheng Song, Chuandong Cheng, Guohua Ni","doi":"10.1002/ppap.202300210","DOIUrl":"https://doi.org/10.1002/ppap.202300210","url":null,"abstract":"In this work, the effects of cold atmospheric-pressure plasma (CAP) on glioblastoma are evaluated comprehensively. After CAP treatment, U251 cell viability, migration, and invasion functions were inhibited, while an appropriate dose of CAP had no inhibitory effect on human brain glial cell line cells. Western blots indicated that expression of caspase-3 was upregulated with ki-67 expression downregulated. Moreover, mitochondrial membrane potential decreased, and energy metabolisms of U251 cells were influenced afterward. TUNEL assays and comet assays suggested the DNA damage of U251 cells after CAP treatment. Furthermore, as one of the DNA damage responses associated pathways, the AKT (AKT8 virus oncogene cellular homolog) signaling pathway was also indicated in the work. The findings raise great promise for clinical applications of CAP in glioblastoma treatments.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139501419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinchen Jiang, Suikai Wang, Jing Ha, Fucheng Liu, Shoujie He, Qing Li
The microscopic dynamics and formation mechanism of Trichel pulse discharge are investigated. A nonequal current transient effect exists in the Trichel pulse discharge. By reducing the limiting current resistance, the simulated current waveforms of Trichel pulse discharge are qualitatively and quantitatively consistent with those in the experiment. The dominant positive ions vary at different stages, which originate from the evolution of dominant reactions for the generation and consumption of charged particles. The existence of positive and negative charged layers results in the attenuation of the electric field at the rising edge of the Trichel pulse. The formation of the Trichel pulse originates from the changes in spatial charge density, resulting in alterations in the spatial electric field and ionization rate.
{"title":"Microscopic dynamics and mechanism of Trichel pulse discharge","authors":"Xinchen Jiang, Suikai Wang, Jing Ha, Fucheng Liu, Shoujie He, Qing Li","doi":"10.1002/ppap.202300196","DOIUrl":"https://doi.org/10.1002/ppap.202300196","url":null,"abstract":"The microscopic dynamics and formation mechanism of Trichel pulse discharge are investigated. A nonequal current transient effect exists in the Trichel pulse discharge. By reducing the limiting current resistance, the simulated current waveforms of Trichel pulse discharge are qualitatively and quantitatively consistent with those in the experiment. The dominant positive ions vary at different stages, which originate from the evolution of dominant reactions for the generation and consumption of charged particles. The existence of positive and negative charged layers results in the attenuation of the electric field at the rising edge of the Trichel pulse. The formation of the Trichel pulse originates from the changes in spatial charge density, resulting in alterations in the spatial electric field and ionization rate.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139475568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Lavrikova, Nitin Chandra Teja Dadi, Helena Bujdáková, Karol Hensel
Cold plasma finds considerable interest in biodecontamination. A major issue is to elucidate the pathways of plasma–bacteria interaction. The present work aims at studying inactivation mechanisms for planktonic bacteria Escherichia coli and Staphylococcus aureus induced by cold plasma generated by a transient spark discharge. Changes in bacterial viability, metabolic activity, membrane integrity, intracellular reactive oxygen species level, and cell morphology reveal different patterns of cellular damage of the bacteria. Our results emphasize the importance of cell membrane integrity and maintenance of intracellular redox balatnce to resist plasma treatment. The physicochemical properties of the plasma-treated liquid (PTL) are monitored. Acidification and accumulation of various reactive species including •OH, H2O2, ONOOH, and NO3− in PTL play crucial roles in bacterial inactivation.
{"title":"Inactivation pathways of Escherichia coli and Staphylococcus aureusinduced by transient spark discharge in liquids","authors":"Aleksandra Lavrikova, Nitin Chandra Teja Dadi, Helena Bujdáková, Karol Hensel","doi":"10.1002/ppap.202300147","DOIUrl":"https://doi.org/10.1002/ppap.202300147","url":null,"abstract":"Cold plasma finds considerable interest in biodecontamination. A major issue is to elucidate the pathways of plasma–bacteria interaction. The present work aims at studying inactivation mechanisms for planktonic bacteria <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> induced by cold plasma generated by a transient spark discharge. Changes in bacterial viability, metabolic activity, membrane integrity, intracellular reactive oxygen species level, and cell morphology reveal different patterns of cellular damage of the bacteria. Our results emphasize the importance of cell membrane integrity and maintenance of intracellular redox balatnce to resist plasma treatment. The physicochemical properties of the plasma-treated liquid (PTL) are monitored. Acidification and accumulation of various reactive species including •OH, H<sub>2</sub>O<sub>2</sub>, ONOOH, and NO<sub>3</sub><sup>−</sup> in PTL play crucial roles in bacterial inactivation.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139409144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Outside Front Cover: Plasma-activated CO2 and CH4 are expected to kinetically promote heterogeneous catalysis for efficient gas valorization via mostly vibrational excitation. Highlighting the importance of plasma-surface interaction, comparatively analyzing which type of plasma and catalysts is the most promising, by which the superiority of fluidized-bed dielectric barrier discharge reactor is confirmed. The fluidized bed with an enlarged catalyst surface and heat transfer augmentation enables better plasma-catalyst coupling and highly nonthermal properties. Fluidized-bed plasma catalysis reactor, powered by renewable energy, alternatively contributes to the electrification of chemical processes and thus reduces the net CO2 emission.
{"title":"Outside Front Cover: Plasma Process. Polym. 1/2024","authors":"Xiaozhong Chen, Hyun-Ha Kim, Tomohiro Nozaki","doi":"10.1002/ppap.202370027","DOIUrl":"https://doi.org/10.1002/ppap.202370027","url":null,"abstract":"<b>Outside Front Cover</b>: Plasma-activated CO<sub>2</sub> and CH<sub>4</sub> are expected to kinetically promote heterogeneous catalysis for efficient gas valorization via mostly vibrational excitation. Highlighting the importance of plasma-surface interaction, comparatively analyzing which type of plasma and catalysts is the most promising, by which the superiority of fluidized-bed dielectric barrier discharge reactor is confirmed. The fluidized bed with an enlarged catalyst surface and heat transfer augmentation enables better plasma-catalyst coupling and highly nonthermal properties. Fluidized-bed plasma catalysis reactor, powered by renewable energy, alternatively contributes to the electrification of chemical processes and thus reduces the net CO<sub>2</sub> emission.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139376092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, the physicochemical properties of plasma-activated water (PAW) prepared from air, , , and plasma and the trend of the concentration of reactive oxygen and nitrogen species (RONS) with respect to time were investigated and related to the effect of PAW on navel orange mold. The results showed that PAW had a strong lethal effect on navel orange mold and could effectively inhibit the mildewing activity of pathogenic spores. In addition, PAW is effective in reducing weight loss and decay of navel oranges during storage. This study suggests the potential application of PAW to prevent fungal infections during storage of agricultural products.
{"title":"Effect of air, O2, Ar, and N2 plasma-activated water on mildewing activity of moldy pathogen of Gannan navel oranges","authors":"Menghao Tan, Wei Chen, Mengchao Li, Qianqian Luo, Yujun Xiao, Fang Liu, Xingquan Wang, Zhiqiang Gao, Xiaopeng Chang, Teng Gong, Jun Huang, Kostya (Ken) Ostrikov","doi":"10.1002/ppap.202300179","DOIUrl":"https://doi.org/10.1002/ppap.202300179","url":null,"abstract":"In this study, the physicochemical properties of plasma-activated water (PAW) prepared from air, <math altimg=\"urn:x-wiley:16128850:media:ppap202300179:ppap202300179-math-0001\" location=\"graphic/ppap202300179-math-0001.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mi mathvariant=\"normal\">O</mi>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${{rm{O}}}_{2}$</annotation>\u0000</semantics></math>, <math altimg=\"urn:x-wiley:16128850:media:ppap202300179:ppap202300179-math-0002\" location=\"graphic/ppap202300179-math-0002.png\">\u0000<semantics>\u0000<mrow>\u0000<mtext>Ar</mtext>\u0000</mrow>\u0000$text{Ar}$</annotation>\u0000</semantics></math>, and <math altimg=\"urn:x-wiley:16128850:media:ppap202300179:ppap202300179-math-0003\" location=\"graphic/ppap202300179-math-0003.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mi mathvariant=\"normal\">N</mi>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${{rm{N}}}_{2}$</annotation>\u0000</semantics></math> plasma and the trend of the concentration of reactive oxygen and nitrogen species (RONS) with respect to time were investigated and related to the effect of PAW on navel orange mold. The results showed that <math altimg=\"urn:x-wiley:16128850:media:ppap202300179:ppap202300179-math-0004\" location=\"graphic/ppap202300179-math-0004.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mi mathvariant=\"normal\">O</mi>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${{rm{O}}}_{2}$</annotation>\u0000</semantics></math> PAW had a strong lethal effect on navel orange mold and could effectively inhibit the mildewing activity of pathogenic spores. In addition, <math altimg=\"urn:x-wiley:16128850:media:ppap202300179:ppap202300179-math-0005\" location=\"graphic/ppap202300179-math-0005.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mi mathvariant=\"normal\">O</mi>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${{rm{O}}}_{2}$</annotation>\u0000</semantics></math> PAW is effective in reducing weight loss and decay of navel oranges during storage. This study suggests the potential application of PAW to prevent fungal infections during storage of agricultural products.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139376052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Larissa A. Klok, Teresa T. Steffen, Henrique R. Sabedra, Luis C. Fontana, Peter Hammer, Felippe M. Marega, Lidiane C. Costa, Luiz A. Pessan, Daniela Becker
Zinc oxide (ZnO) was surface treated using argon plasma at 5 and 15 min, using maleic anhydride (MA) in solid state as the functionalizing agent. The samples were characterized by X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. The results indicate that ZnO surface modification occurs through two main routes: the decomposition of MA and the plasma-induced formation of C–Zn bonds, with 15 min being the most favorable time span. Poly(lactic acid) (PLA) and ZnO were processed in an internal chamber mixer, which was coupled with a torque rheometer and characterized by the Melt Flow Index. Composites containing treated ZnO present fluidity indices closer to those of pure PLA, indicating the functionalization contribution to control the degradation of the polymer matrix.
{"title":"ZnO surface modification with maleic anhydride using plasma treatment","authors":"Larissa A. Klok, Teresa T. Steffen, Henrique R. Sabedra, Luis C. Fontana, Peter Hammer, Felippe M. Marega, Lidiane C. Costa, Luiz A. Pessan, Daniela Becker","doi":"10.1002/ppap.202300165","DOIUrl":"https://doi.org/10.1002/ppap.202300165","url":null,"abstract":"Zinc oxide (ZnO) was surface treated using argon plasma at 5 and 15 min, using maleic anhydride (MA) in solid state as the functionalizing agent. The samples were characterized by X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. The results indicate that ZnO surface modification occurs through two main routes: the decomposition of MA and the plasma-induced formation of C–Zn bonds, with 15 min being the most favorable time span. Poly(lactic acid) (PLA) and ZnO were processed in an internal chamber mixer, which was coupled with a torque rheometer and characterized by the Melt Flow Index. Composites containing treated ZnO present fluidity indices closer to those of pure PLA, indicating the functionalization contribution to control the degradation of the polymer matrix.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139064970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atmospheric dielectric barrier discharge (DBD) is a promising approach for large-area deposition, whose spatiotemporal evolution determines the deposition rate and film chemistry. To investigate the relationship between the discharge and deposition behavior of tetraethoxysilane/oxygen/argon (TEOS//Ar) DBD, a one-dimensional (1D) fluid model was constructed and experimentally verified. The calculation results reveal that TEOS mainly affects the discharge behavior via Penning ionization, while mainly affects discharge via attachment reaction. Penning ionization reduces the excited Ar and the attachment reaction reduces the number of discharges in half voltage cycles. As a result, merely increasing the concentration of TEOS or may not proportionally increase the deposition rate of relevant reactive species.
大气介质阻挡放电（DBD）是一种很有前景的大面积沉积方法，其时空演变决定了沉积速率和薄膜化学性质。为了研究四乙氧基硅烷/氧/氩（TEOS/O2${text{O}}_{2}$/Ar）DBD 的放电和沉积行为之间的关系，我们构建了一个一维（1D）流体模型，并进行了实验验证。计算结果表明，TEOS 主要通过潘宁电离影响放电行为，而 O2${text{O}}_{2}$ 主要通过附着反应影响放电。潘宁电离减少了激发 Ar，而附着反应则减少了半电压周期内的放电次数。因此，仅仅增加 TEOS 或 O2${text{O}}_{2}$ 的浓度可能无法成比例地提高相关活性物种的沉积速率。
{"title":"Spatiotemporal evolution and its impact on the deposition behavior of atmospheric TEOS/O2/Ar plasma: A numerical study","authors":"Jiaxin Chang, Dong Dai, Cheng Zhang, Tao Shao","doi":"10.1002/ppap.202300172","DOIUrl":"https://doi.org/10.1002/ppap.202300172","url":null,"abstract":"Atmospheric dielectric barrier discharge (DBD) is a promising approach for large-area deposition, whose spatiotemporal evolution determines the deposition rate and film chemistry. To investigate the relationship between the discharge and deposition behavior of tetraethoxysilane/oxygen/argon (TEOS/<math altimg=\"urn:x-wiley:16128850:media:ppap202300172:ppap202300172-math-0001\" location=\"graphic/ppap202300172-math-0001.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mi mathvariant=\"normal\">O</mi>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${text{O}}_{2}$</annotation>\u0000</semantics></math>/Ar) DBD, a one-dimensional (1D) fluid model was constructed and experimentally verified. The calculation results reveal that TEOS mainly affects the discharge behavior via Penning ionization, while <math altimg=\"urn:x-wiley:16128850:media:ppap202300172:ppap202300172-math-0002\" location=\"graphic/ppap202300172-math-0002.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mi mathvariant=\"normal\">O</mi>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${text{O}}_{2}$</annotation>\u0000</semantics></math> mainly affects discharge via attachment reaction. Penning ionization reduces the excited Ar and the attachment reaction reduces the number of discharges in half voltage cycles. As a result, merely increasing the concentration of TEOS or <math altimg=\"urn:x-wiley:16128850:media:ppap202300172:ppap202300172-math-0003\" location=\"graphic/ppap202300172-math-0003.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mi mathvariant=\"normal\">O</mi>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${text{O}}_{2}$</annotation>\u0000</semantics></math> may not proportionally increase the deposition rate of relevant reactive species.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139064420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roxanne Z. Walker, Sophia Gershman, Dorothy E. Doughty, John E. Foster
A nonthermal, pulsed spark discharge is applied to three polymer powders in Ar and Ar– gas mixtures. Hydrogen is introduced to assess plasma‐driven decomposition. Gaseous decomposition products, including methane, acetylene, and ethylene, are observed with Fourier‐transform infrared (FTIR). Surface modifications are observed on the residual polymer via attenuated total internal reflection‐FTIR. Time‐averaged rotational, vibrational, and excitation temperatures are characterized in the discharge. The plasma density is found to be around , with rotational and vibrational temperatures ranging from 1500 to 2200 K and an excitation temperature of 1–2 eV. While spark properties did not change with either gas composition or polymer composition, it was determined that the addition of hydrogen promoted higher concentrations of gaseous phase products (promoting hydrogenolysis).
{"title":"Evidence of plasma‐driven decomposition of common plastics exposed to an atmospheric nonthermal discharge","authors":"Roxanne Z. Walker, Sophia Gershman, Dorothy E. Doughty, John E. Foster","doi":"10.1002/ppap.202300155","DOIUrl":"https://doi.org/10.1002/ppap.202300155","url":null,"abstract":"A nonthermal, pulsed spark discharge is applied to three polymer powders in Ar and Ar– gas mixtures. Hydrogen is introduced to assess plasma‐driven decomposition. Gaseous decomposition products, including methane, acetylene, and ethylene, are observed with Fourier‐transform infrared (FTIR). Surface modifications are observed on the residual polymer via attenuated total internal reflection‐FTIR. Time‐averaged rotational, vibrational, and excitation temperatures are characterized in the discharge. The plasma density is found to be around , with rotational and vibrational temperatures ranging from 1500 to 2200 K and an excitation temperature of 1–2 eV. While spark properties did not change with either gas composition or polymer composition, it was determined that the addition of hydrogen promoted higher concentrations of gaseous phase products (promoting hydrogenolysis).","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138944604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shortening the duration of the viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to controlling viral transmission, alleviating the burden on the healthcare system, and ultimately mitigating the impact of the pandemic. This randomized, single-blind, placebo-controlled clinical trial aimed to investigate the safety and efficacy of gargling with plasma-activated water (PAW) on prolonged viral shedding in patients infected with SARS-CoV-2 Delta and Omicron variants. Sixty-two subjects, aged 18–80 years and infected with SARS-CoV-2, were recruited at two coronavirus disease 2019 (COVID-19)-designated hospitals in Shaanxi from January to March 2022. Primary outcomes included cumulative conversion rates, incidence of adverse reactions, and biosafety parameters. Results suggested that PAW gargling treatment might contribute to reducing the duration of SARS-CoV-2 Delta and Omicron variant infections and alleviating symptoms.
{"title":"Safety and efficacy of plasma-activated water on prolonged viral shedding of COVID-19 patients: A randomized controlled trial","authors":"Xiaoya Guo, Xing Lv, Yunfu Wu, Mingming Wang, Shuo Wu, Li Guo, Zifeng Wang, Zhihong Shi, Rui Huang, Hua Zhang, Xiaona Niu, Mingzhe Rong, Liqiang Song, Dingxin Liu","doi":"10.1002/ppap.202300195","DOIUrl":"https://doi.org/10.1002/ppap.202300195","url":null,"abstract":"Shortening the duration of the viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to controlling viral transmission, alleviating the burden on the healthcare system, and ultimately mitigating the impact of the pandemic. This randomized, single-blind, placebo-controlled clinical trial aimed to investigate the safety and efficacy of gargling with plasma-activated water (PAW) on prolonged viral shedding in patients infected with SARS-CoV-2 Delta and Omicron variants. Sixty-two subjects, aged 18–80 years and infected with SARS-CoV-2, were recruited at two coronavirus disease 2019 (COVID-19)-designated hospitals in Shaanxi from January to March 2022. Primary outcomes included cumulative conversion rates, incidence of adverse reactions, and biosafety parameters. Results suggested that PAW gargling treatment might contribute to reducing the duration of SARS-CoV-2 Delta and Omicron variant infections and alleviating symptoms.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138824507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eloïse Mestre, Inna Orel, Daniel Henze, Laura Chauvet, Sebastian Burhenn, Sébastien Dozias, Fabienne Brulé-Morabito, Judith Golda, Claire Douat
As carbon monoxide has a broad spectrum of biological activities, its production by plasma is a significant advantage in medicine. This paper presents a comparative study of the CO production of two plasma jets: a MHz-jet and a kHz-jet. Both were fed with a helium gas with admixture (0%–1%). CO was produced by dissociation and its maximal concentration was hundreds of parts per million, which is safe for clinical applications. For the same specific energy input, the CO production was more efficient for the kHz-jet than the MHz-jet. Both had antibacterial properties on Escherichia coli, and the addition of improved them for the MHz-jet, while it reduced them for the kHz-jet.
{"title":"Comparison of CO production and Escherichia coli inactivation by a kHz and a MHz plasma jet","authors":"Eloïse Mestre, Inna Orel, Daniel Henze, Laura Chauvet, Sebastian Burhenn, Sébastien Dozias, Fabienne Brulé-Morabito, Judith Golda, Claire Douat","doi":"10.1002/ppap.202300182","DOIUrl":"https://doi.org/10.1002/ppap.202300182","url":null,"abstract":"As carbon monoxide has a broad spectrum of biological activities, its production by plasma is a significant advantage in medicine. This paper presents a comparative study of the CO production of two plasma jets: a MHz-jet and a kHz-jet. Both were fed with a helium gas with <math altimg=\"urn:x-wiley:16128850:media:ppap202300182:ppap202300182-math-0001\" location=\"graphic/ppap202300182-math-0001.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mtext>CO</mtext>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${text{CO}}_{2}$</annotation>\u0000</semantics></math> admixture (0%–1%). CO was produced by <math altimg=\"urn:x-wiley:16128850:media:ppap202300182:ppap202300182-math-0002\" location=\"graphic/ppap202300182-math-0002.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mtext>CO</mtext>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${text{CO}}_{2}$</annotation>\u0000</semantics></math> dissociation and its maximal concentration was hundreds of parts per million, which is safe for clinical applications. For the same specific energy input, the CO production was more efficient for the kHz-jet than the MHz-jet. Both had antibacterial properties on <i>Escherichia coli</i>, and the addition of <math altimg=\"urn:x-wiley:16128850:media:ppap202300182:ppap202300182-math-0003\" location=\"graphic/ppap202300182-math-0003.png\">\u0000<semantics>\u0000<mrow>\u0000<msub>\u0000<mtext>CO</mtext>\u0000<mn>2</mn>\u0000</msub>\u0000</mrow>\u0000${text{CO}}_{2}$</annotation>\u0000</semantics></math> improved them for the MHz-jet, while it reduced them for the kHz-jet.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138824785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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