Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.11
I. A. Bondorina, A. Kabanov, N. Mamaeva, J. Khokhlacheva, G. Savelieva, V. Kudusova
The current policy of forming the collection fund of the laboratory of ornamental plants of the MBG RAS is aimed at creating not only large, but also unique collections that can be in demand in various aspects of research work. Thus one of the most actual and obvious basic directions of use of resources of a collection fund is the organization on its basis of selection work. So, it can be used as a source of formation of working collections for realization of two most often applied principles of selection of pairs for crosses: ecological and geographical and on a complex of economic and biological signs. The aim of the work is to create varieties of ornamental plants based on the use of genetic resources of the collection background of MBG RAS. Representatives of 4 generic complexes from the collection fund of the laboratory of ornamental plants of MBG RAS: Astilbe, Dahlia, Iris and Phlox were used as model objects. The creation of populations for selection is carried out using artificial inter-port and interspecific hybridization, as well as free and limited-free pollination. In the selection of parent pairs and the selection of maternal forms (with free pollination), the concept of the trait is mainly applied. Selection is carried out mainly from populations of F1 hybrids. The method of selection is individual, according to the complex of decorative and economically valuable features. Currently, 6 breeding numbers have been prepared for transfer to the state selection test: 4 representatives of the genus Dahlia and 2 representatives of the genus Astilbe. Keywords—MBG RAS, collection fund, herbaceous perennials, selection process, working collections, prospective breeding numbers
{"title":"Modern Collection Fund of the Laboratory of Ornamental Plants of the Main Botanical Garden of the Russian Academy of Sciences as a Source of Genetic Resources for Breeding","authors":"I. A. Bondorina, A. Kabanov, N. Mamaeva, J. Khokhlacheva, G. Savelieva, V. Kudusova","doi":"10.2991/isils-19.2019.11","DOIUrl":"https://doi.org/10.2991/isils-19.2019.11","url":null,"abstract":"The current policy of forming the collection fund of the laboratory of ornamental plants of the MBG RAS is aimed at creating not only large, but also unique collections that can be in demand in various aspects of research work. Thus one of the most actual and obvious basic directions of use of resources of a collection fund is the organization on its basis of selection work. So, it can be used as a source of formation of working collections for realization of two most often applied principles of selection of pairs for crosses: ecological and geographical and on a complex of economic and biological signs. The aim of the work is to create varieties of ornamental plants based on the use of genetic resources of the collection background of MBG RAS. Representatives of 4 generic complexes from the collection fund of the laboratory of ornamental plants of MBG RAS: Astilbe, Dahlia, Iris and Phlox were used as model objects. The creation of populations for selection is carried out using artificial inter-port and interspecific hybridization, as well as free and limited-free pollination. In the selection of parent pairs and the selection of maternal forms (with free pollination), the concept of the trait is mainly applied. Selection is carried out mainly from populations of F1 hybrids. The method of selection is individual, according to the complex of decorative and economically valuable features. Currently, 6 breeding numbers have been prepared for transfer to the state selection test: 4 representatives of the genus Dahlia and 2 representatives of the genus Astilbe. Keywords—MBG RAS, collection fund, herbaceous perennials, selection process, working collections, prospective breeding numbers","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87534210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.87
E. Zhilyakova, T. Golivets, Z. Tsvetkova, D. Dubonosova
This article provides the rationale for the pharmacological correction of non-alcoholic fatty liver disease. This is due to the fact that non-alcoholic steatohepatosis of the liver is a slowly progressing disease. Most often, non-alcoholic steatohepatosis progresses to non-alcoholic steatohepatitis, less commonly fibrosis. It should also be noted that if you do not intervene during the disease, steatohepatitis can transform into cirrhosis, bypassing the stage of liver fibrosis. At the same time, the prevalence of non-alcoholic fatty liver dis-ease progressively increases with the age of patients. Thus, the maximum prevalence of non-alcoholic steatosis was noted in the age group of 70–80 years, non-alcoholic steatohepatitis in patients 50–59 years old. Thus, pharmacotherapy of nonalcoholic fatty liver disease should be based on the basic principle of geriatric pharmacotherapy: safety if long-term use of drugs is necessary. In this regard, it substantiates the possibility of using the essential amino acid methionine and flavolignan complex of the fruits of milk thistle for the correction of metabolic conditions associated with non-alcohol steatohepatitis. Keywords—non-alcoholic fatty liver disease, non-alcohol steatohepatitis, geriatric pharmacotherapy, methionine, flavolignan complex
{"title":"Search of New Opportunities of Pharmacological Protection at the Early Stages of a Non-Alcoholic Fatty Liver Disease Associated With Obesity and Metabolic Syndrome","authors":"E. Zhilyakova, T. Golivets, Z. Tsvetkova, D. Dubonosova","doi":"10.2991/isils-19.2019.87","DOIUrl":"https://doi.org/10.2991/isils-19.2019.87","url":null,"abstract":"This article provides the rationale for the pharmacological correction of non-alcoholic fatty liver disease. This is due to the fact that non-alcoholic steatohepatosis of the liver is a slowly progressing disease. Most often, non-alcoholic steatohepatosis progresses to non-alcoholic steatohepatitis, less commonly fibrosis. It should also be noted that if you do not intervene during the disease, steatohepatitis can transform into cirrhosis, bypassing the stage of liver fibrosis. At the same time, the prevalence of non-alcoholic fatty liver dis-ease progressively increases with the age of patients. Thus, the maximum prevalence of non-alcoholic steatosis was noted in the age group of 70–80 years, non-alcoholic steatohepatitis in patients 50–59 years old. Thus, pharmacotherapy of nonalcoholic fatty liver disease should be based on the basic principle of geriatric pharmacotherapy: safety if long-term use of drugs is necessary. In this regard, it substantiates the possibility of using the essential amino acid methionine and flavolignan complex of the fruits of milk thistle for the correction of metabolic conditions associated with non-alcohol steatohepatitis. Keywords—non-alcoholic fatty liver disease, non-alcohol steatohepatitis, geriatric pharmacotherapy, methionine, flavolignan complex","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89414184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.68
N. Shvetsov, V. Kotarev, A. Kovrigin, M. Shvetsova
The experiment was carried out according to the following scheme. In the first group (control), all wheat, barley and corn grains were fed in flattened form, in the second, third and fourth groups 50% of the wheat, barley and corn grain mass (half the daily supply) was prepared in various ways. In the second group, they were sprouted, in the third, they were extruded, and in the fourth, they were comprehensively prepared by sprouting and then extruding. The differences in the specified nutrients between the first and second groups were unreliable and were at the level of 0.92.2 relative percent. The extrusion of wheat, barley, and corn grains and their inclusion into the fodder mixture of animals of the third group contributed to an even greater increase in the digestibility of substances in comparison with the first and second groups. The differences amounted to 1.9-3.4% and showed reliable differences in dry matter and nitrogen-free extract substances. In the fourth group of cows fed with a mixture of comprehensively processed grain components, the digestibility of all substances showed a noticeable increase; the difference with control was reliable and amounted to 2.7-5.4 relative percent. Keywords—methods of preparing fodder for feeding, sprouting, extrusion, digestibility of diet nutrients, dairy cows, productivity
{"title":"Effect of Sprouted and Extruded Grain in Composition of Fodder Mixtures on Digestibility of Dairy Cows Diet Nutrients","authors":"N. Shvetsov, V. Kotarev, A. Kovrigin, M. Shvetsova","doi":"10.2991/isils-19.2019.68","DOIUrl":"https://doi.org/10.2991/isils-19.2019.68","url":null,"abstract":"The experiment was carried out according to the following scheme. In the first group (control), all wheat, barley and corn grains were fed in flattened form, in the second, third and fourth groups 50% of the wheat, barley and corn grain mass (half the daily supply) was prepared in various ways. In the second group, they were sprouted, in the third, they were extruded, and in the fourth, they were comprehensively prepared by sprouting and then extruding. The differences in the specified nutrients between the first and second groups were unreliable and were at the level of 0.92.2 relative percent. The extrusion of wheat, barley, and corn grains and their inclusion into the fodder mixture of animals of the third group contributed to an even greater increase in the digestibility of substances in comparison with the first and second groups. The differences amounted to 1.9-3.4% and showed reliable differences in dry matter and nitrogen-free extract substances. In the fourth group of cows fed with a mixture of comprehensively processed grain components, the digestibility of all substances showed a noticeable increase; the difference with control was reliable and amounted to 2.7-5.4 relative percent. Keywords—methods of preparing fodder for feeding, sprouting, extrusion, digestibility of diet nutrients, dairy cows, productivity","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87581957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.64
N. Rodionova, E. Popov, M. Syromyatnikov, E. Artemova, E. Pozhidaeva
The nutraceutical aspect of the design of new food products involves the consistent implementation of the design algorithm for multicomponent biocorrector. The analysis of potential natural sources of biologically active substances allows to prioritize products of deep biotechnological processing of oilseed and low oil raw materials, characterized by unique biotechnological potential. Using the developed software product, nomograms were obtained that make it possible to justify and design the composition of functional compositions based on products of deep processing of low-oil raw materials with a given ratio of target biologically active substances. Evaluation of the biopotential of the developed functional compositions showed the possibility of satisfying the daily needs of the body in a wide range of macro and microelements and vitamins. A clear correlation was established between the energy efficiency of food status and an increase in the degree of oxygenation of hemoglobin in the blood. Keywords—nutrient biocorrections, nutritional factors, essential components, neural network modeling, 3D printing of food systems, hygiene status
{"title":"Alimentary factors for the correction of nutritional status and physiological conditions","authors":"N. Rodionova, E. Popov, M. Syromyatnikov, E. Artemova, E. Pozhidaeva","doi":"10.2991/isils-19.2019.64","DOIUrl":"https://doi.org/10.2991/isils-19.2019.64","url":null,"abstract":"The nutraceutical aspect of the design of new food products involves the consistent implementation of the design algorithm for multicomponent biocorrector. The analysis of potential natural sources of biologically active substances allows to prioritize products of deep biotechnological processing of oilseed and low oil raw materials, characterized by unique biotechnological potential. Using the developed software product, nomograms were obtained that make it possible to justify and design the composition of functional compositions based on products of deep processing of low-oil raw materials with a given ratio of target biologically active substances. Evaluation of the biopotential of the developed functional compositions showed the possibility of satisfying the daily needs of the body in a wide range of macro and microelements and vitamins. A clear correlation was established between the energy efficiency of food status and an increase in the degree of oxygenation of hemoglobin in the blood. Keywords—nutrient biocorrections, nutritional factors, essential components, neural network modeling, 3D printing of food systems, hygiene status","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86261578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.48
E. Martynova, P. Kornienko, S. Kornienko, S. Verbitskaya
The aim of this work was to study the mechanisms of action and determine the effectiveness of the use of probiotic fodder additives «Amilocin» in the production of food eggs. In the course of the experiments, we found that the introduction of «Amilocin» supplement with water to laying hens of the cross Hisex Brown in the amount of 0.4 g; 0.5 g; 0.6 g per head per day for 10 days at the beginning of oviposition, the average weight of one egg increased by 0.86 g, 1.98 g and 0.12 g or 1.6%, 3.7% and 0.2 % respectively, in comparison with the control group that did not receive «Amilocin». Egg production per an average layer over the period of the experiment increased by 0.2; 0.6; 0.2 pieces in comparison with
{"title":"«Amilocin» Probiotic Fodder Additive in Laying Hens' Rations","authors":"E. Martynova, P. Kornienko, S. Kornienko, S. Verbitskaya","doi":"10.2991/isils-19.2019.48","DOIUrl":"https://doi.org/10.2991/isils-19.2019.48","url":null,"abstract":"The aim of this work was to study the mechanisms of action and determine the effectiveness of the use of probiotic fodder additives «Amilocin» in the production of food eggs. In the course of the experiments, we found that the introduction of «Amilocin» supplement with water to laying hens of the cross Hisex Brown in the amount of 0.4 g; 0.5 g; 0.6 g per head per day for 10 days at the beginning of oviposition, the average weight of one egg increased by 0.86 g, 1.98 g and 0.12 g or 1.6%, 3.7% and 0.2 % respectively, in comparison with the control group that did not receive «Amilocin». Egg production per an average layer over the period of the experiment increased by 0.2; 0.6; 0.2 pieces in comparison with","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80532476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.13
N. Boyko, E. Zhilyakova, O. Novikov, D. Pisarev, A. Bondarev, Z. Tsvetkova, E. Timoshenko, Tatjana Pankrusheva
The purpose of this work is an experimental study of the extraction properties of Novec 1230 perfluoro organic solvent in regards to various types of low-polar biologically active substances from plant materials. For the study purposes, we used the following ground plant raw materials with particle size 0.1-0.5 mm: Anethum graveolens L. fruits, Eucalyptus viminalis Labill. leaves, Foeniculum vulgare Mill. fruits, Hypericum perforatum L. herb, Pastinaca sativa L. fruits, Pimpinella anisum L. fruits, Syzygium aromaticum L. buds (Clove buds), and Tumeric powder. For analytical purposes, we used the following standard samples: eugenol, carvone, trans-anethole, xanthotoxin, evcalimin, and spissum extract of Chlorophyllipt of the State Pharmacopoeia of Ukraine. Novec 1230 was used as a perfluoro organic solvent. RP HPLC and GC-MS were used as quantitative and qualitative analytical methods, respectively. For the extraction, we used the circulation method in “Soxhlet” extractor at the following conditions: plant raw material:extractant ratio 1:5 m/v, extraction time 1 and 3 h. It is found that in three hours of extraction with Novec 1230 perfluoro organic solvent, the low molecular weight components of essential oils are as follows: anethole and carvone (yield≥94%); eugenol is poorly extracted from Syzygium aromaticum L. buds (yield<50%); and chlorophylls, fatty oil, and a number of other low-polar biologically active substances are not extracted. The results obtained are comparable with the technologies for low-polar BAS extraction using liquefied gases or supercritical fluids. The extraction properties of Novec 1230 perfluoro organic solvent were studied experimentally for various types of lowpolar biologically active substances from plant materials. It was found that a very limited number of low-polar biologically active substances are extracted into this type of perfluoro organic solvent, these are mainly components of essential oils, while triglycerides, chlorophylls, and a number of other low-polar biologically active substances are not extracted into this solvent. It is shown that the extraction properties of Novec 1230 perfluoro organic solvent are related to the polar part of TPSA parameter in low-polar BAS molecules. The limit value of TPSA was found in a molecule of low-polar BAS (LTPSA≤30 ± 5 Å2), above which BAS are not extracted into Novec 1230 perfluoro organic solvent. Keywords—perfluoro organic solvent Novec 1230, extraction properties, low-polar biologically active substances, limiting value of TPSA, circulation method in “Soxhlet” extractor.
{"title":"Study of Perfluoro Organic Solvent Novec 1230 Extraction Properties in Regards to Low Polar Substances from Plant Raw Materials","authors":"N. Boyko, E. Zhilyakova, O. Novikov, D. Pisarev, A. Bondarev, Z. Tsvetkova, E. Timoshenko, Tatjana Pankrusheva","doi":"10.2991/isils-19.2019.13","DOIUrl":"https://doi.org/10.2991/isils-19.2019.13","url":null,"abstract":"The purpose of this work is an experimental study of the extraction properties of Novec 1230 perfluoro organic solvent in regards to various types of low-polar biologically active substances from plant materials. For the study purposes, we used the following ground plant raw materials with particle size 0.1-0.5 mm: Anethum graveolens L. fruits, Eucalyptus viminalis Labill. leaves, Foeniculum vulgare Mill. fruits, Hypericum perforatum L. herb, Pastinaca sativa L. fruits, Pimpinella anisum L. fruits, Syzygium aromaticum L. buds (Clove buds), and Tumeric powder. For analytical purposes, we used the following standard samples: eugenol, carvone, trans-anethole, xanthotoxin, evcalimin, and spissum extract of Chlorophyllipt of the State Pharmacopoeia of Ukraine. Novec 1230 was used as a perfluoro organic solvent. RP HPLC and GC-MS were used as quantitative and qualitative analytical methods, respectively. For the extraction, we used the circulation method in “Soxhlet” extractor at the following conditions: plant raw material:extractant ratio 1:5 m/v, extraction time 1 and 3 h. It is found that in three hours of extraction with Novec 1230 perfluoro organic solvent, the low molecular weight components of essential oils are as follows: anethole and carvone (yield≥94%); eugenol is poorly extracted from Syzygium aromaticum L. buds (yield<50%); and chlorophylls, fatty oil, and a number of other low-polar biologically active substances are not extracted. The results obtained are comparable with the technologies for low-polar BAS extraction using liquefied gases or supercritical fluids. The extraction properties of Novec 1230 perfluoro organic solvent were studied experimentally for various types of lowpolar biologically active substances from plant materials. It was found that a very limited number of low-polar biologically active substances are extracted into this type of perfluoro organic solvent, these are mainly components of essential oils, while triglycerides, chlorophylls, and a number of other low-polar biologically active substances are not extracted into this solvent. It is shown that the extraction properties of Novec 1230 perfluoro organic solvent are related to the polar part of TPSA parameter in low-polar BAS molecules. The limit value of TPSA was found in a molecule of low-polar BAS (LTPSA≤30 ± 5 Å2), above which BAS are not extracted into Novec 1230 perfluoro organic solvent. Keywords—perfluoro organic solvent Novec 1230, extraction properties, low-polar biologically active substances, limiting value of TPSA, circulation method in “Soxhlet” extractor.","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82017065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.52
Madina Nastueva, Dmitry V. Kompantsev, G. Sagradyan, I. Privalov, A. Airapetova, A. Serov
The purpose of the study is development technology of receiving mineral waters with nanoparticles of selenium and studying of their stability. The studied samples — the concentrated solution of nanoparticles of selenium contens selenium about 1,4 mg/ml, mineral water of the Krasnoarmeysky source. The expediency, reliability and informational content of a method of photon correlation spectroscopy are shown for assessment of changes in system mineral water – nanoparticles on a nanolevel. Results of researches on studying of aggregate stability of nanoparticles of selenium with a hydrodynamic radius – 37,5-38 nanometers by mixing with mineral water of the Red Army source are presented in article. The stability of the mixtures was evaluated by the size of dispersed particles. In particular stability of particles directly after mixing and under the influence of various physical factors – ultrasonic radiation, an exposition by direct sunlight, the lowered temperature and room temperature is studied. After of storage, the parameters of each of the solutions were studied. As a result of the conducted research the conclusion is drawn that the sample has the maximum stability which prepared by simple mixing at the same time at storage him at the lowered temperature of a particle have the smallest diameter and least are exposed to stratification on fraction. Keywords—nanoselenium, mineral water of the Krasnoarmeysky source, method of photon correlation spectroscopy, stability of nanoparticles, aggregate stability
{"title":"Development of Treatment and Prophylactic Means with Selenium Nanoparticles on the Basis of Mineral Water of the Krasnoarmeysk Source for Application in Balneology","authors":"Madina Nastueva, Dmitry V. Kompantsev, G. Sagradyan, I. Privalov, A. Airapetova, A. Serov","doi":"10.2991/isils-19.2019.52","DOIUrl":"https://doi.org/10.2991/isils-19.2019.52","url":null,"abstract":"The purpose of the study is development technology of receiving mineral waters with nanoparticles of selenium and studying of their stability. The studied samples — the concentrated solution of nanoparticles of selenium contens selenium about 1,4 mg/ml, mineral water of the Krasnoarmeysky source. The expediency, reliability and informational content of a method of photon correlation spectroscopy are shown for assessment of changes in system mineral water – nanoparticles on a nanolevel. Results of researches on studying of aggregate stability of nanoparticles of selenium with a hydrodynamic radius – 37,5-38 nanometers by mixing with mineral water of the Red Army source are presented in article. The stability of the mixtures was evaluated by the size of dispersed particles. In particular stability of particles directly after mixing and under the influence of various physical factors – ultrasonic radiation, an exposition by direct sunlight, the lowered temperature and room temperature is studied. After of storage, the parameters of each of the solutions were studied. As a result of the conducted research the conclusion is drawn that the sample has the maximum stability which prepared by simple mixing at the same time at storage him at the lowered temperature of a particle have the smallest diameter and least are exposed to stratification on fraction. Keywords—nanoselenium, mineral water of the Krasnoarmeysky source, method of photon correlation spectroscopy, stability of nanoparticles, aggregate stability","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76041994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.36
A. Kodash, A. V. Basevich, T. Bitkina, E. Smirnova, I. Kaukhova
The role of the PIC/S organization in the pharmaceutical industry was noted, the main aspects and place of inspection activities in the production of medicines were determined, the general classification of incompliances, as well as the main methods and tools for risk assessment were
{"title":"Audit of the Production of Sterile Medicines for Compliance with the Requirements of the Draft EU GMP Annex 1 with Risk Analysis","authors":"A. Kodash, A. V. Basevich, T. Bitkina, E. Smirnova, I. Kaukhova","doi":"10.2991/isils-19.2019.36","DOIUrl":"https://doi.org/10.2991/isils-19.2019.36","url":null,"abstract":"The role of the PIC/S organization in the pharmaceutical industry was noted, the main aspects and place of inspection activities in the production of medicines were determined, the general classification of incompliances, as well as the main methods and tools for risk assessment were","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76871735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.54
V. Nguyên, A. Dudina, V. Deineka, Thi Ngoc Lan Vu, L. Deineka, Maxim Yapryntev
The supramolecular complex formation in aqueous solution between fatty acids (with the content of αeleostearic acid more than 70%) and β-cyclodextrin, βCD, was supported by FT-IR and UV spectroscopies as well as by XRDanalysis. RP HPLC was utilized for investigation of the content of fatty acid in the inclusion complex and their stability. All results showed that the molecules of fatty acids were successfully included in the β-cyclodextrin cavity. The yield of the inclusion complex is up to 30.1% with a fatty acid content of 20.5%. Due to the formation of inclusion complex, the solubility, and stability of conjugated acids significant increase. Keywords—inclusion complexes, β-cyclodextrin, α-eleostearic acid, yield, composition
{"title":"Supramolecular Complexes of β-Cyclodextrin with Conjugated Fatty Acids: Synthesis and Stability","authors":"V. Nguyên, A. Dudina, V. Deineka, Thi Ngoc Lan Vu, L. Deineka, Maxim Yapryntev","doi":"10.2991/isils-19.2019.54","DOIUrl":"https://doi.org/10.2991/isils-19.2019.54","url":null,"abstract":"The supramolecular complex formation in aqueous solution between fatty acids (with the content of αeleostearic acid more than 70%) and β-cyclodextrin, βCD, was supported by FT-IR and UV spectroscopies as well as by XRDanalysis. RP HPLC was utilized for investigation of the content of fatty acid in the inclusion complex and their stability. All results showed that the molecules of fatty acids were successfully included in the β-cyclodextrin cavity. The yield of the inclusion complex is up to 30.1% with a fatty acid content of 20.5%. Due to the formation of inclusion complex, the solubility, and stability of conjugated acids significant increase. Keywords—inclusion complexes, β-cyclodextrin, α-eleostearic acid, yield, composition","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76577039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.83
Lidia-Ioana Virchea, C. Georgescu, M. Mironescu
The aim of this study was to extract the volatile oils from some aromatic plants and to investigate their antimicrobial and antioxidant activities. The volatile oils were isolated from dried parts of plants by hydro distillation using a neo-Clevenger apparatus. The volatile oils of basil (Ocimum basilicum), thyme (Thymus vulgaris), fennel (Foeniculum vulgare), lovage (Levisticum officinale), marjoram (Majorana hortensis) and dill (Anethum graveolens) were tested in three different quantities against Salmonella typhi, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Candida albicans by disk diffusion method. The antioxidant activity of the volatile oils was determined by DPPH free radical scavenging method. The highest percentage yield of extraction was obtained for basil essential oil (1.26%). Thyme essential oil exhibited the best antimicrobial activity. Thyme essential oil showed an inhibition zone diameter of 50 mm when 1.5 μl of essential oil were tested against S. typhi, B. cereus, E. coli and C. albicans. Marjoram essential oil provided antimicrobial activity against all tested microorganisms. The diameter of inhibition zone observed for 1.5 μl of marjoram volatile oil tested against S. typhi was 17 mm. Lovage, fennel and dill essential oils were active against some bacterial and fungal strains. Basil essential oil was the less active. Thyme volatile oil showed the best antioxidant activity (87.28%). It was followed by lovage (34.99%), basil (30.27%) and marjoram (18.30%) essential oils. Fennel volatile oil and dill volatile oil did not possess antioxidant properties. This study shows that essential oils extracted form aromatic plants can inhibit the growth of some pathogens. Some volatile oils also has antioxidant activity. Therefore, volatile oils could be investigated for their use in pharmaceutical and food products. Keywords—volatile oils, extraction, aromatic plants, antimicrobial activity, antioxidant activity
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