I. Batlutskaya, Evgeniy Selliverstov, D. Myagkov, Nikita Lyakhovchenko, V. Senchenkov
The work describes the procedures used to isolate microorganisms and the initial determination of Shewanella sp. from the Vezjolka River, Belgorod Region of Russia. The isolates obtained during isolation are characterized by signs corresponding to those declared by the authors of the recipe for selective nutrient medium for isolation and determination of Shewanella sp, namely, the green color of the colonies, the zones of turbid precipitate around them, arising due to the activity of bacterial lipase, and a black center indicating production hydrogen sulfide. Keywords—Shewanella; Belgorod region; algicidal activity; bioremediation
{"title":"Isolation of Local Shewanella sp. Strain from Vezjolka River at Belgorod District in Belgorod Region, Russia","authors":"I. Batlutskaya, Evgeniy Selliverstov, D. Myagkov, Nikita Lyakhovchenko, V. Senchenkov","doi":"10.2991/isils-19.2019.5","DOIUrl":"https://doi.org/10.2991/isils-19.2019.5","url":null,"abstract":"The work describes the procedures used to isolate microorganisms and the initial determination of Shewanella sp. from the Vezjolka River, Belgorod Region of Russia. The isolates obtained during isolation are characterized by signs corresponding to those declared by the authors of the recipe for selective nutrient medium for isolation and determination of Shewanella sp, namely, the green color of the colonies, the zones of turbid precipitate around them, arising due to the activity of bacterial lipase, and a black center indicating production hydrogen sulfide. Keywords—Shewanella; Belgorod region; algicidal activity; bioremediation","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78862383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.24
A. Egorova, O. Knysh, K. Vikulova, Yulia Rodina, Yu. I. Latypova, V. Melnikova
The significant importance for preventive measures of early disability of patients with diabetes belongs to drug treatment of underlying and concomitant disease, that must be provided by high –value medicines timely and in full volume. In this regard, it is important to find ways to improve the quality of medicinal care for citizens of this category. The results of development studies of researches of scientific-based recommendations concerning improvements of diabetics preferential provision of medicines (using the example of Tyumen region) are presented in the article. Rationalization directions were suggested together with a scientifically based medicines list for diabetics with concomitant diseases', who has the social benefits in Tyumen region. An optimal model of medicines reference pricing was developed for such category citizens. An economic effect and efficiency was calculated for a potential implementation of this model in Tyumen region. A realization of presented range of measures will promote a rise of availability in our days and effective medicines, improvement of life quality and decrease of chronization of diabetics’ underlying and concomitant diseases. Keywords—diabetes, concomitant disease, optimization of provision of medicines, rationalization of medicines range,
{"title":"Rationalization of the range of medicines for the treatment of patients with diabetes (on the example of the Tyumen region)","authors":"A. Egorova, O. Knysh, K. Vikulova, Yulia Rodina, Yu. I. Latypova, V. Melnikova","doi":"10.2991/isils-19.2019.24","DOIUrl":"https://doi.org/10.2991/isils-19.2019.24","url":null,"abstract":"The significant importance for preventive measures of early disability of patients with diabetes belongs to drug treatment of underlying and concomitant disease, that must be provided by high –value medicines timely and in full volume. In this regard, it is important to find ways to improve the quality of medicinal care for citizens of this category. The results of development studies of researches of scientific-based recommendations concerning improvements of diabetics preferential provision of medicines (using the example of Tyumen region) are presented in the article. Rationalization directions were suggested together with a scientifically based medicines list for diabetics with concomitant diseases', who has the social benefits in Tyumen region. An optimal model of medicines reference pricing was developed for such category citizens. An economic effect and efficiency was calculated for a potential implementation of this model in Tyumen region. A realization of presented range of measures will promote a rise of availability in our days and effective medicines, improvement of life quality and decrease of chronization of diabetics’ underlying and concomitant diseases. Keywords—diabetes, concomitant disease, optimization of provision of medicines, rationalization of medicines range,","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79860232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.19
E. Chuyan, M. Ravaeva, I. Cheretaev, Olga Kornilenko, Anastasia Furkovskaya, E. Birukova
scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3(1,2,4Triazolyl) Propane And 11-Hydroxy-1,1Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex reduces its toxicity by 1.4 times in comparison with characteristics of its precursor components. It was found that the test compound exhibits a dose-dependent hypotensive and vasorelaxating effect, sedative, anxiogenic and analgesic effects. Keywords—spacerized complex bis (2-Pyridyl) -3(1,2,4Triazolyl) Propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid, bioscreening, rats
{"title":"Bioscreening of the spacerized complex BIS (2-Pyridyl)-3-(1,2,4-Triazolyl) propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid","authors":"E. Chuyan, M. Ravaeva, I. Cheretaev, Olga Kornilenko, Anastasia Furkovskaya, E. Birukova","doi":"10.2991/isils-19.2019.19","DOIUrl":"https://doi.org/10.2991/isils-19.2019.19","url":null,"abstract":"scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3(1,2,4Triazolyl) Propane And 11-Hydroxy-1,1Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex reduces its toxicity by 1.4 times in comparison with characteristics of its precursor components. It was found that the test compound exhibits a dose-dependent hypotensive and vasorelaxating effect, sedative, anxiogenic and analgesic effects. Keywords—spacerized complex bis (2-Pyridyl) -3(1,2,4Triazolyl) Propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid, bioscreening, rats","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87996774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.90
E. Zhilyakova, Nabel Mohamad, A. Bakri, D. Naplekov, D. Martseva
Aim of this study is validation of quantitative determination methods for Fexofenadine hydrochloride, Cyanocobalamine in separate ophthalmological dosage forms using UV-spectrophotometry instrumentation. Assay tests of the studied ophthalmological dosage forms were carried out using the APIs and reagents of pharmaceutical grade. As APIs, Fexofenadine hydrochloride, Cyanocobalamine were chosen. For dilution of Fexofenadine hydrochloride dosage form, 5% solution of sodium hydroxide and purified water were used. Solution of cyanocobalamine was diluted by purified water. Spectrophotometer SF-104 was used in this study, manufactured in Russia by Akvilon SZ Company. Spectrophotometric cells with optical path length of 10 mm were used for all the measurements. By the obtained experimental data it was established that the proposed assay methods for Fexofenadine hydrochloride and Cyanocobalamine ophthalmological solutions are reliable and valid. The new methods for Fexofenadine hydrochloride and Cyanocobalamine ophthalmological solutions were proposed and successfully validated in from the perspective of specificity, linearity, analytical range, correctness and repeatability. Keywords—Fexofenadine hydrochloride, assay, ophthalmology, UV-spectrophotometry, cyanocobalamine.
{"title":"Validation of Quantitative Determination Methods for Fexofenadine Hydrochloride and Cyanocobalamine in Separate Ophthalmological Dosage Forms Using UV-Spectrophotometry Instrumentation","authors":"E. Zhilyakova, Nabel Mohamad, A. Bakri, D. Naplekov, D. Martseva","doi":"10.2991/isils-19.2019.90","DOIUrl":"https://doi.org/10.2991/isils-19.2019.90","url":null,"abstract":"Aim of this study is validation of quantitative determination methods for Fexofenadine hydrochloride, Cyanocobalamine in separate ophthalmological dosage forms using UV-spectrophotometry instrumentation. Assay tests of the studied ophthalmological dosage forms were carried out using the APIs and reagents of pharmaceutical grade. As APIs, Fexofenadine hydrochloride, Cyanocobalamine were chosen. For dilution of Fexofenadine hydrochloride dosage form, 5% solution of sodium hydroxide and purified water were used. Solution of cyanocobalamine was diluted by purified water. Spectrophotometer SF-104 was used in this study, manufactured in Russia by Akvilon SZ Company. Spectrophotometric cells with optical path length of 10 mm were used for all the measurements. By the obtained experimental data it was established that the proposed assay methods for Fexofenadine hydrochloride and Cyanocobalamine ophthalmological solutions are reliable and valid. The new methods for Fexofenadine hydrochloride and Cyanocobalamine ophthalmological solutions were proposed and successfully validated in from the perspective of specificity, linearity, analytical range, correctness and repeatability. Keywords—Fexofenadine hydrochloride, assay, ophthalmology, UV-spectrophotometry, cyanocobalamine.","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89544690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.25
Ekaterina Enzekrei, O. Schuklina, A. Soloviev, S. Zavgorodniy, O. Ermolenko, Alexandr Polkhovskiy, I. Voronchihina
In this work we bring the results of the new Timiryazevskaya 42 triticale cultivar potential productivity analysis at different amount of nitrogen fertilizer application. Field experiments held in between 2016 and 2018 on podzol soil showed that increase of fertilizer dose led to the increased yield from 14% to 140%. Timiryazevskaya 42 variety is responsive to the high levels of mineral fertilizer. Dose equal to 150 kg of active ingredient (AI) per 1 hectare (ha) applied during sowing forms an average 12,5 tons per hectare yield of grain. Analysis showed that by using two parameters spike realization coefficient (SRC) and spike mass in the bloom, one can predict the yield maximum and the level of plant potential realization in the middle of vegetation period. Wherein, under favorable weather conditions, the dependence of the studied parameters and the obtained biological productivity at different doses of nitrogen fertilizers is much higher. In 2018, Timiryazevskaya 42 showed the greatest dependence (r = 0.82) of yield on SRC. A study of the formation of crop structure elements showed that the highest correlation (average for three years) was found between biological productivity and the amount of grain per spike (r = 0.62), and between biological productivity and productive bushiness (r = 0.89). Keywords— spring triticale, potential productivity, biological productivity, nitrogen fertilizers, spike realization coefficient
{"title":"Potential Productivity Analysis of the Timiryazevskaya 42 New Spring Triticale Cultivar at Nitrogen Fertilizer Application","authors":"Ekaterina Enzekrei, O. Schuklina, A. Soloviev, S. Zavgorodniy, O. Ermolenko, Alexandr Polkhovskiy, I. Voronchihina","doi":"10.2991/isils-19.2019.25","DOIUrl":"https://doi.org/10.2991/isils-19.2019.25","url":null,"abstract":"In this work we bring the results of the new Timiryazevskaya 42 triticale cultivar potential productivity analysis at different amount of nitrogen fertilizer application. Field experiments held in between 2016 and 2018 on podzol soil showed that increase of fertilizer dose led to the increased yield from 14% to 140%. Timiryazevskaya 42 variety is responsive to the high levels of mineral fertilizer. Dose equal to 150 kg of active ingredient (AI) per 1 hectare (ha) applied during sowing forms an average 12,5 tons per hectare yield of grain. Analysis showed that by using two parameters spike realization coefficient (SRC) and spike mass in the bloom, one can predict the yield maximum and the level of plant potential realization in the middle of vegetation period. Wherein, under favorable weather conditions, the dependence of the studied parameters and the obtained biological productivity at different doses of nitrogen fertilizers is much higher. In 2018, Timiryazevskaya 42 showed the greatest dependence (r = 0.82) of yield on SRC. A study of the formation of crop structure elements showed that the highest correlation (average for three years) was found between biological productivity and the amount of grain per spike (r = 0.62), and between biological productivity and productive bushiness (r = 0.89). Keywords— spring triticale, potential productivity, biological productivity, nitrogen fertilizers, spike realization coefficient","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90944757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.88
E. Zhilyakova, O. Novikov, D. Pisarev, L. Zolotareva
The purpose of this study was to develop a method of qualitative and quantitative assessment of biologically active substances of P. fruticosa L. herb. As object of study was used P. fruticosa L. herb. We used the method of high performance liquid chromatography in reversed-phase variant. As a result of chromatography, it was found that the chromatographic system used can effectively separate and identify the polyphenol complex of the herb P. fruticosus L. The chromatogram shows that the polyphenol complex of the herb P. fruticosus L. consists of the glycosides quercetin, kaempferol, rhamnetin, procyanidins, ellagotannins and ellagic acid and chlorogenic acid. Aglycones were found in the hydrolysis products: quercetin, kempferol, ellagic acid, and trace amounts of rhamnetin. Thus, as a result of this study, the composition of the polyphenolic complex of the herb P. fruticosus L. was established, including the glycosides of quercetin, kaempferol, rhamnetin, proacyanidins, ellagic acid and ellagotannins. A method has been developed for the quantitative determination of the sum of aglycones of grass polyphenols of P. fruticosus L., which is based on the principle of extraction with the simultaneous hydrolysis of glycosides of polyphenols to aglycones and their subsequent chromatographic determination by high performance liquid chromatography and quantification using absolute calibration. Keywords—P. fruticosa L. herb, RP HPLC, quercetin glycosides, kaempferol glycosides, rhamnetin glycosides, proacyanidins, elagic acid, ellagotannins
{"title":"Development of Methods For Quantitative Determination of Polyphenols in Grass Pentaphylloides Fruticosa (L.) O. Schwarz.","authors":"E. Zhilyakova, O. Novikov, D. Pisarev, L. Zolotareva","doi":"10.2991/isils-19.2019.88","DOIUrl":"https://doi.org/10.2991/isils-19.2019.88","url":null,"abstract":"The purpose of this study was to develop a method of qualitative and quantitative assessment of biologically active substances of P. fruticosa L. herb. As object of study was used P. fruticosa L. herb. We used the method of high performance liquid chromatography in reversed-phase variant. As a result of chromatography, it was found that the chromatographic system used can effectively separate and identify the polyphenol complex of the herb P. fruticosus L. The chromatogram shows that the polyphenol complex of the herb P. fruticosus L. consists of the glycosides quercetin, kaempferol, rhamnetin, procyanidins, ellagotannins and ellagic acid and chlorogenic acid. Aglycones were found in the hydrolysis products: quercetin, kempferol, ellagic acid, and trace amounts of rhamnetin. Thus, as a result of this study, the composition of the polyphenolic complex of the herb P. fruticosus L. was established, including the glycosides of quercetin, kaempferol, rhamnetin, proacyanidins, ellagic acid and ellagotannins. A method has been developed for the quantitative determination of the sum of aglycones of grass polyphenols of P. fruticosus L., which is based on the principle of extraction with the simultaneous hydrolysis of glycosides of polyphenols to aglycones and their subsequent chromatographic determination by high performance liquid chromatography and quantification using absolute calibration. Keywords—P. fruticosa L. herb, RP HPLC, quercetin glycosides, kaempferol glycosides, rhamnetin glycosides, proacyanidins, elagic acid, ellagotannins","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74929125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.56
I. Okuneva, J. Khokhlacheva
Authentication of Syringa varieties is required in all major collections. The initial information left by the originators does not make it possible to uniquely identify the varietal affiliation of the samples. In most existing descriptions of varieties, even detailed ones, subjective categories are largely used. The most interesting for the study of intraspecific and intragenital variability, molecular genetic studies, introduction and selection work, as well as for practical gardening are varieties belonging to the S. vulgaris and S. × hyacinthiflora. The aim of the study was to identify a set of constant morphological features that allow us to reliably distinguish and identify varieties of S. vulgaris and S. ×hyacinthiflora. On the basis of long-term observations of the collection of lilacs MBG RAS compiled a sample passport varieties of lilacs, which is an expanded detailed unified description. Of the selected features, 44 were the basis for "Methods of testing for distinctiveness, homogeneity and stability SYRINGA L.» No 12-06/32 from 02.08.2010, FSI State Commission of the Russian Federation for testing and protection of breeding achievements (RTG/1086/1).
所有主要系列都需要对丁香品种进行认证。发端者留下的初始信息不能唯一地确定样品的品种归属。在现有的大多数品种描述中，即使是详细的品种描述，也大量使用主观范畴。在种内和种内变异研究、分子遗传研究、引种和选择工作以及实用园艺方面，最有趣的是属S. vulgaris和S. x hyacinthiflora的品种。该研究的目的是确定一组恒定的形态学特征，使我们能够可靠地区分和识别S. vulgaris和S. ×hyacinthiflora的品种。MBG RAS在对紫丁香采集的长期观察的基础上，编制了一份紫丁香样本护照品种，这是一份扩展的详细的统一描述。在选择的特征中，有44个是俄罗斯联邦FSI国家育种成果检测和保护委员会2010年8月2日发布的“显著性、同质性和稳定性测试方法”(SYRINGA L.»No 12-06/32)的基础。
{"title":"Certification of Collections of Syringa L. Varieties and It’s Significance for their Identification","authors":"I. Okuneva, J. Khokhlacheva","doi":"10.2991/isils-19.2019.56","DOIUrl":"https://doi.org/10.2991/isils-19.2019.56","url":null,"abstract":"Authentication of Syringa varieties is required in all major collections. The initial information left by the originators does not make it possible to uniquely identify the varietal affiliation of the samples. In most existing descriptions of varieties, even detailed ones, subjective categories are largely used. The most interesting for the study of intraspecific and intragenital variability, molecular genetic studies, introduction and selection work, as well as for practical gardening are varieties belonging to the S. vulgaris and S. × hyacinthiflora. The aim of the study was to identify a set of constant morphological features that allow us to reliably distinguish and identify varieties of S. vulgaris and S. ×hyacinthiflora. On the basis of long-term observations of the collection of lilacs MBG RAS compiled a sample passport varieties of lilacs, which is an expanded detailed unified description. Of the selected features, 44 were the basis for \"Methods of testing for distinctiveness, homogeneity and stability SYRINGA L.» No 12-06/32 from 02.08.2010, FSI State Commission of the Russian Federation for testing and protection of breeding achievements (RTG/1086/1).","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74946902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.82
A. Vezentsev, V. Bukhanov, A. Lopanov, N. Zuev, U. Krut, G. Shaidorova
This article studies the action and biocompatibility of the developed montmorillonite-containing preparation “Sorbent” on experimental animals with its longterm use. The local irritating effect of the “Sorbent” preparation was evaluated by its effect on the gastric mucosa of animals with experimental ulcerative pathology. The size of the most common particles in the suspension is 5-8 microns. The experiments were carried out on white rats of the Wistar line and non-linear Hartley guinea pigs. To identify the irritating effect, the drug was administered to animals in therapeutic doses of 200 mg/kg and three times the conditionally therapeutic dose 600 mg/kg of body weight. Destructive changes in the stomachs of experimental animals were studied macroscopically. The ulcerogenic effect was evaluated by calculating the Pauls index. Keywords—enterosorbent, montmorillonite, ulcerative pathology, inflammatory process
{"title":"Clarification of the irritating and toxic effects of bentonite-like clays","authors":"A. Vezentsev, V. Bukhanov, A. Lopanov, N. Zuev, U. Krut, G. Shaidorova","doi":"10.2991/isils-19.2019.82","DOIUrl":"https://doi.org/10.2991/isils-19.2019.82","url":null,"abstract":"This article studies the action and biocompatibility of the developed montmorillonite-containing preparation “Sorbent” on experimental animals with its longterm use. The local irritating effect of the “Sorbent” preparation was evaluated by its effect on the gastric mucosa of animals with experimental ulcerative pathology. The size of the most common particles in the suspension is 5-8 microns. The experiments were carried out on white rats of the Wistar line and non-linear Hartley guinea pigs. To identify the irritating effect, the drug was administered to animals in therapeutic doses of 200 mg/kg and three times the conditionally therapeutic dose 600 mg/kg of body weight. Destructive changes in the stomachs of experimental animals were studied macroscopically. The ulcerogenic effect was evaluated by calculating the Pauls index. Keywords—enterosorbent, montmorillonite, ulcerative pathology, inflammatory process","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90420234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.78
A. Spichak, G. Glembotskaya, Galina Varenykh, I. Zhirova
The article presents the results of a marketing research of the Russian pharmaceutical market of drugs for the treatment of weight disorders overweight and underweight. Macrocontours have been developed, the main trends in market formation have been identified. Keywords—weight disorders, malnutrition, underweight, overweight, marketing research of the pharmaceutical market, macro-contour of the market
{"title":"Marketing Analysis of the Pharmaceutical Market of Drugs for Weight Disorder Treatment","authors":"A. Spichak, G. Glembotskaya, Galina Varenykh, I. Zhirova","doi":"10.2991/isils-19.2019.78","DOIUrl":"https://doi.org/10.2991/isils-19.2019.78","url":null,"abstract":"The article presents the results of a marketing research of the Russian pharmaceutical market of drugs for the treatment of weight disorders overweight and underweight. Macrocontours have been developed, the main trends in market formation have been identified. Keywords—weight disorders, malnutrition, underweight, overweight, marketing research of the pharmaceutical market, macro-contour of the market","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"413 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75195482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.74
I. Spichak, Yuliia Murashko, O. Vladimirova
The article presents the results of the research aimed at Medication Administration improving for pregnant woman with acute respiratory viral. During this social research a medical and social portrait of woman with acute respiratory viral was developed, the analysis of satisfaction and preferences in the choice of pharmaceuticals was carried out. The analysis of pharmaceuticals range for the treatment of acute respiratory viral that are registered in Russia was analyzed. The marketing analysis of the Russian pharmaceutical market for the treatment of ARVI, that pregnant women are allowed to take was carried out. Keywords—pharmaceutical care, pregnant women, acute respiratory viral infections, Russian pharmaceutical market, pharmaceuticals
{"title":"Ways of Medication Administration Improving for Treating Pregnant Women with Acute Respiratory Viral Infection","authors":"I. Spichak, Yuliia Murashko, O. Vladimirova","doi":"10.2991/isils-19.2019.74","DOIUrl":"https://doi.org/10.2991/isils-19.2019.74","url":null,"abstract":"The article presents the results of the research aimed at Medication Administration improving for pregnant woman with acute respiratory viral. During this social research a medical and social portrait of woman with acute respiratory viral was developed, the analysis of satisfaction and preferences in the choice of pharmaceuticals was carried out. The analysis of pharmaceuticals range for the treatment of acute respiratory viral that are registered in Russia was analyzed. The marketing analysis of the Russian pharmaceutical market for the treatment of ARVI, that pregnant women are allowed to take was carried out. Keywords—pharmaceutical care, pregnant women, acute respiratory viral infections, Russian pharmaceutical market, pharmaceuticals","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78012456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：